# newdoc id = /home/UiO/epe/2018/trial/events.txt
# newpar
# sent_id = 1
# text = Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	12	12	NUM	CD	NumType=Card	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
12	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2
# text = IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	covalently	covalently	ADV	RB	_	_	_	_	_
15	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	p35	p35	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p40	p40	NUM	CD	NumType=Card	_	_	_	_
19	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3
# text = This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4
# text = Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflammatory autoimmune diseases.
1	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5
# text = Thus, IL-12 appears to be a critical factor in the generation and maintenance of chronic inflammatory conditions.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	12	12	NUM	CD	NumType=Card	_	_	_	_
6	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6
# text = In this study, we investigated the effects of a commonly prescribed anti-inflammatory drug, acetyl salicylic acid (ASA), on IL-12 production and Th1 cell development.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	commonly	commonly	ADV	RB	_	_	_	_	_
12	prescribed	prescri	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
17	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
18	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	12	12	NUM	CD	NumType=Card	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7
# text = ASA was found to inhibit secretion of the IL-12 heterodimer as well as p40 monomer by human monocytic cells.
1	ASA	ASa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	p40	p40	NUM	CD	NumType=Card	_	_	_	_
17	monomer	monomer	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8
# text = This was associated with the down-regulation of IL-12p40 mRNA expression.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	12p40	12p40	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9
# text = Analysis of the regulation of the p40 gene promoter revealed that ASA inhibited NF-kappaB activation and binding to the p40-kappaB site in the p40 promoter, leading to transcriptional repression of the p40 gene.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	p40	p40	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p40	p40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10
# text = Addition of ASA to an in vitro T helper cell differentiation system, at concentrations compatible with plasma levels reached during anti-inflammatory therapy, resulted in reduced development of Th1 cells.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
16	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11
# text = These results suggest that the inhibition of NF-kappaB activation by ASA leads to down-regulation of IL-12 production and inhibition of Th1 cell development.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ASA	ASa	PROPN	NNP	Number=Sing	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	12	12	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12
# text = Document 0030020 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030020	0030020	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 13
# text = NF-kappa B controls expression of inhibitor
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 14
# text = I kappa
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 15
# text = B alpha:
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 16
# text = evidence for an inducible autoregulatory pathway.
1	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 17
# text = The eukaryotic transcription factor nuclear factor-kappa B (NF-kappa B) participates in many parts of the genetic program mediating T lymphocyte activation and growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
19	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	program	program	NOUN	NN	Number=Sing	_	_	_	_
24	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 18
# text = Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 19
# text = I kappa B alpha.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 20
# text = Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-kappa B is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADV	RB	_	_	_	_	_
35	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 21
# text = Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	GW	_	_	_	_	_
8	B	b	X	GW	_	_	_	_	_
9	alpha	alpha	X	GW	_	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kilodalton	kilodalton	NOUN	NN	Number=Sing	_	_	_	_
19	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 22
# text = Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	newly	newly	ADV	RB	_	_	_	_	_
5	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	p65	p65	NUM	CD	NumType=Card	_	_	_	_
12	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
13	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	prolongs	prolong	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
30	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 23
# text = Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	means	means	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 24
# text = Document 0030021 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030021	0030021	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 25
# text = Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	hypochlorous	hypochlorous	ADJ	JJ	Degree=Pos	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 26
# text = Reactive oxygen species (ROS) such as hydrogen peroxide serve as second messengers in the induction of the transcription factor NF-kappaB, and hence in the activation and replication of human immunodeficiency virus type 1 (HIV-1) in human cells.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
3	species	species	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
10	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
11	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	hence	hence	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	type	type	NOUN	NN	Number=Sing	_	_	_	_
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 27
# text = During inflammatory reactions, many oxidative species are produced, one of which is hypochlorous acid (HOCl), which is responsible for the microbicidal effects of activated human polymorphonuclear leukocytes.
1	During	during	ADP	IN	_	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	species	species	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Int	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	hypochlorous	hypochlorous	ADV	RB	_	_	_	_	_
16	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	polymorphonuclear	polymorphonuclear	NOUN	NN	Number=Sing	_	_	_	_
32	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 28
# text = Treatment of a T-lymphocytic cell line with micromolar concentrations of
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
10	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_

# sent_id = 29
# text = HOCl promoted the appearance of transcription factor NF-kappaB (the heterodimer p50/p65) in the nucleus of the cells, even in the absence of de novo protein synthesis.
1	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
2	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	de	de	NOUN	NN	Number=Sing	_	_	_	_
31	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 30
# text = Western blot analysis of the NF-kappaB inhibitory subunits (IkappaB) demonstrated that both IkappaB-alpha proteolysis and p105 processing were induced by the treatment.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p105	p105	NUM	CD	NumType=Card	_	_	_	_
23	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 31
# text = NF-kappaB activation was very effective when cells were subjected to hyperthermia before being treated with HOCl.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	very	very	ADV	RB	_	_	_	_	_
7	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
14	before	before	SCONJ	IN	_	_	_	_	_
15	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 32
# text = Various antioxidants, such as pyrrolidine dithiocarbamate, p-bromophenacyl-bromide and nordihydroguaiaretic acid could strongly reduce NF-kappaB translocation, demonstrating the importance of oxidative species in the transduction mechanism.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	ADJ	JJ	Degree=Pos	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p-bromophenacyl-bromide	p-bromophenacyl-bromide	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nordihydroguaiaretic	nordihydroguaiaretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	strongly	strongly	ADV	RB	_	_	_	_	_
15	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
26	species	species	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 33
# text = Moreover, ACH-2 cells treated with HOCl or H2O2 released tumour necrosis factor-alpha (TNF-alpha) in the supernatants.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ACH	ACH	DET	DT	_	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
12	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 34
# text = The importance of TNF-alpha release in NF-kappaB induction by HOCl or H2O2 was demonstrated by the fact that: (1) the nuclear appearance of NF-kappaB was promoted in untreated cells; and (2) synergism between TNF-alpha and HOCl was detected.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	release	release	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	H2O2	H2O2	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1	1	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	;	;	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	2	2	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
45	between	between	ADP	IN	_	_	_	_	_
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
51	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
52	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 35
# text = Collectively, these results suggest that HOCl should be considered as an oxidative species capable of inducing NF-kappaB in a T-lymphocytic cell line through a transduction mechanism involving ROS, and having a long-distance effect through subsequent TNF-alpha release.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
8	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
14	species	species	NOUN	NNS	Number=Plur	_	_	_	_
15	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
31	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
32	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	distance	distance	NOUN	NN	Number=Sing	_	_	_	_
40	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
43	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
46	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 36
# text = Document 0030022 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030022	0030022	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 37
# text = Human interferon regulatory factor 2 gene.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	interferon	interferon	ADP	IN	_	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 38
# text = Intron-exon organization and functional analysis of 5'-flanking region.
1	Intron-exon	Intron-exon	ADP	IN	_	_	_	_	_
2	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 39
# text = Interferon regulatory factor 2 (IRF-2) is a transcriptional regulatory protein that terminates interferon beta expression initiated by interferon regulatory factor
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	terminates	terminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	interferon	interferon	ADP	IN	_	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 40
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 41
# text = In this study, we isolated the genomic DNA for human IRF-2 gene, determined the intron-exon structure of the human IRF-2 gene, mapped the major transcription initiation site, identified a number of potential regulatory elements in the 5'-flanking region, and localized the IRF-2 gene on human chromosome 4.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
22	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	number	number	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
43	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
44	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
51	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	_
59	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
60	on	on	ADP	IN	_	_	_	_	_
61	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
62	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
63	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 42
# text = The IRF-2 promoter region contains a CpG island, with several GC boxes, a putative NF-kappa B-binding site, and a CAAT box, but no TATA box.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
10	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
15	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
30	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
35	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 43
# text = When the promoter region was linked with a heterologous reporter gene, we found that the promoter region is inducible by both interferons (interferon-alpha and -gamma) and interferon regulatory factor
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	interferon	interferon	ADP	IN	_	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 44
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 45
# text = The region which induced these inductions was identified as being confined to 40 nucleotides 5' to the major transcriptional initiation site by testing a series of clones with truncated promoter of IRF-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	inductions	induction	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
11	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	40	40	NUM	CD	NumType=Card	_	_	_	_
14	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	testing	teste	VERB	VBG	VerbForm=Ger	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	series	series	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 46
# text = This region contains elements which are shared with the transcriptional enhancers of other genes including interferon regulatory factor 1, interferon beta, and interferon-inducible genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	interferon	interferon	ADP	IN	_	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	interferon	interferon	ADP	IN	_	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 47
# text = These data suggest that interferon regulatory factor 1 not only triggers the activation of the interferon signal transduction pathway, but also may play a role in limiting the duration of this response by activating the transcription of IRF-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interferon	interferon	ADP	IN	_	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	SCONJ	IN	_	_	_	_	_
28	limiting	limite	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	SCONJ	IN	_	_	_	_	_
35	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 48
# text = Document 0030023 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030023	0030023	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 49
# text = IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 50
# text = IL-10 markedly reduces nuclear factor (NF)-kappa B/Rel nuclear activity induced in PBMC by stimulation with the anti-CD3 mAb OKT3.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	markedly	markedly	ADV	RB	_	_	_	_	_
5	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
26	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
27	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 51
# text = The inhibition is exerted specifically on the NF-kappa B/Rel activation induced by mAb OKT3, and not that produced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
18	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 52
# text = As judged by supershifting the DNA-protein complexes with Abs recognizing specific components of the NF-kappa B/Rel protein family, the p50/p65 (Rel A) heterodimeric form of NF-kappa B is primarily affected.
1	As	as	SCONJ	IN	_	_	_	_	_
2	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	supershifting	supershift	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Abs	Abs	PROPN	NNPS	Number=Plur	_	_	_	_
12	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	components	component	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
32	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
35	form	form	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	primarily	primarily	ADV	RB	_	_	_	_	_
43	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 53
# text = The maximal effect is observed at the IL-10 concentration of 20 U/ml.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	20	20	NUM	CD	NumType=Card	_	_	_	_
14	U/ml	u/ml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 54
# text = IL-10 inhibitory activity is exerted on T lymphocytes and is mediated by monocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	exerted	exert	VERB	VBN	Tense=Past|Typo=Yes|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 55
# text = Indeed, monocytes pretreated with IL-10 are able so inhibit NF-kappa B nuclear activity in purified T lymphocytes stimulated with OKT3.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	so	so	ADV	RB	_	_	_	_	_
12	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 56
# text = Soluble factors do not appear to be involved in the mechanism of inhibition.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 57
# text = On the other hand, the up-regulation of CD80
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 58
# text = Ag, found on monocytes obtained from PBMC incubated with OKT3, is not detected after addition of IL-10, and the anti-CD28 mAb CLB-CD28/1 restores the NF-kappa B/Rel nuclear activity in IL-10-inhibited lymphocytes.
1	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
9	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	anti-CD28	anti-CD28	PROPN	NNP	Number=Sing	_	_	_	_
26	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
27	CLB	CLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	CD28/1	CD28/1	PROPN	NNP	Number=Sing	_	_	_	_
30	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 59
# text = Therefore, the NF-kappa B/Rel inhibition might be ascribed to a lack of cooperation between accessory cells and T lymphocytes, resulting from down-regulation of a costimulatory molecule, such as CD80, produced by IL-10 on activated monocytes.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	ascribed	ascribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	10	10	NUM	CD	NumType=Card	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 60
# text = Our results demonstrate that IL-10 can inhibit the induction of NF-kappa B/Rel nuclear activity in CD3-stimulated T lymphocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 61
# text = Since inappropriate activation of kappa B-driven genes has a physiopathologic role in a number of diseases, such as HIV infection, our findings support the possibility of using this cytokine to suppress an undesirable activation of these transcription factors.
1	Since	since	ADP	IN	_	_	_	_	_
2	inappropriate	inappropriate	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	physiopathologic	physiopathologic	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	number	number	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
26	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
27	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	undesirable	undesirable	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 62
# text = Document 0030024 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030024	0030024	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 63
# text = TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	synergistically	synergistically	ADV	RB	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
22	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 64
# text = Activating protein-1 (AP-1) binding TPA responsive elements (TRE) are located downstream of the transcription initiation site in the U5 region of the HIV-1 long terminal repeat (LTR).
1	Activating	Activat	VERB	VBG	VerbForm=Ger	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	TPA	Tpa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TRE	Tre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	U5	U5	PROPN	NNP	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
34	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
35	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 65
# text = These downstream sequence elements, termed DSE, can bind both AP-1 and CREB/ATF transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CREB	Creb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	ATF	Atf	PROPN	NNP	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 66
# text = Recently, we demonstrated that the DSE are also cAMP-responsive elements (CRE), since they mediated activation signals elicited by cholera toxin (Ctx), a potent activator of the cAMP-dependent protein kinase A (PKA) signal transduction pathway.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	cAMP	camp	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	since	since	SCONJ	IN	_	_	_	_	_
19	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
20	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
23	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
26	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
33	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	A	A	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
46	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
47	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 67
# text = In the present study, we demonstrate that the HIV-1 DSE can mediate the transcriptional synergy elicited by the combination of Ctx and TNFalpha.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
19	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 68
# text = Ctx combined with TNFalpha or IL-1beta to produce a synergistic increase in p24 antigen production in U1 promonocytic cells.
1	Ctx	Ctx	NOUN	NN	Number=Sing	_	_	_	_
2	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	p24	p24	NUM	CD	NumType=Card	_	_	_	_
16	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U1	U1	NUM	CD	NumType=Card	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 69
# text = Transfection studies of LTR reporter constructs indicated that mutation of the DSE sites abrogated the LTR-mediated synergy induced by Ctx and TNFalpha, whereas the synergy induced by Ctx and IL-1beta was unaffected, suggesting TNFalpha and IL-1beta cooperate differently with the cAMP/PKA activation pathway to induce HIV-1 expression in U1 cells.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DSE	DSE	PROPN	NNP	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	LTR-	ltr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
46	cooperate	cooperate	NOUN	NN	Number=Sing	_	_	_	_
47	differently	differently	ADV	RB	_	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
52	PKA	PKa	NOUN	NN	Number=Sing	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
55	to	to	PART	TO	_	_	_	_	_
56	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
57	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 70
# text = Because the DSE are also TRE sites, we assessed the effect of the agonist combinations on AP-1-dependent transcription.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	TRE	Tre	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
16	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 71
# text = TNFalpha as well as IL-1beta cooperated with Ctx to produce a synergistic activation of AP-1-mediated transcription.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	cooperated	cooperate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 72
# text = These data indicate that the TRE-like cAMP-responsive DSE sites within the 5'-untranslated leader can mediate the transcriptional cooperativity between TNFalpha and the cAMP/PKA pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	's	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
20	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	PKA	PKa	NOUN	NN	Number=Sing	_	_	_	_
33	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 73
# text = Since the DSE and TRE sites cannot bind CREB/ATF homodimers, we propose a mechanism in which the HIV-1 DSE bind heterodimers composed of both AP-1 and CREB/ATF proteins.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
8	not	not	PART	RB	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
13	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
26	bind	bind	ADP	IN	_	_	_	_	_
27	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
28	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 74
# text = Copyright 1997 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1997	1997	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 75
# text = Document 0030025 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030025	0030025	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 76
# text = Signaling events induced by lipopolysaccharide-activated toll-like receptor
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	events	event	NOUN	NNS	Number=Plur	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 77
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 78
# text = Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 79
# text = Here, we investigate further the events triggered by TLR2 in response to LPS.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	events	event	NOUN	NNS	Number=Plur	_	_	_	_
8	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 80
# text = We show that TLR2 associates with the high-affinity LPS binding protein membrane CD14 to serve as an LPS receptor complex, and that LPS treatment enhances the oligomerization of TLR2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
5	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	LPS	Lp	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
28	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 81
# text = Concomitant with receptor oligomerization, the IL-1R-associated kinase (IRAK) is recruited to the TLR2 complex.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	1R-	1R-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 82
# text = Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa fail to recruit IRAK, which is consistent with the inability of these mutants to transmit LPS cellular signaling.
1	Intracellular	Intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
6	lacking	lack	NOUN	NN	Number=Sing	_	_	_	_
7	C-	C-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	141	141	NUM	CD	NumType=Card	_	_	_	_
12	aa	a	DET	DT	Typo=Yes	_	_	_	_
13	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	recruit	recruit	VERB	VB	VerbForm=Inf	_	_	_	_
16	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	transmit	transmit	VERB	VB	VerbForm=Inf	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
31	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 83
# text = Moreover, both deletion mutants could still form complexes with wild-type TLR2 and act in a dominant-negative (DN) fashion to block TLR2-mediated signal transduction.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	still	still	ADV	RB	_	_	_	_	_
8	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
9	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	act	act	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	DN	DN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
28	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
32	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 84
# text = DN constructs of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing kinase, when coexpressed with TLR2, abrogate TLR2-mediated NF-kappaB activation.
1	DN	Dn	ADJ	JJ	Degree=Pos	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	abrogate	abrogate	ADJ	JJ	Degree=Pos	_	_	_	_
31	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 85
# text = These results reveal a conserved signaling pathway for TLR2 and IL-1Rs and suggest a molecular mechanism for the inhibition of TLR2 by DN variants.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1Rs	-1R	PROPN	NNPS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	DN	Dn	ADJ	JJ	Degree=Pos	_	_	_	_
25	variants	variant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 86
# text = Document 0030026 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030026	0030026	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 87
# text = The role of p16 in the E2F-dependent thymidine kinase regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p16	p16	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 88
# text = The role of alterations of the MTS1 tumor suppressor gene on chromosome 9p21, which encodes p16, the inhibitor of cyclin-dependent-kinase-4 and 6, in tumorigenesis is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MTS1	MTS1	PROPN	NNP	Number=Sing	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	9p21	9p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	tumorigenesis	tumorigenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	yet	yet	ADV	RB	_	_	_	_	_
37	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 89
# text = Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F, which subsequently promotes the expression of S phase regulated genes, such as thymidine kinase.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	subsequently	subsequently	ADV	RB	_	_	_	_	_
25	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	S	s	PROPN	NNP	Number=Sing	_	_	_	_
30	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	thymidine	thymidine	PRON	PRP	_	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 90
# text = Although a role of p16 in this regulation has been presumed, there is no proof so far that loss of this tumor suppressor gene really affects E2F-mediated regulations.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p16	p16	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	there	there	PRON	EX	_	_	_	_	_
14	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	proof	proof	ADJ	JJ	Degree=Pos	_	_	_	_
17	so	so	ADV	RB	_	_	_	_	_
18	far	far	ADV	RB	Degree=Pos	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	really	really	ADV	RB	_	_	_	_	_
27	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	regulations	regulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 91
# text = We investigated the regulation of thymidine kinase in phytohemagglutinin-stimulated normal human lymphocytes and in the p16-negative human acute lymphoblastic leukemia cell lines, MOLT-4 and CEM.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	thymidine	thymidine	PRON	PRP	_	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-negative	-negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
22	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 92
# text = Compared to normal lymphocytes, MOLT-4 and CEM cells exhibited an altered cell cycle regulation of thymidine kinase, a much higher intracellular activity of this enzyme, and higher thymidine kinase mRNA expression.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
24	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
33	thymidine	thymidine	PRON	PRP	_	_	_	_	_
34	kinase	kinase	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 93
# text = Transient expression of p16 in normal human lymphocytes caused arrest in G1, but was without effect on the cell growth of MOLT-4 and CEM cells, although all of them express functional retinoblastoma protein.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p16	p16	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	without	without	ADP	IN	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	MOLT	MOLT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	although	although	SCONJ	IN	_	_	_	_	_
31	all	all	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
34	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
35	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
36	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 94
# text = Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase, paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	16	16	NUM	CD	NumType=Card	_	_	_	_
14	reestablished	reestablish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymidine	thymidine	PRON	PRP	_	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	underphosphorylated	underphosphorylated	ADJ	JJ	Degree=Pos	_	_	_	_
29	form	form	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
37	E2	e2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	F	F	PROPN	NNP	Number=Sing	_	_	_	_
39	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 95
# text = We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p16	p16	NUM	CD	NumType=Card	_	_	_	_
7	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
15	via	via	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	F	F	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
24	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 96
# text = Document 0030027 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030027	0030027	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 97
# text = Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	opposing	oppose	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	chronically	chronically	ADV	RB	_	_	_	_	_
23	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 98
# text = A proportion of HIV-infected individuals experience episodes of localized or systemic bacterial infections caused by Gram-negative bacteria.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
7	experience	experience	NOUN	NN	Number=Sing	_	_	_	_
8	episodes	episode	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
15	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	Gram	Gram	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	bacteria	bacterion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 99
# text = Many of the clinical side effects of these infections are associated with the production of proinflammatory cytokines, which are induced primarily by LPS, a constituent of the bacterial cell wall of Gram-negative bacteria.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	side	side	NOUN	NN	Number=Sing	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	primarily	primarily	ADV	RB	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	constituent	constituent	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Gram-	Gram-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
36	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 100
# text = The present study examines the mechanisms involved in LPS-mediated induction of HIV expression in U1 cells, a promonocytic cell line chronically infected with HIV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	examines	examine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 101
# text = Stimulation of U1 cells by LPS alone induced minimal levels of HIV expression, which was significantly enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF).
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U1	U1	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 102
# text = Costimulation of U1 cells with LPS plus GM-CSF resulted in the accumulation of steady-state levels of HIV RNA; however, only a weak induction of HIV long terminal repeat-driven transcription, which was not associated with the activation of the cellular transcription factor nuclear factor-kappa B, was noted.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U1	U1	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	plus	plus	CCONJ	CC	_	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	state	state	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
32	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
33	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
34	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
51	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
55	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
58	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 103
# text = Costimulation of cells with LPS plus GM-CSF induced the production of proinflammatory cytokines, IL-8, IL-1 beta and IL-6, but not TNF-alpha.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	plus	plus	CCONJ	CC	_	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 104
# text = IL-1 receptor antagonist (ra) inhibited LPS enhancement of HIV expression in GM-CSF-stimulated cells, suggesting that endogenous IL-1 was involved in LPS-mediated viral production.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ra	ra	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 105
# text = In this regard, anti-inflammatory cytokines inhibited LPS plus GM-CSF-stimulated HIV expression, and this effect closely correlated with inhibition of IL-1 beta release and, in particular, with up-regulation of endogenous IL-1ra production.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
9	plus	plus	CCONJ	CC	_	_	_	_	_
10	GM-	GM-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	closely	closely	ADV	RB	_	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	release	release	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	ra	ra	NOUN	NN	Number=Sing	_	_	_	_
44	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 106
# text = Thus, the balance between an endogenously produced viral inducer (IL-1 beta ) and an inhibitor (IL-1ra) may represent an important pathway leading to modulation of
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	endogenously	endogenously	ADV	RB	_	_	_	_	_
8	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1ra	1ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_

# sent_id = 107
# text = HIV expression from monocytic cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 108
# text = Document 0030028 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030028	0030028	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 109
# text = Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	SCONJ	IN	_	_	_	_	_
12	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
13	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 110
# text = CD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells.
1	CD40/CD40	CD40/CD40	NUM	CD	NumType=Card	_	_	_	_
2	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
3	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 111
# text = The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	widely	widely	ADV	RB	_	_	_	_	_
16	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	about	about	SCONJ	IN	_	_	_	_	_
27	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
28	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
29	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	tonsillar	tonsillar	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 112
# text = Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	highly	highly	ADV	RB	_	_	_	_	_
10	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 113
# text = After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations.
1	After	after	SCONJ	IN	_	_	_	_	_
2	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
3	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	both	both	DET	DT	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 114
# text = However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	components	component	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
32	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	both	both	DET	DT	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	whereas	whereas	SCONJ	IN	_	_	_	_	_
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	only	only	ADV	RB	_	_	_	_	_
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 115
# text = In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 116
# text = These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 117
# text = This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	hyper	hyper	NOUN	NN	Number=Sing	_	_	_	_
22	IgM	Igm	NOUN	NN	Number=Sing	_	_	_	_
23	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	whom	whom	PRON	WP	PronType=Rel	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 118
# text = B cell activation has been reported.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 119
# text = Document 0030029 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030029	0030029	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 120
# text = Identification of an I kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on I kappa B alpha.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	GW	_	_	_	_	_
6	B	B	X	GW	_	_	_	_	_
7	alpha	alpha	X	GW	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 121
# text = Nuclear factor kappa B (NF-kappa B) is stored in the cytoplasm as an inactive form through interaction with I kappa B. Stimulation of cells leads to a rapid phosphorylation of I kappa B alpha, which is presumed to be important for the subsequent degradation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	stored	store	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	form	form	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
26	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
45	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
49	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 122
# text = We have recently reported the establishment of a lipopolysaccharide (LPS)-dependent cell-free activation system of NF-kappa B in association with the induction of I kappa B alpha phosphorylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	system	system	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	association	association	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADP	IN	_	_	_	_	_
35	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 123
# text = In this study, we have identified a kinase in cell extracts from the LPS-stimulated human monocytic cell line, THP-1, that specifically binds and phosphorylates I kappa B alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	specifically	specifically	ADV	RB	_	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 124
# text = LPS stimulation transiently enhanced the I kappa B alpha-bound kinase activity in THP-1 cells.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	transiently	transiently	ADV	RB	_	_	_	_	_
4	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 125
# text = Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
10	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
14	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
15	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	Ser	Ser	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Thr	Thr	PROPN	NNP	Number=Sing	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
32	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
33	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	B	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 126
# text = Moreover, we show that the peptide, corresponding to the C-terminal acidic domain of I kappa B alpha, blocked the LPS-induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
14	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
39	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
40	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
41	B	b	PROPN	NNP	Number=Sing	_	_	_	_
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
48	system	system	NOUN	NN	Number=Sing	_	_	_	_
49	using	using	VERB	VBG	VerbForm=Ger	_	_	_	_
50	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 127
# text = These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_

# sent_id = 128
# text = I kappa B alpha and subsequent dissociation of the NF-kappa B.I kappa B alpha complex.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
7	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
16	B	b	X	LS	_	_	_	_	_
17	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 129
# text = Document 00300210 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300210	00300210	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 130
# text = Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 131
# text = Epstein-Barr virus (EBV) infects B cells, resulting in the outgrowth of immortalised lymphoblastoid cell lines (LCLs).
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immortalised	immortalise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 132
# text = Here, we demonstrate through the use of intracellular staining that interleukin-1beta (IL-1beta) is expressed in LCLs and investigate the influence of the individual latent proteins on the expression of IL-1beta.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	LCLs	LCLs	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
32	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 133
# text = Using RT-PCR, IL-1beta was shown to be up-regulated in EBV-transformed LCLs as well as in group III Burkitt's lymphoma (BL) cell lines, compared with group I BL cell lines.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	III	iii	PROPN	NNP	Number=Sing	_	_	_	_
28	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	's	's	PART	POS	_	_	_	_	_
30	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	group	group	NOUN	NN	Number=Sing	_	_	_	_
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
41	BL	Bl	AUX	MD	VerbForm=Fin	_	_	_	_
42	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 134
# text = The up-regulation of IL-1beta message could be mediated by the latent membrane protein-1, EBV nuclear proteins 2, 3, 4, and 6 genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	message	message	NOUN	NN	Number=Sing	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	EBV	EBV	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	6	6	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 135
# text = Electrophoretic mobility shift assays (EMSAs) demonstrated that the -300 region of the IL-1beta promoter, which contains a nuclear factor-kappaB (NF-kappaB) binding site, contained a functional RBP binding site.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	300	300	NUM	CD	NumType=Card	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	RBP	Rbp	PROPN	NNP	Number=Sing	_	_	_	_
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 136
# text = Binding of RBP to this site could be inhibited by addition of EBV nuclear proteins 3 and 6, suggesting that these proteins displace RBP from its recognition sequence, removing transcriptional repression and allowing gene transcription to occur.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	displace	displace	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	RBP	Rbp	PROPN	NNP	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	removing	remove	VERB	VBG	VerbForm=Ger	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 137
# text = In group I BL cells, containing low levels of NF-kappaB, only RBP binding was observed in EMSAs, whereas NF-kappaB binding could be demonstrated in EBV-transformed B cell lines containing high levels of activated NF-kappaB.
1	In	in	ADP	IN	_	_	_	_	_
2	group	group	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	BL	Bl	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 138
# text = In addition, the expression of latent membrane protein-1 led to activation of NF-kappaB that was capable of binding the IL-1beta promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	SCONJ	IN	_	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 139
# text = The study demonstrates that EBV can up-regulate IL-1beta expression, possibly by using RBP, NF-kappaB, or both.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	possibly	possibly	ADV	RB	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 140
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press	Press	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 141
# text = Document 00300211 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300211	00300211	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 142
# text = Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28. CD3, CD2, and CD28 are functionally distinct receptors on T lymphocytes.
1	Uncoupling	Uncoupl	VERB	VBG	VerbForm=Ger	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	HS1	Hs1	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
29	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD28.	CD28.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n
32	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	functionally	functionally	ADV	RB	_	_	_	_	_
40	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
41	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 143
# text = Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn. Ligation of CD3 also induces the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function.
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	group	group	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	p85	p85	NUM	CD	NumType=Card	_	_	_	_
27	phosphoinositide	phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Src	Src	ADJ	JJ	Degree=Pos	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
37	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	Fyn	Fyn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_
41	Ligation	Ligation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
44	also	also	ADV	RB	_	_	_	_	_
45	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
48	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
56	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
60	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
61	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
62	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
65	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 144
# text = We have examined changes in HS1 phosphorylation after differential stimulation of CD3, CD2, and CD28 to elucidate its role in T cells and to further delineate the signaling pathways recruited by these receptors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HS1	HS1	NUM	CD	NumType=Card	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	further	further	ADV	RB	_	_	_	_	_
28	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 145
# text = Unlike ligation of CD3, stimulation with anti-CD28 mAb or CHO cells expressing the CD28 ligands CD80 or CD86 did not lead to tyrosine phosphorylation of HS1 in Jurkat T cells.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
16	ligands	ligand	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	CD86	CD86	PROPN	NNP	Number=Sing	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	tyrosine	tyrosine	VERB	VB	VerbForm=Inf	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 146
# text = Additionally, no tyrosine phosphorylation of HS1 was induced by mitogenic pairs of anti-CD2 mAbs capable of activating the transcription factor NFAT (nuclear factor of activated T cells).
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HS1	Hs1	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
15	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
16	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	SCONJ	IN	_	_	_	_	_
18	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 147
# text = Costimulation through CD28 and/or CD2 did not modulate the CD3-dependent phosphorylation of HS1.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	or	or	CCONJ	CC	_	_	_	_	_
7	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 148
# text = In vivo studies indicated that CD3-induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD45, did not require MEK1 kinase activity, and was regulated by protein kinase C activation.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	HSI	HSI	NUM	CD	NumType=Card	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Src	Src	ADJ	JJ	Degree=Pos	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	Lck	Lck	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
24	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
29	MEK1	MEK1	NUM	CD	NumType=Card	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	C	c	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 149
# text = Thus, although CD3, CD28, and CD2 activate many of the same signaling molecules, they differed in their capacity to induce the tyrosine phosphorylation of HSI.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
10	activate	activate	NOUN	NN	Number=Sing	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
19	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HSI	HSI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 150
# text = Furthermore, activation-dependent tyrosine phosphorylation of HS1 was not required for NFAT transcriptional activation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HS1	Hs1	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 151
# text = Document 00300212 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300212	00300212	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 152
# text = Cytokine rescue from glucocorticoid induced apoptosis in T cells is mediated through inhibition of IkappaBalpha.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 153
# text = We previously reported that dexamethasone (DEX), a synthetic glucocorticoid, causes apoptosis in mature
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 154
# text = Th cell lines, and that this induction of cell death is prevented by specific cytokines, namely, by IL-2 in Th1 cells and by IL-4 in Th2 cells.
1	Th	th	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	death	death	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 155
# text = We now show that this differential rescue by specific cytokines in Th cells correlates with the level of IkappaBalpha that is regulated by DEX and cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
7	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Th	th	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	DEX	Dex	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 156
# text = In both cell types the cellular levels of IkappaBalpha mRNA and protein were evaluated by DEX treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	DEX	Dex	PROPN	NNP	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 157
# text = Interestingly, the DEX-mediated IkappaBalpha induction was completely inhibited by IL-2, but not IL-4, in Th1 cells, while the reverse profile was seen in Th2 cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	completely	completely	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
30	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 158
# text = In both cell types, the cytokine that inhibits the induction of IkappaBalpha by DEX, also rescues these cells from DEX-induced apoptosis, although the rescue cytokine is different in Th1 and Th2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	rescues	rescue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	although	although	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
30	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 159
# text = Our results imply that T cells need to maintain a certain level of NF-kappaB transcriptional activity in order to survive; up- or down-regulation of nuclear NF kappaB through modulation of IkappaBalpha expression by cytokines or DEX may lead to cell survival or cell death, respectively.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	need	need	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	order	order	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
47	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
48	or	or	CCONJ	CC	_	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 160
# text = Document 00300213 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300213	00300213	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 161
# text = Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Cdk	Cdk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 162
# text = The functions of basic helix-loop-helix (bHLH) transcription factors in activating differentiation-linked gene expression and in inducing G1 cell cycle arrest are negatively regulated by members of the Id family of HLH proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	G1	G1	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
26	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	negatively	negatively	ADV	RB	_	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Id	id	PROPN	NNP	Number=Sing	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	HLH	Hlh	DET	DT	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 163
# text = These bHLH antagonists are induced during a mitogenic signalling response, and they function by sequestering their bHLH targets in inactive heterodimers that are unable to bind to specific gene regulatory (E box) sequences.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	bHLH	bhlh	ADJ	JJ	Degree=Pos	_	_	_	_
3	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	function	function	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	sequestering	sequester	VERB	VBG	VerbForm=Ger	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
19	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	E	e	NOUN	NN	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 164
# text = Recently, cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2 has been shown to occur during late G1-to-S phase transition of the cell cycle, and this neutralizes the function of Id2 in abrogating E-box-dependent bHLH homo- or heterodimer complex formation in vitro (E.Hara, M.Hall, and G.Peters, EMBO J.16:332-342, 1997).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
4	E-	e-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	Cdk2	cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
9	A-Cdk2	A-Cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
16	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
18	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	Ser5	Ser5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Id2	id2	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
31	G1	g1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	S	s	NOUN	NN	Number=Sing	_	_	_	_
36	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
37	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
45	neutralizes	neutralize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	function	function	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	Id2	Id2	NUM	CD	NumType=Card	_	_	_	_
50	in	in	SCONJ	IN	_	_	_	_	_
51	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
52	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
57	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	,	_	_	_	_	_
59	or	or	CCONJ	CC	_	_	_	_	_
60	heterodimer	heterodimer	ADJ	JJR	Degree=Cmp	_	_	_	_
61	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
62	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	E.Hara	E.Hara	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	M.Hall	M.Hall	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	G.Peters	G.Peters	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	EMBO	EMBO	PROPN	NNP	Number=Sing	_	_	_	_
74	J.16:332-342	J.16:332-342	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	1997	1997	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 165
# text = We now show that an analogous cell-cycle-regulated phosphorylation of Id3 alters the specificity of Id3 for abrogating both E-box-dependent bHLH homo- or heterodimer complex formation in vitro and E-box-dependent reporter gene function in vivo.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cycle-regulated	cycle-regulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
13	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	SCONJ	IN	_	_	_	_	_
19	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
26	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	heterodimer	heterodimer	ADJ	JJR	Degree=Cmp	_	_	_	_
30	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
31	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	function	function	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 166
# text = Furthermore, compared with wild-type Id3, an Id3 Asp5 mutant (mimicking phosphorylation) is unable to promote cell cycle S phase entry in transfected fibroblasts, whereas an Id3 Ala5 mutant (ablating phosphorylation) displays an activity significantly greater than that of wild-type Id3 protein.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
12	Asp5	asp5	NOUN	NN	Number=Sing	_	_	_	_
13	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	mimicking	mimicking	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
24	S	's	PART	POS	_	_	_	_	_
25	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
26	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
34	Ala5	ala5	NOUN	NN	Number=Sing	_	_	_	_
35	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ablating	ablat	VERB	VBG	VerbForm=Ger	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	significantly	significantly	ADV	RB	_	_	_	_	_
44	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	type	type	NOUN	NN	Number=Sing	_	_	_	_
51	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 167
# text = Cdk2-dependent phosphorylation therefore provides a switch during late G1-to-S phase that both nullifies an early G1 cell cycle regulatory function of Id3 and modulates its target bHLH specificity.
1	Cdk2	Cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	_
6	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
11	G1	G1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	S	S	NOUN	NN	Number=Sing	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	both	both	ADV	RB	_	_	_	_	_
19	nullifies	nullify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	target	target	NOUN	NN	Number=Sing	_	_	_	_
33	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
34	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 168
# text = These data also demonstrate that the ability of Id3 to promote cell cycle S phase entry is not simply a function of its ability to modulate bHLH heterodimer-dependent gene expression and establish a biologically important mechanism through which Cdk2 and
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
14	S	's	PART	POS	_	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	simply	simply	ADV	RB	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	bHLH	bHLH	DET	DT	_	_	_	_	_
28	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	biologically	biologically	ADV	RB	_	_	_	_	_
37	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
39	through	through	ADP	IN	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	Cdk2	Cdk2	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_

# sent_id = 169
# text = Id-bHLH functions are integrated in the coordination of cell proliferation and differentiation.
1	Id	id	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 170
# text = Document 00300214 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300214	00300214	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 171
# text = Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thrombin-	thrombin-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 172
# text = BACKGROUND: Activated platelets tether and activate myeloid leukocytes.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	tether	tether	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 173
# text = To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
5	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
12	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	AMI	Ami	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
33	conjugates	conjugate	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 174
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 175
# text = We obtained peripheral venous blood samples in 20 patients with AMI before and daily for 5 days after direct percutaneous transluminal coronary angioplasty (PTCA) and in 20 patients undergoing elective PTCA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	_
12	before	before	ADV	RB	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	daily	daily	ADV	RB	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	days	day	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
20	percutaneous	percutaneous	ADJ	JJ	Degree=Pos	_	_	_	_
21	transluminal	transluminal	ADJ	JJ	Degree=Pos	_	_	_	_
22	coronary	coronary	NOUN	NN	Number=Sing	_	_	_	_
23	angioplasty	angioplasty	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PTCA	PTCA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	20	20	NUM	CD	NumType=Card	_	_	_	_
30	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
31	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
32	elective	elective	ADJ	JJ	Degree=Pos	_	_	_	_
33	PTCA	PTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 176
# text = Throughout the study period, CD41 immunofluorescence of leukocytes (flow cytometry) revealed increased leukocyte-platelet adhesion in patients with AMI compared with control patients (mean +/- SE of fluorescence [channels] before PTCA: 77 +/- 16 versus 35 +/- 9; P = .003).
1	Throughout	throughout	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD41	CD41	NUM	CD	NumType=Card	_	_	_	_
7	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
12	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	mean	mean	X	GW	_	_	_	_	_
30	+/-	+/-	X	GW	_	_	_	_	_
31	SE	se	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	_
37	before	before	ADP	IN	_	_	_	_	_
38	PTCA	PTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	:	:	PUNCT	:	_	_	_	_	_
40	77	77	NUM	CD	NumType=Card	_	_	_	_
41	+/-	+/-	SYM	SYM	_	_	_	_	_
42	16	16	NUM	CD	NumType=Card	_	_	_	_
43	versus	versus	ADP	IN	_	_	_	_	_
44	35	35	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	P	p	NOUN	NN	Number=Sing	_	_	_	_
49	=	=	SYM	SYM	_	_	_	_	_
50	.003	.003	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 177
# text = In vitro, thrombin-stimulated fixed platelets bound to neutrophils and monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	thrombin-	thrombin-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 178
# text = Within 2 hours, this resulted in increased mRNA for interleukin (IL),1 beta, IL-8, and monocyte chemoattractant protein (MCP)-1 in unfractionated leukocytes.
1	Within	within	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,1	,1	NUM	CD	NumType=Card	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	unfractionated	unfractionated	ADJ	JJ	Degree=Pos	_	_	_	_
33	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 179
# text = After 4 hours, IL-1 beta and IL-8 concentration of the cell-free supernatant had increased by 268 +/- 36% and 210 +/- 7%, respectively, and cellular MCP-1 content had increased by 170 +/- 8%.
1	After	after	ADP	IN	_	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
19	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
20	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	268	268	NUM	CD	NumType=Card	_	_	_	_
24	+/-	+/-	SYM	SYM	_	_	_	_	_
25	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	210	210	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	content	content	NOUN	NN	Number=Sing	_	_	_	_
41	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	170	170	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	8%	8%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 180
# text = Addition of activated platelets to adherent monocytes had a similar effect and was associated with nuclear factor-kappa B activation.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 181
# text = Inhibition of binding by anti-P selectin antibodies reduced the effect of activated platelets on cytokine production.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
6	-P	-p	ADJ	JJ	Degree=Pos	_	_	_	_
7	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 182
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 183
# text = In patients with AMI, leukocyte-platelet adhesion is increased.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 184
# text = Binding of activated platelets induces IL-1 beta, IL-8, and MCP-1 in leukocytes.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 185
# text = Our findings suggest that leukocyte-platelet adhesion contributes to the regulation of inflammatory responses in AMI.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 186
# text = Document 00300215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300215	00300215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 187
# text = Paternal expression of WT1 in human fibroblasts and lymphocytes.
1	Paternal	Paternal	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 188
# text = The Wilms' tumor suppressor gene ( WT1 ) was previously identified as being imprinted, with frequent maternal expression in human placentae and fetal brains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Wilms	Wilm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	'	's	PART	POS	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	_
8	WT1	wt1	PROPN	NNP	Number=Sing	_	_	_	_
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
15	imprinted	imprinted	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	maternal	maternal	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	placentae	placenta	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
26	brains	brain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 189
# text = We examined the allele-specific expression of WT1 in cultured human fibroblasts from 15 individuals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	WT1	WT1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	15	15	NUM	CD	NumType=Card	_	_	_	_
16	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 190
# text = Seven of 15 fibroblast lines were heterozygous for polymorphic alleles, and the expression patterns were variable, i.e., equal, unequal or monoallelic paternal expression in three, two and two cases, respectively.
1	Seven	Seven	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	15	15	NUM	CD	NumType=Card	_	_	_	_
4	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
10	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	unequal	unequal	ADJ	JJ	Degree=Pos	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
26	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	two	two	NUM	CD	NumType=Card	_	_	_	_
34	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 191
# text = Exclusive paternal expression of WT1 was also shown in non-cultured peripheral lymphocytes from the latter two individuals.
1	Exclusive	Exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
2	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	non-cultured	non-cultured	ADJ	JJ	Degree=Pos	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 192
# text = The allele-specific expression profiles of other imprinted genes, IGF2 and H19, on human chromosome 11 were constant and consistent with those in other tissues.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	imprinted	imprint	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IGF2	Igf2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	H19	h19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
19	11	11	NUM	CD	NumType=Card	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 193
# text = Our unexpected observations of paternal or biallelic expression of WT1 in fibroblasts and lymphocytes, together with the previous findings of maternal or biallelic expression in placentae and brains, suggest that the allele-specific regulatory system of WT1 is unique and may be controlled by a putative tissue- and individual-specific modifier.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	unexpected	unexpected	ADJ	JJ	Degree=Pos	_	_	_	_
3	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	together	together	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
20	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	maternal	maternal	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	placentae	placenta	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	brains	brains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	system	system	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
45	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
46	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
50	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
56	modifier	modifier	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 194
# text = Document 00300216 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300216	00300216	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 195
# text = Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.
1	Overproduction	Overproduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	lyt	lyt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-activation	-activation	NOUN	NN	Number=Sing	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
32	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 196
# text = Molecular, biochemical and epidemiological evidence implicate HTLV-I as an etiologic agent of adult T cell leukemia (ATL).
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	epidemiological	epidemiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
8	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
14	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 197
# text = The Tax protein of HTLV-I, a positive transcriptional activator of HTLV-I gene expression, is a viral oncogene that also increases transcription of cellular genes including GM-CSF, IL-2R alpha and IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
39	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 198
# text = One of the cellular targets of the trans-activating effects of Tax is the NF-kappa B/Rel family of transcription factors, pleiotropic regulators of immunoregulatory, cytokine and viral gene expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 199
# text = In this report, we demonstrate that NFKB2 (lyt-10) and c-Rel are overexpressed in HTLV-I infected and Tax-expressing cells and, together, account for the majority of the constitutive NF-kappa B binding activity in these cells before and after PMA stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	lyt	lyt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	infected	infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	account	account	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	before	before	ADP	IN	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	after	after	ADP	IN	_	_	_	_	_
53	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 200
# text = Most importantly, we show a Tax-dependent correlation between expression of NFKB2(p100) and processing to the DNA binding NFKB2(p52) form, induction of c-Rel, and trans-activation of NF-kappa B-mediated gene expression.
1	Most	most	ADV	RBS	_	_	_	_	_
2	importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	processing	process	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 201
# text = Furthermore, the NFKB2 precursor is physically associated with c-Rel and with Tax in HTLV-I infected cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	physically	physically	ADV	RB	_	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 202
# text = We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel, NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NFKB2	Nfkb2	NUM	CD	NumType=Card	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
8	allows	allow	NOUN	NNS	Number=Plur	_	_	_	_
9	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	otherwise	otherwise	ADV	RB	_	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	_
29	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
41	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 203
# text = Document 00300217 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300217	00300217	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 204
# text = Abnormal regulation of the IL-2 promoter in lpr CD4-CD8- T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lpr	lpr	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD4-CD8	CD4-CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 205
# text = The inert quality of MRL-Ipr/Ipr (Ipr) peripheral CD4-CD8- (CD4-8-) T cells manifests primarily as an inability to proliferate or produce IL-2 in response to TCR or mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inert	inert	ADJ	JJ	Degree=Pos	_	_	_	_
3	quality	quality	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	MRL	MRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	CD4-CD8	Cd4-cd8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8-)	8-)	SYM	NFP	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	manifests	manifest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	primarily	primarily	ADV	RB	_	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
40	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 206
# text = Yet these same cells do initiate early TCR-mediated signaling events, such as generation of inositol phosphates and increased intracellular calcium.
1	Yet	yet	CCONJ	CC	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
7	early	early	ADV	RB	Degree=Pos	_	_	_	_
8	TCR	TCR	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	inositol	inositol	ADJ	JJ	Degree=Pos	_	_	_	_
19	phosphates	phosphate	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 207
# text = They also display constitutively high levels of p59fyn and CD3 zeta tyrosine phosphorylation.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p5	p5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	9fyn	9fyn	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 208
# text = The generation of second messengers in T cells normally leads to downstream signaling that results in transcriptional activation of the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	normally	normally	ADV	RB	_	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	downstream	downstream	VERB	VB	VerbForm=Inf	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 209
# text = We, therefore, compared the activation state of the IL-2 gene promoter region in freshly isolated and stimulated Ipr CD4-8- T cells with that of normal T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	state	state	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	freshly	freshly	ADV	RB	_	_	_	_	_
19	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 210
# text = Levels of the octamer, NF-kappa B (p50-p65 heterodimer), and AP-1 transcriptional factors are constitutively elevated in freshly isolated Ipr CD4-8- T cells, consistent with the activated phenotype of these cells.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	B	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	freshly	freshly	ADV	RB	_	_	_	_	_
28	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
30	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	T	t	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 211
# text = Upon stimulation with mitogens, formation of the transactivating complex, nuclear factor of activated T cells (NF-AT), occurs with normal kinetics in Ipr CD4-8- T cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
30	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	T	t	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 212
# text = Yet, the levels of the activating NF-AT complex never reach those observed in similarly stimulated normal T cells.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	never	never	ADV	RB	_	_	_	_	_
13	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADV	RB	_	_	_	_	_
17	similarly	similarly	ADV	RB	_	_	_	_	_
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 213
# text = Furthermore, nuclear extracts from Ipr CD4-8- T cells display high levels of a novel specific binding activity at the NF-AT site, which is present at much lower levels in freshly isolated normal T lymphocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	much	much	ADV	RB	_	_	_	_	_
33	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	freshly	freshly	ADV	RB	_	_	_	_	_
37	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
39	T	t	NOUN	NN	Number=Sing	_	_	_	_
40	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 214
# text = Upon mitogenic stimulation, the binding activity of the novel NF-AT-binding factor is rapidly down-regulated in normal T cells, but persists at high levels in Ipr CD4-8- T cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	novel	novel	PROPN	NNP	Number=Sing	_	_	_	_
11	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	At	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	rapidly	rapidly	ADV	RB	_	_	_	_	_
19	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	persists	persist	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
34	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	_
37	T	t	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 215
# text = These two abnormalities at the NF-AT site provide a potential mechanism to account for the defect in IL-2 production from Ipr CD4-8- T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
26	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 216
# text = Document 00300218 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300218	00300218	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 217
# text = Impaired fetal thymocyte development after efficient adenovirus-mediated inhibition of NF-kappa B activation.
1	Impaired	Impaire	ADJ	JJ	Degree=Pos	_	_	_	_
2	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
3	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 218
# text = We introduce a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	introduce	introduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
6	system	system	NOUN	NN	Number=Sing	_	_	_	_
7	combining	combi	VERB	VBG	VerbForm=Ger	_	_	_	_
8	adenovirus	adenovirus	ADP	IN	_	_	_	_	SpaceAfter=No
9	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
15	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 219
# text = This system allowed us to efficiently express in developing thymocytes a mutant form of the NF-kappa B inhibitor
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	system	system	NOUN	NN	Number=Sing	_	_	_	_
3	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	efficiently	efficiently	ADV	RB	_	_	_	_	_
7	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
13	form	form	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 220
# text = I kappa B alpha (mut-I kappa B) and to study the maturation defects occurring when NF-kappa B activation is inhibited during fetal development.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
17	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
18	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	NF	NF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 221
# text = Fetal thymocytes infected with adenovirus containing mut-I kappa B were found to develop normally until the CD44-CD25+, CD4-CD8- double-negative stage, while production of more mature double-positive and single-positive populations was strongly decreased.
1	Fetal	Fetal	ADJ	JJ	Degree=Pos	_	_	_	_
2	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
6	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
16	normally	normally	ADV	RB	_	_	_	_	_
17	until	until	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD44-CD25+	Cd44-cd25+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	CD4-CD8	Cd4-cd8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	_
23	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
26	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
33	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
40	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	strongly	strongly	ADV	RB	_	_	_	_	_
43	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 222
# text = Proliferation, as measured by the percentage of cells in cycle appeared normal, as did rearrangement and expression of the TCR beta-chain.
1	Proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 223
# text = However, apoptosis was much higher in FTOC infected with adenovirus containing mut-I kappa B than in FTOC infected with a control virus.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	much	much	ADV	RB	_	_	_	_	_
6	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	FTOC	FTOC	PROPN	NNP	Number=Sing	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
12	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	FTOC	FTOC	PROPN	NNP	Number=Sing	_	_	_	_
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	control	control	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 224
# text = Taken together, these results suggest that NF-kappa B plays a crucial role in ensuring the differentiation and survival of thymocytes in the early stages of their development.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	ensuring	ensure	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 225
# text = Document 00300219 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300219	00300219	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 226
# text = An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
37	family	family	NOUN	NN	Number=Sing	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 227
# text = Expression of the human interleukin-2 (IL-2) receptor alpha chain gene is potently upregulated by its own ligand, IL-2.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	potently	potently	ADV	RB	_	_	_	_	_
19	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 228
# text = In this study, we characterize an essential upstream IL-2 response element that contains both consensus and non-consensus GAS motifs, two putative Ets binding sites (EBS), one of which overlaps the consensus GAS motif, and a GATA motif, which overlaps the non-consensus GAS motif.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	characterize	characterize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	non-consensus	non-consensus	ADJ	JJ	Degree=Pos	_	_	_	_
21	GAS	gas	NOUN	NNS	Number=Plur	_	_	_	_
22	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
26	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
39	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
40	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
45	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	which	which	PRON	WDT	PronType=Rel	_	_	_	_
48	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	non-consensus	non-consensus	ADJ	JJ	Degree=Pos	_	_	_	_
51	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
52	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 229
# text = We demonstrate that although the individual components of this element do not respond to IL-2, together they form a composite element capable of conferring IL-2 responsiveness to a heterologous promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	together	together	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	composite	composite	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 230
# text = Multiple factors including Stat5, Elf-1, HMG-I(Y) and GATA family proteins bind to the IL-2 response element and mutation of any one of these binding sites diminishes the activity of this element.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
4	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	any	any	DET	DT	_	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	diminishes	diminish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 231
# text = An unidentified Ets family protein binds to the EBS overlapping the consensus GAS motif and appears to negatively regulate the human IL-2R alpha promoter.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
3	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	EBS	Eb	PROPN	NNP	Number=Sing	_	_	_	_
10	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	negatively	negatively	ADV	RB	_	_	_	_	_
19	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	R	r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 232
# text = Thus, IL-2-induced IL-2R alpha promoter activity requires a complex upstream element, which appears to contain binding sites for both positive and negative regulatory factors.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
17	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 233
# text = Document 00300220 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300220	00300220	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 234
# text = Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
1	Genomic	Genomic	ADJ	JJ	Degree=Pos	_	_	_	_
2	organization	organization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	eotaxin	eotaxin	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 235
# text = Eotaxin is an eosinophil specific beta-chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
1	Eotaxin	Eotaxin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	eosinophil	eosinophil	ADJ	JJ	Degree=Pos	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
9	assumed	assume	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
20	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
23	rhinitis	rhinitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	parasitic	parasitic	ADJ	JJ	Degree=Pos	_	_	_	_
28	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 236
# text = Its expression is stimulus- and cell-specific.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 237
# text = We here describe the genomic organisation (3 exons of 132, 112 and 542 bp and 2 introns of 1211 and 378 bp) and sequence including 3 kb of DNA from the immediate 5' upstream region of the human eotaxin gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	here	here	ADV	RB	PronType=Dem	_	_	_	_
3	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	organisation	organisation	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	132	132	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	112	112	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	542	542	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	introns	intron	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	1211	1211	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	378	378	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	3	3	NUM	CD	NumType=Card	_	_	_	_
30	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	'	'	PUNCT	``	_	_	_	_	_
38	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	eotaxin	eotaxin	NOUN	NN	Number=Sing	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 238
# text = Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.
1	Among	among	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	potentially	potentially	ADV	RB	_	_	_	_	_
7	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	eotaxin	eotaxin	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	or	or	CCONJ	CC	_	_	_	_	_
14	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	like	like	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
44	like	like	ADP	IN	_	_	_	_	_
45	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
46	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	_
52	as	as	ADV	RB	_	_	_	_	_
53	well	well	ADV	RB	Degree=Pos	_	_	_	_
54	as	as	ADP	IN	_	_	_	_	_
55	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
56	response	response	NOUN	NN	Number=Sing	_	_	_	_
57	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 239
# text = Document 00300221 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300221	00300221	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 240
# text = Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.
1	Calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	negatively	negatively	ADV	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	p21Ha	p21Ha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 241
# text = The induction of immediate-early (IE) response genes, such as egr-1, c-fos, and c-jun, occurs rapidly after the activation of T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IE	ie	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	egr	egr	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	occurs	occurs	NOUN	NNS	Number=Plur	_	_	_	_
26	rapidly	rapidly	ADV	RB	_	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 242
# text = The process of activation involves calcium mobilization, activation of protein kinase C (PKC), and phosphorylation of tyrosine kinases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
6	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
7	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 243
# text = p21(ras), a guanine nucleotide binding factor, mediates T-cell signal transduction through PKC-dependent and PKC-independent pathways.
1	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
8	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
13	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	PKC	Pkc	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 244
# text = The involvement of p21(ras) in the regulation of calcium-dependent signals has been suggested through analysis of its role in the activation of NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p21	p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 245
# text = We have investigated the inductions of the IE genes in response to calcium signals in Jurkat cells (in the presence of activated p21(ras)) and their correlated consequences.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inductions	induction	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	calcium	calcium	VERB	VB	VerbForm=Inf	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
32	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 246
# text = The expression of activated p21(ras) negatively regulated the induction of IE genes by calcium ionophore.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	negatively	negatively	ADV	RB	_	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
18	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 247
# text = This inhibition of calcium-activated IE gene induction was reversed by treatment with cyclosporin A, suggesting the involvement of calcineurin in this regulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	calcium-	calcium-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 248
# text = A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	later	later	ADJ	JJ	Degree=Pos	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	ras	ras	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
31	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
32	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 249
# text = These results suggest that p2l(ras) is an essential mediator in generating not only positive but also negative modulatory mechanisms controlling the competence of T cells in response to inductive stimulations.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p2l(	p2l(	SYM	NFP	_	_	_	_	SpaceAfter=No
6	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	generating	generate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	modulatory	modulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
22	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	competence	competence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	inductive	inductive	ADJ	JJ	Degree=Pos	_	_	_	_
32	stimulations	stimulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 250
# text = Document 00300222 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300222	00300222	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 251
# text = The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 252
# text = The HTLV-I transcriptional activator tax was used to gain insight into the mechanism of lymphotoxin (LT; TNF-beta) gene induction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
12	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 253
# text = Tax-expressing cell lines produce LT biologic activity.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
8	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 254
# text = An LT promoter (LT-293) CAT construct that contained an NF-kappa B site was active in the LT-producing C81-66-45 cell line, which contains defective HTLV-I but expresses tax.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	LT	Lt	ADJ	JJS	Degree=Sup	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LT-	Lt-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	C81-66	C81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-45	-45	NUM	CD	NumType=Card	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
33	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 255
# text = The observation that a mutated LT-kappa B construct (M1-CAT) was inactive in C81-66-45, confirmed the importance of NF-kappa B in LT gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	M1	m1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	C81-66	C81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-45	-45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	LT	LT	PROPN	NNP	Number=Sing	_	_	_	_
32	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 256
# text = Tax was transfected into HTLV-I-negative human T-cell lines.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	into	into	ADP	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 257
# text = Jurkat
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 258
# text = T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa B site.
1	T	t	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	directly	directly	ADV	RB	_	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 259
# text = Tax co-transfected with reporter constructs into Jurkat cells maximally activated HTLV-I-LTR-CAT and kappa B-fos-CAT and also activated LT-293 to a lesser extent.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	maximally	maximally	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-I	-i	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	LTR-	ltr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fos	fos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	293	293	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
32	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 260
# text = In JM
1	In	in	ADP	IN	_	_	_	_	_
2	JM	JM	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 261
# text = T cells, tax induced LT-293 activity by two- to four-fold, though there was no induction of M1-CAT.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	293	293	NUM	CD	NumType=Card	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	four	four	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	though	though	SCONJ	IN	_	_	_	_	_
19	there	there	PRON	EX	_	_	_	_	_
20	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	M1	M1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 262
# text = The increase in LT-293 CAT activity mirrored the increase in LT biologic activity seen under these conditions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	293	293	NUM	CD	NumType=Card	_	_	_	_
7	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	mirrored	mirror	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	LT	LT	PROPN	NNP	Number=Sing	_	_	_	_
14	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 263
# text = These studies, the first to demonstrate induction of LT promoter activity over basal levels, indicate that HTLV-I tax causes low-level activation of both endogenous LT and the LT promoter, at least in part through activation of NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	over	over	ADP	IN	_	_	_	_	_
14	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
23	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	at	at	ADV	RB	_	_	_	_	_
38	least	least	ADV	RBS	Degree=Sup	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	part	part	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
47	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 264
# text = Document 00300223 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300223	00300223	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 265
# text = Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 266
# text = NF-kappa B is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	extrinsic	extrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 267
# text = Our findings show that suppression of NF-kappa B activity with cell-permeable SN50 peptide, which masks the nuclear localization sequence of NF-kappa B1 dimers and prevents their nuclear localization, induces apoptosis in resting normal human PBL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
16	SN50	SN50	NOUN	NN	Number=Sing	_	_	_	_
17	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	masks	mask	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
30	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
38	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	in	in	SCONJ	IN	_	_	_	_	_
40	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
41	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 268
# text = Inhibition of NF-kappa B resulted in the externalization of phosphatidylserine, induction of DNA breaks, and morphological changes consistent with apoptosis.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	externalization	externalization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	phosphatidylserine	phosphatidylserine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 269
# text = DNA fragmentation was efficiently blocked by the caspase inhibitor Z-VAD-fmk and partially blocked by Ac-DEVD-fmk, suggesting that SN50-mediated apoptosis is caspase-dependent.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	efficiently	efficiently	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	Z	z	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	VAD	Vad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	partially	partially	ADV	RB	_	_	_	_	_
17	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	Ac-	Ac-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	DEVD	Devd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	SN50	SN50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 270
# text = Interestingly, apoptosis induced by NF-kappa B suppression, in contrast to that induced by TPEN (N,N,N',N'-tetrakis [2-pyridylmethyl]ethylenediamine) or soluble Fas ligand (CD95), was observed in the absence of active death effector proteases caspase-1-like (IL-1 converting enzyme), caspase-3-like (CPP32/Yama/apopain), and caspase-6-like and without cleavage of caspase-3 substrates poly(ADP-ribose) polymerase and DNA fragmentation factor-45.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TPEN	TPEN	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	N,N,N'	N,N,N'	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
22	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	'	's	PART	POS	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	tetrakis	tetrakis	NOUN	NN	Number=Sing	_	_	_	_
26	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	pyridylmethyl	pyridylmethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	ethylenediamine	ethylenediamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
35	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
36	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	death	death	NOUN	NN	Number=Sing	_	_	_	_
49	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
50	proteases	protease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
51	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	like	like	INTJ	UH	_	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	converting	converting	NOUN	NN	Number=Sing	_	_	_	_
61	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	like	like	INTJ	UH	_	_	_	_	_
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	CPP32/	CPP32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	Yama/	Yama/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
72	apopain	apopain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	-like	-like	ADJ	JJ	Degree=Pos	_	_	_	_
80	and	and	CCONJ	CC	_	_	_	_	_
81	without	without	ADP	IN	_	_	_	_	_
82	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	3	3	NUM	CD	NumType=Card	_	_	_	_
87	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
88	poly	poly	ADV	RB	_	_	_	_	SpaceAfter=No
89	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
90	ADP	Adp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	ribose	ribose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
93	)	)	PUNCT	-RRB-	_	_	_	_	_
94	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
97	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
98	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
99	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
100	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
101	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 271
# text = These findings suggest either low level of activation is required or that different caspases are involved.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	that	that	PRON	WDT	PronType=Dem	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	caspases	caspase	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 272
# text = Preactivation of T cells resulting in NF-kappa B nuclear translocation protected cells from SN50-induced apoptosis.
1	Preactivation	Preactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
13	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	SN50	SN50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 273
# text = Our findings demonstrate an essential role of NF-kappa B in survival of naive PBL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
16	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 274
# text = Document 00300224 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300224	00300224	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 275
# text = Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein.
1	Dysregulation	Dysregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	oxidized	oxidize	ADJ	JJ	Degree=Pos	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	density	density	NOUN	NN	Number=Sing	_	_	_	_
14	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 276
# text = Nuclear factor-kappa B (NF-kappa B)/Rel transcription factors may be involved in atherosclerosis, as is suggested by the presence of activated NF-kappa B in human atherosclerotic lesions.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
37	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 277
# text = The aim of the present study was to investigate the effects of oxidized LDL (oxLDL) on the NF-kappa B system in human THP-1 monocytic cells as well as adherent monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	LDL	LDL	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	oxLDL	oxLDL	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 278
# text = Our results demonstrate that short-term incubation of these cells with oxLDL activated p50/p65 containing NF-kappa B dimers and induced the expression of the target gene IL-8.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	term	term	NOUN	NN	Number=Sing	_	_	_	_
8	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 279
# text = This activation of NF-kappa B was inhibited by the antioxidant and H2O2 scavenger pyrrolidine dithiocarbamate and the proteasome inhibitor PSI.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
15	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
16	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
17	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	PSI	pSi	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 280
# text = The oxLDL-induced NF-kappa B activation was accompanied by an initial depletion of I kappa B-alpha followed by a slight transient increase in the level of this inhibitor protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oxLDL	oxldl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
15	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	ADV	RB	_	_	_	_	_
21	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
25	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 281
# text = In contrast, long-term treatment with oxLDL prevented the lipopolysaccharide-induced depletion of I kappa B-alpha, accompanied by an inhibition of both NF-kappa B activation and the expression of tumor necrosis factor-alpha and interleukin-1 beta genes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
38	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 282
# text = These observations provide additional evidence that oxLDL is a potent modulator of gene expression and suggest that (dys)regulation of NF-kappa B/Rel is likely to play an important role in atherogenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
11	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	dys	dy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	role	role	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 283
# text = Document 00300225 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300225	00300225	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 284
# text = The interleukin-8 AP-1 and kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	8	8	NUM	CD	NumType=Card	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 285
# text = B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	end	end	NOUN	NN	Number=Sing	_	_	_	_
8	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
17	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 286
# text = FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.
1	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 287
# text = We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
5	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
34	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
37	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 288
# text = By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.
1	By	by	ADP	IN	_	_	_	_	_
2	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	like	like	SCONJ	IN	_	_	_	_	_
22	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 289
# text = FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.
1	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
2	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptions	transcription	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	like	like	SCONJ	IN	_	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
19	plus	plus	CCONJ	CC	_	_	_	_	_
20	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	mobilizing	mobilizing	ADJ	JJ	Degree=Pos	_	_	_	_
26	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	Ca	Ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
39	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 290
# text = In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PMA/ionomycin-induced	PMA/ionomycin-induced	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	anti-JunD	anti-jund	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Fos	Fos	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 291
# text = In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	EGTA	EGTA	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	chelator	chelator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	similarly	similarly	ADV	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	any	any	DET	DT	_	_	_	_	_
31	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
32	against	against	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
36	family	family	NOUN	NN	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 292
# text = Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	report	report	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
10	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	PMA/ionomycin-induced	PMA/ionomycin-induced	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	authentic	authentic	ADJ	JJ	Degree=Pos	_	_	_	_
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 293
# text = (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	8	8	NUM	CD	NumType=Card	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	SCONJ	IN	_	_	_	_	_
45	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
46	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 294
# text = Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	at	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NFIL	Nfil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	A	a	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	like	like	SCONJ	IN	_	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
42	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
43	terminals	terminal	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
48	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
49	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
50	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	+	+	SYM	SYM	_	_	_	_	_
52	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 295
# text = Document 00300226 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300226	00300226	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 296
# text = Interactions of a transcriptional activator in the env gene of the mouse mammary tumor virus with activation-dependent, T cell-specific transacting factors.
1	Interactions	Interaction	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	env	env	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	transacting	transacting	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 297
# text = The mouse mammary tumor virus env gene contains a transcriptional activator (META) that can control transcription of the adjacent long terminal repeat region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
3	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	env	env	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 298
# text = Transcriptional control by META parallels that of several lymphokine genes, being specific to T cells, dependent on their activation, and inhibited by the immunosuppressive drug cyclosporine (CsA).
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	META	META	PROPN	NNP	Number=Sing	_	_	_	_
5	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	ADV	WRB	PronType=Rel	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
28	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
29	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 299
# text = DNase I footprinting indicated that nuclear factors from activated T lymphocytes bound a promoter-proximal site, META(P), and a promoter-distal site, META(D+), within the 400-base pair META region.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	bound	bound	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	within	within	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	400	400	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	base	base	NOUN	NN	Number=Sing	_	_	_	_
42	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
43	META	Meof	ADP	IN	Abbr=Yes	_	_	_	_
44	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 300
# text = Nuclear factors from unstimulated, but not from activated cells, bound a site, META(D-), adjacent to META(D+).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bound	bound	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	+)	+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 301
# text = META(D+) directed transcription of a linked luciferase gene, and gel shift analysis revealed binding of inducible, CsA-sensitive T cell factors, in parallel with transfection results.
1	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	D	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
18	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 302
# text = Authentic NFAT and NF-kappaB targets did not compete for the META(D+) binding factor(s).
1	Authentic	authentic	PROPN	NNP	Number=Sing	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	META	METa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	D	d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	s	s	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 303
# text = The SV40 core sequence competed for META(D+) binding factors, but META(D+) failed to compete for the complexes obtained with the SV40 probe.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
3	core	core	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	competed	compet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
27	obtained	obtaine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
31	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 304
# text = Our results, taken together, indicate that META(D+) is a novel transcriptional enhancer element that is similar in its cell-type specificity, activation dependence, and CsA sensitivity to the NFAT element.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
25	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CsA	csa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
40	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 305
# text = It may be relevant to the role of MMTV in expression of Mls antigens or the induction of T cell lymphomas.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Mls	Mls	NOUN	NNS	Number=Plur	_	_	_	_
14	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 306
# text = Document 00300227 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300227	00300227	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 307
# text = Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	upregulate	upregulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 308
# text = BACKGROUND: The immediate early genes (IE) of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IE	ie	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 309
# text = Interleukin-6 (IL-6) plays a central role in numerous inflammatory and immune processes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 310
# text = Interleukin-6 levels are increased in lung transplant patients clinically diagnosed with CMV pneumonitis.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
9	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	clinically	clinically	ADV	RB	_	_	_	_	_
12	diagnosed	diagnose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CMV	Cmv	PROPN	NNP	Number=Sing	_	_	_	_
15	pneumonitis	pneumonitis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 311
# text = The regulation of IL-6 is dependent on various stimuli that include lipopolysaccharide (LPS), viruses, and other cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 312
# text = These studies examined the ability of CMV IE gene products to modulate IL-6 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
8	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	products	product	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 313
# text = METHODS: THP-1 cells, a monocytic cell line, were transfected with the CMV IE genes.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
18	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 314
# text = Interleukin-6 protein and IL-6 mRNA were measured in control and CMV immediate early transfected cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CMV	Cmv	X	GW	_	_	_	_	_
16	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	early	early	ADV	RB	Degree=Pos	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 315
# text = Cotransfection of CMV IE genes and IL-6 chloramphenicol acetyl transferase (CAT) or IL-6 luciferase constructs were used to study IL-6 promoter activity.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
4	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
12	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
21	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 316
# text = RESULTS: Interleukin-6 protein and mRNA production were significantly increased in cells transfected with the CMV IE genes and stimulated with LPS compared to LPS-stimulated control cells.
1	RESULTS	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
19	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 317
# text = Cytomegalovirus
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 318
# text = IE gene products significantly enhanced LPS stimulation of IL-6 promoter activity in both IL-6 CAT and IL-6 luciferase assays.
1	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	products	product	NOUN	NNS	Number=Plur	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 319
# text = A deletion construct that contains a NF-kappa B site but is missing the multiple response region demonstrated a continued increase in IL-6 luciferase activity in LPS-stimulated CMV transfected cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	missing	miss	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	continued	continu	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	CMV	haCmve	NOUN	NN	Number=Sing	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 320
# text = CONCLUSION: Cytomegalovirus immediate early gene products significantly enhanced expression of IL-6 in LPS-stimulated cells.
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 321
# text = The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	area	area	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	6	6	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
37	amp	amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
41	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
43	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
44	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 322
# text = The ability of CMV IE gene products to enhance IL-6 production may play an important role in immune inflammatory states associated with CMV infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
5	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	states	state	NOUN	NNS	Number=Plur	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 323
# text = Document 00300228 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300228	00300228	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 324
# text = Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 325
# text = The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor CD28.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
11	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
14	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	auxiliary	auxiliary	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 326
# text = Several transcription factors participate in IL-2 promoter activation, among which are AP-1-like factors and NF-kappa B. Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun; and (2) it is involved in the release of the cytoplasmic inhibitor, I kappa B, from NF-kappa B, allowing translocation of the latter into the nucleus.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	among	among	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADP	IN	_	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_
27	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
38	two	two	NUM	CD	NumType=Card	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	:	:	PUNCT	:	_	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
45	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
48	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
55	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	;	;	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	2	2	X	LS	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
64	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
65	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
66	in	in	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	release	release	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
72	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	,	,	PUNCT	,	_	_	_	_	_
74	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
75	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
76	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	,	,	PUNCT	,	_	_	_	_	_
78	from	from	ADP	IN	_	_	_	_	_
79	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
80	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
81	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
82	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	,	,	PUNCT	,	_	_	_	_	_
84	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
85	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
86	of	of	ADP	IN	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
89	into	into	ADP	IN	_	_	_	_	_
90	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
91	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
92	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 327
# text = We have recently shown that both phosphorylation processes require T-cell costimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
9	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 328
# text = Furthermore, in activated T cells, the kinetics of the two phosphorylation events are essentially similar.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essentially	essentially	ADV	RB	_	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 329
# text = According to our results, however, the kinases responsible for the two processes are distinct entities.
1	According	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	entities	entity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 330
# text = Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B, it markedly enhances the activity of JNK, the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	_
3	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	markedly	markedly	ADV	RB	_	_	_	_	_
22	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
38	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 331
# text = We, therefore, propose the activation scheme presented in FIGURE 3 for T-cell costimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	propose	propose	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	scheme	scheme	NOUN	NN	Number=Sing	_	_	_	_
9	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	FIGURE	figure	PROPN	NNP	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 332
# text = Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors, AP-1 and NF-kappa B.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 333
# text = Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other.
1	Integration	Integration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
12	along	along	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	then	then	ADV	RB	PronType=Dem	_	_	_	_
18	bifurcates	bifurcate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
43	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
44	on	on	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 334
# text = We are currently engaged in defining where the two signals integrate along the AP-1/NF-kappa B pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	currently	currently	ADV	RB	_	_	_	_	_
4	engaged	engage	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
7	where	where	ADV	WRB	PronType=Int	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	integrate	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
12	along	along	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 335
# text = Document 00300229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300229	00300229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 336
# text = The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	engages	engage	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 337
# text = The Epstein-Barr virus latent membrane protein 1 (LMP1) is essential for the transformation of B lymphocytes into lymphoblastoid cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 338
# text = Previous data are consistent with a model that LMP1 is a constitutively activated receptor that transduces signals for transformation through its carboxyl-terminal cytoplasmic tail.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	constitutively	constitutively	ADV	RB	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	transduces	transduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 339
# text = One transformation effector site (TES1), located within the membrane proximal 45 residues of the cytoplasmic tail, constitutively engages tumor necrosis factor receptor-associated factors.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
3	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TES1	TES1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
14	45	45	NUM	CD	NumType=Card	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	constitutively	constitutively	ADV	RB	_	_	_	_	_
22	engages	engage	NOUN	NNS	Number=Plur	_	_	_	_
23	tumor	tumor	ADP	IN	_	_	_	_	_
24	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 340
# text = Signals from TES1 are sufficient to drive initial proliferation of infected resting B lymphocytes, but most lymphoblastoid cells infected with a virus that does not express the 155 residues beyond TES1 fail to grow as long-term cell lines.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	TES1	tES1	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
8	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	155	155	NUM	CD	NumType=Card	_	_	_	_
30	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
31	beyond	beyond	ADP	IN	_	_	_	_	_
32	TES1	TES1	NUM	CD	NumType=Card	_	_	_	_
33	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	grow	grow	VERB	VB	VerbForm=Inf	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	term	term	NOUN	NN	Number=Sing	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 341
# text = We now find that mutating two tyrosines to an isoleucine at the carboxyl end of the cytoplasmic tail cripples the ability of EBV to cause lymphoblastoid cell outgrowth, thereby marking a second transformation effector site, TES2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mutating	mutat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
14	end	end	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
18	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
19	cripples	cripple	NOUN	NNS	Number=Plur	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
26	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	outgrowth	outgrowth	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thereby	thereby	ADV	RB	_	_	_	_	_
31	marking	mark	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
34	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
35	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	TES2	TES2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 342
# text = A yeast two-hybrid screen identified TES2 interacting proteins, including the tumor necrosis factor receptor-associated death domain protein (TRADD).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
6	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	TES2	TES2	NUM	CD	NumType=Card	_	_	_	_
9	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 343
# text = TRADD was the only protein that interacted with wild-type TES2 and not with isoleucine-mutated TES2.
1	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	TES2	Tes2	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	TES2	Tes2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 344
# text = TRADD associated with wild-type LMP1 but not with isoleucine-mutated LMP1 in mammalian cells, and TRADD constitutively associated with LMP1 in EBV-transformed cells.
1	TRADD	Tradd	NOUN	NN	Number=Sing	_	_	_	_
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	isoleucine-mutated	isoleucine-mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 345
# text = In transfection assays, TRADD and TES2 synergistically mediated high-level NF-kappaB activation.
1	In	in	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	TRADD	Tradd	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TES2	TES2	NUM	CD	NumType=Card	_	_	_	_
8	synergistically	synergistically	ADV	RB	_	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 346
# text = These results indicate that LMP1 appropriates TRADD to enable efficient long-term lymphoblastoid cell outgrowth.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
6	appropriates	appropriate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enable	enable	VERB	VB	VerbForm=Inf	_	_	_	_
10	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	term	term	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 347
# text = High-level NF-kappaB activation also appears to be a critical component of long-term outgrowth.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	component	component	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 348
# text = Document 00300230 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300230	00300230	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 349
# text = ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.
1	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 350
# text = We describe an enhancer site in the third intron of tumor necrosis factor alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 351
# text = A reporter construct containing the 5'-flanking region of the mouse TNF-alpha gene displayed weak activity when transfected into RAW264.7 macrophage-like cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
3	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	when	when	ADV	WRB	PronType=Int	_	_	_	_
22	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	into	into	ADP	IN	_	_	_	_	_
24	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 352
# text = The addition of the third intron of TNF-alpha to this construct resulted in an enhancement of CAT protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
14	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 353
# text = This enhancement was eliminated if a conserved 20-bp sequence was removed from the intron or if a dominant-negative ets-binding factor was co-transfected with the reporter gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	if	if	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	removed	remove	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	if	if	SCONJ	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
23	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 354
# text = Mutations of this site that destroyed potential ets transcription factor binding sites had reduced transcriptional activity.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	destroyed	destroy	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
8	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 355
# text = The major transcription factor that bound to the oligonucleotide was confirmed to be GABP by supershift and competition analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 356
# text = In RAW264.7 cells, the binding was constitutive, however, in bone marrow-derived macrophages binding activity was shown to be interferon-gamma inducible.
1	In	in	ADP	IN	_	_	_	_	_
2	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
15	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	interferon	interferon	ADP	IN	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 357
# text = This may imply a role for ets transcription factors in the production of TNF-alpha.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	imply	imply	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 358
# text = Document 00300231 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300231	00300231	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 359
# text = Xenogeneic human serum promotes leukocyte adhesion to porcine endothelium under flow conditions, possibly through the activation of the transcription factor NF-kappa B.
1	Xenogeneic	Xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
4	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	porcine	porcine	VERB	VB	VerbForm=Inf	_	_	_	_
9	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
12	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	possibly	possibly	ADV	RB	_	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 360
# text = Endothelial cell activation and leukocyte infiltration are a consistent feature of discordant xenograft rejection.
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
6	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	discordant	discordant	ADJ	JJ	Degree=Pos	_	_	_	_
13	xenograft	xenograft	NOUN	NN	Number=Sing	_	_	_	_
14	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 361
# text = Here we evaluated whether xenogeneic serum, as a source of xenoreactive natural antibodies and complement, induced endothelial cell activation with consequent leukocyte adhesion under flow conditions.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
6	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	source	source	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	xenoreactive	xenoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	complement	complement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
28	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 362
# text = Porcine aortic endothelial cells (PAEC) were incubated for 1 hr 30 min or 5 hr with 10% homologous porcine serum (control) or 10% xenogeneic human serum and then perfused with total human leukocytes in a parallel plate flow chamber under laminar flow (1.5 dynes/cm2).
1	Porcine	Porcine	PROPN	NNP	Number=Sing	_	_	_	_
2	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
22	porcine	porcine	NOUN	NN	Number=Sing	_	_	_	_
23	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	%	%	SYM	NN	Number=Sing	_	_	_	_
30	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	then	then	ADV	RB	PronType=Dem	_	_	_	_
35	perfused	perfuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
43	plate	plate	NOUN	NN	Number=Sing	_	_	_	_
44	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
45	chamber	chamber	NOUN	NN	Number=Sing	_	_	_	_
46	under	under	ADP	IN	_	_	_	_	_
47	laminar	laminar	ADJ	JJ	Degree=Pos	_	_	_	_
48	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	1.5	1.5	NUM	CD	NumType=Card	_	_	_	_
51	dynes	dyne	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
53	cm2	cm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 363
# text = Adherent cells were counted by digital image analysis.
1	Adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	counted	count	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	digital	digital	ADJ	JJ	Degree=Pos	_	_	_	_
7	image	image	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 364
# text = Xenogeneic human serum significantly (P < 0.01) increased the number of adherent leukocytes as compared with porcine serum.
1	Xenogeneic	Xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	NOUN	NN	Number=Sing	_	_	_	_
7	<	<	PUNCT	-LRB-	_	_	_	_	_
8	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	porcine	porcine	NOUN	NN	Number=Sing	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 365
# text = A similar adhesive response was elicited by TNF alpha (100 U/ml), one of the most potent inducers of endothelial cell adhesive properties, here used as positive control.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	100	100	NUM	CD	NumType=Card	_	_	_	_
12	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
21	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
26	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	here	here	ADV	RB	PronType=Dem	_	_	_	_
29	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 366
# text = In order to elucidate possible mechanisms underlying endothelial cell activation by xenogeneic serum, we focussed on transcription factor NF-kappa B, a central regulator for the induction of different genes, including adhesive molecules and chemoattractants.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	focussed	focuss	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
36	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	chemoattractants	chemoattractant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 367
# text = By confocal fluorescence microscopy, we observed a positive staining for NF-kappa B (p65 subunit) in the nuclei of PAEC exposed for 1 hr 30 min to human serum, which indicated NF-kappa B activation in this setting.
1	By	by	ADP	IN	_	_	_	_	_
2	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
3	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
4	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p65	p65	NUM	CD	NumType=Card	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
25	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
29	30	30	NUM	CD	NumType=Card	_	_	_	_
30	min	min	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	setting	setting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 368
# text = At variance, in PAEC incubated with the homologous serum, NF-kappa B was strictly localized in the cell cytoplasm.
1	At	at	ADP	IN	_	_	_	_	_
2	variance	variance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
6	incubated	incubate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	strictly	strictly	ADV	RB	_	_	_	_	_
18	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 369
# text = Treatment of PAEC exposed to xenogeneic serum with the NF-kappa B inhibitors pyrrolidinedithiocarbamate (PDTC, 25 microM) and tosyl-phechloromethylketone (TPCK, 25 microM) significantly (P < 0.01) reduced leukocyte adhesion in respect to PAEC treated with human serum alone.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
7	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
15	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	25	25	NUM	CD	NumType=Card	_	_	_	_
20	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	tosyl	tosyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	phechloromethylketone	phechloromethylketone	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	25	25	NUM	CD	NumType=Card	_	_	_	_
30	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	significantly	significantly	ADV	RB	_	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	P	p	NOUN	NN	Number=Sing	_	_	_	_
35	<	<	PUNCT	-LRB-	_	_	_	_	_
36	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
45	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
49	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 370
# text = Findings that xenogeneic serum promotes leukocyte-endothelium interaction possibly through NF-kappa B activation might be relevant for designing future therapeutic strategies aimed at prolonging xenograft survival.
1	Findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	SCONJ	IN	_	_	_	_	_
3	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
4	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	possibly	possibly	ADV	RB	_	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	designing	design	VERB	VBG	VerbForm=Ger	_	_	_	_
22	future	future	ADJ	JJ	Degree=Pos	_	_	_	_
23	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
24	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
25	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	at	at	SCONJ	IN	_	_	_	_	_
27	prolonging	prolonge	VERB	VBG	VerbForm=Ger	_	_	_	_
28	xenograft	xenograft	NOUN	NN	Number=Sing	_	_	_	_
29	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 371
# text = Document 00300232 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300232	00300232	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 372
# text = Epstein-Barr virus replicative gene transcription during de novo infection of human thymocytes: simultaneous early expression of BZLF-1 and its repressor RAZ.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	de	de	PROPN	NNP	Number=Sing	_	_	_	_
10	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
26	RAZ	Raz	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 373
# text = Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 374
# text = We and others have shown that EBV can also infect a subset of thymocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 375
# text = Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
11	EBV	EBV	NOUN	NN	Number=Sing	_	_	_	_
12	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 376
# text = Circularization of the EBV genome was not detected.
1	Circularization	Circularization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
5	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 377
# text = This is in contrast to the infection in B cells where the genome can circularize within 24 hr of infection.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	where	where	ADV	WRB	PronType=Rel	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	circularize	circularize	VERB	VB	VerbForm=Inf	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	24	24	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 378
# text = The appearance of the BamHI ZLF-1 gene product, ZEBRA, by RT-PCR, was observed within 8 hr of infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
6	ZLF	ZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 379
# text = The appearance of a novel fusion transcript (RAZ), which comprised regions of the BZLF-1 locus and the adjacent BRLF-1 locus, was detected by RT-PCR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RAZ	RAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	comprised	comprise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
24	BRLF	BRLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 380
# text = ZEBRA protein was also identified in infected thymocytes by immunoprecipitation.
1	ZEBRA	zebra	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 381
# text = In addition, we demonstrated that the EBNA-1 gene in infected thymocytes was transcribed from the Fp promoter, rather than from the Cp/Wp promoter which is used in latently infected B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	infected	infected	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Fp	Fp	PROPN	NNP	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	rather	rather	ADV	RB	_	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Cp/	cp/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	Wp	Wp	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	latently	latently	ADV	RB	_	_	_	_	_
34	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 382
# text = Transcripts encoding gp350/220, the major coat protein of EBV, were identified, but we did not find any evidence of transcription from the LMP-2A or EBER-1 loci in infected thymocytes.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
3	gp350	gp350	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
5	220	220	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	coat	coat	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
22	any	any	DET	DT	_	_	_	_	_
23	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	EBER	EBER	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
38	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 383
# text = These observations suggest that de novo EBV infection of thymocytes differs from infection of B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	de	de	PROPN	NNP	Number=Sing	_	_	_	_
6	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 384
# text = The main difference is that with thymocytes, no evidence could be found that the virus ever circularizes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	ever	ever	ADV	RB	_	_	_	_	_
18	circularizes	circularize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 385
# text = Rather, EBV remains in a linear configuration from which replicative genes are transcribed.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
8	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 386
# text = Document 00300233 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300233	00300233	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 387
# text = Second messenger up-regulation of androgen receptor gene transcription is absent in androgen insensitive human prostatic carcinoma cell lines, PC-3 and DU-145.
1	Second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
3	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	androgen	androgen	NUM	CD	NumType=Card	_	_	_	_
15	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
18	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	DU	du	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	145	145	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 388
# text = A theoretical pathway of transcriptional regulation of the androgen receptor (AR) gene is via a cAMP response element (CRE) present in its promoter region (-508 to -501).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	theoretical	theoretical	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	AR	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	region	region	NOUN	NN	Number=Sing	_	_	_	_
29	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
30	508	508	NUM	CD	NumType=Card	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	501	501	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 389
# text = After 20 h of stimulation with 8-bromo-cAMP, AR mRNA was upregulated in LNCaP but not in either PC-3 or DU-145 cell lines.
1	After	after	ADP	IN	_	_	_	_	_
2	20	20	NUM	CD	NumType=Card	_	_	_	_
3	h	h	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	bromo-cAMP	bromo-camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AR	ar	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LNCaP	LNCaP	NOUN	NN	Number=Sing	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	either	either	DET	DT	_	_	_	_	_
21	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	DU	do	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	145	145	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 390
# text = We have demonstrated that the level of CRE binding protein (CREB) was the same in all cell lines and that the putative AR-CRE forms specific and compatible protein interactions with CREB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	all	all	DET	DT	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
25	AR	ar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
28	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 391
# text = The ability to regulate AR gene transcription via the second messenger pathway is lost in the PC-3 and DU-145 cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
5	AR	be	ADP	IN	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	DU	do	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	145	145	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 392
# text = This may be an important primary mechanism of androgen insensitivity in prostate cancer.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
10	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	prostate	prostate	ADJ	JJ	Degree=Pos	_	_	_	_
13	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 393
# text = Document 00300234 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300234	00300234	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 394
# text = Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	vanadate	vanadate	ADJ	JJ	Degree=Pos	_	_	_	_
11	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 395
# text = Rapid tyrosine phosphorylation of key cellular proteins is a crucial event in the transduction of activation signals to T-lymphocytes.
1	Rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
11	event	event	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 396
# text = The regulatory role of protein tyrosine phosphatases (PTPases) in this process was explored by studying the effects of a powerful PTPase inhibitor, vanadate peroxide (pervanadate), on the activation cascade of Jurkat human leukaemic T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PTPases	PTPase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	process	process	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
23	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
24	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
27	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukaemic	leukaemic	ADJ	JJ	Degree=Pos	_	_	_	_
40	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 397
# text = Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in tyrosine phosphorylation of cellular proteins, notably phospholipase C gamma 1.
1	Pervanadate	Pervanadate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	fyn	fyn	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	notably	notably	ADV	RB	_	_	_	_	_
32	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	_
34	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 398
# text = After this event, we observed a rise in intracellular Ca2+ concentration, corresponding to an influx.
1	After	after	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 399
# text = This effect required surface expression of the CD45 PTPase and was not observed in CD45-deficient variants of Jurkat cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
9	PTPase	PTPase	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 400
# text = In the CD45-negative variant, the effect of pervanadate on tyrosine phosphorylation was globally decreased and some phosphorylated substrates were specifically missing.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	CD45	Cd45	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	variant	variant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	globally	globally	ADV	RB	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	missing	missing	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 401
# text = Pervanadate also stimulated transcription of the c-fos gene and accumulation of its mRNA as well as several other hallmarks of T-lymphocyte activation such as surface expression of the CD69 antigen and the interleukin 2 receptor alpha-chain (CD25).
1	Pervanadate	Pervanadate	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	hallmarks	hallmark	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	CD69	CD69	PROPN	NNP	Number=Sing	_	_	_	_
33	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	CD25	CD25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 402
# text = Pervanadate synergized with signals delivered by T-cell antigen receptor engagement or by a phorbol ester to induce interleukin 2 production.
1	Pervanadate	Pervanadate	NOUN	NN	Number=Sing	_	_	_	_
2	synergized	synergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
16	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	interleukin	interleukin	ADV	RB	_	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 403
# text = Pervanadate activated NF-kappa B, as shown by an increase in DNA-binding activity of this transcription factor.
1	Pervanadate	Pervanadate	PROPN	NNP	Number=Sing	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 404
# text = We thus conclude that PTPases play a crucial role in the negative regulation of signal transduction culminating in T-lymphocyte activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	thus	thus	ADV	RB	_	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PTPases	PTPase	PROPN	NNPS	Number=Plur	_	_	_	_
6	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	culminating	culminat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 405
# text = Moreover, induction of tyrosine phosphorylation appears sufficient per se to initiate a complete activation programme.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	per	per	ADP	IN	_	_	_	_	_
10	se	se	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	programme	programme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 406
# text = Document 00300235 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300235	00300235	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 407
# text = Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells.
1	Relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 408
# text = In order to understand the role of NF-kappaB in EBV transformation we have established stably transfected IkappaBalpha into lymphoblastoid cells.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
13	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	into	into	ADP	IN	_	_	_	_	_
21	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 409
# text = Two clones were obtained in which the loss of NF-kappaB binding activity correlated with the constitutive expression of the transgenic IkappaBalpha.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
23	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 410
# text = Protein latency expression was determined by immunocytochemistry.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 411
# text = Expression of surface markers, intracytoplasmic content of cytokines cell cycle analysis after BrdU incorporation and DNA staining with propidium iodide were studied by flow cytometry.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
4	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	content	content	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	BrdU	Brdu	PROPN	NNP	Number=Sing	_	_	_	_
15	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	propidium	propidium	NOUN	NN	Number=Sing	_	_	_	_
21	iodide	iodide	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
26	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 412
# text = Percentage of apoptotic cells was determined by in-situ labelling of DNA strand breaks.
1	Percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
11	labelling	labelling	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
15	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 413
# text = No significative changes in EBV latency nor in cell surface marker expression was found.
1	No	no	DET	DT	_	_	_	_	_
2	significative	significative	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	latency	latency	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 414
# text = In contrast, intracytoplasmic TNFalpha levels were strongly reduced in transfected clones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
5	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 415
# text = Furthermore, 30% of IkappaBalpha transfected cells were apoptotic after 8 h of TNFalpha treatment.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	%	%	SYM	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 416
# text = This correlated with a strong reduction of BrdU incorporation after 24 h of TNFalpha treatment.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	BrdU	BrdU	PROPN	NNP	Number=Sing	_	_	_	_
9	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	24	24	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 417
# text = No effect was seen with non transfected cells or with cells transfected with a control plasmid.
1	No	no	DET	DT	_	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	non	non	X	AFX	_	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 418
# text = Our results suggest that the TNFalpha gene could be one of the targets of NF-kappaB in EBV infected cells and that NF-kappaB protects EBV-infected cells from apoptosis induced by TNFalpha, which may favour the proliferative effect of this cytokine.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TNFalpha	TNFalpha	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	one	one	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	protects	protects	NOUN	NNS	Number=Plur	_	_	_	_
28	EBV	haEbve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	favour	favour	VERB	VB	VerbForm=Inf	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
43	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
46	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 419
# text = Document 00300236 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300236	00300236	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 420
# text = High molecular weight dextran sulfate increases the activity of NF-kappaB-regulated promoter in monocyte-derived macrophages.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
4	dextran	dextrun	NOUN	NN	Number=Sing	_	_	_	_
5	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
6	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 421
# text = It is known that sulfated polysaccharides can mimic the action of common T-cell mitogens.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	sulfated	sulfate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	polysaccharides	polysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 422
# text = To investigate the molecular basis of the mitogenic effect of high molecular weight dextran sulfate (HMDS), monocyte-derived macrophages were transfected with recombinant plasmid containing chloramphenicol acetyl transferase (CAT) reporter gene under the control of the HIV-1 long terminal repeat (LTR) promoter, which is regulated by transcription factor NF-kappaB.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
14	dextran	dextran	NOUN	NN	Number=Sing	_	_	_	_
15	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HMDS	hmds	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
28	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
29	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
31	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
32	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	control	control	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
47	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
48	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	which	which	PRON	WDT	PronType=Rel	_	_	_	_
55	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
59	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
60	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 423
# text = We observed that HMDS, similar to bacterial lipopolysaccharide (LPS), increases the expression of CAT reporter gene suggesting increased activity of NF-kappaB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HMDS	HMDS	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	suggesting	suggeste	VERB	VBG	VerbForm=Ger	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 424
# text = The activation of NF-kappaB correlated with the increased expression of B7.1 molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B7.1	B7.1	NUM	CD	NumType=Card	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 425
# text = It was postulated that this NF-kappaB-regulated promoter might play a role in the activation of the accessory cells as well as the rate of replication of HIV-1 in monocyte-derived macrophages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB-	kappaB-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 426
# text = Document 00300237 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300237	00300237	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 427
# text = Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels.
1	Monoclonal	Monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-endothelial	anti-endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
10	arteritis	arteritis	PROPN	NNPS	Number=Plur	_	_	_	_
11	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
16	vessels	vessel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 428
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 429
# text = To create monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis to evaluate their ability to activate human umbilical vein endothelial cells (HUVEC), and to characterize the mechanism of EC activation.
1	To	to	PART	TO	_	_	_	_	_
2	create	create	VERB	VB	VerbForm=Inf	_	_	_	_
3	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	anti-endothelial	anti-endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	mAECA	mAECa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
15	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
24	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 430
# text = METHODS: A panel of mAECA was generated from peripheral blood lymphocytes of a patient with Takayasu arteritis, using Epstein-Barr virus transformation.
1	METHODS	methods	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
18	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 431
# text = Activity against macrovascular EC (HUVEC) and microvascular EC (human bone marrow EC immortalized by SV40) antigens was detected by enzyme-linked immunosorbent assay.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	against	against	ADP	IN	_	_	_	_	_
3	macrovascular	macrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
4	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	microvascular	microvascular	ADJ	JJ	Degree=Pos	_	_	_	_
10	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
14	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
27	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 432
# text = Inhibition studies were used to select the monoclonal antibodies (mAECA) which share the same EC epitope binding specificity as the total IgG-AECA from the Takayasu arteritis patient.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	select	select	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	EC	Ec	NOUN	NN	Number=Sing	_	_	_	_
18	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
24	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	AECA	AECA	PROPN	NNP	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
30	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
31	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 433
# text = The binding of the mAECA to human aortic EC was studied by immunohistochemistry.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mAECA	mAECa	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	human	human	VERB	VB	VerbForm=Inf	_	_	_	_
8	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 434
# text = The secretion levels of interleukin-6 (IL-6) and von Willebrand factor (vWF) were determined, to serve as markers for EC activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	von	von	PROPN	NNP	Number=Sing	_	_	_	_
15	Willebrand	Willebrand	PROPN	NNP	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	vWF	vWF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 435
# text = The activated EC were examined for the adherence of a monocytic cell line (U937), as well as for expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and E-selectin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 436
# text = In addition, nuclear extracts of the mAECA-treated EC were analyzed for the induction of translocation of nuclear factor kappaB (NF-kappaB), using a specific NF-kappaB oligoprobe in an electrophoretic mobility shift assay.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	oligoprobe	oligoprobe	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
39	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
40	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
41	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 437
# text = RESULTS: Six mAECA were selected, the mixture of which produced 100% inhibition of binding of the original IgG (from the patient with Takayasu arteritis) to HUVEC.
1	RESULTS	results	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Six	six	NUM	CD	NumType=Card	_	_	_	_
4	mAECA	maecan	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	original	original	ADJ	JJ	Degree=Pos	_	_	_	_
21	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
28	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 438
# text = All mAECA possessed high activity against macrovascular EC, but none had significant antimicrovascular EC activity.
1	All	all	DET	DT	_	_	_	_	_
2	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	_
3	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	macrovascular	macrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	none	none	NOUN	NN	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	antimicrovascular	antimicrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 439
# text = The mAECA, but not normal human IgG, had anti-human aortic EC activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IgG	Igg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
12	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
13	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 440
# text = Four of the 6 mAECA activated EC, manifested by increased IL-6 and vWF secretion.
1	Four	four	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	vWF	vwf	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 441
# text = The 4 mAECA induced EC expression of adhesion molecules and increased adhesion of U937 monocytic cells to EC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 442
# text = In addition, these mAECA stimulated the nuclear translocation of the NF-kappaB transcription factor.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
6	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 443
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 444
# text = Our findings suggest that AECA may directly stimulate EC in Takayasu arteritis through elevation of adhesion molecule expression associated with NF-kappaB activation and adhesion of monocytes, and may therefore play a pathogenic role in the development of the vasculopathy in Takayasu arteritis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AECA	AECA	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
12	arteritis	arteritis	ADV	RB	_	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	therefore	therefore	ADV	RB	_	_	_	_	_
33	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	development	development	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
45	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 445
# text = Document 00300238 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300238	00300238	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 446
# text = Possible differences in the mechanism(s) of action of different glucocorticoid hormone compounds.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	s	s	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 447
# text = Different glucocorticoid hormones (GCH) show differences in the intensity and in the kinetics of their immunomodulating activity.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GCH	GCH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	immunomodulating	immunomodulating	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 448
# text = The mechanism(s) of action of GCH is under investigation, but is has been noted that they exert immune activity via the genomic pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	GCH	GCH	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 449
# text = We have studied the effects of prednisone (PDN), deflazacort (DFC), and dexamethasone (DXM) on the production of cytokines (IL-2, IL-6, TNF-alpha, IL-10) by peripheral T lymphocytes, and the effects on the inhibition of NF-kB DNA binding activity by activated Jurkat cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	prednisone	prednisone	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PDN	PDN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	deflazacort	deflazacort	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DFC	DFC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	DXM	DXM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
52	on	on	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
59	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
60	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
62	by	by	ADP	IN	_	_	_	_	_
63	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
64	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
65	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
66	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 450
# text = The data obtained show that the three GCH molecules exert an immunosuppression on cytokine production by T lymphocytes and a strong decrease in the nuclear translocation of NF-kB in Jurkat cells; moreover, (a) not all the cytokines investigated were affected, and not with the same intensity, by the three GCH and (b) DXM inhibited the binding activity of NF-kB less than that of DFC and PDN.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	;	;	PUNCT	,	_	_	_	_	_
35	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	a	a	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	all	all	DET	PDT	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
44	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	not	not	ADV	RB	_	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
53	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	three	three	NUM	CD	NumType=Card	_	_	_	_
58	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	b	b	X	LS	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	DXM	DXm	PRON	PRP	Case=Acc|Gender=Masc|Number=Sing|Person=3|PronType=Prs	_	_	_	_
64	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
67	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
72	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
73	than	than	ADP	IN	_	_	_	_	_
74	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
75	of	of	ADP	IN	_	_	_	_	_
76	DFC	DFC	PROPN	NNP	Number=Sing	_	_	_	_
77	and	and	CCONJ	CC	_	_	_	_	_
78	PDN	PDN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 451
# text = These data are in agreement with the concept that different GCH compounds might differ in their binding and affinity properties, tissue-specific metabolism, and interaction with transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	concept	concept	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	ADV	WRB	PronType=Rel	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
12	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 452
# text = Document 00300239 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300239	00300239	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 453
# text = Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
15	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 454
# text = Numerous cellular and biochemical abnormalities in immune regulation have been described in patients with systemic lupus erythematosus (SLE), including surface
1	Numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
5	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
17	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	SLE	Sle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 455
# text = Ag receptor-initiated signaling events and lymphokine production.
1	Ag	ag	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
6	events	event	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 456
# text = Because NF-kappa B contributes to the transcription of numerous inflammatory genes and has been shown to be a molecular target of antiinflammatory drugs, we sought to characterize the functional role of the NF-kappa B protein complex in lupus T cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	target	target	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	lupus	lupus	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 457
# text = Freshly isolated T cells from lupus patients, rheumatoid arthritis (RA) patients, and normal individuals were activated physiologically via the TCR with anti-CD3 and anti-CD28
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	physiologically	physiologically	ADV	RB	_	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 458
# text = Abs to assess proximal membrane signaling, and with PMA and a calcium ionophore (A23187) to bypass membrane-mediated signaling events.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
4	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
14	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	bypass	bypass	VERB	VB	VerbForm=Inf	_	_	_	_
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 459
# text = We measured the NF-kappa B binding activity in nuclear extracts by gel shift analysis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
15	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 460
# text = When compared with normal cells, the activation of NF-kappa B activity in SLE patients was significantly decreased in SLE, but not in RA, patients.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 461
# text = NF-kappa B binding activity was absent in several SLE patients who were not receiving any medication, including corticosteroids.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	SLE	Sle	PROPN	NNP	Number=Sing	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	who	who	PRON	WP	PronType=Rel	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
17	any	any	DET	DT	_	_	_	_	_
18	medication	medication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	corticosteroids	corticosteroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 462
# text = Also, NF-kappa B activity remained absent in follow-up studies.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	absent	absent	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	follow	follow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	up	up	NOUN	NN	Number=Sing	_	_	_	_
14	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 463
# text = In supershift experiments using specific Abs, we showed that, in the group of SLE patients who displayed undetectable NF-kappa B activity, p65 complexes were not formed.
1	In	in	ADP	IN	_	_	_	_	_
2	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	group	group	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	who	who	PRON	WP	PronType=Rel	_	_	_	_
19	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 464
# text = Finally, immunoblot analysis of nuclear extracts showed decreased or absent p65 protein levels.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	p65	p65	NUM	CD	NumType=Card	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 465
# text = As p65 complexes are transcriptionally active in comparison to the p50 homodimer, this novel finding may provide insight on the origin of abnormal cytokine or other gene transcription in SLE patients.
1	As	as	ADP	IN	_	_	_	_	_
2	p65	p65	NUM	CD	NumType=Card	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
16	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 466
# text = Document 00300240 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300240	00300240	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 467
# text = cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
1	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 468
# text = We demonstrate that JunD, a component of the AP-1 transcription factor complex, activates transcription of the human proenkephalin gene in a fashion that is completely dependent upon the cAMP-dependent protein kinase, protein kinase A.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	component	component	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	completely	completely	ADV	RB	_	_	_	_	_
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	upon	upon	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	A	A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 469
# text = Activation of proenkephalin transcription by JunD is dependent upon a previously characterized cAMP-, phorbol ester-, and Ca(2+)-inducible enhancer, and JunD is shown to bind the enhancer as a homodimer.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Ca	Ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 470
# text = Another component of the AP-1 transcription complex, JunB, is shown to inhibit activation mediated by JunD.
1	Another	another	DET	DT	_	_	_	_	_
2	component	component	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 471
# text = As a homodimer JunB is unable to bind the enhancer; however in the presence of c-Fos, high-affinity binding is observed.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
4	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 472
# text = Furthermore, JunD is shown to activate transcription of genes linked to both cAMP and phorbol ester response elements in a protein kinase A-dependent fashion, further blurring the distinction between these response elements.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	further	further	SCONJ	IN	_	_	_	_	_
30	blurring	blurre	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	distinction	distinction	NOUN	NN	Number=Sing	_	_	_	_
33	between	between	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 473
# text = These results demonstrate that the transcriptional activity of an AP-1-related protein is regulated by the cAMP-dependent second-messenger pathway and suggest that JunD and other AP-1-related proteins may play an important role in the regulation of gene expression by cAMP-dependent intracellular signaling pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
54	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
55	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
56	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 474
# text = Document 00300241 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300241	00300241	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 475
# text = Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 476
# text = We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
56	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 477
# text = Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	or	or	CCONJ	CC	_	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	only	only	ADV	RB	_	_	_	_	_
30	one	one	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
34	seemed	seem	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 478
# text = The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
4	concerned	concern	ADJ	JJ	Degree=Pos	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	1	1	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	73	73	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	;	;	PUNCT	,	_	_	_	_	_
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	element	element	NOUN	NN	Number=Sing	_	_	_	_
35	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	between	between	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	181	181	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	73	73	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	which	which	PRON	WDT	PronType=Rel	_	_	_	_
44	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	response	response	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
57	negatively	negatively	ADV	RB	_	_	_	_	SpaceAfter=No
58	;	;	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	3	3	X	LS	_	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
63	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
64	element	element	NOUN	NN	Number=Sing	_	_	_	_
65	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
68	224	224	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	which	which	PRON	WDT	PronType=Rel	_	_	_	_
71	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
72	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
73	by	by	ADP	IN	_	_	_	_	_
74	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
77	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 479
# text = LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
7	NF	NF	ADP	RP	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 480
# text = Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	_
34	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
37	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
41	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
45	control	control	NOUN	NN	Number=Sing	_	_	_	_
46	element	element	NOUN	NN	Number=Sing	_	_	_	_
47	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	6	6	NUM	CD	NumType=Card	_	_	_	_
53	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 481
# text = This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
3	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 482
# text = Document 00300242 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300242	00300242	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 483
# text = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	member	member	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
32	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 484
# text = Receptor activator of NF-kappaB (RANK) is a recently identified member of the tumor necrosis factor receptor superfamily and is expressed on activated T cells and dendritic cells.
1	Receptor	Receptor	NOUN	NN	Number=Sing	_	_	_	_
2	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	superfamily	superfamily	ADV	RB	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 485
# text = Its cognate ligand (RANKL) plays significant roles in the activation of dendritic cell function and osteoclast differentiation.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
3	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	RANKL	RANKL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	osteoclast	osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 486
# text = We demonstrate here the interaction of RANK with tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 both in vitro and in cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TRAFs	Trafs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	both	both	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 487
# text = Mapping of the structural requirements for TRAF/RANK interaction revealed multiple TRAF binding sites clustered in two distinct domains in the RANK cytoplasmic tail.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	TRAF	TRAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	TRAF	Traf	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	clustered	cluster	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 488
# text = These TRAF binding domains were shown to be functionally important for the RANK-dependent induction of NF-kappaB and c-Jun NH2-terminal kinase activities.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	functionally	functionally	ADV	RB	_	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	RANK	Rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c	care	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-terminal	-terminal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 489
# text = Site-directed mutagenesis demonstrated that these TRAF binding sites exhibited selective binding for different TRAF proteins.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	mutagenesis	mutagenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	exhibited	exhibite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	TRAF	TRAF	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 490
# text = In particular, TRAF6 interacted with membrane-proximal determinants distinct from those binding TRAFs 1, 2, 3, and 5.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TRAF6	Traf6	PROPN	NNP	Number=Sing	_	_	_	_
5	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
10	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TRAFs	TRAFs	ADV	RB	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 491
# text = When this membrane-proximal TRAF6 interaction domain was deleted, RANK-mediated NF-kappaB signaling was completely inhibited while c-Jun NH2-terminal kinase activation was partially inhibited.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	RANK	Rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	completely	completely	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	partially	partially	ADV	RB	_	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 492
# text = An NH2-terminal truncation mutant of TRAF6 inhibited RANKL-mediated NF-kappaB activation, but failed to affect constitutive signaling induced by receptor overexpression, revealing a selective role for TRAF6 in ligand-induced activation events.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	RANKL	Rankl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	ligand	ligand	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 493
# text = Document 00300243 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300243	00300243	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 494
# text = Monocytic cell type-specific transcriptional induction of collagenase.
1	Monocytic	Monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 495
# text = Interstitial collagenase (MMP-1), a metalloproteinase produced by resident and inflammatory cells during connective tissue turnover, cleaves type I collagen fibrils.
1	Interstitial	Interstitial	ADJ	JJ	Degree=Pos	_	_	_	_
2	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	MMP	Mmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
11	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	resident	resident	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	connective	connective	ADJ	JJ	Degree=Pos	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
20	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	cleaves	cleave	NOUN	NNS	Number=Plur	_	_	_	_
23	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	collagen	collagen	ADJ	JJ	Degree=Pos	_	_	_	_
26	fibrils	fibril	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 496
# text = This catalytic event is rate limiting in remodeling of tissues rich in fibrillar collagen such as the skin and lungs.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
6	limiting	limit	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	fibrillar	fibrillar	ADJ	JJ	Degree=Pos	_	_	_	_
14	collagen	collagen	NOUN	NNS	Number=Plur	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 497
# text = The regulation of collagenase expression is cell-type specific; bacterial LPS and zymosan, a yeast cell wall derivative, are potent inducers of collagenase expression in macrophages, but do not alter fibroblast collagenase expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	yeast	yeast	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
21	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
36	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
37	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 498
# text = Since promoter elements controlling collagenase transcription in monocytic cells have not been previously defined, we sought to delineate responsive cis-acting elements of the collagenase promoter in transiently transfected human (U937) and murine (J774) monocytic cell lines.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
5	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
23	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	transiently	transiently	ADV	RB	_	_	_	_	_
30	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	human	human	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	J774	J774	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 499
# text = Deletion constructs containing as little as 72 bp of 5' -flanking sequence of the collagenase promoter were sufficient for LPS- or zymosan-mediated transcriptional induction, whereas phorbol inducibility exhibited an absolute requirement for upstream elements including the polyoma enhancer A-binding protein-3 site (-83 to -91) and TTCA sequence (-102 to -105) in both monocytic cells and fibroblasts.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	72	72	NUM	CD	NumType=Card	_	_	_	_
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	_
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
33	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
34	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	absolute	absolute	ADJ	JJ	Degree=Pos	_	_	_	_
37	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
41	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	polyoma	polyoma	NOUN	NN	Number=Sing	_	_	_	_
44	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
45	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	3	3	NUM	CD	NumType=Card	_	_	_	_
51	site	site	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	-83	-83	NUM	CD	NumType=Card	_	_	_	_
54	to	to	ADP	IN	_	_	_	_	_
55	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
56	91	91	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	TTCA	Ttca	PROPN	NNP	Number=Sing	_	_	_	_
60	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
61	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
62	102	102	NUM	CD	NumType=Card	_	_	_	_
63	to	to	ADP	IN	_	_	_	_	_
64	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
65	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	)	)	PUNCT	-RRB-	_	_	_	_	_
67	in	in	ADP	IN	_	_	_	_	_
68	both	both	DET	DT	_	_	_	_	_
69	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
70	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
71	and	and	CCONJ	CC	_	_	_	_	_
72	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
73	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 500
# text = Mutagenesis of the activator protein-1 [AP-1] site at -72 abolished basal promoter activity and LPS/zymosan inducibility, while mutagenesis of an NF-kappaB-like site at -20 to -10 had no effect.
1	Mutagenesis	Mutagenesis	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	72	72	NUM	CD	NumType=Card	_	_	_	_
17	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	zymosan	zymosan	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	20	20	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	10	10	NUM	CD	NumType=Card	_	_	_	_
43	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	no	no	DET	DT	_	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 501
# text = Nuclear extracts from LPS- and zymosan-treated cells showed strong AP-1 activity by gel-shift analysis, and supershift analysis showed the AP-1 complexes contained specific members of both the jun and fos gene families.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	zymosan	zymosan	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
26	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	members	member	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	both	both	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
41	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 502
# text = These data indicate that, in contrast to most LPS effects, AP-1, but not nuclear factor-kappaB, mediates LPS induction of collagenase transcription in macrophagelike cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	LPS	Lp	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	macrophagelike	macrophagelike	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 503
# text = Furthermore, as compared to regulation by phorbol ester, collagenase induction in monocytic cells by cell wall derivatives of bacteria or yeast is largely independent of upstream promoter sequences.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
19	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	largely	largely	ADV	RB	_	_	_	_	_
26	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 504
# text = Document 00300244 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300244	00300244	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 505
# text = CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 506
# text = CD30 is a cell-surface receptor that can augment lymphocyte activation and survival through its ability to induce the transcription factor NF-kappaB.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
11	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 507
# text = CD30, however, has also been implicated in the induction of apoptotic cell death of lymphocytes.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 508
# text = Here we show that one of the effects of CD30 signal transduction is to render cells sensitive to apoptosis induced by the type 1 tumor necrosis factor receptor (TNFR1).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	render	render	VERB	VB	VerbForm=Inf	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 509
# text = This sensitization is dependent on the TRAF-binding sites within the CD30 cytoplasmic domain.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 510
# text = One of the proteins that binds to these sites is TRAF2, a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	TNFR1	tNFR1	PROPN	NNP	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 511
# text = During CD30 signal transduction, we found that binding of TRAF2 to the cytoplasmic domain of CD30 results in the rapid depletion of TRAF2 and the associated protein TRAF1 by proteolysis.
1	During	during	ADP	IN	_	_	_	_	_
2	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TRAF2	Traf2	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
18	results	result	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	TRAF1	tRAF1	NUM	CD	NumType=Card	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 512
# text = These data suggest a model in which CD30 limits its own ability to transduce cell survival signals through signal-coupled depletion of TRAF2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
9	limits	limit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	coupled	coupl	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 513
# text = Depletion of intracellular TRAF2 and its coassociated proteins also increased the sensitivity of the cell to undergoing apoptosis during activation of death-inducing receptors such as TNFR1.
1	Depletion	Depletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	coassociated	coassociate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	undergoing	undergoing	ADJ	JJ	Degree=Pos	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 514
# text = Consistent with this hypothesis, expression of a dominant-negative form of TRAF2 was found to potentiate TNFR1-mediated death.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	form	form	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TRAF2	TRAF2	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
19	TNFR1	tNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 515
# text = These studies provide a potential mechanism through which CD30, as well as other TRAF-binding members of the TNFR superfamily, can negatively regulate cell survival.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
22	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	negatively	negatively	ADV	RB	_	_	_	_	_
26	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 516
# text = Document 00300245 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300245	00300245	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 517
# text = Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	AIR	AIR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	during	during	ADP	IN	_	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 518
# text = In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
6	control	control	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 519
# text = Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription.
1	Class	class	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	because	because	ADP	IN	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
14	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
15	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 520
# text = We show here that the plasma cell-specific repressor function, designated SIR (suppressor of immune response genes), does not act directly on the transcription of class II genes, but instead on the transcription of the AIR-1 gene, whose product, the class II transactivator (CIITA), is fundamental for the regulation of the constitutive and inducible expression of MHC class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	SIR	Sir	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
26	directly	directly	ADV	RB	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	instead	instead	ADV	RB	_	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	AIR	Air	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
48	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	class	class	NOUN	NN	Number=Sing	_	_	_	_
52	II	ii	NUM	CD	NumType=Card	_	_	_	_
53	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
59	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
60	for	for	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
68	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
71	class	class	NOUN	NN	Number=Sing	_	_	_	_
72	II	ii	NUM	CD	NumType=Card	_	_	_	_
73	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
74	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 521
# text = This was unambiguously demonstrated by the fact that plasmacytoma x B cell hybrids carrying an AIR-1 locus derived from CIITA-expressing cells do not express CIITA-specific transcripts.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	unambiguously	unambiguously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
10	x	x	SYM	SYM	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
14	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	AIR	AIR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
20	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
29	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 522
# text = Transfection of a cDNA containing the human CIITA coding sequence under the control of an heterologous promoter restores expression of human MHC class II genes in the hybrids and is responsible for de novo expression of mouse MHC class II genes in both the mouse plasmacytoma cell line and the hybrids.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
9	coding	code	NOUN	NN	Number=Sing	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	de	de	PROPN	NNP	Number=Sing	_	_	_	_
34	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
38	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
39	class	class	NOUN	NN	Number=Sing	_	_	_	_
40	II	ii	NUM	CD	NumType=Card	_	_	_	_
41	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	both	both	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
46	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	line	line	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 523
# text = These results confirm and extend the notion of the functional conservation of the AIR-1 gene product across species barriers.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	extend	extend	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AIR	Air	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	product	product	NOUN	NN	Number=Sing	_	_	_	_
19	across	across	ADP	IN	_	_	_	_	_
20	species	species	NOUN	NNS	Number=Plur	_	_	_	_
21	barriers	barrier	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 524
# text = Interestingly, in CIITA-transfected cell hybrids, cell surface expression of the human HLA-DQ heterodimer was not observed.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
19	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 525
# text = This result was not attributable to lack of HLA-DQ alpha or -DQ beta transcription, because both transcripts were present in the CIITA-transfected hybrids, although at reduced levels.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	DQ	Dq	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	although	although	SCONJ	IN	_	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 526
# text = These findings further support our previous observations on the distinct regulation of expression of the human HLA-DQ class II subset, which may be thus controlled at the posttranscriptional level by a CIITA-independent mechanism.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	thus	thus	ADV	RB	_	_	_	_	_
28	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 527
# text = Document 00300246 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300246	00300246	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 528
# text = An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 529
# text = Patients with one type of major histocompatibility complex class II combined immunodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately controls the transcription of the three major human class II genes, HLA-DR, -DQ, and -DP.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	coordinately	coordinately	ADV	RB	_	_	_	_	_
28	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	three	three	NUM	CD	NumType=Card	_	_	_	_
34	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	class	class	NOUN	NN	Number=Sing	_	_	_	_
37	II	ii	NUM	CD	NumType=Card	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 530
# text = However, the experimentally derived B-lymphoblastoid cell line, clone 13, expresses high levels of HLADQ in the absence of HLA-DR and HLA-DP, despite its mapping by complementation analysis to this group.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	experimentally	experimentally	ADV	RB	_	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
13	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HLADQ	HLADq	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	despite	despite	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
37	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
40	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 531
# text = It was possible that one of the clone 13 CIITA alleles bore a mutation that allowed HLA-DQ, but not HLA-DR or -DP transcription.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	bore	bear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DP	Dp	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 532
# text = Alternatively, another factor, distinct from CIITA, might control HLA-DQ expression.
1	Alternatively	Alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	another	another	DET	DT	_	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
12	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 533
# text = We report here that ectopic expression of CIITA cDNAs derived by reverse transcriptase polymerase chain reaction from clone 13 do not restore expression of HLA-DQ in another CIITA-deficient cell line, RJ2.2.5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
9	cDNAs	cDNAs	NOUN	NNS	Number=Plur	_	_	_	_
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
13	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
14	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	_
20	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	another	another	DET	DT	_	_	_	_	_
30	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	RJ	RJ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	2.2.5	2.2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 534
# text = In addition, no CIITA protein is detectable in clone 13 nuclear extracts.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
11	13	13	NUM	CD	NumType=Card	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 535
# text = In contrast, somatic cell fusion between clone 13 and RJ2.2.5 restored expression of the HLA-DQ haplotype encoded by the RJ2.2.5 DQB gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RJ2.2.5	RJ2.2.5	NUM	CD	NumType=Card	_	_	_	_
12	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
19	haplotype	haplotype	NOUN	NN	Number=Sing	_	_	_	_
20	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RJ2.2.5	RJ2.2.5	PROPN	NNP	Number=Sing	_	_	_	_
24	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
25	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 536
# text = Taken together, these data demonstrate the existence of an HLA-DQ isotype-specific trans-acting factor, which functions independently of CIITA.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
14	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	independently	independently	ADV	RB	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 537
# text = Document 00300247 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300247	00300247	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 538
# text = CIITA activates the expression of MHC class II genes in mouse T cells.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 539
# text = It has long been a puzzle that MHC class II molecules are expressed in human T cells after activation but not in mouse T cells; this expression is believed to play a role in the cell mediated immune response.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	long	long	ADV	RB	Degree=Pos	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	puzzle	puzzle	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 540
# text = Recently the MHC class II transactivator (CIITA) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 541
# text = Here we show that human T cells expressing MHC class II have CIITA transcripts while MHC class II-negative human T cells and mouse T cells do not.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	II	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
14	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
17	class	class	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	do	do	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 542
# text = The expression of MHC class II genes in mouse T cells can be reconstituted upon transfection with the human CIITA cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
21	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 543
# text = These data indicate that the expression of CIITA explains the expression or lack of expression of MHC class II in human and mouse T cells respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
9	explains	explain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 544
# text = Document 00300248 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300248	00300248	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 545
# text = Membrane-associated lymphotoxin on natural killer cells activates endothelial cells via an NF-kappaB-dependent pathway.
1	Membrane	membrane	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
7	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 546
# text = BACKGROUND:
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 547
# text = Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
7	models	model	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	xenotransplantation	xenotransplantation	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	graft	graft	NOUN	NN	Number=Sing	_	_	_	_
13	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
16	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 548
# text = We have previously demonstrated that human NK cells activate porcine EC in vitro, which results in adhesion molecule expression and cytokine secretion.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	porcine	porcine	PRON	PRP	_	_	_	_	_
11	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	DET	WDT	PronType=Int	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 549
# text = In this study, we used the NK cell line NK92 to define the molecular and cellular basis of NK cell-mediated EC activation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NK92	Nk92	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 550
# text = METHODS: EC were transfected with either reporter constructs containing the luciferase gene driven either by E-selectin or interleukin (IL)-8 promoters or a synthetic NF-kappaB-dependent promoter.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	either	either	DET	DT	_	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	8	8	NUM	CD	NumType=Card	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 551
# text = In addition, a dominant-negative mutant tumor necrosis factor receptor
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 552
# text = I (TNFRI) expression vector was co-transfected in inhibition studies.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TNFRI	TNFRI	X	AFX	_	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 553
# text = Forty-eight hours after transfection, EC were stimulated with NK cells or NK cell membrane extracts for 7 hr and activation was measured by a luciferase assay.
1	Forty	Forty	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	eight	eight	NUM	CD	NumType=Card	_	_	_	_
4	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
29	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 554
# text = RESULTS: Co-culture of NK cells with transfected EC enhanced E-selectin, IL-8, and NF-kappaB-dependent promoter activity.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Co-culture	Co-culture	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 555
# text = NK cell membrane extracts retained the capacity to activate EC and induced nuclear translocation of NF-kappaB (p50 and p65).
1	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	retained	retain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	p50	p50	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 556
# text = Western blotting of NK cell and membrane extracts detected the presence of Lymphotoxin-alpha (LTalpha) but not tumor necrosis factor-alpha.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Lymphotoxin	Lymphotoxin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LTalpha	LTalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	tumor	tumor	ADP	IN	_	_	_	_	_
22	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 557
# text = Furthermore, LTalpha was secreted in NK:EC co-cultures.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LTalpha	LTalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NK:EC	Nk:ec	PROPN	NNP	Number=Sing	_	_	_	_
8	co-cultures	co-culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 558
# text = Co-transfection with dominant-negative mutant TNFRI inhibited EC activation by NK cell membrane extracts and by NK cells by 80% and 47%, respectively.
1	Co-transfection	Co-transfection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	TNFRI	Tnfri	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 559
# text = The same pattern of inhibition was observed using anti-human LT sera.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
10	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
11	sera	sera	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 560
# text = CONCLUSIONS: Human NK cell membrane-bound LT signals across species via TNFRI, leading to NF-kappaB nuclear translocation and transcription of E-selectin and IL-8, which results in EC activation.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	across	across	ADP	IN	_	_	_	_	_
12	species	species	NOUN	NNS	Number=Plur	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	DET	WDT	PronType=Int	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 561
# text = The discrepancy in the degree of inhibition by membrane extracts and NK cells with mutant TNFRI suggests that additional pathways are utilized by NK cells to activate EC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	discrepancy	discrepancy	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	membrane	membrane	ADJ	JJ	Degree=Pos	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	_
17	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 562
# text = Document 00300249 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300249	00300249	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 563
# text = NF-kappaB only partially mediates Epstein-Barr virus latent membrane protein 1 activation of B cells.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 564
# text = The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is required for EBV-induced immortalization of human B cells and causes tumorigenic transformation of cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
30	tumorigenic	tumorigenic	ADJ	JJ	Degree=Pos	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 565
# text = LMP1 expression induces phenotypic changes resembling B cell activation, such as cell size increase and up-regulation of cell surface activation markers.
1	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	size	size	NOUN	NN	Number=Sing	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 566
# text = LMP1 contains two domains that activate the transcription factor NF-kappaB, one through interactions with TRAF proteins and the other with the TRADD protein.
1	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TRAF	TRAF	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 567
# text = The purpose of the present study was to investigate the importance of NF-kappaB induction in the up-regulation of the B cell activation markers ICAM-1 and CD71 by LMP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
28	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	CD71	CD71	PROPN	NNP	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 568
# text = This study shows that expression of LMP1 activates transcription from p50/p65- and c-Rel- responsive promoters, and that this activity can be completely inhibited by expression of a dominant inhibitory IkappaB mutant.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
8	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	p50/p65-	p50/p65-	PUNCT	:	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	completely	completely	ADV	RB	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
34	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
35	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 569
# text = ICAM-1 and CD71 are nevertheless up-regulated by LMP1 in primary B cells and cell lines expressing the dominant IkappaB.
1	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	CD71	Cd71	PROPN	NNP	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nevertheless	nevertheless	ADV	RB	_	_	_	_	_
8	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 570
# text = Furthermore, LMP1-induced cell size increase of primary B cells was unaffected by IkappaB expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	size	size	NOUN	NN	Number=Sing	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 571
# text = It was concluded that even when LMP1 is unable to activate NF-kappaB, it is still capable of inducing certain characteristics of activated B cells, strongly suggesting that LMP1 can also activate cells independently of NF-kappaB.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	even	even	ADV	RB	_	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	still	still	ADV	RB	_	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
23	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	strongly	strongly	ADV	RB	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	independently	independently	ADV	RB	_	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 572
# text = Document 00300250 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300250	00300250	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 573
# text = Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	bifunctional	bifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 574
# text = Interaction between protein kinase C (PKC)- and glucocorticoid receptor (GR)-mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
27	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
29	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
30	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
38	GR	Gr	ADV	RB	_	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
45	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
46	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
52	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
53	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 575
# text = Here we report that this interference is cell specific, as TPA augmented dexamethasone-induced transcriptional activation of the MMTV LTR in several T cell lines but was inhibitory in NIH-3T3 fibroblasts.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
13	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	NIH	NIH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
35	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 576
# text = TPA-GR synergism was determined to have occurred at the GR-responsive element (GRE) level by functional analysis of deletion mutants or synthetic GRE oligonucleotides driving chloramphenicol acetyl-transferase expression.
1	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
4	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
9	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
22	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
25	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
28	GRE	Gre	NOUN	NN	Number=Sing	_	_	_	_
29	oligonucleotides	oligonucleotide	SCONJ	IN	_	_	_	_	_
30	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
31	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
32	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 577
# text = Synergism required an intact GR DNA-binding domain, whereas amino- or carboxyl-terminal domains were dispensable.
1	Synergism	Synergism	PROPN	NNP	Number=Sing	_	_	_	_
2	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
5	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 578
# text = The effect was abrogated by the PKC inhibitor staurosporine, suggesting a role for PKC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 579
# text = Increased c-jun, jun-B, and jun-D expression above basal levels and increased transcriptional activity of AP-1/TPA responsive elements fused to chloramphenicol acetyl-transferase vectors were observed in T cells treated with TPA alone or in combination with dexamethasone.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-D	-d	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	above	above	ADP	IN	_	_	_	_	_
13	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	chloramphenicol	chloramphenicol	VERB	VB	VerbForm=Inf	_	_	_	_
30	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
33	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
42	alone	alone	ADV	RB	_	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 580
# text = The ability of Jun proteins to cooperate with GR in T cells has been investigated after transfection of c-jun, jun-B, or jun-D expression vectors, which augmented GR-dependent transcription from either MMTV LTR or GRE.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	D	d	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	GR	GR	ADV	RB	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	either	either	CCONJ	CC	_	_	_	_	_
40	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
41	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 581
# text = Conversely, c-jun and jun-B transfection blunted GR-dependent transcription in HeLa cells.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
8	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
9	blunted	blunt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	GR	GR	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 582
# text = The presence of c-fos had a negative influence on GR function and correlated with the cell-specific synergistic or antagonistic activity of Jun with respect to GR; high basal expression of c-fos as well as AP-1 DNA binding and transcriptional activity were observed in HeLa cells, but not in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	well	well	ADV	RB	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
50	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	but	but	CCONJ	CC	_	_	_	_	_
57	not	not	ADV	RB	_	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	T	t	PROPN	NNP	Number=Sing	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 583
# text = Furthermore overexpression of exogenous c-fos has an inhibitory effect on GR-dependent transcription from GRE in T cells.
1	Furthermore	furthermore	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 584
# text = We propose that Jun plays a bifunctional role on GR-dependent transcriptional activation of GRE, selecting either synergistic or antagonistic activity depending on the cell-specific microenvironment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	bifunctional	bifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	selecting	selecte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	either	either	CCONJ	CC	_	_	_	_	_
20	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 585
# text = In this regard, intracellular levels of c-fos appear to be influential.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	influential	influential	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 586
# text = Document 00300251 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300251	00300251	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 587
# text = Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	receptor-	receptor-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	line	line	NOUN	NN	Number=Sing	_	_	_	_
31	EL4	El4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 588
# text = The association and activation of the IL-1 receptor-associated protein kinase (IRAK) to the IL-1 receptor complex is one of the earliest events detectable in IL-1 signal transduction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	association	association	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	one	one	NUM	CD	NumType=Card	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
30	events	event	NOUN	NNS	Number=Plur	_	_	_	_
31	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
37	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 589
# text = We generated permanent clones of the murine T cell line EL4 6.1 overexpressing human (h)IRAK to evaluate the role of this kinase in IL-1 signaling.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	EL4	EL4	NUM	CD	NumType=Card	_	_	_	_
12	6.1	6.1	NUM	CD	NumType=Card	_	_	_	_
13	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 590
# text = Overexpression of hIRAK enhanced IL-1-stimulated activation of the transcription factor NFkappaB, whereas a truncated form (N-IRAK) specifically inhibited IL-1-dependent NFkappaB activity.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hIRAK	hIRAK	PROPN	NNP	Number=Sing	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	form	form	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	specifically	specifically	ADV	RB	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 591
# text = In clones stably overexpressing hIRAK a weak constitutive activation of NFkappaB correlated with a low basal IL-2 production which was enhanced in an IL-1-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
5	hIRAK	hIRAK	PROPN	NNP	Number=Sing	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
16	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 592
# text = Compared to the parental cell line the dose-response curve of IL-1-induced IL-2 production was shifted in both potency and efficacy.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	curve	curve	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	shifted	shift	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 593
# text = These results demonstrate that IRAK directly triggers NFkappaB-mediated gene expression in EL4 cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 594
# text = Qualitatively different effects were observed for the IL-1-induced activation of stress-activated protein (SAP) kinases: permanent overexpression of IRAK did not affect the dose dependence but prolonged the kinetics of IL-1-induced activation of SAP kinases, suggesting that this signaling branch may be regulated by distinct mechanisms.
1	Qualitatively	Qualitatively	ADV	RB	_	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	SAP	sap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
25	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
33	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	prolonged	prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	SAP	sap	NOUN	NN	Number=Sing	_	_	_	_
47	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
50	that	that	SCONJ	IN	_	_	_	_	_
51	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
52	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
53	branch	branch	NOUN	NN	Number=Sing	_	_	_	_
54	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
55	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
56	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
59	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 595
# text = Document 00300252 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300252	00300252	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 596
# text = Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	p105	p105	NUM	CD	NumType=Card	_	_	_	_
4	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transiently	transiently	ADV	RB	_	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 597
# text = Regulation of the transcription factor NF-kappaB involves proteasome-mediated processing of the NF-kappaB1 p105 precursor protein, which generates the p50 subunit of NF-kappaB.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
19	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
20	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
27	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 598
# text = The processing of p105 occurs constitutively in vivo but can be markedly enhanced by various cellular activation agents, although the underlying regulatory mechanism is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p105	p105	NUM	CD	NumType=Card	_	_	_	_
5	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	markedly	markedly	ADV	RB	_	_	_	_	_
13	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	although	although	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	yet	yet	ADV	RB	_	_	_	_	_
28	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 599
# text = In the present study, we demonstrate that signal-mediated induction of p105 processing in human T cells is associated with de novo synthesis of this precursor protein.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p105	p105	NUM	CD	NumType=Card	_	_	_	_
15	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	de	de	NOUN	NN	Number=Sing	_	_	_	_
24	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 600
# text = Transient transfection studies performed in COS7 cells revealed that the newly synthesized p105 protein appears to be more rapidly processed compared to its accumulated form that is already associated with the processed product p50.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	COS7	COS7	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	newly	newly	ADV	RB	_	_	_	_	_
12	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	p105	p105	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	more	more	ADV	RBR	_	_	_	_	_
19	rapidly	rapidly	ADV	RB	_	_	_	_	_
20	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	already	already	ADV	RB	_	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	product	product	NOUN	NN	Number=Sing	_	_	_	_
34	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 601
# text = Interestingly, the processing rate of p105 is markedly inhibited in cells co-transfected with p50 or other NF-kappaB subunits, including RelA and c-Rel, that physically interact with p105.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	physically	physically	ADV	RB	_	_	_	_	_
32	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 602
# text = These findings suggest that the processing of p105 is subject to negative regulation by the various NF-kappaB subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
20	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 603
# text = We further demonstrate that p105 undergoes degradation in lipopolysaccharide-stimulated human monocytic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p105	p105	NUM	CD	NumType=Card	_	_	_	_
6	undergoes	undergo	NOUN	NNS	Number=Plur	_	_	_	_
7	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 604
# text = However, the inducible degradation of p105 is not coupled with the generation of p50.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p105	p105	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 605
# text = Together, these studies demonstrate that the processing and inducible degradation of p105 are differentially regulated.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	differentially	differentially	ADV	RB	_	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 606
# text = Document 00300253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300253	00300253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 607
# text = The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	12-O-	12-o-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 608
# text = Terminal differentiation of the leukemic cell lines U-937 and HL-60 by 12-O-tetradecanoylphorbol-13-acetate is accompanied by marked changes in gene expression.
1	Terminal	Terminal	NOUN	NN	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	U-	U-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	12-O-	12-o-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 609
# text = In this study, we demonstrate that the expression of jun and fos gene family members is induced with variable kinetics during 12-O-tetradecanoylphorbol-13-acetate induced differentiation, with c-jun expression best paralleling differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
21	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
34	paralleling	paralleling	NOUN	NN	Number=Sing	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 610
# text = The generation of AP-1 complexes, as measured by DNA binding activity, closely parallels morphological differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	closely	closely	ADV	RB	_	_	_	_	_
17	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
18	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 611
# text = Furthermore, the ability of these complexes to regulate gene expression is demonstrated by increased transcription from an AP-1 driven reporter construct and marked increases in the expression of endogenous AP-1 regulated genes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 612
# text = Differentiation assays using water soluble phorbol esters reveal that differentiation becomes irreversible soon after AP-1 appears.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	water	water	NOUN	NN	Number=Sing	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
7	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
8	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	_
13	soon	soon	ADV	RB	Degree=Pos	_	_	_	_
14	after	after	SCONJ	IN	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 613
# text = This tight correlation between c-jun expression, the generation of AP-1 activity, and differentiation suggests a critical role for this gene and transcriptional complex during this process.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 614
# text = Document 00300254 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300254	00300254	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 615
# text = Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	PROPN	NNP	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/AP	/ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 616
# text = Two cis-acting elements GM-kappa B/GC-box and CLE0, of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate (PMA) and Ca2+ ionophore (A23187).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B/GC	B/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	gene	gene	PRON	NN	Number=Sing	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
47	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	+	+	SYM	SYM	_	_	_	_	_
54	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 617
# text = The GM-kappa B sequence is recognized by NF-kappa B, which is mainly induced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	gm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mainly	mainly	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 618
# text = The CLE0 sequence interacts with factors, related to a PMA-induced AP-1 and a PMA/A23187-induced NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	PMA/A23187	PMA/A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 619
# text = We examined whether signal transducing components in T cells can activate transcription of the GM-CSF gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 620
# text = Cotransfection of NF-kappa B (p50/p65)- or AP-1 (c-Jun/c-Fos)- expression vectors into Jurkat cells with a luciferase reporter containing the GM-CSF promoter did not stimulate transcription from the GM-CSF promoter.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)-	)-	PUNCT	.	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	Jun/c	Jun/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
30	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
31	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 621
# text = In contrast, cotransfection with a combination of NF-kappa B and AP-1 significantly augmented transcription from the GM-CSF promoter containing the GM-kappa B/GC-box and the CLE0 (AP-1/NF-AT).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B/GC	B/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	box	box	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1/NF	1/nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	AT	At	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 622
# text = Expression of a constitutively active calcineurin (CN), a Ca2+/calmodulin-dependent protein phosphatase, potentiated by two fold the transcriptional activation by NF-kappa B/AP-1.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CN	CN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 623
# text = Both constitutively active forms of CN and protein kinase C (PKC) synergistically activated transcription from the GM-CSF promoter.
1	Both	both	DET	DT	_	_	_	_	_
2	constitutively	constitutively	ADV	RB	_	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	synergistically	synergistically	ADV	RB	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 624
# text = These results suggest that cooperation among NF-kappa B-, AP-1- and NF-AT-binding sequences is required for induction of the GM-CSF gene through PKC- and Ca2+- signaling pathways downstream of T cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
6	among	among	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	AT	at	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
33	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	+-	+-	PUNCT	,	_	_	_	_	_
40	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
41	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
42	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 625
# text = Document 00300255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300255	00300255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 626
# text = Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
8	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
9	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 627
# text = Here, we report the functional expression of CD40 on human malignant melanomas (MMs).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
13	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	MMs	Mms	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 628
# text = Comparison of tumor specimen from MM precursor lesions, primary tumors, and metastases revealed that CD40 surface expression is down-regulated during tumor progression.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	specimen	speciman	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	MM	mm	NUM	CD	NumType=Card	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	_
15	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 629
# text = CD40 expression was confirmed in 7 human MM cell lines established from immunogenic primary tumors or metastases, whereas 11 cell lines established from advanced stages were CD40 negative.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	MM	mm	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	11	11	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
23	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
26	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
29	negative	negative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 630
# text = CD40 expression could be enhanced in CD40-positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering.
1	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	MM	mm	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
19	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
35	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 631
# text = CD40 ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a, and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	MM	mm	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	CD40L	CD40L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	murine	murine	PRON	PRP	_	_	_	_	_
10	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
17	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
32	class	class	NOUN	NN	Number=Sing	_	_	_	_
33	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	class	class	NOUN	NN	Number=Sing	_	_	_	_
36	II	ii	NUM	CD	NumType=Card	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
51	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
58	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
59	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-stimulating	-stimulat	VERB	VBG	VerbForm=Ger	_	_	_	_
61	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
62	and	and	CCONJ	CC	_	_	_	_	_
63	also	also	ADV	RB	_	_	_	_	_
64	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
66	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
67	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
70	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
71	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
72	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
73	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
74	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 632
# text = Furthermore, CD40 ligation of a HLA-A2+, MelanA/MART1+
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	A2+	a2+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	MelanA	MelanA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	MART1	MART1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 633
# text = MM cell line enhanced its susceptibility to specific lysis by a HLA-A2-restricted, MelanA/MART-1-specific CTL clone.
1	MM	mm	NUM	CD	NumType=Card	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	line	line	NOUN	NN	Number=Sing	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	A2	a2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	MelanA/MART	MelanA/MART	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	CTL	Ctl	NOUN	NN	Number=Sing	_	_	_	_
24	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 634
# text = Finally, CD40 ligation induced growth inhibition and apoptosis in MM.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 635
# text = These results indicate that CD40-CD40L interactions may play an important role in augmenting antitumor immunity and inducing apoptosis in some CD40-positive immunogenic human MMs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD40-CD40L	Cd40-cd40l	ADJ	JJ	Degree=Pos	_	_	_	_
6	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
14	antitumor	antitumor	NOUN	NN	Number=Sing	_	_	_	_
15	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	some	some	DET	DT	_	_	_	_	_
21	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
24	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	MMs	MM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 636
# text = Document 00300256 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300256	00300256	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 637
# text = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
4	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	S6	S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
25	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 638
# text = Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	aa565-	aa565-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	647	647	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
21	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
24	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	-10	-10	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 639
# text = The signal cascade transducing this effect is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
4	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	yet	yet	ADV	RB	_	_	_	_	_
10	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 640
# text = In this study, we examined whether gp41-induced IL-10 up-regulation is mediated by the previously described synergistic activation of cAMP and NF-kappaB pathways.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	gp41	gp41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	previously	previously	ADV	RB	_	_	_	_	_
22	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 641
# text = gp41 induced cAMP accumulation in monocytes in a time- and concentration-dependent manner and the adenylate cyclase inhibitor SQ 22536 suppressed gp41-induced IL-10 production in monocytes.
1	gp41	gp41	X	LS	_	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
4	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
19	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	SQ	sq	NOUN	NN	Number=Sing	_	_	_	_
22	22536	22536	NUM	CD	NumType=Card	_	_	_	_
23	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	gp41	gp41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 642
# text = In contrast, gp41 failed to stimulate NF-kappaB binding activity in as much as no NF-kappaB bound to the main NF-kappaB-binding site 2 of the IL-10 promoter after addition of gp41.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
5	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	after	after	ADP	IN	_	_	_	_	_
38	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 643
# text = We also examined the involvement of other signal transduction pathways.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 644
# text = Specific inhibitors of p70(S6)-kinase (rapamycin), and Gi protein (pertussis toxin), prevented induction of IL-10 production by gp41 in monocytes, while inhibitors of the phosphatidylinositol 3-kinase (PI 3-kinase) (wortmannin) and mitogen-activated protein kinase (MAPK) pathway (PD 98059) did not.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	S6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	pertussis	pertussis	NOUN	NN	Number=Sing	_	_	_	_
19	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	10	10	NUM	CD	NumType=Card	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	while	while	SCONJ	IN	_	_	_	_	_
35	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PI	Pi	NUM	CD	NumType=Card	_	_	_	_
44	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
61	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
62	PD	P	NOUN	NN	Number=Sing	_	_	_	_
63	98059	98059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
66	not	not	PART	RB	_	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 645
# text = Thus HIV-1 gp41-induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70(S6)-kinase activation.
1	Thus	thus	PROPN	NNP	Number=Sing	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	rather	rather	ADV	RB	_	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	operate	operate	VERB	VB	VerbForm=Inf	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
39	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	pertussis-	pertussis-	SYM	NFP	_	_	_	_	SpaceAfter=No
42	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
45	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
47	Go	go	PROPN	NNP	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
51	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	S6	S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 646
# text = Document 00300257 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300257	00300257	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 647
# text = Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
11	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 648
# text = Dimerization among transcription factors has become a recurrent theme in the regulation of eukaryotic gene expression.
1	Dimerization	Dimerization	NOUN	NN	Number=Sing	_	_	_	_
2	among	among	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
9	theme	theme	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 649
# text = Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is a homeodomain-containing protein that functions as a dimer.
1	Hepatocyte	Hepatocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 650
# text = A dimerization cofactor of HNF-1 alpha (DCoH) was identified that displayed a restricted tissue distribution and did not bind to DNA, but, rather, selectively stabilized HNF-1 alpha dimers.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
3	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	rather	rather	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	selectively	selectively	ADV	RB	_	_	_	_	_
32	stabilized	stabilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 651
# text = The formation of a stable tetrameric DCoH-HNF-1 alpha complex, which required the dimerization domain of HNF-1 alpha, did not change the DNA binding characteristics of HNF-1 alpha, but enhanced its transcriptional activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
6	tetrameric	tetrameric	NOUN	NN	Number=Sing	_	_	_	_
7	DCoH	DCoH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 652
# text = However, DCoH did not confer transcriptional activation to the GAL4 DNA binding domain.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 653
# text = These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	tetrameric	tetrameric	ADJ	JJ	Degree=Pos	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
19	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 654
# text = Document 00300258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300258	00300258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 655
# text = Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B. (2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid (E3330), is a novel agent with hepatoprotective activity.
1	Inhibitory	Inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	quinone	quinone	NOUN	NN	Number=Sing	_	_	_	_
9	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor-kappa	factor-kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	2E	2E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	3-[	3-[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	5-(	5-(	SYM	NFP	_	_	_	_	SpaceAfter=No
32	2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2	2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	_
34	propenoic	propenoic	ADJ	JJ	Degree=Pos	_	_	_	_
35	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	E3330	E3330	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
43	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	hepatoprotective	hepatoprotective	ADJ	JJ	Degree=Pos	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 656
# text = We report the effect of E3330 on transcriptional activation of tumor necrosis factor (TNF)-alpha gene and on nuclear factor (NF)-kappa B activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	E3330	E3330	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 657
# text = Nuclear run-on experiments showed that E3330 decreases transcriptional activation of TNF-alpha gene induced by lipopolysaccharide (LPS) stimulation in human peripheral monocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
9	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 658
# text = To investigate the inhibitory mechanisms, we constructed a secreted-type placental alkaline phosphatase (PLAP) reporter gene whose transcription is controlled by a 1.4-kb human TNF-alpha promoter.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	constructed	construct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	placental	placental	NOUN	NN	Number=Sing	_	_	_	_
14	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
15	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PLAP	PLAP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	1.4	1.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 659
# text = A stable transformant of the PLAP reporter gene derived from human monocytic cell line showed very little activity on the promoter before stimulation, whereas LPS stimulation led to a dramatic increase in PLAP activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
3	transformant	transformant	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PLAP	PLAP	PROPN	NNP	Number=Sing	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	very	very	ADV	RB	_	_	_	_	_
17	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	before	before	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	PLAP	Plap	NOUN	NN	Number=Sing	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 660
# text = E3330 inhibited this induced promoter activity in a dose-dependent manner.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 661
# text = There are four putative NF-kappa B binding sites (kappa B-1, kappa B-2, kappa B-3, kappa B-4) in human TNF-alpha promoter.
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	four	four	NUM	CD	NumType=Card	_	_	_	_
4	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 662
# text = By using mutated promoter-PLAP plasmids, we established that these NF-kappa B sites were necessary for induction of TNF-alpha transcription on stimulation with LPS.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	PLAP	pLAp	NOUN	NN	Number=Sing	_	_	_	_
7	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 663
# text = A gel retardation experiment with synthetic double-stranded oligonucleotides showed that activated NF-kappa B consisting of p50/p65 heterodimer bound to all four putative NF-kappa B DNA probes, suggesting that all four putative NF-kappa B recognition sites play an important role in inducible TNF-alpha expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
4	experiment	experiment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
24	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	all	all	DET	DT	_	_	_	_	_
27	four	four	NUM	CD	NumType=Card	_	_	_	_
28	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	probes	probe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	all	all	DET	DT	_	_	_	_	_
39	four	four	NUM	CD	NumType=Card	_	_	_	_
40	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
46	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
47	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
50	role	role	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
53	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 664
# text = E3330 decreased activated NF-kappa B in nuclei, suggesting that E3330 inhibits NF-kappa B activation and/or translocation of the nuclei.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
14	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	or	or	CCONJ	CC	_	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 665
# text = Western blotting analysis with anti-I kappa B-alpha antibody indicated that E3330 inhibited degradation of I kappa B-alpha, which is an inhibitory protein of NF-kappa B, in LPS-stimulated monocytes.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blott	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
6	-I	-i	X	AFX	_	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
14	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 666
# text = E3330 may suppress the production of active oxygen species serving as common messengers to activate NF-kappa B.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
9	species	species	NOUN	NNS	Number=Plur	_	_	_	_
10	serving	serve	VERB	VBG	VerbForm=Ger	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 667
# text = Document 00300259 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300259	00300259	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 668
# text = Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632]
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
9	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
28	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Proc	Proc	PROPN	NNP	Number=Sing	_	_	_	_
31	Natl	Natl	PROPN	NNP	Number=Sing	_	_	_	_
32	Acad	Acad	PROPN	NNP	Number=Sing	_	_	_	_
33	Sci	sci	PROPN	NNP	Number=Sing	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	_
35	S	be	PART	POS	_	_	_	_	_
36	A	a	PROPN	NNP	Number=Sing	_	_	_	_
37	1995	1995	NUM	CD	NumType=Card	_	_	_	_
38	Apr	Apr	PROPN	NNP	Number=Sing	_	_	_	_
39	11;92	11;92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	8):3632	8):3632	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 669
# text = The host response to Mycobacterium tuberculosis includes granuloma formation at sites of infection and systemic symptoms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	host	host	NOUN	NN	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
6	tuberculosis	tuberculosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	granuloma	granuloma	NOUN	NN	Number=Sing	_	_	_	_
9	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 670
# text = Cytokines have been identified by immunohistochemistry in granulomas in animal models of bacillus Calmette-Guerin (BCG) infection and are released by mononuclear phagocytes upon stimulation by mycobacterial proteins.
1	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	granulomas	granuloma	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
11	models	model	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	bacillus	bacillus	ADJ	JJ	Degree=Pos	_	_	_	_
14	Calmette	Calmette	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Guerin	Guerin	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	BCG	BCG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	upon	upon	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 671
# text = In this regard, the cytokine interleukin 6 (IL-6) may play a role in the clinical manifestations and pathological events of tuberculosis infection.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
21	manifestations	manifestation	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	tuberculosis	tuberculosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 672
# text = We have demonstrated that lipoarabinomannan (LAM) from the mycobacterial cell wall, which was virtually devoid of lipopolysaccharide (LPS), stimulated mononuclear phagocytes to release IL-6 in a dose-response manner.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LAM	LAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	wall	wall	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	virtually	virtually	ADV	RB	_	_	_	_	_
18	devoid	devoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 673
# text = LAM and LPS were potent inducers of IL-6 gene expression in peripheral blood monocytes.
1	LAM	LAM	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
6	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 674
# text = Both LAM- and LPS-inducible IL-6 promoter activity was localized to a DNA fragment, positions -158 to -49, by deletion analysis and chloramphenicol acetyltransferase assay.
1	Both	both	DET	DT	_	_	_	_	_
2	LAM	LAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	158	158	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	49	49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
29	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
32	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
33	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 675
# text = Two nuclear factor NF-IL6 (positions -153 to -145 and -83 to -75) and one nuclear factor NF-kappa B (positions -72 to -63) motifs are present within this fragment.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	153	153	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	145	145	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	83	83	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	72	72	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
40	within	within	ADP	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 676
# text = Site-directed mutagenesis of one or more of these motifs within the IL-6 promoter demonstrated that each has positive regulatory activity and that they could act in a function- and orientation-independent manner.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	each	each	DET	DT	_	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 677
# text = Deletion of all three elements abolished inducibility of IL-6 promoter activity by both LAM and LPS.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	LAM	LAm	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 678
# text = We conclude that the NF-IL6 and NF-kappa B sites mediate IL-6 induction in response to both LPS and LAM, acting as bacterial or mycobacterial response elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	LAM	LAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 679
# text = Document 00300260 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300260	00300260	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 680
# text = The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
8	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	TAFII32	Tafii32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 681
# text = The class II trans- activator (CIITA) is the main transcriptional co-activator for the expression of MHC class II proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	co-activator	co-activator	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 682
# text = Its N-terminal 125 amino acids function as an independent transcriptional activation domain.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	125	125	NUM	CD	NumType=Card	_	_	_	_
5	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
6	acids	acids	NOUN	NNS	Number=Plur	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 683
# text = Analyses of the primary amino acid sequence of the activation domain predict the presence of three alpha-helices, each with a high proportion of acidic residues.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	amino	amino	X	GW	_	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	predict	predict	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	helices	helice	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	each	each	DET	DT	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
25	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
28	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 684
# text = Using site-directed mutagenesis, we found that two of these predicted alpha-helices are required for full transcriptional activation by CIITA.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	helices	helice	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 685
# text = Moreover, a CIITA protein in which both functional alpha-helices have been deleted displays a dominant negative phenotype.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	helices	helice	NOUN	NNS	Number=Plur	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 686
# text = This activation domain of CIITA interacts with the 32 kDa subunit of the general transcription complex TFIID, TAFII32.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	32	32	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	TAFII32	TAFII32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 687
# text = Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	directly	directly	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	TAFII32	Tafii32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 688
# text = We conclude that interactions between TAFII32 and CIITA are responsible for activation of class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	TAFII32	Tafii32	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 689
# text = Document 00300261 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300261	00300261	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 690
# text = Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 691
# text = Convergence of costimulatory signals and differences from transformed T cells.
1	Convergence	Convergence	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 692
# text = To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	optimized	optimize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 693
# text = Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
14	closely	closely	ADV	RB	_	_	_	_	_
15	parallels	parallel	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 694
# text = As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.
1	As	as	SCONJ	IN	_	_	_	_	_
2	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mutagenized	mutagenize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	most	most	ADV	RBS	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 695
# text = Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.
1	Both	both	DET	DT	_	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
20	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
44	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 696
# text = Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	much	much	ADV	RB	_	_	_	_	_
13	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 697
# text = We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
24	converge	converge	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
28	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 698
# text = Document 00300262 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300262	00300262	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 699
# text = Interleukin 10 induced c-fos expression in human B cells by activation of divergent protein kinases.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	10	10	NUM	CD	NumType=Card	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 700
# text = IL-10 is a potent mediator of human B cell growth and plasma cell formation.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 701
# text = However, signal transduction of IL-10 in B cells is poorly understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	poorly	poorly	ADV	RB	_	_	_	_	_
14	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 702
# text = In this study the effect of IL-10 on the expression of the protooncogene c-fos was investigated, because Fos plays a potential role in the regulation of B cell proliferation and differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	because	because	SCONJ	IN	_	_	_	_	_
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
23	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 703
# text = B cells were purified from buffy coat preparations of healthy blood donors by positive selection using an anti CD20 monoclonal antibody and a MiniMACS separation unit.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	buffy	buffy	NOUN	NN	Number=Sing	_	_	_	_
7	coat	coat	NOUN	NN	Number=Sing	_	_	_	_
8	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	anti	anti	X	AFX	_	_	_	_	_
19	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
20	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
21	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	MiniMACS	MiniMACS	PROPN	NNP	Number=Sing	_	_	_	_
25	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
26	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 704
# text = B cells were prestimulated with SAC for 48 hrs.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	prestimulated	prestimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	SAC	Sac	PROPN	NNP	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	48	48	NUM	CD	NumType=Card	_	_	_	_
9	hrs	hr	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 705
# text = Then, cells were incubated with medium or IL-10 (100 ng/ml) for 10 to 120 min.
1	Then	then	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IL-10	IL-10	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	100	100	NUM	CD	NumType=Card	_	_	_	_
12	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	120	120	NUM	CD	NumType=Card	_	_	_	_
19	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 706
# text = RNA was extracted by phenol/chloroform and c-fos expression was analyzed by PCR assisted mRNA assay.
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	chloroform	chloroform	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
17	assisted	assist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 707
# text = A significant 2-4 fold increase of c-fos expression was observed within 30 min of stimulation with IL-10 (p < 0.01).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	30	30	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	10	10	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	p	p	NOUN	NN	Number=Sing	_	_	_	_
26	<	<	PUNCT	-LRB-	_	_	_	_	_
27	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 708
# text = After 2 hrs c-fos expression declined to basal levels.
1	After	after	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	hrs	hr	NOUN	NNS	Number=Plur	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 709
# text = The effect of IL-10 was dose-dependent with a maximum stimulation using 100 ng/ml of IL-10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	100	100	NUM	CD	NumType=Card	_	_	_	_
17	ng/ml	ng/ml	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 710
# text = The IL-10 effect on c-fos expression was not blocked by polymyxin B. Using the tyrosine kinase inhibitor genistein (10 microM) a complete inhibition of IL-10 induced c-fos expression was observed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	polymyxin	polymyxin	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	10	10	NUM	CD	NumType=Card	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 711
# text = In addition, H-7 (10 microM), a specific inhibitor of serine/threonine kinases, significantly blocked IL-10 mediated c-fos expression (p < 0.05).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	p	p	NOUN	NN	Number=Sing	_	_	_	_
33	<	<	PUNCT	-LRB-	_	_	_	_	_
34	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 712
# text = In conclusion, these data show that IL-10 induces c-fos expression in human B-cells by activation of tyrosine and serine/threonine kinases.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
27	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 713
# text = Since this is the first report on IL-10 induced signal transduction, these data may help to identify the intracellular mechanisms by which IL-10 stimulates human B-cells.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	report	report	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	data	data	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 714
# text = Document 00300263 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300263	00300263	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 715
# text = GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells.
1	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	share	share	NOUN	NN	Number=Sing	_	_	_	_
9	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	costimulatory	costimulatory	VERB	VB	VerbForm=Inf	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 716
# text = Antigen complexed with major histocompatibility complex class I or II molecules on the surface of antigen presenting cells interacts with the T cell receptor (TCR) on the surface of T cells and initiates an activation cascade.
1	Antigen	Antigen	PROPN	NNP	Number=Sing	_	_	_	_
2	complexed	complex	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	presenting	presenting	VERB	VBG	VerbForm=Ger	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 717
# text = So called costimulatory signals, mediated by other cell surface interactions or soluble cytokines produced by antigen presenting cells, are also required for complete T cell activation.
1	So	so	ADV	RB	_	_	_	_	_
2	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
18	presenting	presenting	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 718
# text = High levels of cytokine gene expression in T cells also required both TCR and costimulatory signals.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 719
# text = The granulocyte-macrophage colony-stimulating factor requires sequences in the promoter as well as a powerful enhancer located 3kb upstream to respond to TCR-like signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
23	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	like	like	ADP	IN	_	_	_	_	_
30	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 720
# text = These promoter and enhancer regions are mainly activated by the transcription factor nuclear factor of activated T cells (NFAT).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mainly	mainly	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 721
# text = The activation of NFAT by TCR signals has been well described for interleukin-2 (IL-2) and IL-4 gene transcription in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 722
# text = Costimulatory signals, such as activation of the CD28 cell surface molecule on T cells, lead to activation through a distinct region of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter.
1	Costimulatory	Costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
2	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	lead	lead	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
29	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 723
# text = This region is termed the CK-1 or CD28RE and appears to bind specific members of the NF-kappa B family of transcription factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 724
# text = Human T leukemia virus type 1 (HTLV-1) infects T cells and can lead to increase GM-CSF expression.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 725
# text = We have found that the HTLV-1 transactivator protein, tax, acts as a costimulatory signal for GM-CSF and IL-2 gene transcription, in that it can cooperate with TCR signals to mediate high level gene expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	SCONJ	IN	_	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
40	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
41	level	level	NOUN	NN	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 726
# text = Tax activates the GM-CSF promoter through the CK-1/CD28RE region and also activates nuclear factor-kappa B binding to this region.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1/CD28RE	1/CD28RE	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 727
# text = However, other transcription factors or coactivators of NF-kappa B are required for tax activation but these remain to be identified.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	coactivators	coactivator	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 728
# text = The CK-1/CD28RE of GM-CSF shows a high degree of similarity to the IL-2 CD28RE and the IL-3 gene also contains a related region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1/CD28RE	1/CD28RE	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	also	also	ADV	RB	_	_	_	_	_
28	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 729
# text = This observation, together with the fact that both GM-CSF and IL-2 respond to TCR signals via NFAT, implies a high degree of conservation in the regulation of cytokine gene expression in T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	together	together	ADV	RB	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	TCR	TCR	VERB	VB	VerbForm=Inf	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 730
# text = Document 00300264 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300264	00300264	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 731
# text = IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	reconstitutes	reconstitute	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 732
# text = The mechanism by which early lymphoid cells are selectively transformed by v-Abl is currently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	currently	currently	ADV	RB	_	_	_	_	_
17	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 733
# text = Previous studies have shown constitutive activation of IL-4 and IL-7 signaling pathways, as measured by activation of Janus protein kinase (JAK)1, JAK3, STAT5, and STAT6, in pre-B cells transformed by v-Abl.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	7	7	NUM	CD	NumType=Card	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
40	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 734
# text = To determine whether activation of these cytokine signaling pathways by v-Abl is important in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and IL-7 on pre-B cells transformed with a temperature-sensitive v-Abl mutant were examined.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	events	event	NOUN	NNS	Number=Plur	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Abelson	Abelson	PROPN	NNP	Number=Sing	_	_	_	_
24	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	7	7	NUM	CD	NumType=Card	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
40	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
48	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
50	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
51	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 735
# text = Whereas IL-4 had little or no effect, IL-7 delayed both the apoptosis and cell cycle arrest that occur upon v-Abl kinase inactivation.
1	Whereas	whereas	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	7	7	NUM	CD	NumType=Card	_	_	_	_
14	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
21	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 736
# text = IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	delayed	delay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	xL	xL	AUX	MD	VerbForm=Fin	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 737
# text = IL-7 did not maintain v-Abl-mediated differentiation arrest of the pre-B cells, as activation of NF-kappaB and RAG gene transcription was unaffected by IL-7.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
7	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
16	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 738
# text = These results identify a potential role for IL-7 signaling pathways in transformation by v-Abl while demonstrating that a combination of IL-4 and IL-7 signaling cannot substitute for an active v-Abl kinase in transformed pre-B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
34	not	not	PART	RB	_	_	_	_	_
35	substitute	substitute	VERB	VB	VerbForm=Inf	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
39	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
42	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
46	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 739
# text = Document 00300265 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300265	00300265	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 740
# text = Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 741
# text = Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 742
# text = The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocalization	translocalization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 743
# text = However, the HTLV-I genes including Tax are not expressed significantly in primary leukemic cells from ATL patients.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 744
# text = In this study, we examined the basis for NF-kappaB activation in freshly isolated leukemic cells from ATL patients.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	freshly	freshly	ADV	RB	_	_	_	_	_
16	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 745
# text = We found that leukemic cells from ATL patients, like HTLV-I-infected T-cell lines, display constitutive NF-kappaB DNA binding activity and increased degradation of IkappaBalpha (an inhibitor of NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	ATL	ATL	ADJ	JJ	Degree=Pos	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	like	like	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I-	I-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	display	display	NOUN	NN	Number=Sing	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 746
# text = Whereas the NF-kappaB binding activity in Tax-expressing T-cell lines consisted mostly of p50/c-Rel, fresh ATL samples contained p50/p50 and p50/p65 heterodimers.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mostly	mostly	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
23	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
24	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
25	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	p50/p50	p50/p50	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
30	p65	p65	NUM	CD	NumType=Card	_	_	_	_
31	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 747
# text = One T-cell line derived from ATL leukemic cells, TL-Om1, displayed constitutive NF-kappaB activity, as well as enhanced degradation of IkappaBalpha, despite the lack of detectable Tax expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
8	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TL	TL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Om1	Om1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	despite	despite	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
35	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 748
# text = Interestingly, the NF-kappaB in TL-Om1 consists of p50/p50 and p50/p65 like that in fresh primary leukemic cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	TL	TL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Om1	Om1	NUM	CD	NumType=Card	_	_	_	_
11	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50/	p50/	SYM	NFP	_	_	_	_	SpaceAfter=No
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
18	p65	p65	NUM	CD	NumType=Card	_	_	_	_
19	like	like	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
23	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 749
# text = Our results suggest that activation of NF-kappaB occurs through a Tax-independent mechanism in leukemic cells of ATL patients, possibly due to differential NF-kappaB subunit activation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	possibly	possibly	ADV	RB	_	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 750
# text = Document 00300266 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300266	00300266	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 751
# text = Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.
1	Ligand	Ligand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	estrogen	estrogen	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 752
# text = High-dose estrogen administration induces anemia in mammals.
1	High	high	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	dose	dose	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
5	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	anemia	anemion	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mammals	mammal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 753
# text = In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation.
1	In	in	ADP	IN	_	_	_	_	_
2	chickens	chicken	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
5	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	outgrowth	outgrowth	ADP	IN	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
9	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	delay	delay	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 754
# text = This delay is associated with down-regulation of many erythroid cell-specific genes, including alpha- and beta-globin, band 3, band 4.1, and the erythroid cell-specific histone
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	delay	delay	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	band	band	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	band	band	NOUN	NN	Number=Sing	_	_	_	_
29	4.1	4.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 755
# text = H5.
1	H5	h5	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 756
# text = We show here that estrogens also reduce the number of erythroid progenitor cells in primary human bone marrow cultures.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	reduce	reduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	number	number	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
18	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
19	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 757
# text = To address potential mechanisms by which estrogens suppress erythropoiesis, we have examined their effects on GATA-1, an erythroid transcription factor that participates in the regulation of the majority of erythroid cell-specific genes and is necessary for full maturation of erythrocytes.
1	To	to	PART	TO	_	_	_	_	_
2	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
3	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	estrogens	estrogen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
9	erythropoiesis	erythropoiesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
44	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 758
# text = We demonstrate that the transcriptional activity of GATA-1 is strongly repressed by the estrogen receptor (ER) in a ligand-dependent manner and that this repression is reversible in the presence of 4-hydroxytamoxifen.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	estrogen	estrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	hydroxytamoxifen	hydroxytamoxifen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 759
# text = ER-mediated repression of GATA-1 activity occurs on an artificial promoter containing a single GATA-binding site, as well as in the context of an intact promoter which is normally regulated by GATA-1.
1	ER-	ER-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
17	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	context	context	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	normally	normally	ADV	RB	_	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 760
# text = GATA-1 and ER bind to each other in vitro in the absence of DNA.
1	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	ER	er	NOUN	NN	Number=Sing	_	_	_	_
6	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 761
# text = In coimmunoprecipitation experiments using transfected COS cells, GATA-1 and ER associate in a ligand-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	coimmunoprecipitation	coimmunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	COS	Cos	NOUN	NNS	Number=Plur	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ER	er	NOUN	NN	Number=Sing	_	_	_	_
14	associate	associate	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 762
# text = Mapping experiments indicate that GATA-1 and the ER form at least two contacts, which involve the finger region and the N-terminal activation domain of GATA-1.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ER	er	NOUN	NN	Number=Sing	_	_	_	_
11	form	form	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	contacts	contact	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 763
# text = We speculate that estrogens exert effects on erythropoiesis by modulating GATA-1 activity through protein-protein interaction with the ER. (ABSTRACT TRUNCATED AT 250 WORDS)
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
5	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	erythropoiesis	erythropoiesis	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ABSTRACT	Abstract	ADV	RB	_	_	_	_	_
25	TRUNCATED	tRUNCATEd	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
26	AT	at	ADV	RB	_	_	_	_	_
27	250	250	NUM	CD	NumType=Card	_	_	_	_
28	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 764
# text = Document 00300267 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300267	00300267	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 765
# text = HMG-I binds to GATA motifs: implications for an HPFH syndrome.
1	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	HPFH	Hpfh	ADJ	JJ	Degree=Pos	_	_	_	_
13	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 766
# text = We have examined binding of the nuclear protein HMG-I to the human gamma-globin promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 767
# text = We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter; this paired motif is bound by the erythroid factor GATA-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HMG	Hmg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	preferentially	preferentially	ADV	RB	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	paired	paired	ADJ	JJ	Degree=Pos	_	_	_	_
29	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 768
# text = A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells (HPFH) and up-regulation of the gamma-globin promoter in in vitro expression assays; HMG-I does not bind to this mutant sequence.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	naturally	naturally	ADV	RB	_	_	_	_	_
3	occurring	occurre	ADJ	JJ	Degree=Pos	_	_	_	_
4	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
5	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
6	175	175	NUM	CD	NumType=Card	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	area	area	NOUN	NN	Number=Sing	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
28	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
29	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	HPFH	HPFH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	;	;	PUNCT	,	_	_	_	_	_
50	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
52	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
53	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	not	not	PART	RB	_	_	_	_	_
55	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
58	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
59	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 769
# text = A survey of GATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	survey	survey	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
5	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	HMG	Hmg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 770
# text = These findings implicate HMG-I in the HPFH phenotype; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
4	HMG	Hmg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HPFH	Hpfh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	multiprotein	multiprotein	ADJ	JJ	Degree=Pos	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 771
# text = Document 00300268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300268	00300268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 772
# text = A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nongenomic	nongenomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 773
# text = The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
7	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	remained	remain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	elusive	elusive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 774
# text = Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and reversibly blocks voltage-gated and calcium-activated K+ channels (KV and KCa, respectively), resulting in depolarization of the membrane potential.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	placenta	placenta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	rapidly	rapidly	ADV	RB	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	reversibly	reversibly	ADV	RB	_	_	_	_	_
25	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
26	voltage	voltage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gated	gate	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	calcium-	calcium-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	depolarization	depolarization	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
49	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 775
# text = As a result, Ca2+ signaling and nuclear factor of activated T cells (NF-AT)-driven gene expression are inhibited.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 776
# text = Progesterone acts distally to the initial steps of T cell receptor (TCR)-mediated signal transduction, since it blocks sustained Ca2+ signals after thapsigargin stimulation, as well as oscillatory Ca2+ signals, but not the Ca2+ transient after TCR stimulation.
1	Progesterone	Progesterone	PRON	NN	Number=Sing	_	_	_	_
2	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	distally	distally	ADV	RB	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
7	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	since	since	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
23	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ca2	ca2	PART	TO	Abbr=Yes	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	thapsigargin	thapsigargin	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	as	as	ADV	RB	_	_	_	_	_
32	well	well	ADV	RB	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	oscillatory	oscillatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	+	+	SYM	SYM	_	_	_	_	_
44	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
45	after	after	ADP	IN	_	_	_	_	_
46	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
47	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 777
# text = K+
1	K	K	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 778
# text = channel blockade by progesterone is specific; other steroid hormones had little or no effect, although the progesterone antagonist RU 486 also blocked KV and KCa channels.
1	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
2	blockade	blockake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	;	;	PUNCT	,	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
20	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
21	RU	Ru	PROPN	NNP	Number=Sing	_	_	_	_
22	486	486	NUM	CD	NumType=Card	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	_
28	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 779
# text = Progesterone effectively blocked a broad spectrum of K+ channels, reducing both Kv1.3 and charybdotoxin-resistant components of KV current and KCa current in T cells, as well as blocking several cloned KV channels expressed in cell lines.
1	Progesterone	Progesterone	PROPN	NNP	Number=Sing	_	_	_	_
2	effectively	effectively	ADV	RB	_	_	_	_	_
3	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
6	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	Kv1.3	Kv1.3	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	charybdotoxin	charybdotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
19	components	component	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
22	current	current	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	_
25	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	cloned	clon	ADJ	JJ	Degree=Pos	_	_	_	_
36	KV	Kv	PROPN	NNP	Number=Sing	_	_	_	_
37	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 780
# text = Progesterone had little or no effect on a cloned voltage-gated Na+ channel, an inward rectifier K+ channel, or on lymphocyte Ca2+ and Cl- channels.
1	Progesterone	Progesterone	PRON	NN	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	voltage	voltage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gated	gate	ADJ	JJ	Degree=Pos	_	_	_	_
13	Na	na	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	channel	channel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inward	inward	ADJ	JJ	Degree=Pos	_	_	_	_
19	rectifier	rectifier	NOUN	NN	Number=Sing	_	_	_	_
20	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	channel	channel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	+	+	SYM	SYM	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Cl	Cl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 781
# text = We propose that direct inhibition of K+ channels in T cells by progesterone contributes to progesterone-induced immunosuppression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
15	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	progesterone	progesterone	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 782
# text = Document 00300269 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300269	00300269	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 783
# text = Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 784
# text = CD28 is an important costimulatory molecule in the activation of human T cells.
1	CD28	Cd28	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 785
# text = Costimulation of T cells through both the Ag receptor and CD28 leads to high level IL-2 production, which is vital to the development of an immune response in vivo.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	vital	vital	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 786
# text = Previous reports have suggested the CD28 stimulation contributes to the activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including AP-1 and nuclear factor-kappaB (NF-kappaB)/Rel family members as well as an uncharacterized transcription factor called CD28 response complex.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	members	member	NOUN	NNS	Number=Plur	_	_	_	_
46	as	as	ADV	RB	_	_	_	_	_
47	well	well	ADV	RB	Degree=Pos	_	_	_	_
48	as	as	ADP	IN	_	_	_	_	_
49	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	uncharacterized	uncharacterized	ADJ	JJ	Degree=Pos	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
53	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
55	response	response	NOUN	NN	Number=Sing	_	_	_	_
56	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 787
# text = While several lines of investigation have suggested that NF-kappaB/Rel family members make up the CD28 response complex transcription factor, other work has not supported this conclusion.
1	While	while	SCONJ	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	members	member	NOUN	NNS	Number=Plur	_	_	_	_
16	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	up	up	ADP	RP	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NUM	CD	NumType=Card	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	work	work	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 788
# text = Recent studies suggest that the CD28 response element (CD28RE) does not function independently but works instead in conjunction with the adjacent promoter proximal AP-1-binding site and this hypothesis is confirmed here.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
15	independently	independently	ADV	RB	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	works	work	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	instead	instead	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 789
# text = Also in the current study, binding activity to the CD28RE/AP-1 sequence of the IL-2 promoter is evaluated.
1	Also	also	ADV	RB	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 790
# text = Although four specific complexes can be detected binding to this sequence, only one of these complexes is specific for both the CD28RE and the adjacent AP-1 site.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	four	four	NUM	CD	NumType=Card	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 791
# text = Of the NF-kappaB/Rel family members tested, this CD28RE/AP-1-specific complex contains predominantly c-Rel, despite the fact that both p50 and RelA can efficiently bind to the CD28RE.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	predominantly	predominantly	ADV	RB	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	despite	despite	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	efficiently	efficiently	ADV	RB	_	_	_	_	_
36	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 792
# text = c-Fos and c-Jun are also found in this CD28RE/AP-1-specific complex.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 793
# text = These data indicate that functional complexes encompassing both the CD28RE and the AP-1-binding sites influence IL-2 promoter activity in CD28-costimulated T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
7	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 794
# text = Document 00300270 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300270	00300270	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 795
# text = Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion.
1	Monocyte	Monocyte	PROPN	NNP	Number=Sing	_	_	_	_
2	tethering	tether	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
8	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 796
# text = Signal integration and NF-kappa B translocation [see comments]
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 797
# text = Adhesion molecules that tether circulating leukocytes to endothelial cells may also transduce or modulate outside-in signals for cellular activation, providing an initial regulatory point in the inflammatory response.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	tether	tether	SCONJ	IN	_	_	_	_	_
5	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
15	outside	outside	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	in	in	ADP	IN	_	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	point	point	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 798
# text = Adhesion of human monocytes to P-selectin, the most rapidly expressed endothelial tethering factor, increased the secretion of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) by the leukocytes when they were stimulated with platelet-activating factor.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	most	most	ADV	RBS	_	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	tethering	tethering	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
22	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
33	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
44	when	when	ADV	WRB	PronType=Int	_	_	_	_
45	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
46	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 799
# text = Increased cytokine secretion was specifically inhibited by G1, an anti-P-selectin mAb that prevents P-selectin from binding to its ligand (P-selectin glycoprotein ligand-1) on myeloid cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cytokine	cytokine	PRON	PRP	_	_	_	_	_
3	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	anti-P-	anti-P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	SCONJ	IN	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
26	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	X	LS	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 800
# text = Moreover, tethering by P-selectin specifically enhanced nuclear translocation of nuclear factor-kappa B (NF-kappa B), a transcription factor required for expression of MCP-1, TNF-alpha, and other immediate-early genes.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tethering	tether	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
44	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 801
# text = These results demonstrate that P-selectin, through its ligands on monocytes, may locally regulate cytokine secretion in inflamed tissues.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	locally	locally	ADV	RB	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 802
# text = Document 00300271 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300271	00300271	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 803
# text = Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
11	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
12	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
15	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 804
# text = Studies have demonstrated abnormalities of the CD3/T-cell antigen receptor (TCR) and pathways of signal transduction in T lymphocytes from animals and patients with advanced malignancy.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CD3/T-	Cd3/t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
28	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 805
# text = Diminished expression of TCRzeta and p56(lck) that are associated with the TCR and reduced nuclear localization of RelA containing nuclear factor kappaB (NFkappaB) complexes have been noted.
1	Diminished	Diminished	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 806
# text = These defects have been described in T cells from patients with malignant melanoma, renal cell carcinoma (RCC), ovarian cancer, and colorectal cancer.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
13	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	ovarian	ovarian	ADJ	JJ	Degree=Pos	_	_	_	_
23	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	colorectal	colorectal	ADJ	JJ	Degree=Pos	_	_	_	_
27	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 807
# text = Preliminary observations also indicate possible correlation with clinical variables such as stage in selected instances.
1	Preliminary	Preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	selected	selected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	instances	instance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 808
# text = To further characterize altered expression of TCRzeta, p56(lck), and impaired activation of NFkappaB, T lymphocytes were obtained from 65 patients with RCC, the majority of whom were receiving combination cytokine therapy [interleukin (IL)-2, IFN alpha-containing regimens] and 37 control individuals.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	65	65	NUM	CD	NumType=Card	_	_	_	_
26	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	whom	whom	PRON	WP	PronType=Rel	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
36	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
37	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
38	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
39	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	IFN	Ifn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
51	regimens	regimen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	]	]	PUNCT	-RRB-	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	37	37	NUM	CD	NumType=Card	_	_	_	_
55	control	control	NOUN	NN	Number=Sing	_	_	_	_
56	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 809
# text = In 29 of these patients, levels of TCRzeta and p56(lck) were determined by Western blots of T-cell lysates and semiquantitated using densitometry.
1	In	in	ADP	IN	_	_	_	_	_
2	29	29	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
19	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	semiquantitated	semiquantitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
27	densitometry	densitometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 810
# text = Relative levels were then correlated with a series of clinical variables including response to therapy, performance status, survival, disease sites, age, and others.
1	Relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	series	series	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	performance	performance	NOUN	NN	Number=Sing	_	_	_	_
18	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 811
# text = In another group of 28 patients (three individuals from the first group), the frequency of abnormal NFkappaB activation was studied using electrophoretic mobility shift assays after activation of T cells with phorbol myristate acetate/ionomycin or anti-CD3 monoclonal antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	another	another	DET	DT	_	_	_	_	_
3	group	group	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	28	28	NUM	CD	NumType=Card	_	_	_	_
6	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
20	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
36	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
37	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
42	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
43	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 812
# text = Changes in these signaling molecules during cytokine treatment were also investigated.
1	Changes	change	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 813
# text = TCRzeta and p56(lck) were detected in the peripheral blood T cells in 27 of 29 patients, and overall, reduced levels were noted visually in 12 of 29 (41%) and 13 of 29 (45%) individuals, respectively.
1	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	T	t	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	27	27	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	29	29	NUM	CD	NumType=Card	_	_	_	_
19	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	visually	visually	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	12	12	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	29	29	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	13	13	NUM	CD	NumType=Card	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	29	29	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 814
# text = When levels were semiquantitated using densitometry, significant decreases of TCRzeta (P = 0.029) and p56(lck) (P = 0.029) but not CD3epsilon (P = 0.131), compared with control levels, were found.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	semiquantitated	semiquantitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	densitometry	densitometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	P	P	SYM	NFP	_	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	0.029	0.029	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	P	p	NOUN	NN	Number=Sing	_	_	_	_
24	=	=	SYM	SYM	_	_	_	_	_
25	0.029	0.029	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	CD3epsilon	CD3epsilon	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	P	P	SYM	NFP	_	_	_	_	_
32	=	=	SYM	SYM	_	_	_	_	_
33	0.131	0.131	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	control	control	NOUN	NN	Number=Sing	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 815
# text = In patients treated with IL-2/IFN alpha-based therapy, relative levels of TCRzeta increased significantly (P = 0.002) on day 15 of cycle one compared with the baseline.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
3	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	significantly	significantly	ADV	RB	_	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	SYM	NFP	_	_	_	_	_
23	=	=	SYM	SYM	_	_	_	_	_
24	0.002	0.002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	day	day	NOUN	NN	Number=Sing	_	_	_	_
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 816
# text = Correlations of TCRzeta or p56(lck) levels with response or disease variables, except for lower TCRzeta levels (P < 0.001) in the presence of bone metastases, were not found.
1	Correlations	Correlation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
14	variables	variable	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	except	except	ADP	IN	_	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	_
23	<	<	PUNCT	-LRB-	_	_	_	_	_
24	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
31	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 817
# text = Abnormal NFkappaB activation after stimulation with phorbol myristate acetate/ionomycin and/or anti-CD3 monoclonal antibody was found in 59% of patients (17 of 28) and was not accounted for by the advanced age of the study cohort.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/ionomycin	/ionomycin	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	or	or	CCONJ	CC	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	17	17	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	28	28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
37	age	age	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	study	study	NOUN	NN	Number=Sing	_	_	_	_
41	cohort	cohort	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 818
# text = Activation of NFkappaB in peripheral blood T cells was inducible during cytokine therapy in four of six individuals who displayed impaired NFkappaB activity prior to therapy.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	four	four	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	six	six	NUM	CD	NumType=Card	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	who	who	PRON	WP	PronType=Rel	_	_	_	_
20	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
22	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 819
# text = Moreover, impaired activation of NFkappaB does not appear linked to a reduction of TCRzeta expression, because in five patients, normal TCRzeta levels were present although kappaB binding was not inducible.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	five	five	NUM	CD	NumType=Card	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	although	although	SCONJ	IN	_	_	_	_	_
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 820
# text = In the majority of patients with advanced RCC, peripheral blood T cells express TCRzeta and p56(lck), and in a subset, reduced levels of these TCRzeta associated molecules are seen that may increase during cytokine-based therapy.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
8	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
15	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	that	that	PRON	WDT	PronType=Dem	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
39	during	during	ADP	IN	_	_	_	_	_
40	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 821
# text = Abnormal activation of NFkappaB is also present in >50% of patients and may also revert to normal during IL-2/IFN alpha-based treatment.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
10	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	normal	normal	VERB	VB	VerbForm=Inf	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 822
# text = This alteration in NFkappaB activation occurred in the presence of normal expression of TCRzeta-associated signaling elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 823
# text = The clinical significance of these findings remains unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
7	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 824
# text = Document 00300272 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300272	00300272	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 825
# text = Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C	c	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
11	synergistically	synergistically	ADV	RB	_	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 826
# text = We have earlier found that in Jurkat cells activation of protein kinase C (PKC) enhances the cyclic adenosine monophosphate (cAMP) accumulation induced by adenosine receptor stimulation or activation of Gs.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	earlier	earlier	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
20	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
21	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Gs	g	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 827
# text = Here we have therefore examined the effect of the phorbol ester PMA (phorbol 12-myristate 13-acetate) which stimulates PKC and a combination of the adenosine receptor agonist NECA (5'-(N-ethyl)-carboxamido adenosine) and forskolin to raise cAMP, on the levels of c-Fos and Jun and on the binding and transcriptional activity of the transcription factor, activator protein-1 (AP-1).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	therefore	therefore	ADV	RB	_	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
18	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	adenosine	adenosine	ADJ	JJ	Degree=Pos	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
32	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
33	NECA	NECA	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	'-(	'-(	PUNCT	.	_	_	_	_	SpaceAfter=No
37	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	ethyl	ethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	carboxamido	carboxamido	NOUN	NN	Number=Sing	_	_	_	_
42	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	forskolin	forskolin	VERB	VB	VerbForm=Inf	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
48	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	Fos	Fo	PROPN	NNP	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	on	on	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
65	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
69	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	,	,	PUNCT	,	_	_	_	_	_
71	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
72	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
74	1	1	NUM	CD	NumType=Card	_	_	_	_
75	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
76	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
80	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 828
# text = PMA treatment caused a concentration- and time-dependent increase in both c-Fos and Jun immunoreactivity in contrast to cAMP elevation that had only a slight effect.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
18	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	cAMP	camp	VERB	VB	VerbForm=Inf	_	_	_	_
23	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 829
# text = Both PMA and the combination of NECA and forskolin acted together either to increase (c-Fos) or decrease (Jun) protein levels as well as increasing AP-1 binding, as judged by gel-shift assay, and AP-1 transcriptional activity.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NECA	NECA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	forskolin	forskolin	PROPN	NNP	Number=Sing	_	_	_	_
10	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	together	together	ADV	RB	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	as	as	SCONJ	IN	_	_	_	_	_
37	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
42	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 830
# text = Furthermore there was a clear-cut synergy between the PKC stimulator and the cAMP elevating agents.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	_
2	there	there	PRON	EX	_	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cut	cut	ADJ	JJ	Degree=Pos	_	_	_	_
8	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
12	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	elevating	elevate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 831
# text = The results demonstrate that the simultaneous activation of PKC and elevation of cAMP leads to an enhanced AP-1 transcriptional activity in a T-leukemia cell line, suggesting that the previously observed interaction between the parallel signal transduction pathways may have functional consequences at the level of gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
14	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	previously	previously	ADV	RB	_	_	_	_	_
34	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
35	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
36	between	between	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
39	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
40	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
41	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
42	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
43	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
44	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
45	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
46	at	at	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	level	level	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 832
# text = Document 00300273 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300273	00300273	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 833
# text = Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	signalsome	signalsome	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
17	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 834
# text = The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
17	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 835
# text = This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
35	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
48	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
60	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
61	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
66	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
69	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 836
# text = Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
1	Kinase	Kinase	ADJ	JJ	Degree=Pos	_	_	_	_
2	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	lived	lived	ADJ	JJ	Degree=Pos	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IKK	IKK	NUM	CD	NumType=Card	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
22	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	alpha	alpha	ADV	RB	_	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	_
37	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 837
# text = In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	INTJ	UH	_	_	_	_	_
5	predominantly	predominantly	ADV	RB	_	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	slowly	slowly	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	30	30	NUM	CD	NumType=Card	_	_	_	_
19	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 838
# text = A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	_
10	point	point	NOUN	NN	Number=Sing	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	beta	beta	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 839
# text = The endogenous levels of the signalsome components were unaffected by stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	unaffected	unaffect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 840
# text = Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 841
# text = Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
9	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
18	disappearance	disappearance	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	reassembly	reassembly	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	signalsome	signalsome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	IKK	Ikk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
37	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	associated	associate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 842
# text = NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
1	NIK	NIK	ADV	RB	_	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
3	not	not	PART	RB	_	_	_	_	_
4	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
5	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	functionally	functionally	ADV	RB	_	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	effectively	effectively	ADV	RB	_	_	_	_	_
33	than	than	ADP	IN	_	_	_	_	_
34	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 843
# text = Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	stimulus	stimulus	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	whereas	SCONJ	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 844
# text = The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	treat	treat	VERB	VB	VerbForm=Inf	_	_	_	_
20	sepsis-	sepsis-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 845
# text = Document 00300274 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300274	00300274	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 846
# text = Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner.
1	Extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
29	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 847
# text = When immunoglobulin
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 848
# text = (Ig) expressing B cells are fused with non-B cells, Ig expression is rapidly suppressed at the level of transcription, a phenomenon termed extinction.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	non	non	X	AFX	_	_	_	_	SpaceAfter=No
11	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
27	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 849
# text = Here we demonstrate that fusion of HeLa cells with either diploid or tetraploid B cells (Daudi) results in widespread extinction of several other B cell-encoded genes that are expressed in a B cell-specific manner.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	diploid	diploid	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	tetraploid	tetraploid	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
22	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 850
# text = In contrast, expression of B cell-expressed genes that are not dependent on cell-specific controls is unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 851
# text = We show that the molecular mechanism(s) underlying Ig gene extinction can be explained, at least in part, by a lack of transcription factors that are essential for Ig gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ig	ig	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	SCONJ	IN	_	_	_	_	_
33	Ig	ig	VERB	VBG	VerbForm=Ger	_	_	_	_
34	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 852
# text = These transcription factors are either not produced due to block of transcription of their respective genes (Oct-2, OBF-1, PU.1), or are rendered inactive posttranslationally (NF-kappa B, E47).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	either	either	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	due	due	ADP	IN	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	block	block	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	rendered	render	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	posttranslationally	posttranslationally	ADV	RB	_	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	E47	E47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 853
# text = By isolating Daudi x
1	By	by	SCONJ	IN	_	_	_	_	_
2	isolating	isolate	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
4	x	x	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 854
# text = HeLa heterokaryons a few hours after fusion, we have studied the initial fate of two B cell-specific transcription factors involved in Ig gene transcription, Oct-2 and NF-kappa B.
1	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
2	heterokaryons	heterokaryon	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
5	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
14	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
26	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 855
# text = This report provides the first demonstration that upon fusion with HeLa cells, the nuclear contents of B cell-expressed transcription factors are depleted within a few hours with kinetics that are as fast or faster than that of Ig gene extinction.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	report	report	NOUN	NN	Number=Sing	_	_	_	_
3	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	upon	upon	ADP	IN	_	_	_	_	_
9	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	contents	contents	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
29	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	faster	faster	ADJ	JJR	Degree=Cmp	_	_	_	_
38	than	than	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 856
# text = Thus, the extinguishing mechanism is effective very early after fusion.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extinguishing	extinguishing	NOUN	NN	Number=Sing	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
8	very	very	ADV	RB	_	_	_	_	_
9	early	early	ADV	RB	Degree=Pos	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 857
# text = We suggest that extinction of Ig genes is part of a global mechanism that suppresses the differentiation program foreign to the HeLa phenotype.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	part	part	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	global	global	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	program	program	NOUN	NN	Number=Sing	_	_	_	_
19	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
23	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 858
# text = Document 00300275 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300275	00300275	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 859
# text = Sequential development of structural and functional alterations in T cells from tumor-bearing mice.
1	Sequential	Sequential	ADJ	JJ	Degree=Pos	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	bearing	bearing	VERB	VBG	VerbForm=Ger	_	_	_	_
15	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 860
# text = The TCR alpha beta or -gamma delta chains bind the peptide ligand, whereas the associated CD3 deltaepsilongamma and TCR zeta subunits couple the TCR to intracellular signal transduction components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	ADP	IN	_	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
9	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
10	bind	bind	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
19	deltaepsilongamma	deltaepsilongamma	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
23	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
24	couple	couple	NOUN	NN	Number=Sing	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
31	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 861
# text = Recently, several groups have described marked alterations in signal transduction elements in T cells from cancer patients or in mice bearing tumor for a few weeks (>26 days).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
27	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	>26	>26	NUM	CD	NumType=Card	_	_	_	_
30	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 862
# text = The sequence in which these alterations develop is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
7	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 863
# text = The aim of this study was to explore the kinetics of the development of alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck)) in mice bearing MC38 colon adenocarcinoma.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
40	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
41	MC38	MC38	NUM	CD	NumType=Card	_	_	_	_
42	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
43	adenocarcinoma	adenocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 864
# text = The results demonstrate that alterations in NF kappaB family proteins, specifically the failure of p65 translocation to the nucleus, occur earlier and more frequently than the decrease in zeta-chain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	more	more	ADV	RBR	_	_	_	_	_
26	frequently	frequently	ADV	RB	_	_	_	_	_
27	than	than	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 865
# text = These defects are paralleled by an impaired ability to produce Th1 cytokines (IL-2 and IFN-gamma).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
8	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
11	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 866
# text = These initial changes are followed by the eventual loss of TCR zeta chain and p56(lck) and a marked decrease in cytotoxic function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 867
# text = An increased rate of lysosomal degradation is one of the mechanisms responsible for the loss of zeta-chain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 868
# text = Document 00300276 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300276	00300276	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 869
# text = Thymocytes control the CD4 gene differently from mature T lymphocytes.
1	Thymocytes	Thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	differently	differently	ADV	RB	_	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 870
# text = We analyzed the activity of the enhancer, the promoter and the silencer of the human CD4 gene during T cell development using transgenic mice.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 871
# text = Immunofluorescence studies on thymic populations of mice carrying transgenes in various combinations of these regulatory DNA elements revealed that thymocytes control the CD4 gene in a different manner than mature peripheral T lymphocytes.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
5	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
9	transgenes	transgene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
31	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	NOUN	NN	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 872
# text = The 5'-positive regulatory unit, consisting of the promoter and the 5' enhancer, is already active at the CD4-CD8-double-negative (DN) stage of development.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	's	PUNCT	``	_	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	already	already	ADV	RB	_	_	_	_	_
21	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CD4-CD8	CD4-CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	DN	DN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 873
# text = However, its activity becomes lower in the double-positive and a fraction of the CD4+ CD8int/- cell population, indicating that an additional enhancer, located in either the first or the third intron of the CD4 gene, is required for CD4 gene expression in this population.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	CD8int	CD8int	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	/-	/-	PUNCT	.	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	either	either	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
39	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
43	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
49	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
53	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 874
# text = The other studied regulatory element is the minimal CD4 silencer which inhibits CD4 gene expression in peripheral CD8 T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
10	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 875
# text = This silencer is inactive in the most immature DN thymocytes, which probably use a distinct silencer mechanism to down-regulate CD4 gene expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	most	most	ADV	RBS	_	_	_	_	_
8	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
9	DN	Dn	NOUN	NN	Number=Sing	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	probably	probably	ADV	RB	_	_	_	_	_
14	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 876
# text = Unexpectedly, the CD4 silencer is also active in CD4+ CD8int/- cells of the thymus, implying that an anti-silencer may be required to resume CD4 expression in this cell population.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	CD8int	CD8int	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/-	/-	PUNCT	.	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	implying	imply	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	anti-silencer	anti-silencer	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	resume	resume	VERB	VB	VerbForm=Inf	_	_	_	_
28	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 877
# text = Altogether, the CD4 gene is regulated by several positive and negative regulatory mechanisms which come into play in a developmentally coordinated manner.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	come	come	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	play	play	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	developmentally	developmentally	ADV	RB	_	_	_	_	_
22	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 878
# text = Document 00300277 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300277	00300277	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 879
# text = Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	4E	4e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	BP2	Bp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
16	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 880
# text = Human myeloid differentiation is accompanied by a decrease in cell proliferation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 881
# text = Because the translation rate is an important determinant of cell proliferation, we have investigated translation initiation during human myeloid cell differentiation using the HL-60 promyelocytic leukemia cell line and the U-937 monoblastic cell line.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
17	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	60	60	NUM	CD	NumType=Card	_	_	_	_
28	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	937	937	NUM	CD	NumType=Card	_	_	_	_
37	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 882
# text = A decrease in the translation rate is observed when the cells are induced to differentiate along the monocytic/macrophage pathway or along the granulocytic pathway.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	along	along	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 883
# text = The inhibition in protein synthesis correlates with specific regulation of two repressors of translation initiation, 4E-BP1 and 4E-BP2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	BP1	Bp1	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	BP2	Bp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 884
# text = Induction of HL-60 and U-937 cell differentiation into monocytes/macrophages by IFN-gamma or PMA results in a dephosphorylation and consequent activation of 4E-BP1.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
22	results	result	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 885
# text = Dephosphorylation of 4E-BP1 was also observed when U-937 cells were induced to differentiate into monocytes/macrophages following treatment with retinoic acid or DMSO.
1	Dephosphorylation	Dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	937	937	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
26	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 886
# text = In contrast, treatment of HL-60 cells with retinoic acid or DMSO, which results in a granulocytic differentiation of these cells, decreases 4E-BP1 amount without affecting its phosphorylation and strongly increases 4E-BP2 amount.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	DET	WDT	PronType=Int	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	4E	4e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	BP1	Bp1	PROPN	NNP	Number=Sing	_	_	_	_
30	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
31	without	without	SCONJ	IN	_	_	_	_	_
32	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	strongly	strongly	ADV	RB	_	_	_	_	_
37	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	BP2	Bp2	NUM	CD	NumType=Card	_	_	_	_
41	amount	amount	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 887
# text = Taken together, these data provide evidence for differential regulation of the translational machinery during human myeloid differentiation, specific to the monocytic/macrophage pathway or to the granulocytic pathway.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
14	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 888
# text = Document 00300278 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300278	00300278	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 889
# text = Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	converting	convert	VERB	VBG	VerbForm=Ger	_	_	_	_
22	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
25	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 890
# text = Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells.
1	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 891
# text = Restimulation of T cell blasts up-regulates Fas and Fas ligand expression, with subsequent interaction leading to cell death.
1	Restimulation	Restimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
5	blasts	blast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
9	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
12	ligand	ligand	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
21	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 892
# text = Overexpression of Bcl-2 in tumor cells blocks apoptosis induced by many stimuli, but inhibition of Fas-mediated killing has not been consistently observed.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	tumor	tumor	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
14	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	killing	killing	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	consistently	consistently	ADV	RB	_	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 893
# text = To examine the behavior of Bcl-2 in normal cells, T cell blasts were transiently transfected with Bcl-2 and related gene products to determine the effect on apoptotic signaling.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	transiently	transiently	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 894
# text = Transient overexpression of Bcl-2 in mouse and human T cell blasts did not block Fas-mediated apoptosis, whereas etoposide- and glucocorticoid-induced cytotoxicity was potently inhibited.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
17	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	wherea	ADV	RB	_	_	_	_	_
22	etoposide	etoposide	ADV	RB	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	potently	potently	ADV	RB	_	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 895
# text = Expression of Bcl-xL and adenovirus E1B 19K did not interfere with anti-Fas killing.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	adenovirus	adenovirus	PROPN	NNP	Number=Sing	_	_	_	_
8	E1B	E1B	PROPN	NNP	Number=Sing	_	_	_	_
9	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	K	k	NUM	CD	NumType=Card	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	anti	anti	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-Fas	-Fas	SCONJ	IN	_	_	_	_	_
17	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 896
# text = In contrast, interleukin-1beta-converting enzyme family protease inhibitors Ac-DEVD-CHO and CrmA blocked Fas-mediated apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
10	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
14	Ac-	Ac-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	DEVD	DEVD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CrmA	CrmA	PROPN	NNP	Number=Sing	_	_	_	_
20	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 897
# text = These results suggest that peripheral T cells use distinct apoptosis signaling pathways with differential sensitivity to Bcl-2 and interleukin-1beta-converting enzyme family protease inhibitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	converting	convert	VERB	VBG	VerbForm=Ger	_	_	_	_
26	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
29	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 898
# text = Since T cells normally express Bcl-2 and Bcl-xL following activation, their inability to block Fas-mediated apoptosis may allow for the elimination of self-reactive cells and the appropriate regulation of immune responses.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
13	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
20	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	elimination	elimination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
39	responses	respons	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 899
# text = Document 00300279 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300279	00300279	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 900
# text = Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	pokeweed	pokeweed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 901
# text = The present studies have examined the effects of pokeweed mitogen (PWM) on the induction of early growth response-1 gene (EGR-1) in normal human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	pokeweed	pokeweed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 902
# text = PWM regulates EGR-1 gene expression by both transcriptional and post-transcriptional mechanisms.
1	PWM	PWM	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	post-transcriptional	post-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 903
# text = Transient transfection assays with EGR-1 promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene demonstrated that PWM induced EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
14	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	gene	gene	PRON	NN	Number=Sing	_	_	_	_
19	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
22	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
32	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	C	C	PROPN	NNP	Number=Sing	_	_	_	_
35	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	6GG	6gg	INTJ	UH	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 904
# text = The results further demonstrated the activation of S6 kinase (pp90rsk), evidenced by phosphorylation of S6 and serum response factor (SRF) peptides, in PWM treated B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	S6	S6	NUM	CD	NumType=Card	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	S6	s6	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
30	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 905
# text = Taken together, these findings suggest that PWM is able to initiate an intracytoplasmic signalling cascade and EGR-1 induction in normal human B cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
16	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 906
# text = Document 00300280 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300280	00300280	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 907
# text = Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transdominant	transdominant	ADJ	JJ	Degree=Pos	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 908
# text = The KBF1 factor, which binds to the enhancer
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 909
# text = A located in the promoter of the mouse MHC class I gene H-2Kb, is indistinguishable from the p50 DNA binding subunit of the transcription factor NF-kappa B, which regulates a series of genes involved in immune and inflammatory responses.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Kb	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
25	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	series	series	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
46	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 910
# text = The KBF1/p50 factor binds as a homodimer but can also form heterodimers with the products of other members of the same family, like the c-rel and v-rel (proto)oncogenes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	KBF	KBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
15	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	products	product	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	members	member	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	like	like	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	v-rel	v-rel	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 911
# text = The dimerization domain of KBF1/p50 is contained between amino acids 201 and 367.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	KBF	KBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	amino	amino	DET	DT	_	_	_	_	_
13	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
14	201	201	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	367	367	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 912
# text = A mutant of KBF1/p50 (delta SP), unable to bind to DNA but able to form homo- or heterodimers, has been constructed.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	KBF1/	Kbf1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
8	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
20	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 913
# text = This protein reduces or abolishes in vitro the DNA binding activity of wild-type proteins of the same family (KBF1/p50, c- and v-rel).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	reduces	reduce	NOUN	NNS	Number=Plur	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	abolishes	abolish	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	KBF	KBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	1/	1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 914
# text = This mutant also functions in vivo as a trans-acting dominant negative regulator:
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	trans	tran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	NOUN	NN	Number=Sing	_	_	_	_
14	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 915
# text = the transcriptional inducibility of the HIV long terminal repeat (which contains two potential NF-kappa B binding sites) by phorbol ester (PMA) is inhibited when it is co-transfected into CD4+ T cells with the delta SP mutant.
1	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
24	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	when	when	ADV	WRB	PronType=Int	_	_	_	_
31	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	into	into	ADP	IN	_	_	_	_	_
35	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	T	t	NUM	CD	NumType=Card	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
42	SP	sp	PROPN	NNP	Number=Sing	_	_	_	_
43	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 916
# text = Similarly the basal as well as TNF or IL1-induced activity of the MHC class I H-2Kb promoter can be inhibited by this mutant in two different cell lines.
1	Similarly	similarly	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IL1	IL1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
16	class	class	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	H	h	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	Kb	kb	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 917
# text = These results constitute the first formal demonstration that these genes are regulated by members of the rel/NF-kappa B family.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	constitute	constitute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADV	RBS	_	_	_	_	_
6	formal	formal	ADJ	JJ	Degree=Pos	_	_	_	_
7	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rel/	rel/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 918
# text = Document 00300281 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300281	00300281	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 919
# text = Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	association	association	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 920
# text = Using the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	coiled	coil	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	coil	coil	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	b	b	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	bait	bait	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
19	screen	screen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	association	association	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
32	function	function	NOUN	NN	Number=Sing	_	_	_	_
33	previously	previously	ADV	RB	_	_	_	_	_
34	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
40	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 921
# text = We further show that Nmi interacts with all STATs except Stat2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	_
10	except	except	ADP	IN	_	_	_	_	_
11	Stat2	stat2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 922
# text = We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
17	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
18	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 923
# text = Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
4	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
14	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	p300	p300	NUM	CD	NumType=Card	_	_	_	_
21	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	together	together	ADV	RB	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	p300	p300	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 924
# text = Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
12	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
24	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	at	at	ADV	RB	_	_	_	_	_
29	least	least	ADV	RBS	Degree=Sup	_	_	_	_
30	some	some	DET	DT	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	group	group	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 925
# text = Document 00300282 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300282	00300282	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 926
# text = Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	like	like	ADP	IN	_	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	set	set	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 927
# text = We previously identified the P sequence as a critical regulatory element of the human IL-4 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	P	p	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 928
# text = In the mouse IL-4 promoter, there are five elements homologous to the human P sequence designated conserved lymphokine element 0 (CLE0), P, P2, P3 and P4.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	there	there	PRON	EX	_	_	_	_	_
10	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	five	five	NUM	CD	NumType=Card	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	0	0	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	P2	p2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	P3	P3	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	P4	p4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 929
# text = To characterize the role of these P-like elements and their binding factors in the native promoter, we did transient transfection and electrophoretic mobility shift assays (EMSA).
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	like	like	ADP	IN	_	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
22	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 930
# text = Transfection of EL-4 cells with the IL-4 promoter-reporter constructs carrying mutated P-like elements showed that four P-like elements, CLE0, P, P2 and P4, but not P3, were required for optimal activation of the IL-4 promoter.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	EL	EL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
16	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
17	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	like	like	ADP	IN	_	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	four	four	NUM	CD	NumType=Card	_	_	_	_
24	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	P2	P2	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	P4	P4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	P3	P3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	4	4	NUM	CD	NumType=Card	_	_	_	_
51	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 931
# text = EMSA showed that both constitutive and inducible complexes bound to CLE0, P, P2 and P4, whereas only a constitutive complex bound to P3.
1	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	P2	P2	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	P4	P4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	P3	P3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 932
# text = In competition and antibody supershift assays in EMSA, complexes formed with P or P2 proved to contain nuclear factor of activated T cells (NFAT) family proteins as major components.
1	In	in	ADP	IN	_	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
5	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	P	p	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	P2	p2	NOUN	NN	Number=Sing	_	_	_	_
16	proved	prove	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 933
# text = Activator protein (AP)-1 family proteins interacted with CLE0, P, P2 and P4. NFAT
1	Activator	Activator	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	interacted	interact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	P2	p2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	P4	p4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 934
# text = /AP-1 complex formed only with P and P2.
1	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	P	p	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	P2	p2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 935
# text = Cross-competition assays among the P-like elements revealed element-specific and common complexes.
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-competition	-competition	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	among	among	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	like	like	ADP	IN	_	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 936
# text = Six tandem repeats of the P element linked to the SV40 promoter responded to phorbol 12-myristate 13-acetate, while that of other elements did not.
1	Six	six	NUM	CD	NumType=Card	_	_	_	_
2	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
3	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	P	P	PROPN	NNP	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 937
# text = It would thus appear that components of each P-like element-binding complexes are not identical and may coordinately contribute to transcriptional activity.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	like	like	ADP	IN	_	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	coordinately	coordinately	ADV	RB	_	_	_	_	_
21	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 938
# text = Document 0030010 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030010	0030010	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 939
# text = HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes [see comments]
1	HIV	haHive	NOUN	NN	Number=Sing	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	perpetuated	perpetuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 940
# text = Permissiveness to replication of human immunodeficiency virus (HIV) differs in T lymphocytes and macrophages.
1	Permissiveness	Permissiveness	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 941
# text = In T cells, HIV transcription is poorly detected in vivo.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	poorly	poorly	ADV	RB	_	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 942
# text = Cloned, normal T lymphocytes show very little, if any, basal activity of the HIV enhancer and low nuclear expression of NF-kappa B, a potent transcriptional activator of the HIV enhancer.
1	Cloned	Cloned	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	little	little	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	if	if	SCONJ	IN	_	_	_	_	_
11	any	any	DET	DT	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 943
# text = In contrast, fixed tissue macrophages express detectable HIV proteins, indicating permanent virus transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 944
# text = One explanation for the perpetuation of virus infection in macrophages could be sustained nuclear NF-kappa B expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	perpetuation	perpetuation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 945
# text = However, the U937 monocytic cell line, which is fully permissive to HIV replication, is known to express only low levels of nuclear NF-kappa B.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	fully	fully	ADV	RB	_	_	_	_	_
12	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 946
# text = We show here that chronic HIV infection results in both induction of a nuclear factor with antigenic properties indistinguishable from those of NF-kappa B and permanently increased HIV enhancer activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
19	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	permanently	permanently	ADV	RB	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 947
# text = This phenomenon, which is independent of tumour necrosis factor, is associated with HIV replication, and is thus likely to explain at least in part the perpetuation of HIV infection in monocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
9	necrosis	necrosis	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
24	at	at	ADV	RB	_	_	_	_	_
25	least	least	ADV	RBS	Degree=Sup	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	part	part	NOUN	NN	Number=Sing	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	perpetuation	perpetuation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
32	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 948
# text = Document 0030011 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011	0030011	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 949
# text = Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	Oct-2	Oct-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	group	group	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
15	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 950
# text = The class II major histocompatibility complex gene HLA-DRA is expressed in B cells, activated T lymphocytes, and in antigen-presenting cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	presenting	presenting	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 951
# text = In addition, HLA-DRA gene expression is inducible in a variety of cell types by interferon-gamma (IFN-gamma).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 952
# text = Here we show that the lymphoid-specific transcription factor Oct-2A plays a critical role in HLA-DRA gene expression in class II-positive B cell lines, and that the high mobility group protein (HMG) I/Y binds to multiple sites within the DRA promoter, including the Oct-2A binding site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	A	a	NOUN	NN	Number=Sing	_	_	_	_
15	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	class	class	NOUN	NN	Number=Sing	_	_	_	_
27	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
38	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
39	group	group	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	I/Y	I/y	DET	DT	_	_	_	_	_
45	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
48	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
49	within	within	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
61	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 953
# text = Coexpression of HMG I/Y and Oct-2 in cell lines lacking Oct-2 results in high levels of HLA-DRA gene expression, and in vitro DNA-binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
4	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
34	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
37	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
38	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	A	a	NOUN	NN	Number=Sing	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	HLA	HLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 954
# text = Thus, Oct-2A and HMG I/Y may synergize to activate HLA-DRA expression in B cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
6	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	HLA	HLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 955
# text = By contrast, Oct-2A is not involved in the IFN-gamma induction of the HLA-DRA gene in HeLa cells, but antisense HMG I/Y dramatically decreases the level of induction.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	A	a	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
29	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
30	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
31	dramatically	dramatically	ADV	RB	_	_	_	_	_
32	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 956
# text = We conclude that distinct sets of transcription factors are involved in the two modes of HLA-DRA expression, and that HMG I/Y may be important for B cell-specific expression, and is essential for IFN-gamma induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	modes	mode	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
24	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 957
# text = Document 0030012 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012	0030012	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 958
# text = Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
16	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 959
# text = The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	causative	causative	ADJ	JJ	Degree=Pos	_	_	_	_
17	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 960
# text = Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	leukemogenesis	leukemogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	still	still	ADV	RB	_	_	_	_	_
15	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 961
# text = This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
5	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
13	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
14	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 962
# text = Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	lead	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	F	F	PROPN	NNP	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
20	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
28	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 963
# text = In this paper, we demonstrate that Tax can also activate E2F-mediated transcription independently of p16(INK4A).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	E2F	E2f	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	independently	independently	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 964
# text = Indeed, when Tax is coexpressed with the E2F-1 transcription factor in CEM T-cells, which lack expression of p16(INK4A), it strongly potentiates the E2F-dependent activation of a reporter construct driven by a promoter containing E2F binding sites.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
16	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	strongly	strongly	ADV	RB	_	_	_	_	_
31	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	E2F	E2f	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
41	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
45	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
46	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	F	F	SCONJ	IN	_	_	_	_	_
48	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 965
# text = This stimulation is abrogated by mutations affecting the E2F-binding sites.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 966
# text = In addition, Tax also stimulates the transcription of the E2F-1 gene itself.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 967
# text = Using Tax mutants that fail to activate either ATF- or NF-kappaB-dependent promoters and different 5' truncation mutants of the E2F-1 promoter, we show that the Tax-dependent transcriptional control of the E2F1 gene involves, at least in part, the ATF binding site located in the E2F-1 promoter.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	either	either	CCONJ	CC	_	_	_	_	_
9	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	''	_	_	_	_	_
22	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
23	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	control	control	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	E2F1	E2F1	PROPN	NNP	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	involves	involve	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	at	at	ADV	RB	_	_	_	_	_
47	least	least	ADV	RBS	Degree=Sup	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	ATF	Atf	SCONJ	IN	_	_	_	_	_
53	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
54	site	site	NOUN	NN	Number=Sing	_	_	_	_
55	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	E2F	E2F	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	_
61	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 968
# text = Document 0030013 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013	0030013	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 969
# text = Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	ADV	RB	_	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 970
# text = Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis.
1	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
7	ligand	ligand	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	CD95L	Cd95l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	interacting	interact	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
17	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 971
# text = Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis.
1	Lymphocyte	Lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	FasL	FasL	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 972
# text = Although Fas upregulation is central to the preservation of immunologic tolerance, little is known about the molecular machinery underlying this process.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
3	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	preservation	preservation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
11	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	about	about	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
20	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 973
# text = To investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	_
11	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	fas	fa	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
35	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
36	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	P/	Pith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
45	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 974
# text = Although resting Jurkat cells express Fas, Fas mRNA was induced approximately 10-fold in 2 h upon P/I stimulation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	P/I	P/I	PROPN	NNP	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 975
# text = Using sequential deletion mutants of the human fas promoter in transient transfection assays, we identified a 47-bp sequence (positions -306 to -260 relative to the ATG) required for activation-driven fas upregulation.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	sequential	sequential	ADJ	JJ	Degree=Pos	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	fas	fas	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
13	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	306	306	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	260	260	NUM	CD	NumType=Card	_	_	_	_
29	relative	relative	ADV	RB	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	ATG	ATG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	fas	fas	NOUN	NNS	Number=Plur	_	_	_	_
40	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 976
# text = Sequence analysis revealed the presence of a previously unrecognized composite binding site for both the Sp1 and NF-kappaB transcription factors at positions -295 to -286.
1	Sequence	Sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
10	composite	composite	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	295	295	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	286	286	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 977
# text = Electrophoretic mobility shift assay (EMSA) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of p50-p65 NF-kappaB heterodimers after P/I activation.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	supershift	supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
10	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
16	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
34	after	after	ADP	IN	_	_	_	_	_
35	P/	p/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	activation	activation	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 978
# text = Sp1 and NF-kappaB transcription factor binding was shown to be mutually exclusive by EMSA displacement studies with purified recombinant Sp1 and recombinant p50.
1	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	mutually	mutually	ADV	RB	_	_	_	_	_
14	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
17	displacement	displacement	NOUN	NN	Number=Sing	_	_	_	_
18	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
22	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
25	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 979
# text = The functional contribution of the kappaB-Sp1 composite site in P/I-inducible fas promoter activation was verified by using kappaB-Sp1 concatamers (-295 to -286) in a thymidine kinase promoter-driven reporter construct and native promoter constructs in Jurkat cells overexpressing IkappaB-alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
9	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	P/I	P/I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	fas	fas	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	verified	verify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
24	concatamers	concatamer	NOUN	NNS	Number=Plur	_	_	_	_
25	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
26	295	295	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	286	286	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
39	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
47	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
48	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 980
# text = Site-directed mutagenesis of the critical guanine nucleotides in the kappaB-Sp1 element documented the essential role of this site in activation-dependent fas promoter induction.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
8	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
9	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	fas	fas	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 981
# text = Document 0030014 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030014	0030014	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 982
# text = HIV type 1 protease activation of NF-kappa B within T lymphoid cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 983
# text = NF-kappa B is a nuclear protein of the rel oncogene family capable of enhancing transcription of several cellular genes, including IL-2 and the IL-2 receptor, and viral genes transcribed from the HIV-1 LTR.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
12	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	SCONJ	IN	_	_	_	_	_
16	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
37	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 984
# text = It has been reported that HIV-1 protease may cleave the NF-kappa B precursor to its active form in vitro.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	cleave	cleave	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	form	form	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 985
# text = In this study the effects of HIV protease on NF-kappa B precursor activation were examined in Jurkat T cells by introducing a protease expression vector into the cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
8	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	introducing	introduce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 986
# text = Increased NF-kappa B activity was observed and this increased activity was blocked by a specific inhibitor of the viral protease.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	protease	protease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 987
# text = Viral transcription, as measured using LTR-CAT assays, was only slightly enhanced in the HIV-protease expressing cells, while secretion of IL-2 and expression of the IL-2 receptor were not affected.
1	Viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	slightly	slightly	ADV	RB	_	_	_	_	_
15	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV-	Hiv-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 988
# text = The limited activation of NF-kappa B by HIV protease appears unlikely to have a significant effect on virus expression or T cell function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	unlikely	unlikely	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 989
# text = Document 0030015 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030015	0030015	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 990
# text = The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 991
# text = OBJECTIVES:
1	OBJECTIVES	objective	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 992
# text = To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 993
# text = DESIGN AND METHODS:
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 994
# text = The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
11	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	H9	H9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
30	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
42	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 995
# text = The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	RAR	RAR	NOUN	NN	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	hRAR	hrar	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	all	all	DET	DT	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
17	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	X	x	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	hRXR	hrxr	X	GW	_	_	_	_	_
29	alpha	alpha	X	GW	_	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
35	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
41	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
42	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 996
# text = RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Both	both	DET	DT	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
11	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	co-stimulatory	co-stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
34	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
35	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
36	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 997
# text = The retinoids had weak or no stimulatory effects on HIV production by T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 998
# text = HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 999
# text = The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
5	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	generally	generally	ADV	RB	_	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
14	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
22	generally	generally	ADV	RB	_	_	_	_	_
23	more	more	ADV	RBR	_	_	_	_	_
24	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
28	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
29	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1000
# text = Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	H9	H9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	U937	U937	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	almost	almost	ADV	RB	_	_	_	_	_
18	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1001
# text = Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	_
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	weakly	weakly	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1002
# text = After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells.
1	After	after	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	RXR	RXR	X	GW	_	_	_	_	_
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	U937	U937	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1003
# text = Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	unchanged	unchange	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	U937	U937	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1004
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1005
# text = The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1006
# text = Endogenous or exogenously administered RA may have a significant role in HIV regulation.
1	Endogenous	Endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	exogenously	exogenously	ADV	RB	_	_	_	_	_
4	administered	administer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1007
# text = Document 0030016 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030016	0030016	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1008
# text = Mycobacterium tuberculosis mannose-capped lipoarabinomannan can induce NF-kappaB-dependent activation of human immunodeficiency virus type 1 long terminal repeat in T cells.
1	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
2	tuberculosis	tuberculosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mannose	mannose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	capped	cap	ADJ	JJ	Degree=Pos	_	_	_	_
6	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
22	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
23	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1009
# text = Tuberculosis has emerged as an epidemic, extended by the large number of individuals infected with human immunodeficiency virus type 1 (HIV-1).
1	Tuberculosis	Tuberculosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	emerged	emerge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	epidemic	epidemic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	extended	extend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1010
# text = The major goal of this study was to determine whether the mycobacterial cell wall component mannose-capped lipoarabinomannan (ManLAM) of Mycobacterium tuberculosis (M.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	goal	goal	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
10	whether	whether	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	mannose	mannose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	capped	cap	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
25	tuberculosis	tuberculosis	PROPN	NNPS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1011
# text = tuberculosis) could activate transcription of HIV-1 in T cells with the use of an in vitro cell culture system.
1	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	use	use	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1012
# text = These experiments are of prime importance considering that CD4-expressing T lymphocytes represent the major virus reservoir in the peripheral blood of infected individuals.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	prime	prime	ADJ	JJ	Degree=Pos	_	_	_	_
6	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
7	considering	consider	VERB	VBG	VerbForm=Ger	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-expressing	-expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
21	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1013
# text = Using the 1G5 cell line harbouring the luciferase reporter gene under the control of the HIV-1 LTR, it was first found that culture protein filtrates (CFP) from M. tuberculosis or purified ManLAM could activate HIV-1 LTR-dependent gene expression unlike similarly prepared CFP extracts devoid of ManLAM.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	1G5	1G5	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	_
6	harbouring	harbour	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	first	first	ADV	RB	_	_	_	_	_
24	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	culture	culture	ADJ	JJ	Degree=Pos	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	filtrates	filtrate	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	CFP	CFP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
34	tuberculosis	tuberculosis	PROPN	NNPS	Number=Plur	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
37	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	_
38	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	_
43	LTR-	LTR-	X	AFX	_	_	_	_	SpaceAfter=No
44	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	unlike	unlike	ADP	IN	_	_	_	_	_
48	similarly	similarly	ADV	RB	_	_	_	_	_
49	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	CFP	Cfp	NOUN	NN	Number=Sing	_	_	_	_
51	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
52	devoid	devoid	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1014
# text = The implication of protein tyrosine kinase(s), protein kinase A and/or protein kinase C was highlighted by the abrogation of the ManLAM-mediated activation of HIV-1 LTR-driven gene expression using herbimycin A and H7.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	A	a	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	C	c	PROPN	NNP	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	highlighted	highlight	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
40	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
41	A	a	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	H7	H7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1015
# text = It was also determined, using electrophoresis mobility shift assays, that M. tuberculosis ManLAM led to the nuclear translocation of the transcription factor NF-kappaB.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	electrophoresis	electrophoresis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
9	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
14	tuberculosis	tuberculosis	PROPN	NNP	Number=Sing	_	_	_	_
15	ManLAM	ManLAm	PROPN	NNP	Number=Sing	_	_	_	_
16	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1016
# text = M. tuberculosis ManLAM resulted in clear induction of the luciferase gene placed under the control of the wild-type, but not the kappaB-mutated, HIV-1 LTR region.
1	M.	m.	PROPN	NNP	Number=Sing	_	_	_	_
2	tuberculosis	tuberculosis	PROPN	NNP	Number=Sing	_	_	_	_
3	ManLAM	ManLAm	PROPN	NNP	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	placed	place	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	under	under	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
32	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1017
# text = Finally, the ManLAM-mediated activation of HIV-1 LTR transcription was found to be independent of the autocrine or paracrine action of endogenous TNF-alpha.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	paracrine	paracrine	NOUN	NN	Number=Sing	_	_	_	_
24	action	action	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
27	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1018
# text = The results suggest that M. tuberculosis can upregulate HIV-1 expression in T cells and could thus have the potential to influence the pathogenesis of HIV-1 infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
6	tuberculosis	tuberculosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	thus	thus	ADV	RB	_	_	_	_	_
19	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1019
# text = Document 0030017 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030017	0030017	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1020
# text = Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1021
# text = Glucocorticoids have an inhibitory effect on inflammatory and immune responses, and this may be through the modulation of transcription factor binding to DNA.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1022
# text = The interaction of the transcription factors, activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
32	element	element	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
42	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
50	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
51	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
52	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
56	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
57	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
58	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1023
# text = TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	up	up	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	200	200	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	38	38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	over	over	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	min	min	NOUN	NN	Number=Sing	_	_	_	_
45	time	time	NOUN	NN	Number=Sing	_	_	_	_
46	course	course	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1024
# text = Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1, NF kappa B, and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	sustained	sustain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	concomitant	concomitant	NOUN	NN	Number=Sing	_	_	_	_
16	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
32	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1025
# text = These latter effects were due to increases in the nuclear localization of GR, not to reduced amounts of the other transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	due	due	ADP	IN	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	reduced	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
18	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1026
# text = This suggests that in these cells GR within the nucleus interacts with cytokine-stimulated transcription factors by the process of cross coupling.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	GR	Gr	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nucleus	nucleus	ADJ	JJ	Degree=Pos	_	_	_	_
11	interacts	interacts	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cross	cross	NOUN	NN	Number=Sing	_	_	_	_
23	coupling	coupling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1027
# text = This may be an important molecular site of steroid action.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1028
# text = Document 0030018 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030018	0030018	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1029
# text = Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay.
1	Competent	Competent	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
6	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	xeroderma	xeroderma	NOUN	NN	Number=Sing	_	_	_	_
15	pigmentosum	pigmentosum	NOUN	NN	Number=Sing	_	_	_	_
16	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	D	d	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	optimized	optimized	ADJ	JJ	Degree=Pos	_	_	_	_
23	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1030
# text = The human autosomal recessive disease, xeroderma pigmentosum (XP), can result from mutations in any one of seven genes, designated XPA through XPG.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	autosomal	autosomal	ADJ	JJ	Degree=Pos	_	_	_	_
4	recessive	recessive	ADJ	JJ	Degree=Pos	_	_	_	_
5	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	xeroderma	xeroderma	NOUN	NN	Number=Sing	_	_	_	_
8	pigmentosum	pigmentosum	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	any	any	DET	DT	_	_	_	_	_
19	one	one	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	seven	seven	NUM	CD	NumType=Card	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	XPA	XPA	PROPN	NNP	Number=Sing	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	XPG	XPG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1031
# text = Of these, the XPB and XPD genes encode proteins that are subunits of a general transcription factor, TFIIH, involved in both nucleotide excision repair (NER) and initiation of mRNA transcription by RNA polymerase II.
1	Of	of	ADP	IN	_	_	_	_	_
2	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	XPB	XPB	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	XPD	XPD	PROPN	NNP	Number=Sing	_	_	_	_
8	genes	gene	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	TFIIH	TFIIh	INTJ	UH	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
26	excision	excision	NOUN	NN	Number=Sing	_	_	_	_
27	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NER	NER	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
38	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
39	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1032
# text = In humans, mutation of the XPB or XPD gene impairs NER, resulting in hyper-sensitivity to sunlight and greatly increased skin tumor formation.
1	In	in	ADP	IN	_	_	_	_	_
2	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	XPB	XPB	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	XPD	XPD	AUX	MD	VerbForm=Fin	_	_	_	_
10	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
11	impairs	impairs	ADV	RB	_	_	_	_	_
12	NER	ner	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	hyper	hyper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	sunlight	sunlight	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	greatly	greatly	ADV	RB	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1033
# text = However, no transcription deficiency has been demonstrated in either XP-B or XP-D.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	either	either	DET	DT	_	_	_	_	_
11	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	B	B	PROPN	NNP	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1034
# text = We have employed an optimized cell-free RNA transcription assay to analyze transcription activity of XP-B and XP-D.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	optimized	optimized	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
9	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1035
# text = Although the growth rate was normal, the XP-B and XP-D cells contained reduced amounts of TFIIH.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	D	d	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	TFIIH	TFIIH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1036
# text = Extracts prepared from XP-B and XP-D lymphoblastoid cells exhibited similar transcription activity from the adenovirus major late promoter when compared to that in extracts from normal cells.
1	Extracts	Extract	NOUN	NNS	Number=Plur	_	_	_	_
2	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	D	d	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	when	when	ADV	WRB	PronType=Int	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1037
# text = Thus, we conclude that the XP-B and XP-D lymphoblastoid cells do not have impaired RNA transcription activity.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	XP	Xp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	XP	Xp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	D	d	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
19	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1038
# text = We consider the possible consequences of the reduced cellular content of TFIIH for the clinical symptoms in XP-B or XP-D patients, and discuss a 'conditional phenotype' that may involve an impairment of cellular function only under certain growth conditions.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	consider	consider	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	content	content	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TFIIH	TFIIh	PROPN	NNP	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
16	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	D	d	PROPN	NNP	Number=Sing	_	_	_	_
25	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	discuss	discuss	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
31	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
32	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	'	'	PUNCT	''	_	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	impairment	impairment	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
41	function	function	NOUN	NN	Number=Sing	_	_	_	_
42	only	only	ADV	RB	_	_	_	_	_
43	under	under	ADP	IN	_	_	_	_	_
44	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
45	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
46	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1039
# text = Document 0030019 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030019	0030019	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1040
# text = Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
10	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
11	produces	produce	NOUN	NNS	Number=Plur	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	silencing	silencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1041
# text = The chromatin structure of the human beta-globin gene locus assumes a transcriptionally-active conformation in erythroid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
3	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
12	assumes	assume	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1042
# text = One feature of this chromatin reorganization is the formation of DNase 1 hypersensitive sites in the regions of active globin gene promoters.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
6	reorganization	reorganization	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
20	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1043
# text = This reorganization requires the globin locus control region and is associated with normal expression of the beta-like globin genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	reorganization	reorganization	NOUN	NN	Number=Sing	_	_	_	_
3	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
6	locus	locus	CCONJ	CC	_	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	like	like	SCONJ	IN	_	_	_	_	_
20	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1044
# text = To determine whether it is possible to artificially enhance the opening of the chromatin structure of a minimal beta-globin promoter, we placed a 101bp, erythroid-specific DNase 1 hypersensitive site-forming element (HSFE) immediately upstream of the beta-globin promoter and gene.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	artificially	artificially	ADV	RB	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	opening	opening	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
15	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	placed	place	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	101	101	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
39	element	element	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	HSFE	HSFE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	immediately	immediately	ADV	RB	_	_	_	_	_
44	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1045
# text = This element includes binding sites for NF-E2, AP-1, GATA-1 and Sp-1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Sp	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1046
# text = Constructs were stably transfected into murine erythroleukemia cells and promoter chromatin structure and gene expression were analyzed.
1	Constructs	Construct	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	murine	murine	PRON	PRP	_	_	_	_	_
7	erythroleukemia	erythroleukemia	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
11	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
12	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1047
# text = The HSFE induced an area of enhanced DNase 1 hypersensitivity extending from the transcriptional start site to -300bp of the artificial promoter and significantly increased the proportion of beta-globin promoters in an open chromatin configuration.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HSFE	HSFE	PROPN	NNP	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	area	area	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	start	start	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	significantly	significantly	ADV	RB	_	_	_	_	_
27	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
34	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
38	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
39	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1048
# text = This remodeling of promoter chromatin structure resulted in 3-fold increases in beta-globin gene transcription and induction, and inhibited long-term beta-globin gene silencing.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
6	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
12	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	term	term	NOUN	NN	Number=Sing	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	silencing	silencing	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1049
# text = These results indicate that a relatively small cis-acting element is able to enhance remodeling of promoter chromatin structure resulting in increased beta-globin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	relatively	relatively	ADV	RB	_	_	_	_	_
7	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-acting	-acting	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
15	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
19	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
20	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1050
# text = Document 00300110 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300110	00300110	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1051
# text = Transcriptional control of steroid-regulated apoptosis in murine thymoma cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
10	thymoma	thymoma	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1052
# text = Early studies in murine T cell lines indicated that transcriptional transactivation functions encoded in the glucocorticoid receptor (GR)
1	Early	Early	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
13	encoded	encod	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 1053
# text = N-terminal domain are required for glucocorticoid-mediated apoptosis.
1	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1054
# text = However, more recent studies in human T cell lines have suggested that the N-terminal domain is not necessary for steroid-regulated apoptosis and that GR-mediated transrepression may be the more critical mechanism.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	more	more	ADV	RBR	_	_	_	_	_
4	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transrepression	transrepression	NOUN	NN	Number=Sing	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	more	more	ADV	RBR	_	_	_	_	_
36	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
37	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1055
# text = To better understand the contribution of the GR N-terminal transactivation domain in mediating murine thymocyte apoptosis, we stably transfected GR, GR variants, and the androgen receptor (AR) into receptor-negative S49 murine thymoma cells.
1	To	to	ADV	RB	_	_	_	_	_
2	better	better	ADV	RBR	Degree=Cmp	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
9	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	murine	murine	PRON	PRP	_	_	_	_	_
16	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
17	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	stably	stably	ADV	RB	_	_	_	_	_
21	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
25	variants	variant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	AR	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	into	into	ADP	IN	_	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
38	S49	s49	NOUN	NN	Number=Sing	_	_	_	_
39	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
40	thymoma	thymoma	ADP	IN	_	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1056
# text = GR expression levels were shown to be rate-limiting for initiating the apoptotic pathway, and a positive correlation between steroid sensitivity and GR-mediated induction of an integrated mouse mammary tumor virus (MMTV) LTR reporter gene was observed.
1	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	limiting	limit	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	initiating	initiat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	GR	Gr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
33	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
34	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
35	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
40	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1057
# text = Analysis of GR chimeric receptors containing the potent VP16 and E1A viral transactivation domains in place of the GR N terminus revealed that even low level expression of these receptors resulted in both enhanced steroid sensitivity and MMTV induction, thus supporting a role for transactivation in apoptosis.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
4	chimeric	chimeric	NOUN	NN	Number=Sing	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
9	VP16	VP16	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	place	place	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
21	N	N	PROPN	NNP	Number=Sing	_	_	_	_
22	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
27	level	level	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
32	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	both	both	CCONJ	CC	_	_	_	_	_
35	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	MMTV	Mmtv	NOUN	NN	Number=Sing	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	thus	thus	ADV	RB	_	_	_	_	_
43	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	role	role	NOUN	NN	Number=Sing	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1058
# text = In contrast, we found that AR can initiate apoptosis in S49 cells after treatment with 5 alpha-dihydrotestosterone, despite its relative inability to induce high level expression of MMTV.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	AR	ar	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	S49	S49	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dihydrotestosterone	dihydrotestosterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	despite	despite	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
25	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1059
# text = To investigate this further, we examined the steroid-regulated expression of an endogenous thymocyte-specific gene called GIG18.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	GIG18	GIG18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1060
# text = We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and, moreover, that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	GIG18	GIG18	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	rapidly	rapidly	ADV	RB	_	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	AR	be	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	AR	be	PROPN	NNP	Number=Sing	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	indeed	indeed	ADV	RB	_	_	_	_	_
22	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	S49	S49	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	GIG18	Gig18	NOUN	NN	Number=Sing	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
43	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
44	events	event	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1061
# text = Taken together, these results support our conclusion that transcriptional transactivation is a necessary signaling component of S49 cell apoptosis, although an additional role for GR-mediated transrepression cannot be excluded.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
8	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	component	component	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	S49	S49	NUM	CD	NumType=Card	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	although	although	SCONJ	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	mediated	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
30	transrepression	transrepression	NOUN	NN	Number=Sing	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
32	not	not	PART	RB	_	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	excluded	exclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1062
# text = Document 00300111 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300111	00300111	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1063
# text = Infection and replication of Tat- human immunodeficiency viruses: genetic analyses of LTR and tat mutations in primary and long-term human lymphoid cells.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
9	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
17	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	term	term	NOUN	NN	Number=Sing	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1064
# text = Tat is an essential regulatory protein for the replication of human immunodeficiency virus (HIV).
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1065
# text = Mutations in the tat gene have been shown to block HIV replication in human T cells.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1066
# text = Several studies have established that Tat releases an elongation block to the transcription of HIV long terminal repeat (LTR); however, it is not known whether this mechanism alone is sufficient to explain the block to HIV replication in human T cells when Tat is absent.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
7	releases	release	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	_
10	block	block	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	whether	whether	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
32	alone	alone	ADV	RB	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	block	block	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
41	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	when	when	ADV	WRB	PronType=Int	_	_	_	_
47	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1067
# text = It is possible that Tat is also needed for other functions during HIV replication.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1068
# text = To test these hypotheses, we studied several tat mutants, including two stop codon mutants and one deletion mutant using replication-competent HIV-1 constructs carrying wild-type or mutant LTRs with modifications in the NF-kappa B and/or Sp1 binding sites.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	hypotheses	hypothese	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
10	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	stop	stop	NOUN	NN	Number=Sing	_	_	_	_
15	codon	codon	NOUN	NN	Number=Sing	_	_	_	_
16	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	one	one	NUM	CD	NumType=Card	_	_	_	_
19	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
20	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	competent	competent	NOUN	NN	Number=Sing	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
29	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
30	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
35	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
45	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
46	or	or	CCONJ	CC	_	_	_	_	_
47	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
48	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1069
# text = In this study, we show that Tat- HIV-1 with wild-type LTRs can replicate in HeLa cells, and the virus produced from HeLa cells can infect primary peripheral blood lymphocytes and macrophages.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
32	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
33	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
34	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1070
# text = It was found that the propagation of the Tat mutants containing wild-type LTRs was less efficient than that of the LTR-modified Tat mutants.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	propagation	propagation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
10	mutants	mutant	PROPN	NNPS	Number=Plur	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	LTRs	LTR	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
18	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR-	ltr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1071
# text = Large amounts of viral RNA and particles were synthesized in infections established using the tat mutants that contain modified LTRs.
1	Large	large	ADJ	JJ	Degree=Pos	_	_	_	_
2	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
12	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
16	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1072
# text = However, this efficient propagation of the LTR-modified tat mutants was restricted to some lymphoid cell lines that have been transformed with other viruses.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
5	propagation	propagation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
11	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	viruses	virus	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1073
# text = Thus, despite its essential role for releasing an elongation block, Tat is not otherwise absolutely required for synthesis of full-length HIV transcripts and assembly of virus particles.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	despite	despite	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	releasing	release	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	_
11	block	block	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	otherwise	otherwise	ADV	RB	_	_	_	_	_
17	absolutely	absolutely	ADV	RB	_	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	length	length	NOUN	NN	Number=Sing	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
26	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	particles	particle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1074
# text = Direct sequencing of the viral genomes and reinfection kinetics showed no evidence of wild-type reversion even after prolonged infection with the Tat- virus.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	genomes	genome	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	reinfection	reinfection	NOUN	NN	Number=Sing	_	_	_	_
9	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	reversion	reversion	NOUN	NN	Number=Sing	_	_	_	_
18	even	even	ADV	RB	_	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1075
# text = The implications for in vivo HIV-1 replication and potential application of this system to the study of alternative Tat function are discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
12	application	application	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	study	study	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
21	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1076
# text = Document 00300112 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300112	00300112	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1077
# text = The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	prointerleukin	prointerleukin	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1078
# text = In these studies, we have identified DNA sequences and specific protein interactions necessary for transcriptional regulation of the human prointerleukin 1 beta (proIL-1 beta) gene.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	prointerleukin	prointerleukin	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1079
# text = A cell-type-independent lipopolysaccharide (LPS)-responsive enhancer element located between -3757 and -2729 bp upstream from the transcription start site (cap site) consisted of at least six discrete subregions which were essential to the maximal induction by LPS in transfected monocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	-3757	-3757	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	2729	2729	NUM	CD	NumType=Card	_	_	_	_
21	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
22	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	start	start	NOUN	NN	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	at	at	ADV	RB	_	_	_	_	_
35	least	least	ADV	RBS	Degree=Sup	_	_	_	_
36	six	six	NUM	CD	NumType=Card	_	_	_	_
37	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
38	subregions	subregion	NOUN	NNS	Number=Plur	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1080
# text = The enhancer also appeared to mediate phorbol myristate acetate induction in monocytes and IL-1 responsiveness in fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1081
# text = Deletion and base substitution mutations along with DNA binding studies demonstrated that the enhancer contained a minimum of three functional protein binding sequences, two of which appeared to be important for gene induction.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	base	base	NOUN	NN	Number=Sing	_	_	_	_
4	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
6	along	along	ADP	IN	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	minimum	minimum	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	three	three	NUM	CD	NumType=Card	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1082
# text = One of the essential proteins which bound to the enhancer was similar or identical to members of the C/EBP family of transcription factors required for both IL-1- and LPS-specific induction of the IL-6 gene (i.e., the NF-IL6 proteins).
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	6	6	NUM	CD	NumType=Card	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
50	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1083
# text = When ligated to the proIL-1 beta cap site-proximal region (located between -131 to +12), both the proIL-1 beta and the simian virus 40 enhancer elements functioned more efficiently in monocytes than in HeLa cells, which are not normally competent for IL-1 beta expression.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	ligated	ligate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	131	131	NUM	CD	NumType=Card	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	+12	+12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
33	40	40	NUM	CD	NumType=Card	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
35	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
36	functioned	function	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	more	more	ADV	RBR	_	_	_	_	_
38	efficiently	efficiently	ADV	RB	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
41	than	than	ADP	IN	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	which	which	PRON	WDT	PronType=Rel	_	_	_	_
47	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	normally	normally	ADV	RB	_	_	_	_	_
50	competent	competent	ADJ	JJ	Degree=Pos	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	1	1	NUM	CD	NumType=Card	_	_	_	_
55	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1084
# text = When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	ligated	ligate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
23	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
24	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
42	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
45	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1085
# text = Document 00300113 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300113	00300113	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1086
# text = Interaction of HTLV-I Tax with the human proteasome: implications for NF-kappa B induction.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1087
# text = The human T-cell leukemia virus type I (HTLV-I) has been etiologically associated with the development of the adult T-cell leukemia (ATL) as well as degenerative neurologic syndrome termed tropical spastic paraparesis (TSP).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	etiologically	etiologically	ADV	RB	_	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
24	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	ATL	ATL	INTJ	UH	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	degenerative	degenerative	ADJ	JJ	Degree=Pos	_	_	_	_
34	neurologic	neurologic	ADJ	JJ	Degree=Pos	_	_	_	_
35	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
36	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	tropical	tropical	ADJ	JJ	Degree=Pos	_	_	_	_
38	spastic	spastic	ADJ	JJ	Degree=Pos	_	_	_	_
39	paraparesis	paraparesis	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TSP	TSP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1088
# text = HTLV-I encodes a potent transactivator protein termed Tax that appears to play an important role in the process of T-cell immortalization.
1	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
9	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1089
# text = Even though the mechanisms by which Tax induces transformation are still unknown, it seems likely that the ability of Tax to alter the expression of many cellular genes plays an important part in this process.
1	Even	even	ADV	RB	_	_	_	_	_
2	though	though	SCONJ	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	DET	WDT	PronType=Int	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	still	still	ADV	RB	_	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
28	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
33	part	part	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
36	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1090
# text = Tax does not bind directly to DNA but rather deregulates the activity of cellular transcription factors.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
5	directly	directly	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	rather	rather	ADV	RB	_	_	_	_	_
10	deregulates	deregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1091
# text = One family of host transcription factors whose activity is altered by Tax includes NF-kappa B/Rel.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	host	host	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
13	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1092
# text = These transcription factors are post-transcriptionally regulated by their assembly with a second family of inhibitory proteins termed I kappa B that serve to sequester the NF-kappa B/Rel complexes in the cytoplasm.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	post	post	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	-transcriptionally	-transcriptionally	ADV	RB	_	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	sequester	sequester	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
33	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1093
# text = Upon cellular activation, I kappa B alpha is phosphorylated, polyubiquitinated, and degraded in the proteasome.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	polyubiquitinated	polyubiquitinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1094
# text = This proteolytic event liberates NF-kappa B, permitting its rapid translocation into the nucleus where it binds to its cognate enhancer elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	_
4	liberates	liberate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	permitting	permitt	VERB	VBG	VerbForm=Ger	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1095
# text = Similarly, the p105 precursor of the NF-kappa B p50 subunit is also post-translationally processed in the proteasome.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	post	post	X	AFX	_	_	_	_	SpaceAfter=No
17	-translationally	-translationally	ADV	RB	_	_	_	_	_
18	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1096
# text = The mechanisms by which Tax activates NF-kappa B remain unclear, and findings presented in the literature are often controversial.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
16	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	literature	literature	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	often	often	ADV	RB	_	_	_	_	_
22	controversial	controversial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1097
# text = We identified a physical interaction between Tax and the HsN3 subunit of the human proteasome.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HsN3	HsN3	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1098
# text = This raises the intriguing possibility that physical association of the HsN3 proteasome subunit with HTLV-I Tax coupled with the independent interaction of Tax with either p100 or p65-I kappa B alpha targets these cytoplasmic NF-kappa B/Rel complexes to the proteasome for processing.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	raises	rais	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	intriguing	intrigue	VERB	VBG	VerbForm=Ger	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
8	association	association	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HsN3	HsN3	NUM	CD	NumType=Card	_	_	_	_
12	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
19	coupled	couple	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	either	either	CCONJ	CC	_	_	_	_	_
28	p100	p100	NUM	CD	NumType=Card	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-I	-i	ADJ	JJ	Degree=Pos	_	_	_	_
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	alpha	alpha	ADP	IN	_	_	_	_	_
35	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
38	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
44	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_
49	processing	processing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1099
# text = Document 00300114 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300114	00300114	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1100
# text = X-rays-induced secretion of cellular factor(s) that enhance(s) HIV-1 promoter transcription in various non-irradiated transfected cell lines.
1	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	rays	ray	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	s	s	X	AFX	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
25	non-irradiated	non-irradiated	ADJ	JJ	Degree=Pos	_	_	_	_
26	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1101
# text = Various cellular stress agents like ionizing radiation exposure could activate human immunodeficiency virus type 1 (HIV- 1) replication or reporter gene expression.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
4	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
5	like	like	SCONJ	IN	_	_	_	_	_
6	ionizing	ionize	VERB	VBG	VerbForm=Ger	_	_	_	_
7	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1102
# text = In addition, extracellular factor(s) released by X-ray-treated human colonic carcinoma cell line (HT29) might activate the long terminal repeat (LTR) of HIV-1 in non-irradiated HT29 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	extracellular	extracelular	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	s	s	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ray	ray	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	colonic	colonic	NOUN	NN	Number=Sing	_	_	_	_
18	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HT29	HT29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
25	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	non-irradiated	non-irradiated	ADJ	JJ	Degree=Pos	_	_	_	_
39	HT29	HT29	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1103
# text = In the present report we show that in various transiently or stably transfected cell lines, X-ray irradiation up-regulates HIV-1 LTR transcription through the kappaB regulatory elements.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	transiently	transiently	ADV	RB	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	stably	stably	ADV	RB	_	_	_	_	_
13	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	X	x	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	ray	ray	NOUN	NN	Number=Sing	_	_	_	_
20	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
21	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1104
# text = A factor(s), which is processed by and acts upon a variety of cell types, was detected by addition to non-irradiated cells of either X-ray-treated cells or a conditioned medium taken from irradiated cultures.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	processed	process	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	non-irradiated	non-irradiate	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	either	either	CCONJ	CC	_	_	_	_	_
29	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	ray	ray	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
39	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	irradiated	irradiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1105
# text = The magnitude of responsiveness is cell type dependent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1106
# text = In addition, X-ray activation of HIV-1 LTR in transiently or stably transfected cell lines is inhibited by a potent antioxidant drug, pyrrolidine dithiocarbamate and by another drug, known for its role in the trapping of growth factors, suramin.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	ray	ray	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transiently	transiently	ADV	RB	_	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	stably	stably	ADV	RB	_	_	_	_	_
17	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
25	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
26	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	pyrrolidine	pyrrolidine	PRON	PRP	_	_	_	_	_
29	dithiocarbamate	dithiocarbamate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	another	another	DET	DT	_	_	_	_	_
33	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	role	role	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	trapping	trapping	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	suramin	suramin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1107
# text = The importance of these observations in the pathophysiology of patients with AIDS-related cancers treated by radiotherapy remains to be established.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	radiotherapy	radiotherapy	NOUN	NN	Number=Sing	_	_	_	_
19	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1108
# text = Document 00300115 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300115	00300115	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1109
# text = TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
1	TRAMP	TRAMP	SYM	NFP	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediating	mediating	VERB	VBG	VerbForm=Ger	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	Apo-1/CD95	Apo-1/CD95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1110
# text = A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	member	member	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TRAMP	Tramp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1111
# text = The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
3	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	393	393	NUM	CD	NumType=Card	_	_	_	_
7	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
8	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	long	long	ADV	RB	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	TRAMP	Tramp	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	most	most	ADV	RBS	_	_	_	_	_
14	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1112
# text = TRAMP is abundantly expressed on thymocytes and lymphocytes.
1	TRAMP	Tramp	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	abundantly	abundantly	ADV	RB	_	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1113
# text = Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
2	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	four	four	NUM	CD	NumType=Card	_	_	_	_
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
25	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1114
# text = Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TRAMP	TRAMP	NOUN	NN	Number=Sing	_	_	_	_
4	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1115
# text = TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2.
1	TRAMP	TRAMp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ICE	ice	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	like	like	ADP	IN	_	_	_	_	_
15	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1116
# text = In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TRAMP	TRAMP	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	any	any	DET	DT	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1117
# text = Document 00300116 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300116	00300116	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1118
# text = Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes.
1	Interactions	Interaction	NOUN	NNS	Number=Plur	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	class	class	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1119
# text = Class II major histocompatibility (class II) genes are regulated in a B-cell-specific and gamma interferon-inducible fashion.
1	Class	class	NOUN	NN	Number=Sing	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
4	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1120
# text = The master switch for the expression of these genes is the class II transactivator (CIITA).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	master	master	NOUN	NN	Number=Sing	_	_	_	_
3	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1121
# text = In this report, we demonstrate that one of the functions of CIITA is to recruit the CREB binding protein (CBP) to class II promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	recruit	recruit	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	class	class	VERB	VB	VerbForm=Inf	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1122
# text = Not only functional but also specific binding interactions between CIITA and CBP were demonstrated.
1	Not	not	ADV	RB	_	_	_	_	_
2	only	only	ADV	RB	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1123
# text = Moreover, a dominant negative form of CBP decreased the activity of class II promoters and levels of class II determinants on the surface of cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
9	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	class	class	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1124
# text = Finally, the inhibition of class II gene expression by the glucocorticoid hormone could be attributed to the squelching of CBP by the glucocorticoid receptor.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	squelching	squelching	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1125
# text = We conclude that CBP, a histone acetyltransferase, plays an important role in the transcription of class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	CBP	CBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
8	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1126
# text = Document 00300117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300117	00300117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1127
# text = A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p [see comments]
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
3	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
4	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	Rpd3	Rpd3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	p	p	NOUN	NN	Number=Sing	_	_	_	_
13	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1128
# text = Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle.
1	Trapoxin	Trapoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	microbially	microbially	ADV	RB	_	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cyclotetrapeptide	cyclotetrapeptide	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
10	deacetylation	deacetylation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	arrest	arrest	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1129
# text = A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	trapoxin	trapoxin	NOUN	NN	Number=Sing	_	_	_	_
3	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
4	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	copurified	copurify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
16	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1130
# text = Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library.
1	Both	both	DET	DT	_	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
7	microsequencing	microsequencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
16	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
17	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HD1	Hd1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1131
# text = As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.
1	As	as	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	very	very	ADV	RB	_	_	_	_	_
7	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
13	Rpd3	Rpd3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
23	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1132
# text = Document 00300118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300118	00300118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1133
# text = BCL-6 expression during B-cell activation.
1	BCL	Bcl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1134
# text = Translocations involving the BCL-6 gene are common in the diffuse large cell subtype of non-Hodgkin's lymphoma.
1	Translocations	Translocation	NOUN	NNS	Number=Plur	_	_	_	_
2	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	diffuse	diffuse	NOUN	NN	Number=Sing	_	_	_	_
13	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	subtype	subtype	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	non-Hodgkin	non-Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	's	's	PART	POS	_	_	_	_	_
19	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1135
# text = Invariably, the BCL-6 coding region is intact, but its 5' untranslated region is replaced with sequences from the translocation partner.
1	Invariably	Invariably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
14	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	_
17	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
26	partner	partner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1136
# text = The present study shows that BCL-6 expression is regulated in lymphocytes during mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	BCL	Bcl	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1137
# text = Resting B and T lymphocytes contain high levels of BCL-6 mRNA.
1	Resting	rest	PROPN	NNP	Number=Sing	_	_	_	_
2	B	b	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	mRNA.	mRNA.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1138
# text = Stimulation of mouse B cells with anti-IgM or IgD antibodies, bacterial lipopolysaccharide, phorbol 12-myristate 13-acetate plus ionomycin, or CD40 ligand led to a five-fold to 35-fold decrease in BCL-6 mRNA levels.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	anti-IgM	anti-Igm	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IgD	igd	NOUN	NN	Number=Sing	_	_	_	_
10	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	plus	plus	CCONJ	CC	_	_	_	_	_
23	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
27	ligand	ligand	PROPN	NNP	Number=Sing	_	_	_	_
28	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	five	five	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
38	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
44	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1139
# text = Similar downregulation of BCL-6 mRNA was seen in human B cells stimulated with Staphylococcus aureus plus interleukin-2 or anti-IgM antibodies and in human T lymphocytes stimulated with phytohemagglutinin.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	Staphylococcus	Staphylococcus	PROPN	NNP	Number=Sing	_	_	_	_
17	aureus	aureus	NOUN	NN	Number=Sing	_	_	_	_
18	plus	plus	CCONJ	CC	_	_	_	_	_
19	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	anti-IgM	anti-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
24	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1140
# text = BCL-6 mRNA levels began to decrease 8 to 16 hours after stimulation, before cells entered S phase.
1	BCL	Bcl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	began	begin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	16	16	NUM	CD	NumType=Card	_	_	_	_
12	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	before	before	SCONJ	IN	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	entered	enter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	S	s	PROPN	NNP	Number=Sing	_	_	_	_
20	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1141
# text = Although polyclonal activation of B cells in vitro invariably decreased BCL-6 MRNA expression, activated B cells from human germinal centers expressed BCL-6 mRNA at levels comparable to the levels in resting B cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
9	invariably	invariably	ADV	RB	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	MRNA	MRNa	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
23	centers	center	NOUN	NNS	Number=Plur	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	6	6	NUM	CD	NumType=Card	_	_	_	_
28	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	SCONJ	IN	_	_	_	_	_
36	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1142
# text = Despite these similar mRNA levels, BCL-6 protein expression was threefold to 34-fold higher in germinal center B cells than in resting B cells, suggesting that BCL-6 protein levels are controlled by translational or posttranslational mechanisms.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	threefold	threefold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	34	34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
21	center	center	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	in	in	SCONJ	IN	_	_	_	_	_
26	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
43	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1143
# text = These observations suggest that the germinal center reaction provides unique activation signals to B cells that allow for continued, high-level BCL-6 expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
7	center	center	NOUN	NN	Number=Sing	_	_	_	_
8	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
9	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	allow	allow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	continued	continue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	BCL	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1144
# text = Document 00300119 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300119	00300119	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1145
# text = Involvement of an SAF-like transcription factor in the activation of serum amyloid A gene in monocyte/macrophage cells by lipopolysaccharide.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	SAF	SAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
14	amyloid	amyloid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1146
# text = Serum amyloid A (SAA) has been linked to atherosclerosis because of its ability to remodel high-density lipoprotein by the depletion of apolipoprotein A1, its ability to bind cholesterol, and its presence in the atherosclerotic plaques of coronary and carotid arteries.
1	Serum	Serum	NOUN	NN	Number=Sing	_	_	_	_
2	amyloid	amyloid	NOUN	NN	Number=Sing	_	_	_	_
3	A	a	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SAA	SAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	because	because	ADP	IN	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	remodel	remodel	VERB	VB	VerbForm=Inf	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	density	density	NOUN	NN	Number=Sing	_	_	_	_
21	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	apolipoprotein	apolipoprotein	NOUN	NN	Number=Sing	_	_	_	_
27	A1	A1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
33	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
37	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
42	plaques	plaque	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	coronary	coronary	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	carotid	carotid	NOUN	NN	Number=Sing	_	_	_	_
47	arteries	artery	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1147
# text = In the present study, we investigated the induction mechanism of SAA gene in THP-1 monocyte/macrophage cells which play a critical role in the development of atherosclerotic fatty streak and plaque formation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	SAA	SAA	PROPN	NNP	Number=Sing	_	_	_	_
13	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
32	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
33	streak	streak	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
36	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1148
# text = We and others have shown that SAA gene is induced in monocyte/macrophage cells by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	SAA	SAa	PROPN	NNP	Number=Sing	_	_	_	_
8	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1149
# text = By promoter function analysis, we show that the SAA promoter sequence between -280 and -226 can confer LPS responsiveness.
1	By	by	ADP	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	SAA	SAA	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	280	280	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	226	226	NUM	CD	NumType=Card	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
22	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1150
# text = Gel electrophoretic mobility shift assay detected an induced DNA-binding activity in these cells in response to LPS.
1	Gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1151
# text = Characterization of the DNA-binding protein by UV cross-linking, Southwestern blot, and antibody ablation/supershift assays revealed that it is similar to a recently reported nuclear factor designated SAF.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
10	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
14	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
18	ablation	ablation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
22	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	recently	recently	ADV	RB	_	_	_	_	_
30	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	SAF	SAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1152
# text = These results demonstrated that LPS-mediated SAA gene induction in monocyte/macrophage cells is primarily due to the induction of SAF activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	SAA	SAa	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	primarily	primarily	ADV	RB	_	_	_	_	_
18	due	due	ADP	IN	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	SAF	SAF	PROPN	NNP	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1153
# text = Document 00300120 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300120	00300120	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1154
# text = The spatial distribution of human immunoglobulin genes within the nucleus:
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	spatial	spatial	ADJ	JJ	Degree=Pos	_	_	_	_
3	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1155
# text = evidence for gene topography independent of cell type and transcriptional activity.
1	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
4	topography	topography	NOUN	NN	Number=Sing	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1156
# text = The three-dimensional positioning of immunoglobulin
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dimensional	dimensional	ADJ	JJ	Degree=Pos	_	_	_	_
5	positioning	positioning	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1157
# text = (Ig) genes within the nucleus of human cells was investigated using in situ hybridization and confocal microscopy.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
16	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
19	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1158
# text = The visualization of heavy and light chain genes in B-lymphoid cells showed that the three
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	visualization	visualization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	light	light	ADJ	JJ	Degree=Pos	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	three	three	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 1159
# text = Ig genes are differentially and nonrandomly distributed in different nuclear subvolumes: the kappa genes were found to be preferentially confined to an outer nuclear volume, whereas the gamma and lambda genes consistently occupied more central positions within the nucleus, the lambda genes being more interior when compared with the gamma genes.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	differentially	differentially	ADV	RB	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	nonrandomly	nonrandomly	ADV	RB	_	_	_	_	_
7	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	subvolumes	subvolume	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	preferentially	preferentially	ADV	RB	_	_	_	_	_
21	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	outer	outer	ADJ	JJ	Degree=Pos	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	volume	volume	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
34	consistently	consistently	ADV	RB	_	_	_	_	_
35	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	more	more	ADV	RBR	_	_	_	_	_
37	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
38	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
39	within	within	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
45	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
46	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
47	more	more	ADV	RBR	_	_	_	_	_
48	interior	interior	ADJ	JJ	Degree=Pos	_	_	_	_
49	when	when	ADV	WRB	PronType=Int	_	_	_	_
50	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1160
# text = The data further show that these overall topographical distributions are independent of gene transcriptional activity and are conserved in different cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
8	topographical	topographical	ADJ	JJ	Degree=Pos	_	_	_	_
9	distributions	distribution	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	PRON	NN	Number=Sing	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1161
# text = Although subtle gene movements within those defined topographical regions cannot be excluded by this study, the results indicate that tissue specificity of gene expression is not accompanied by drastic changes in gene nuclear topography, rather suggesting that gene organization within the nucleus may be primarily dependent on structural constraints imposed on the respective chromosomes.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	movements	movement	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	topographical	topographical	ADJ	JJ	Degree=Pos	_	_	_	_
9	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
11	not	not	PART	RB	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	excluded	exclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
23	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	drastic	drastic	ADJ	JJ	Degree=Pos	_	_	_	_
32	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
35	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	topography	topography	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	rather	rather	ADV	RB	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
42	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
43	within	within	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
46	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
47	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
48	primarily	primarily	ADV	RB	_	_	_	_	_
49	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
52	constraints	constraint	NOUN	NNS	Number=Plur	_	_	_	_
53	imposed	impose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	on	on	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
57	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1162
# text = Document 00300121 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300121	00300121	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1163
# text = V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth [published erratum appears in AIDS Res Hum Retroviruses 1997 May 1;13(7):633]
1	V3	V3	NUM	CD	NumType=Card	_	_	_	_
2	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
10	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
23	Res	res	NOUN	NNS	Number=Plur	_	_	_	_
24	Hum	Hum	PROPN	NNP	Number=Sing	_	_	_	_
25	Retroviruses	Retroviruse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	1997	1997	NUM	CD	NumType=Card	_	_	_	_
27	May	May	PROPN	NNP	Number=Sing	_	_	_	_
28	1;13	1;13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	:633	:633	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1164
# text = We tested the effect of three linear or two loop peptides derived from the V3 region of the HTLV-III BH10 clone or the SF2 strain of human immunodeficiency virus type 1 on IL-2-driven T cell proliferation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	three	three	NUM	CD	NumType=Card	_	_	_	_
7	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	loop	loop	ADJ	JJ	Degree=Pos	_	_	_	_
11	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
12	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	V3	V3	NUM	CD	NumType=Card	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	III	iii	NUM	CD	NumType=Card	_	_	_	_
22	BH10	BH10	NUM	CD	NumType=Card	_	_	_	_
23	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	SF2	Sf2	NOUN	NN	Number=Sing	_	_	_	_
27	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
31	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1165
# text = V3-BH10, which consists of 42 amino acids and has a loop structure, suppressed IL-2-driven proliferation of all IL-2-dependent cells [Kit225, ED-40515(+), KT-3, 7-day PHA-blasts, and fresh peripheral blood mononuclear cells] tested, whereas it did not suppress the cell growth of IL-2-independent cell lines (Hut102, Molt-4, and Jurkat).
1	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-BH10	-BH10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	42	42	NUM	CD	NumType=Card	_	_	_	_
8	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
9	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	all	all	DET	DT	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Kit	Kit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	225	225	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	ED-40515	ED-40515	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	(+)	(+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	KT	KT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	day	day	NOUN	NN	Number=Sing	_	_	_	_
44	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
50	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
51	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
52	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	]	]	PUNCT	-RRB-	_	_	_	_	_
55	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	whereas	whereas	SCONJ	IN	_	_	_	_	_
58	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
59	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
60	not	not	PART	RB	_	_	_	_	_
61	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
64	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
71	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
72	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
73	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
74	Hut	Hut	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	102	102	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	Molt	Molt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
79	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	,	,	PUNCT	,	_	_	_	_	_
81	and	and	CCONJ	CC	_	_	_	_	_
82	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
83	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
84	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1166
# text = This suppressive effect was also seen in IL-2-driven cell growth of CD8-positive lymphocytes purified from 7-day PHA-blasts, indicating that CD4 molecules were not required for the suppression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	day	day	NOUN	NN	Number=Sing	_	_	_	_
25	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
32	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1167
# text = The treatment with anti-V3 loop monoclonal antibody (902 antibody) completely abolished the suppressive effect of V3-BH10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
5	-V3	-V3	NUM	CD	NumType=Card	_	_	_	_
6	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
7	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	902	902	NUM	CD	NumType=Card	_	_	_	_
11	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	V3-	v3-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	BH10	BH10	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1168
# text = In addition, V3-BH10 generated the arrest of Kit225 cells and also purified CD8-positive lymphocytes in G1 phase in the presence of IL-2.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	BH	Bh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Kit225	Kit225	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	G1	g1	PROPN	NNP	Number=Sing	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1169
# text = Neither chromatin condensation nor DNA fragmentation was detected in Kit225 cells cultured with V3-BH10 and IL-2.
1	Neither	neither	DET	DT	_	_	_	_	_
2	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
3	condensation	condensation	NOUN	NN	Number=Sing	_	_	_	_
4	nor	nor	CCONJ	CC	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Kit	Kit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	225	225	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	V3-	v3-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	BH10	BH10	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1170
# text = V3-BH10 neither blocked radiolabeled IL-2 binding to IL-2 receptors nor affected tyrosyl phosphorylation of several cellular proteins (p120, p98, p96, p54, and p38), which is immediately induced by IL-2 stimulation.
1	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	BH	Bh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	neither	neither	NOUN	NN	Number=Sing	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	radiolabeled	radiolabel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	tyrosyl	tyrosyl	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
23	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	p120	p120	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	p98	p98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	p96	p96	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	p54	p54	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	p38	p38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	immediately	immediately	ADV	RB	_	_	_	_	_
41	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1171
# text = However, V3-BH10 enhanced IL-2-induced mRNA expression of c-fos but not c-myc or junB.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	BH	Bh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	junB	junb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1172
# text = Thus, the binding of V3 loop of gp120 to the cell surface molecule(s) appears to affect intracellular IL-2 signaling, which leads to the suppression of IL-2-induced T cell growth.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	V3	V3	NUM	CD	NumType=Card	_	_	_	_
7	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	gp120	gp120	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	s	s	X	AFX	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
21	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1173
# text = Document 00300122 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300122	00300122	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1174
# text = Interleukin 6-induced differentiation of a human B cell line into IgM-secreting plasma cells is mediated by c-fos.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	IgM	Igm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	secreting	secreting	ADJ	JJ	Degree=Pos	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1175
# text = The role of the protooncogene c-fos in interleukin (IL) 6-induced B cell differentiation was assessed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
6	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1176
# text = Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	SKW	SKW	PROPN	NNP	Number=Sing	_	_	_	_
4	6.4	6.4	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
19	sense	sense	NOUN	NN	Number=Sing	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1177
# text = The effect appeared within 30 min and returned to basal levels after 2 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	30	30	NUM	CD	NumType=Card	_	_	_	_
6	min	min	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	returned	return	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1178
# text = The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
5	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IgM	Igm	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	SKW	SKW	PROPN	NNP	Number=Sing	_	_	_	_
20	6.4	6.4	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	p	p	NOUN	NN	Number=Sing	_	_	_	_
24	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	whereas	whereas	SCONJ	IN	_	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
32	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1179
# text = These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	_
14	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	SKW	SKW	PROPN	NNP	Number=Sing	_	_	_	_
20	6.4	6.4	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	IgM	Igm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	secreting	secreting	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1180
# text = Document 00300123 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300123	00300123	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1181
# text = Tissue-specific expression of the platelet GPIIb gene.
1	Tissue	Tissue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
8	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1182
# text = One of the major objectives in the study of thrombogenesis is to determine the mechanisms by which a hematopoietic progenitor is activated and committed to the megakaryocytic lineage.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	objectives	objective	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	study	study	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thrombogenesis	thrombogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	which	which	DET	WDT	PronType=Int	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	committed	committed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1183
# text = Recent development of primary cultures of human megakaryocytes and the molecular cloning of genes that are specific to this lineage offer the possibility of getting some insights into the genetic mechanisms that control megakaryocytopoiesis.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
12	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	offer	offer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	SCONJ	IN	_	_	_	_	_
25	getting	get	VERB	VBG	VerbForm=Ger	_	_	_	_
26	some	some	DET	DT	_	_	_	_	_
27	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	megakaryocytopoiesis	megakaryocytopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1184
# text = One gene of interest is the glycoprotein IIb (GPIIb) gene; GPIIb, the alpha subunit of the platelet cytoadhesin GPIIb-IIIa, is produced in megakaryocytes at an early stage of the differentiation, whereas the other subunit of this complex, GPIIIa, is expressed in other cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interest	interest	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
8	IIb	IIb	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
22	cytoadhesin	cytoadhesin	ADP	IN	_	_	_	_	_
23	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	IIIa	IIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
34	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	whereas	whereas	SCONJ	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
42	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
45	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	GPIIIa	GPIIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1185
# text = For these reasons, the 5'-flanking region of the GPIIb gene was used to identify the regions that interact with DNA-binding nuclear factors.
1	For	for	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	reasons	reason	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1186
# text = A fragment extending from -643 to +33 is capable of controlling the tissue-specific expression of the CAT gene in transfection experiments.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
3	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	643	643	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	+33	+33	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	SCONJ	IN	_	_	_	_	_
12	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
24	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1187
# text = Within this region, we have identified several sequences that are implicated in DNA protein interactions as shown in DNAse I footprints and gel mobility shift assays.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	DNAse	DNAse	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1188
# text = One region, centered at -54, is similar to a nuclear factor E1-binding site, and a region located at position -233 contains a CCAAT motif.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	54	54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	E1	e1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	position	position	NOUN	NN	Number=Sing	_	_	_	_
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	233	233	NUM	CD	NumType=Card	_	_	_	_
28	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
31	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1189
# text = Two domains centered at positions -345 and -540, respectively, bind proteins that are present in megakaryocytic cells and nonrelated cells as well.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
3	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	345	345	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	540	540	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	bind	bind	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	nonrelated	nonrelate	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1190
# text = Finally, two other domains, located at positions -460 and -510, interact with proteins that are only present in megakaryocytic cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	460	460	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	510	510	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1191
# text = In addition, deletion of the region containing these two domains results in a significant decrease of the promoter activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
12	results	result	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1192
# text = It is very likely that these domains bind megakaryocyte-specific nuclear proteins acting as positive transcription factors.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	very	very	ADV	RB	_	_	_	_	_
4	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
8	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	megakaryocyte	megakaryocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1193
# text = Document 00300124 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300124	00300124	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1194
# text = HIV-1
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 1195
# text = Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1196
# text = The human immunodeficiency virus type 1 long terminal repeat, HIV-1-LTR, contains binding sites for several cellular transcription factors which contribute to HIV-1 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1197
# text = Our previous studies on the function of the HIV-1-encoded Nef protein suggested that Nef may be an inhibitor HIV-1 transcription.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
15	protein	protein	PROPN	NNP	Number=Sing	_	_	_	_
16	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	inhibitor	inhibitor	ADJ	JJ	Degree=Pos	_	_	_	_
23	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1198
# text = To determine whether Nef affects the binding of cellular factors implicated in HIV-1 regulation, 32P-labeled oligonucleotides corresponding to the binding sites were incubated with nuclear extracts prepared from Nef-expressing T-cell lines that were not stimulated or were stimulated with T-cell mitogens.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
5	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	32P	32p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
22	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
32	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
37	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
40	that	that	PRON	WDT	PronType=Rel	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	not	not	PART	RB	_	_	_	_	_
43	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1199
# text = We found that Nef inhibited the recruitment of AP-1 DNA-binding activity in mitogen-stimulated human T-cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1200
# text = Additionally,
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 1201
# text = Nef expressing cells were transiently transfected with a plasmid in which HIV-1 AP-1 DNA recognition sequences were cloned downstream of the chloramphenicol acetyltransferase (CAT) gene.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	expressing	expressing	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	transiently	transiently	ADV	RB	_	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
20	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
27	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1202
# text = Mitogen-mediated transcriptional activation of the CAT gene in this construct was inhibited in Nef-expressing cells but not in control cells.
1	Mitogen	Mitogen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1203
# text = These studies suggest that, by inhibiting AP-1 activation, Nef may play a role in regulating HIV-1 gene expression in infected T-cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	inhibiting	inhibiting	VERB	VBG	VerbForm=Ger	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1204
# text = Document 00300125 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300125	00300125	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1205
# text = Synergism between two distinct elements of the HTLV-I enhancer during activation by the trans-activator of HTLV-I.
1	Synergism	Synergism	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1206
# text = We have conducted functional studies of the enhancer elements of human T-cell leukemia virus type I (HTLV-I) using the human T-cell lines Jurkat and MOLT 4, which are negative for HTLV-I, and MT-2 and TL-Mor, which carry the proviral genome of HTLV-I.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	MOLT	MOLT	PROPN	NNP	Number=Sing	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	MT	Mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	TL	Tl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	Mor	Mor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	which	which	PRON	WDT	PronType=Rel	_	_	_	_
52	carry	carry	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
55	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1207
# text = Two distinct elements have been implicated in function of the HTLV-I enhancer.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1208
# text = One is the 21-base-pair (bp) core element that is responsible for trans-activation by the HTLV-I trans-activator p40tax and that has the ability to bind to cyclic-AMP responsive element binding factor (CREB)-like factor(s).
1	One	one	PRON	PRP	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	core	core	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
28	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
40	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	_
42	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	like	like	ADP	IN	_	_	_	_	_
49	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	s	s	X	AFX	_	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1209
# text = The other is a region interposed between the 21-bp elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	interposed	interpose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1210
# text = In this study we demonstrate that a subfragment (C26) in the region between the 21-bp elements is involved in trans-activation by p40tax, possibly through binding to an NF-kappa B-like nuclear factor or factors.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	subfragment	subfragment	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	C26	c26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	trans-activation	trans-activation	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	possibly	possibly	ADV	RB	_	_	_	_	_
29	through	through	SCONJ	IN	_	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	like	like	ADP	IN	_	_	_	_	_
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1211
# text = Formation of the protein-DNA complex with the C26 subfragment was positively affected by p40tax.
1	Formation	Formation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	C26	c26	NOUN	NN	Number=Sing	_	_	_	_
11	subfragment	subfragment	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	positively	positively	ADV	RB	_	_	_	_	_
14	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1212
# text = The C26 element conferred partial responsiveness to p40tax when linked to one copy of the 21-bp element that, by itself, showed little activation in response to p40tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C26	c26	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
6	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	p40tax	p40tax	VERB	VB	VerbForm=Inf	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1213
# text = However, the C26 element alone, even when repeated, could not be activated by p40tax, unlike other NF-kappa B-binding elements.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	C26	c26	PROPN	NNP	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	even	even	ADV	RB	_	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	repeated	repeate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	unlike	unlike	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1214
# text = In contrast, the C26 element itself was profoundly activated upon stimulation with 12-O-tetradecanoylphorbol-13-acetate.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	C26	c26	PROPN	NNP	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	profoundly	profoundly	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1215
# text = These findings therefore suggest that the HTLV-I enhancer contains multiple functional elements, including binding sites for at least CREB- and NF-kappa B-like factors, which synergistically cooperate in activation of the HTLV-I enhancer in response to p40tax.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	like	like	ADP	IN	_	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	synergistically	synergistically	ADV	RB	_	_	_	_	_
35	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
43	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	response	response	NOUN	NN	Number=Sing	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1216
# text = Our results also demonstrate that TPA-dependent activation of the HTLV-I enhancer may be mediated through the C26 element.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	C26	c26	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1217
# text = Document 00300126 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300126	00300126	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1218
# text = Regulation of sialoadhesin expression on rat macrophages.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1219
# text = Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1220
# text = Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.
1	Sialoadhesin	Sialoadhesin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	member	member	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
11	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1221
# text = It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	subpopulation	subpopulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
21	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1222
# text = We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
19	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	freshly	freshly	ADV	RB	_	_	_	_	_
23	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
25	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
29	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	R2	r2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1223
# text = The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	sialoadhesin	sialoadhesin	ADP	IN	_	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	themselves	themself	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
31	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1224
# text = Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.
1	Sialoadhesin	Sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	RBCs	RBC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1225
# text = Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	predominantly	predominantly	ADV	RB	_	_	_	_	_
8	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1226
# text = Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
12	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
35	more	more	ADV	RBR	_	_	_	_	_
36	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
37	than	than	ADP	IN	_	_	_	_	_
38	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1227
# text = Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	reproduced	reproduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	priming	priming	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1228
# text = The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	mineralocorticoid	mineralocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1229
# text = Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
11	gland	gland	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
18	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
22	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1230
# text = This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
6	act	act	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1231
# text = Document 00300127 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300127	00300127	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1232
# text = Transcription factor activation in lymphokine activated killer cells and lymphocytes from patients receiving IL-2 immunotherapy.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	receiving	receive	VERB	VBG	VerbForm=Ger	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1233
# text = Administration of the cytokine interleukin-2 (IL-2) can result in therapeutic benefits for individuals with renal cell carcinoma and melanoma.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
17	benefits	benefit	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1234
# text = Here we report an analysis of the transcription factor families AP-1, Sp1, NF-kappaB, and signal transducers and activators of transcription (STAT) in cancer patients' lymphocytes before and after IL-2 immunotherapy, as assessed by a gel-shift assay.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	families	family	NOUN	NNS	Number=Plur	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Sp1	Sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
23	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
33	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	'	's	PUNCT	''	_	_	_	_	_
35	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	before	before	ADP	IN	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	after	after	ADP	IN	_	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	as	as	SCONJ	IN	_	_	_	_	_
45	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
51	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1235
# text = An in vitro surrogate of IL-2 immunotherapy is the incubation of fresh peripheral blood mononuclear cells (PBMC) from healthy individuals in IL-2 for several days, resulting in the production of lymphokine-activated killer (LAK) activity in these cultures.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
4	surrogate	surrogate	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
31	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	LAK	LAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1236
# text = One purpose of this study was to describe the profile of transcription factor activation in these different populations, and assess whether the patterns observed correlated with functional differences in these cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	assess	assess	NOUN	NN	Number=Sing	_	_	_	_
22	whether	whether	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
25	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
29	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1237
# text = Prior to in vivo IL-2 administration, the typical binding pattern of transcription factors in PBMC from patients resembled that seen in fresh PBMC from healthy individuals.
1	Prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	administration	administration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	resembled	resemble	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
26	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
29	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1238
# text = Over a 3-week course of IL-2 therapy, in most patients the binding patterns of AP-1 , Sp1, and NF-kappaB proteins changed to resemble those seen in PBMC activated by IL-2 in vitro.
1	Over	over	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	week	week	NOUN	NN	Number=Sing	_	_	_	_
6	course	course	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	,	,	PUNCT	,	_	_	_	_	_
24	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	changed	chang	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	resemble	resemble	VERB	VB	VerbForm=Inf	_	_	_	_
34	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1239
# text = However, the cells obtained from IL-2-treated patients did not have low-level constitutive expression of STAT binding factors as did LAK cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	STAT	Stat	SCONJ	IN	_	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	LAK	LAK	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1240
# text = When these patient cells were further stimulated by IL-2 in vitro, additional differences in STAT induction patterns were noted.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	further	further	ADV	RB	_	_	_	_	_
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
16	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1241
# text = These data provide further information on the molecular events occurring in immune cells generated through in vivo and in vitro administration of IL-2, and further document that there is not a precise congruence between PBMC activated in vivo and in vitro by IL-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
5	information	information	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
21	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
29	document	document	NOUN	NN	Number=Sing	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	there	there	PRON	EX	_	_	_	_	_
32	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
36	congruence	congruence	NOUN	NN	Number=Sing	_	_	_	_
37	between	between	ADP	IN	_	_	_	_	_
38	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
39	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1242
# text = Document 00300128 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300128	00300128	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1243
# text = A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
5	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	exclusively	exclusively	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	myelo	myelo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	processes	process	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1244
# text = B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	impair	impair	VERB	VB	VerbForm=Inf	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1245
# text = Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	limiting	limite	VERB	VBG	VerbForm=Ger	_	_	_	_
11	dilution	dilution	NOUN	NN	Number=Sing	_	_	_	_
12	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	strikingly	strikingly	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1246
# text = "Plus" clones replicated the virus efficiently, whereas "minus" clones did not.
1	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
2	Plus	plus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	"	"	PUNCT	''	_	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	replicated	replicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	efficiently	efficiently	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	whereas	whereas	SCONJ	IN	_	_	_	_	_
11	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
12	minus	minus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	"	"	PUNCT	''	_	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
15	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1247
# text = We examined these clones for differences in nuclear factor (NF)-kappa B activity which might account for the observed phenomenon.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
23	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1248
# text = Stimulation of plus clones liberated the classical p50-p65 complex from cytoplasmic pools, whereas minus clones produced an apparently novel, faster-migrating complex, as judged by electrophoretic mobility shift assays.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	plus	plus	CCONJ	CC	_	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	liberated	liberate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
8	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	pools	pool	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	wherea	SCONJ	IN	_	_	_	_	_
17	minus	minus	ADJ	JJ	Degree=Pos	_	_	_	_
18	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
19	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	apparently	apparently	ADV	RB	_	_	_	_	_
22	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
33	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
34	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
35	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1249
# text = It is surprising that the faster-migrating complex was composed also of p50 and p65.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	surprising	surprising	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1250
# text = However, the p65 subunit was COOH-terminally truncated, as shown by immunoprecipitation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	COOH	COOH	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	terminally	terminally	ADV	RB	_	_	_	_	_
10	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1251
# text = The truncation resulted from limited proteolysis of p65 during cellular extraction which released particular lysosomal serine proteases, such as elastase, cathepsin G, and proteinase 3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
3	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
6	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p65	p65	NUM	CD	NumType=Card	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	extraction	extraction	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
15	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
17	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	cathepsin	cathepsin	NOUN	NN	Number=Sing	_	_	_	_
24	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	proteinase	proteinase	NOUN	NN	Number=Sing	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1252
# text = These specific proteases are coordinately expressed and were present exclusively in the minus U937 clones, but not in the plus clones, as demonstrated in the case of cathepsin G.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	coordinately	coordinately	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	exclusively	exclusively	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	minus	minus	ADJ	JJ	Degree=Pos	_	_	_	_
14	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
15	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	plus	plus	ADJ	JJ	Degree=Pos	_	_	_	_
22	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	case	case	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cathepsin	cathepsin	NOUN	NN	Number=Sing	_	_	_	_
31	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1253
# text = In addition, these proteases were detected in certain subclones of THP-1 and HL-60 cells and in primary monocytes, in each case correlating with the truncated from of p65.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
10	subclones	subclone	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	60	60	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	each	each	DET	DT	_	_	_	_	_
27	case	case	NOUN	NN	Number=Sing	_	_	_	_
28	correlating	correlat	VERB	VBG	VerbForm=Ger	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1254
# text = We demonstrate in vitro cleavage of p65 by purified elastase and cathepsin G.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p65	p65	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	cathepsin	cathepsin	NOUN	NN	Number=Sing	_	_	_	_
13	G	g	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1255
# text = It is possible that particular serine proteases may have inhibiting effects on the replication of HIV-1 in myelo-monocytic cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
6	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
7	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
10	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	myelo	myelo	X	AFX	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1256
# text = The data also demonstrate that special precautions must be taken when making extracts from myelo-monocytic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	special	special	ADJ	JJ	Degree=Pos	_	_	_	_
7	precautions	precaution	NOUN	NNS	Number=Plur	_	_	_	_
8	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	taken	take	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	myelo	myelo	X	AFX	_	_	_	_	SpaceAfter=No
16	-monocytic	-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1257
# text = Document 00300129 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300129	00300129	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1258
# text = Nuclear factor-kappaB activation in human monocytes stimulated with lipopolysaccharide is inhibited by fibroblast conditioned medium and exogenous PGE2.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	fibroblast	fibroblast	ADV	RB	_	_	_	_	_
15	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
19	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1259
# text = The nuclear factor kappaB (NF-kappaB) is thought to be crucially involved in the gene activation of several cytokines, including tumor necrosis factor alpha (TNF).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	crucially	crucially	ADV	RB	_	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1260
# text = Previously, we showed that fibroblast conditioned medium (FCM) is able to inhibit both TNF mRNA accumulation and protein release in peripheral blood-derived human monocytes (PBM) stimulated with lipopolysaccharide (LPS).
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	fibroblast	fibroblast	ADV	RB	_	_	_	_	_
7	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	release	release	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PBM	PBM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1261
# text = In this study we have investigated the effect of FCM on the LPS-induced DNA-binding activity of NF-kappaB, by means of electrophoretic shift assay (EMSA).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	means	means	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
29	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
30	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1262
# text = We provide evidence that FCM strongly inhibits the LPS-induced NF-kappaB activation in PBM.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	_
6	strongly	strongly	ADV	RB	_	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	PBM	PBM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1263
# text = Furthermore, we show that exogenous PGE2 mimics the NF-kappaB inhibitory effect of FCM.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	PGE2	PGE2	NOUN	NN	Number=Sing	_	_	_	_
8	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1264
# text = On the other hand, FCM produced in the presence of indomethacin does not inhibit NF-kappaB activation by LPS.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	FCM	FCm	PROPN	NNP	Number=Sing	_	_	_	_
7	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1265
# text = Our results lend further support to the hypothesis that inflammatory and immune responses of monocytes/macrophages may be modulated at the molecular level by signals originating from tissue structural cells such as fibroblasts.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	lend	lend	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
5	support	support	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
27	originating	originate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
30	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1266
# text = Document 00300130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300130	00300130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1267
# text = Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
4	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1268
# text = Binding of type I interferon (IFN-alpha/beta) to specific receptors results in the rapid transcriptional activation, independent of protein synthesis, of IFN-alpha-stimulated genes (ISGs) in human fibroblasts and HeLa and Daudi cell lines.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	interferon	interferon	X	FW	Foreign=Yes	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha/beta	alpha/beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ISGs	ISGs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1269
# text = The binding of ISGF3 (IFN-stimulated gene factor 3) to the conserved IFN-stimulated response element (ISRE) results in transcriptional activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	3	3	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	ISRE	ISRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1270
# text = This factor is composed of a DNA-binding protein (ISGF3 gamma), which normally is present in the cytoplasm, and other IFN-alpha-activated proteins which preexist as latent cytoplasmic precursors (ISGF3 alpha).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	normally	normally	ADV	RB	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	preexist	preexist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
36	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
37	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1271
# text = We have found that ISG expression in the monocytic U937 cell line differs from most cell lines previously examined.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ISG	ISG	VERB	VBG	VerbForm=Ger	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	previously	previously	ADV	RB	_	_	_	_	_
19	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1272
# text = U937 cells express both type I and type II IFN receptors, but only IFN-alpha is capable of inducing antiviral protection in these cells.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
23	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1273
# text = Pretreatment with IFN-gamma potentiates the IFN-alpha-induced protection, but IFN-gamma alone does not have any antiviral activity.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
6	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	protection	protection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
19	alone	alone	ADV	RB	_	_	_	_	_
20	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
23	any	any	DET	DT	_	_	_	_	_
24	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1274
# text = ISG15 mRNA accumulation in U937 cells is not detectable before 6 h of IFN-alpha treatment, peaks at 24 h, and requires protein synthesis.
1	ISG15	ISG15	NUM	CD	NumType=Card	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
10	before	before	ADP	IN	_	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	24	24	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1275
# text = Although IFN-gamma alone does not induce ISG expression, IFN-gamma pretreatment markedly increases and hastens ISG expression and transcriptional induction.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	alone	alone	NOUN	NN	Number=Sing	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	ISG	ISG	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
15	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	hastens	hasten	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	ISG	ISG	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1276
# text = Nuclear extracts assayed for the presence of ISRE binding factors by electrophoretic mobility shift assays show that ISGF3 is induced by IFN-alpha within 6
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ISRE	Isre	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
13	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
14	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
15	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
16	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	alpha	alpha	ADV	RB	_	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	6	6	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 1277
# text = h from undetectable basal levels in untreated U937 cells.
1	h	h	INTJ	UH	_	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
4	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1278
# text = Activation of ISGF3 alpha, the latent component of ISGF3, occurs rapidly.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	component	component	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	occurs	occurs	ADV	RB	_	_	_	_	_
13	rapidly	rapidly	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1279
# text = However, the increase in ISGF3 activity ultimately correlates with the accumulation of ISGF3 gamma induced by IFN-alpha or IFN-gamma.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	ultimately	ultimately	ADV	RB	_	_	_	_	_
9	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1280
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1281
# text = Document 00300131 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300131	00300131	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1282
# text = Interferon-alpha activates multiple
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1283
# text = STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	upregulates	upregulate	NOUN	NNS	Number=Plur	_	_	_	_
5	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	myc	myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1284
# text = Interferon-alpha (IFN-alpha) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1285
# text = There is increasing evidence that IFN-alpha has an important role in T-cell biology.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1286
# text = We have analyzed the expression of IL-2Ralpha, c-myc, and pim-1 genes in anti-CD3-activated human T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-activated	-activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1287
# text = The induction of these genes is associated with interleukin-2 (IL-2)-induced T-cell proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1288
# text = Treatment of T lymphocytes with IFN-alpha, IL-2, IL-12, and IL-15 upregulated IL-2Ralpha, c-myc, and pim-1 gene expression.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-12	-12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	15	15	NUM	CD	NumType=Card	_	_	_	_
21	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1289
# text = IFN-alpha also sensitized T cells to IL-2-induced proliferation, further suggesting that IFN-alpha may be involved in the regulation of T-cell mitogenesis.
1	IFN-	IFN-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	sensitized	sensitize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	T	t	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	further	further	ADV	RB	_	_	_	_	_
16	suggesting	suggesting	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1290
# text = When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha, pim-1, and IRF-1 GAS elements after cytokine stimulation, we observed IFN-alpha-induced binding of STAT1, STAT3, and STAT4, but not STAT5 to all of these elements.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	observed	observe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	but	but	CCONJ	CC	_	_	_	_	_
48	not	not	ADV	RB	_	_	_	_	_
49	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	all	all	DET	DT	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1291
# text = Yet, IFN-alpha was able to activate binding of STAT5 to the high-affinity IFP53 GAS site.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
18	IFP53	IFP53	NUM	CD	NumType=Card	_	_	_	_
19	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1292
# text = IFN-alpha enhanced tyrosine phosphorylation of STAT1, STAT3, STAT4, STAT5a, and STAT5b.
1	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	STAT5a	STAT5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1293
# text = IL-12 induced STAT4 and IL-2 and IL-15 induced STAT5 binding to the GAS elements.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	STAT4	Stat4	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	15	15	NUM	CD	NumType=Card	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1294
# text = Taken together, our results suggest that IFN-alpha, IL-2, IL-12, and IL-15 have overlapping activities on human T cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-12	-12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	15	15	NUM	CD	NumType=Card	_	_	_	_
23	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1295
# text = These findings thus emphasize the importance of IFN-alpha as a T-cell regulatory cytokine.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1296
# text = Document 00300132 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300132	00300132	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1297
# text = An alternatively spliced isoform of the Spi-B transcription factor.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	alternatively	alternatively	ADV	RB	_	_	_	_	_
3	spliced	spliced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1298
# text = Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-B	-B	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
12	Spi-1/	spi-1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1299
# text = The Ets proteins share a conserved Ets domain that mediates specific DNA binding.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1300
# text = Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-B	-B	PROPN	NNP	Number=Sing	_	_	_	_
3	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	GGAA	GGAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1301
# text = Up to date, the biological function of Spi-B remains unknown.
1	Up	up	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	date	date	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1302
# text = Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	alternatively	alternatively	ADV	RB	_	_	_	_	_
10	spliced	spliced	ADJ	JJ	Degree=Pos	_	_	_	_
11	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	deltaSpi	deltaSpi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-B	-B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Ets	Et	PROPN	NNPS	Number=Plur	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1303
# text = In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%.
1	In	in	ADP	IN	_	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	deltaspi	deltaspi	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	spi	spi	X	AFX	_	_	_	_	SpaceAfter=No
10	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
11	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	around	around	ADV	RB	_	_	_	_	_
20	10%	10%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1304
# text = DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts.
1	DeltaSpi	DeltaSpi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-B	-b	PROPN	NNP	Number=Sing	_	_	_	_
3	product	product	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	recovered	recover	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1305
# text = We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
7	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	recruiting	recruite	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1306
# text = Document 00300133 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300133	00300133	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1307
# text = ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.
1	ZAP	Zap	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	70	70	NUM	CD	NumType=Card	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	UV	UV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1308
# text = Several mammalian responses to UV irradiation, including the activation of NF-kappa B, are believed to involve tyrosine phosphorylation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
3	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
6	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
21	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1309
# text = UV irradiation and H2O2 treatment of T lymphocytes induce protein tyrosine phosphorylation and Ca2+ signals similar to those observed following biological stimulation.
1	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
2	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
22	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1310
# text = We have examined the role of cell surface molecules in these responses.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1311
# text = Normal T lymphocytes whose surface expression of CD3 was depleted showed impaired UV-induced tyrosine phosphorylation and Ca2+ signals.
1	Normal	normal	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
5	surface	surface	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	showed	show	ADJ	JJ	Degree=Pos	_	_	_	_
12	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	UV	UV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1312
# text = Similarly, Jurkat T cell lines deficient in CD3 or CD45 expression also gave impaired UV responses.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	CD45	CD45	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	gave	give	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
16	UV	uv	NOUN	NN	Number=Sing	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1313
# text = However, all these cell types still gave strong Ca2+ and tyrosine phosphorylation responses to H2O2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	PDT	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	types	type	NOUN	NNS	Number=Plur	_	_	_	_
7	still	still	ADV	RB	_	_	_	_	_
8	gave	give	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
10	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1314
# text = The T cell tyrosine kinase ZAP-70 was found to be highly responsive to UV and H2O2 treatment.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	ZAP	Zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	70	70	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1315
# text = ZAP-70 responsiveness to UV required expression of both CD3 and CD45, whereas only CD3 was required for the response to H2O2.
1	ZAP	Zap	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	70	70	NUM	CD	NumType=Card	_	_	_	_
4	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD45	Cd45	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1316
# text = UV-induced activation of NF-kappa B was blocked by CD3 depletion, indicating the importance of such cell surface molecules in biological responses to UV.
1	UV	haUve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
14	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	UV	UV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1317
# text = In nonlymphoid cells, the epidermal growth factor receptor displayed increased tyrosine phosphorylation within seconds of UV irradiation.
1	In	in	ADP	IN	_	_	_	_	_
2	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	seconds	seconds	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
18	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1318
# text = These results suggest that UV-induced signal transduction is mediated via cell surface receptors that normally respond to biological stimulation, whereas
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	UV	uv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	normally	normally	ADV	RB	_	_	_	_	_
18	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	wherea	SCONJ	IN	_	_	_	_	_

# sent_id = 1319
# text = H2O2 is able to partially bypass this requirement.
1	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	bypass	bypass	VERB	VB	VerbForm=Inf	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1320
# text = Document 00300134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300134	00300134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1321
# text = Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells.
1	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	bufalin-	bufalin-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	_
21	U937	U937	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1322
# text = In a previous study, we demonstrated that bufalin, which is an active principle of Chinese medicine, chan'su, caused apoptosis in human leukemia U937 cells by anomalous activation of mitogen-activated protein kinase (MAPK) via the signaling pathway of Ras, Raf-1, and MAPK kinase-1.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	principle	principle	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
18	medicine	medicine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	chan	chan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	'su	'su	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	_
28	U937	U937	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	anomalous	anomalous	ADJ	JJ	Degree=Pos	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	via	via	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
45	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
55	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1323
# text = Here, we report the effect of overexpression of bcl-2 in U937 cells on the signaling pathway of apoptosis that is induced by bufalin.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1324
# text = The results indicated that the apoptosis induced by bufalin in U937 cells was significantly inhibited by overexpression of the Bcl-2 protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1325
# text = No significant difference was detected in the activation of MAPK kinase-1 that is induced by bufalin in wild-type or Bcl-2-overexpressed
1	No	no	DET	DT	_	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 1326
# text = U937 cells; however, the activation of MAPK by bufalin was significantly attenuated in the cells overexpressing Bcl-2.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	;	;	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	bufalin	bufalin	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1327
# text = Bufalin treatment activated activator protein-1 transcriptional activity; however, this activation was decreased to 40% in bcl-2-overexpressed U937 cells.
1	Bufalin	Bufalin	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U937	U937	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1328
# text = These results indicate that Bcl-2 acts downstream of MAPK kinase-1 but upstream of MAPK and suggest that, in the signaling pathway of the apoptotic process induced by bufalin, the transcriptional activity of activator protein-1 may be down-regulated through the inhibition of MAPK activity by Bcl-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
9	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
30	process	process	NOUN	NN	Number=Sing	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
45	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	through	through	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1329
# text = Document 00300135 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300135	00300135	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1330
# text = STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules.
1	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	during	during	ADP	IN	_	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
7	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1331
# text = Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
9	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
10	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	upon	upon	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
21	cultivation	cultivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	closely	closely	ADV	RB	_	_	_	_	_
24	mimicking	mimick	VERB	VBG	VerbForm=Ger	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
28	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
31	into	into	ADP	IN	_	_	_	_	_
32	extravascular	extravascular	ADJ	JJ	Degree=Pos	_	_	_	_
33	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1332
# text = The mediator(s) of this maturation process has not been yet defined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
9	process	process	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	yet	yet	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1333
# text = We investigated the involvement of signal transducers and activators of transcription (STAT) factors in this phenomenon and reported the specific, time-dependent, activation of STAT1 protein starting at day 0/1 of cultivation and maximally expressed at day 5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	day	day	NOUN	NN	Number=Sing	_	_	_	_
35	0/1	0/1	NUM	CD	NumType=Card	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cultivation	cultivation	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	maximally	maximally	ADV	RB	_	_	_	_	_
40	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	day	day	NOUN	NN	Number=Sing	_	_	_	_
43	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1334
# text = STAT1 activity was evident on the STAT binding sequences (SBE) present in the promoters of genes which are up-regulated during monocyte to macrophage maturation such as FcgammaRI and ICAM-1, and in the promoter of the transcription factor IFN regulatory factor-1.
1	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	SBE	SBE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	macrophage	macrophage	VERB	VB	VerbForm=Inf	_	_	_	_
28	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
29	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	FcgammaRI	Fcgammari	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	IFN	Ifn	ADP	IN	_	_	_	_	_
46	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1335
# text = Moreover, the effect of cell adhesion to fibronectin or laminin was studied to investigate mechanisms involved in STAT1 activation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	laminin	laminin	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
16	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1336
# text = Compared with monocytes adherent on plastic surfaces, freshly isolated cells allowed to adhere either to fibronectin- or laminin-coated flasks exhibited an increased STAT1 binding activity both in control and in IFN-gamma-treated cells.
1	Compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
7	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	freshly	freshly	ADV	RB	_	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	adhere	adhere	VERB	VB	VerbForm=Inf	_	_	_	_
15	either	either	ADV	RB	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	fibronectin	fibronectin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	laminin	laminin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	coated	coate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	flasks	flask	NOUN	NNS	Number=Plur	_	_	_	_
24	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1337
# text = The molecular events leading to enhanced STAT1 activation and cytokine responsiveness concerned both Y701 and S727 STAT1 phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
7	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
12	concerned	concern	ADJ	JJ	Degree=Pos	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	Y701	Y701	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	S727	S727	NUM	CD	NumType=Card	_	_	_	_
17	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1338
# text = Exogenous addition of transforming growth factor-beta, which exerts an inhibitory effect on some monocytic differentiation markers, inhibited macrophage maturation, integrin expression and STAT1 binding activity.
1	Exogenous	Exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
29	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1339
# text = Taken together these results indicate that STAT1 plays a pivotal role in the differentiation/maturation process of monocytes as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes, such as ICAM-1 and FcgammaRI.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	initially	initially	ADV	RB	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	then	then	ADV	RB	PronType=Dem	_	_	_	_
31	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	FcgammaRI	FcgammaRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1340
# text = Document 00300136 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300136	00300136	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1341
# text = Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	beta-catenin	beta-catenin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1342
# text = In response to activation of the Wnt signaling pathway, beta-catenin accumulates in the nucleus, where it cooperates with LEF/TCF (for lymphoid enhancer factor and T-cell factor) transcription factors to activate gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Wnt	Wnt	PROPN	NNP	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
14	accumulates	accumulate	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	where	where	ADV	WRB	PronType=Rel	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	for	for	ADP	IN	_	_	_	_	_
28	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1343
# text = The mechanisms by which beta-catenin undergoes this shift in location and participates in activation of gene transcription are unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
8	undergoes	undergo	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	location	location	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1344
# text = We demonstrate here that beta-catenin can be imported into the nucleus independently of LEF/TCF binding, and it may also be exported from nuclei.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	imported	import	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
14	independently	independently	ADV	RB	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	exported	export	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1345
# text = We have introduced a small deletion within beta-catenin (Delta19) that disrupts binding to LEF-1, E-cadherin, and APC but not axin.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Delta19	Delta19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cadherin	cadherin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	APC	APC	PROPN	NNP	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	axin	axin	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1346
# text = This Delta19 beta-catenin mutant localizes to the nucleus because it may not be efficiently sequestered in the cytoplasm.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	Delta19	Delta19	PROPN	NNP	Number=Sing	_	_	_	_
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	localizes	localize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
11	because	because	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	efficiently	efficiently	ADV	RB	_	_	_	_	_
17	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1347
# text = The nuclear localization of Delta19 definitively demonstrates that the mechanisms by which beta-catenin localizes in the nucleus are completely independent of LEF/TCF factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Delta19	Delta19	PROPN	NNP	Number=Sing	_	_	_	_
6	definitively	definitively	ADV	RB	_	_	_	_	_
7	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
16	localizes	localize	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	completely	completely	ADV	RB	_	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1348
# text = beta-Catenin and LEF-1 complexes can activate reporter gene expression in a transformed T-lymphocyte cell line (Jurkat) but not in normal T lymphocytes, even though both factors are nuclear.
1	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Catenin	Catenin	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	T	PROPN	NNP	Number=Sing	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	even	even	ADV	RB	_	_	_	_	_
32	though	though	SCONJ	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1349
# text = Thus, localization of both factors to the nucleus is not sufficient for activation of gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1350
# text = Excess beta-catenin can squelch reporter gene activation by LEF-1-beta-catenin complexes but not activation by the transcription factor VP16.
1	Excess	Excess	NOUN	NN	Number=Sing	_	_	_	_
2	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	squelch	squelch	VERB	VB	VerbForm=Inf	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1-beta	1-beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	VP	vp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1351
# text = Taken together, these data suggest that a third component is necessary for gene activation and that this third component may vary with cell type.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
20	component	component	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	vary	vary	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1352
# text = Document 00300137 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300137	00300137	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1353
# text = One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrens' syndrome.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	autoantigen	autoantigen	ADJ	JJ	Degree=Pos	_	_	_	_
16	La/SS	La/ss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
22	library	library	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	Sjogrens	Sjogrens	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
29	'	'	PART	POS	_	_	_	_	_
30	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1354
# text = A cDNA library was prepared from peripheral blood lymphocytes of an autoimmune patient with primary Sjogrens' syndrome.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	library	library	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
13	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	Sjogrens	sjogrens	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1355
# text = The cDNA library was screened with the patients own autoimmune serum being monospecific for the nuclear autoantigen La/SS-B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	library	library	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	screened	screen	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	own	own	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	monospecific	monospecific	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	autoantigen	autoantigen	NOUN	NN	Number=Sing	_	_	_	_
18	La/SS	La/ss	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1356
# text = Thereby an alternative type of La mRNA was identified that differed from the known La mRNA due to an exchange of the exon 1.
1	Thereby	thereby	ADV	RB	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	La	La	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	differed	differ	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	La	La	PROPN	NNP	Number=Sing	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1357
# text = Sequencing of the genomic region between the exons 1 and 2 showed that the alternative 5'-end is a part of the intron.
1	Sequencing	Sequencing	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	end	end	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1358
# text = In addition, the presence of an alternative promoter site, which exists within the intron downstream of the exon 1, became evident.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
17	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1359
# text = In consequence, the alternative La mRNA is the result of a promoter switching combined with an alternative splicing mechanism.
1	In	in	ADP	IN	_	_	_	_	_
2	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
6	La	La	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	result	result	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	_
15	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
19	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
20	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1360
# text = In the intron, further transcription factor binding sites, including a NF-kappa B element, were identified leading to the suggestion that the expression of the gene encoding for the nuclear autoantigen La/SS-B alters in dependence on disease conditions.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	suggestion	suggestion	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	autoantigen	autoantigen	NOUN	NN	Number=Sing	_	_	_	_
36	La/SS	La/ss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
44	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1361
# text = Document 00300138 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300138	00300138	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1362
# text = Regulation of the tissue factor gene in human monocytic cells.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1363
# text = Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1364
# text = Tissue factor (TF) expression by peripheral blood monocytes during sepsis initiates intravascular thrombosis.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	sepsis	sepsis	ADJ	JJ	Degree=Pos	_	_	_	_
13	initiates	initiate	NOUN	NNS	Number=Plur	_	_	_	_
14	intravascular	intravascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	thrombosis	thrombosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1365
# text = Bacterial lipopolysaccharide (LPS) rapidly induces TF gene transcription in monocytes.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	rapidly	rapidly	ADV	RB	_	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	TF	Tf	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1366
# text = The human TF promoter contains binding sites for the transcription factors AP-1, c-Rel/p65, Egr-1, and Sp1. NF-kappa B/Rel proteins have been shown to physically interact with both AP-1 and Sp1 proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	Rel/p65	Rel/p65	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	physically	physically	ADV	RB	_	_	_	_	_
37	interact	interact	ADV	RB	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	both	both	DET	DT	_	_	_	_	_
40	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
45	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1367
# text = In this study, we investigated the role of these transcription factors in uninduced and LPS-induced TF gene expression in human monocytic THP-1 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1368
# text = Deletional analysis indicated that five Sp1 sites mediated basal expression in uninduced cells.
1	Deletional	Deletional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	five	five	NUM	CD	NumType=Card	_	_	_	_
6	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1369
# text = The two AP-1 sites bound c-Fos/c-Jun heterodimers in both unstimulated and LPS-stimulated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	bound	bound	ADP	IN	_	_	_	_	_
8	c-Fos/c	c-Fos/c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-Jun	-Jun	ADJ	JJ	Degree=Pos	_	_	_	_
10	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1370
# text = Maximal LPS induction of the TF promoter required the two AP-1 sites and the kappa B site within the LPS response element.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1371
# text = Disruption of the conserved spacing between the proximal AP-1 site and the kappa B site abolished LPS induction.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1372
# text = Replacement of the two AP-1 sites with intrinsically bent DNA partially restored LPS induction, suggesting an additional structural role for the AP-1 sites.
1	Replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	intrinsically	intrinsically	ADV	RB	_	_	_	_	_
11	bent	bent	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	partially	partially	ADV	RB	_	_	_	_	_
14	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
21	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1373
# text = Synergistic transactivation of the LPS response element in Drosophila Schneider cells by coexpression of c-Fos, c-Jun, c-Rel, and p65 or c-Jun and p65 required the transactivation domains of c-Jun and p65.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
10	Schneider	Schneider	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	p65	p65	NUM	CD	NumType=Card	_	_	_	_
33	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
36	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1374
# text = These data indicated that c-Fos/c-Jun, c-Rel/p65, and Sp1 regulate TF gene expression in human monocytic cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	c-Rel/p65	c-Rel/p65	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
12	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1375
# text = Document 00300139 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300139	00300139	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1376
# text = Nuclear factor-IL6 activates the human IL-4 promoter in T cells.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1377
# text = Positive regulatory element I (PRE-I) is a strong enhancer element essential for expression of the human IL-4 gene.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1378
# text = To identify transcription factors binding to PRE-I, we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta).
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	screened	screen	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cDNA	cDNA	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	library	library	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
25	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	also	also	ADV	RB	_	_	_	_	_
35	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
40	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1379
# text = NF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone D10, but not in Th1 clone 29.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
16	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
17	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
18	D10	D10	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
24	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
25	29	29	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1380
# text = rNF-IL6 expressed in bacteria was shown to specifically bind to PRE-I.
1	rNF	rNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1381
# text = PRE-I forms multiple DNA-protein complexes with nuclear extracts from Jurkat cells.
1	PRE	pre	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1382
# text = Some of these complexes were demonstrated to contain NF-IL6 by using anti-C/EBP beta Abs.
1	Some	some	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	anti-C	anti-C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
17	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
18	Abs	Abs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1383
# text = Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I-thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
6	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
12	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	than	than	ADP	IN	_	_	_	_	_
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1384
# text = Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 (C/EBP proximal) and -87 to -79 (C/EBP medial), respectively.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
15	-44	-44	NUM	CD	NumType=Card	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	-36	-36	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	_
21	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	87	87	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-79	-79	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	C/	C/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
31	medial	medial	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1385
# text = Our results demonstrate that NF-IL6 is involved in transcriptional activation of the human IL-4 promoter in T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1386
# text = Document 00300140 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300140	00300140	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1387
# text = An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	apparently	apparently	ADV	RB	_	_	_	_	_
11	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
18	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
19	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1388
# text = We have identified a DNA segment that confers responsiveness to antigen stimulation signals on the human interleukin (IL) 4 gene in Jurkat cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	confers	confer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	antigen	antigen	VERB	VB	VerbForm=Inf	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1389
# text = The human IL-4 gene, of 10 kilobases, is composed of four exons and three introns.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	four	four	NUM	CD	NumType=Card	_	_	_	_
16	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	three	three	NUM	CD	NumType=Card	_	_	_	_
19	introns	intron	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1390
# text = A cis-acting element (P sequence) resides in the 5' upstream region; no additional DNA segments with enhancer activity were identified in the human IL-4 gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	P	p	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	resides	reside	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1391
# text = For further mapping purposes, a fusion promoter was constructed with the granulocyte/macrophage colony-stimulating factor basic promoter containing 60 base pairs of sequence upstream from the cap site of the mouse granulocyte/macrophage colony-stimulating factor gene and various lengths of the 5' upstream sequence of the IL-4 gene.
1	For	for	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
4	purposes	purpose	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
16	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	base	base	NOUN	NN	Number=Sing	_	_	_	_
25	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
36	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
39	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
46	lengths	length	NOUN	NNS	Number=Plur	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	'	's	PUNCT	``	_	_	_	_	_
51	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
52	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	4	4	NUM	CD	NumType=Card	_	_	_	_
58	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1392
# text = The P sequence was located between positions -79 and -69 relative to the transcription start site of the human IL-4 gene, and this location was confirmed by base-substitution mutations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	79	79	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	69	69	NUM	CD	NumType=Card	_	_	_	_
13	relative	relative	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	location	location	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
36	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1393
# text = The plasmids carrying multiple copies of the P sequence showed higher responsiveness to the stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
3	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	P	P	PROPN	NNP	Number=Sing	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
12	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1394
# text = The binding protein(s) that recognize the P sequence of the IL-4 gene were identified by DNA-mobility-shift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	s	s	X	AFX	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	P	P	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1395
# text = The binding of NF(P) (a DNA binding protein that specifically recognizes the P sequence) to the P sequence was abolished when oligonucleotides carrying base substitutions were used, indicating that the NF(P) interaction is sequence-specific and that binding specificity of the protein paralleled the sequence requirements for IL-4 expression in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	specifically	specifically	ADV	RB	_	_	_	_	_
15	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	P	p	NOUN	NN	Number=Sing	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	when	when	ADV	WRB	PronType=Int	_	_	_	_
27	oligonucleotides	oligonucleotides	SCONJ	IN	_	_	_	_	_
28	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
29	base	base	NOUN	NN	Number=Sing	_	_	_	_
30	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	that	that	SCONJ	IN	_	_	_	_	_
48	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
49	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
53	paralleled	parallel	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
56	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
60	4	4	NUM	CD	NumType=Card	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1396
# text = The P sequence does not share homology with the 5' upstream sequence of the IL-2 gene, even though surrounding sequences of the IL-4 gene share high homology with the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	share	share	VERB	VB	VerbForm=Inf	_	_	_	_
7	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	``	_	_	_	_	_
12	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	even	even	ADV	RB	_	_	_	_	_
22	though	though	SCONJ	IN	_	_	_	_	_
23	surrounding	surround	VERB	VBG	VerbForm=Ger	_	_	_	_
24	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	share	share	NOUN	NN	Number=Sing	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1397
# text = We conclude that a different set of proteins recognize IL-2 and IL-4 genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	set	set	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1398
# text = Document 00300141 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300141	00300141	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1399
# text = PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells.
1	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1400
# text = BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
4	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
18	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1401
# text = Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation.
1	Better	better	ADJ	JJ	Degree=Pos	_	_	_	_
2	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	ECs	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
17	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1402
# text = Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives.
1	Peroxisome	Peroxisome	DET	DT	_	_	_	_	_
2	proliferator	proliferator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	member	member	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
27	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
28	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	fibric	fibric	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
32	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1403
# text = The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1404
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1405
# text = Immunohistochemistry revealed that human carotid artery ECs express PPARalpha.
1	Immunohistochemistry	Immunohistochemistry	PROPN	NNP	Number=Sing	_	_	_	_
2	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	carotid	carotid	NOUN	NN	Number=Sing	_	_	_	_
6	artery	artery	NOUN	NN	Number=Sing	_	_	_	_
7	ECs	Ecs	PROPN	NNP	Number=Sing	_	_	_	_
8	express	express	PROPN	NNP	Number=Sing	_	_	_	_
9	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1406
# text = Pretreatment of cultured human ECs with the PPARalpha activators fenofibrate or WY14643 inhibited TNF-alpha-induced VCAM-1 in a time- and concentration-dependent manner, an effect not seen with PPARgamma activators.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	fenofibrate	fenofibrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	WY	WY	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	14643	14643	NUM	CD	NumType=Card	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
39	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1407
# text = Both PPARalpha activators decreased cytokine-induced VCAM-1 mRNA expression without altering its mRNA half-life.
1	Both	both	DET	DT	_	_	_	_	_
2	PPARalpha	PPARalpha	NOUN	NN	Number=Sing	_	_	_	_
3	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
4	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	without	without	SCONJ	IN	_	_	_	_	_
14	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
16	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	life	life	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1408
# text = Transient transfection of deletional VCAM-1 promoter constructs and electrophoretic mobility shift assays suggest that fenofibrate inhibits VCAM-1 transcription in part by inhibiting NF-kappaB.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	deletional	deletional	ADJ	JJ	Degree=Pos	_	_	_	_
5	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
15	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	fenofibrate	fenofibrate	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
19	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	part	part	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1409
# text = Finally, PPARalpha activators significantly reduced adhesion of U937 cells to cultured human ECs.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	U937	U937	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	ECs	EC	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1410
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1411
# text = Human ECs express PPARalpha, a potentially important regulator of atherogenesis through its transcriptional control of VCAM-1 gene expression.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potentially	potentially	ADV	RB	_	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1412
# text = Such findings also have implications regarding the clinical use of lipid-lowering agents, like fibric acids, which can activate PPARalpha.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
6	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	use	use	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	lowering	lowering	VERB	VBG	VerbForm=Ger	_	_	_	_
14	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	like	like	ADP	IN	_	_	_	_	_
17	fibric	fibric	ADJ	JJ	Degree=Pos	_	_	_	_
18	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
23	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1413
# text = Document 00300142 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300142	00300142	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1414
# text = Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells [see comments] BOB.1/OBF.1 is a transcriptional coactivator that is constitutively expressed in B cells and interacts with the Oct1 and Oct2 transcription factors.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
7	BOB.1/OBF	BOB.1/OBF	ADP	IN	_	_	_	_	SpaceAfter=No
8	.1	.1	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
16	BOB.1/OBF	BOB.1/OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.1	.1	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Oct1	oct1	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1415
# text = Upon activation of Jurkat T cells and primary murine thymocytes with phorbol esters and ionomycin, BOB.1/OBF.1 expression and transactivation function were induced.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	BOB.1/OBF	BOB.1/OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.1	.1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1416
# text = BOB.1/OBF.1 was phosphorylated at Ser184 both in vivo and in vitro, and this modification was required for inducible activation.
1	BOB.1/OBF	BOB.1/OBF	ADP	IN	_	_	_	_	SpaceAfter=No
2	.1	.1	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	Ser184	Ser184	PROPN	NNP	Number=Sing	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1417
# text = Mutation of Ser184 also diminished transactivation function in B cells, suggesting that the activating phosphorylation that is inducible in T cells is constitutively present in B cells.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Ser184	Ser184	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1418
# text = Thus, BOB.1/OBF.1 is a transcriptional coactivator that is critically regulated by posttranslational modifications to mediate cell type-specific gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	BOB.1/OBF	BOB.1/OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	.1	.1	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	critically	critically	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
15	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1419
# text = Document 00300143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300143	00300143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1420
# text = Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
1	Oncogenic	Oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
2	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
5	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	retain	retain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1421
# text = Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.
1	Truncated	Truncated	ADJ	JJ	Degree=Pos	_	_	_	_
2	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
6	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	engineered	engineer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	resemble	resemble	VERB	VB	VerbForm=Inf	_	_	_	_
11	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
12	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
18	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	leukemia/	leukemiaith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	ALL	All	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	efficiently	efficiently	ADV	RB	_	_	_	_	_
31	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	ALL	all	ADV	RB	_	_	_	_	_
35	when	when	ADV	WRB	PronType=Int	_	_	_	_
36	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
40	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1422
# text = Unlike full-sized NOTCH1, two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN) were found to activate transcription in cultured cells, presumably through RBP-Jkappa response elements within DNA.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	sized	size	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NOTCH1	Notch1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
9	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
18	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	DeltaE	DeltaE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	consisting	consist	VERB	VBG	VerbForm=Ger	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ICN	ICN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	presumably	presumably	ADV	RB	_	_	_	_	_
46	through	through	ADP	IN	_	_	_	_	_
47	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
50	response	response	NOUN	NN	Number=Sing	_	_	_	_
51	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
52	within	within	ADP	IN	_	_	_	_	_
53	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1423
# text = Both truncated forms also bound to the transcription factor RBP-Jkappa in extracts prepared from human and murine T-ALL cell lines.
1	Both	both	DET	DT	_	_	_	_	_
2	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
15	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	human	human	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	ALL	all	DET	DT	_	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1424
# text = Transcriptional activation required the presence of a weak RBP-Jkappa-binding site within the NOTCH1 ankyrin repeat region of the intracellular domain.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
9	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NOTCH1	Notch1	NOUN	NN	Number=Sing	_	_	_	_
18	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
19	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1425
# text = Unexpectedly, a second, stronger RBP-Jkappa-binding site, which lies within the intracellular domain close to the transmembrane region and significantly augments association with RBP-Jkappa, was not needed for oncogenesis or for transcriptional activation.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
7	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	significantly	significantly	ADV	RB	_	_	_	_	_
27	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
28	association	association	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	oncogenesis	oncogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1426
# text = While ICN appeared primarily in the nucleus, DeltaE localized to cytoplasmic and nuclear membranes, suggesting that intranuclear localization is not essential for oncogenesis or transcriptional activation.
1	While	while	SCONJ	IN	_	_	_	_	_
2	ICN	ICN	PROPN	NNP	Number=Sing	_	_	_	_
3	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	primarily	primarily	ADV	RB	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	DeltaE	DeltaE	PROPN	NNP	Number=Sing	_	_	_	_
10	localized	localize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	intranuclear	intranuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	oncogenesis	oncogenesis	ADJ	JJ	Degree=Pos	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1427
# text = In support of this interpretation, mutation of putative nuclear localization sequences decreased nuclear localization and increased transcriptional activation by membrane-bound DeltaE.
1	In	in	ADP	IN	_	_	_	_	_
2	support	support	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interpretation	interpretation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
24	DeltaE	Delta	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1428
# text = Transcriptional activation by this mutant form of membrane-bound DeltaE was approximately equivalent to that produced by intranuclear ICN.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
11	DeltaE	DeltaE	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	approximately	approximately	ADV	RB	_	_	_	_	_
14	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	intranuclear	intranuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	ICN	Icn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1429
# text = These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
8	oncogenesis	oncogenesis	PROPN	NNPS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1430
# text = Document 00300144 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300144	00300144	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1431
# text = Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging.
1	Impaired	Impaired	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	fos/c-jun	fos/c-jun	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	c-fos/c-jun	c-fos/c-jun	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1432
# text = The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	often	often	ADV	RB	_	_	_	_	_
21	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1433
# text = In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	whether	whether	SCONJ	IN	_	_	_	_	_
9	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	fos/c-jun	fos/c-jun	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
23	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	age-	age-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1434
# text = Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
6	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
13	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
14	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	_
15	plus	plus	CCONJ	CC	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lectin	lectin	PROPN	NNP	Number=Sing	_	_	_	_
21	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
22	plus	plus	CCONJ	CC	_	_	_	_	_
23	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
24	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
26	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	not	not	ADV	RB	_	_	_	_	_
42	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
43	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	markedly	markedly	ADV	RB	_	_	_	_	_
46	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	from	from	ADP	IN	_	_	_	_	_
52	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
53	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
54	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1435
# text = In addition,
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 1436
# text = RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects.
1	RNase	RNase	NOUN	NN	Number=Sing	_	_	_	_
2	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	anti-CD3/PMA	anti-CD3/PMa	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
14	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
17	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
18	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	or	or	CCONJ	CC	_	_	_	_	_
28	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
37	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1437
# text = Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	jun	jun	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	TRE	Tre	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
37	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	element	element	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1438
# text = Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
9	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
10	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
27	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
32	SRE	Sre	ADJ	JJ	Degree=Pos	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
35	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
40	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
55	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
56	TRE	tre	NOUN	NN	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
59	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
60	SRE	Sre	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
61	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
62	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1439
# text = Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
20	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
21	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Elk	elk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	pointing	point	VERB	VBG	VerbForm=Ger	_	_	_	_
30	toward	toward	ADP	IN	_	_	_	_	_
31	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
34	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
42	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
43	from	from	ADP	IN	_	_	_	_	_
44	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
45	jun/AP	jun/AP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1440
# text = These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
6	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	fos/c-jun	fos/c-jun	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
27	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1441
# text = Document 00300145 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300145	00300145	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1442
# text = SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity.
1	SLP	Slp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-76	-76	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1443
# text = SLP-76 and Vav, two hematopoietic cell specific molecules, are critical for T cell development and activation.
1	SLP	Slp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-76	-76	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	development	development	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1444
# text = Following
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 1445
# text = T cell antigen receptor stimulation, SLP-76 and Vav both undergo tyrosine phosphorylation and associate with each other via the SH2 domain of Vav and phosphorylated tyrosines of SLP-76.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	76	76	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	associate	associate	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	each	each	DET	DT	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1446
# text = Furthermore, SLP-76 and Vav have a synergistic effect on interleukin (IL)-2 promoter activity in T cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	76	76	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
8	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1447
# text = In this report, we show that two tyrosines, Tyr-113 and Tyr-128, of SLP-76 are required for its binding to Vav, both in vitro and in intact cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Tyr	Tyr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	113	113	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Tyr	Tyr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-128	-128	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	SLP	sLp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	76	76	NUM	CD	NumType=Card	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1448
# text = Surprisingly, we find also that the interaction between SLP-76 and Vav is not required for their cooperation in augmenting IL-2 promoter activity, as the two molecules appear to function in different signaling pathways upstream of IL-2 gene expression.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	76	76	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
33	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
38	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
39	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
40	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1449
# text = Overexpression of SLP-76 in the Jurkat T cell line potentiates the activities of both nuclear factor of activated T cells and AP-1 transcription factors.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	76	76	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1450
# text = In contrast, overexpression of Vav leads to enhanced nuclear factor of activated T cells activity without affecting AP-1.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	SCONJ	IN	_	_	_	_	_
18	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1451
# text = Additionally, overexpression of Vav, but not SLP-76, augments CD28-induced IL-2 promoter activity.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	SLP	sLp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
14	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1452
# text = These findings suggest that the synergy between SLP-76 and Vav in regulating IL-2 gene expression reflects the cooperation between different signaling pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	76	76	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1453
# text = Document 00300146 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300146	00300146	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1454
# text = Human immunodeficiency virus type-2 gene expression: two enhancers and their activation by T-cell activators.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1455
# text = The human immunodeficiency viruses (HIVs) may include a spectrum of retroviruses with varying potential to infect their host, undergo long periods of latent infection, and induce pathology.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	varying	vary	NOUN	NN	Number=Sing	_	_	_	_
16	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	undergo	undergo	ADV	RB	_	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	periods	periods	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1456
# text = Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats (LTRs), this study was directed to an analysis of the regulatory elements in the HIV-2 LTR.
1	Since	since	ADP	IN	_	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
9	part	part	NOUN	NN	Number=Sing	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	study	study	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1457
# text = The HIV-2 LTR was found to contain two enhancers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1458
# text = One of these enhancers is, in part, identical to the HIV-1 enhancer.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1459
# text = This enhancer in HIV-1 is the T-cell activation response element; in HIV-2, however, it is the second enhancer that is mainly responsible for activation in response to T-cell activators.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	mainly	mainly	ADV	RB	_	_	_	_	_
30	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1460
# text = The second enhancer interacts with two nuclear binding proteins (85 kD and 27 kD mobility) that appear to be required for optimal enhancer function and activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	85	85	NUM	CD	NumType=Card	_	_	_	_
12	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	27	27	NUM	CD	NumType=Card	_	_	_	_
15	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
16	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1461
# text = Observations such as these encourage the speculation that there may be subtle differences in the regulation of HIV-1 and HIV-2 expression that may be relevant to the possible longer latency and reduced pathogenicity of HIV-2.
1	Observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	encourage	encourage	NOUN	NN	Number=Sing	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	speculation	speculation	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	there	there	PRON	EX	_	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	VERB	VB	VerbForm=Inf	_	_	_	_
12	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
33	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
34	latency	latency	ADV	RB	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	pathogenicity	pathogenicity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1462
# text = Document 00300147 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300147	00300147	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1463
# text = Vitamin
1	Vitamin	Vitamin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1464
# text = E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.
1	E	e	NOUN	NN	Number=Sing	_	_	_	_
2	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
5	CCl4	CCl4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
9	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1465
# text = Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
7	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
8	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	which	which	DET	WDT	PronType=Int	_	_	_	_
17	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
18	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
23	etiologies	etiology	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1466
# text = Oxidative stress enhances nuclear factor kappa B (NF-kappa B) activity, and NF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
3	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1467
# text = Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl4 in mice.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
4	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
8	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	intraperitoneal	intraperitoneal	ADJ	JJ	Degree=Pos	_	_	_	_
15	injection	injection	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CCl4	Ccl4	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1468
# text = This injury was significantly inhibited by intravenous pretreatment of the mice with a water-soluble emulsion of alpha-tocopherol.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	intravenous	intravenous	ADJ	JJ	Degree=Pos	_	_	_	_
8	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	water	water	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
17	emulsion	emulsion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1469
# text = Alpha-tocopherol treatment of the mice given the CCl4 also reduced the NF-kappa B binding to levels approaching those found in normal mice.
1	Alpha	Alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CCl4	CCl4	PROPN	NNP	Number=Sing	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	approaching	approach	VERB	VBG	VerbForm=Ger	_	_	_	_
22	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1470
# text = In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in tumor necrosis factor-alpha (TNF-alpha) messenger RNA levels.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CCl4	CCl4	PROPN	NNP	Number=Sing	_	_	_	_
13	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
36	RNA	RNA	ADP	IN	_	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1471
# text = Liver specimens taken from patients with acute fulminant hepatitis had markedly increased NF-kappa B binding activity in comparison with the binding of normal livers.
1	Liver	liver	PROPN	NNP	Number=Sing	_	_	_	_
2	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
3	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
8	fulminant	fulminant	ADJ	JJ	Degree=Pos	_	_	_	_
9	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	livers	liver	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1472
# text = These data demonstrate that abolishing acute hepatic injury with alpha-tocopherol, a free radical scavenger, also eliminated increased NF-kappa B binding.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	abolishing	abolish	VERB	VBG	VerbForm=Ger	_	_	_	_
6	acute	acute	ADV	RB	_	_	_	_	_
7	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
8	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
17	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1473
# text = It is tempting to speculate that enhanced NF-kappa B expression caused by free radical production/oxidative stress may modulate liver injury, perhaps through an effect on cytotoxic cytokine synthesis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	tempting	tempt	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	speculate	speculate	VERB	VB	VerbForm=Inf	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
20	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
24	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	perhaps	perhaps	ADV	RB	_	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1474
# text = Document 00300148 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300148	00300148	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1475
# text = Limited proteolysis for assaying ligand binding affinities of nuclear receptors.
1	Limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	SCONJ	IN	_	_	_	_	_
4	assaying	assay	VERB	VBG	VerbForm=Ger	_	_	_	_
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1476
# text = The binding of natural or synthetic ligands to nuclear receptors is the triggering event leading to gene transcription activation or repression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
14	event	event	NOUN	NN	Number=Sing	_	_	_	_
15	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1477
# text = Ligand binding to the ligand binding domain of these receptors induces conformational changes that are evidenced by an increased resistance of this domain to proteases.
1	Ligand	Ligand	PROPN	NNP	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
12	conformational	conformational	ADJ	JJ	Degree=Pos	_	_	_	_
13	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1478
# text = In vitro labeled receptors were incubated with various synthetic or natural agonists or antagonists and submitted to trypsin digestion.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
3	labeled	label	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
12	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	submitted	submit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	trypsin	trypsin	VERB	VB	VerbForm=Inf	_	_	_	_
19	digestion	digestion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1479
# text = Proteolysis products were separated by SDS-PAGE and quantified.
1	Proteolysis	Proteolysis	PROPN	NNP	Number=Sing	_	_	_	_
2	products	product	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	SDS	SDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	PAGE	page	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	quantified	quantify	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1480
# text = The amount of trypsin-resistant fragments was proportional to receptor occupancy by the ligand, and allowed the determination of dissociation constants (kDa).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	trypsin-	trypsin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	proportional	proportional	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	receptor	receptor	VERB	VB	VerbForm=Inf	_	_	_	_
11	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
22	constants	constant	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1481
# text = Using the wild-type or mutated human retinoic acid receptor alpha as a model, kDa values determined by classical competition binding assays using tritiated ligands are in agreement with those measured by the proteolytic assay.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
18	values	value	NOUN	NNS	Number=Plur	_	_	_	_
19	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
22	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	tritiated	tritiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
33	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1482
# text = This method was successfully extended to human retinoic X receptor alpha, glucocorticoid receptor, and progesterone receptor, thus providing a basis for a new, faster assay to determine simultaneously the affinity and conformation of receptors when bound to a given ligand.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	method	method	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	successfully	successfully	ADV	RB	_	_	_	_	_
5	extended	extend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	retinoic	retinoic	NOUN	NN	Number=Sing	_	_	_	_
9	X	x	SYM	SYM	_	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	faster	faster	ADJ	JJR	Degree=Cmp	_	_	_	_
29	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
32	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
39	when	when	ADV	WRB	PronType=Int	_	_	_	_
40	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1483
# text = Document 00300149 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300149	00300149	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1484
# text = Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
5	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	YY	YY	INTJ	UH	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1485
# text = 3' enhancer and the immunoglobulin heavy-chain mu E1 site.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	'	'	PUNCT	``	_	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
7	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
11	E1	E1	NUM	CD	NumType=Card	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1486
# text = We have determined that the developmental control of immunoglobulin kappa 3' enhancer (kappa E3') activity is the result of the combined influence of positive- and negative-acting elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'	'	PUNCT	``	_	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	result	result	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1487
# text = We show that a central core in the kappa E3' enhancer is active at the pre-B-cell stage but is repressed by flanking negative-acting elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	core	core	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
18	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1488
# text = The negative-acting sequences repress enhancer activity in a position- and orientation-independent manner at the pre-B-cell stage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	repress	repress	NOUN	NN	Number=Sing	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
21	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1489
# text = We have isolated a human cDNA clone encoding a zinc finger protein (NF-E1) that binds to the negative-acting segment of the kappa E3' enhancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
7	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
11	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
25	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	'	'	PUNCT	''	_	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1490
# text = This protein also binds to the immunoglobulin heavy-chain enhancer mu E1 site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
8	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
13	E1	E1	NUM	CD	NumType=Card	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1491
# text = NF-E1 is encoded by the same gene as the YY-1 protein, which binds to the adeno-associated virus P5 promoter.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	YY	YY	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adeno	adeno	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	P5	p5	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1492
# text = NF-E1 is also the human homologue of the mouse delta protein, which binds to ribosomal protein gene promoters.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	ribosomal	ribosomal	VERB	VB	VerbForm=Inf	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1493
# text = The predicted amino acid sequence of this protein contains features characteristic of transcriptional activators as well as transcriptional repressors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
11	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1494
# text = Cotransfection studies with this cDNA indicate that it can repress basal promoter activity.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
11	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1495
# text = The apparent dual function of this protein is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
3	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1496
# text = Document 00300150 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300150	00300150	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1497
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1498
# text = A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	interferes	interfere	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1499
# text = The transcription factor NF-kappa B controls the induction of numerous cytokine promoters during the activation of T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1500
# text = Inhibition of T cell activation by the immunosuppressants cyclosporin A (CsA) and FK506 exerts a suppressive effect on the induction of these NF-kappa B-controlled cytokine promoters.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
9	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
10	A	A	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
16	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1501
# text = We show for human Jurkat T leukemia cells, as well as human and mouse primary T lymphocytes, that this inhibitory effect is accompanied by an impaired nuclear translocation of the Rel proteins c-Rel, RelA/p65 and NF-kappa B1/p50, whereas the nuclear appearance of RelB remains unaffected.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	mouse	mouse	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	NOUN	NN	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
34	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B1/	b1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	whereas	whereas	SCONJ	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
52	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
55	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1502
# text = CsA does not interfere with the synthesis of Rel proteins, but prevents the inducible degradation of cytosolic NF-kappa B inhibitors I kappa B alpha and I kappa B beta upon T cell activation.
1	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibitors	inhibitor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
33	upon	upon	ADP	IN	_	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1503
# text = CsA neither inhibits the processing of the NF-kappa B1 precursor p105 to p50, nor does it "stabilize" the C-terminal portion of p105, I kappa
1	CsA	csa	ADP	IN	_	_	_	_	_
2	neither	neither	DET	DT	_	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	p105	p105	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
21	stabilize	stabilize	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	"	"	PUNCT	''	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1504
# text = B gamma, which is degraded during p105 processing to mature p50.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	p105	p105	NUM	CD	NumType=Card	_	_	_	_
9	processing	process	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1505
# text = These results indicate that CsA interferes with a specific event in the signal-induced degradation of I kappa B alpha and I kappa B beta, but does not affect the processing of NF-kappa B1/p105 to p50.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
6	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	event	event	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B1/p105	b1/p105	PROPN	NNP	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1506
# text = Document 00300151 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300151	00300151	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1507
# text = Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
1	Structural	Structural	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1508
# text = CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
1	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
7	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
11	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	thrombospondin	thrombospondin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	collagens	collagen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IV	iv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	oxidized	oxidize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
27	density	density	NOUN	NN	Number=Sing	_	_	_	_
28	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	anionic	anionic	ADJ	JJ	Degree=Pos	_	_	_	_
34	phospholipids	phospholipid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	parasitized	parasitize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	Plasmodium	Plasmodium	NOUN	NN	Number=Sing	_	_	_	_
41	falciparum	falciparum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1509
# text = Its expression is restricted to a few cell types, including monocyte/macrophages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
2	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1510
# text = In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	foam	foam	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	oxidized	oxidized	ADJ	JJ	Degree=Pos	_	_	_	_
22	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
23	density	density	NOUN	NN	Number=Sing	_	_	_	_
24	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1511
# text = To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	36	36	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1512
# text = Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	36	36	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
18	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	158	158	NUM	CD	NumType=Card	_	_	_	_
24	base	base	NOUN	NN	Number=Sing	_	_	_	_
25	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
26	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	direct	direct	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1513
# text = Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
1	Within	within	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	above	above	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
8	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
9	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	158	158	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	90	90	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1514
# text = Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
1	Biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	158/-90	158/-90	NUM	CD	NumType=Card	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	core-binding	core-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PEBP2/	PEBP2ith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	position	position	NOUN	NN	Number=Sing	_	_	_	_
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	103	103	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1515
# text = Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	markedly	markedly	ADV	RB	_	_	_	_	_
8	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	CBF	Cbf	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	36	36	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1516
# text = The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	members	member	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
16	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	highlights	highlight	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
53	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
54	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
58	by	by	ADP	IN	_	_	_	_	_
59	members	member	NOUN	NNS	Number=Plur	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
64	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1517
# text = Document 00300152 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300152	00300152	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1518
# text = Transcription factor activation and functional stimulation of human monocytes.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1519
# text = Activation of expression of genes encoding transcription factors:
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1520
# text = c-fos and c-jun and formation of AP1 transcriptional complex in human monocytes was investigated.
1	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	investigated	investigated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1521
# text = It was found that lipopolysaccharide induced strongly both c-fos and c-jun expression as well as AP1 formation.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	ADV	RB	_	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	strongly	strongly	ADV	RB	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
19	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1522
# text = Interferon gamma activated strongly c-fos and weakly c-jun and AP1.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
2	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
3	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	weakly	weakly	ADV	RB	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1523
# text = Tumor necrosis factor induced slightly c-fos and had almost no effect on c-jun and AP1.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	slightly	slightly	ADV	RB	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	almost	almost	ADV	RB	_	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1524
# text = The data suggest that differences in functional responses elicited in monocytes by all three factors may be dependent on different routes on nuclear signalling employed by the factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
9	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	all	all	DET	DT	_	_	_	_	_
14	three	three	NUM	CD	NumType=Card	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	routes	route	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
25	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1525
# text = Document 00300153 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300153	00300153	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1526
# text = Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development.
1	Potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
4	attenuation	attenuation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	live	live	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	gain	gain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IkappaB-	IkappaB-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	alphaS32/	alphas32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	36A	36A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	vaccine	vaccine	NOUN	NN	Number=Sing	_	_	_	_
33	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1527
# text = Live-attenuated human immunodeficiency viruses (HIVs) are candidates for Acquired Immunodeficiency Syndrome (AIDS) vaccine.
1	Live	Live	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	Acquired	acquired	PROPN	NNP	Number=Sing	_	_	_	_
14	Immunodeficiency	Immunodeficiency	PROPN	NNP	Number=Sing	_	_	_	_
15	Syndrome	Syndrome	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	vaccine	vaccine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1528
# text = Based on the simian immunodeficiency virus (SIV) model for AIDS, loss-of-function (e.g. deletion of accessory genes such as nef) has been forwarded as a primary approach for creating enfeebled, but replication-competent, HIV-1/SIV.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	SIV	SIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	model	model	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	e.g.	e.g.	X	FW	_	_	_	_	_
21	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	nef	nef	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	forwarded	forward	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
35	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
36	for	for	SCONJ	IN	_	_	_	_	_
37	creating	create	VERB	VBG	VerbForm=Ger	_	_	_	_
38	enfeebled	enfeebled	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	competent	competent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
48	SIV	Siv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1529
# text = Regrettably, recent evidence suggests that loss-of-function alone is not always sufficient to prevent the emergence of virulent mutants.
1	Regrettably	Regrettably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	loss	lose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	alone	alone	ADV	RB	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	always	always	ADV	RB	_	_	_	_	_
16	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	virulent	virulent	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1530
# text = New strategies that attenuate via mechanisms distinct from loss-of-function are needed for enhancing the safety phenotype of viral genome.
1	New	new	ADJ	JJ	Degree=Pos	_	_	_	_
2	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	attenuate	attenuate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	via	via	ADP	IN	_	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	SCONJ	IN	_	_	_	_	_
17	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	safety	safety	NOUN	NN	Number=Sing	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1531
# text = Here, we propose gain-of-function to be used simultaneously with loss-of-function as a novel approach for attenuating HIV-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	gain	gain	ADV	RB	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	function	function	NOUN	NN	Number=Sing	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
23	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	attenuating	attenuating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1532
# text = We have constructed an HIV-1 genome carrying the cDNA of a proteolysis-resistant nuclear factor-kappaB inhibitor (IkappaB-alphaS32/36A) in the nef region.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
9	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	IkappaB-alphaS32/	Ikappab-alphas32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	36A	36a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1533
# text = HIV-1 expressing IkappaB-alphaS32/36A down-regulates viral expression and is highly attenuated in both Jurkat and peripheral blood mononuclear cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	expressing	expressing	NOUN	NN	Number=Sing	_	_	_	_
5	IkappaB-	IkappaB-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
6	alphaS32/36A	alphaS32/36a	X	GW	_	_	_	_	_
7	down	down	X	GW	_	_	_	_	SpaceAfter=No
8	-regulates	-regulate	X	GW	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1534
# text = We provide formal proof that the phenotypic and attenuating characteristics of IkappaB-alphaS32/36A permit its stable maintenance in a live, replicating HIV-1 despite 180 days of forced ex vivo passaging in tissue culture.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	formal	formal	ADJ	JJ	Degree=Pos	_	_	_	_
4	proof	proof	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phenotypic	phenotypic	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	attenuating	attenuating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IkappaB-	Ikappab-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	alphaS32/	alphas32/	SYM	SYM	_	_	_	_	SpaceAfter=No
14	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	permit	permit	NOUN	NN	Number=Sing	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
18	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
20	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	live	live	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	replicating	replicating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	despite	despite	ADP	IN	_	_	_	_	_
30	180	180	NUM	CD	NumType=Card	_	_	_	_
31	days	day	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	forced	force	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	ex	ex	NOUN	NN	Number=Sing	_	_	_	_
35	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
36	passaging	passaging	VERB	VBG	VerbForm=Ger	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
39	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1535
# text = As compared with other open-reading frames embedded into HIV/SIV genome, this degree of stability is unprecedented.
1	As	as	SCONJ	IN	_	_	_	_	_
2	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	open	open	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
8	frames	frame	NOUN	NNS	Number=Plur	_	_	_	_
9	embedded	embed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	SIV	SIV	PROPN	NNP	Number=Sing	_	_	_	_
14	genome	genome	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unprecedented	unprecedented	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1536
# text = Thus, IkappaB-alphaS32/36A offers proof-of-principle that artifactually gained functions, when used to attenuate the replication of live HIV-1, can be stable.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IkappaB-	IkappaB-	X	GW	_	_	_	_	SpaceAfter=No
4	alphaS32/36A	alphaS32/36a	X	FW	Foreign=Yes	_	_	_	_
5	offers	offer	X	GW	_	_	_	_	_
6	proof	proof	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	principle	principle	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	artifactually	artifactually	ADV	RB	_	_	_	_	_
13	gained	gain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	attenuate	attenuate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	live	live	ADJ	JJ	Degree=Pos	_	_	_	_
24	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1537
# text = These findings illustrate gain-of-function as a feasible strategy for developing safer live-attenuated HIVs to be tested as candidates for AIDS vaccine.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	illustrate	illustrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	gain	gain	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	feasible	feasible	ADJ	JJ	Degree=Pos	_	_	_	_
12	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	SCONJ	IN	_	_	_	_	_
14	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
15	safer	safer	ADJ	JJR	Degree=Cmp	_	_	_	_
16	live	live	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
27	vaccine	vaccine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1538
# text = Document 00300154 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300154	00300154	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1539
# text = Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.
1	Control	Control	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	X	GW	_	_	_	_	_
5	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
6	alpha	alpha	X	GW	_	_	_	_	_
7	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1540
# text = I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	GW	_	_	_	_	_
3	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	GW	_	_	_	_	_
5	inhibits	inhibits	X	ADD	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	retaining	retain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1541
# text = Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	typically	typically	ADV	RB	_	_	_	_	_
5	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	rapidly	rapidly	ADV	RB	_	_	_	_	_
13	inactivate	inactivate	ADJ	JJ	Degree=Pos	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	GW	_	_	_	_	_
16	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1542
# text = This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	liberates	liberate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	initiate	initiate	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	organism	organism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1543
# text = Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1544
# text = When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	either	either	CCONJ	CC	_	_	_	_	_
3	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	32	32	NUM	CD	NumType=Card	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	36	36	NUM	CD	NumType=Card	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	undergo	undergo	ADV	RB	_	_	_	_	_
23	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1545
# text = These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1546
# text = Document 00300155 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300155	00300155	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1547
# text = TAR-independent transactivation by
1	TAR	Tar	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_

# sent_id = 1548
# text = Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CNS	Cn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1549
# text = The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive infection and is a potential target for antiviral therapy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
27	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1550
# text = Tat, a potent activator of HIV-1 gene expression, serves to greatly increase the rate of transcription directed by the viral promoter.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	greatly	greatly	ADV	RB	_	_	_	_	_
16	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1551
# text = This induction, which seems to be an important component in the progression of acquired immune deficiency syndrome (AIDS), may be due to increased transcriptional initiation, increased transcriptional elongation, or a combination of these processes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	acquired	acquire	ADJ	JJ	Degree=Pos	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
40	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1552
# text = Much attention has been focused on the interaction of Tat with a specific RNA target termed TAR (transactivation responsive) which is present in the leader sequence of all HIV-1 mRNAs.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	attention	attention	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
15	target	target	AUX	VB	VerbForm=Inf	_	_	_	_
16	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	all	all	DET	DT	_	_	_	_	_
31	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1553
# text = This interaction is believed to be an important component of the mechanism of transactivation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1554
# text = In this report we demonstrate that in certain CNS-derived cells
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
9	CNS	CNS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 1555
# text = Tat is capable of activating HIV-1 through a TAR-independent pathway.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
4	of	of	SCONJ	IN	_	_	_	_	_
5	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1556
# text = A Tat-responsive element is found upstream within the viral promoter that in glial-derived cell lines allows transactivation in the absence of TAR.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	TAR	TAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1557
# text = Deletion mapping and hybrid promoter constructs demonstrate that the newly identified Tat-responsive element corresponds to a sequence within the viral long terminal repeat (LTR) previously identified as the HIV-1 enhancer, or NF-kappa B domain.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	newly	newly	ADV	RB	_	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
25	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	previously	previously	ADV	RB	_	_	_	_	_
30	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1558
# text = DNA band-shift analysis reveals NF-kappa B binding activity in glial cells that differs from that present in T lymphoid cells.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	band	band	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	differs	differ	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	present	present	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1559
# text = Further, we observe that TAR-deleted mutants of HIV-1 demonstrate normal late gene expression in glial cells as evidenced by syncytia formation and production of viral p24 antigen.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observe	observe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	TAR	Tar	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
26	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	p24	p24	NOUN	NN	Number=Sing	_	_	_	_
32	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1560
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1561
# text = Document 00300156 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300156	00300156	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1562
# text = Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha.
1	Biphasic	Biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1563
# text = The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	/CD3	/CD3	NUM	CD	NumType=Card	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
33	times	time	NOUN	NNS	Number=Plur	_	_	_	_
34	after	after	ADP	IN	_	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1564
# text = Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells.
1	Only	only	ADV	RB	_	_	_	_	_
2	p50	p50	NUM	CD	NumType=Card	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	bound	bound	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2R	2r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	SCONJ	IN	_	_	_	_	_
27	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1565
# text = However, immediately after TcR/CD3 cross-linking (after approximately 1 h; immediate) binding of p50.p65 heterodimers was observed.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immediately	immediately	ADV	RB	_	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	TcR/	TcR/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
7	cross-linking	cross-linking	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	after	after	ADP	IN	_	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p50.p65	p50.p65	NOUN	NN	Number=Sing	_	_	_	_
19	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	observed	observed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1566
# text = p50.c-rel heterodimers were also detected bound to this sequence at early time points (7-16 h; early), and both remained active at later time points (40 h; late) after activation.
1	p50.c	p50.c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-rel	-rel	ADJ	JJ	Degree=Pos	_	_	_	_
3	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	_
14	points	point	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	16	16	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	early	early	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	both	both	ADV	RB	_	_	_	_	_
26	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
30	time	time	NOUN	NN	Number=Sing	_	_	_	_
31	points	point	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	40	40	NUM	CD	NumType=Card	_	_	_	_
34	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	after	after	ADP	IN	_	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1567
# text = This regulation takes place mainly at the level of nuclear translocation of p65 and c-rel, at immediate and early time points.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	takes	take	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	place	place	NOUN	NN	Number=Sing	_	_	_	_
5	mainly	mainly	ADV	RB	_	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	time	time	NOUN	NN	Number=Sing	_	_	_	_
23	points	point	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1568
# text = Activation also induced c-rel and p105/p50 mRNA synthesis, but not p65 mRNA whose expression was constitutive.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	p65	p65	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
17	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1569
# text = Interestingly, all those early and late events, but not the immediate ones, were inhibited by a neutralizing anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
14	ones	one	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	neutralizing	neutralize	NOUN	NN	Number=Sing	_	_	_	_
21	anti-tumor	anti-tumor	ADP	IN	_	_	_	_	_
22	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
31	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1570
# text = Similarly, cycloheximide prevented the p65 and c-rel translocation and consequent formation of active binding heterodimers, at early and late times.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
4	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
23	times	time	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1571
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1572
# text = A impaired not only early and late, but also immediate events; however, addition of TNF-alpha prevented all inhibition.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
3	not	not	ADV	RB	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
21	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	all	all	DET	DT	_	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1573
# text = These results indicate that the regulation of NF-kappa B activation during T cell activation by TcR/CD3 signals is biphasic: TcR/CD3 triggers its immediate translocation, which is transient if no TNF-alpha is present.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TcR/CD3	TcR/CD3	NUM	CD	NumType=Card	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	biphasic	biphasic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	TcR/CD3	TcR/CD3	NUM	CD	NumType=Card	_	_	_	_
24	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
27	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	transient	transient	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	if	if	SCONJ	IN	_	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1574
# text = TNF-alpha, therefore, emerges as the main factor responsible for a second phase of NF-kappa B regulation, controlling both translocation of p65 and c-rel, and new mRNA synthesis for c-rel and p105/p50.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	emerges	emerge	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	p65	p65	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
35	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
36	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1575
# text = Document 00300157 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300157	00300157	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1576
# text = Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	post	post	X	AFX	_	_	_	_	SpaceAfter=No
4	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1577
# text = AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
31	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
37	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
38	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1578
# text = We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1579
# text = Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA.
1	Low	low	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
11	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	reached	reach	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	near	near	ADP	IN	_	_	_	_	_
26	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	24	24	NUM	CD	NumType=Card	_	_	_	_
30	h	h	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	32	32	NUM	CD	NumType=Card	_	_	_	_
35	nM	nM	PROPN	NNP	Number=Sing	_	_	_	_
36	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1580
# text = Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	937	937	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1581
# text = Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	bryostatin	bryostatin	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	nM	nm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	another	another	DET	DT	_	_	_	_	_
14	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C	c	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1582
# text = Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
6	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	structurally	structurally	ADV	RB	_	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	60	60	NUM	CD	NumType=Card	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1583
# text = TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts.
1	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	60	60	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	superinduction	superinduction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1584
# text = Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold.
1	Run	run	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	on	on	ADP	IN	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
15	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	60	60	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
25	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
28	3.3	3.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1585
# text = Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1586
# text = The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	life	life	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
8	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
9	as	as	ADV	RB	_	_	_	_	_
10	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	60	60	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	actinomycin	actinomycin	PROPN	NNP	Number=Sing	_	_	_	_
21	D	d	PROPN	NNP	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	30	30	NUM	CD	NumType=Card	_	_	_	_
24	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1587
# text = In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	life	life	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
11	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	60	60	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	cycloheximide	cycloheximide	VERB	VB	VerbForm=Inf	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	actinomycin	actinomycin	VERB	VB	VerbForm=Inf	_	_	_	_
25	D	d	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1588
# text = These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
10	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
11	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	post	post	X	AFX	_	_	_	_	SpaceAfter=No
25	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1589
# text = Document 00300158 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300158	00300158	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1590
# text = Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1591
# text = The T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
6	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
7	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	APCs	APC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	playing	play	VERB	VBG	VerbForm=Ger	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	Ags	ag	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1592
# text = Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	incomplete	incomplete	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1593
# text = In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1594
# text = In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	CD5	CD5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	CD7	CD7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	only	only	ADV	RB	_	_	_	_	_
37	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1595
# text = CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium.
1	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	C	c	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1596
# text = Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1597
# text = A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	whereby	whereby	ADP	IN	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	junB	junb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	members	member	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
25	inappropriate	inappropriate	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
41	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
42	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1598
# text = Document 00300159 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300159	00300159	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1599
# text = Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.
1	Antioxidants	Antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
2	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
28	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1600
# text = Cell adhesion to endothelial cells stimulated by tumor necrosis factor-alpha (TNF) is due to induction of surface receptors, such as vascular cell adhesion molecule-1 (VCAM-1).
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
29	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1601
# text = The antioxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-kappa B (NF-kappa B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
3	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
4	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1602
# text = Since kappa B motifs are present in VCAM-1 and intercellular adhesion molecule-1 (ICAM-1) promoters, we used PDTC to study the regulatory mechanisms of VCAM-1 and ICAM-1 induction and subsequent monocyte adhesion in TNF-treated human umbilical vein endothelial cells (HUVECs).
1	Since	since	ADP	IN	_	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
43	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
44	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
50	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
51	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
52	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1603
# text = PDTC or N-acetylcysteine dose dependently reduced TNF-induced VCAM-1 but not ICAM-1 surface protein (also in human umbilical arterial endothelial cells) and mRNA expression (by 70% at 100 mumol/L PDTC) in HUVECs as assessed by flow cytometry and polymerase chain reaction.
1	PDTC	Pdtc	NOUN	NN	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	_
5	dose	dose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	dependently	dependently	ADV	RB	_	_	_	_	_
7	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	also	also	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
26	arterial	arterial	NOUN	NN	Number=Sing	_	_	_	_
27	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	by	by	ADP	IN	_	_	_	_	_
35	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	%	%	SYM	NN	Number=Sing	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	100	100	NUM	CD	NumType=Card	_	_	_	_
39	mumol/L	mumol/L	PROPN	NNP	Number=Sing	_	_	_	_
40	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	HUVECs	Huvecs	PROPN	NNP	Number=Sing	_	_	_	_
44	as	as	SCONJ	IN	_	_	_	_	_
45	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
48	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
51	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
52	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1604
# text = Gel-shift analysis in HUVECs demonstrated that PDTC prevented NF-kappa B mobilization by TNF, suggesting that only VCAM-1 induction was controlled by NF-kappa B.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1605
# text = Since HUVECs released superoxide anions in response to TNF, and H2O2 induces VCAM-1, PDTC may act as a radical scavenger.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
3	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
5	anions	anion	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
13	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
14	VCAM	VCAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
24	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1606
# text = Although ICAM-1 induction was unaffected, inhibitors of NADPH oxidase (apocynin) or cytochrome P-450 (SKF525a) suppressed VCAM-1 induction by TNF, revealing that several radical-generating systems are involved in its regulation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NADPH	NADPH	DET	DT	_	_	_	_	_
12	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	apocynin	apocynin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	cytochrome	cytochrome	NOUN	NN	Number=Sing	_	_	_	_
18	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	450	450	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	SKF	SKF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	525	525	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
36	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	generating	generating	NOUN	NN	Number=Sing	_	_	_	_
39	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
44	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1607
# text = PDTC, apocynin, or SKF525a decreased adhesion of monocytic U937 cells to TNF-treated HUVECs (by 75% at 100 mumol/L PDTC).
1	PDTC	Pdtc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apocynin	apocynin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	SKF	SKF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	52	52	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	by	by	ADP	IN	_	_	_	_	_
23	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	100	100	NUM	CD	NumType=Card	_	_	_	_
27	mumol	mumol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/L	/L	PROPN	NNP	Number=Sing	_	_	_	_
29	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1608
# text = Inhibition by anti-VCAM-1 monoclonal antibody 1G11 indicated that U937 adhesion was VCAM-1 dependent and suppression by antioxidants was due to reduced VCAM-1 induction.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	anti-VCAM	anti-vcam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
8	1G11	1G11	PROPN	NNP	Number=Sing	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	VCAM	Vcam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	dependent	dependent	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1609
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1610
# text = Document 00300160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300160	00300160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1611
# text = Reduction of tumour necrosis factor alpha expression and signalling in peripheral blood mononuclear cells from patients with thalassaemia or sickle cell anaemia upon treatment with desferrioxamine.
1	Reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	thalassaemia	thalassaemia	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	sickle	sickle	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	anaemia	anaemia	NOUN	NN	Number=Sing	_	_	_	_
23	upon	upon	ADP	IN	_	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	desferrioxamine	desferrioxamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1612
# text = Recent evidence indicates that the rate of progression of the HIV-1 disease is significantly reduced in thalassaemia major patients upon treatment with high doses of desferrioxamine (DFX).
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	thalassaemia	thalassaemia	NOUN	NN	Number=Sing	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
26	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	desferrioxamine	desferrioxamine	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	DFX	DFX	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1613
# text = The authors have previously demonstrated that in vitro exposure of mononuclear cells to DFX decreases the bioavailability of tumour necrosis factor alpha (TNF-alpha) which has a stimulatory effect on HIV-1 replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	authors	author	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
9	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	DFX	DFX	PROPN	NNP	Number=Sing	_	_	_	_
15	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	on	on	ADP	IN	_	_	_	_	_
34	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1614
# text = In this study, therefore, TNF-alpha bioavailability from mononuclear cells isolated from 10 patients with thalassaemia or sickle cell anaemia given DFX as compared to 10 untreated subjects has been evaluated.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	thalassaemia	thalassaemia	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	anaemia	anaemia	ADP	IN	_	_	_	_	_
24	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	DFX	Dfx	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
31	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
32	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1615
# text = Evidence is presented showing that DFX treatment reduces TNF-alpha bioavailability (P<0.05) by inhibiting its steady state (P<0.05) and by enhancing its inactivation through binding to soluble TNF-alpha receptor type II (P<0.05).
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	DFX	DFX	PROPN	NNP	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
22	state	state	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
33	through	through	SCONJ	IN	_	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	soluble	soluble	VERB	VB	VerbForm=Inf	_	_	_	_
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
40	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
41	type	type	NOUN	NN	Number=Sing	_	_	_	_
42	II	ii	NUM	CD	NumType=Card	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1616
# text = We also show that DFX treatment limits the in vivo activation of NF-kappaB, a transcription factor involved in both TNF-alpha gene transcription and TNF-alpha signalling (P<0.005).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DFX	DFX	PROPN	NNP	Number=Sing	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	limits	limit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	0.005	0.005	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1617
# text = We conclude that TNF-alpha bioavailability and signalling are impaired in patients upon DFX treatment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	DFX	Dfx	ADJ	JJ	Degree=Pos	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1618
# text = This mechanism may contribute to delayed progression of the HIV-1 infection in vivo.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	delayed	delayed	VERB	VB	VerbForm=Inf	_	_	_	_
7	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1619
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1620
# text = Document 00300161 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300161	00300161	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1621
# text = Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins.
1	Heterodimerization	Heterodimerization	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1622
# text = The NF-kappa B family of transcription proteins represents multiple DNA binding, rel related polypeptides that contribute to regulation of genes involved in immune responsiveness and inflammation, as well as activation of the HIV long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	rel	rel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
16	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
17	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
27	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	as	as	ADV	RB	_	_	_	_	_
32	well	well	ADV	RB	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
38	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
39	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
40	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1623
# text = In this study multiple NF-kappa B related polypeptides ranging from 85 to 45 kDa were examined for their capacity to interact with the PRDII regulatory element of interferon beta and were shown to possess distinct intrinsic DNA binding affinities for this NF-kappa B site and form multiple DNA binding homo- and heterodimer complexes in co-renaturation experiments.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
10	polypeptides	polypeptides	NOUN	NNS	Number=Plur	_	_	_	_
11	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	85	85	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	45	45	NUM	CD	NumType=Card	_	_	_	_
16	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PRDII	pRDIi	X	AFX	_	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	possess	possess	VERB	VB	VerbForm=Inf	_	_	_	_
37	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
38	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	site	site	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	form	form	ADJ	JJ	Degree=Pos	_	_	_	_
51	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
52	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
53	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
54	homo	homo	ADV	RB	_	_	_	_	SpaceAfter=No
55	-	-	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
58	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	co-renaturation	co-renaturation	NOUN	NN	Number=Sing	_	_	_	_
61	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1624
# text = Furthermore, using DNA templates containing two copies of the PRDII domain linked to the rabbit beta globin gene, the purified polypeptides specifically stimulated NF-kappa B dependent transcription in an in vitro reconstitution assay as heterodimers but not as p50 homodimers.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	templates	template	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	PRDII	PRDII	PROPN	NNP	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	globin	globin	ADP	IN	_	_	_	_	_
19	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
24	specifically	specifically	ADV	RB	_	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
36	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	_
37	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	not	not	ADV	RB	_	_	_	_	_
42	as	as	ADV	RB	_	_	_	_	_
43	p50	p50	NUM	CD	NumType=Card	_	_	_	_
44	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1625
# text = These experiments emphasize the role of NF-kappa B dimerization as a distinct level of transcriptional control that may permit functional diversification of a limited number of regulatory proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	permit	permit	VERB	VB	VerbForm=Inf	_	_	_	_
22	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
23	diversification	diversification	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
27	number	number	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1626
# text = Document 00300162 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300162	00300162	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1627
# text = A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B. Activation of T cells by antigen, lectin, or a combination of phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) leads to the induction of genes for a set of lymphokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
36	line	line	NOUN	NN	Number=Sing	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
46	Activation	Activation	PROPN	NNP	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	T	t	PROPN	NNP	Number=Sing	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	or	or	CCONJ	CC	_	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
64	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
70	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
71	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
72	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
73	)	)	PUNCT	-RRB-	_	_	_	_	_
74	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
75	to	to	ADP	IN	_	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
78	of	of	ADP	IN	_	_	_	_	_
79	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
80	for	for	ADP	IN	_	_	_	_	_
81	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
82	set	set	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	lymphokines	lymphokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
87	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
90	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
93	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
94	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
95	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
96	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
97	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
98	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
99	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1628
# text = We demonstrated in earlier studies that the upstream region of the mouse GM-CSF promoter at positions between -95 and -73 is essential for transcriptional activation in response to PMA/A23187.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	-95	-95	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	73	73	NUM	CD	NumType=Card	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	PMA/A	PMA/A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	23187	23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1629
# text = This region contains two DNA-binding motifs, GM2 and GC-box.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	GM2	GM2	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	GC	Gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1630
# text = The GM2 sequence (GGTAGTTCCC) is recognized by an inducible factor NF-GM2; the other (CCGCCC) by constitutive factors A1, A2, and B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM2	Gm2	NUM	CD	NumType=Card	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GGTAGTTCCC	GGTAGTTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	CCGCCC	CCGCCC	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	A1	A1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	A2	A2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1631
# text = To elucidate the mechanism of GM-CSF gene activation, we have purified the inducible factor NF-GM2 from the nuclear extract of stimulated Jurkat cells on the basis of specific DNA-binding activity.
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1632
# text = The purified NF-GM2 consists of 50 (p50) and 65 kDa (p65) polypeptides and has a binding activity specific for both the GM-CSF and immunoglobulin kappa (GGAAAGTCCC) enhancers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
6	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	65	65	NUM	CD	NumType=Card	_	_	_	_
14	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	GM	gm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	Csf	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	immunoglobulin	immunoglobulin	PROPN	NNP	Number=Sing	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	GGAAAGTCCC	Ggaaagtccc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1633
# text = Electrophoretically purified p50 alone can form a protein-DNA complex, but in the mixture, p50 associates preferentially with p65 to form the NF-GM2 complex.
1	Electrophoretically	Electrophoretically	ADV	RB	_	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
4	alone	alone	ADV	RB	_	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	_
19	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
20	preferentially	preferentially	ADV	RB	_	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1634
# text = In addition, p65 gave per se, with low affinity, a protein-DNA complex that migrated more slowly than native NF-GM2 complex.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	p65	p65	NUM	CD	NumType=Card	_	_	_	_
5	gave	give	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	per	per	ADP	IN	_	_	_	_	_
7	se	se	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	migrated	migrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	slowly	slowly	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	GM2	Gm2	NUM	CD	NumType=Card	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1635
# text = Furthermore, an antiserum against KBF1 (identical to 50 kDa NF-kappa B protein) reacted with the p50 of NF-GM2, indicating that the NF-GM2 polypeptide cannot be immunologically differentiated from the 50 kDa subunit of NF-kappa B.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
5	against	against	ADP	IN	_	_	_	_	_
6	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	50	50	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	X	GW	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	reacted	react	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
33	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
35	not	not	PART	RB	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	immunologically	immunologically	ADV	RB	_	_	_	_	_
38	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	50	50	NUM	CD	NumType=Card	_	_	_	_
42	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
43	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
48	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1636
# text = The purified NF-GM2 activated in vitro transcription from the kappa B enhancer, while it failed to stimulate transcription from the GM-CSF promoter harboring the GM2 sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	harboring	harbor	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1637
# text = This suggests that the activation mechanism of the GM-CSF gene through the GM2/GC-box sequence is different from that of genes carrying the kappa B enhancer alone.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM2/GC	Gm2/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1638
# text = Document 00300163 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300163	00300163	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1639
# text = Retinoic acid-induced modulation of IL-2 mRNA production and IL-2 receptor expression on T cells.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1640
# text = BACKGROUND: Retinoic acid (RA) has important immune-modulating effects on both T and B cell function.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
4	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-modulating	-modulating	NOUN	NN	Number=Sing	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1641
# text = Our laboratory has shown that RA can enhance in vitro polyclonal B cell immunoglobulin
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
11	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1642
# text = (Ig) response.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1643
# text = Investigating cytokines known to affect B cell differentiation, we have recently shown that IL-6 production is augmented by RA.
1	Investigating	investigate	VERB	VBG	VerbForm=Ger	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	affect	affect	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1644
# text = In the present study we have examined the immune modulating effects of RA on IL-2 mRNA, another important cytokine for B cell immunoglobulin production, the expression of IL-2 receptors on T cells, and the RA nuclear receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	modulating	modulating	NOUN	NN	Number=Sing	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	another	another	DET	DT	_	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1645
# text = METHODS: Purified T cells were obtained from adenoidal tissues, and incubated with RA (10(-7) M) or DMSO solvent/media control for 0, 6-8, and 24 h.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	adenoidal	adenoidal	ADJ	JJ	Degree=Pos	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
19	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	_
25	solvent	solvent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	media	media	NOUN	NN	Number=Sing	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	24	24	NUM	CD	NumType=Card	_	_	_	_
38	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1646
# text = Total mRNA was extracted from T cells, and using RT-PCR, changes in the production of IL-2 and RA receptors (RAR)-alpha,beta,gamma mRNA were determined.
1	Total	total	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
11	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	PCR	Pcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
34	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
35	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1647
# text = The effects of RA on IL-2-alpha receptor expression was determined by flow cytometry on T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
17	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1648
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1649
# text = These studies suggest that RA can augment IL-2 mRNA production by T cells with a possible paracrine effect on IL-2R-alpha expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
19	paracrine	paracrine	NOUN	NN	Number=Sing	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	IL-	IL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	2R	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1650
# text = These changes appear to be mediated by RAR-alpha.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	RAR-	rar-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1651
# text = Thus, IL-2 may be another important cytokine modulated by RA in the immune response.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	another	another	DET	DT	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1652
# text = Document 00300164 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300164	00300164	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1653
# text = IL-1 receptor and TCR signals synergize to activate NF-kappa B-mediated gene transcription.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1654
# text = Previous studies have demonstrated that IL-1 receptor (IL-1R)- and TCR-initiated signals can interact synergistically to increase the rate of transcription of several lymphokine and lymphokine receptor genes during the competence phase of the activation program in T helper lymphocytes.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1R	-1r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
22	synergistically	synergistically	ADV	RB	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	competence	competence	NOUN	NN	Number=Sing	_	_	_	_
39	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	program	program	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
47	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1655
# text = In this report we describe how signals initiated through the type I IL-1R interact with signals from the antigen receptor to synergistically augment the transactivating properties of NF-kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	how	how	ADV	WRB	PronType=Int	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1R	1r	PROPN	NNP	Number=Sing	_	_	_	_
16	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	synergistically	synergistically	ADV	RB	_	_	_	_	_
25	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1656
# text = The synergistic antigen receptor initiated signals are mediated through protein kinase C because they can be mimicked by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, but not with calcium ionophores; and are staurosporine sensitive but cyclosporine resistant.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
3	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	C	care	NOUN	NN	Number=Sing	_	_	_	_
13	because	because	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	O	o	INTJ	UH	_	_	_	_	SpaceAfter=No
26	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
27	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
34	ionophores	ionophore	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	staurosporine	staurosporine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	cyclosporine	cyclosporine	ADJ	JJ	Degree=Pos	_	_	_	_
42	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1657
# text = Gel shift analyses demonstrate that NF-kappa B nuclear translocation is stimulated primarily by IL-1 rather than by antigen receptor signals.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	primarily	primarily	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	rather	rather	ADV	RB	_	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	antigen	antigen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1658
# text = Western blot and phosphorylation analyses demonstrate that the synergistic effect on NF-kappa B functional activity is independent of I kappa B alpha (MAD3)-NF-kappa B dissociation in the cytosol and is not associated with I kappa B nuclear translocation.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
43	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
45	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
46	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1659
# text = The IL-1-induced NF-kappa B DNA nuclear localization is transient and can be prolonged either by an antigen receptor-initiated signal or by inhibiting protein synthesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	dna	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	either	either	CCONJ	CC	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-initiated	-initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	by	by	SCONJ	IN	_	_	_	_	_
29	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1660
# text = These results suggest that IL-1 induces both NF-kappa B nuclear translocation and the synthesis of a protein(s) responsible for terminating NF-kappa B-DNA interaction in the nucleus.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	s	s	X	AFX	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	terminating	terminating	VERB	VBG	VerbForm=Ger	_	_	_	_
28	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1661
# text = Antigen receptor signals prolong NF-kappa B-DNA interaction, probably by functionally antagonizing the IL-1-induced synthesis of a protein(s) responsible for the transient NF-kappa B-DNA interaction and consequently synergistically enhance IL-1-induced NF-kappa B-dependent gene transcription.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	prolong	prolong	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	probably	probably	ADV	RB	_	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	functionally	functionally	ADV	RB	_	_	_	_	_
16	antagonizing	antagonize	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	s	s	X	AFX	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	consequently	consequently	ADV	RB	_	_	_	_	_
43	synergistically	synergistically	ADV	RB	_	_	_	_	_
44	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
45	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
53	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
57	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1662
# text = Document 00300165 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300165	00300165	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1663
# text = Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	AT	at	ADP	IN	_	_	_	_	SpaceAfter=No
6	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1664
# text = Activation of individual CD4+ T cells results in differential lymphokine expression: interleukin 2 (IL-2) is preferentially produced by T helper type 1 (TH1) cells, which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells, which are essential for humoral immunity.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	preferentially	preferentially	ADV	RB	_	_	_	_	_
23	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TH1	TH1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
42	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	whereas	whereas	SCONJ	IN	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	4	4	NUM	CD	NumType=Card	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	TH2	TH2	NUM	CD	NumType=Card	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	which	which	PRON	WDT	PronType=Rel	_	_	_	_
55	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	humoral	humoral	ADJ	JJ	Degree=Pos	_	_	_	_
59	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1665
# text = The Ca(2+)-dependent factor NF-ATp plays a key role in the inducible transcription of both these lymphokine genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1666
# text = However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C-dependent signals, we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	IL2	IL2	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+)	+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C-	C-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	IL4	IL4	NUM	CD	NumType=Card	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	through	through	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
44	C	c	NOUN	NN	Number=Sing	_	_	_	_
45	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
48	T	t	PROPN	NNP	Number=Sing	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1667
# text = This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence, an element located 69 bp upstream of the IL4 transcription initiation site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	due	due	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	mutually	mutually	ADV	RB	_	_	_	_	_
7	exclusive	exclusive	VERB	VB	VerbForm=Inf	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	P	P	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	69	69	NUM	CD	NumType=Card	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL4	IL4	PROPN	NNP	Number=Sing	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1668
# text = Human IL4 promoter-mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B-activating cytokine tumor necrosis factor alpha and suppressed in RelA-overexpressing cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	IL4	IL4	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	overexpressing	overexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1669
# text = In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence, which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	C	NOUN	NN	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	IL4	Il4	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	P	p	NOUN	NN	Number=Sing	_	_	_	_
25	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1670
# text = Thus, competition between two general transcriptional activators, RelA and NF-ATp, mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	C	c	NOUN	NN	Number=Sing	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	IL4	IL4	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	differential	differential	VERB	VB	VerbForm=Inf	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	TH	th	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1671
# text = Document 00300166 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300166	00300166	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1672
# text = Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	S	S	NOUN	NN	Number=Sing	_	_	_	_
18	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1673
# text = It is becoming increasingly apparent that NF-kappa B plays a critical role in regulating the inflammatory response.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	becoming	become	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	increasingly	increasingly	ADV	RB	_	_	_	_	_
5	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1674
# text = Data obtained from studies in our laboratories demonstrate that the proteasome plays an important role in the inflammatory cascade by regulating the activation of NF-kappa B.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
7	laboratories	laboratory	NOUN	NNS	Number=Plur	_	_	_	_
8	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1675
# text = Indeed, the availability of selective and orally active proteasome inhibitors should prove useful in delineating the roles of the proteasome and NF-kappa B in other pathophysiological conditions such as cancer and heart disease.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	orally	orally	ADV	RB	_	_	_	_	_
9	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
13	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
14	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	delineating	delineat	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathophysiological	pathophysiological	ADJ	JJ	Degree=Pos	_	_	_	_
30	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
31	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	heart	heart	NOUN	NN	Number=Sing	_	_	_	_
36	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1676
# text = Document 00300167 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300167	00300167	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1677
# text = HIV1 infection of human monocytes and macrophages promotes induction or translocation of NF-KB-related factors.
1	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	KB	KB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1678
# text = In 1991, we demonstrated, using electrophoretic mobility shift assays, that 3 different factors (termed B1, B2 and B3) with affinity for the KB-enhancer target sequence were specifically detected in nuclear extracts from HIV1-infected monocytes and macrophages.
1	In	in	ADP	IN	_	_	_	_	_
2	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
9	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
10	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
11	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	B1	b1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	B2	b2	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	B3	B3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	KB	KB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	target	target	NOUN	NN	Number=Sing	_	_	_	_
33	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	specifically	specifically	ADV	RB	_	_	_	_	_
36	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1679
# text = The B2 factor was induced in the nuclei of these cells only upon HIV1 infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B2	b2	NUM	CD	NumType=Card	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1680
# text = The B3 factor was only slightly evident in nuclei of uninfected cells but was readily detectable in nuclei of infected monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B3	B3	NUM	CD	NumType=Card	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	slightly	slightly	ADV	RB	_	_	_	_	_
7	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	readily	readily	ADV	RB	_	_	_	_	_
16	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1681
# text = Its expression remained very low in nuclei of HIV1-infected macrophages.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	very	very	ADV	RB	_	_	_	_	_
5	low	low	ADV	RB	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1682
# text = In this paper, we demonstrate that the B2 factor is expressed in the cytosol of monocytes and macrophages as a DNA-binding protein, indicating that it is not associated with an inhibitor (IKB).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IKB	IKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1683
# text = This factor remained clustered in the cytosol and was translocated to the nuclei only after HIV1 infection.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	clustered	cluster	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1684
# text = The B3 factor is detected in the cytosol only when cells are HIV1-infected.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B3	B3	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1685
# text = The role of HIV1 infection in the expression and the translocation of these factors is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1686
# text = Document 00300168 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300168	00300168	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1687
# text = The intracellular parasite Theileria parva protects infected T cells from apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
4	Theileria	Theileria	NOUN	NN	Number=Sing	_	_	_	_
5	parva	parva	NOUN	NN	Number=Sing	_	_	_	_
6	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1688
# text = Parasites have evolved a plethora of strategies to ensure their survival.
1	Parasites	Parasite	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evolved	evolve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	plethora	plethora	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	ensure	ensure	VERB	VB	VerbForm=Inf	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1689
# text = The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting and transforming T cells, inducing their continuous proliferation and rendering them metastatic.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
4	Theileria	Theileria	NOUN	NN	Number=Sing	_	_	_	_
5	parva	parva	NOUN	NN	Number=Sing	_	_	_	_
6	secures	secure	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	propagation	propagation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	spreads	spread	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	infecting	infecte	VERB	VBG	VerbForm=Ger	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	rendering	render	VERB	VBG	VerbForm=Ger	_	_	_	_
28	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1690
# text = In previous work, we have shown that the parasite induces constitutive activation of the transcription factor NF-kappaB, by inducing the constitutive degradation of its cytoplasmic inhibitors.
1	In	in	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
11	induces	induces	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1691
# text = The biological significance of NF-kappaB activation in T.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
3	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1692
# text = parva-infected cells, however, has not yet been defined.
1	parva-infected	parva-infected	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	yet	yet	ADV	RB	_	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1693
# text = Cells that have been transformed by viruses or oncogenes can persist only if they manage to avoid destruction by the apoptotic mechanisms that are activated on transformation and that contribute to maintain cellular homeostasis.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	viruses	virus	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	persist	persist	VERB	VB	VerbForm=Inf	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	if	if	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	manage	manage	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	avoid	avoid	VERB	VB	VerbForm=Inf	_	_	_	_
18	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
33	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1694
# text = We now demonstrate that parasite-induced NF-kappaB activation plays a crucial role in the survival of T. parva-transformed
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
21	parva	parva	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 1695
# text = T cells by conveying protection against an apoptotic signal that accompanies parasite-mediated transformation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	conveying	convey	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	accompanies	accompany	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1696
# text = Consequently, inhibition of NF-kappaB nuclear translocation and the expression of dominant negative mutant forms of components of the NF-kappaB activation pathway, such as IkappaBalpha or p65, prompt rapid apoptosis of T. parva-transformed
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
15	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
16	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
17	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	components	component	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	prompt	prompt	ADJ	JJ	Degree=Pos	_	_	_	_
35	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
36	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
39	parva	parva	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 1697
# text = T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1698
# text = Our findings offer important insights into parasite survival strategies and demonstrate that parasite-induced constitutive NF-kappaB activation is an essential step in maintaining the transformed phenotype of the infected cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	offer	offer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
8	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
9	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
24	step	step	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	SCONJ	IN	_	_	_	_	_
26	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1699
# text = Document 00300169 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300169	00300169	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1700
# text = Posttranscriptional regulation of macrophage tissue factor expression by antioxidants.
1	Posttranscriptional	Posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1701
# text = Tissue factor (TF) expression by cells of monocyte/macrophage lineage represents an important mechanism underlying the initiation of fibrin deposition at sites of extravascular inflammation.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
13	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
14	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	fibrin	fibrin	NOUN	NN	Number=Sing	_	_	_	_
23	deposition	deposition	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	extravascular	extravascular	ADJ	JJ	Degree=Pos	_	_	_	_
28	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1702
# text = Recent evidence suggests a role for oxidant stress in the signalling pathway of various cell types by virtue of its ability to induce DNA binding of various transcription factors, including nuclear factor kappa B and AP-1.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
8	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	signalling	signall	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1703
# text = The effect of antioxidant treatment on lipopolysaccharide (LPS)-induced TF expression was examined in murine peritoneal macrophages and human monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	murine	murine	PRON	PRP	_	_	_	_	_
19	peritoneal	peritoneal	ADJ	JJ	Degree=Pos	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1704
# text = Both pyrrolidine dithiocarbamate, an oxidant scavenger, and N-acetyl-cysteine, a precursor of the endogenous antioxidant glutathione, inhibited stimulation of macrophage procoagulant activity by LPS.
1	Both	both	DET	DT	_	_	_	_	_
2	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
3	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
7	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
20	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
21	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
27	procoagulant	procoagulant	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1705
# text = Northern blot analysis showed that neither of these agents reduced LPS-stimulated TF mRNA accumulation, thereby suggesting a posttranscriptional mechanism for the effect.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	neither	neither	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
10	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	thereby	thereby	ADV	RB	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1706
# text = Immunofluorescence studies of human monocytes using polyclonal anti-TF antibody showed that N-acetyl-cysteine treatment prevented the characteristic plasmalemmal localization of TF antigen that occurs in response to LPS.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-TF	-tf	PROPN	NNP	Number=Sing	_	_	_	_
10	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
21	plasmalemmal	plasmalemmal	NOUN	NN	Number=Sing	_	_	_	_
22	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
25	antigen	antigen	VERB	VB	VerbForm=Inf	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1707
# text = Western blot analysis showed that N-acetyl-cysteine reduced the accumulation of the 47-kD mature glycoprotein in LPS-treated cells, a finding consistent with the results of the immunofluorescence studies.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
10	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
18	mature	mature	NOUN	NN	Number=Sing	_	_	_	_
19	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
28	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	results	result	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
35	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1708
# text = Furthermore, these conditions did not result in an accumulation of the less mature forms of TF.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	less	less	ADV	RBS	_	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1709
# text = When considered together, these data suggest that antioxidants exert their effects by impairing translation and/or by causing degradation of newly translated protein.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	data	data	NOUN	NN	Number=Sing	_	_	_	_
7	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
10	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	impairing	impair	VERB	VBG	VerbForm=Ger	_	_	_	_
15	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	or	or	CCONJ	CC	_	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
21	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	newly	newly	ADV	RB	_	_	_	_	_
24	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1710
# text = The effect of antioxidants on tumor necrosis factor appeared to be species specific, with no effect on LPS-induced tumor necrosis factor in murine cells, but with inhibition in human monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	species	species	NOUN	NNS	Number=Plur	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1711
# text = The posttranscriptional effect of antioxidants on TF expression data suggests a novel mechanism whereby these agents might modulate monocyte/macrophage activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	data	data	NOUN	NN	Number=Sing	_	_	_	_
10	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	whereby	whereby	SCONJ	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
19	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1712
# text = Document 00300170 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300170	00300170	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1713
# text = Natural variants of the HIV-1 long terminal repeat: analysis of promoters with duplicated DNA regulatory motifs.
1	Natural	Natural	ADJ	JJ	Degree=Pos	_	_	_	_
2	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
9	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
10	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	duplicated	duplicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1714
# text = Sequence variation in the long terminal repeat (LTR) region of HIV-1 was analyzed in viral isolates of 17 infected individuals.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
6	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
7	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	17	17	NUM	CD	NumType=Card	_	_	_	_
23	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1715
# text = Two classes of LTR size variants were found.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
5	size	size	NOUN	NN	Number=Sing	_	_	_	_
6	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1716
# text = One HIV-1 variant was detected containing an additional binding site for the transcription factor Sp1. Another LTR size variation was observed in four patients in a region just upstream of the NF-kappa B enhancer.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_
19	Another	another	DET	DT	_	_	_	_	_
20	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
21	size	size	NOUN	NN	Number=Sing	_	_	_	_
22	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	four	four	NUM	CD	NumType=Card	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	region	region	NOUN	NN	Number=Sing	_	_	_	_
31	just	just	ADV	RB	_	_	_	_	_
32	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1717
# text = This variation was the result of a duplication of a short DNA sequence (CTG-motif).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	result	result	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	duplication	duplication	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CTG-motif	CTG-motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1718
# text = Cell culture experiments demonstrated that the natural variant with four Sp1 sites had a slightly higher promoter activity and viral replication rate than the isogenic control LTR with three Sp1 sites.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
8	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	four	four	NUM	CD	NumType=Card	_	_	_	_
11	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	slightly	slightly	ADV	RB	_	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	isogenic	isogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	_
30	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
31	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1719
# text = No positive effect of the duplicated CTG-motif could be detected.
1	No	no	DET	DT	_	_	_	_	_
2	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	duplicated	duplicate	ADJ	JJ	Degree=Pos	_	_	_	_
7	CTG-	Ctg-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1720
# text = In order to measure small differences in virus production more accurately, equal amounts of a size variant and the wild-type plasmid were cotransfected into T-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	measure	measure	VERB	VB	VerbForm=Inf	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	accurately	accurately	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	_
14	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	size	size	NOUN	NN	Number=Sing	_	_	_	_
18	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1721
# text = The virus with four Sp1 sites did outgrow the three Sp1 virus in 35 days of culture and CTG-monomer virus outcompeted the CTG-dimer virus in 42 days.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	four	four	NUM	CD	NumType=Card	_	_	_	_
5	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	outgrow	outgrow	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	35	35	NUM	CD	NumType=Card	_	_	_	_
15	days	day	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CTG-monomer	CTG-monomer	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	outcompeted	outcompete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CTG-	Ctg-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	42	42	NUM	CD	NumType=Card	_	_	_	_
28	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1722
# text = Based on these results we estimate a 5-10% difference in virus production of the LTR variants when compared to that of wild-type.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	estimate	estimate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
19	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1723
# text = Document 00300171 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300171	00300171	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1724
# text = Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	Nef	Nef	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	regulates	regulate	VERB	NNS	Number=Plur	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1725
# text = Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) has been shown to down-regulate the transcription factors NF-kappa B and AP-1 in vitro.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1726
# text = To define the mechanism of action of the Nef protein, the signal transduction pathways which may be affected in T cells by constitutive expression of the nef gene were examined.
1	To	to	PART	TO	_	_	_	_	_
2	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	action	action	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1727
# text = Stimulation of T cells with tumor necrosis factor, interleukin-1, or lipopolysaccharide resulted in the recruitment of transcriptional factors to a similar level whether or not the cells expressed the nef gene.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
16	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	whether	whether	SCONJ	IN	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nef	nef	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1728
# text = On the other hand, stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex resulted in the down-regulation of transcriptional factors NF-kappa B and AP-1 in cells expressing the nef gene compared with cells not expressing the nef gene.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	not	not	ADV	RB	_	_	_	_	_
52	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
55	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1729
# text = Because the Nef protein does not affect the surface expression of the CD3-TCR complex, we conclude that the Nef protein down-regulates the transcriptional factors NF-kappa B and AP-1 in T cells in vitro through an effect on the TCR-dependent signal transduction pathway.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
43	through	through	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
46	on	on	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
51	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
52	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
53	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1730
# text = Document 00300172 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300172	00300172	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1731
# text = Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	relA	relA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
10	B	b	X	LS	_	_	_	_	_
11	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1732
# text = We evaluated the expression and DNA binding activity of nuclear factor (NF)-kappa B subunits in human peripheral blood monocytes and in monocyte-derived macrophages (MDMs).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	MDMs	Mdms	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1733
# text = Constitutive DNA binding activity consisting of p50 homodimers was detected in nuclear extracts from both cell types.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	consisting	consisting	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	_
8	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1734
# text = An additional complex composed of p50/RelA(p65) heterodimers appeared only in nuclear extracts from 7-day MDMs.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
12	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	day	day	NOUN	NN	Number=Sing	_	_	_	_
21	MDMs	MDM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1735
# text = Immunoblot analysis showed that the p50 subunit was constitutively expressed in monocytes and MDMs.
1	Immunoblot	Immunoblot	PROPN	NNP	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	constitutively	constitutively	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	MDMs	MDM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1736
# text = In contrast, the RelA(p65) subunit was barely detectable in monocytes, but its level increased markedly in MDMs.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	barely	barely	ADV	RB	_	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	markedly	markedly	ADV	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1737
# text = Analysis of RelA(p65) mRNA revealed that the stability of RelA(p65) mRNA was significantly higher in MDMs, compared with monocytes.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1738
# text = In MDMs, an upregulation of I kappa
1	In	in	ADP	IN	_	_	_	_	_
2	MDMs	Mdms	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1739
# text = B alpha synthesis as well as the appearance of a novel M(r) 40,000 form of I kappa B alpha were also observed.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	40,000	40,000	NUM	CD	NumType=Card	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	B	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1740
# text = These results suggest that macrophage differentiation results in the expression of active p50/RelA(p65) heterodimers with the capacity to activate target gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	p50/	p50/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1741
# text = The parallel induction of I kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1742
# text = B alpha synthesis may allow for the continuous presence of a cytoplasmic reservoir of p50/RelA(p65) complexes that are readily available for inducer-mediated stimulation.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
13	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	p50/	p50/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	RelA	Rela	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	readily	readily	ADV	RB	_	_	_	_	_
24	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	inducer	inducer	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1743
# text = Document 00300173 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300173	00300173	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1744
# text = Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide.
1	Phosphatidylinositides	Phosphatidylinositides	NOUN	NNS	Number=Plur	_	_	_	_
2	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
11	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1745
# text = Although bacterial lipopolysaccharides (LPS) and several other microbial agonists can bind to mCD14 (membrane CD14), a cell-surface receptor found principally on monocytes and neutrophils, host-derived mCD14 ligands are poorly defined.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
3	lipopolysaccharides	lipopolysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
10	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
11	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	principally	principally	ADV	RB	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	mCD	mcd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	14	14	NUM	CD	NumType=Card	_	_	_	_
39	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	poorly	poorly	ADV	RB	_	_	_	_	_
42	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1746
# text = We report here that phosphatidylinositol (PtdIns), phosphatidylinositol-4-phosphate, and other phosphatidylinositides can bind to mCD14.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	phosphatidylinositides	phosphatidylinositide	NOUN	NNS	Number=Plur	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1747
# text = Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent affinity than does PtdIns.
1	Phosphatidylserine	Phosphatidylserine	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PS	ps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	another	another	DET	DT	_	_	_	_	_
7	anionic	anionic	ADJ	JJ	Degree=Pos	_	_	_	_
8	glycerophospholipid	glycerophospholipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
15	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
16	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	does	do	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1748
# text = LPS-binding protein, a lipid transfer protein found in serum, facilitates both PS- and PtdIns-mCD14 binding.
1	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
8	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	facilitates	facilitate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	PS	ps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PtdIns-	PtdIns-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	mCD14	mCD14	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1749
# text = PtdIns binding to mCD14 can be blocked by anti-CD14 monoclonal antibodies that inhibit LPS-mCD14 binding, and PtdIns can inhibit both LPS-mCD14 binding and LPS-induced responses in monocytes.
1	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	anti-CD	anti-cd	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	14	14	NUM	CD	NumType=Card	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mCD14	mcd14	NOUN	NN	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mCD14	mcd14	PROPN	NNP	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1750
# text = Serum-equilibrated PtdIns also binds to mCD14-expressing cells, raising the possibility that endogenous PtdIns may modulate cellular responses to LPS and other mCD14 ligands in vivo.
1	Serum-	Serum-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	equilibrated	equilibrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PtdIns	PtdIns	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-expressing	-expressing	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	raising	raise	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
19	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	mCD	mcd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	14	14	NUM	CD	NumType=Card	_	_	_	_
27	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1751
# text = Document 00300174 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300174	00300174	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1752
# text = The peri-kappa B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1753
# text = Human immunodeficiency virus type 2 (HIV-2), like HIV-1, causes AIDS and is associated with AIDS cases primarily in
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	like	like	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	AIDS	aid	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
24	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
25	primarily	primarily	ADV	RB	_	_	_	_	_
26	in	in	ADV	RB	_	_	_	_	_

# sent_id = 1754
# text = West Africa.
1	West	West	PROPN	NNP	Number=Sing	_	_	_	_
2	Africa	Africa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1755
# text = HIV-1 and HIV-2 display significant differences in nucleic acid sequence and in the natural history of clinical disease.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	display	display	NOUN	NN	Number=Sing	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nucleic	nucleic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
19	history	history	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1756
# text = Consistent with these differences, we have previously demonstrated that the enhancer/promoter region of HIV-2 functions quite differently from that of HIV-1.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	differences	difference	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
21	quite	quite	ADV	RB	_	_	_	_	_
22	differently	differently	ADV	RB	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1757
# text = Whereas activation of the HIV-1 enhancer following T-cell stimulation is mediated largely through binding of the transcription factor NF-kappa B to two adjacent kappa B sites in the HIV-1 long terminal repeat, activation of the HIV-2 enhancer in monocytes and T cells is dependent on four cis-acting elements: a single kappa B site, two purine-rich binding sites, PuB1 and PuB2, and a pets site.
1	Whereas	whereas	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	largely	largely	ADV	RB	_	_	_	_	_
16	through	through	ADV	RB	_	_	_	_	_
17	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
38	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
39	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	T	t	NOUN	NN	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
53	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
55	on	on	ADP	IN	_	_	_	_	_
56	four	four	NUM	CD	NumType=Card	_	_	_	_
57	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
59	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	:	:	PUNCT	:	_	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
63	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
64	B	b	NOUN	NN	Number=Sing	_	_	_	_
65	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	two	two	NUM	CD	NumType=Card	_	_	_	_
68	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
70	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
71	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
72	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
73	,	,	PUNCT	,	_	_	_	_	_
74	PuB1	Pub1	NOUN	NN	Number=Sing	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	PuB2	Pub2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	,	,	PUNCT	,	_	_	_	_	_
78	and	and	CCONJ	CC	_	_	_	_	_
79	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
80	pets	pet	NOUN	NN	Number=Sing	_	_	_	_
81	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1758
# text = We have now identified a novel cis-acting element within the HIV-2 enhancer, immediately upstream of the kappa B site, designated peri-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	immediately	immediately	ADV	RB	_	_	_	_	_
18	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1759
# text = This site is conserved among isolates of HIV-2 and the closely related simian immunodeficiency virus, and transfection assays show this site to mediate HIV-2 enhancer activation following stimulation of monocytic but not T-cell lines.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	among	among	ADP	IN	_	_	_	_	_
6	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	closely	closely	ADV	RB	_	_	_	_	_
14	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
15	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
22	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	ADV	RB	_	_	_	_	_
38	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1760
# text = This is the first description of an HIV-2 enhancer element which displays such monocyte specificity, and no comparable enhancer element has been clearly defined for HIV-1.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	description	description	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	no	no	DET	DT	_	_	_	_	_
21	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	clearly	clearly	ADV	RB	_	_	_	_	_
27	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1761
# text = While a nuclear factor(s) from both peripheral blood monocytes and T cells binds the peri-kappa B site, electrophoretic mobility shift assays suggest that either a different protein binds to this site in monocytes versus T cells or that the protein recognizing this enhancer element undergoes differential modification in monocytes and T cells, thus supporting the transfection data.
1	While	while	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	s	s	X	AFX	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
23	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
24	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
26	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	either	either	DET	DT	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	versus	versus	ADP	IN	_	_	_	_	_
39	T	T	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	that	that	SCONJ	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
46	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
48	element	element	NOUN	NN	Number=Sing	_	_	_	_
49	undergoes	undergo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
51	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	T	t	NOUN	NN	Number=Sing	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	thus	thus	ADV	RB	_	_	_	_	_
59	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
62	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1762
# text = Further, while specific constitutive binding to the peri-kappa B site is seen in monocytes, stimulation with phorbol esters induces additional, specific binding.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
21	induces	induce	ADV	RB	_	_	_	_	_
22	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1763
# text = Understanding the monocyte-specific function of the peri-kappa B factor may ultimately provide insight into the different role monocytes and T cells play in HIV pathogenesis.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	ultimately	ultimately	ADV	RB	_	_	_	_	_
13	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
14	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
26	pathogenesis	pathogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1764
# text = Document 00300175 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300175	00300175	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1765
# text = Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.
1	Suppressive	Suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1766
# text = BACKGROUND: Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60).
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
12	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
21	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
22	against	against	ADP	IN	_	_	_	_	_
23	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
24	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	60	60	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1767
# text = The interactions of Hsp60-specific
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1768
# text = T cells with arterial endothelial cells (EC) require expression of both Hsp60 and certain adhesion molecules shown to be induced simultaneously in EC by mechanical and other types of stress.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	arterial	arterial	ADJ	JJ	Degree=Pos	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	Hsp60	Hsp60	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	types	type	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1769
# text = Recently, it was shown that suppression of T cell-mediated immune responses by cyclosporin A (CyA) enhanced atherosclerotic lesion formation in mice.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
17	A	a	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
23	lesion	lesion	NOUN	NN	Number=Sing	_	_	_	_
24	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1770
# text = In contrast, aspirin was found to lower the risk of myocardial infarction in men.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	lower	lower	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
13	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	men	man	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1771
# text = These conflicting observations may be due to different effects of anti-inflammatory agents on adhesion molecule and Hsp expression in EC, respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	conflicting	conflicting	ADJ	JJ	Degree=Pos	_	_	_	_
3	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	due	due	ADP	IN	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Hsp	Hsp	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1772
# text = MATERIAL AND METHODS:
1	MATERIAL	material	NOUN	NN	Number=Sing	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1773
# text = In the present study, we analyzed the effects of CyA, aspirin, and indomethacin on T cell proliferation using a proliferation assay.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CyA	Cya	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	indomethacin	indomethacin	ADV	RB	_	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
24	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1774
# text = To explore the expression of adhesion molecules, monocyte chemoattractant protein-1 (MCP-1), and Hsp60 in human umbilical vein endothelial cells (HUVECs), Northern blot analyses were used.
1	To	to	PART	TO	_	_	_	_	_
2	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
24	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
32	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
33	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1775
# text = To examine the activation status of the transcription factors nuclear factor kappaB (NF-kappaB) and heat shock factor-1 (HSF-1), electrophoretic mobility shift assays were performed.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	status	status	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
20	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	HSF	Hsf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
30	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
31	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
32	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1776
# text = RESULTS: With the exception of indomethacin, the used immunosuppressive and anti-inflammatory agents significantly inhibited T cell proliferation in response to influenza virus antigen in a dose-dependent manner.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	With	with	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	used	use	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	influenza	influenza	ADJ	JJ	Degree=Pos	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	antigen	antigen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1777
# text = Interestingly, CyA and indomethacin did not suppress tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression on HUVECs, whereas aspirin had an inhibitory effect.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	indomethacin	indomethacin	ADV	RB	_	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	HUVECs	Huvecs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
28	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1778
# text = These observations correlated with the modulation of NF-kappaB activity in EC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1779
# text = All agents tested induced expression of Hsp60 6 hr after application.
1	All	all	DET	DT	_	_	_	_	_
2	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	application	application	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1780
# text = In addition, aspirin and indomethacin, but not CyA, induced Hsp70 expression in HUVECs that correlated with induction of HSF-1 activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	indomethacin	indomethacin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	Hsp70	Hsp70	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	HSF	HSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1781
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1782
# text = Our results show that the tested agents (except indomethacin) are inhibitors of the T cell-mediated immune response, as expected, that aspirin is an effective suppressor of adhesion molecule expression, and that all three agents can induce Hsp60 in HUVECs.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	except	except	ADP	IN	_	_	_	_	_
10	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
31	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	all	all	DET	DT	_	_	_	_	_
40	three	three	NUM	CD	NumType=Card	_	_	_	_
41	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
42	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
43	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
44	Hsp60	Hsp60	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1783
# text = These data provide the molecular basis for the notion that (1) part of the anti-atherogenic effect of aspirin may be due to the prevention of the adhesion of sensitized T cells to stressed EC; (2) that part of the atherosclerosis-promoting effect of CyA may be due to its potential as an inducer of Hsp60 expression and its inability to down-regulate adhesion molecule expression on EC; and (3) that down-regulation of MCP-1 expression by aspirin may result in decreased recruitment of monocytes into the arterial intima beneath stressed EC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	part	part	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	anti-atherogenic	anti-atherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	sensitized	sensitize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	stressed	stress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	part	part	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
48	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	_
51	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
52	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
53	due	due	ADP	IN	_	_	_	_	_
54	to	to	ADP	IN	_	_	_	_	_
55	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
56	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
57	as	as	ADP	IN	_	_	_	_	_
58	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
65	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
66	to	to	ADP	IN	_	_	_	_	_
67	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
70	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
71	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
72	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
73	on	on	ADP	IN	_	_	_	_	_
74	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	;	;	PUNCT	,	_	_	_	_	_
76	and	and	CCONJ	CC	_	_	_	_	_
77	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
78	3	3	X	LS	_	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	_
80	that	that	SCONJ	IN	_	_	_	_	_
81	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
82	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
83	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
84	of	of	ADP	IN	_	_	_	_	_
85	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
86	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
87	1	1	NUM	CD	NumType=Card	_	_	_	_
88	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
89	by	by	ADP	IN	_	_	_	_	_
90	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
91	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
92	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
93	in	in	ADP	IN	_	_	_	_	_
94	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
95	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
96	of	of	ADP	IN	_	_	_	_	_
97	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
98	into	into	ADP	IN	_	_	_	_	_
99	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
100	arterial	arterial	ADJ	JJ	Degree=Pos	_	_	_	_
101	intima	intima	NOUN	NN	Number=Sing	_	_	_	_
102	beneath	beneath	ADP	IN	_	_	_	_	_
103	stressed	stress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
104	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
105	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1784
# text = Document 00300176 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300176	00300176	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1785
# text = Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	chaperone	chaperone	NOUN	NN	Number=Sing	_	_	_	_
7	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
16	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	PAS	Pas	NOUN	NN	Number=Sing	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1786
# text = The intracellular dioxin receptor mediates signal transduction by dioxin and functions as a ligand-activated transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	dioxin	dioxin	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	dioxin	dioxin	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1787
# text = It contains a basic helix-loop-helix (bHLH) motif contiguous with a Per-Arnt-Sim (PAS) homology region.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	contiguous	contiguous	ADJ	JJ	Degree=Pos	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	Per-	per-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Sim	Sim	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PAS	PAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1788
# text = In extracts from nonstimulated cells the receptor is recovered in an inducible cytoplasmic form associated with the 90-kDa heat shock protein (hsp90), a molecular chaperone.
1	In	in	ADP	IN	_	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	nonstimulated	nonstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	recovered	recover	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	form	form	NOUN	NN	Number=Sing	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
21	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
22	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
30	chaperone	chaperone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1789
# text = We have reconstituted ligand-dependent activation of the receptor to a DNA-binding form by using the dioxin receptor and its bHLH-PAS partner factor
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	dioxin	dioxin	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	PAS	Pas	NOUN	NN	Number=Sing	_	_	_	_
27	partner	partner	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1790
# text = Arnt expressed by in vitro translation in reticulocyte lysate.
1	Arnt	Arnt	NOUN	NN	Number=Sing	_	_	_	_
2	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
6	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	reticulocyte	reticulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
9	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1791
# text = Deletion of the PAS domain of the receptor resulted in constitutive dimerization with Arnt.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PAS	PAS	PROPN	NNP	Number=Sing	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
12	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1792
# text = In contrast, this receptor mutant showed low levels of xenobiotic response element-binding activity, indicating that the PAS domain may be important for DNA-binding affinity and/or specificity of the receptor.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	xenobiotic	xenobiotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	PAS	Pas	NOUN	NN	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	or	or	CCONJ	CC	_	_	_	_	_
34	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1793
# text = It was not possible to reconstitute dioxin receptor function with proteins expressed in wheat germ lysate.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
7	dioxin	dioxin	ADP	IN	_	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	wheat	wheat	NOUN	NN	Number=Sing	_	_	_	_
15	germ	germ	NOUN	NN	Number=Sing	_	_	_	_
16	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1794
# text = In line with these observations, reticulocyte lysate but not wheat germ lysate promoted the association of de novo synthesized dioxin receptor with hsp90.
1	In	in	ADP	IN	_	_	_	_	_
2	line	line	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	reticulocyte	reticulocyte	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
8	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	wheat	wheat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	germ	germ	NOUN	NN	Number=Sing	_	_	_	_
13	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
14	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	de	de	PROPN	NNP	Number=Sing	_	_	_	_
19	novo	novo	ADV	RB	_	_	_	_	_
20	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1795
# text = At least two distinct domains of the receptor mediated interaction with hsp90: the ligand-binding domain located within the PAS region and, surprisingly, the bHLH domain.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
19	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	PAS	Pas	PROPN	NNP	Number=Sing	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	bHLH	bhlh	ADJ	JJ	Degree=Pos	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1796
# text = Whereas ligand-binding activity correlated with association with hsp90, bHLH-hsp90 interaction appeared to be important for DNA-binding activity but not for dimerization of the receptor.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	association	association	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	_
15	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
16	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1797
# text = Several distinct roles for hsp90 in modulating dioxin receptor function are therefore likely: correct folding of the ligand-binding domain, interference with Arnt heterodimerization, and folding of a DNA-binding conformation of the bHLH domain.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	therefore	therefore	ADV	RB	_	_	_	_	_
13	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	correct	correct	ADJ	JJ	Degree=Pos	_	_	_	_
16	folding	folding	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	_
27	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	folding	folding	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
36	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	bHLH	bHLH	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
40	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1798
# text = Thus, the dioxin receptor system provides a complex and interesting model of the regulation of transcription factors by hsp90.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	system	system	NOUN	NN	Number=Sing	_	_	_	_
7	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
12	model	model	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1799
# text = Document 00300177 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300177	00300177	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1800
# text = Danazol decreases transcription of estrogen receptor gene in human monocytes.
1	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
2	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1801
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1802
# text = Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	danazol	danazol	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	over	over	ADV	RB	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	month	month	NOUN	NN	Number=Sing	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
19	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	approximately	approximately	VERB	VB	VerbForm=Inf	_	_	_	_
23	50	50	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	respectively	respectively	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1803
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1804
# text = Danazol did not alter the degradation rate of ER mRNA in monocytes.
1	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
2	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	ER	er	NOUN	NN	Number=Sing	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1805
# text = 3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
4	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	ER	er	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	on	on	ADP	IN	_	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1806
# text = 4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
6	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
7	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	ER	er	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	ER	er	NOUN	NN	Number=Sing	_	_	_	_
24	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	ER	er	NOUN	NN	Number=Sing	_	_	_	_
27	expressions	expression	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1807
# text = Document 00300178 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300178	00300178	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1808
# text = An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	intricate	intricate	ADJ	JJ	Degree=Pos	_	_	_	_
3	arrangement	arrangement	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	SCONJ	IN	_	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1809
# text = alpha 4 integrins mediate cell-cell and cell-extracellular matrix interactions that are critical for maturation and function of the immune system as well as differentiation of skeletal muscle.
1	alpha	alpha	ADV	RB	_	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	_
4	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	well	well	ADV	RB	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	skeletal	skeletal	ADJ	JJ	Degree=Pos	_	_	_	_
31	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1810
# text = Here we examine molecular mechanisms controlling the pattern of alpha 4 expression.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	examine	examine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	alpha	alpha	ADV	RB	_	_	_	_	_
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1811
# text = The activity of constructs containing 5' deletion mutants of the alpha 4 gene promoter was compared in transfection assays into cell lines that express alpha 4 and cell lines that do not.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
20	assays	assays	ADV	RB	_	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	alpha	alpha	ADV	RB	_	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	do	do	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1812
# text = The sequence between position -42 and -76 base pairs (bp) was required for efficient transcription in cells that express alpha 4, but it showed no activity in HeLa cells, which do not express alpha 4.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	position	position	NOUN	NN	Number=Sing	_	_	_	_
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	42	42	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	76	76	NUM	CD	NumType=Card	_	_	_	_
10	base	base	NOUN	NN	Number=Sing	_	_	_	_
11	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	alpha	alpha	ADV	RB	_	_	_	_	_
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
40	alpha	alpha	ADP	IN	_	_	_	_	_
41	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1813
# text = Three binding sites for the Ets family of transcription factors are found in this region: two adjacent sites at positions -50 and -54 bp and a more 5' site at position -67 bp.
1	Three	three	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	50	50	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	54	54	NUM	CD	NumType=Card	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
31	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	'	'	PUNCT	``	_	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	position	position	NOUN	NN	Number=Sing	_	_	_	_
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	67	67	NUM	CD	NumType=Card	_	_	_	_
38	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1814
# text = Using a series of constructs containing deletions and mutations in this region, we found that the 3'-most site alone was sufficient for binding GA-binding protein alpha (GABP alpha)/GABP beta and for a low level of transcriptional activation.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	series	series	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	alone	alone	ADV	RB	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	GA	ga	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GABP	Gabp	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
39	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
44	level	level	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1815
# text = When all three sites were present, a second complex "a" was detected, which contains an unknown member of the Ets family.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	three	three	NUM	CD	NumType=Card	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
12	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	"	"	PUNCT	''	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Int	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
21	member	member	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Ets	et	PROPN	NNPS	Number=Plur	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1816
# text = Formation of complex a was cell-type specific and correlated with a high level of transcription.
1	Formation	Formation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1817
# text = Deletion of the 5'-most Ets site had no effect on binding to GABP alpha/GABP beta, but it eliminated a.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
8	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
20	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	eliminated	eliminate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1818
# text = Concomitant with this loss of a, a new Ets-1-containing complex "c" appeared.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
10	Ets	Ets	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	"	"	PUNCT	''	_	_	_	_	_
19	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1819
# text = Complex c substituted efficiently for complex a in transcriptional activation.
1	Complex	complex	NOUN	NN	Number=Sing	_	_	_	_
2	c	care	NOUN	NN	Number=Sing	_	_	_	_
3	substituted	substitute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	efficiently	efficiently	ADV	RB	_	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	complex	complex	NUM	CD	NumType=Card	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1820
# text = We conclude that although neither of the two 5'-most Ets sites alone binds nuclear protein, they appear to act as modulators which control the pattern of Ets proteins that bind the alpha 4 gene promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	neither	neither	DET	DT	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
13	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	alone	alone	ADV	RB	_	_	_	_	_
16	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	modulators	modulator	NOUN	NNS	Number=Plur	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	4	4	NUM	CD	NumType=Card	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1821
# text = This arrangement of Ets sites, coupled with the tissue- and developmental-specific expression of Ets members, likely play a key role in defining the pattern of alpha 4 integrin.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	arrangement	arrangement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	likely	likely	ADV	RB	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	SCONJ	IN	_	_	_	_	_
27	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	alpha	alpha	ADV	RB	_	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1822
# text = Document 00300179 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300179	00300179	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1823
# text = Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.
1	Kappa	Kappa	PROPN	NNP	Number=Sing	_	_	_	_
2	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	differentially	differentially	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
16	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1824
# text = Kappa B
1	Kappa	Kappa	PROPN	NNP	Number=Sing	_	_	_	_
2	B	B	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1825
# text = (kappa
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1826
# text = B) enhancer binding proteins isolated from the nuclei of activated human T cells produce two distinct nucleoprotein complexes when incubated with the kappa B element from the interleukin-2 receptor-alpha (IL-2R alpha) gene.
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
18	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
19	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1827
# text = These two DNA-protein complexes are composed of at least four host proteins (p50, p55, p75, p85), each of which shares structural similarity with the v-rel oncogene product.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	at	at	ADV	RB	_	_	_	_	_
11	least	least	ADV	RBS	Degree=Sup	_	_	_	_
12	four	four	NUM	CD	NumType=Card	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p55	p55	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	p75	p75	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p85	p85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	each	each	DET	DT	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Int	_	_	_	_
28	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
29	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
30	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
35	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
36	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1828
# text = Nuclear expression of these proteins is induced with distinctly biphasic kinetics following phorbol ester activation of T cells (p55/p75 early and p50/p85 late).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	distinctly	distinctly	ADV	RB	_	_	_	_	_
10	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
11	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
14	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	p55	p55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p75	p75	NOUN	NN	Number=Sing	_	_	_	_
23	early	early	ADV	RB	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	p50/	p50/	SYM	SYM	_	_	_	_	SpaceAfter=No
26	p85	p85	NUM	CD	NumType=Card	_	_	_	_
27	late	late	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1829
# text = DNA-protein crosslinking studies have revealed that the more rapidly migrating B2 complex contains both p50 and p55 while the more slowly migrating B1 complex is composed of p50, p55, p75, and p85.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	crosslinking	crosslink	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	more	more	ADV	RBR	_	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
12	B2	b2	NUM	CD	NumType=Card	_	_	_	_
13	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
14	contains	contain	NOUN	NNS	Number=Plur	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p55	p55	NOUN	NN	Number=Sing	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	more	more	ADV	RBR	_	_	_	_	_
22	slowly	slowly	ADV	RB	_	_	_	_	_
23	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
24	B1	b1	NUM	CD	NumType=Card	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	p55	p55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	p75	p75	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	p85	p85	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1830
# text = Site-directed mutagenesis of the wild-type IL-2R alpha kappa B enhancer (GGGGAATCTCCC) has revealed that the binding of p50 and p55 (B2 complex) is particularly sensitive to alteration of the 5' triplet of deoxyguanosine residues.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	GGGGAATCTCCC	GGGGAATCTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p55	p55	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	B2	b2	NUM	CD	NumType=Card	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	particularly	particularly	ADV	RB	_	_	_	_	_
35	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	``	_	_	_	_	_
42	triplet	triplet	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	deoxyguanosine	deoxyguanosine	NOUN	NN	Number=Sing	_	_	_	_
45	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1831
# text = In contrast, formation of the B1 complex, reflecting the binding of p75 and p85, critically depends upon the more 3' sequences of this enhancer element.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	reflecting	reflecte	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p75	p75	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p85	p85	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	critically	critically	ADV	RB	_	_	_	_	_
19	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	upon	upon	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	'	'	PUNCT	``	_	_	_	_	_
25	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1832
# text = DNA binding by all four of these Rel-related factors is blocked by selective chemical modification of lysine and arginine residues, suggesting that both of these basic amino acids are required for binding to the kappa B element.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	_
5	four	four	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	Rel-related	Rel-relate	ADJ	JJ	Degree=Pos	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
14	chemical	chemical	ADJ	JJ	Degree=Pos	_	_	_	_
15	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lysine	lysine	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
28	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
29	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	SCONJ	IN	_	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1833
# text = Similarly, covalent modification of free sulfhydryl groups with diamide (reversible) or N-ethylmaleimide (irreversible) results in a complete loss of DNA binding activity.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	covalent	covalent	ADJ	JJ	Degree=Pos	_	_	_	_
4	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	sulfhydryl	sulfhydryl	NOUN	NN	Number=Sing	_	_	_	_
8	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	N	not	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	ethylmaleimide	ethylmaleimide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	results	result	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1834
# text = In contrast, mild oxidation with glucose oxidase selectively inhibits p75 and p85 binding while not blocking p50 and p55 interactions.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
5	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	_
8	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	p75	p75	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p85	p85	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	p55	p55	NUM	CD	NumType=Card	_	_	_	_
21	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1835
# text = These findings suggest that reduced cysteine thiols play an important role in the DNA binding activity of this family of Rel-related transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
7	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
8	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Rel-	Rel-	X	GW	_	_	_	_	SpaceAfter=No
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1836
# text = Document 00300180 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300180	00300180	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1837
# text = Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1838
# text = Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	C	c	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	recently	recently	ADV	RB	_	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
45	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	1	1	X	LS	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	by	by	ADP	IN	_	_	_	_	_
53	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
55	4	4	NUM	CD	NumType=Card	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	on	on	ADP	IN	_	_	_	_	_
62	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1839
# text = We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	PTK	Ptk	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
7	herbimycin	herbimycin	ADP	IN	_	_	_	_	_
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
11	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1840
# text = Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	PTK	PTK	NUM	CD	NumType=Card	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1841
# text = This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
4	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	pathophysiological	pathophysiological	ADJ	JJ	Degree=Pos	_	_	_	_
7	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	e.g.	e.g.	X	FW	_	_	_	_	_

# sent_id = 1842
# text = inflammation and atherosclerosis).
1	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1843
# text = Document 00300181 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300181	00300181	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1844
# text = Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
1	Glycation	Glycation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
7	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HIT	Hit	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1845
# text = Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a decrease in the insulin content of the cells.
1	Prolonged	Prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	poor	poor	ADJ	JJ	Degree=Pos	_	_	_	_
3	glycemic	glycemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	control	control	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	non-insulin	non-insulin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
10	mellitus	mellitus	CCONJ	CC	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	often	often	ADV	RB	_	_	_	_	_
13	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
32	content	content	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1846
# text = As a step toward elucidating the pathophysiological background of the so-called glucose toxicity to pancreatic beta cells, we induced glycation in HIT-T15 cells using a sugar with strong deoxidizing activity, D-ribose, and examined the effects on insulin gene transcription.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	step	step	NOUN	NN	Number=Sing	_	_	_	_
4	toward	toward	SCONJ	IN	_	_	_	_	_
5	elucidating	elucidat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	pathophysiological	pathophysiological	ADJ	JJ	Degree=Pos	_	_	_	_
8	background	background	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	glucose	glucose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HIT	Hit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	sugar	sugar	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
35	deoxidizing	deoxidizing	NOUN	NN	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	D-	d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	ribose	ribose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1847
# text = The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	more	more	ADV	RBR	_	_	_	_	_
15	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	actin	actin	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	approximately	approximately	ADV	RB	_	_	_	_	_
28	50	50	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	when	when	ADV	WRB	PronType=Int	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	kept	keep	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	3	3	NUM	CD	NumType=Card	_	_	_	_
47	d	would	PROPN	NNP	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	40	40	NUM	CD	NumType=Card	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	60	60	NUM	CD	NumType=Card	_	_	_	_
55	mM	mm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1848
# text = D-ribose, respectively.
1	D-	D-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	ribose	ribose	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1849
# text = In agreement with this, decrease in the insulin mRNA and insulin content was observed in the glycation-induced cells.
1	In	in	ADP	IN	_	_	_	_	_
2	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
13	content	content	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1850
# text = Also, gel mobility shift analyses using specific antiserum revealed decrease in the DNA-binding activity of an insulin gene transcription factor, PDX-1/IPF1/STF-1.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	PDX	PDX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1/IPF1/STF	-1/IPF1/STF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1851
# text = These effects of D-ribose seemed almost irreversible but could be prevented by addition of 1 mM aminoguanidine or 10 mM N-acetylcysteine, thus suggesting that glycation and reactive oxygen species, generated through the glycation reaction, serve as mediators of the phenomena.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	D-	d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	ribose	ribose	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
6	seemed	seem	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	almost	almost	ADV	RB	_	_	_	_	_
8	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	mM	mm	NOUN	NN	Number=Sing	_	_	_	_
18	aminoguanidine	aminoguanidine	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	mM	mm	NOUN	NN	Number=Sing	_	_	_	_
22	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
31	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
32	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
38	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	as	as	SCONJ	IN	_	_	_	_	_
42	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1852
# text = These observations suggest that protein glycation in pancreatic beta cells, which occurs in vivo under chronic hyperglycemia, suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	DET	WDT	PronType=Int	_	_	_	_
13	occurs	occurs	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
18	hyperglycemia	hyperglycemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
21	insulin	insulin	ADP	IN	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
28	part	part	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	_
34	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1853
# text = Document 00300182 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300182	00300182	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1854
# text = Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB.
1	Lactobacilli	Lactobacilli	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
4	host	host	NOUN	NN	Number=Sing	_	_	_	_
5	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1855
# text = Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T lymphocyte and THP-1 macrophage cell lines.
1	Lactobacilli	Lactobacilli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	component	component	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
9	flora	flora	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1856
# text = Activation of the LTR in Jurkat cells was strongly enhanced by vanadate and inhibited by catalase, implicating H2O2.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1857
# text = In contrast, activation in THP-1 cells occurred in the absence of vanadate and was unaffected by catalase.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1858
# text = The active material partitioned into the phenol layer on hot aqueous phenol extraction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	material	material	NOUN	NN	Number=Sing	_	_	_	_
4	partitioned	partition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	_
8	layer	layer	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	hot	hot	ADJ	JJ	Degree=Pos	_	_	_	_
11	aqueous	aqueous	ADJ	JJ	Degree=Pos	_	_	_	_
12	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	_
13	extraction	extraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1859
# text = Lactobacilli also increased tumor necrosis factor-alphaand interleukin-1betaproduction and activated NF-kappaB in THP-1 cells and increased tumor necrosis factor-alphaproduction by human monocytes.
1	Lactobacilli	Lactobacilli	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alphaand	alphaand	NOUN	NN	Number=Sing	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	betaproduction	betaproduction	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-alphaproduction	-alphaproduction	NOUN	NN	Number=Sing	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1860
# text = Human vaginal fluid specimens had comparable properties, which correlated with their bacterial content.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
3	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
4	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
7	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	content	content	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1861
# text = These findings suggest the presence in vaginal fluid of agent(s) derived from indigenous bacteria that can activate the HIV-1 LTR, cytokine production, and NF-kappaB in cells of macrophage lineage, with possible influence on vaginal physiology and host defense.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
8	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	agent	agent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	s	s	X	AFX	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	indigenous	indigenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
38	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	with	with	SCONJ	IN	_	_	_	_	_
41	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
42	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
43	on	on	ADP	IN	_	_	_	_	_
44	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
45	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	host	host	NOUN	NN	Number=Sing	_	_	_	_
48	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1862
# text = Document 00300183 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300183	00300183	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1863
# text = Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
26	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1864
# text = Tax corresponds to a 40-kDa transforming protein from the pathogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) that activates nuclear expression of the NF-kappaB/Rel family of transcription factors by an unknown mechanism.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
13	retrovirus	retrovirus	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
37	family	family	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
44	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1865
# text = Tax expression promotes N-terminal phosphorylation and degradation of IkappaB alpha, a principal cytoplasmic inhibitor of NF-kappaB.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	promotes	promote	NOUN	NNS	Number=Plur	_	_	_	_
4	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1866
# text = Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in response to tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) stimulation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
16	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	normally	normally	ADV	RB	_	_	_	_	_
27	phosphorylate	phosphorylate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	IkappaB	Ikappab	ADJ	JJ	Degree=Pos	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	serines	serine	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
42	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	_
59	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1867
# text = In contrast, a mutant of Tax termed M22, which does not induce NF-kappaB, fails to activate either IKKalpha or IKKbeta.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
8	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	M22	m22	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	either	either	CCONJ	CC	_	_	_	_	_
23	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1868
# text = Furthermore, endogenous IKK enzymatic activity was significantly elevated in HTLV-1-infected and Tax-expressing T-cell lines.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
5	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1869
# text = Transfection of kinase-deficient mutants of IKKalpha and IKKbeta into either human Jurkat T or 293 cells also inhibits NF-kappaB-dependent reporter gene expression induced by Tax.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	either	either	DET	DT	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	293	293	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1870
# text = Similarly, a kinase-deficient mutant of NIK (NF-kappaB-inducing kinase), which represents an upstream kinase in the TNF-alpha and IL-1 signaling pathways leading to IKKalpha and IKKbeta activation, blocks Tax induction of NF-kappaB.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inducing	induce	ADJ	JJ	Degree=Pos	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
34	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
35	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
43	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1871
# text = However, plasma membrane-proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF2 and TRAF6 adaptors, which effectively block signaling through the cytoplasmic tails of the TNF-alpha and IL-1 receptors, respectively, do not inhibit Tax induction of NF-kappaB.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
4	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	apparently	apparently	ADV	RB	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
17	since	since	SCONJ	IN	_	_	_	_	_
18	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	TRAF2	TRAF2	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
26	adaptors	adaptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	effectively	effectively	ADV	RB	_	_	_	_	_
30	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
31	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
35	tails	tail	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	do	do	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
50	not	not	PART	RB	_	_	_	_	_
51	inhibit	inhibit	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
52	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
53	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1872
# text = Together, these studies demonstrate that HTLV-1 Tax exploits a distal part of the proinflammatory cytokine signaling cascade leading to induction of NF-kappaB.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
11	exploits	exploit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
14	part	part	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
20	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
21	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1873
# text = The pathological alteration of this cytokine pathway leading to NF-kappaB activation by Tax may play a central role in HTLV-1-mediated transformation of human T cells, clinically manifested as the adult T-cell leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
3	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	clinically	clinically	ADV	RB	_	_	_	_	_
34	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
38	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1874
# text = Document 00300184 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300184	00300184	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1875
# text = Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
14	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
15	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1876
# text = Although case-oriented evidence for an association of Epstein-Barr virus (EBV) with gastric carcinoma has been accumulating recently, the interaction(s) between EBV and gastric epithelial cells is/are largely unknown.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	case	case	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	oriented	oriented	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	association	association	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
19	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	accumulating	accumulate	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
23	recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	s	s	X	AFX	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
34	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	largely	largely	ADV	RB	_	_	_	_	_
40	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1877
# text = In this study, we examined seven EBV-positive gastric carcinoma tissues for viral gene expression at the mRNA level, from which studies on the EBV oncogenicity in human epithelial cells will benefit.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	seven	seven	NUM	CD	NumType=Card	_	_	_	_
8	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
12	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
13	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
29	oncogenicity	oncogenicity	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
35	benefit	benefit	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1878
# text = Reverse transcription-PCR analysis showed that all seven EBV-positive tumour tissues constitutively expressed EBV nuclear antigen (EBNA) 1 mRNA, but not EBNA2 mRNA.
1	Reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	seven	seven	ADJ	JJ	Degree=Pos	_	_	_	_
10	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
14	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
15	constitutively	constitutively	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	_
29	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1879
# text = The EBNA transcription was initiated from one of three EBNA promoters, Qp: by contrast, both Cp and Wp were silent, thus resulting in the lack of EBNA2 mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Qp	Qp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	_
32	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1880
# text = Latent membrane protein (LMP) 2A mRNA was detected in three of seven cases; however, neither LMP1 nor LMP2B mRNA was detected in any of the tumours tested.
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	A	a	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	three	three	NUM	CD	NumType=Card	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	seven	seven	NUM	CD	NumType=Card	_	_	_	_
16	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	neither	neither	CCONJ	CC	_	_	_	_	_
21	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
22	nor	nor	CCONJ	CC	_	_	_	_	_
23	LMP2	LMP2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	any	any	DET	DT	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	_
33	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1881
# text = Transcripts from the BamHI-A region of the viral genome were detectable in all cases.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
11	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1882
# text = BZLF1 mRNA and the product, an immediate-early gene for EBV replication, was not expressed in any of them, thereby suggesting that the tumour cells carried EBV genomes in a tightly latent form.
1	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	any	any	DET	DT	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	thereby	thereby	ADV	RB	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
32	genomes	genome	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	tightly	tightly	ADV	RB	_	_	_	_	_
36	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
37	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1883
# text = These findings further extended our previous data regarding EBV latency in gastric carcinoma cells at the protein level, and have affirmed that the programme of viral gene expression in the tumour more closely resembles 'latency I' represented by Burkitt's lymphoma than 'latency II' represented by the majority of nasopharyngeal carcinomas.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	extended	extend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	data	data	NOUN	NN	Number=Sing	_	_	_	_
8	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
10	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
13	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	affirmed	affirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	programme	programme	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
33	more	more	ADV	RBR	_	_	_	_	_
34	closely	closely	ADV	RB	_	_	_	_	_
35	resembles	resemble	NOUN	NNS	Number=Plur	_	_	_	_
36	'	's	PART	POS	_	_	_	_	SpaceAfter=No
37	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
39	'	'	PUNCT	``	_	_	_	_	_
40	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	's	's	PART	POS	_	_	_	_	_
44	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
47	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
48	II	Ii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	'	'	PUNCT	''	_	_	_	_	_
50	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
56	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1884
# text = Document 00300185 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300185	00300185	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1885
# text = Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1886
# text = The immunomodulatory cytokine IL-4 affects cells of most hemopoietic lineages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	affects	affects	NOUN	NNS	Number=Plur	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
11	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1887
# text = IL-4 is secreted by activated Th2 but not Th1 cells and plays a major role in the immune response by modulating the differentiation of naive Th cells toward the Th2 phenotype.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
28	Th	th	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	toward	toward	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	Th2	th2	NUM	CD	NumType=Card	_	_	_	_
33	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1888
# text = We have previously identified an enhancer element, PRE-I, that is essential for the function of the human IL-4 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1889
# text = To investigate the mechanisms responsible for tissue-specific expression of the IL-4 gene, we analyzed nuclear factors binding to the PRE-I site and compared the binding activities of these factors to the IL-4 promoter of Th1 and Th2 cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	site	site	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	4	4	NUM	CD	NumType=Card	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1890
# text = We show that PRE-I interacts with PMA- and PMA/ionomycin-inducible, cyclosporin A-sensitive nuclear factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	PMA/ionomycin	PMA/ionomycin	ADP	IN	_	_	_	_	SpaceAfter=No
13	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
16	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1891
# text = Using anti-C/EBPbeta (NF-IL6), anti-C/EBPdelta (NF-IL6beta), anti-NF-ATc, anti-NF-ATp, anti-Fos, and anti-Jun
1	Using	Using	PROPN	NNP	Number=Sing	_	_	_	_
2	anti-C/EBPbeta	anti-C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	anti-C/EBPdelta	anti-C/EBPdelta	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	anti-NF	anti-NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	anti-NF	anti-NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	anti-Fos	anti-Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	anti-Jun	anti-Jun	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1892
# text = Abs we demonstrate that the previously identified PRE-I binding factor POS-1 is composed of different transcription factors in different Th cell subsets.
1	Abs	Ab	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	previously	previously	ADV	RB	_	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	Th	th	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1893
# text = In the IL-4-producing
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	producing	producing	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1894
# text = Th0-like human Jurkat and mouse EL-4 cells, POS-1 (designated POS-1a) contains NF-IL6beta and Jun.
1	Th0	Th0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	like	like	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
8	EL	EL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1895
# text = In the mouse Th2 D10 cells and in the human Th2 clones, POS-1 (designated POS-1b) contains NF-IL6beta, Jun, and NF-ATc/p.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
5	D10	D10	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	ATc/	ATcith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
36	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1896
# text = In contrast, POS-1 was not found in nuclear extracts of human Th1 clones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
16	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1897
# text = These findings suggest that PRE-I may play a role in the differential regulation of IL-4 gene expression levels.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1898
# text = Document 00300186 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300186	00300186	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1899
# text = Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1900
# text = To examine the role of protein phosphatases in T cell activation, Jurkat cells were treated with okadaic acid, an inhibitor of type 1 and 2A phosphatases, and nuclear extracts were examined for the presence of AP1 as a measure of early T cell activation.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Jurkat	Jurkat	SCONJ	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	type	type	NOUN	NN	Number=Sing	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	A	a	NOUN	NN	Number=Sing	_	_	_	_
29	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	measure	measure	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1901
# text = Okadaic acid was found to be a potent inducer of AP1.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	AP1	AP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1902
# text = In contrast to phorbol esters such as phorbol myristate acetate (PMA), the induction of AP1 by okadaic acid occurs predominantly by transcriptional activation of the jun and fos family of proto-oncogenes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
5	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
6	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
9	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
10	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
22	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
23	predominantly	predominantly	ADV	RB	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1903
# text = Surprisingly, while the addition of phytohemagglutinin further enhanced the induction of AP1, the addition of PMA inhibited it.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
8	further	further	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
19	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1904
# text = Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto-oncogenes including c-jun, junD, and junB and to a lesser extent the fos family including c-fos and fra-1.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	dramatically	dramatically	ADV	RB	_	_	_	_	_
8	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
9	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
10	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	junD	jund	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
30	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
35	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	fra	fra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1905
# text = By comparison, PMA is a very inefficient inducer of the jun gene family in Jurkat cells.
1	By	by	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	inefficient	inefficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1906
# text = Similar to its effect on the induction of AP1 by okadaic acid, PMA inhibits the induction of c-jun mRNA by okadaic acid.
1	Similar	similar	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	PART	POS	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
16	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
25	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1907
# text = Transfection of c-jun promoter constructs confirmed the marked difference between PMA and okadaic acid in inducing c-jun transcription.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1908
# text = The induction of AP1 by okadaic acid suggests that protein phosphatases 1 and 2A (PP1 and PP2A) may be involved in T cell activation as important negative regulators of the transcription factor AP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	A	a	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PP1	PP1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PP2	PP2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1909
# text = Document 00300187 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300187	00300187	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1910
# text = Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anoxia	anoxia	ADP	IN	_	_	_	_	SpaceAfter=No
5	/reoxygenation-induced	/reoxygenation-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
7	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1911
# text = The objectives of this study were to (1) determine the time course of neutrophil adhesion to monolayers of human umbilical vein endothelial cells (HUVECs) that were exposed to 60 minutes of anoxia followed by 30 to 600 minutes of reoxygenation and (2) define the mechanisms responsible for both the early (minutes) and late (hours) hyperadhesivity of postanoxic HUVECs to human neutrophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	objectives	objective	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	_
14	course	course	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
23	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	60	60	NUM	CD	NumType=Card	_	_	_	_
34	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	anoxia	anoxia	NOUN	NN	Number=Sing	_	_	_	_
37	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	30	30	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	600	600	NUM	CD	NumType=Card	_	_	_	_
42	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	2	2	X	LS	_	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
52	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
53	for	for	ADP	IN	_	_	_	_	_
54	both	both	CCONJ	CC	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
62	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
63	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	hyperadhesivity	hyperadhesivity	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	postanoxic	postanoxic	ADJ	JJ	Degree=Pos	_	_	_	_
68	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
69	to	to	ADP	IN	_	_	_	_	_
70	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
71	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1912
# text = The results clearly demonstrate that anoxia/reoxygenation (A/R) leads to a biphasic increase in neutrophil adhesion to HUVECs, with peak responses occurring at 30 minutes (phase 1) and 240 minutes (phase 2) after reoxygenation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	clearly	clearly	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	anoxia/	anoxia/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	A/	A/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
10	R	r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
25	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
26	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	30	30	NUM	CD	NumType=Card	_	_	_	_
29	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	240	240	NUM	CD	NumType=Card	_	_	_	_
36	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	after	after	ADP	IN	_	_	_	_	_
42	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1913
# text = Oxypurinol and catalase inhibited phase-1 adhesion, suggesting a role for xanthine oxidase and H2O2.
1	Oxypurinol	Oxypurinol	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	catalase	catalase	VERB	VB	VerbForm=Inf	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	xanthine	xanthine	NOUN	NN	Number=Sing	_	_	_	_
15	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1914
# text = In comparison, platelet activating factor (PAF) contributed to both phases of neutrophil adhesion.
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	platelet	platelet	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	contributed	contribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1915
# text = Anti-intercellular adhesion molecule-1 (ICAM-1) and anti-P-selectin antibodies (monoclonal antibodies [mAbs]) attenuated phase-1 neutrophil adhesion, consistent with roles for constitutively expressed ICAM-1 and enhanced surface expression of preformed P-selectin.
1	Anti-intercellular	Anti-intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	anti-P-	anti-P-	X	GW	_	_	_	_	SpaceAfter=No
13	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
17	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
18	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	constitutively	constitutively	ADV	RB	_	_	_	_	_
34	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	preformed	preform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1916
# text = Phase-2 neutrophil adhesion was attenuated by an anti-E-selectin mAb, indicating a dominant role of this adhesion molecule in the late phase response.
1	Phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	anti-E-	anti-E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
12	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
25	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1917
# text = Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides containing the nuclear factor-kappa B or activator protein-1 cognate DNA sequences significantly attenuated phase-2 response, suggesting a role for de novo macromolecule synthesis.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	_
4	D	d	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	with	with	SCONJ	IN	_	_	_	_	_
9	competing	compete	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ds	d	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-oligonucleotides	-oligonucleotides	SCONJ	IN	_	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	cognate	cognate	NOUN	NN	Number=Sing	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
27	significantly	significantly	ADV	RB	_	_	_	_	_
28	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	de	de	PROPN	NNP	Number=Sing	_	_	_	_
39	novo	novo	ADV	RB	_	_	_	_	_
40	macromolecule	macromolecule	ADJ	JJ	Degree=Pos	_	_	_	_
41	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1918
# text = Surface expression of ICAM-1, P-selectin, and E-selectin on HUVECs correlated with the phase-1 and -2 neutrophil adhesion responses.
1	Surface	surface	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
16	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1919
# text = Collectively, these findings indicate that A/R elicits a two-phase neutrophil-endothelial cell adhesion response that involves transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
8	/R	/r	NOUN	NN	Number=Sing	_	_	_	_
9	elicits	elicit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
14	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1920
# text = Document 00300188 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300188	00300188	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1921
# text = Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	B7	B7	NUM	CD	NumType=Card	_	_	_	_
14	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
15	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1922
# text = We have earlier shown that stimulation of human CD4+ T cells with SEA presented on Chinese hamster ovary (CHO)-DR transfectants coexpressing either B7 or LFA-3 resulted in distinct cytokine profiles.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	earlier	earlier	ADV	RB	_	_	_	_	_
4	shown	shown	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	SEA	SEa	NOUN	NN	Number=Sing	_	_	_	_
15	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
18	hamster	hamster	NOUN	NN	Number=Sing	_	_	_	_
19	ovary	ovary	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	DR	dr	NOUN	NN	Number=Sing	_	_	_	_
25	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	_
26	coexpressing	coexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
27	either	either	CCONJ	CC	_	_	_	_	_
28	B7	B7	NUM	CD	NumType=Card	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
36	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
37	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1923
# text = We now demonstrate that B7, but not LFA-3, strongly costimulated IL-2 transcription and mRNA expression in CD4+ T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	LFA	LFA	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+	+	SYM	SYM	_	_	_	_	_
25	T	t	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1924
# text = Maximal increase in IL-2 transcription was recorded with CHO-DR/B7/LFA-3, suggesting a cooperative effect of B7 and LFA-3 at the transcriptional level.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	recorded	record	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DR/B7/LFA	DR/B7/LFA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	B7	B7	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	LFA	LFA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1925
# text = Gel-shift analysis demonstrated that stimulation of CD4+ T cells with CHO-DR and staphylococcal enterotoxin
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
19	enterotoxin	enterotoxin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1926
# text = A was sufficient to induce significant amounts of NF-kappa B binding proteins, whereas induction of AP-1 binding proteins required costimulation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1927
# text = LFA-3 induced moderate levels of AP-1, but did not influence the levels of NF-kappa B, while B7 costimulation strongly induced both AP-1 and substantially enhanced NF-kappa B binding proteins.
1	LFA	Lfa	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	B7	B7	NUM	CD	NumType=Card	_	_	_	_
26	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
27	strongly	strongly	ADV	RB	_	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	substantially	substantially	ADV	RB	_	_	_	_	_
35	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1928
# text = The CHO-DR/B7/LFA-3 triple transfectant induced a further increase in AP-1 and NF-kappa B binding proteins compared with the double transfectants.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DR/B7/LFA	DR/B7/LFA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	triple	triple	NOUN	NN	Number=Sing	_	_	_	_
8	transfectant	transfectant	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
28	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1929
# text = The level of Oct-1 binding proteins remained similar in all samples.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	all	all	DET	DT	_	_	_	_	_
13	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1930
# text = Super-shift analysis revealed that the NF-kappa B complex of costimulated CD4+ T cells contained large amounts of p50, substantial amounts of p65, and marginal levels of c-Rel proteins.
1	Super	super	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	shift	shift	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	T	t	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	contained	containe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
21	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
26	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	marginal	marginal	ADJ	JJ	Degree=Pos	_	_	_	_
32	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1931
# text = The AP-1 binding proteins contained c-Jun, Jun-D, and Fra-1, but marginal amounts of Jun-B and c-Fos.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-D	-D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	marginal	marginal	ADJ	JJ	Degree=Pos	_	_	_	_
21	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	B	B	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1932
# text = Our results indicate distinct effects of B7 and LFA-3 costimulation on the activity of AP-1 and NF-kappa B.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	B7	B7	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1933
# text = These may partly account for the differential effects of B7 and LFA-3 costimulation on IL-2 expression.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	partly	partly	ADV	RB	_	_	_	_	_
4	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	B7	B7	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1934
# text = Document 00300189 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300189	00300189	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1935
# text = Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.
1	Blockade	Blockade	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	dithiocarbamates	dithiocarbamate	NOUN	NNS	Number=Plur	_	_	_	_
8	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
9	novel	novel	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1936
# text = Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types.
1	Dithiocarbamates	Dithiocarbamates	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	DTCs	Dtcs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	recently	recently	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	number	number	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1937
# text = Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
23	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
28	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
29	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1938
# text = We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DTCs	Dtcs	PROPN	NNP	Number=Sing	_	_	_	_
6	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1939
# text = This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
14	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
23	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	only	only	ADV	RB	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	but	but	CCONJ	CC	_	_	_	_	_
47	also	also	ADV	RB	_	_	_	_	_
48	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1940
# text = Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1.
1	Accordingly	accordingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	pyrrolidine	pyrrolidine	PROPN	NNP	Number=Sing	_	_	_	_
13	DTC	DTC	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	either	either	DET	DT	_	_	_	_	_
34	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
35	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
36	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
37	plus	plus	CCONJ	CC	_	_	_	_	_
38	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
41	against	against	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	CD3-T	Cd3-t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
47	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
50	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1941
# text = Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
4	differentially	differentially	ADV	RB	_	_	_	_	_
5	targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1942
# text = Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells.
1	Strikingly	strikingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
4	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	immunocytochemical	immunocytochemical	ADJ	JJ	Degree=Pos	_	_	_	_
7	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
8	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
11	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	shuttling	shuttling	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	accelerated	accelerated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	export	export	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1943
# text = We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	PDTC	Pdtc	PROPN	NNP	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	shuttling	shuttling	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	transiently	transiently	ADV	RB	_	_	_	_	_
25	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	during	during	ADP	IN	_	_	_	_	_
36	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
43	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
44	NH2	Nh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
52	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
53	by	by	SCONJ	IN	_	_	_	_	_
54	directly	directly	ADV	RB	_	_	_	_	_
55	phosphorylating	phosphorylat	VERB	VBG	VerbForm=Ger	_	_	_	_
56	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1944
# text = In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
14	support	support	NOUN	NN	Number=Sing	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
17	use	use	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	DTCs	DTC	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1945
# text = Document 00300190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300190	00300190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1946
# text = Activation of human macrophages by mechanical ventilation in vitro.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
7	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1947
# text = Positive-pressure mechanical ventilation supports gas exchange in patients with respiratory failure but is also responsible for significant lung injury.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	_
4	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
5	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
6	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gas	gas	NOUN	NN	Number=Sing	_	_	_	_
8	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
20	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
21	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1948
# text = In this study, we have developed an in vitro model in which isolated lung cells can be submitted to a prolonged cyclic pressure-stretching strain resembling that of conventional mechanical ventilation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	submitted	submit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	_
24	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stretching	stretching	VERB	VBG	VerbForm=Ger	_	_	_	_
27	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
28	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
32	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
33	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1949
# text = In this model, cells cultured on a Silastic membrane were elongated up to 7% of their initial diameter, corresponding to a 12% increase in cell surface.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Silastic	Silastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	elongated	elongate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	up	up	ADP	RP	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
20	diameter	diameter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1950
# text = The lung macrophage was identified as the main cellular source for critical inflammatory mediators such as tumor necrosis factor-alpha, the chemokines interleukin (IL)-8 and -6, and matrix metalloproteinase-9 in this model system of mechanical ventilation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	source	source	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
25	interleukin	interleukin	ADV	RB	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	8	8	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	matrix	matrix	NUM	CD	NumType=Card	_	_	_	_
37	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	9	9	NUM	CD	NumType=Card	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	model	model	NOUN	NN	Number=Sing	_	_	_	_
43	system	system	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
46	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1951
# text = These mediators were measured in supernatants from ventilated alveolar macrophages, monocyte-derived macrophages, and promonocytic THP-1 cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	ventilated	ventilate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1952
# text = Nuclear factor-kappaB was found to be activated in ventilated macrophages.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	ventilated	ventilate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1953
# text = Synergistic proinflammatory effects of mechanical stress and molecules such as bacterial endotoxin were observed, suggesting that mechanical ventilation might be particularly deleterious in preinjured or infected lungs.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
6	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
19	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
20	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	particularly	particularly	ADV	RB	_	_	_	_	_
23	deleterious	deleterious	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	preinjured	preinjure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1954
# text = Dexamethasone prevented IL-8 and tumor necrosis factor-alpha secretion in ventilated macrophages.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	8	8	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	ventilated	ventilate	ADJ	JJ	Degree=Pos	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1955
# text = Mechanical ventilation induced low levels of IL-8 secretion by alveolar type II-like cells.
1	Mechanical	Mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
2	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1956
# text = Other lung cell types such as endothelial cells, bronchial cells, and fibroblasts failed to produce IL-8 in response to a prolonged cyclic pressure-stretching load.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	_
27	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	stretching	stretching	VERB	VBG	VerbForm=Ger	_	_	_	_
30	load	load	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1957
# text = This model is of particular value for exploring physical stress-induced signaling pathways, as well as for testing the effects of novel ventilatory strategies or adjunctive substances aimed at modulating cell activation induced by mechanical ventilation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	model	model	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
6	value	value	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	exploring	explore	VERB	VBG	VerbForm=Ger	_	_	_	_
9	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
10	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	for	for	SCONJ	IN	_	_	_	_	_
19	testing	test	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
24	ventilatory	ventilatory	NOUN	NN	Number=Sing	_	_	_	_
25	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	adjunctive	adjunctive	ADJ	JJ	Degree=Pos	_	_	_	_
28	substances	substance	NOUN	NNS	Number=Plur	_	_	_	_
29	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	at	at	SCONJ	IN	_	_	_	_	_
31	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
37	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1958
# text = Document 00300191 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300191	00300191	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1959
# text = Temporal control of IgH gene expression in developing B cells by the 3' locus control region.
1	Temporal	Temporal	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IgH	Igh	DET	DT	_	_	_	_	_
5	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1960
# text = The suggested roles of the downstream 3' regions acting as a Locus Control Region (LCR), have allowed comparisons to be made between the regulation of the IgH locus with other model systems whose gene expression is governed by LCR activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	''	_	_	_	_	_
9	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
10	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Locus	Locus	PROPN	NNP	Number=Sing	_	_	_	_
14	Control	Control	PROPN	NNP	Number=Sing	_	_	_	_
15	Region	region	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	comparisons	comparison	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
32	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	model	model	NOUN	NN	Number=Sing	_	_	_	_
36	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
37	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
38	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	governed	govern	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	LCR	Lcr	ADJ	JJR	Degree=Cmp	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1961
# text = Here we summarize the importance of the IgH 3'LCR and its putative functional role in IgH gene expression and compare it with the 5'LCR regulatory region of the human beta-globin locus.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	summarize	summarize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	_
9	3'	3's	PART	POS	_	_	_	_	SpaceAfter=No
10	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	IgH	Igh	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	compare	compare	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	5'	5'	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	LCR	Lcr	ADP	IN	_	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	region	region	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
35	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1962
# text = Document 00300192 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300192	00300192	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1963
# text = Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL3	IL3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	NOUN	NN	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1964
# text = Role of AP-1- and octamer-binding proteins in control of IL3 gene expression.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1965
# text = We have investigated the molecular and biochemical basis for activation of interleukin 3 (IL3) gene expression in primary human T lymphocytes following CD3 and CD2 receptor stimulation or activation by phytohemagglutinin plus phorbol 12-myristate 13-acetate.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
25	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
34	plus	plus	CCONJ	CC	_	_	_	_	_
35	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
36	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
39	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1966
# text = Using transfection and reporter gene assays specifically designed for primary T lymphocytes in conjunction with gel retardation assays, Western blot analyses and UV cross-linking studies, we found that c-Jun, c-Fos, and octamer-binding proteins play a major role in transcriptional activation of the IL3 gene via their interaction with two specific regions contained within the IL3 5'-flanking sequence.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	designed	design	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
17	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
18	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
21	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
22	analyses	analyse	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
25	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
27	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
42	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
43	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
46	role	role	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	_
53	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
54	via	via	ADP	IN	_	_	_	_	_
55	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
56	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
57	with	with	ADP	IN	_	_	_	_	_
58	two	two	NUM	CD	NumType=Card	_	_	_	_
59	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
60	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
61	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	within	within	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	_
65	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
67	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
68	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
69	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1967
# text = Additionally, the region between bases -107 and -59 of the IL3 promoter containing putative AP-2 and Sp1 binding motifs appears necessary for basal level expression of the IL3 gene.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	107	107	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	59	59	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1968
# text = The data also indicate that CD2 receptor activation and phytohemagglutinin plus phorbol 12-myristate 13-acetate stimulation augment T cell IL3 gene expression through the same cis- and trans-activating signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	CD2	Cd2	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
11	plus	plus	CCONJ	CC	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
29	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1969
# text = These results should contribute to a better understanding of the regulation of IL3 gene expression in human T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
4	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
8	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1970
# text = Document 00300193 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300193	00300193	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1971
# text = Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.
1	Tcf	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	glycogen	glycogen	ADJ	JJ	Degree=Pos	_	_	_	_
15	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1972
# text = Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade.
1	Beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
7	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
11	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
12	polarity	polarity	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
14	Armadillo	Armadillo	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Wnt	Wnt	PROPN	NNP	Number=Sing	_	_	_	_
29	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
30	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1973
# text = Recently, members of the Lef/Tcf transcription factor family have been identified as protein partners of beta-catenin, explaining how beta-catenin alters gene expression.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	members	member	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Lef	Lef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	partners	partner	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	explaining	explain	VERB	VBG	VerbForm=Ger	_	_	_	_
24	how	how	ADV	WRB	PronType=Int	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
28	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
29	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1974
# text = Here we report that in T cells, Tcf-1 also becomes transcriptionally active through interaction with beta-catenin, suggesting that the Wnt signal transduction pathway is operational in T lymphocytes as well.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Wnt	Wnt	ADJ	JJ	Degree=Pos	_	_	_	_
27	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	operational	operational	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1975
# text = However, although Wnt signals are known to inhibit the activity of the negative regulatory protein kinase glycogen synthase kinase-3beta (GSK-3beta), resulting in increased levels of beta-catenin, we find no evidence for involvement of GSK-3beta in Tcf-mediated transcription in T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	Wnt	Wnt	ADJ	JJ	Degree=Pos	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	glycogen	glycogen	NOUN	NN	Number=Sing	_	_	_	_
19	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GSK	Gsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	beta-	beta-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	no	no	DET	DT	_	_	_	_	_
42	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	GSK	GSK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	T	t	PROPN	NNP	Number=Sing	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1976
# text = That is, a dominant negative GSK-3beta does not specifically activate
1	That	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	GSK	Gsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 1977
# text = Tcf transcription and stimuli (lithium or phytohemagglutinin) that inhibit GSK-3beta activity also do not activate
1	Tcf	Tcf	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	lithium	lithium	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	GSK	GSK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 1978
# text = Tcf reporter genes.
1	Tcf	Tcf	ADJ	JJ	Degree=Pos	_	_	_	_
2	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1979
# text = Thus, inhibition of GSK-3beta is insufficient to activate Tcf-dependent transcription in T lymphocytes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GSK	GSK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	Tcf	Tcf	ADV	RB	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1980
# text = In contrast, in C57MG fibroblast cells, lithium inactivates GSK-3beta and induces Tcf-controlled transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	C57MG	C57MG	ADJ	JJ	Degree=Pos	_	_	_	_
6	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	lithium	lithium	NOUN	NN	Number=Sing	_	_	_	_
10	inactivates	inactivate	NOUN	NNS	Number=Plur	_	_	_	_
11	GSK	GSK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
17	Tcf-	Tcf-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1981
# text = This is the first demonstration that lithium can alter gene expression of Tcf-responsive genes, and points to a difference in regulation of Wnt signaling between fibroblasts and lymphocytes.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	lithium	lithium	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	alter	alter	ADV	RB	_	_	_	_	_
10	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	points	point	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Wnt	Wnt	ADJ	JJ	Degree=Pos	_	_	_	_
27	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1982
# text = Document 00300194 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300194	00300194	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1983
# text = Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
11	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	OTF2	Otf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1984
# text = The tissue-specific expression of the MOPC 141 immunoglobulin heavy-chain gene was studied by using in vitro transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	MOPC	Mopc	PROPN	NNPS	Number=Plur	_	_	_	_
9	141	141	NUM	CD	NumType=Card	_	_	_	_
10	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
11	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1985
# text = B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3', located in the upstream region of this promoter and in the promoters of all other immunoglobulin heavy- and light-chain genes.
1	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	ATGCAAAG	ATGCAAAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	all	all	DET	DT	_	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
39	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
45	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1986
# text = The interaction of purified octamer transcription factors 1 and 2 (OTF1 and OTF2) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OTF1	Otf1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	OTF2	Otf2	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	MOPC	Mopc	NOUN	NN	Number=Sing	_	_	_	_
19	141	141	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1987
# text = Purified OTF1 from HeLa cells and OTF1 and OTF2 from B cells bound to identical sequences within the heavy-chain promoter.
1	Purified	Purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	OTF1	OTF1	PROPN	NNP	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	OTF1	OTF1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	OTF2	OTF2	NUM	CD	NumType=Card	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1988
# text = The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3', and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	OTF	OTF	ADJ	JJ	Degree=Pos	_	_	_	_
3	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	extended	extend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	over	over	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	heptamer	heptamer	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
13	CTCAGGA	CTCAGGa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	heptamer	heptamer	NOUN	NN	Number=Sing	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1989
# text = In addition to these elements, we identified a second regulatory element, the N element with the sequence 5'-GGAACCTCCCCC-3'.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N	N	PROPN	NNP	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
22	-GGAACCTCCCCC	-ggaacctccccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1990
# text = The N element could independently mediate low levels of transcription in both B-cell and HeLa-cell extracts, and, in conjunction with the octamer element, it can promote high levels of transcription in B-cell extracts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	N	n	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	independently	independently	ADV	RB	_	_	_	_	_
6	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HeLa	HeLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
32	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
33	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1991
# text = The N element bound a transcription factor, NTF, that is ubiquitous in cell-type distribution, and NTF was distinct from any of the previously described proteins that bind to similar sequences.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	N	N	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	bound	bound	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NTF	NTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NTF	NTF	PROPN	NNP	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	any	any	DET	DT	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	previously	previously	ADV	RB	_	_	_	_	_
29	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1992
# text = Based on these results, we propose that NTF and OTF2 interactions (both with their cognate DNA elements and possibly at the protein-protein level) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	NTF	NTF	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	OTF2	OTF2	NUM	CD	NumType=Card	_	_	_	_
12	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	both	both	CCONJ	CC	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	possibly	possibly	ADV	RB	_	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
40	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
41	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
43	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
44	for	for	SCONJ	IN	_	_	_	_	_
45	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
46	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1993
# text = Document 00300195 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300195	00300195	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1994
# text = Fibroblast growth factor-1 (FGF-1) enhances IL-2 production and nuclear translocation of NF-kappaB in FGF receptor-bearing Jurkat T cells.
1	Fibroblast	Fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	FGF	FGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	T	T	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1995
# text = Fibroblast growth factors (FGFs) are heparin-binding proteins crucial to embryogenesis, angiogenesis, and wound healing.
1	Fibroblast	Fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	FGFs	FGF	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	heparin	heparin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	embryogenesis	embryogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	angiogenesis	angiogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	wound	wound	ADJ	JJ	Degree=Pos	_	_	_	_
20	healing	healing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1996
# text = FGF-1 is abundantly expressed in the synovium in rheumatoid arthritis and in rejecting allografts, sites of chronic immune-mediated inflammation.
1	FGF	Fgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	abundantly	abundantly	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	synovium	synovium	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	rejecting	reject	VERB	VBG	VerbForm=Ger	_	_	_	_
16	allografts	allograft	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
21	immune-mediated	immune-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
22	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1997
# text = The frequency of FGF-1-responsive T cells is increased in the peripheral blood of these disorders, and a high percentage of infiltrating T cells in rheumatoid arthritis synovium express receptors for FGF-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
24	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	SCONJ	IN	_	_	_	_	_
26	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
31	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
32	synovium	synovium	NOUN	NN	Number=Sing	_	_	_	_
33	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
34	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1998
# text = To understand the action of FGF-1 in T cells, studies were initiated in Jurkat T cells that express the signaling isoform of FGF receptor-1.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1999
# text = These experiments show that FGF-1 stimulation of Jurkat T cells provides a second signal that augments TCR-mediated IL-2 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	augments	augment	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	TCR	Tcr	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2000
# text = Analogous to costimulation via CD28, this activity is mediated through activation of Rel/kappaB, a family of transcription factors known to regulate IL-2 and other activation-inducible proteins.
1	Analogous	Analogous	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
4	via	via	ADP	IN	_	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2001
# text = FGF-1 alone induces modest nuclear translocation of kappaB-binding proteins, and this translocation is enhanced by the combination of anti-CD3 and FGF-1.
1	FGF	Fgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	modest	modest	ADJ	JJ	Degree=Pos	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	FGF	FGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2002
# text = This NF-kappaB binding complex is composed of transcriptionally active p65(RelA)/p50 heterodimers and results primarily from the targeted degradation of IkappaB-alpha, an inhibitor that sequesters Rel/kappaB in the cytoplasm.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	p50	p50	NUM	CD	NumType=Card	_	_	_	_
18	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	primarily	primarily	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	sequesters	sequester	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2003
# text = These data are the first to show a connection between FGF-1 signaling and NF-kappaB activation outside of embryonic development.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	connection	connection	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	outside	outside	ADP	IN	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
23	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2004
# text = The signaling events that link FGF receptor-1 engagement and NF-kappaB activation in Jurkat are probably distinct from the CD28 costimulation pathway, since FGF-1-induced Rel/kappaB binding proteins do not contain significant levels of c-Rel and are not identical with the CD28 response complex.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	link	link	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	FGF	Fgf	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	probably	probably	ADV	RB	_	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
24	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	since	since	ADP	IN	_	_	_	_	_
28	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	Rel/	Rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
37	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
40	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
53	response	response	NOUN	NN	Number=Sing	_	_	_	_
54	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2005
# text = Document 00300196 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300196	00300196	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2006
# text = Activation of NF-kappa B by interleukin 2 in human blood monocytes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2007
# text = We report here that interleukin 2 (IL-2) acts on human blood monocytes by enhancing binding activity of the transcription factor NF-kappa B to its consensus sequence in the 5' regulatory enhancer region of the IL-2 receptor alpha chain (p55).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
32	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	'	's	PUNCT	``	_	_	_	_	_
37	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
47	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	p55	p55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2008
# text = Similarly, IL-2 activates NF-kappa B in the human monocytic cell line U 937, but not in resting human T-cells.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	_
17	U	U	PROPN	NNP	Number=Sing	_	_	_	_
18	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2009
# text = This effect is detectable within 15 min and peaks 1 h after exposure to IL-2.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	15	15	NUM	CD	NumType=Card	_	_	_	_
7	min	min	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2010
# text = Enhanced NF-kappa B binding activity is followed by functional activation in that inducibility of the IL-2 receptor alpha chain is mediated by enhanced NF-kappa B binding and that a heterologous promoter containing the NF-kappa B consensus sequence (-291 to -245) of the IL-2 receptor alpha chain gene is activated.
1	Enhanced	enhance	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	that	that	PRON	WDT	PronType=Dem	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
45	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
46	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
47	291	291	NUM	CD	NumType=Card	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	245	245	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	2	2	NUM	CD	NumType=Card	_	_	_	_
57	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
58	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
59	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
60	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
61	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
62	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2011
# text = In addition, IL-2 is capable of increasing transcript levels of the p50 gene coding for the p50 subunit of the NF-kappa B transcription factor, whereas mRNA levels of the p65 NF-kappa B gene remained unchanged.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
11	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
21	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
37	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
42	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	unchanged	unchang	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2012
# text = Document 00300197 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300197	00300197	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2013
# text = A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2014
# text = Analysis of the chromatin organization of the integrated human immunodeficiency virus type 1 (HIV-1) genome has previously revealed a major constitutive DNase I-hypersensitive site associated with the pol gene (E. Verdin, J. Virol.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
5	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	integrated	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	previously	previously	ADV	RB	_	_	_	_	_
22	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
38	Verdin	Verdin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
41	Virol	Virol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2015
# text = 65:6790-6799, 1991).
1	65:6790-6799	65:6790-6799	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2016
# text = In the present report, high-resolution mapping of this site with DNase I and micrococcal nuclease identified a nucleosome-free region centered around nucleotides (nt) 4490 to 4766.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
9	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	micrococcal	micrococcal	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	_
19	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	nucleosome	nucleosome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	around	around	ADP	IN	_	_	_	_	_
27	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	nt	not	PART	RB	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	4490	4490	NUM	CD	NumType=Card	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	4766	4766	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2017
# text = A 500-bp fragment encompassing this hypersensitive site (nt 4481 to 4982) exhibited transcription-enhancing activity (two- to threefold) when it was cloned in its natural position with respect to the HIV-1 promoter after transient transfection in U937 and CEM cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	500	500	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
6	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	nt	not	PART	RB	_	_	_	_	_
12	4481	4481	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	4982	4982	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	enhancing	enhancing	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	when	when	ADV	WRB	PronType=Int	_	_	_	_
28	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
34	position	position	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	after	after	ADP	IN	_	_	_	_	_
44	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
45	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	U937	U937	NUM	CD	NumType=Card	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	CEM	cem	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2018
# text = Using in vitro footprinting and gel shift assays, we have identified four distinct binding sites for nuclear proteins within this positive regulatory element.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	four	four	NUM	CD	NumType=Card	_	_	_	_
14	distinct	distinct	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2019
# text = Site B (nt 4519 to 4545) specifically bound four distinct nuclear protein complexes: a ubiquitous factor, a T-cell-specific factor, a B-cell-specific factor, and the monocyte/macrophage- and B-cell-specific transcription factor PU.1/Spi-1.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
2	B	b	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	nt	not	PART	RB	_	_	_	_	_
5	4519	4519	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	4545	4545	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	specifically	specifically	ADV	RB	_	_	_	_	_
10	bound	bound	ADP	IN	_	_	_	_	_
11	four	four	NUM	CD	NumType=Card	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	PU.1/	PU.1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
48	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2020
# text = In most HIV-1 isolates in which this PU box was not conserved, it was replaced by a binding site for the related factor Ets1.
1	In	in	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	PU	Pu	NOUN	NN	Number=Sing	_	_	_	_
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	Ets1	ets1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2021
# text = Factors binding to site C (nt 4681 to 4701) had a DNA-binding specificity similar to that of factors binding to site B, except for PU.1/Spi-1.
1	Factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	nt	not	PART	RB	_	_	_	_	_
8	4681	4681	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	4701	4701	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	except	except	ADP	IN	_	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	PU.1/	Pu.1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	Spi-1	spi-1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2022
# text = A GC box containing a binding site for Sp1 was identified (nt 4623 to 4631).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
3	box	box	NOUN	NN	Number=Sing	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	nt	not	PART	RB	_	_	_	_	_
14	4623	4623	NUM	CD	NumType=Card	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	4631	4631	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2023
# text = Site D (nt 4816 to 4851) specifically bound a ubiquitously expressed factor.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
2	D	d	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	nt	not	PART	RB	_	_	_	_	_
5	4816	4816	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	4851	4851	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	specifically	specifically	ADV	RB	_	_	_	_	_
10	bound	bound	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
13	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2024
# text = These results identify a transcriptional regulatory element associated with a nuclease-hypersensitive site in the pol gene of HIV-1 and suggest that its activity may be controlled by a complex interplay of cis-regulatory elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
34	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cis-regulatory	cis-regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2025
# text = Document 00300198 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300198	00300198	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2026
# text = Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2027
# text = Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J. Biol.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	b	PROPN	NNP	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	ML	Ml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-1a	-1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	line	line	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	Singh	Singh	PROPN	NNP	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	Aggarwal	Aggarwal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
53	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2028
# text = Chem. 1995: 270: 10631).
1	Chem.	Chem.	PROPN	NNP	Number=Sing	_	_	_	_
2	1995	1995	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	270	270	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	10631	10631	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2029
# text = Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
33	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
38	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
47	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
48	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
58	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	1	1	NUM	CD	NumType=Card	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
66	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
67	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
68	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	ELAM	ELAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
72	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
73	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2030
# text = Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
1	Like	like	ADP	IN	_	_	_	_	_
2	ML	Ml	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-1a	-1a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	dermal	dermal	ADJ	JJ	Degree=Pos	_	_	_	_
7	microvessel	microvessel	NOUN	NN	Number=Sing	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	MVEC	MVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	treated	treat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	rapidly	rapidly	ADV	RB	_	_	_	_	_
17	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	within	within	ADP	IN	_	_	_	_	_
20	30	30	NUM	CD	NumType=Card	_	_	_	_
21	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	completely	completely	ADV	RB	_	_	_	_	_
32	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	co-treatment	co-treatment	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	phenylarsine	phenylarsine	NOUN	NN	Number=Sing	_	_	_	_
37	oxide	oxide	ADV	RB	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	PAO	pao	INTJ	UH	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
44	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2031
# text = The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ELAM	ELAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	MVEC	MVEC	PROPN	NNP	Number=Sing	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	completely	completely	ADV	RB	_	_	_	_	_
27	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2032
# text = PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
1	PAO	pao	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	action	action	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2033
# text = Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
1	Besides	besides	ADP	IN	_	_	_	_	_
2	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	all	all	DET	PDT	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	_
30	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2034
# text = Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	attachment	attachment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	MVEC	MVEC	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2035
# text = Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	directly	directly	ADV	RB	_	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	indirectly	indirectly	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2036
# text = Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.
1	Because	because	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
14	target	target	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
17	development	development	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	atherogenesis	atherogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
27	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2037
# text = Document 00300199 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300199	00300199	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2038
# text = Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
12	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2039
# text = Co-stimulation of T-lymphocytes by T-cell receptor (TcR) occupancy and activation of the CD28 surface molecule results in enhanced proliferation and interleukin 2 (IL-2) production.
1	Co-stimulation	Co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2040
# text = The increase in IL-2 gene expression triggered by CD28 involves a kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2041
# text = B-like sequence in the 5'-regulatory region of the IL-2 promoter, called CD28-responsive element.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2042
# text = Stimulation of T-cells by agonistic anti-CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate (PMA)- or TcR-derived signals induces the enhanced activation of the transcription factor NF-kappa B.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	agonistic	agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
7	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	TcR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2043
# text = Here we report that CD28 engagement, however, exerts opposite effects on the transcription factor AP-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
6	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2044
# text = Whereas anti-CD28 together with PMA increased the DNA binding and trans-activation activity of NF-kappa B, PMA-induced activation of AP-1 was significantly suppressed.
1	Whereas	whereas	ADV	RB	_	_	_	_	_
2	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
3	together	together	ADV	RB	_	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	significantly	significantly	ADV	RB	_	_	_	_	_
31	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2045
# text = The inhibitory effect exerted by anti-CD28 was observed at the level of DNA binding as well as in functional reporter-gene assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	anti-CD28	anti-cd28	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2046
# text = These results suggest that the two transcription factors are independently regulated and may perform different functions during T-cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	independently	independently	ADV	RB	_	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	perform	perform	VERB	VB	VerbForm=Inf	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2047
# text = Document 003001100 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001100	003001100	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2048
# text = Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
1	Integrin-	Integrin-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	message	message	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2049
# text = A possible signaling role for the Syk tyrosine kinase.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
8	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2050
# text = Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	aspect	aspect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2051
# text = In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
27	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
32	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	two	two	NUM	CD	NumType=Card	_	_	_	_
36	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	about	about	ADP	IN	_	_	_	_	_
41	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	75	75	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	125	125	NUM	CD	NumType=Card	_	_	_	_
48	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2052
# text = In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
6	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	nuclear	nuclear	VERB	VB	VerbForm=Inf	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
15	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_
49	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
52	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
57	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2053
# text = The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
5	genistein	genistein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	herbimycin	herbimycin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	block	block	NOUN	NN	Number=Sing	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	integrin-	integrin-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	message	message	NOUN	NN	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	causal	causal	ADJ	JJ	Degree=Pos	_	_	_	_
28	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
29	between	between	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2054
# text = The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	components	component	NOUN	NNS	Number=Plur	_	_	_	_
3	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	paxillin	paxillin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	pp125FAK	pp125fak	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2055
# text = In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	tyrosine	tyrosine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	FAK	Fak	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	paxillin	paxillin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2056
# text = In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	adhering	adhere	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	pre-treatment	pre-treatment	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	cytochalasin	cytochalasin	NOUN	NN	Number=Sing	_	_	_	_
8	D	d	NOUN	NN	Number=Sing	_	_	_	_
9	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	FAK	Fak	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	paxillin	paxillin	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	while	while	SCONJ	IN	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	message	message	NOUN	NN	Number=Sing	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2057
# text = These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	component	component	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
37	messages	message	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2058
# text = Document 003001101 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001101	003001101	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2059
# text = Sterol dependent LDL-receptor gene transcription in lymphocytes from normal and CML patients.
1	Sterol	Sterol	PROPN	NNP	Number=Sing	_	_	_	_
2	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	LDL	Ldl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CML	cml	ADJ	JJ	Degree=Pos	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2060
# text = Sterol regulatory element (SRE) has been recognized to regulate various key genes coding for especially low density lipoprotein (LDL)-receptor, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and HMG-CoA synthase known to play a crucial role in the cholesterol feedback mechanism.
1	Sterol	Sterol	PROPN	NNP	Number=Sing	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	especially	especially	ADV	RB	_	_	_	_	_
18	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
19	density	density	NOUN	NN	Number=Sing	_	_	_	_
20	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	3-	3-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	hydroxy	hydroxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	methylglutaryl	methylglutaryl	NOUN	NN	Number=Sing	_	_	_	_
33	coenzyme	coenzyme	NOUN	NN	Number=Sing	_	_	_	_
34	A	A	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	CoA	CoA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	reductase	reductase	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CoA	CoA	PROPN	NNP	Number=Sing	_	_	_	_
45	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
46	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	to	to	PART	TO	_	_	_	_	_
48	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
51	role	role	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	_
55	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
56	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2061
# text = The deranged cholesterol feedback mechanism has been widely recognised in initiation as well as progression of various types of cancers including chronic myeloid leukaemia (CML).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	deranged	derange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	_
4	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	widely	widely	ADV	RB	_	_	_	_	_
9	recognised	recognise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
23	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
24	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CML	CML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2062
# text = Consequently, the present study was addressed to understand this phenomenon and revealed the existence of a unique 47 kDa protein factor having affinity for this SRE sequence in lymphocytes from normal subjects as well as its absence in lymphocytes from untreated CML patients.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	addressed	address	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
19	47	47	NUM	CD	NumType=Card	_	_	_	_
20	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	SRE	Sre	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	well	well	ADV	RB	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
43	CML	cml	NOUN	NN	Number=Sing	_	_	_	_
44	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2063
# text = However, this factor appeared when the CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CML	CML	PROPN	NNP	Number=Sing	_	_	_	_
9	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
10	achieved	achieve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	haematological	haematological	ADJ	JJ	Degree=Pos	_	_	_	_
13	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CHR	CHR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
21	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2064
# text = Further, an inverse relationship was also observed between sterol modulated LDL-receptor gene transcription and the binding affinity of this 47 kDa factor to the SRE sequence.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inverse	inverse	ADJ	JJ	Degree=Pos	_	_	_	_
5	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	_
11	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LDL	LDL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	47	47	NUM	CD	NumType=Card	_	_	_	_
24	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	SRE	Sre	PROPN	NNP	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2065
# text = Based upon these results we propose that alpha-interferon through its receptor initiates phosphatidic acid dependent signalling which in turn regulates the affinity of 47 kDa sterol regulatory element binding factor as well as LDL-receptor gene transcription in lymphocytes from CML patients.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upon	upon	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	phosphatidic	phosphatidic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
22	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	47	47	NUM	CD	NumType=Card	_	_	_	_
27	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
28	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	_
29	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	as	as	ADV	RB	_	_	_	_	_
34	well	well	ADV	RB	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	from	from	ADP	IN	_	_	_	_	_
44	CML	CML	PROPN	NNP	Number=Sing	_	_	_	_
45	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2066
# text = Document 003001102 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001102	003001102	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2067
# text = Towards a molecular understanding of T-cell differentiation.
1	Towards	towards	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2068
# text = Lymphoid differentiation is one of the best studied examples of mammalian development.
1	Lymphoid	Lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
8	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	examples	example	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2069
# text = Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	Hans	Hans	PROPN	NNPS	Number=Plur	_	_	_	_
3	Clevers	Clevers	PROPN	NNPS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Michael	Michael	PROPN	NNP	Number=Sing	_	_	_	_
6	Owen	Owen	PROPN	NNP	Number=Sing	_	_	_	_
7	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
8	how	how	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2070
# text = Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	functioning	function	VERB	VBG	VerbForm=Ger	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
21	master	master	NOUN	NN	Number=Sing	_	_	_	_
22	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2071
# text = Document 003001103 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001103	003001103	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2072
# text = Identification of an ionomycin/cyclosporin A-responsive element within the human T cell receptor gamma enhancer.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2073
# text = Activation through the Ca2+/calcineurin pathway is essential to the transcription of many cytokine genes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	+/	+/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2074
# text = The conserved cis-acting sequence, GGAAAA, and transcription factors binding to this sequence are involved in the response to increased intracellular Ca2+ concentrations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GGAAAA	GGAAAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2075
# text = Here we report the identification and importance of the same sequence in a non-cytokine gene, the human T cell receptor gamma (TCRG) enhancer.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	non-cytokine	non-cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TCRG	TCRG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2076
# text = Results from site-directed mutations and electrophoretic mobility shift assays strongly suggest that this sequence mediates the ionomycin-induced activation of the TCRG enhancer.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
9	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
10	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
11	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ionomycin-	ionomycin-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	TCRG	TCRG	PROPN	NNP	Number=Sing	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2077
# text = Our studies provide an explanation for a previous observation that TCRG mRNA levels, but not mRNA levels for T cell receptor alpha and -beta, are increased by ionomycin treatment.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
9	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	TCRG	TCRG	VERB	VBG	VerbForm=Ger	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	mRNA	mRNa	ADJ	JJ	Degree=Pos	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	_
32	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2078
# text = Document 003001104 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001104	003001104	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2079
# text = NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2080
# text = NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	number	number	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2081
# text = In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha).
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2082
# text = In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	events	event	NOUN	NNS	Number=Plur	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	ADV	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
33	JCT6	Jct6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	presents	present	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	_
42	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2083
# text = We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2084
# text = Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	positively	positively	ADV	RB	_	_	_	_	_
5	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	influx	influx	NUM	CD	NumType=Card	_	_	_	_
10	while	while	SCONJ	IN	_	_	_	_	_
11	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2085
# text = Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	staurosporin	staurosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	unchanged	unchange	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2086
# text = TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators.
1	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
2	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
6	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2087
# text = Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
4	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2088
# text = Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	none	none	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
36	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2089
# text = Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acidification	acidification	NOUN	NN	Number=Sing	_	_	_	_
8	facilitated	facilitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B/	Bith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
34	without	without	SCONJ	IN	_	_	_	_	_
35	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
42	step	step	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2090
# text = Document 003001105 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001105	003001105	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2091
# text = Abnormal apoptosis and cell cycle progression in humans exposed to methyl tertiary-butyl ether and benzene contaminating water.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
9	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	methyl	methyl	VERB	VB	VerbForm=Inf	_	_	_	_
12	tertiary	tertiary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	butyl	butyl	NOUN	NN	Number=Sing	_	_	_	_
15	ether	ether	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	benzene	benzene	NOUN	NN	Number=Sing	_	_	_	_
18	contaminating	contaminate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	water	water	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2092
# text = 1. In this study we hypothesized that in individuals with certain genetic makeup, MTBE, benzene or their metabolites act as adducts and may induce programmed cell death.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
13	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
14	makeup	makeup	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	MTBE	Mtbe	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	benzene	benzene	PRON	PRP	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	metabolites	metabolite	NOUN	NN	Number=Sing	_	_	_	_
22	act	act	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	adducts	adduct	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2093
# text = 2. Our study involved a group of 60 male and female subjects who were exposed to MTBE and benzene-contaminated water concentrations up to 76 PPB for MTBE and 14 PPB for benzene, for a period of 5 to 8 years.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	male	male	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
13	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
14	who	who	PRON	WP	PronType=Rel	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	MTBE	Mtbe	VERB	VB	VerbForm=Inf	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	benzene	benzene	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	contaminated	contaminate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	water	water	NOUN	NN	Number=Sing	_	_	_	_
24	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
25	up	up	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	76	76	NUM	CD	NumType=Card	_	_	_	_
28	PPB	Ppb	PROPN	NNP	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	MTBE	MTBE	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	14	14	NUM	CD	NumType=Card	_	_	_	_
33	PPB	Ppb	PROPN	NNP	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	benzene	benzene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	period	period	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	5	5	NUM	CD	NumType=Card	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	8	8	NUM	CD	NumType=Card	_	_	_	_
44	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2094
# text = For comparison, we recruited a control group consisting of 32 healthy males and females with similar age distribution and without a history of exposure to MTBE or benzene.
1	For	for	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	recruited	recruit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	group	group	NOUN	NN	Number=Sing	_	_	_	_
9	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	32	32	NUM	CD	NumType=Card	_	_	_	_
12	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
13	males	male	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	females	female	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
18	age	age	NOUN	NN	Number=Sing	_	_	_	_
19	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	without	without	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	history	history	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	MTBE	MTBE	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	benzene	benzene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2095
# text = 3.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2096
# text = Peripheral blood lymphocytes (PBL) of both groups were tested for the percentage of apoptotic cells and cell cycle progression using flow cytometry.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PBL	PBL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
21	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2097
# text = 4. When apoptotic lymphocytes from exposed individuals were compared to apoptotic lymphocytes from the control group, statistically-significant differences between each mean group were detected (26.4 +/- 1.8 and 12.1 +/- 1.3, respectively), indicating an increased rate of apoptosis in 80.5% of exposed individuals (P < 0.0001, Mann-Whitney U-Test).
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	When	when	ADV	WRB	PronType=Int	_	_	_	_
4	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	exposed	exposed	ADJ	JJ	Degree=Pos	_	_	_	_
8	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	statistically	statistically	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	each	each	DET	DT	_	_	_	_	_
25	mean	mean	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	26.4	26.4	NUM	CD	NumType=Card	_	_	_	_
31	+/-	+/-	SYM	SYM	_	_	_	_	_
32	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	12.1	12.1	NUM	CD	NumType=Card	_	_	_	_
35	+/-	+/-	SYM	SYM	_	_	_	_	_
36	1.3	1.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	80.5	80.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	%	%	SYM	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	P	p	NOUN	NN	Number=Sing	_	_	_	_
55	<	<	PUNCT	-LRB-	_	_	_	_	_
56	0.0001	0.0001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	Mann	Mann	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	Whitney	Whitney	PROPN	NNP	Number=Sing	_	_	_	_
61	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	Test	Test	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2098
# text = MTBE and benzene-induced apoptosis is attributed to a discrete block within the cell cycle progression.
1	MTBE	Mtbe	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	benzene	benzene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
12	block	block	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2099
# text = Because cell cycle analysis showed that in PBL from chemically-exposed individuals, between 20-50% of cells were accumulated at the S-G2/M boundaries.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	chemically	chemically	ADV	RB	_	_	_	_	SpaceAfter=No
11	-exposed	-expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	S-	s-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	G2/	G2/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	M	m	NOUN	NN	Number=Sing	_	_	_	_
28	boundaries	boundary	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2100
# text = 5. One of the signaling molecules which mediates programmed cell death is nuclear factor Kappa-B (NF-kappa B).
1	5	5	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	One	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	death	death	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	Kappa	Kappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2101
# text = NF-kappa B was examined as one of the many molecular mechanisms for mediating cell death by MTBE and benzene.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	b	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	death	death	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	MTBE	Mtbe	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	benzene	benzene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2102
# text = Indeed, addition of inhibitors of NF-kappa B activation pyrrolidine dithiocarbamate (PDTC), to the lymphocytes of the chemically-exposed group was capable of inhibiting programmed cell death by 40%.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
13	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	chemically	chemically	ADV	RB	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
29	of	of	SCONJ	IN	_	_	_	_	_
30	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
31	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	death	death	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2103
# text = This reversal of apoptosis almost to the control level by inhibitor of NF-kappa B activation may indicate involvement of this signaling molecule in MTBE and benzene induction of programmed cell death.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	reversal	reversal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	indicate	indicate	VERB	VB	VerbForm=Inf	_	_	_	_
20	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	MTBE	MTBE	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	benzene	benzene	NOUN	NN	Number=Sing	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2104
# text = Document 003001106 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001106	003001106	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2105
# text = Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation:
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	freshly	freshly	ADV	RB	_	_	_	_	_
8	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2106
# text = a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages.
1	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2107
# text = Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	replicates	replicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	more	more	ADV	RBR	_	_	_	_	_
13	efficiently	efficiently	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	differentiated	differentiated	ADJ	JJ	Degree=Pos	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	freshly	freshly	ADV	RB	_	_	_	_	_
22	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2108
# text = We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	partly	partly	ADV	RB	_	_	_	_	_
8	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2109
# text = We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	changed	change	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MDMs	MDM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	alveolar	alveolar	VERB	VB	VerbForm=Inf	_	_	_	_
34	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	AMs	am	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2110
# text = Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers.
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
11	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	favor	favor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
30	RelB	RelB	NOUN	NN	Number=Sing	_	_	_	_
31	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2111
# text = As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels.
1	As	as	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	AMs	AMs	PROPN	NNPS	Number=Plur	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
13	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
14	although	although	SCONJ	IN	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2112
# text = HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs.
1	HIV	haHive	NOUN	NN	Number=Sing	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2113
# text = The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
10	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
11	time	time	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	partially	partially	ADV	RB	_	_	_	_	_
16	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2114
# text = The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	change	change	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2115
# text = Document 003001107 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001107	003001107	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2116
# text = Involvement of Alu sequences in the cell-specific regulation of transcription of the gamma chain of Fc and T cell receptors.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2117
# text = The Fc epsilon RI-gamma chains are expressed in a variety of hematopoietic cells where they play a critical role in signal transduction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
3	epsilon	epsilon	ADP	IN	_	_	_	_	_
4	RI	RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	where	where	ADV	WRB	PronType=Rel	_	_	_	_
17	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
18	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2118
# text = They are part of the high affinity
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	part	part	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2119
# text = IgE receptor in mast cells, basophils, Langerhans cells, and possibly other cells; a component of the low affinity receptor for IgG (Fc gamma RIIIA or CD16) in natural killer cells and macrophages; and part of the T cell antigen receptor in subsets of T cells.
1	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Langerhans	Langerhans	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	possibly	possibly	ADV	RB	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
28	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
29	RIIIA	RIIIA	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
35	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	;	;	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	part	part	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	T	T	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2120
# text = Here we have investigated the transcriptional regulation of the gamma chain gene by analyzing the 2.5-kilobase sequence upstream of the transcription start site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	start	start	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2121
# text = This sequence contains a promoter specific to cells of hematopoietic lineage.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2122
# text = However, the tissue specificity of this promoter is only partial because it is active in all of the hematopoietic cells tested here, regardless of whether they constitutively express Fc epsilon RI- gamma chain transcripts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
5	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
12	because	because	SCONJ	IN	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	all	all	DET	DT	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	regardless	regardless	ADV	RB	_	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	whether	whether	SCONJ	IN	_	_	_	_	_
28	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	constitutively	constitutively	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
31	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
32	epsilon	epsilon	ADP	IN	_	_	_	_	_
33	RI	Ri	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	_
35	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
36	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
37	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2123
# text = We have identified two adjacent cis-acting regulatory elements, both of which are part of an Alu repeat.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	part	part	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
19	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2124
# text = The first (-445/-366) is a positive element active in both basophils and T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	-445/-	-445/-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	366	366	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2125
# text = The second (-365/-264) binds to nuclear factors, which appear to be different in basophils and T cells, and acts as a negative element in basophils and as a positive one in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	-365/-	-365/-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	264	264	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
35	one	one	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2126
# text = Thus, this Alu repeat (90% identical to Alu consensus sequences) has evolved to become both a positive and negative regulator.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
5	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	%	%	SYM	NN	Number=Sing	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	evolved	evolve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2127
# text = Document 003001108 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001108	003001108	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2128
# text = Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras.
1	Fcgamma	Fcgamma	PROPN	NNP	Number=Sing	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2129
# text = Receptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cellular responses that are very important in host defense, including phagocytosis, cell cytotoxicity, production and secretion of inflammatory mediators, and modulation of the immune response.
1	Receptors	Receptor	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Fc	Fc	ADJ	JJ	Degree=Pos	_	_	_	_
5	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FcR	FcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	_
17	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	very	very	ADV	RB	_	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	host	host	NOUN	NN	Number=Sing	_	_	_	_
30	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
33	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	production	production	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
43	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
50	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2130
# text = Cross-linking of FcR with immune complexes leads, first to activation of protein-tyrosine kinases.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	FcR	FcR	PROPN	NNP	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	first	first	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2131
# text = The molecular events that follow and that transduce signals from these receptors to the nucleus are still poorly defined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	follow	follow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	transduce	transduce	NOUN	NN	Number=Sing	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	still	still	ADV	RB	_	_	_	_	_
18	poorly	poorly	ADV	RB	_	_	_	_	_
19	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2132
# text = We have investigated the signal transduction pathway from Fc receptors that leads to gene activation and production of cytokines in monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
6	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	Fc	Fc	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2133
# text = Cross-linking of FcR, on the THP-1 monocytic cell line, by immune complexes resulted in both activation of the transcription factor NF-kappaB and interleukin 1 production.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	FcR	FcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
19	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2134
# text = These responses were completely blocked by tyrosine kinase inhibitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2135
# text = In contrast, expression of dominant negative mutants of Ras and Raf-1, in these cells, did not have any effect on FcR-mediated nuclear factor activation, suggesting that the mitogen-activated protein kinase (MAPK) signaling pathway was not used by these receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
23	any	any	DET	DT	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	FcR-mediated	FcR-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
49	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2136
# text = However, MAPK activation was easily detected by in vitro kinase assays, after FcR cross-linking with immune complexes.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	easily	easily	ADV	RB	_	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	FcR	Fcr	NOUN	NN	Number=Sing	_	_	_	_
16	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2137
# text = Using the specific MAPK/extracellular signal-regulated kinase kinase (MAPK kinase) inhibitor PD98059, we found that MAPK activation is necessary for FcR-dependent activation of the nuclear factor NF-kappaB.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MAPK	MAPK	NUM	CD	NumType=Card	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	PD98059	Pd98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	FcR-dependent	FcR-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2138
# text = These results strongly suggest that the signaling pathway from Fc receptors leading to expression of different genes important to leukocyte biology, initiates with tyrosine kinases and requires MAPK activation; but in contrast to other tyrosine kinase receptors, FcR-mediated MAPK activation does not involve Ras and Raf.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	leukocyte	leukocyte	VERB	VB	VerbForm=Inf	_	_	_	_
21	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
26	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	MAPK	Mapk	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
37	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	FcR-mediated	FcR-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
42	MAPK	MAPK	NOUN	NN	Number=Sing	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
47	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2139
# text = Document 003001109 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001109	003001109	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2140
# text = In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
17	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
33	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	abnormal	abnormal	VERB	VB	VerbForm=Inf	_	_	_	_
39	thymopoiesis	thymopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2141
# text = To understand the role of NF-kappa B complexes in T cell development and activation, we have generated transgenic mice in which RelA and c-Rel complexes were selectively inhibited in the T-lineage cells by specific expression of a trans-dominant form of I kappa B alpha.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
30	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	selectively	selectively	ADV	RB	_	_	_	_	_
33	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
47	form	form	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
50	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
51	B	b	PROPN	NNP	Number=Sing	_	_	_	_
52	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2142
# text = Transgene expression did not affect the thymic development, but led to lowered numbers of splenic T cells and to a dramatic decrease in the ex vivo proliferative response of splenic T lymphocytes.
1	Transgene	Transgene	PROPN	NNP	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	lowered	lower	ADJ	JJ	Degree=Pos	_	_	_	_
14	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	ex	ex	NOUN	NN	Number=Sing	_	_	_	_
27	vivo	vivo	ADP	IN	_	_	_	_	_
28	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2143
# text = Analysis of IL-2 and IL-2R alpha expression demonstrated that the perturbation of the proliferation response was not attributable to an abnormal expression of these genes.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	perturbation	perturbation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2144
# text = In contrast, expression of IL-4, IL-10, and IFN-gamma was strongly inhibited in the transgenic T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	strongly	strongly	ADV	RB	_	_	_	_	_
20	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2145
# text = The proliferative deficiency of the transgenic T cells was associated with an increased apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
3	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2146
# text = These results point out the involvement of NF-kappa B/Rel family proteins in growth signaling pathways by either regulating proteins involved in the IL-2 signaling or by functionally interfering with the cell cycle progression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	point	point	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	out	out	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	either	either	CCONJ	CC	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	by	by	SCONJ	IN	_	_	_	_	_
33	functionally	functionally	ADV	RB	_	_	_	_	_
34	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
39	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2147
# text = Document 003001110 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001110	003001110	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2148
# text = DNA-binding studies of the Epstein-Barr virus nuclear antigen 2 (EBNA-2): evidence for complex formation by latent membrane protein gene promoter-binding proteins in EBNA-2-positive cell lines.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBNA	EBNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
23	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
26	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2149
# text = The Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) protein is essential for the immortalization of human primary B cells by EBV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2150
# text = EBNA-2 trans-activates cellular and viral genes like CD23, c-fgr, latent membrane protein 1 (LMP1) and terminal protein 1 (TP1).
1	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	like	like	ADP	IN	_	_	_	_	_
12	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	fgr	fgr	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
18	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TP1	TP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2151
# text = Trans-activation of the TP1 promoter and of the BamHI C promoter has already been investigated in detail and appears to be mediated via protein-protein interactions and not by direct binding of EBNA-2 type A (of EBV type 1) to the DNA.
1	Trans-	Trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TP1	tP1	PROPN	NNP	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
11	C	C	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	already	already	ADV	RB	_	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	detail	detail	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
32	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	type	type	NOUN	NN	Number=Sing	_	_	_	_
38	A	a	SYM	SYM	_	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	of	of	ADP	IN	_	_	_	_	_
41	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
42	type	type	NOUN	NN	Number=Sing	_	_	_	_
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	DNA.	DNA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2152
# text = EBNA-2 is able to trans-activate the expression of the LMP gene in several cell lines.
1	EBNA	EBNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2153
# text = Various reports have delineated the cis-acting elements of the LMP promoter through which EBNA-2 mediates trans-activation.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	delineated	delineate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
20	trans-	trans-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2154
# text = To determine whether EBNA-2 also trans-activates the LMP promoter by protein-protein interactions, we performed a series of gel retardation assays and competition experiments with LMP promoter fragments of different sizes.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	trans	tran	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	series	series	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
29	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
36	sizes	size	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2155
# text = We determined that the protein-binding region on the LMP promoter was within a 42 bp fragment encompassing nucleotides -135 to -176 relative to the LMP transcriptional start site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	42	42	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
18	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	135	135	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	176	176	NUM	CD	NumType=Card	_	_	_	_
25	relative	relative	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	start	start	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2156
# text = None of the DNA fragments investigated indicated interaction of EBNA-2 with the DNA via protein-protein interactions.
1	None	none	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
6	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	indicated	indicated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2157
# text = No significant differences between EBNA-2-positive and EBNA-2-negative nuclear extracts could be seen in the gel retardation assay under conditions that clearly showed binding of EBNA-2A to the TP1 promoter.
1	No	no	DET	DT	_	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
24	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	clearly	clearly	ADV	RB	_	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	TP1	tP1	PROPN	NNP	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2158
# text = However, analysis of sucrose gradient fractions in the gel retardation assay provided evidence that the LMP promoter-binding proteins form a complex of higher M(r) in EBNA-2-positive cell extracts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	sucrose	sucrise	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	gradient	gradient	ADJ	JJ	Degree=Pos	_	_	_	_
7	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
11	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
13	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	form	from	ADP	IN	Typo=Yes	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
27	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	r	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2159
# text = These complexes were destroyed by detergent.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	destroyed	destroy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	detergent	detergent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2160
# text = We deduce from these results that EBNA-2-positive cells might indeed contain specific complexes bound to the LMP promoter which are, however, too labile to be detected in a standard gel retardation assay.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	deduce	deduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	indeed	indeed	ADV	RB	_	_	_	_	_
15	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
18	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	LMP	Lmp	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	too	too	ADV	RB	_	_	_	_	_
29	labile	labile	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
36	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
37	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
38	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2161
# text = Document 003001111 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001111	003001111	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2162
# text = Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.
1	Immune	Immune	PROPN	NNP	Number=Sing	_	_	_	_
2	hyperactivation	hyperactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2163
# text = Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
18	state	state	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	hyperactivation	hyperactivation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2164
# text = Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
36	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2165
# text = Expression of the HIV-1 transactivator
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2166
# text = Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	recapitulated	recapitulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	costimulation	costimulation	VERB	VB	VerbForm=Inf	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
20	plus	plus	CCONJ	CC	_	_	_	_	_
21	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2167
# text = IL-2 superinduction by
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	superinduction	superinduction	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_

# sent_id = 2168
# text = Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	exclusively	exclusively	ADV	RB	_	_	_	_	_
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	29	29	NUM	CD	NumType=Card	_	_	_	_
30	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
32	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
36	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2169
# text = Document 003001112 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001112	003001112	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2170
# text = Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3. CD14, a monocyte/macrophage receptor for the complex of LPS and LPS binding protein, is a differentiation marker for the monocyte/macrophage lineage.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-dihydroxyvitamin	-dihydroxyvitamin	ADJ	JJ	Degree=Pos	_	_	_	_
14	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
16	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
42	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2171
# text = We have analyzed the regulation of CD14 expression during 1 alpha,25-dihydroxyvitamin D3 (VitD3)-induced monocytic differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	14	14	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-dihydroxyvitamin	-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
14	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2172
# text = Using FACS, Northern blotting, and nuclear run-on analyses, we demonstrate that the up-regulation of CD14 expression during monocytic cell maturation is regulated mainly at the level of gene transcription, and that new protein synthesis is required for CD14 induction.
1	Using	use	AUX	VBG	VerbForm=Ger	_	_	_	_
2	FACS	Fac	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
5	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	on	on	ADP	IN	_	_	_	_	_
12	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	14	14	NUM	CD	NumType=Card	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	mainly	mainly	ADV	RB	_	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	CD14	CD14	NUM	CD	NumType=Card	_	_	_	_
48	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2173
# text = We have recently cloned the CD14 5' upstream sequence and demonstrated its tissue-specific promoter activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2174
# text = Using stable transfection of the monocytoid U937 cell line with a series of deletion mutants of the CD14 5' upstream sequence coupled to a reporter gene construct, we show that bp -128 to -70 is the critical region for the induction of CD14 expression.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
7	U937	U937	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	series	series	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	14	14	NUM	CD	NumType=Card	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	_
22	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
35	-128	-128	NUM	CD	NumType=Card	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	70	70	NUM	CD	NumType=Card	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
42	region	region	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	14	14	NUM	CD	NumType=Card	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2175
# text = This region contains two binding sites for the Sp1 transcription factor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2176
# text = A 3-bp mutation at the distal Sp1-binding site not only eliminates Sp1 interaction, but also abolishes most of the VitD3 induction of CD14 expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	eliminates	eliminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	abolishes	abolish	ADV	RB	_	_	_	_	_
22	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	14	14	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2177
# text = Electrophoretic mobility shift analysis does not detect a direct interaction of the CD14 distal Sp1-binding site with the vitamin D3 receptor and its partner, the retinoid X receptor.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	14	14	NUM	CD	NumType=Card	_	_	_	_
15	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
16	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-binding	-bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
22	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	partner	partner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
30	X	x	ADP	IN	_	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2178
# text = These data demonstrate that VitD3 induces CD14 indirectly through some intermediary factor, and suggest a critical role for Sp1 in this process.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	14	14	NUM	CD	NumType=Card	_	_	_	_
9	indirectly	indirectly	ADV	RB	_	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	some	some	DET	DT	_	_	_	_	_
12	intermediary	intermediary	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2179
# text = Document 003001113 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001113	003001113	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2180
# text = Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
7	hemin-	hemin-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
10	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	K562	K562	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2181
# text = Acquisition of heat shock factor 2 (HSF2) DNA binding activity is accompanied by induced transcription of heat shock genes in hemin-treated K562 cells undergoing erythroid differentiation.
1	Acquisition	Acquisition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
4	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
20	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	hemin	hemin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	K562	K562	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	undergoing	undergoing	VERB	VBG	VerbForm=Ger	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2182
# text = Previous studies revealed that HSF2 consists of two alternatively spliced isoforms, HSF2-alpha and HSF2-beta, whose relative abundance is developmentally regulated and varies between different tissues.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	_
6	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	alternatively	alternatively	ADV	RB	_	_	_	_	_
10	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	HSF2	Hsf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
23	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	developmentally	developmentally	ADV	RB	_	_	_	_	_
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	varies	varies	NOUN	NNS	Number=Plur	_	_	_	_
29	between	between	ADP	IN	_	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2183
# text = To investigate whether the molar ratio of HSF2-alpha and HSF2-beta isoforms is crucial for the activation of HSF2 and whether the HSF2 isoforms play functionally distinct roles during the hemin-mediated erythroid differentiation, we generated cell clones expressing different levels of HSF2-alpha and HSF2-beta.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molar	molar	ADJ	JJ	Degree=Pos	_	_	_	_
6	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	whether	whether	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	_
27	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	functionally	functionally	ADV	RB	_	_	_	_	_
30	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
31	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
32	during	during	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	hemin-	hemin-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
43	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
44	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	HSF2	Hsf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2184
# text = We show that in parental K562 cells, the HSF2-alpha isoform is predominantly expressed and HSF2 can be activated upon hemin treatment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
6	K562	K562	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	predominantly	predominantly	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	HSF2	Hsf2	NUM	CD	NumType=Card	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	hemin	hemin	ADJ	JJ	Degree=Pos	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2185
# text = In contrast, when HSF2-beta is expressed at levels exceeding those of endogenous HSF2-alpha, the hemin-induced DNA binding activity and transcription of heat shock genes are repressed, whereas overexpression of HSF2-alpha results in an enhanced hemin response.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	when	when	ADV	WRB	PronType=Int	_	_	_	_
5	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	exceeding	exceed	VERB	VBG	VerbForm=Ger	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	hemin-	hemin-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
30	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	whereas	whereas	SCONJ	IN	_	_	_	_	_
36	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
41	results	result	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2186
# text = Furthermore, the hemin-induced accumulation of globin, known as a marker of erythroid differentiation, is decreased in cells overexpressing HSF2-beta.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hemin-	hemin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
23	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2187
# text = We suggest that HSF2-beta acts as a negative regulator of HSF2 activity during hemin-mediated erythroid differentiation of K562 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	hemin-	hemin-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	K562	K562	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2188
# text = Document 003001114 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001114	003001114	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2189
# text = Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2190
# text = The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
6	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2191
# text = Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2192
# text = The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	nor	nor	CCONJ	CC	_	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
39	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2193
# text = Document 003001115 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001115	003001115	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2194
# text = Involvement of intracellular Ca2+ in oxidant-induced NF-kappa B activation.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2195
# text = In human Jurkat T cells and its subclone Wurzburg cells oxidant challenge elevated [Ca2+]i by mobilizing Ca2+ from intracellular stores.
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
8	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	subclone	subclone	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	Wurzburg	Wurzburg	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
13	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	_
14	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	mobilizing	mobilize	VERB	VBG	VerbForm=Ger	_	_	_	_
22	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	stores	store	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2196
# text = In Jurkat cells this effect was rapid and transient, but in Wurzburg cells the response was slow and sustained.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Wurzburg	Wurzburg	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	sustained	sustain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2197
# text = H2O2-induced NF-kappaB activation in Wurzburg cells was not influenced by the presence of extracellular EGTA but was totally inhibited in cells that were loaded with esterified EGTA.
1	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	EGTA	EGTA	PROPN	NNP	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	totally	totally	ADV	RB	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	loaded	load	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	esterified	esterify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	EGTA	EGTa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2198
# text = In Jurkat cells that are not sensitive to H2O2-induced NF-kappaB activation, H2O2 potentiated NF-kappaB activation in the presence of sustained high [Ca2+]i following thapsigargin treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	H2O2	h2o2	PART	TO	Abbr=Yes	_	_	_	_
17	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
28	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
31	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
34	thapsigargin	thapsigargin	ADJ	JJ	Degree=Pos	_	_	_	_
35	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2199
# text = NF-kappaB regulatory effect of alpha-lipoate and N-acetylcysteine appeared to be, at least in part, due to their ability to stabilize elevation of [Ca2+]i following oxidant challenge.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lipoate	lipoate	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	N-	N-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	_
13	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	at	at	ADV	RB	_	_	_	_	_
18	least	least	ADV	RBS	Degree=Sup	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	due	due	ADP	IN	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	stabilize	stabilize	VERB	VB	VerbForm=Inf	_	_	_	_
28	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
35	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
37	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2200
# text = Results of this study indicate that a sustained elevated [Ca2+]i is a significant factor in oxidant-induced NF-kappaB activation.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	indicate	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	sustained	sustain	ADJ	JJ	Degree=Pos	_	_	_	_
9	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2201
# text = Document 003001116 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001116	003001116	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2202
# text = Steel factor affects SCL expression during normal erythroid differentiation.
1	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2203
# text = Steel factor is one of the growth factors that controls the proliferation and differentiation of hematopoietic cells and SCL, also known as Tcl-5 or Tal-1, is a transcription factor involved in erythropoiesis.
1	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	Tcl	Tcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	erythropoiesis	erythropoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2204
# text = In this report, we studied the role of SCL in the proliferation of human peripheral blood burst-forming unit-erythroid (BFU-E) and the effects of Steel factor on SCL expression in proliferating erythroid cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	burst	burst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
21	unit-	unit-	X	GW	_	_	_	_	SpaceAfter=No
22	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	E	e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	SCONJ	IN	_	_	_	_	_
38	proliferating	proliferat	VERB	VBG	VerbForm=Ger	_	_	_	_
39	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2205
# text = BFU-E-derived colonies increase progressively in size, as determined by cell number, from day 7 to day 14 of culture, with the greatest increase in colony size (10-fold expansion) occurring between day 7 and day 10.
1	BFU	Bfu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-E	-e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	progressively	progressively	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	size	size	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	number	number	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	day	day	NOUN	NN	Number=Sing	_	_	_	_
19	7	7	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	day	day	NOUN	NN	Number=Sing	_	_	_	_
22	14	14	NUM	CD	NumType=Card	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	greatest	greatest	ADJ	JJS	Degree=Sup	_	_	_	_
29	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
32	size	size	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
37	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
40	between	between	ADP	IN	_	_	_	_	_
41	day	day	NOUN	NN	Number=Sing	_	_	_	_
42	7	7	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	day	day	NOUN	NN	Number=Sing	_	_	_	_
45	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2206
# text = SCL protein levels in BFU-E-derived cells were highest in day 7 cells and decreased progressively from day 7 to day 14 of culture, suggesting an association of SCL with erythroid proliferation.
1	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	E	e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	day	day	NOUN	NN	Number=Sing	_	_	_	_
15	7	7	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	progressively	progressively	ADV	RB	_	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	day	day	NOUN	NN	Number=Sing	_	_	_	_
22	7	7	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	day	day	NOUN	NN	Number=Sing	_	_	_	_
25	14	14	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	association	association	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	SCL	SCL	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
36	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2207
# text = In contrast, SCL mRNA levels did not decrease significantly between day 7 and day 14 cells, suggesting that posttranscriptional mechanisms are largely responsible for the decrease in SCL protein observed.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	SCL	Scl	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	day	day	NOUN	NN	Number=Sing	_	_	_	_
13	7	7	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	day	day	NOUN	NN	Number=Sing	_	_	_	_
16	14	14	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	largely	largely	ADV	RB	_	_	_	_	_
25	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2208
# text = The role of SCL in Steel factor-induced erythroid proliferation was then examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Steel	Steel	PROPN	NNP	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	then	then	ADV	RB	PronType=Dem	_	_	_	_
13	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2209
# text = In BFU-E-derived colonies cultured with Steel factor, colony size was significantly increased compared to control.
1	In	in	ADP	IN	_	_	_	_	_
2	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	E	e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
8	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
14	size	size	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	control	control	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2210
# text = In day 7 and day 10 erythroid precursors cultured with Steel factor, SCL protein was increased significantly compared to control.
1	In	in	ADP	IN	_	_	_	_	_
2	day	day	NOUN	NN	Number=Sing	_	_	_	_
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	day	day	NOUN	NN	Number=Sing	_	_	_	_
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
9	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	control	control	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2211
# text = The increase in SCL protein levels in early erythroid precursors stimulated with Steel factor suggests one mechanism through which Steel factor may enhance normal erythroid proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2212
# text = SCL mRNA levels assessed by Northern blot in day 7 cells did not increase significantly in response to Steel factor stimulation, suggesting that posttranscriptional mechanisms may also be important in the increase in SCL protein observed in response to Steel.
1	SCL	Scl	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	day	day	NOUN	NN	Number=Sing	_	_	_	_
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	Steel	Steel	VERB	VB	VerbForm=Inf	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
36	protein	protein	ADV	RB	_	_	_	_	_
37	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	Steel	Steel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2213
# text = Document 003001117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001117	003001117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2214
# text = Regulation of gene expression with double-stranded phosphorothioate oligonucleotides.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
10	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2215
# text = Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how these factors participate in cellular differentiation.
1	Alteration	Alteration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
16	how	how	ADV	WRB	PronType=Int	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2216
# text = The functions of these proteins can be antagonized by several methods, each with specific limitations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	antagonized	antagonize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	methods	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	each	each	DET	DT	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	limitations	limitation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2217
# text = Inhibition of sequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ds	d	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
20	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
28	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2218
# text = The phosphorothioate oligonucleotides specifically bound either octamer transcription factor or nuclear factor (NF)-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
3	oligonucleotides	oligonucleotide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	specifically	specifically	ADV	RB	_	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2219
# text = The modified oligonucleotides accumulated in cells more effectively than standard ds oligonucleotides and modulated gene expression in a specific manner.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
4	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	effectively	effectively	ADV	RB	_	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
11	ds	d	NOUN	NNS	Number=Plur	_	_	_	_
12	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2220
# text = Octamer-dependent activation of a reporter plasmid or NF-kappa B-dependent activation of the human immunodeficiency virus (HIV) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line.
1	Octamer	Octamer	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	when	when	ADV	WRB	PronType=Int	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
31	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
32	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	transiently	transiently	ADV	RB	_	_	_	_	_
38	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2221
# text = Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 (IL-2) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	phosphorothioate	phosphorothioate	ADJ	JJ	Degree=Pos	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
9	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
28	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2222
# text = The ds phosphorothioate oligonucleotides probably compete for binding of specific transcription factors and may provide anti-viral, immunosuppressive, or other therapeutic effects.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ds	d	NOUN	NNS	Number=Plur	_	_	_	_
3	phosphorothioate	phosphorothioate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	probably	probably	ADV	RB	_	_	_	_	_
6	compete	compete	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	anti-viral	anti-viral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2223
# text = Document 003001118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001118	003001118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2224
# text = Signals and nuclear factors that regulate the expression of interleukin-4 and interleukin-5 genes in helper T cells.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	helper	helper	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2225
# text = Mouse thymoma line EL-4 cells produce cytokines such as interleukin (IL)-2, IL-3, IL-4, IL-10, and granulocyte-macrophage colony-stimulating factor in response to phorbol 12-myristate 13-acetate (PMA).
1	Mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
2	thymoma	thymoma	NOUN	NN	Number=Sing	_	_	_	_
3	line	line	NOUN	NN	Number=Sing	_	_	_	_
4	EL	el	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
43	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
46	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
48	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2226
# text = EL-4 cells also produce low levels of IL-5 when stimulated by PMA alone; however, cAMP greatly augments PMA-dependent IL-5 production.
1	EL	EL	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	_
13	when	when	ADV	WRB	PronType=Int	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
17	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
22	greatly	greatly	ADJ	JJ	Degree=Pos	_	_	_	_
23	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2227
# text = A transient transfection assay revealed that two signals, PMA and cAMP, are required for optimal activation of the IL-5 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2228
# text = In contrast, cAMP almost completely inhibited the PMA-dependent activation of the endogenous IL-2 gene, as well as the transfected IL-2 promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cAMP	camp	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	completely	completely	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2229
# text = These results indicate that the IL-5 gene is positively regulated by cAMP in a manner opposite to that for the IL-2 gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	positively	positively	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
18	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2230
# text = One of the nuclear factors (NFs) that regulates the response of the IL-5 promoter to cAMP and PMA has properties similar to NF for activated t cell.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NFs	Nfs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
23	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	NF	NF	VERB	VB	VerbForm=Inf	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	t	t	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2231
# text = The P sequence of the IL-4 gene, defined as a responsive element for PMA and calcium ionophore (A23187), shares sequence similarity with the NF kappa B and the NF-activated T cell binding sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2232
# text = We attempted to determine whether NF(P), a nuclear factor specific for the P sequence, is related to NF-kappa B and nuclear factor for activated T cell (NF-AT).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	attempted	attempt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	At	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2233
# text = In electromobility shift assays both NF-kappa B (P65 or P65/P50 heterodimer) and NF-AT bound to the P sequence.
1	In	in	ADP	IN	_	_	_	_	_
2	electromobility	electromobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	B	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	P65	P65	NUM	CD	NumType=Card	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	P65	P65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
15	P50	P50	NUM	CD	NumType=Card	_	_	_	_
16	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	AT	AT	ADV	RB	_	_	_	_	_
22	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	P	p	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2234
# text = However, sequence specificity of NF-AT was more similar to that of NF(P), and only a small amount of P65 was detected in NF(P).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	P65	P65	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2235
# text = These results indicate that a component or components of NF-AT have the potential to reconstitute NF(P), whereas NF-kappa B alone does not account for NF(P) in Jurkat crude extract.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	component	component	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	components	component	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	AT	AT	PRON	WDT	PronType=Rel	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	_
29	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
39	crude	crude	NOUN	NN	Number=Sing	_	_	_	_
40	extract	extract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2236
# text = Taken together, these results suggest that NF-AT-like factors are involved in the regulation of IL-4 and IL-5 genes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT	AT	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2237
# text = Document 003001119 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001119	003001119	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2238
# text = Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression.
1	Octamer	Octamer	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2239
# text = Antibodies are produced exclusively in B lymphocytes.
1	Antibodies	Antibody	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	exclusively	exclusively	ADV	RB	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2240
# text = The expression of the antibody-encoding genes, the immunoglobulin
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2241
# text = (Ig) genes, is also restricted to B cells.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2242
# text = The octamer sequence ATGCAAAT is present in the promoter and the enhancer of Ig genes, and plays an important role in its tissue-specific expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	ATGCAAAT	Atgcaaat	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2243
# text = This sequence motif is a binding site for nuclear proteins, the so-called octamer transcription factors (Oct or OTF factors).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
14	-called	-call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	OTF	OTF	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2244
# text = The Oct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	types	type	NOUN	NNS	Number=Plur	_	_	_	_
12	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	so	so	ADV	RB	_	_	_	_	_
14	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	2B	2b	NOUN	NN	Number=Sing	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	mainly	mainly	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2245
# text = All three proteins show the same sequence specificity and binding affinity.
1	All	all	DET	DT	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2246
# text = It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell type-specific
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2247
# text = Oct factors, and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors.
1	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	there	there	PRON	EX	_	_	_	_	_
7	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	qualitative	qualitative	ADJ	JJ	Degree=Pos	_	_	_	_
12	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2248
# text = Recently, a number of other octamer factor variants were identified.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	number	number	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2249
# text = Many of these may be created by alternative splicing of a primary transcript of one Oct factor gene and may serve a specific function in the fine tuning of gene expression.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	created	create	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
9	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	fine	fine	ADJ	JJ	Degree=Pos	_	_	_	_
28	tuning	tuning	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2250
# text = Document 003001120 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001120	003001120	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2251
# text = Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2252
# text = Epstein-Barr virus (EBV), an oncogenic human herpesvirus, binds to and infects normal human B lymphocytes via CD21, the CR2 complement receptor.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CR2	Cr2	NOUN	NN	Number=Sing	_	_	_	_
27	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2253
# text = Studies of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-kappaB transcription factor, which, in turn, binds to and mediates transcriptional activation of Wp, the initial viral latent gene promoter.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	enable	enable	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
10	nonactivated	nonactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	noncycling	noncycl	VERB	VBG	VerbForm=Ger	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
17	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	events	event	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	_
29	on	on	ADV	RB	_	_	_	_	_
30	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	rapidly	rapidly	ADV	RB	_	_	_	_	_
36	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
54	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
60	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
61	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
62	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
63	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2254
# text = Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-kappaB-dependent intracellular signaling pathway which is required for infection.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2255
# text = Document 003001121 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001121	003001121	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2256
# text = An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
19	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
20	locus	locus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2257
# text = T cell receptor (TCR) alpha and delta gene segments are organized within a single genetic locus but are differentially regulated during T cell development.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	organized	organize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
17	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
18	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	differentially	differentially	ADV	RB	_	_	_	_	_
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	during	during	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2258
# text = An enhancer-blocking element (BEAD-1, for blocking element alpha/delta 1) was localized to a 2.0-kb region 3' of TCR delta gene segments and 5' of TCR alpha joining gene segments within this locus.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	blocking	blocking	NOUN	NN	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	BEAD	Bead	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	alpha/	alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	X	LS	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	2.0	2.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
30	delta	delta	PART	TO	Abbr=Yes	_	_	_	_
31	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	'	'	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	joining	join	VERB	VBG	VerbForm=Ger	_	_	_	_
40	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
41	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
42	within	within	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	locus.	locus.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2259
# text = BEAD-1 blocked the ability of the TCR delta enhancer (Edelta) to activate a promoter when located between the two in a chromatin-integrated construct.
1	BEAD	Bead	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
10	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Edelta	Edelta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	chromatin-	chromatin-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2260
# text = We propose that BEAD-1 functions as a boundary that separates the TCR alpha/delta locus into distinct regulatory domains controlled by Edelta and the TCR alpha enhancer, and that it prevents Edelta from opening the chromatin of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	BEAD	Bead	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	boundary	boundary	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	separates	separate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
15	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	delta	delof	PROPN	NNP	Number=Sing	_	_	_	_
17	locus	locus	ADV	RB	_	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
22	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	Edelta	Edelta	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	Edelta	Edelta	PROPN	NNP	Number=Sing	_	_	_	_
36	from	from	SCONJ	IN	_	_	_	_	_
37	opening	open	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
43	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
44	joining	join	VERB	VBG	VerbForm=Ger	_	_	_	_
45	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
46	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	VDJ	VDJ	PROPN	NNP	Number=Sing	_	_	_	_
49	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
50	at	at	ADP	IN	_	_	_	_	_
51	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
53	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	T	t	PROPN	NNP	Number=Sing	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2261
# text = Document 003001122 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001122	003001122	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2262
# text = Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation.
1	Coupling	Coupling	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
10	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2263
# text = The eukaryotic transcription factor NF-kappa B plays a central role in the induced expression of human immunodeficiency virus type 1 and in many aspects of the genetic program mediating normal T-cell activation and growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
26	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
30	program	program	NOUN	NN	Number=Sing	_	_	_	_
31	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2264
# text = The nuclear activity of NF-kappa B is tightly regulated from the cytoplasmic compartment by an inhibitory subunit called I kappa B alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	tightly	tightly	ADV	RB	_	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
20	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2265
# text = This cytoplasmic inhibitor is rapidly phosphorylated and degraded in response to a diverse set of NF-kappa B-inducing agents, including T-cell mitogens, proinflammatory cytokines, and viral transactivators such as the Tax protein of human T-cell leukemia virus type 1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rapidly	rapidly	ADV	RB	_	_	_	_	_
6	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
14	set	set	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
34	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
35	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
45	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
46	type	type	NOUN	NN	Number=Sing	_	_	_	_
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2266
# text = To explore these I kappa B alpha-dependent mechanisms for NF-kappa B induction, we identified novel mutants of I kappa
1	To	to	PART	TO	_	_	_	_	_
2	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
21	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2267
# text = B alpha that uncouple its inhibitory and signal-transducing functions in human T lymphocytes.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	uncouple	uncouple	NOUN	NN	Number=Sing	_	_	_	_
5	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2268
# text = Specifically, removal of the N-terminal 36 amino acids of I kappa B alpha failed to disrupt its ability to form latent complexes with NF-kappa B in the cytoplasm.
1	Specifically	specifically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	36	36	NUM	CD	NumType=Card	_	_	_	_
9	amino	amino	DET	DT	_	_	_	_	_
10	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
23	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
24	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2269
# text = However, this deletion mutation prevented the induced phosphorylation, degradative loss, and functional release of
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	degradative	degradative	ADJ	JJ	Degree=Pos	_	_	_	_
12	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
16	release	release	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_

# sent_id = 2270
# text = I kappa B alpha from NF-kappa B in Tax-expressing cells.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2271
# text = Alanine substitutions introduced at two serine residues positioned within this N-terminal regulatory region of I kappa B alpha also yielded constitutive repressors that escaped from Tax-induced turnover and that potently inhibited immune activation pathways for NF-kappa B induction, including those initiated from antigen and cytokine receptors.
1	Alanine	Alanine	NUM	CD	NumType=Card	_	_	_	_
2	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
3	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
7	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
8	positioned	position	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	escaped	escape	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	potently	potently	ADV	RB	_	_	_	_	_
34	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
46	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
47	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	from	from	ADP	IN	_	_	_	_	_
49	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
52	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2272
# text = In contrast, introduction of a phosphoserine mimetic at these sites rectified this functional defect, a finding consistent with a causal linkage between the phosphorylation status and proteolytic stability of this cytoplasmic inhibitor.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	phosphoserine	phosphoserine	NOUN	NN	Number=Sing	_	_	_	_
8	mimetic	mimetic	ADJ	JJ	Degree=Pos	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	rectified	rectify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
19	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	causal	causal	ADJ	JJ	Degree=Pos	_	_	_	_
23	linkage	linkage	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	status	status	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
34	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2273
# text = Together, these in vivo studies define a critical signal response domain in I kappa B alpha that coordinately controls the biologic activities of I kappa B alpha and NF-kappa B in response to viral and immune stimuli.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	I	I	PROPN	NNP	Number=Sing	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	ADP	IN	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	coordinately	coordinately	ADV	RB	_	_	_	_	_
20	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2274
# text = Document 003001123 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001123	003001123	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2275
# text = Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
13	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	either	either	CCONJ	CC	_	_	_	_	_
19	FK506	Fk506	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2276
# text = Proliferation and immunologic function of T lymphocytes are initiated by signals from the antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin.
1	Proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
22	FK506	Fk506	NOUN	NN	Number=Sing	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
28	analog	analog	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2277
# text = On the other hand, interleukin 2 (IL-2)-induced signals are blocked by rapamycin but not by FK506.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2278
# text = Remarkably, these two drugs inhibit each other's actions, raising the possibility that both act by means of a common immunophilin (immunosuppressant binding protein).
1	Remarkably	remarkably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
6	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	actions	action	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	raising	rais	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	act	act	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	means	means	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunophilin	immunophilin	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2279
# text = We find that the dissociation constant of rapamycin to the FK506 binding protein FKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to FKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
6	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	FK506	Fk506	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
17	=	=	SYM	SYM	_	_	_	_	_
18	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
19	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
26	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
33	=	=	SYM	SYM	_	_	_	_	_
34	0.4	0.4	NUM	CD	NumType=Card	_	_	_	_
35	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
41	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	_
42	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
43	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2280
# text = However, an excess of rapamycin is needed to revert FK506-mediated inhibition of IL-2 production, apoptosis, and transcriptional activation of NF-AT, a T-cell-specific transcription factor necessary for IL-2 gene activation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
11	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2281
# text = Similarly, an excess of FK506 is needed to revert rapamycin-mediated inhibition of IL-2-induced proliferation.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
11	rapamycin-	rapamycin-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2282
# text = The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the immunophilin FKBP.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
13	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	_
27	FKBP	Fkbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2283
# text = FKBP has been shown to catalyze the interconversion of the cis- and trans-rotamers of the peptidyl-prolyl amide bond of peptide substrates; here we show that rapamycin, like FK506, is a potent inhibitor of the rotamase activity of FKBP
1	FKBP	FKBP	SYM	NFP	_	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	catalyze	catalyze	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interconversion	interconversion	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	rotamers	rotamer	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	peptidyl	peptidyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	prolyl	prolyl	NOUN	NN	Number=Sing	_	_	_	_
22	amide	amide	NOUN	NN	Number=Sing	_	_	_	_
23	bond	bond	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
26	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	here	here	ADV	RB	PronType=Dem	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	like	like	ADP	IN	_	_	_	_	_
35	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
40	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	rotamase	rotamase	NOUN	NN	Number=Sing	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2284
# text = (Ki = 0.2 nM).
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ki	Ki	PROPN	NNP	Number=Sing	_	_	_	_
3	=	=	SYM	SYM	_	_	_	_	_
4	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
5	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2285
# text = Neither FKBP binding nor inhibition of rotamase activity of FKBP alone is sufficient to explain the biologic actions of these drugs.
1	Neither	neither	DET	DT	_	_	_	_	_
2	FKBP	Fkbp	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	nor	nor	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	rotamase	rotamase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_
11	alone	alone	ADV	RB	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
18	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2286
# text = Rather, these findings suggest that immunophilin bound to FK506 interferes with antigen receptor-induced signals, while rapamycin bound to the immunophilin interferes with IL-2-induced signals.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
11	interferes	interfere	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immunophilin	immunophilin	NOUN	NN	Number=Sing	_	_	_	_
25	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2287
# text = Document 003001124 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001124	003001124	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2288
# text = Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2289
# text = HTLV-1 infection causes an adult T cell leukemia in humans.
1	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
5	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2290
# text = The viral encoded protein tax, is thought to play an important role in oncogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	oncogenesis	oncogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2291
# text = Our previous data obtained from a tax transgenic mouse model revealed that tax transforms mouse fibroblasts but not thymocytes, despite comparable levels of tax expression in both tissues.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	model	model	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	transforms	transform	NOUN	NNS	Number=Plur	_	_	_	_
15	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
16	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	despite	despite	ADP	IN	_	_	_	_	_
22	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2292
# text = Constitutive tyrosine phosphorylation of a 130-kD protein(s) was observed in the tax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines, but not in thymocytes from Thy-tax transgenic mice.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	130	130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
18	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
30	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	ADV	RB	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	Thy	thy	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
40	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
41	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2293
# text = Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies, identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines.
1	Phosphotyrosine	Phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
6	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	set	set	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	p130	p130	NUM	CD	NumType=Card	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
24	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
26	fibroblastic	fibroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2294
# text = Phosphorylation of Jak2 in tax transformed cells resulted from high expression of IL-6.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2295
# text = Tyrosine phosphorylation of this protein could also be induced in Balb/c3T3 cells using a supernatant from the B line, which was associated with induction of cell proliferation.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Balb/	Balb/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	c3T3	c3T3	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2296
# text = Both phosphorylation and proliferation were inhibited by IL-6 neutralizing antibodies.
1	Both	both	DET	DT	_	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2297
# text = Constitutive phosphorylation of Jak kinases may facilitate tumor growth in both HTLV-1 infected human T cells and the transgenic mouse model.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
5	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2298
# text = Document 003001125 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001125	003001125	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2299
# text = Regulation of interleukin-1 beta production by glucocorticoids in human monocytes:
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2300
# text = the mechanism of action depends on the activation signal.
1	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2301
# text = Glucocorticoids are known to downregulate interleukin-1 beta production in monocytic cells by two different mechanims: direct inhibition of the gene transcription and destabilization of the preformed interleukin-1 beta mRNA.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	downregulate	downregulate	VERB	VB	VerbForm=Inf	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanims	mechanim	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	destabilization	destabilization	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	preformed	preform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2302
# text = Now we have examined the effect of the nature of the monocyte activating signal on these two inhibitory mechanims.
1	Now	now	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
13	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanims	mechanim	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2303
# text = When human monocytes were preincubated with dexamethasone for 1 hour and then stimulated either with bacterial lipopolysaccharide or phorbol myristate, it was found that dexamethasone inhibited the lipopolysaccharide-induced interleukin-1 beta protein production, but the phorbol myristate-induced production was increased 3-10 fold.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	then	then	ADV	RB	PronType=Dem	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
27	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
42	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	production	production	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	10	10	NUM	CD	NumType=Card	_	_	_	_
51	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2304
# text = This difference was also seen at the mRNA level.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2305
# text = When dexamethasone was added to the cultures 3 hours after the stimulators, it clearly decreased the interleukin-1 beta mRNA levels regardless of the stimulator used (although the effect was clearly weaker on the PMA-induced mRNA).
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	stimulators	stimulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	clearly	clearly	ADV	RB	_	_	_	_	_
16	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	SYM	SYM	_	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	regardless	regardless	ADV	RB	_	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
28	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	although	although	SCONJ	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	clearly	clearly	ADV	RB	_	_	_	_	_
35	weaker	weaker	ADJ	JJR	Degree=Cmp	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2306
# text = Thus these data suggest that the phorbol myristate-induced signal (prolonged protein kinase C activation?) cannot be inhibited by prior incubation with dexamethasone and it also protects the induced mRNA for the degradative action of dexamethasone.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	?	?	PUNCT	.	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
21	not	not	PART	RB	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
26	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	also	also	ADV	RB	_	_	_	_	_
32	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	degradative	degradative	ADJ	JJ	Degree=Pos	_	_	_	_
39	action	action	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2307
# text = Document 003001126 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001126	003001126	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2308
# text = Heat shock induces HIV-1 replication in chronically infected promyelocyte cell line OM10.1.
1	Heat	heat	ADJ	JJ	Degree=Pos	_	_	_	_
2	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	chronically	chronically	ADV	RB	_	_	_	_	_
10	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	OM	Om	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	10.1	10.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2309
# text = A long period of clinical latency before development of symptoms is characteristic of human immunodeficiency virus type 1 (HIV-1) infection.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
3	period	period	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
6	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
7	before	before	ADP	IN	_	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2310
# text = OM10.1, a promyelocyte cell line latently infected with HIV-1, has been developed as a model for studying the mechanism of viral latency and the activation of virus expression.
1	OM	Om	ADP	IN	_	_	_	_	SpaceAfter=No
2	10.1	10.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promyelocyte	promyelocyte	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	latently	latently	ADV	RB	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	model	model	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	SCONJ	IN	_	_	_	_	_
22	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2311
# text = We found that this latently infected cell line with heat shock at 42 degrees C for 2 h resulted in a high level of HIV-1 production without addition of any cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	latently	latently	ADV	RB	_	_	_	_	_
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	42	42	NUM	CD	NumType=Card	_	_	_	_
14	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	without	without	ADP	IN	_	_	_	_	_
30	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	any	any	DET	DT	_	_	_	_	_
33	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2312
# text = The mechanism of activation was analyzed by using anti-TNF-alpha antibody and various inhibitors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2313
# text = Although the TNF-alpha level in culture supernatants was below the sensitivity of an ELISA assay system, addition of anti-TNF-alpha antibody in culture medium could partially suppress the heat shock induced HIV-1 production.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
9	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	below	below	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
17	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
18	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
28	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
29	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
30	partially	partially	ADV	RB	_	_	_	_	_
31	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
34	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2314
# text = Staurosporine (PKC inhibitor), pentoxifylline (NF-kappa B inhibitor), and Ro5-3335 (HIV-1
1	Staurosporine	Staurosporine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
4	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	pentoxifylline	pentoxifylline	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Ro5-3335	Ro5-3335	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2315
# text = Tat inhibitor) also inhibited significantly the heat shock induced virus activation.
1	Tat	Tat	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
9	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2316
# text = In particular, staurosporine achieved approximately 90% inhibition of the HIV-1 antigen expression in heat shock-treated OM10.1 at a non-toxic concentration.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	staurosporine	staurosporine	PRON	PRP	_	_	_	_	_
5	achieved	achieve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	approximately	approximately	ADV	RB	_	_	_	_	_
7	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	%	%	SYM	NN	Number=Sing	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
19	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	OM10.1	Om10.1	NUM	CD	NumType=Card	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	non-toxic	non-toxic	ADJ	JJ	Degree=Pos	_	_	_	_
26	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2317
# text = Although the mechanism of HIV-1 activation with heat shock has not been fully elucidated yet, it is presumed PKC plays an important role in HIV-1 activation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	fully	fully	ADV	RB	_	_	_	_	_
16	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	yet	yet	ADV	RB	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	PKC	Pkc	PROPN	NNP	Number=Sing	_	_	_	_
23	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2318
# text = Thus, the present observations will provide a further insight into the pathogenesis of HIV-1 infections.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
6	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
7	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
10	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2319
# text = Document 003001127 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001127	003001127	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2320
# text = Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells.
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
12	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	study	study	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	allergen	allergen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2321
# text = BACKGROUND: Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
4	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	intimately	intimately	ADV	RB	_	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
14	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
15	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
19	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2322
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2323
# text = We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	T	t	NUM	CD	NumType=Card	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2324
# text = METHODS: Allergen-specific
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Allergen	Allergen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2325
# text = T cell clones and T cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the responses to various stimuli were determined.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
7	hybridomas	hybridoma	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	determined	determin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2326
# text = RESULTS: After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	After	after	ADP	IN	_	_	_	_	_
4	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	5	5	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
21	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
34	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2327
# text = Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	proliferated	proliferate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	mite	mite	NOUN	NN	Number=Sing	_	_	_	_
20	allergen	allergen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	mite	mite	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
35	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
38	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2328
# text = A human IL-5 promoter/enhancer luciferase gene construct transfected into IL-5-producing T cell clones was clearly transcribed after stimulation, indicating that the 515 base pair IL-5 gene segment upstream of the coding region was sufficient to respond to activating signals in human helper T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	clearly	clearly	ADV	RB	_	_	_	_	_
24	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	after	after	ADP	IN	_	_	_	_	_
26	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	515	515	NUM	CD	NumType=Card	_	_	_	_
32	base	base	NOUN	NN	Number=Sing	_	_	_	_
33	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
34	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	5	5	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
39	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
43	region	region	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
50	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
53	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2329
# text = The same gene segment was not transcribed in IL-5-nonproducing T cell clones, suggesting that human T cell IL-5 synthesis is regulated at the transcriptional level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	nonproducing	nonproduce	VERB	VBG	VerbForm=Ger	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2330
# text = Experiments with T cell hybridomas confirmed these findings and suggested that a unique transcription factor may be essential for human IL-5 gene transcription.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
5	hybridomas	hybridoma	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2331
# text = CONCLUSION: Enhanced IL-5 production by helper T cells seems to cause the eosinophilic inflammation of both atopic and nonatopic asthma.
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Enhanced	enhance	PROPN	NNP	Number=Sing	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2332
# text = Elucidation of IL-5-specific regulatory mechanisms may facilitate the development of novel treatments for allergic diseases associated with eosinophilic inflammation.
1	Elucidation	Elucidation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
16	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
19	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
23	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2333
# text = Document 003001128 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001128	003001128	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2334
# text = 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation.
1	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	deazaadenosine	deazaadenosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	S-adenosylhomocysteine	S-adenosylhomocysteine	ADJ	JJ	Degree=Pos	_	_	_	_
7	hydrolase	hydrolase	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2335
# text = Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	promotion	promotion	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2336
# text = Previously we reported that 3-deazaadenosine (DZA), a potent inhibitor and substrate for S-adenosylhomocysteine hydrolase inhibits bacterial lipopolysaccharide-induced transcription of tumor necrosis factor-alpha and interleukin-1beta in mouse macrophage RAW 264.7 cells.
1	Previously	previously	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	deazaadenosine	deazaadenosine	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	S-	S-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	adenosylhomocysteine	adenosylhomocysteine	NOUN	NN	Number=Sing	_	_	_	_
20	hydrolase	hydrolase	NOUN	NN	Number=Sing	_	_	_	_
21	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
22	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
23	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
39	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
40	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
41	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2337
# text = In this study, we demonstrate the effects of DZA on nuclear factor-kappaB (NF-kappaB) regulation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	DZA	DZa	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-kappaB	-kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2338
# text = DZA inhibits the transcriptional activity of NF-kappaB through the hindrance of p65 (Rel-A) phosphorylation without reduction of its nuclear translocation and DNA binding activity.
1	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	hindrance	hindrance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p65	p65	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	without	without	ADP	IN	_	_	_	_	_
22	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2339
# text = The inhibitory effect of DZA on NF-kappaB transcriptional activity is potentiated by the addition of homocysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	homocysteine	homocysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2340
# text = Taken together, DZA promotes the proteolytic degradation of IkappaBalpha, but not IkappaBbeta, resulting in an increase of DNA binding activity of NF-kappaB in the nucleus in the absence of its transcriptional activity in RAW 264.7 cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
40	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2341
# text = The reduction of IkappaBalpha by DZA is neither involved in IkappaB kinase complex activation nor modulated by the addition of homocysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	neither	neither	ADV	RB	_	_	_	_	_
9	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	IkappaB	Ikappab	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	nor	nor	CCONJ	CC	_	_	_	_	_
16	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	homocysteine	homocysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2342
# text = This study strongly suggests that DZA may be a potent drug for the treatment of diseases in which NF-kappaB plays a central pathogenic role, as well as a useful tool for studying the regulation and physiological functions of NF-kappaB.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
11	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	as	as	ADV	RB	_	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
33	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	SCONJ	IN	_	_	_	_	_
35	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
40	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2343
# text = Document 003001129 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001129	003001129	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2344
# text = Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.
1	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	NF-kappaB	NF-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Notch	notch	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	Notch	notch	PROPN	NNP	Number=Sing	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2345
# text = Jagged1 belongs to the DSL family of ligands for Notch receptors that control the proliferation and differentiation of various cell lineages.
1	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
2	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	DSL	dsl	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	Notch	notch	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2346
# text = However, little is known about the transcription factors that regulate its expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	about	about	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2347
# text = Here, we show that Jagged1 is a Rel/NF-kappaB-responsive gene.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Rel/	rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2348
# text = Both c-Rel and RelA induced jagged1 gene expression, whereas a mutant defective for transactivation did not.
1	Both	both	DET	DT	_	_	_	_	_
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	jagged	jag	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	defective	defective	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
19	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2349
# text = Importantly, jagged1 transcripts were also upregulated by endogenous NF-kappaB activation and this effect was inhibited by a dominant mutant of IkappaBalpha, a physiological inhibitor of NF-kappaB.
1	Importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	jagged	jag	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2350
# text = Cell surface expression of Jagged1 in c-Rel-expressing cell monolayers led to a functional interaction with lymphocytes expressing the Notch1/TAN-1 receptor.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-expressing	-expresse	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
13	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Notch1	notch1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	TAN	Tan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2351
# text = This correlated with the initiation of signaling downstream of Notch, as evidenced by increased levels of HES-1 transcripts in co-cultivated T cells and of CD23 transcripts in co-cultivated B cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
8	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Notch	notch	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HES	he	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	co-cultivated	co-cultivated	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
29	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	co-cultivated	co-cultivated	ADJ	JJ	Degree=Pos	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2352
# text = Consistent with its Rel/NF-kappaB-dependent induction, Jagged1 was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	Rel/NF	Rel/NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	highly	highly	ADV	RB	_	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	where	where	ADV	WRB	PronType=Rel	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	constitutively	constitutively	ADV	RB	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2353
# text = These results demonstrate that c-Rel can trigger the Notch signaling pathway in neighboring cells by inducing jagged1 gene expression, and suggest a role for Jagged1 in B-cell activation, differentiation or function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Notch	notch	NOUN	NN	Number=Sing	_	_	_	_
11	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	neighboring	neighbore	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	jagged	jag	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2354
# text = These findings also highlight the potential for an interplay between the Notch and NF-kappaB signaling pathways in the immune system.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Notch	notch	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2355
# text = Document 003001130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001130	003001130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2356
# text = IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability.
1	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	MRNA	MRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2357
# text = The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	highly	highly	ADV	RB	_	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	host	host	NOUN	NN	Number=Sing	_	_	_	_
22	defence	defence	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2358
# text = The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
5	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	referred	refer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	well	well	ADV	RB	Degree=Pos	_	_	_	_
22	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2359
# text = However, the mechanism(s) by which priming occurs is poorly defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	s	s	X	AFX	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	priming	priming	ADJ	JJ	Degree=Pos	_	_	_	_
11	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	poorly	poorly	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2360
# text = Using tumour necrosis factor (TNF) induction as a model, experiments were designed to analyse in detail the priming effect on the LPS response in human monocytes.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	analyse	analyse	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	detail	detail	NOUN	NN	Number=Sing	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2361
# text = Priming by IFN-gamma was primarily manifested at the level of TNF mRNA accumulation.
1	Priming	Prime	VERB	VBG	VerbForm=Ger	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	primarily	primarily	ADV	RB	_	_	_	_	_
8	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2362
# text = IFN-gamma pre-treatment affected the magnitude rather than the sensitivity of the LPS response.
1	IFN-	IFN-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
4	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
7	rather	rather	ADV	RB	_	_	_	_	_
8	than	than	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2363
# text = Priming occurred after several hours of treatment, and the primed state was induced by either IFN-gamma or GM-CSF, but not M-CSF.
1	Priming	Prime	PROPN	NNP	Number=Sing	_	_	_	_
2	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	after	after	ADP	IN	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
12	state	state	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2364
# text = Primed monocytes transcribed TNF mRNA at a higher rate than freshly isolated monocytes upon activation with LPS.
1	Primed	Prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
9	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
10	than	than	SCONJ	IN	_	_	_	_	_
11	freshly	freshly	ADV	RB	_	_	_	_	_
12	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2365
# text = The increased transcriptional rate correlated with a marked increase in nuclear factor-kappa B activity in these cells as determined by electrophoretic mobility shift assay using a consensus NF-kappa B oligonucleotide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	SCONJ	IN	_	_	_	_	_
21	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2366
# text = An additional significant finding was than TNF mRNA induced in primed cells was much more stable than in unprimed cells (T1/2 increased 6-8-fold).
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
4	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	than	than	ADP	IN	_	_	_	_	_
7	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	much	much	ADV	RB	_	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	T1	t1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2367
# text = Consistent with the increased mRNA stability, the duration of mRNA accumulation was longer following LPS stimulation in primed monocytes, in addition to being of greater magnitude.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	SCONJ	IN	_	_	_	_	_
25	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
28	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2368
# text = Finally, primed and unprimed cells possessed a differential sensitivity to the kinase inhibitor H-89.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	possessed	possess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	89	89	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2369
# text = H-89 substantially suppressed LPS-induced TNF mRNA accumulation in unprimed cells, but had no effect on primed monocytes following LPS stimulation.
1	H	h	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	89	89	NUM	CD	NumType=Card	_	_	_	_
4	substantially	substantially	ADV	RB	_	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
24	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2370
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2371
# text = Document 003001131 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001131	003001131	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2372
# text = Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis [see comments]
1	Immunosuppression	Immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	B	PROPN	NNP	Number=Sing	_	_	_	_
18	synthesis	synthesis	PROPN	NNPS	Number=Plur	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2373
# text = Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	among	among	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	most	most	ADV	RBS	_	_	_	_	_
6	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2374
# text = They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	known	known	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	immune	immune	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2375
# text = Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-kappa B) activation in mice and cultured cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2376
# text = This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	I	I	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	traps	traps	NOUN	NNS	Number=Plur	_	_	_	_
18	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2377
# text = Because NF-kappa B activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	pro-inflammatory	pro-inflammatory	VERB	VB	VerbForm=Inf	_	_	_	_
14	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	component	component	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2378
# text = Document 003001132 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001132	003001132	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2379
# text = Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.
1	Calcium	calcium	PROPN	NNP	Number=Sing	_	_	_	_
2	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2380
# text = The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
4	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
5	A	a	NOUN	NN	Number=Sing	_	_	_	_
6	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	normally	normally	ADV	RB	_	_	_	_	_
22	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2381
# text = When bound to cyclophilin, cyclosporin
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2382
# text = A binds and inactivates the key signalling intermediate calcineurin.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	inactivates	inactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	key	key	NOUN	NN	Number=Sing	_	_	_	_
7	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
8	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2383
# text = To identify potential cellular homologues of cyclosporin
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	homologues	homologue	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2384
# text = A that might regulate calcium signalling, we have cloned human genes encoding cyclophilin B-binding-proteins using the yeast two-hybrid system.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
4	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
5	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
6	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
15	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
25	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2385
# text = One gene product, when overexpressed in Jurkat T cells, specifically induced transcription from the interleukin-2 enhancer, by activating the T-cell-specific transcription factors NF-AT and NF-IL2A.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	IL2A	IL2A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2386
# text = This protein, termed calcium-signal modulating cyclophilin ligand (CAML), acts downstream of the TCR and upstream of calcineurin by causing an influx of calcium.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	calcium-	calcium-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	influx	influx	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2387
# text = CAML appears to be a new participant in the calcium-signal transduction pathway, implicating cyclophilin B in calcium signalling, even in the absence of cyclosporin.
1	CAML	caml	NOUN	NN	Number=Sing	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	participant	participant	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	calcium-	calcium-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	even	even	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2388
# text = Document 003001133 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001133	003001133	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2389
# text = Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	defensin	defensin	ADJ	JJ	Degree=Pos	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	phoP	phoP	NOUN	NN	Number=Sing	_	_	_	_
12	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
13	regulon	regulon	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Salmonella	Salmonella	PROPN	NNP	Number=Sing	_	_	_	_
16	typhimurium	typhimurium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2390
# text = The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	defensin	defensin	NOUN	NN	Number=Sing	_	_	_	_
3	sensitivities	sensitivity	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Salmonella	Salmonella	PROPN	NNP	Number=Sing	_	_	_	_
6	typhimurium	typhimurium	NOUN	NN	Number=Sing	_	_	_	_
7	strains	strain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phoP/	phop/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	component	component	ADJ	JJ	Degree=Pos	_	_	_	_
17	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
18	regulon	regulon	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	defensins	defensin	NOUN	NNS	Number=Plur	_	_	_	_
25	NP	NP	SYM	NFP	_	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	NP	Np	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2391
# text = Strains with mutations in either gene of the regulatory pair (phoP [transcriptional activator] or phoQ [membrane sensor kinase]) had increased sensitivities to defensin.
1	Strains	Strain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	either	either	DET	DT	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	phoP	phop	NOUN	NN	Number=Sing	_	_	_	_
13	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
21	sensor	sensor	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	sensitivities	sensitivity	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2392
# text = The predicted periplasmic domain of the PhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	periplasmic	periplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PhoQ	Phoq	PROPN	NNP	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	_
12	anionic	anionic	ADJ	JJ	Degree=Pos	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	cationic	cationic	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2393
# text = Because insertion mutations in phoP are polar on phoQ, we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	phoP	phop	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	polar	polar	ADJ	JJ	Degree=Pos	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	strains	strain	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PhoQ	Phoq	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	PhoP	phop	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
26	whether	whether	SCONJ	IN	_	_	_	_	_
27	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	_
30	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2394
# text = We found that resistance to defensin requires the function of both components of this regulatory system, because strains expressing PhoQ without PhoP were still markedly sensitive to defensins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	strains	strain	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	PhoQ	Phoq	PROPN	NNP	Number=Sing	_	_	_	_
22	without	without	ADP	IN	_	_	_	_	_
23	PhoP	phop	PROPN	NNP	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	still	still	ADV	RB	_	_	_	_	_
26	markedly	markedly	ADV	RB	_	_	_	_	_
27	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	defensins	defensin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2395
# text = This implied that a pag (phoP-activated gene) product is responsible for defensin resistance.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	implied	imply	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	pag	pag	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	phoP-	phoP-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	product	product	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	defensin	defensin	ADJ	JJ	Degree=Pos	_	_	_	_
16	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2396
# text = We also tested for the ability of defensins NP-1, NP-5, and HNP-1 to activate pag expression and found that these peptides have no effect.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	defensins	defensin	NOUN	NNS	Number=Plur	_	_	_	_
9	NP	NP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	NP	NP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	HNP	HNP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
23	pag	pag	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
30	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	no	no	DET	DT	_	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2397
# text = Defensin resistance is not the only virulence characteristic controlled by the PhoP-PhoQ regulon because mutations in pagC, as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc), had no effect on defensin resistance, even though they rendered the organism avirulent and deficient in survival within macrophages.
1	Defensin	Defensin	PROPN	NNP	Number=Sing	_	_	_	_
2	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
7	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
8	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	PhoP	phop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	PhoQ	Phoq	NOUN	NN	Number=Sing	_	_	_	_
15	regulon	regulon	NOUN	NN	Number=Sing	_	_	_	_
16	because	because	SCONJ	IN	_	_	_	_	_
17	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	pagC	pagC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	ones	one	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	phoP	phop	NOUN	NN	Number=Sing	_	_	_	_
28	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	pag	pag	NOUN	NN	Number=Sing	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
37	PhoPc	PhoPc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	no	no	DET	DT	_	_	_	_	_
42	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
43	on	on	ADP	IN	_	_	_	_	_
44	defensin	defensin	NOUN	NN	Number=Sing	_	_	_	_
45	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	even	even	ADV	RB	_	_	_	_	_
48	though	though	SCONJ	IN	_	_	_	_	_
49	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
50	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	organism	organism	NOUN	NN	Number=Sing	_	_	_	_
53	avirulent	avirulent	ADJ	JJ	Degree=Pos	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
58	within	within	ADP	IN	_	_	_	_	_
59	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2398
# text = The virulence defect conferred by mutations in the phoP-phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
3	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
4	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	phoP-	phop-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	component	component	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	completely	completely	ADV	RB	_	_	_	_	_
19	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	cationic	cationic	ADJ	JJ	Degree=Pos	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
37	typhimurium	typhimurium	NOUN	NN	Number=Sing	_	_	_	_
38	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
39	within	within	ADP	IN	_	_	_	_	_
40	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2399
# text = Document 003001134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001134	003001134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2400
# text = Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.
1	Histamine	Histamine	PRON	PRP	_	_	_	_	_
2	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
11	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	H2	h2	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2401
# text = We examined the effects of histamine and its agonists on the expression of the c-fos and c-myc proto-oncogenes at the transcriptional and translational levels in the human promonocytic U937 cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	histamine	histamine	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
20	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2402
# text = Histamine transiently increased cAMP and c-fos expression through H2 receptors.
1	Histamine	Histamine	ADV	RB	_	_	_	_	_
2	transiently	transiently	ADV	RB	_	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	H2	H2	NUM	CD	NumType=Card	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2403
# text = Dibutyryl cAMP also increased c-fos mRNA and protein, and levels remained elevated even after 12 hr of treatment.
1	Dibutyryl	Dibutyryl	PROPN	NNP	Number=Sing	_	_	_	_
2	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	even	even	ADV	RB	_	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	12	12	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2404
# text = Dose-dependence studies using histamine and dimaprit showed that the EC50 values for cAMP production and c-fos increase were similar, suggesting that cAMP might be involved in c-fos induction via H2 receptors.
1	Dose	Dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	histamine	histamine	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	dimaprit	dimaprit	NOUN	NN	Number=Sing	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EC50	EC50	NOUN	NN	Number=Sing	_	_	_	_
13	values	value	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
28	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
36	via	via	ADP	IN	_	_	_	_	_
37	H2	H2	NUM	CD	NumType=Card	_	_	_	_
38	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2405
# text = Furthermore, studies carried out using H7, a protein kinase A/protein kinase C inhibitor, blocked c-fos induction, whereas no effect was observed with bisindolylmaleimide, a specific protein kinase C inhibitor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	out	out	ADP	RP	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	H7	H7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	no	no	DET	DT	_	_	_	_	_
27	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	bisindolylmaleimide	bisindolylmaleimide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	C	c	NOUN	NN	Number=Sing	_	_	_	_
38	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2406
# text = No modification of c-myc expression could be detected on treatment with histamine or its analogues.
1	No	no	DET	DT	_	_	_	_	_
2	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	histamine	histamine	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2407
# text = Nevertheless, dibutyryl cAMP induced a down-regulation of the levels of this proto-oncogene.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	dibutyryl	dibutyryl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	down	down	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-regulation	-regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2408
# text = In addition, dibutyryl cAMP inhibited cell growth in a dose-dependent manner, whereas histamine failed to affect proliferation and differentiation of U937 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	dibutyryl	dibutyryl	ADJ	JJ	Degree=Pos	_	_	_	_
5	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	histamine	histamine	PRON	PRP	_	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
21	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	U937	U937	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2409
# text = Cells pretreated with dimaprit showed a decrease in the cAMP response to subsequent addition of H2 agonists, whereas the cAMP response to prostaglandin E2 remained unaltered.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	dimaprit	dimaprit	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
14	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	H2	H2	NUM	CD	NumType=Card	_	_	_	_
17	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	prostaglandin	prostaglandin	VERB	VB	VerbForm=Inf	_	_	_	_
25	E2	E2	NUM	CD	NumType=Card	_	_	_	_
26	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2410
# text = This homologous mechanism of H2 receptor desensitization was time dependent.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	H2	H2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	desensitization	desensitization	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2411
# text = These results indicate that histamine activates several mechanisms involved in the induction of differentiation, such as cAMP and c-fos production, but fails to promote differentiation of U937 cells, apparently due to the rapid desensitization of H2 receptors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	histamine	histamine	PRON	PRP	_	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	U937	U937	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	apparently	apparently	ADV	RB	_	_	_	_	_
35	due	due	ADP	IN	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
39	desensitization	desensitization	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	H2	H2	NUM	CD	NumType=Card	_	_	_	_
42	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2412
# text = Document 003001135 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001135	003001135	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2413
# text = Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	effector	effector	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Th2	th2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2414
# text = Transcriptional factors of the NFAT family play an important role in regulating the expression of several cytokine genes during the immune response, such as the genes for interleukin 2 (IL-2) and IL-4, among others.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	X	LS	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	among	among	ADP	IN	_	_	_	_	_
42	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2415
# text = Upon antigen stimulation, precursor CD4+ T helper (pTh) cells proliferate and differentiate into two populations of effector cells (eTh1 and eTh2), each one expressing a specific pattern of cytokines that distinguishes them from their precursors.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	pTh	pTh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	proliferate	proliferate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	each	each	DET	DT	_	_	_	_	_
30	one	one	NOUN	NN	Number=Sing	_	_	_	_
31	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	distinguishes	distinguish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2416
# text = eTh2 cells are the major source of IL-4, while gamma interferon is produced by eTh1 cells.
1	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	source	source	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	while	while	SCONJ	IN	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2417
# text = Here we have used reporter transgenic mice to show that DNA binding and transcriptional activities of NFAT are transiently induced during the differentiation of pTh cells into either eTh1 or eTh2 cells to mediate the expression of IL-2 as a common growth factor in both pathways.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NFAT	NFAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	transiently	transiently	ADV	RB	_	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	pTh	pTh	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	either	either	CCONJ	CC	_	_	_	_	_
29	eTh1	eTh1	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
44	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	both	both	DET	DT	_	_	_	_	_
48	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2418
# text = However, although NFAT DNA binding is similarly induced in both eTh1 and eTh2 cells upon antigen stimulation, only the NFAT complexes present in eTh2 cells are able to mediate high-level transcription, and relatively little NFAT transcriptional activity was induced in eTh1 cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	NFAT	NFAT	SCONJ	IN	_	_	_	_	_
5	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	similarly	similarly	ADV	RB	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
23	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	relatively	relatively	ADV	RB	_	_	_	_	_
39	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
40	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
41	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2419
# text = In contrast to activated pTh cells, neither eTh1 nor eTh2 cells produced significant IL-2 upon stimulation, but the high levels of NFAT transcriptional activities directly correlate with the IL-4 production induced in response to antigen stimulation in eTh2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	pTh	pTh	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	neither	neither	CCONJ	CC	_	_	_	_	_
9	eTh1	eTh1	PROPN	NNP	Number=Sing	_	_	_	_
10	nor	nor	CCONJ	CC	_	_	_	_	_
11	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	upon	upon	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
29	directly	directly	ADV	RB	_	_	_	_	_
30	correlate	correlate	ADV	RB	Degree=Pos	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	antigen	antigen	VERB	VB	VerbForm=Inf	_	_	_	_
42	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2420
# text = These data suggest that activated NFAT is involved in the effector function of eTh2 cells and that the failure of eTh1 cells to produce IL-4 in response to an antigen is due, at least partially, to a failure to induce high-level transcription of the IL-4 gene by NFAT.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	due	due	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	at	at	ADV	RB	_	_	_	_	_
37	least	least	ADV	RBS	Degree=Sup	_	_	_	_
38	partially	partially	ADV	RB	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
45	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	level	level	NOUN	NN	Number=Sing	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
53	4	4	NUM	CD	NumType=Card	_	_	_	_
54	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2421
# text = Regulation of NFAT could be therefore a critical element in the polarization to eTh1 or eTh2.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFAT	NFAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	therefore	therefore	ADV	RB	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	polarization	polarization	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2422
# text = Document 003001136 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001136	003001136	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2423
# text = Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
6	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2424
# text = The nuclear factor of kappaB (NF-kappaB) is a ubiquitous transcription factor that is key in the regulation of the immune response and inflammation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2425
# text = T cell receptor (TCR) cross-linking is in part required for activation of NF-kappaB, which is dependent on the phosphorylation and degradation of IkappaBalpha.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	part	part	NOUN	NN	Number=Sing	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2426
# text = By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	NOUN	NN	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	C	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	results	result	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
50	but	but	CCONJ	CC	_	_	_	_	_
51	not	not	ADV	RB	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	another	another	DET	DT	_	_	_	_	_
54	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
55	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	p90	p90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	rsk	rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2427
# text = We also demonstrate that the IKK complex, but not p90(rsk), is responsible for the in vivo phosphorylation of IkappaBalpha mediated by the co-activation of PKC and calcineurin.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	p90	p90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	rsk	rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	co-activation	co-activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2428
# text = Each second messenger is necessary, as inhibition of either one reverses the activation of the IKK complex and IkappaBalpha phosphorylation in vivo.
1	Each	each	DET	DT	_	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	reverses	reverse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2429
# text = Overexpression of dominant negative forms of IKKalpha and -beta demonstrates that only IKKbeta is the target for PKC and calcineurin.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	target	target	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2430
# text = These results indicate that within the TCR/CD3 signal transduction pathway both PKC and calcineurin are required for the effective activation of the IKK complex and NF-kappaB in T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TCR/	Tcr/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
25	complex	complex	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2431
# text = Document 003001137 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001137	003001137	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2432
# text = Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism.
1	Attenuated	Attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
22	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2433
# text = The Id family of helix-loop-helix proteins function as negative regulators of DNA binding, basic helix-loop-helix proteins in the regulation of cell growth and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Id	id	ADJ	JJ	Degree=Pos	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
19	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-loop	-loop	ADP	IN	_	_	_	_	SpaceAfter=No
21	-helix	-helix	ADJ	JJ	Degree=Pos	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2434
# text = We report here on the identification of a 17 kDa variant of the 14 kDa Id-3 protein termed Id-3L (long version) which possesses a unique 60 amino acid carboxy-terminus generated by read through of a 'coding intron' and alternative splicing.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	17	17	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	14	14	NUM	CD	NumType=Card	_	_	_	_
15	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
16	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3L	3L	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
26	version	version	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	possesses	possess	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
32	60	60	NUM	CD	NumType=Card	_	_	_	_
33	amino	amino	DET	DT	_	_	_	_	_
34	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
35	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
38	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	read	read	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
45	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
46	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	'	'	PUNCT	''	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
50	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2435
# text = Northern analysis revealed expression of a minor 1.1 kb
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
8	1.1	1.1	NUM	CD	NumType=Card	_	_	_	_
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2436
# text = Id-3L transcript together with the predominant 0.95 kb
1	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3L	3L	AUX	MD	VerbForm=Fin	_	_	_	_
4	transcript	transcriep	VERB	VB	VerbForm=Inf	_	_	_	_
5	together	together	ADV	RB	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	0.95	0.95	NUM	CD	NumType=Card	_	_	_	_
10	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2437
# text = Id-3 transcript in the majority of adult human tissues analysed.
1	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
12	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2438
# text = The variant Id-3L protein is functionally distinguishable from conventional Id-3 since in in vitro DNA mobility shift assays, it was greatly impaired in its ability to abrogate binding of the basic helix-loop-helix protein, E47, to an E box recognition sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
3	Id	id	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	3L	3L	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	functionally	functionally	ADV	RB	_	_	_	_	_
9	distinguishable	distinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
12	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	since	since	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	greatly	greatly	ADV	RB	_	_	_	_	_
27	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	abrogate	abrogate	VERB	VB	VerbForm=Inf	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
37	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	E47	E47	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	E	e	NOUN	NN	Number=Sing	_	_	_	_
46	box	box	NOUN	NN	Number=Sing	_	_	_	_
47	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
48	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2439
# text = Document 003001138 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001138	003001138	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2440
# text = Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2441
# text = MyD88, originally isolated as a myeloid differentiation primary response gene, is shown to act as an adaptor in interleukin-1 (IL-1) signaling by interacting with both the IL-1 receptor complex and IL-1 receptor-associated kinase (IRAK).
1	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	originally	originally	ADV	RB	_	_	_	_	_
4	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
30	by	by	SCONJ	IN	_	_	_	_	_
31	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	both	both	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	receptor-associated	receptor-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2442
# text = Mice generated by gene targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and cytokines in response to IL-1.
1	Mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
2	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	lack	lack	VERB	VB	VerbForm=Inf	_	_	_	_
8	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	_
9	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
10	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
21	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2443
# text = Increases in interferon-gamma production and natural killer cell activity in response to IL-18 are abrogated.
1	Increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
9	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	18	18	NUM	CD	NumType=Card	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2444
# text = In vivo Th1 response is also impaired.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADV	RB	_	_	_	_	_
3	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2445
# text = Furthermore, IL-18-induced activation of NF-kappaB and c-Jun N-terminal kinase (JNK) is blocked in MyD88-/- Th1-developing cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	MyD88	MyD88	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-/-	-/-	PUNCT	.	_	_	_	_	_
28	Th1	Th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-developing	-develop	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2446
# text = Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
12	component	component	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	well	well	ADV	RB	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	18	18	NUM	CD	NumType=Card	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2447
# text = Document 003001139 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001139	003001139	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2448
# text = Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	cross-talk	cross-talk	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2449
# text = The beta-casein promoter has been widely used to monitor the activation of STAT (signal transducer and activator of transcription)5 since STAT5 was originally found as a mediator of PRL-inducible beta-casein expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	widely	widely	ADV	RB	_	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	since	since	ADP	IN	_	_	_	_	_
26	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	originally	originally	ADV	RB	_	_	_	_	_
29	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
37	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2450
# text = However, not only is expression of the beta-casein gene regulated by STAT5 but it is also affected by other molecules such as glucocorticoid and Ras.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	not	not	ADV	RB	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ras	Ras	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2451
# text = In this report, we describe the transcriptional regulation of the beta-casein gene by cytokines in T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2452
# text = We have found that the beta-casein gene is expressed in a cytotoxic T cell line, CTLL-2, in response to interleukin-2 (IL-2), which activates STAT5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	CTLL	CTLL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2453
# text = While IL-4 does not activate STAT5, it induces expression of STAT5-regulated genes in CTLL-2, i.e. beta-casein, a cytokine-inducible SH2-containing protein (CIS), and oncostatin M (OSM), suggesting that STAT6 activated by IL-4 substitutes for the function of STAT5 in T cells.
1	While	while	SCONJ	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
11	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	i.e.	i.e.	X	FW	_	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	casein	casein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	CIS	CIS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	oncostatin	oncostatin	ADJ	JJ	Degree=Pos	_	_	_	_
42	M	m	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	OSM	OSM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
48	that	that	SCONJ	IN	_	_	_	_	_
49	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
50	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	4	4	NUM	CD	NumType=Card	_	_	_	_
55	substitutes	substitute	NOUN	NNS	Number=Plur	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	function	function	NOUN	NN	Number=Sing	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	T	T	PROPN	NNP	Number=Sing	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2454
# text = IL-2-induced beta-casein expression was enhanced by dexamethasone, and this synergistic effect of Dexamethasone requires the sequence between -155 and -193 in the beta-casein promoter.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
21	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	155	155	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	193	193	NUM	CD	NumType=Card	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2455
# text = Coincidentally, a deletion of this region enhanced the IL-2-induced expression of beta-casein.
1	Coincidentally	Coincidentally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	casein	casein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2456
# text = Expression of an active form of Ras, Ras(G12V), suppressed the IL-2-induced beta-casein and OSM gene expression, and the negative effect of Ras is mediated by the region between -105 and -193 in the beta-casein promoter.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	form	form	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	G12	G12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	V	V	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	OSM	OSm	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	region	region	NOUN	NN	Number=Sing	_	_	_	_
41	between	between	ADP	IN	_	_	_	_	_
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	105	105	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
46	193	193	NUM	CD	NumType=Card	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2457
# text = In apparent contradiction, expression of a dominant negative form of Ras, RasN17, also inhibited IL-2-induced activation of the promoter containing the minimal beta-casein STAT5 element as well as the promoters of CIS and OSM.
1	In	in	ADP	IN	_	_	_	_	_
2	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
3	contradiction	contradiction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	form	form	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	RasN	RasN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
34	STAT5	stat5	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	_
36	as	as	ADV	RB	_	_	_	_	_
37	well	well	ADV	RB	Degree=Pos	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	CIS	CIS	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	OSM	OSM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2458
# text = In addition, Ras(G12V) complemented signaling by an erythropoietin receptor mutant defective in Ras activation and augmented the activation of the beta-casein promoter by the mutant erythropoietin receptor signaling, suggesting a possible role of Ras in Stat5-mediated gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	G12	G12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	V	V	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	complemented	complement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
16	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
33	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
40	role	role	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2459
# text = These results collectively reveal a complex interaction of STAT5 with other signaling pathways and illustrate that regulation of gene expression requires integration of opposing signals.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	collectively	collectively	ADV	RB	_	_	_	_	_
4	reveal	reveal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	illustrate	illustrate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	opposing	oppos	ADJ	JJ	Degree=Pos	_	_	_	_
25	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2460
# text = Document 003001140 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001140	003001140	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2461
# text = Induction of transcription factors in human T lymphocytes by aspirin-like drugs.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2462
# text = Aspirin-like drugs (ALD) induce calcium mobilization, an essential component of T cell activation, but do not induce the biosynthesis of IL-2.
1	Aspirin	aspirin	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	like	like	ADP	IN	_	_	_	_	_
4	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ALD	ALD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
9	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
10	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
14	component	component	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	biosynthesis	biosynthesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2463
# text = To understand the extent to which ALD may mimic mitogenic stimulation, we studied cytoplasmic and nuclear signaling steps in ALD-treated T cells.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
19	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2464
# text = We found that ALD induce a transient activation of protein kinase (PKC) but have no effect (in comparison to anti-CD3 antibodies) on protein tyrosine phosphorylation nor on PCL gamma 1 tyrosine phosphorylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	in	in	ADP	IN	_	_	_	_	_
21	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
24	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
29	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
30	nor	nor	CCONJ	CC	_	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	PCL	pCl	NOUN	NN	Number=Sing	_	_	_	_
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2465
# text = ALD-induced calcium mobilization and PKC activation are independent of tyrosine protein kinase activity as shown by the lack of effect of herbimycin, a tyrosine-protein kinase-specific inhibitor.
1	ALD	ALd	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
5	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2466
# text = Although we detected no IL-2 mRNA in ALD-treated cells, the nuclei of these cells contain proteins capable of binding to three regulatory sequences in the IL-2 promoter region:
1	Although	although	SCONJ	IN	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	three	three	NUM	CD	NumType=Card	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2467
# text = NFAT, NF kappa B, and AP-1.
1	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2468
# text = These binding activities are expressed only in activated T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
3	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2469
# text = The expression of AP-1 depended on calcium mobilization and PKC activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	depended	depend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
10	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2470
# text = These data suggest that ALD cause transient but significant changes in T cell transmembrane signaling, although some events induced by stimulation with anti-CD3 antibodies are not induced by ALD.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	ALD	Ald	AUX	MD	VerbForm=Fin	_	_	_	_
6	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
7	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
15	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	events	event	NOUN	NNS	Number=Plur	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2471
# text = The signal is transmitted to the nucleus and induces DNA-binding activity by several transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	transmitted	transmit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2472
# text = However, the ALD stimulus is not capable of causing complete T cell activation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ALD	Ald	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2473
# text = Document 003001141 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001141	003001141	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2474
# text = Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
26	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2475
# text = A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	obstacle	obstacle	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	SCONJ	IN	_	_	_	_	_
5	understanding	understande	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	follow	follow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
14	arises	arise	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
20	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	costimulus	costimulus	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	TCR	Tcr	VERB	VB	VerbForm=Inf	_	_	_	_
26	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
29	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
35	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
38	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2476
# text = To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation.
1	To	to	PART	TO	_	_	_	_	_
2	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	problem	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	exploited	exploite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	via	via	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
30	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
35	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	observe	observe	VERB	VB	VerbForm=Inf	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	response	response	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2477
# text = Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	B7	B7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	measurable	measurable	ADJ	JJ	Degree=Pos	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2478
# text = However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	B7	B7	NUM	CD	NumType=Card	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	X	LS	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2479
# text = In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	superantigen	superantigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	without	without	ADP	IN	_	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	well	well	ADV	RB	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2480
# text = Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2481
# text = This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	chloroquine	chloroquine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
17	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2482
# text = In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	variably	variably	ADV	RB	_	_	_	_	_
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	chloroquine	chloroquine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2483
# text = These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	NOUN	NN	Number=Sing	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	both	both	DET	DT	_	_	_	_	_
38	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
39	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
42	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2484
# text = Document 003001142 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001142	003001142	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2485
# text = Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2486
# text = The lineage-restricted transcription factor GATA-1 is required for differentiation of erythroid and megakaryocytic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2487
# text = We have localized a 317 base pair cis-acting regulatory element, HS I, associated with a hematopoietic-specific
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	317	317	NUM	CD	NumType=Card	_	_	_	_
6	base	base	NOUN	NN	Number=Sing	_	_	_	_
7	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	HS	HS	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2488
# text = DNase I hypersensitive site, which lies approx.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	approx	approx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2489
# text = 3.7 kilobases upstream of the murine hematopoietic-specific GATA-1 IE promoter.
1	3.7	3.7	NUM	CD	NumType=Card	_	_	_	_
2	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
3	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	IE	ie	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2490
# text = HS I directs high-level expression of reporter GATA-1/lacZ genes to primitive and definitive erythroid cells and megakaryocytes in transgenic mice.
1	HS	h	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lacZ	lacz	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	definitive	definitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2491
# text = Comparative sequence analysis of HS I between human and mouse shows approx.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	human	human	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
11	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
12	approx	approx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2492
# text = 63% nucleotide identity with a more conserved core of 169 base pairs (86% identity).
1	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	%	%	SYM	NN	Number=Sing	_	_	_	_
3	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
9	core	core	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	169	169	NUM	CD	NumType=Card	_	_	_	_
12	base	base	NOUN	NN	Number=Sing	_	_	_	_
13	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	identity	identity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2493
# text = This core contains a GATA site separated by 10 base pairs from an E-box motif.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	base	base	NOUN	NN	Number=Sing	_	_	_	_
11	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	box	box	NOUN	NN	Number=Sing	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2494
# text = The composite motif binds a multi-protein hematopoietic-specific transcription factor complex which includes GATA-1, SCL/tal-1, E2A, Lmo2 and Ldb-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
3	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	multi-protein	multi-protein	ADJ	JJ	Degree=Pos	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Lmo2	Lmo2	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Ldb	Ldb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2495
# text = Point mutations of the GATA site abolishes HS I function, whereas mutation of the E-box motif still allows reporter gene expression in both lineages.
1	Point	point	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	HS	H	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	still	still	ADV	RB	_	_	_	_	_
20	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2496
# text = Strict dependence of HS I activity on a GATA site implies that assembly of a protein complex containing a GATA-factor, presumably GATA-1 or GATA-2, is critical to activating or maintaining its function.
1	Strict	strict	ADJ	JJ	Degree=Pos	_	_	_	_
2	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
5	I	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	presumably	presumably	ADV	RB	_	_	_	_	_
25	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	SCONJ	IN	_	_	_	_	_
36	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2497
# text = Further dissection of the 317 base pair region demonstrates that, whereas all 317 base pairs are required for expression in megakaryocytes, only the 5' 62 base pairs are needed for erythroid-specific reporter expression.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	317	317	NUM	CD	NumType=Card	_	_	_	_
6	base	base	NOUN	NN	Number=Sing	_	_	_	_
7	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	ADV	RB	_	_	_	_	_
13	all	all	DET	DT	_	_	_	_	_
14	317	317	NUM	CD	NumType=Card	_	_	_	_
15	base	base	NOUN	NN	Number=Sing	_	_	_	_
16	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	PUNCT	``	_	_	_	_	_
28	62	62	NUM	CD	NumType=Card	_	_	_	_
29	base	base	NOUN	NN	Number=Sing	_	_	_	_
30	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2498
# text = These findings demonstrate differential lineage requirements for expression within the HS I element.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
5	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
6	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HS	H	PROPN	NNPS	Number=Plur	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	element	element	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2499
# text = Document 003001143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001143	003001143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2500
# text = Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells.
1	Anti-rheumatic	Anti-rheumatic	ADJ	JJ	Degree=Pos	_	_	_	_
2	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
3	aurothioglucose	aurothioglucose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	factor-alpha-induced	factor-alpha-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	latently	latently	ADV	RB	_	_	_	_	_
14	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
15	OM	Om	ADP	IN	_	_	_	_	SpaceAfter=No
16	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Ach2	Ach2	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2501
# text = NF-kappaB is a potent cellular activator of HIV-1 gene expression.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2502
# text = Down-regulation of NF-kappaB activation is known to inhibit HIV replication from the latently infected cells.
1	Down	down	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	latently	latently	ADV	RB	Degree=Pos	_	_	_	_
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2503
# text = Gold compounds have been effectively used for many decades in the treatment of rheumatoid arthritis.
1	Gold	gold	NOUN	NN	Number=Sing	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	effectively	effectively	ADV	RB	_	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
9	decades	decade	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2504
# text = We previously reported that gold compounds, especially aurothioglucose (AuTG) containing monovalent gold ion, inhibited the DNA-binding of NF-kappaB in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
6	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	especially	especially	ADV	RB	_	_	_	_	_
9	aurothioglucose	aurothioglucose	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	AuTG	AuTG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	monovalent	monovalent	ADJ	JJ	Degree=Pos	_	_	_	_
15	gold	gold	NOUN	NN	Number=Sing	_	_	_	_
16	ion	ion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2505
# text = In this report we have examined the efficacy of the gold compound AuTG as an inhibitor of HIV replication in latently infected OM10.1 and Ach2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
12	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
13	AuTG	Autg	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	latently	latently	ADV	RB	_	_	_	_	_
22	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	OM10.1	Om10.1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Ach2	ach2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2506
# text = Tumor necrosis factor (TNF)-alpha-induced HIV-1 replication in OM10.1 or Ach2 cells was significantly inhibited by non-cytotoxic doses of AuTG (>10 microM in OM10.1 cells and >25 F.M in Ach2 cells), while 25 microM of the counter-anion thioglucose (TG) or gold compound containing divalent gold ion, HAuCl3, had no effect.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	OM10.1	OM10.1	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	Ach2	Ach2	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	non-cytotoxic	non-cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AuTG	AuTG	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	>10	>10	NUM	CD	NumType=Card	_	_	_	_
30	microM	microm	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	OM	Om	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	>	>	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	25	25	NUM	CD	NumType=Card	_	_	_	_
38	F.	F.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	M	m	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	Ach2	Ach2	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	while	while	SCONJ	IN	_	_	_	_	_
46	25	25	NUM	CD	NumType=Card	_	_	_	_
47	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	counter-anion	counter-anion	NOUN	NN	Number=Sing	_	_	_	_
51	thioglucose	thioglucose	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	TG	TG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	or	or	CCONJ	CC	_	_	_	_	_
56	gold	gold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
58	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
59	divalent	divalent	ADJ	JJ	Degree=Pos	_	_	_	_
60	gold	gold	NOUN	NN	Number=Sing	_	_	_	_
61	ion	ion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	HAuCl3	HAuCl3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
66	no	no	DET	DT	_	_	_	_	_
67	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2507
# text = The effect of AuTG on NF-kappaB-dependent gene expression was confirmed by a transient CAT assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AuTG	AuTG	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
18	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2508
# text = Specific staining as well as electron microscopic examinations revealed the accumulation of metal gold in the cells, supporting our previous hypothesis that gold ions could block NF-kappaB-DNA binding by a redox mechanism.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
3	as	as	ADV	RB	_	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	electron	electron	ADJ	JJ	Degree=Pos	_	_	_	_
7	microscopic	microscopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	examinations	examination	NOUN	NNS	Number=Plur	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	metal	metal	NOUN	NN	Number=Sing	_	_	_	_
14	gold	gold	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
20	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
21	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
22	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
25	ions	ion	NOUN	NNS	Number=Plur	_	_	_	_
26	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
27	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
36	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2509
# text = These observations indicate that the monovalent gold compound AuTG is a potentially useful drug for the treatment of patients infected with HIV.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monovalent	monovalent	ADJ	JJ	Degree=Pos	_	_	_	_
7	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
8	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
9	AuTG	Autg	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potentially	potentially	ADV	RB	_	_	_	_	_
13	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
14	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2510
# text = Document 003001144 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001144	003001144	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2511
# text = T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	filarial	filarial	ADJ	JJ	Degree=Pos	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2512
# text = The in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
4	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	filarial	filarial	ADJ	JJ	Degree=Pos	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Wuchereria	Wuchereria	PROPN	NNP	Number=Sing	_	_	_	_
17	banerofti	banerofti	NOUN	NN	Number=Sing	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2513
# text = Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04).
1	Circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	filaria	filaria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	lymphatic	lymphatic	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LP	LP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
18	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
21	HUVEC	Huvec	NOUN	NN	Number=Sing	_	_	_	_
22	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	did	do	NOUN	NN	Number=Sing	_	_	_	_
25	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
29	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	MF	MF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	p	NOUN	NN	Number=Sing	_	_	_	_
36	=	=	SYM	SYM	_	_	_	_	_
37	0.04	0.04	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2514
# text = In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MF	MF	PROPN	NNP	Number=Sing	_	_	_	_
6	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
7	where	where	ADV	WRB	PronType=Rel	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	filarial	filarial	ADJ	JJ	Degree=Pos	_	_	_	_
20	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	LP	Lp	NOUN	NN	Number=Sing	_	_	_	_
26	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	significantly	significantly	ADV	RB	_	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	P	p	SYM	NFP	_	_	_	_	_
31	=	=	SYM	SYM	_	_	_	_	_
32	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
35	than	than	ADP	IN	_	_	_	_	_
36	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
41	media	media	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2515
# text = In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	six	six	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	seven	seven	NUM	CD	NumType=Card	_	_	_	_
5	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
6	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	VLA-4/	Vla-4/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2516
# text = Document 003001145 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001145	003001145	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2517
# text = Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	lysophosphatidylcholine	lysophosphatidylcholine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2518
# text = The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiator	initiator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2519
# text = Both conditions are promoted by lysophosphatidylcholine (lysoPC).
1	Both	both	DET	DT	_	_	_	_	_
2	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	lysophosphatidylcholine	lysophosphatidylcholine	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lysoPC	lysoPC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2520
# text = We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	micromol/	micromol/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	L	l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	dependently	dependently	ADV	RB	_	_	_	_	_
19	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2521
# text = Lysophosphatidylethanolamine (lysoPE) and other lysophospholipids did not affect LPS-induced TF activity of human monocytes.
1	Lysophosphatidylethanolamine	Lysophosphatidylethanolamine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	lysoPE	lysoPE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	lysophospholipids	lysophospholipid	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2522
# text = TF antigen expression as elicited by LPS was also lowered by lysoPC.
1	TF	Tf	ADP	IN	_	_	_	_	_
2	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	lowered	lower	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2523
# text = Phospholipid analyses indicated a selective increase in the lysoPC content of the monocytes after preincubation with the lysophospholipid.
1	Phospholipid	Phospholipid	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lysoPC	lysoPC	NOUN	NN	Number=Sing	_	_	_	_
10	content	content	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lysophospholipid	lysophospholipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2524
# text = LysoPC inhibited the TF activity of Mono Mac-6 cells to a similar extent as in the monocytes.
1	LysoPC	LysoPC	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
8	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2525
# text = LPS binding to plasma membrane receptors and internalization of LPS into monocytes were not affected by lysoPC.
1	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	internalization	internalization	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	lysoPC	lysoPC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2526
# text = In contrast, LPS-mediated nuclear binding of nuclear factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2527
# text = Induction of TF mRNA expression by LPS tended to be partially reduced by the lysophospholipid.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
8	tended	tend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	partially	partially	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	lysophospholipid	lysophospholipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2528
# text = Preincubation with lysoPC increased monocytic cAMP levels.
1	Preincubation	Preincubation	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2529
# text = Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	adenylyl	adenylyl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	deoxy	deoxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
15	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
16	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	reversed	reverse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2530
# text = In conclusion, lysoPC markedly decreases LPS-mediated TF expression of human monocytes, the effect probably being mediated by both transcriptional and posttranscriptional mechanisms.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	_
5	markedly	markedly	ADV	RB	_	_	_	_	_
6	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	probably	probably	ADV	RB	_	_	_	_	_
19	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2531
# text = LysoPC may thus attenuate activation of coagulation during inflammation and atherosclerosis.
1	LysoPC	Lysopc	NOUN	NN	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	attenuate	attenuate	VERB	VB	VerbForm=Inf	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2532
# text = Document 003001146 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001146	003001146	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2533
# text = IL-2-independent activation and proliferation in human T cells induced by CD28.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2534
# text = Although the role of CD28 in T cell costimulation is firmly established, the mechanisms by which it exerts its costimulatory actions are less clear.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	firmly	firmly	ADV	RB	_	_	_	_	_
12	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
25	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2535
# text = In many circumstances it is difficult to distinguish the effects of CD28 from subsequent actions of cytokines, such as IL-2, on T cell proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
15	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2536
# text = Here, we report a model of CD28 costimulation using PMA plus the natural ligand CD80 that resulted in very limited stimulation of IL-2, as evidenced by both cytokine production and IL-2 promoter stimulation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	model	model	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
9	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
10	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
12	plus	plus	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
16	CD80	CD80	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	very	very	ADV	RB	_	_	_	_	_
21	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2537
# text = Promoter assays revealed CD28-dependent effects on both NF-kappaB and AP-1, but not on NF-AT or the intact IL-2 promoter.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2538
# text = In addition, T cell proliferation was completely resistant to the actions of the immunosuppressant cyclosporin A (CsA).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
16	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
17	A	A	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2539
# text = Moreover T cell proliferation was unaffected by the addition of blocking Abs to both IL-2 and the IL-2 receptor, demonstrating that this form of costimulation by CD28 was independent of IL-2.
1	Moreover	moreover	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
12	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	form	form	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2540
# text = We also investigated the effects of stimulating T cell blasts with CD80 alone and found that there was a limited requirement for IL-2 in this system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_
13	alone	alone	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	there	there	PRON	EX	_	_	_	_	_
18	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
21	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2541
# text = We conclude that CD28 costimulation can cause substantial T cell proliferation in the absence of IL-2, which is driven by a soluble factor independent of NF-AT transactivation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
5	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
8	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AT	at	ADP	IN	_	_	_	_	_
32	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2542
# text = Document 003001147 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001147	003001147	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2543
# text = Human neutrophils express GH-N gene transcripts and the pituitary transcription factor Pit-1b.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	GH	Gh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	N	n	CCONJ	CC	Abbr=Yes	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	pituitary	pituitary	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2544
# text = Since GH stimulates the development and function of granulocytes, we investigated the expression of GH in granulocyte subsets.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	GH	Gh	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
19	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2545
# text = By immunocytochemistry, 25 +/- 7% of the human neutrophils were shown to express immunoreactive GH, whereas eosinophils were negative.
1	By	by	ADP	IN	_	_	_	_	_
2	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	25	25	NUM	CD	NumType=Card	_	_	_	_
5	+/-	+/-	SYM	SYM	_	_	_	_	_
6	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
16	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	GH	Gh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2546
# text = Reversed transcription (RT)-PCR analysis demonstrated GH mRNA in neutrophils.
1	Reversed	reversed	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	PCR	Pcr	ADJ	JJ	Degree=Pos	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	GH	Gh	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2547
# text = Restriction analysis revealed that neutrophils express the GH-N gene but not the GH-V gene.
1	Restriction	restriction	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
6	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GH	GH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	N	N	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GH	GH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	V	V	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2548
# text = Furthermore, we demonstrated by western blot analysis that neutrophils express an alternatively spliced variant of the pituitary transcription factor Pit-1, designated Pit-1b.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	western	western	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	neutrophils	neutrophil	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	alternatively	alternatively	ADV	RB	_	_	_	_	_
14	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pituitary	pituitary	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-1b	-1b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2549
# text = Document 003001148 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001148	003001148	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2550
# text = Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	growth-	growth-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
7	MCM5	MCM5	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	MCM6	MCM6	PROPN	NNP	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2551
# text = Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle.
1	Initiation	Initiation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MCM	MCm	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	ensuring	ensure	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	occurs	occur	ADV	RB	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	once	once	ADV	RB	NumType=Mult	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2552
# text = Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	MCM	MCM	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	unlike	unlike	ADP	IN	_	_	_	_	_
17	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
22	levels	levels	NOUN	NNS	Number=Plur	_	_	_	_
23	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	G1/S	G1/S	PROPN	NNP	Number=Sing	_	_	_	_
26	boundary	boundary	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2553
# text = In this study, we examined the transcriptional activities of isolated human MCM gene promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	MCM	MCm	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2554
# text = Human MCM5 and MCM6 promoters with mutation in the E2F sites failed in promoter regulation following serum stimulation and exogenous E2F expression.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	MCM5	MCM5	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	MCM6	MCM6	NUM	CD	NumType=Card	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	F	f	PROPN	NNP	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	failed	fail	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
18	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
22	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2555
# text = In addition, we identified a novel E2F-like sequence in human MCM6 promoter which cooperates with the authentic E2F sites in E2F-dependent regulation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	E2F	E2F	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	MCM6	Mcm6	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	authentic	authentic	ADJ	JJ	Degree=Pos	_	_	_	_
21	E2	e2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	F	for	PROPN	NNP	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2556
# text = Forced expression of E2F1 could induce expression of all members of the endogenous MCM genes in rat embryonal fibroblast REF52 cells.
1	Forced	forced	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E2F1	E2f1	PROPN	NNP	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
14	MCM	MCm	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
18	embryonal	embryonal	ADV	RB	_	_	_	_	_
19	fibroblast	fibroblast	ADV	RBS	Degree=Sup	_	_	_	_
20	REF52	Ref52	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2557
# text = Our results demonstrated that the growth-regulated expression of mammalian MCM5 and MCM6 genes, and presumably other MCM members, is primarily regulated by E2F through binding to multiple E2F sites in the promoters.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
12	MCM5	Mcm5	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	MCM6	Mcm6	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	presumably	presumably	ADV	RB	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	MCM	MCm	NOUN	NN	Number=Sing	_	_	_	_
21	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	primarily	primarily	ADV	RB	_	_	_	_	_
25	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	_
28	through	through	SCONJ	IN	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	multiple	multiple	VERB	VB	VerbForm=Inf	_	_	_	_
32	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	F	f	PROPN	NNP	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2558
# text = Document 003001149 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001149	003001149	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2559
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2560
# text = A inhibits monocyte tissue factor activation in cardiac transplant recipients.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
3	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
9	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
10	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2561
# text = BACKGROUND: Fibrin deposition and thrombosis have been implicated in both allograft rejection and vasculopathy after cardiac transplantation.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Fibrin	Fibrin	ADJ	JJ	Degree=Pos	_	_	_	_
4	deposition	deposition	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	thrombosis	thrombosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	_
13	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
18	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2562
# text = Because monocytes play a pivotal role in the pathophysiology of intravascular coagulation activation through their ability to synthesize tissue factor (TF), we asked (1) whether monocyte TF activation occurs in cardiac transplant recipients and (2) whether monocyte TF expression is affected by treatment with cyclosporin A (CsA).
1	Because	because	SCONJ	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	intravascular	intravascular	ADJ	JJ	Degree=Pos	_	_	_	_
12	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	synthesize	synthesize	VERB	VB	VerbForm=Inf	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	asked	ask	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	1	1	X	LS	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	whether	whether	SCONJ	IN	_	_	_	_	_
31	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
32	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
37	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
38	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	2	2	X	LS	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	whether	whether	SCONJ	IN	_	_	_	_	_
44	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	_
45	TF	TF	ADP	RP	_	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
53	A	a	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2563
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2564
# text = We measured levels of TF activity in peripheral blood mononuclear cells and highly purified monocytes/macrophages from 10 consecutive cardiac transplant recipients and 10 healthy control subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	consecutive	consecutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	cardiac	cardiac	NOUN	NN	Number=Sing	_	_	_	_
22	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
23	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
27	control	control	NOUN	NN	Number=Sing	_	_	_	_
28	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2565
# text = TF activity generated by both unstimulated and endotoxin-stimulated cells was significantly higher in transplant recipients than in control subjects (P<.05).
1	TF	Tf	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	endotoxin-	endotoxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	transplant	transplant	ADJ	JJ	Degree=Pos	_	_	_	_
16	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	.05	.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2566
# text = Increased monocyte TF expression in transplant recipients was shown to be adversely affected by treatment with CsA: TF induction was markedly reduced by CsA serum concentrations reaching peak CsA drug levels.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
3	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	transplant	transplant	ADJ	JJ	Degree=Pos	_	_	_	_
7	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	adversely	adversely	ADV	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	TF	Tf	ADJ	JJ	Degree=Pos	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	markedly	markedly	ADV	RB	_	_	_	_	_
23	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
26	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
27	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
28	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
29	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
30	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
31	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
32	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2567
# text = Inhibition of TF induction in the presence of high CsA blood concentrations was also observed when stimulation of cells was performed with interferon-gamma or interleukin-1beta.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
10	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2568
# text = As shown by reverse transcription-polymerase chain reaction and electrophoretic mobility shift assay, respectively, treatment with CsA leads to decreased TF mRNA expression and reduced activation of the NF-kappaB transcription factor, which is known to contribute to the induction of the TF promotor in human monocytes.
1	As	as	SCONJ	IN	_	_	_	_	_
2	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
21	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	decreased	decreased	VERB	VB	VerbForm=Inf	_	_	_	_
24	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
49	promotor	promotor	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
52	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2569
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2570
# text = This study demonstrates that TF activation, occurring in mononuclear cells of cardiac transplant recipients, is inhibited by treatment with CsA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TF	Tf	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
14	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
15	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2571
# text = Inhibition of monocyte TF induction by CsA may contribute to its successful use in cardiac transplant medicine and might be useful in managing further settings of vascular pathology also known to involve TF expression and NF-kappaB activation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	successful	successful	ADJ	JJ	Degree=Pos	_	_	_	_
13	use	use	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
16	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
17	medicine	medicine	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	managing	manag	VERB	VBG	VerbForm=Ger	_	_	_	_
24	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
25	settings	setting	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
28	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	_
29	also	also	ADV	RB	_	_	_	_	_
30	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	involve	involve	ADJ	JJ	Degree=Pos	_	_	_	_
33	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
34	expression	expression	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2572
# text = Document 003001150 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001150	003001150	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2573
# text = Activation of transcription factor NF-kappa B by phagocytic stimuli in human neutrophils.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2574
# text = Phagocytosis represents an important physiological trigger for the inducible expression of several genes in human neutrophils.
1	Phagocytosis	Phagocytosis	PROPN	NNP	Number=Sing	_	_	_	_
2	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2575
# text = Here, we report that a DNA-binding activity primarily consisting of the classical NF-kappa B heterodimer, p50/RelA, is induced in phagocytosing neutrophils.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	primarily	primarily	ADV	RB	_	_	_	_	_
12	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	phagocytosing	phagocytose	VERB	VBG	VerbForm=Ger	_	_	_	_
30	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2576
# text = Under these conditions, NF-kappa B activation was found to be a rapid and transient response, reaching a maximum by 10-15 min, and returning to near-basal levels by 30 min.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	15	15	NUM	CD	NumType=Card	_	_	_	_
27	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	returning	return	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	near	near	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	30	30	NUM	CD	NumType=Card	_	_	_	_
38	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2577
# text = In neutrophils undergoing the phagocytosis of opsonized yeasts, the onset of NF-kappa B activation was paralleled by a decline in immunoreactive I kappa B-alpha protein levels, and the cellular
1	In	in	ADP	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	opsonized	opsonized	ADJ	JJ	Degree=Pos	_	_	_	_
8	yeasts	yeast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	X	GW	_	_	_	_	_
27	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
28	alpha	alpha	X	GW	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2578
# text = I kappa B-alpha pool was replenished by 30 min, in agreement with our gel shift data.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	GW	_	_	_	_	_
3	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	GW	_	_	_	_	_
5	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	replenished	replenish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	30	30	NUM	CD	NumType=Card	_	_	_	_
10	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
16	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
17	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
18	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2579
# text = We conclude that NF-kappa B activation could constitute one of the mechanisms whereby the expression of kappa B-responsive genes is enhanced in phagocytosing neutrophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	whereby	whereby	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	phagocytosing	phagocytose	VERB	VBG	VerbForm=Ger	_	_	_	_
28	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2580
# text = To our knowledge, this represents the first demonstration that phagocytic stimuli can induce NF-kappa B activation in human neutrophils.
1	To	to	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2581
# text = Document 003001151 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001151	003001151	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2582
# text = Binding of erythroid and non-erythroid nuclear proteins to the silencer of the human epsilon-globin-encoding gene.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2583
# text = To clarify the molecular mechanisms involved in the developmental control of hemoglobin-encoding genes we have been studying the expression of these genes in human cells in continuous culture.
1	To	to	PART	TO	_	_	_	_	_
2	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	studying	study	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2584
# text = We have previously reported the presence of a transcriptional control element with the properties of a silencer extending from -392 to -177 bp relative to the cap site of the human epsilon-globin-encoding gene [Cao et al.,
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
18	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	-392	-392	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	177	177	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
25	relative	relative	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	Cao	Cao	PROPN	NNP	Number=Sing	_	_	_	_
41	et	et	X	FW	_	_	_	_	_
42	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 2585
# text = Proc.Natl.Acad.Sci.USA 86 (1989) 5306-5309].
1	Proc.Natl.Acad.Sci.USA	Proc.Natl.Acad.Sci.USA	PROPN	NNP	Number=Sing	_	_	_	_
2	86	86	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	1989	1989	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	5306	5306	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5309	5309	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2586
# text = We also showed that this silencer has stronger inhibitory activity in HeLa cells, as compared to K562 human erythroleukemia cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
9	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	K562	K562	NUM	CD	NumType=Card	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2587
# text = Using deletion mutants and cis-cloned synthetic oligodeoxyribonucleotides in transient expression assays, nucleotide sequences responsible for this effect have now been further delimited to 44 bp located from -294 to -251 bp.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
9	oligodeoxyribonucleotides	oligodeoxyribonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	now	now	ADV	RB	_	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	further	further	ADV	RB	_	_	_	_	_
25	delimited	delimit	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	44	44	NUM	CD	NumType=Card	_	_	_	_
28	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
29	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	294	294	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	251	251	NUM	CD	NumType=Card	_	_	_	_
36	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2588
# text = Gel electrophoresis mobility shift assays and DNaseI footprinting assays demonstrate that these negative regulatory sequences are recognized differently by proteins present in nuclear extracts obtained from HeLa and K562 cells.
1	Gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	electrophoresis	electrophoresis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	DNaseI	DNaseI	NOUN	NNS	Number=Plur	_	_	_	_
8	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
9	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	differently	differently	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
25	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	K562	K562	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2589
# text = Two binding proteins are detected in K562 nuclear extracts, while only one is found in extracts from HeLa cells.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	K562	K562	NUM	CD	NumType=Card	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	while	while	SCONJ	IN	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2590
# text = Possible mechanisms by which these proteins may regulate transcription of the epsilon-globin-encoding gene in erythroid and non-erythroid cells are discussed.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	globin-encoding	globin-encoding	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2591
# text = Document 003001152 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001152	003001152	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2592
# text = A novel SP-1 site in the human interleukin-1 beta promoter confers preferential transcriptional activity in keratinocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
16	preferential	preferential	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2593
# text = To investigate the mechanisms of transcriptional activation of interleukin-1beta (IL-1beta) in non-monocytic cells, we constructed a series of reporter plasmids with the bacterial chloramphenicol acetyltransferase gene linked to various parts of the human IL-1beta promoter and performed transient transfection experiments.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	non-monocytic	non-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	constructed	construct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	series	series	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
32	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
33	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
38	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
50	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
51	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2594
# text = We identified a promoter segment that activates transcription most efficiently in keratinocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	most	most	ADV	RBS	_	_	_	_	_
10	efficiently	efficiently	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2595
# text = Electrophoretic mobility shift assays (EMSA) with a 43-mer oligonucleotide derived from the functionally identified cis-acting element revealed specific complexes.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	43	43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mer	mer	NOUN	NN	Number=Sing	_	_	_	_
13	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	functionally	functionally	ADV	RB	_	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cis-acting	cis-act	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2596
# text = By competition analysis with transcription factor consensus sequence oligonucleotides and by immunosupershift, transcription factor SP-1 or a closely related protein was shown to bind to this regulatory element.
1	By	by	ADP	IN	_	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	immunosupershift	immunosupershift	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	closely	closely	ADV	RB	_	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2597
# text = The closest match to the known SP-1 consensus sequence within the respective region is a TCCCCTCCCCT motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	closest	closest	ADJ	JJS	Degree=Sup	_	_	_	_
3	match	match	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	TCCCCTCCCCT	Tcccctcccct	NOUN	NN	Number=Sing	_	_	_	_
19	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2598
# text = Mutation of this motif almost completely, and specifically, abolished the binding of two low-mobility complexes and led to a 95% decrease of constitutive transcriptional activation of a reporter construct IL-1beta (-170/+108).
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	completely	completely	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	specifically	specifically	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	_
26	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
35	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
39	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
40	170	170	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	/+	/+	SYM	SYM	_	_	_	_	SpaceAfter=No
42	108	108	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2599
# text = Likewise, activation of this reporter construct by tumor necrosis factor-alpha depended on the SP-1 site.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	depended	depend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2600
# text = These observations suggest that a so-far-unrecognized SP-1 site in the human IL-1beta promoter may participate in the transcriptional regulation of this gene in keratinocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	far-	far-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
10	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	bet	bet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2601
# text = Document 003001153 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001153	003001153	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2602
# text = Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.
1	Multifactor	Multifactor	NOUN	NN	Number=Sing	_	_	_	_
2	cis	cis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-dominant	-dominant	ADJ	JJ	Degree=Pos	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	anergized	anergized	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2603
# text = The molecular mechanism underlying IL-2 transcriptional blockade in anergic T cell clones is not fully understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	fully	fully	ADV	RB	_	_	_	_	_
18	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2604
# text = To examine whether an active negative regulatory process occurs, we created a reporter construct containing as an enhancer four copies of the NF-AT site and one copy of the octamer site (4X NF-AT-Oct).
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	process	process	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	created	create	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	four	four	NUM	CD	NumType=Card	_	_	_	_
21	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	one	one	NUM	CD	NumType=Card	_	_	_	_
30	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	octamer	octamer	ADJ	JJR	Degree=Cmp	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	4X	4X	PROPN	NNP	Number=Sing	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2605
# text = This construct was only slightly reduced (1.3-fold) in its expression when stimulated under anergic conditions, while a whole mouse IL-2 enhancer construct showed a reduction of 4.3-fold.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	slightly	slightly	ADV	RB	_	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1.3	1.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
19	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	while	while	SCONJ	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	4.3	4.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2606
# text = Addition of the -176 to -96 sequence to the 4X NF-AT-Oct construct did not impart the ability to be affected by anergy, but addition of the -236 to -96 sequence did, demonstrating that anergy is an active inhibitory process and that more than the presence of the -150 AP-1 binding site (-152 to -147) is required to mediate the effect.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	176	176	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	96	96	NUM	CD	NumType=Card	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	4X	4X	PROPN	NNP	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
18	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	impart	impart	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	236	236	NUM	CD	NumType=Card	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	96	96	NUM	CD	NumType=Card	_	_	_	_
39	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
40	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
43	that	that	SCONJ	IN	_	_	_	_	_
44	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
49	process	process	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	that	that	SCONJ	IN	_	_	_	_	_
52	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
53	than	than	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
59	150	150	NUM	CD	NumType=Card	_	_	_	_
60	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
64	site	site	NOUN	NN	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
67	152	152	NUM	CD	NumType=Card	_	_	_	_
68	to	to	ADP	IN	_	_	_	_	_
69	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
70	147	147	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
71	)	)	PUNCT	-RRB-	_	_	_	_	_
72	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
73	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
74	to	to	PART	TO	_	_	_	_	_
75	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2607
# text = Mutational studies of the -236 to -96 sequence indicated that the presence of both the -130 AP-1-like site (-187 to -181) and the -150 proximal AP-1 site were necessary to observe anergy.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	236	236	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	96	96	NUM	CD	NumType=Card	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	130	130	NUM	CD	NumType=Card	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	187	187	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	181	181	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	150	150	NUM	CD	NumType=Card	_	_	_	_
37	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	_
42	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	observe	observe	VERB	VB	VerbForm=Inf	_	_	_	_
46	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2608
# text = Because the -180 site is not required for trans-activation, it was possible to confirm by mutation in the normal mouse IL-2 enhancer that this site is absolutely essential for anergy induction.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	180	180	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	absolutely	absolutely	ADV	RB	_	_	_	_	_
33	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2609
# text = The simplest model to explain these results is that anergy is mediated by a complex of multiple transcription factors that exert a cis-acting dominant negative regulatory effect on the trans-activation of the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	simplest	simplest	ADJ	JJS	Degree=Sup	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	anergy	anergy	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
26	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2610
# text = Document 003001154 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001154	003001154	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2611
# text = Disruption of alpha beta but not of gamma delta
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	delta	delta	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2612
# text = T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	development	development	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	committed	committed	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2613
# text = Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC).
1	Enforced	Enforced	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Id3	Id3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
13	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
14	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
30	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	undergone	undergone	ADJ	JJ	Degree=Pos	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
44	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
45	development	development	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	transduced	transduced	ADJ	JJ	Degree=Pos	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	into	into	ADP	IN	_	_	_	_	_
51	TCRalpha	TCRalpha	PROPN	NNP	Number=Sing	_	_	_	_
52	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
55	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
60	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
61	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
62	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2614
# text = Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	document	document	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Id3	Id3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	TCR	Tcr	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
23	development	development	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	TCRalpha	TCRalpha	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	TCRgamma	TCRgamma	PROPN	NNP	Number=Sing	_	_	_	_
31	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2615
# text = Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
4	impedes	impede	NOUN	NNS	Number=Plur	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
8	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	downregulates	downregulate	NOUN	NNS	Number=Plur	_	_	_	_
12	pre-Talpha	pre-Talpha	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2616
# text = These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	DET	WDT	PronType=Int	_	_	_	_
8	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
9	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	differentially	differentially	ADV	RB	_	_	_	_	_
12	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	TCRalpha	TCRalpha	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
22	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2617
# text = We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
10	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
13	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(-)	(-)	PUNCT	.	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	Id3	Id3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2618
# text = These cells had properties of both natural killer (NK) and pre-T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
8	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2619
# text = These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	bHLH	bhlh	DET	DT	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T/	t/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
18	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
19	checkpoint	checkpoint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2620
# text = Document 003001155 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001155	003001155	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2621
# text = Human CD3-CD16+ natural killer cells express the hGATA-3 T cell transcription factor and an unrearranged 2.3-kb TcR delta transcript.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	CD3-CD	Cd3-cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
6	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-3	-3	NUM	CD	NumType=Card	_	_	_	_
12	T	t	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
19	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
22	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
23	delta	delta	ADP	IN	Abbr=Yes	_	_	_	_
24	transcript	transcriep	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2622
# text = In this study we analyzed the T cell receptor(TcR) delta transcripts expressed by CD3-CD16+ cells and we investigated whether these cells expressed the hGATA-3 T cell transcription factor and the recombination-activating gene (RAG)-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
14	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	CD3-CD	Cd3-cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	whether	whether	SCONJ	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	hGATA	hGATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-3	-3	NUM	CD	NumType=Card	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2623
# text = Multiple TcR delta transcripts deriving from an unrearranged TcR delta gene were detected in both polyclonal and clonal CD3-CD16+ natural killer(NK) cell lines.
1	Multiple	multiple	PROPN	NNP	Number=Sing	_	_	_	_
2	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
3	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
4	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
5	deriving	derive	VERB	VBG	VerbForm=Ger	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
9	TcR	Tcr	PROPN	NNP	Number=Sing	_	_	_	_
10	delta	delof	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD3-	Cd3-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
24	killer	killer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2624
# text = Two unrearranged TcR delta transcripts had a size similar to that of the functional TcR delta mRNA (2.3 and 1.3 kb) found in TcR gamma/delta+
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	unrearranged	unrearrang	ADJ	JJ	Degree=Pos	_	_	_	_
3	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
4	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	size	size	NOUN	NN	Number=Sing	_	_	_	_
9	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
16	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	2.3	2.3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	1.3	1.3	NUM	CD	NumType=Card	_	_	_	_
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
27	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 2625
# text = T lymphocytes.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2626
# text = Sequence analysis of nine different 2.3-kb cDNA clones obtained from NK-derived polyA+
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nine	nine	NUM	CD	NumType=Card	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
9	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
10	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
11	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	polyA	polya	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_

# sent_id = 2627
# text = RNA confirmed that they corresponded to an unrearranged TcR delta gene.
1	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
2	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	corresponded	correspond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
9	TcR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
10	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2628
# text = These cDNA were 2343 bp long and their transcription initiation site was located 814 bp upstream from the J delta 1 segment.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	2343	2343	NUM	CD	NumType=Card	_	_	_	_
5	bp	bp	ADV	RB	_	_	_	_	_
6	long	long	ADV	RB	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	814	814	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	J	j	PROPN	NNP	Number=Sing	_	_	_	_
20	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	segment	segment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2629
# text = The sequence located upstream of the J delta 1 segment corresponded to the previously reported germ-line sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	J	j	PROPN	NNP	Number=Sing	_	_	_	_
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
11	corresponded	correspond	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	previously	previously	ADV	RB	_	_	_	_	_
15	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	germ	germ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2630
# text = The J delta 1 segment was correctly spliced to C delta; in addition the four C delta exons were found to be already assembled.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	J	j	PROPN	NNP	Number=Sing	_	_	_	_
3	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	correctly	correctly	ADV	RB	_	_	_	_	_
8	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	four	four	NUM	CD	NumType=Card	_	_	_	_
17	C	C	NOUN	NN	Number=Sing	_	_	_	_
18	delta	delta	PART	TO	Abbr=Yes	_	_	_	_
19	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	already	already	ADV	RB	_	_	_	_	_
25	assembled	assemble	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2631
# text = Two polyadenylation sites were present in the fourth C delta exon.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	fourth	fourth	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	_
10	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
11	exon	exon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2632
# text = However, only that located at the 3' end appeared to be utilized in the 2.3-kb cDNA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PART	POS	_	_	_	_	_
10	end	end	NOUN	NN	Number=Sing	_	_	_	_
11	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
20	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2633
# text = The expression of hGATA-3, a T cell-specific factor known to be involved in the regulation of the transcription of TcR delta locus, was analyzed by Northern blot, in cultured NK cell population and clones (but not in freshly derived cell populations).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hGATA	hGATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
26	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
27	locus	locus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	Northern	northern	PROPN	NNP	Number=Sing	_	_	_	_
33	blot	blot	ADV	RB	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	population	population	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	but	but	CCONJ	CC	_	_	_	_	_
44	not	not	PART	RB	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	freshly	freshly	ADV	RB	_	_	_	_	_
47	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2634
# text = All NK clones and cell lines studied were found to express hGATA-3-specific mRNA, suggesting that hGATA-3 may be involved in the regulation of the unrearranged TcR delta gene expression in NK cells.
1	All	all	DET	DT	_	_	_	_	_
2	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
12	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	hGATA	hGATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
33	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
34	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2635
# text = Finally, no transcription of the RAG-1 gene could be detected in all NK cell lines or clones analyzed.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
21	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2636
# text = Document 003001156 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001156	003001156	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2637
# text = NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.
1	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	CAML	caml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	interacting	interacting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2638
# text = Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
20	event	event	NOUN	NN	Number=Sing	_	_	_	_
21	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
23	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2639
# text = The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CAML	caml	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	coinducer	coinducer	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2640
# text = A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	member	member	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	superfamily	superfamily	ADV	RB	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2641
# text = Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	TACI	Taci	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CAML	caml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	TACI	TACI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
34	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2642
# text = TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate.
1	TACI	Taci	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
17	CAML	caml	NOUN	NN	Number=Sing	_	_	_	_
18	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	CAML	CAML	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2643
# text = Document 003001157 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001157	003001157	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2644
# text = Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2645
# text = We have examined the effects of N-acetyl-L-cysteine (NAC), a well-characterized, thiol-containing antioxidant, on agonist-induced monocytic cell adhesion to endothelial cells (EC).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-L	-l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
24	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2646
# text = NAC inhibited interleukin-1 (IL-1 beta)-induced, but not basal, adhesion with 50% inhibition at approximately 20 mM.
1	NAC	NAC	X	LS	_	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	approximately	approximately	ADV	RB	_	_	_	_	_
26	20	20	NUM	CD	NumType=Card	_	_	_	_
27	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2647
# text = Monocytic cell adhesion to EC in response to tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), alpha-thrombin, or phorbol 12-myristate 13-acetate (PMA) was similarly inhibited by NAC.
1	Monocytic	Monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
26	-thrombin	-thrombin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
30	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
32	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
33	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	similarly	similarly	ADV	RB	_	_	_	_	_
41	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2648
# text = Unlike published studies with pyrrolidinedithiocarbamate, which specifically inhibited vascular cell adhesion molecule 1 (VCAM-1), NAC inhibited IL-1 beta-induced mRNA and cell surface expression of both E-selectin and VCAM-1.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2649
# text = NAC had no effect on the half-life of E-selectin or VCAM-1 mRNA.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	life	life	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2650
# text = Although NAC reduced nuclear factor-kappa B (NF-kappa B) activation in EC as measured by gel-shift assays using an oligonucleotide probe corresponding to the consensus NF-kappa B binding sites of the VCAM-1 gene (VCAM-NF-kappa B), the antioxidant had no appreciable effect when an oligomer corresponding to the consensus NF-kappa B binding site of the E-selectin gene (E-selectin-NF-kappa B) was used.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
3	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
24	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
28	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
29	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
38	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
56	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	no	no	DET	DT	_	_	_	_	_
58	appreciable	appreciable	ADJ	JJ	Degree=Pos	_	_	_	_
59	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
60	when	when	ADV	WRB	PronType=Int	_	_	_	_
61	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
63	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
64	to	to	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
67	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
70	B	b	NOUN	NN	Number=Sing	_	_	_	_
71	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
72	site	site	NOUN	NN	Number=Sing	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
75	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
77	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
78	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
79	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
82	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
84	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
85	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
86	)	)	PUNCT	-RRB-	_	_	_	_	_
87	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
88	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
89	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2651
# text = Because NF-kappa
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2652
# text = B has been reported to be redox sensitive, we studied the effects of NAC on the EC redox environment.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	redox	redox	ADV	RB	_	_	_	_	_
8	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
19	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
20	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2653
# text = NAC caused an expected dramatic increase in the reduced glutathione (GSH) levels in EC.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	GSH	GSH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2654
# text = In vitro studies demonstrated that whereas the binding affinity of NF-kappa B to the VCAM-NF-kappa B oligomer peaked at a GSH-to-oxidized glutathione (GSSG) ratio of approximately 200 and decreased at higher ratios, the binding to the E-selectin-NF-kappa B oligomer appeared relatively unaffected even at ratios > 400, i.e., those achieved in EC treated with 40 mM NAC.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	whereas	whereas	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
24	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	approximately	approximately	ADV	RB	_	_	_	_	_
39	200	200	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	at	at	ADP	IN	_	_	_	_	_
43	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
44	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
55	B	b	PROPN	NNP	Number=Sing	_	_	_	_
56	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
57	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
58	relatively	relatively	ADV	RB	_	_	_	_	_
59	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
60	even	even	ADV	RB	_	_	_	_	_
61	at	at	ADP	IN	_	_	_	_	_
62	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	_
63	>	>	PUNCT	,	_	_	_	_	_
64	400	400	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
69	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
70	in	in	ADP	IN	_	_	_	_	_
71	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
72	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
73	with	with	ADP	IN	_	_	_	_	_
74	40	40	NUM	CD	NumType=Card	_	_	_	_
75	mM	mm	PROPN	NNP	Number=Sing	_	_	_	_
76	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2655
# text = These results suggest that NF-kappa B binding to its consensus sequences in the VCAM-1 and E-selectin gene exhibits marked differences in redox sensitivity, allowing for differential gene expression regulated by the same transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	exhibits	exhibit	NOUN	NNS	Number=Plur	_	_	_	_
24	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
28	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2656
# text = Our data also demonstrate that NAC increases the GSH-to-GSSG ratio within the EC suggesting one possible mechanism through which this antioxidant inhibits agonist-induced monocyte adhesion to EC.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
7	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	_
14	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
18	suggesting	suggest	NOUN	NN	Number=Sing	_	_	_	_
19	one	one	NUM	CD	NumType=Card	_	_	_	_
20	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
26	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2657
# text = Document 003001158 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001158	003001158	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2658
# text = Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
1	Dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2659
# text = Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
5	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2660
# text = This study tested the hypothesis that anti-LPS
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	anti-LPS	anti-LPS	X	ADD	_	_	_	_	_

# sent_id = 2661
# text = Abs neutralize endotoxin by blocking cellular uptake through mCD14.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
2	neutralize	neutralize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	endotoxin	endotoxin	ADV	RB	_	_	_	_	_
4	by	by	SCONJ	IN	_	_	_	_	_
5	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	mCD	mCD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2662
# text = Ab-associated changes in the uptake and cellular distribution of FITC-LPS were assessed by flow cytometry and laser scanning confocal microscopy in human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes.
1	Ab-	Ab-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	FITC	FITC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
18	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	laser	laser	NOUN	NN	Number=Sing	_	_	_	_
21	scanning	scan	VERB	VBG	VerbForm=Ger	_	_	_	_
22	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
23	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-transfected	-transfect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
29	hamster	hamster	NOUN	NN	Number=Sing	_	_	_	_
30	ovary	ovary	ADJ	JJ	Degree=Pos	_	_	_	_
31	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	14	14	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
42	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2663
# text = LPS core- and O-side chain-specific mAbs inhibited mCD14-mediated LPS uptake by both cell types in the presence of serum.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	O-	O-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	side	side	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	mCD14	mcd14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-mediated	-mediate	ADJ	JJ	Degree=Pos	_	_	_	_
14	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
15	uptake	uptake	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	types	type	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2664
# text = O-side chain-specific mAb concurrently enhanced complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s).
1	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	side	side	NOUN	NN	Number=Sing	_	_	_	_
4	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	concurrently	concurrently	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	complement	complement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
14	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CR1	Cr1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	14	14	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
34	another	another	DET	DT	_	_	_	_	_
35	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
38	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	s	s	X	AFX	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
48	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	s	s	X	AFX	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2665
# text = Core-specific mAb inhibited mCD14-mediated uptake of homologous and heterologous LPS, while producing less concurrent enhancement of non-mCD14-mediated LPS uptake.
1	Core-	Core-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
4	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
18	concurrent	concurrent	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	non-mCD14	non-mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
23	LPS	Lp	NOUN	NN	Number=Sing	_	_	_	_
24	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2666
# text = The modulation by anti-LPS mAbs of mCD14-mediated LPS uptake was associated with inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively, while mAb enhancement of non-mCD14-mediated LPS uptake stimulated these activities.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	anti-LPS	anti-LPS	ADJ	JJ	Degree=Pos	_	_	_	_
5	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
10	uptake	uptake	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	14	14	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	while	while	SCONJ	IN	_	_	_	_	_
46	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
47	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	non-mCD14	non-mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
51	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
52	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
53	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
55	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2667
# text = LPS-specific
1	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2668
# text = Abs thus mediate anti-inflammatory and proinflammatory functions, respectively, by preventing target cell uptake of LPS through mCD14 and augmenting uptake through CR1 or other cell receptors.
1	Abs	Ab	ADV	RB	_	_	_	_	_
2	thus	thus	ADV	RB	_	_	_	_	_
3	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
13	target	target	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
22	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	CR1	Cr1	PROPN	NNP	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2669
# text = Document 003001159 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001159	003001159	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2670
# text = Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	hydrocortisone	hydrocortisone	ADJ	JJ	Degree=Pos	_	_	_	_
16	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2671
# text = We have recently demonstrated that hydrocortisone and other glucocorticoids inhibit reactive oxygen species (ROS) generation by mononuclear (MNC) and polymorphonuclear leucocytes (PMNL).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
10	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
13	species	species	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ROS	ROS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PMNL	PMNL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2672
# text = Since NF-kappaB/IkappaB system regulates the transcription of proinflammatory genes, including those responsible for ROS generation, we tested the hypothesis that hydrocortisone may stimulate IkappaB production thus inhibiting NF-kappaB translocation from the cytosol into the nucleus in MNC, in vivo.
1	Since	since	ADP	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	_
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	_
20	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	hydrocortisone	hydrocortisone	PRON	NN	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
30	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	thus	thus	ADV	RB	_	_	_	_	_
33	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
41	into	into	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2673
# text = One hundred milligram of hydrocortisone was injected intravenously into 4 normal subjects.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	hundred	hundred	NUM	CD	NumType=Card	_	_	_	_
3	milligram	milligram	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	injected	inject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	intravenously	intravenously	ADV	RB	_	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2674
# text = Blood samples were obtained prior to the injection and at 1, 2, 4, 8 and 24 hr after the injection.
1	Blood	Blood	ADJ	JJ	Degree=Pos	_	_	_	_
2	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	injection	injection	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2675
# text = Nuclear extracts and total cell lysates were prepared from MNC by standard techniques.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
13	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2676
# text = IkappaB
1	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2677
# text = levels in MNC homogenates increased at 1 hr, peaked at 2-4 hr, started to decrease at 8 hr, and returned to baseline levels at 24 hr.
1	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
4	homogenates	homogenate	NOUN	NNS	Number=Plur	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	started	start	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	8	8	NUM	CD	NumType=Card	_	_	_	_
22	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	returned	return	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	24	24	NUM	CD	NumType=Card	_	_	_	_
31	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2678
# text = NF-kappaB in MNC nuclear extracts decreased at 1 hr, reached a nadir at 4 hr, gradually increased at 8 hr and returned back to baseline levels at 24 hr.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	nadir	nadir	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	gradually	gradually	ADV	RB	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	8	8	NUM	CD	NumType=Card	_	_	_	_
24	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	returned	return	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	back	back	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	24	24	NUM	CD	NumType=Card	_	_	_	_
33	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2679
# text = The total protein content of NF-kappaB subunit (P65) in MNC lysates also showed a decrease following hydrocortisone injection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	content	content	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	P65	P65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
15	lysates	lysates	PROPN	NNP	Number=Sing	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	hydrocortisone	hydrocortisone	ADJ	JJ	Degree=Pos	_	_	_	_
22	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2680
# text = This decrease was observed at 2 hr, reached a nadir at 4 hr, and returned to baseline levels at 24 hr.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	nadir	nadir	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	returned	return	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	baseline	baseline	VERB	VB	VerbForm=Inf	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	24	24	NUM	CD	NumType=Card	_	_	_	_
23	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2681
# text = ROS generation inhibition paralleled NF-kappaB levels in the nucleus.
1	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2682
# text = It was inhibited at 1 hr, reached a nadir at 2-4 hr, started to increase at 8 hr, and returned to basal levels at 24 hr.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	nadir	nadir	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	started	start	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	8	8	NUM	CD	NumType=Card	_	_	_	_
22	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	returned	return	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	24	24	NUM	CD	NumType=Card	_	_	_	_
31	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2683
# text = Our data demonstrate that hydrocortisone induces IkappaB and suppresses NF-kappaB expression in MNC in parallel.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	hydrocortisone	hydrocortisone	PRON	NN	Number=Sing	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2684
# text = IkappaB further reduces the translocation of NF-kappaB into the nucleus thus preventing the expression of proinflammatory genes.
1	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
13	thus	thus	ADV	RB	_	_	_	_	_
14	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2685
# text = Document 003001160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001160	003001160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2686
# text = Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes.
1	Anaphylatoxins	Anaphylatoxins	PROPN	NNP	Number=Sing	_	_	_	_
2	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2687
# text = The anaphylatoxins C5a and C3a are involved in the regulation of cytokine production.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	anaphylatoxins	anaphylatoxin	NOUN	NNS	Number=Plur	_	_	_	_
3	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	a	a	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2688
# text = In this study the capability of C5a and C3a to induce transcription factor activation was examined.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	capability	capability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2689
# text = C5a and C3a stimulation of human peripheral blood monocytes resulted in nuclear expression of a DNA binding activity with specificity to the kappaB sequence.
1	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2690
# text = The p50 and p65 proteins, constituents of the prototypic nuclear factor kappaB, were identified as components of the DNA-protein complexes by anti-peptide antibodies in gel supershift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	constituents	constituent	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	prototypic	prototypic	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	components	component	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	anti-peptide	anti-peptide	ADJ	JJ	Degree=Pos	_	_	_	_
27	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
30	supershift	supershift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2691
# text = C5a induced kappaB binding activity was detected 15 min after agonist stimulation, peaked at 30-40 min, and remained detectable at 2 h.
1	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	15	15	NUM	CD	NumType=Card	_	_	_	_
10	min	min	NOUN	NNS	Number=Plur	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	40	40	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2692
# text = Binding to kappaB sequence was accompanied by an initial decrease and subsequent increase in the cytoplasmic IkappaBalpha levels, as detected by Western blotting using an anti-IkappaBalpha antibody.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
10	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	as	as	SCONJ	IN	_	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
24	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	anti-IkappaBalpha	anti-IkappaBalpha	ADJ	JJ	Degree=Pos	_	_	_	_
28	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2693
# text = Pertussis toxin treatment markedly decreased kappaB binding activities induced by both C5a and C3a, whereas cholera toxin displayed no inhibitory effect.
1	Pertussis	Pertussis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	markedly	markedly	ADV	RB	_	_	_	_	_
5	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
19	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
20	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2694
# text = Neither of the two toxins affected kappaB binding activity induced by TNFalpha in the same cells.
1	Neither	neither	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	toxins	toxin	NOUN	NNS	Number=Plur	_	_	_	_
6	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2695
# text = These results imply a potential role of the anaphylatoxins C5a and C3a in regulating leukocytes gene expression through G protein-coupled transcription factor activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	anaphylatoxins	anaphylatoxins	PROPN	NNPS	Number=Plur	_	_	_	_
10	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	in	in	NOUN	NN	Number=Sing	_	_	_	_
16	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	G	G	PROPN	NNP	Number=Sing	_	_	_	_
22	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2696
# text = Document 003001161 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001161	003001161	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2697
# text = Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	heparin	heparin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
13	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2698
# text = Correlation with an increased kappa B binding activity.
1	Correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2699
# text = Human peripheral blood monocytes responded to stimulation of platelet-activating factor (PAF) with up-regulation of the transcript for heparin-binding epidermal growth factor-like growth factor (HB-EGF), a potent mitogen for vascular smooth muscle cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	responded	respond	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	heparin-	heparin-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
41	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
44	smooth	smooth	ADJ	JJ	Degree=Pos	_	_	_	_
45	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2700
# text = This function of PAF was observed at nanomolar concentrations of the ligand, starting at 30 min after stimulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	nanomolar	nanomolar	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	30	30	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2701
# text = The PAF-induced up-regulation of HB-EGF mRNA was accompanied by an increase in kappa B binding activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2702
# text = These functions of PAF appeared to be mediated through the cell surface PAF receptors, as two PAF receptor antagonists, WEB 2086 and L-659,989, blocked both the up-regulation of HB-EGF mRNA and kappa B binding activity induced by PAF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
5	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
13	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	WEB	Web	PROPN	NNP	Number=Sing	_	_	_	_
23	2086	2086	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	L-659,989	L-659,989	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	both	both	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
37	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2703
# text = The antagonists, however, had no effect on phorbol ester-induced up-regulation of HB-EGF mRNA and kappa B binding activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
21	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2704
# text = Pretreatment of monocytes with pertussis toxin inhibited these functions of PAF, whereas cholera toxin had no inhibitory effect.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	pertussis	pertussis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
15	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
16	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2705
# text = Pyrrolidine dithiocarbamate, an inhibitor for NF-kappa B activation, markedly reduced PAF-stimulated kappa B binding activity as well as up-regulation of HB-EGF mRNA.
1	Pyrrolidine	Pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
2	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	markedly	markedly	ADV	RB	_	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
32	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2706
# text = These results suggest a potential role of PAF in HB-EGF expression and provide evidence that this stimulation may occur through increased kappa B binding activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2707
# text = Document 003001162 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001162	003001162	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2708
# text = Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Runt	Runt	PROPN	NNP	Number=Sing	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
16	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2709
# text = The PEBP2 alpha
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2710
# text = A and PEBP2 alpha B genes encode the DNA-binding subunit of a murine transcription factor, PEBP2, which is implicated as a T-cell-specific transcriptional regulator.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2711
# text = These two related genes share the evolutionarily conserved region encoding the Runt domain.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	evolutionarily	evolutionarily	ADV	RB	_	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Runt	Runt	PROPN	NNP	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2712
# text = PEBP2 alpha
1	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2713
# text = B is the murine counterpart of human AML1, which is located at the breakpoints of the 8;21 and 3;21 chromosome translocations associated with acute myeloid leukemia.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
5	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	8;21	8;21	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
22	21	21	NUM	CD	NumType=Card	_	_	_	_
23	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
24	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
25	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
28	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2714
# text = Northern (RNA) blots of various adult mouse tissues revealed that the levels of expression of both genes were most prominent in the thymus.
1	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
8	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2715
# text = Furthermore, transcripts of PEBP2 alpha
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2716
# text = A and mouse AML1/PEBP2 alpha
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2717
# text = B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns, as well as 4-week-old adult mice, by in situ hybridization.
1	B	benefit	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	thymuses	thymuse	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	day	day	NOUN	NN	Number=Sing	_	_	_	_
12	16	16	NUM	CD	NumType=Card	_	_	_	_
13	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	newborns	newborn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	ADV	RB	_	_	_	_	_
18	well	well	ADV	RB	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	week	week	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	old	old	ADJ	JJ	Degree=Pos	_	_	_	_
25	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
31	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2718
# text = The expression of the genes persisted in peripheral lymph nodes of adult mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	persisted	persist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
10	nodes	node	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
13	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2719
# text = The transcripts were detected in all the CD4- CD8-, CD4+ CD8+, CD4+ CD8-, and CD4- CD8+ cell populations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	PDT	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	CD8-,	Cd8-,	NOUN	NN	Number=Sing	_	_	_	_
11	CD4+	Cd4+	NOUN	NN	Number=Sing	_	_	_	_
12	CD8+	Cd8+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD4+	CD4+	CCONJ	CC	_	_	_	_	_
15	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-,	-,	PUNCT	.	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	_
20	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2720
# text = The results indicated that both genes are expressed in T cells throughout their development, supporting the notion that PEBP2 is a T-cell-specific transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	throughout	throughout	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2721
# text = Transcripts of mouse AML1/PEBP2 alpha B were also detected in day 12 fetal hematopoietic liver and in the bone marrow cells of newborn mice.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	AML1	AML1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	day	day	NOUN	NN	Number=Sing	_	_	_	_
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
22	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	newborn	newborn	ADJ	JJ	Degree=Pos	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2722
# text = The implication of mouse AML1/PEBP2 alpha B expression in hematopoietic cells other than those of T-cell lineage is discussed in relation to myeloid leukemogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
5	AML1	AML1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	than	than	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	myeloid	myeloid	VERB	VB	VerbForm=Inf	_	_	_	_
27	leukemogenesis	leukemogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2723
# text = Document 003001163 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001163	003001163	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2724
# text = Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	E-	E-	X	GW	_	_	_	_	SpaceAfter=No
12	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
19	A	a	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2725
# text = Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	originally	originally	ADV	RB	_	_	_	_	_
12	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	athat	athat	PRON	WDT	PronType=Rel	_	_	_	_
22	supported	support	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
36	A	A	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2726
# text = As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	PRON	WDT	PronType=Dem	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2727
# text = Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%.
1	Significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	gene	gene	PRON	NN	Number=Sing	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	NFAT	NFAT	ADV	RB	_	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	60%	60%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2728
# text = CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells.
1	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
2	similarly	similarly	ADV	RB	_	_	_	_	_
3	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	up	up	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2729
# text = CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT.
1	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	though	though	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	rather	rather	ADV	RB	_	_	_	_	_
39	than	than	ADP	IN	_	_	_	_	_
40	NFAT	NFAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2730
# text = Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	29	29	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	%	%	SYM	NN	Number=Sing	_	_	_	_
41	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	neutrophil	neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
44	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2731
# text = The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	DNasel	DNasel	PROPN	NNP	Number=Sing	_	_	_	_
19	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2732
# text = This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NFAT	Nfat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	agent	agent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2733
# text = Document 003001164 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001164	003001164	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2734
# text = Suppression of a cellular differentiation program by phorbol esters coincides with inhibition of binding of a cell-specific transcription factor (NF-E2) to an enhancer element required for expression of an erythroid-specific gene.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	program	program	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
9	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
10	coincides	coincide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2735
# text = Induction by hemin increases, while induction with 12-O-tetradecanoylphorbol-13-acetate (TPA) represses, erythroid-specific gene expression in the human cell line K562.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
4	increases	increase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	12-O-	12-o-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	represses	represse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	_
28	K562	k562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2736
# text = We analyzed the effects of hemin or TPA induction on the binding and activity of transcription factors at a regulatory element found within the transcriptional regulatory sequences of many erythroid-specific genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2737
# text = TPA induction increases the binding of ubiquitous AP-1 factors to this element.
1	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2738
# text = TPA induction inhibits the binding of the lineage limited transcription factor NF-E2 to this transcriptional control element.
1	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
9	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2739
# text = Hemin induction of K562 cells does not facilitate the binding of NF-E2 to its recognition site.
1	Hemin	Hemin	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	K562	K562	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2740
# text = Hemin induction appears to nonspecifically increase the expression of transiently transfected genes in K562 cells.
1	Hemin	Hemin	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	nonspecifically	nonspecifically	ADV	RB	_	_	_	_	_
6	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transiently	transiently	ADV	RB	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	K562	K562	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2741
# text = Beyond this nonspecific increase in gene expression, hemin induction acts to increase the activity of the lineage limited transcription factor NF-E2.
1	Beyond	beyond	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
19	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2742
# text = The divergent effects of hemin and TPA on gene expression in K562 cells are mediated, in part, by their contrasting effects on the transcription factor NF-E2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	K562	K562	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	contrasting	contrast	NOUN	NN	Number=Sing	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2743
# text = Document 003001165 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001165	003001165	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2744
# text = Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	lowered	lowered	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2745
# text = Transcription factor NF kappa B (nuclear factor kappa B) is induced in T lymphocytes from young individuals following activation with a variety of stimuli including anti-CD3, phorbol myristate acetate (PMA), and tumor necrosis factor-alpha (TNF-alpha).
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
19	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
27	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
28	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
31	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
39	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2746
# text = In contrast, activated T lymphocytes from older individuals show a significant reduction in the induction of NF kappa B in response to the same stimuli.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	older	older	ADJ	JJR	Degree=Cmp	_	_	_	_
9	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
10	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
26	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2747
# text = The age-related decline in induction of NF kappa B could not be attributed to alteration in the composition of subunits, p50 and p65 were found to be the predominant subunits of induced NF kappa B in T cells from young as well as elderly donors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
5	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	p50	p50	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p65	p65	NUM	CD	NumType=Card	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
33	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	B	PROPN	NNP	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	T	T	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	from	from	ADP	IN	_	_	_	_	_
43	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
44	as	as	ADV	RB	_	_	_	_	_
45	well	well	ADV	RB	Degree=Pos	_	_	_	_
46	as	as	ADP	IN	_	_	_	_	_
47	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
48	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2748
# text = Furthermore, similar levels of NF kappa B were found in the cytosols of unactivated T cells from both young and elderly donors suggesting that precursor levels of NF kappa B remain unaltered during aging.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytosols	cytosol	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
23	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	_
34	during	during	ADP	IN	_	_	_	_	_
35	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2749
# text = These results suggest that an age-associated decline in the induction of NF kappa B in activated T cells from elderly individuals may be attributable to altered regulation of the inhibitor, I kappa B, and may play an important role in immune dysregulation accompanying aging.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
23	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
46	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
47	accompanying	accompany	VERB	VBG	VerbForm=Ger	_	_	_	_
48	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2750
# text = Document 003001166 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001166	003001166	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2751
# text = Expression of Ah receptor (TCDD receptor) during human monocytic differentiation.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2752
# text = We have previously found a high expression of human
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2753
# text = Ah receptor (TCDD receptor) mRNA in peripheral blood cells of individuals.
1	Ah	ah	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2754
# text = In this paper, the expression of this gene in blood cells was first investigated in fractions of nucleated cells, revealing predominant expression of the Ah receptor gene in the monocyte fraction.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	first	first	ADV	RB	_	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	nucleated	nucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
23	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
33	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2755
# text = Then the expression levels of AhR mRNA in various hematopoietic cell lines were examined together with those of Arnt and P450IA1.
1	Then	then	ADV	RB	PronType=Dem	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	together	together	ADV	RB	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	P450IA1	P450ia1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2756
# text = AhR was expressed at high levels in monocytoid U937, THP1, and HEL/S cells, and at moderate levels in promyelocytic HL60 cells and erythroblastic HEL cells.
1	AhR	Ahr	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	THP1	THP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	HEL/	HEL/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
15	S	s	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	erythroblastic	erythroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
28	HEL	Hel	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2757
# text = However, it was not detected in lymphoid cells MOLT4 (T cell) and BALL1 (B cell), nor in K562 erythroblasts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	MOLT4	Molt4	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	T	t	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	BALL1	Ball1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	nor	nor	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	K562	K562	NUM	CD	NumType=Card	_	_	_	_
25	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2758
# text = Furthermore, a specific induction of AhR during monocytic differentiation was investigated in HL60 and HEL cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HEL	Hel	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2759
# text = HL60 cells were induced to differentiate toward monocytes-macrophages by incubation with phorbol ester, showing a 5- to 2-fold increase of AhR mRNA.
1	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
7	toward	toward	ADP	IN	_	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2760
# text = The incubation with transforming growth factor beta 1 and 1 alpha,25-dihydroxyvitamin D3 resulted in a 5- to 7-fold increase of AhR mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	SCONJ	IN	_	_	_	_	_
4	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-dihydroxyvitamin	-dihydroxyvitamin	ADJ	JJ	Degree=Pos	_	_	_	_
13	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
14	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
26	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2761
# text = The HEL cells also exhibited a similar elevation of AhR mRNA level, when they had differentiated toward monocyte-macrophage cells by these combined inducers, but little change in the mRNA level was observed when the cells were induced to differentiate into other cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HEL	Hel	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
8	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
16	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	toward	toward	ADP	IN	_	_	_	_	_
19	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
29	change	change	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	when	when	ADV	WRB	PronType=Int	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
43	into	into	ADP	IN	_	_	_	_	_
44	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2762
# text = Treatment of the differentiated HL60 cells with 3-methylcholanthrene, a ligand of AhR, induced the expression of the P450IA1 gene.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	methylcholanthrene	methylcholanthrene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	P450IA1	P450ia1	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2763
# text = These results indicated that expression of
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_

# sent_id = 2764
# text = AhR mRNA was significantly induced during monocytic differentiation and that the differentiated cells were responsive to xenobiotics.
1	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	differentiated	differentiated	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	xenobiotics	xenobiotic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2765
# text = Our results suggest that AhR may play an important role in the function of monocytes and also in the eventual activation of environmental carcinogens.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	environmental	environmental	ADJ	JJ	Degree=Pos	_	_	_	_
24	carcinogens	carcinogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2766
# text = Document 003001167 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001167	003001167	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2767
# text = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome.
1	Genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
2	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
3	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
4	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
8	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	dispersed	disperse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2768
# text = General transcription factors are required for accurate initiation of transcription by RNA polymerase II.
1	General	General	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	accurate	accurate	ADJ	JJ	Degree=Pos	_	_	_	_
8	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
13	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2769
# text = Human cDNAs encoding subunits of these factors have been cloned and sequenced.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2770
# text = Using fluorescence in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIE alpha, TFIIE beta, RAP30, RAP74 and the 62 kDa subunit, of TFIIH are located at the human chromosomal bands 6q26-27, 1p21-22, 3q21-24, 8p12, 13q14, 19p13.3 and 11p14-15.1, respectively.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	FISH	Fish	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	here	here	ADV	RB	PronType=Dem	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	box	box	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TBP	TBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	TFIIB	TFIIB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	TFIIE	TFIIE	PROPN	NNP	Number=Sing	_	_	_	_
30	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	TFIIE	TFIIE	PROPN	NNP	Number=Sing	_	_	_	_
33	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	RAP30	RAP30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	RAP74	RAP74	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	62	62	NUM	CD	NumType=Card	_	_	_	_
41	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
42	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	TFIIH	TFIIh	DET	DT	_	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	at	at	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
51	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
52	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
53	6q26	6q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-27	-27	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	1p21-22	1p21-22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	3q21-24	3q21-24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	8p12	8p12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	13q14	13q14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	19p13.3	19p13.3	NUM	CD	NumType=Card	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	11p14	11p14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
68	15.1	15.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2771
# text = This dispersed localization of a group of functionally related gene provides insights into the molecular mechanism of human genome evolution and their possible involvement in human diseases.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	dispersed	dispersed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	group	group	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	functionally	functionally	ADV	RB	_	_	_	_	_
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
20	evolution	evolution	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
24	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2772
# text = Document 003001168 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001168	003001168	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2773
# text = Interferon-gamma and the sexual dimorphism of autoimmunity.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	sexual	sexual	ADJ	JJ	Degree=Pos	_	_	_	_
7	dimorphism	dimorphism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2774
# text = The sexual difference in the incidence of autoimmune diseases has remained an enigma for many years.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sexual	sexual	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	incidence	incidence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
9	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	remained	remain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	enigma	enigma	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
16	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2775
# text = In the examination of the induction of autoimmunity in transgenic mice, evidence has been obtained further implicating the lymphokine interferon-gamma in the etiology of autoimmunity.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	examination	examination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	further	further	SCONJ	IN	_	_	_	_	_
18	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
21	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2776
# text = Sex steroid regulation of the production of this molecule, as well as other cytokines, may help explain the gender-specific differences in the immune system, including autoimmunity.
1	Sex	sex	NOUN	NN	Number=Sing	_	_	_	_
2	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
19	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	gender	gender	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2777
# text = Document 003001169 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001169	003001169	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2778
# text = Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.
1	Alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
2	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
10	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
11	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
16	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2779
# text = The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	p70	p70	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2780
# text = I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	607	607	NUM	CD	NumType=Card	_	_	_	_
19	amino	amino	DET	DT	_	_	_	_	_
20	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2781
# text = Here we show that alternative RNA splicing generates I kappa B gamma isoforms with properties different from those of p70.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
6	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
7	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
8	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2782
# text = One 63-kDa isoform, termed I kappa B gamma-1, which lacks 59 amino acids C-terminal to ankyrin repeat 7, has a novel 35-amino acid C terminus encoded by an alternative reading frame of the p105 gene.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	59	59	NUM	CD	NumType=Card	_	_	_	_
18	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
19	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
20	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	ankyrin	ankyrin	ADV	RB	_	_	_	_	_
24	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	_
25	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
30	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	amino	amino	DET	DT	_	_	_	_	_
33	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
34	C	c	NOUN	NN	Number=Sing	_	_	_	_
35	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
36	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
40	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
41	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2783
# text = A 55-kDa isoform, I kappa B gamma-2, lacks the 190 C-terminal amino acids of p70I kappa B gamma.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	55	55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	190	190	NUM	CD	NumType=Card	_	_	_	_
17	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	amino	amino	DET	DT	_	_	_	_	_
20	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2784
# text = In contrast to p70I kappa
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2785
# text = B gamma, which is a cytoplasmic protein, I kappa B gamma-1 is found in both the cytoplasm and nucleus, whereas I kappa B gamma-2 is predominantly nuclear.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	nucleus	nucleus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	predominantly	predominantly	ADV	RB	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2786
# text = The I kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2787
# text = B gamma isoforms also display differences in specificity and affinity for Rel/NF-kappa B proteins.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2788
# text = While p70I kappa
1	While	while	SCONJ	IN	_	_	_	_	_
2	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2789
# text = B gamma inhibits p50-, p65-, and c-Rel-mediated transactivation and/or DNA binding, both I kappa B gamma-1 and I kappa B gamma-2 are specific for p50 and have different affinities for this subunit.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-,	-,	PUNCT	.	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel-mediated	Rel-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	p50	p50	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
41	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2790
# text = The absence in I kappa B gamma-1 and I kappa B gamma-2 of a protein kinase A site whose phosphorylation modulates p70I kappa B gamma inhibitory activity suggests that alternative RNA splicing may be used to generate I kappa B gamma isoforms that respond differently to intracellular signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
26	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
29	B	b	X	GW	_	_	_	_	_
30	gamma	gamma	X	FW	Foreign=Yes	_	_	_	_
31	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
36	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
37	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
40	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
47	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
48	that	that	PRON	WDT	PronType=Rel	_	_	_	_
49	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	differently	differently	ADV	RB	_	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
53	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2791
# text = Document 003001170 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001170	003001170	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2792
# text = Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression.
1	Structure	structure	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2793
# text = The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	maturing	mature	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2794
# text = Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fixed tissues.
1	Epitope	Epitope	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	strict	strict	ADJ	JJ	Degree=Pos	_	_	_	_
9	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
20	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	paraffin-	paraffin-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	embedded	embedd	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2795
# text = A 1-kb region of the gene that includes 5' flanking sequence was reported earlier to contain functional promoter activity and was specifically demethylated in expressing cells in contrast to null cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'	'	PUNCT	``	_	_	_	_	_
13	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	specifically	specifically	ADV	RB	_	_	_	_	_
26	demethylated	demethylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	null	null	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2796
# text = Further analysis has revealed that this 1-kb fragment promotes higher reporter gene activity in MNDA-expressing cells than non-expressing cells, indicating cell-specific differences in transactivation.
1	Further	further	ADV	RB	_	_	_	_	_
2	analysis	analysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
10	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
11	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	non-expressing	non-expresse	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2797
# text = This sequence contains consensus elements consistent with myeloid-specific gene expression, including a PU.1 consensus site near the major transcription start site and a cluster of c-Myb sites located several hundred bases upstream of this region.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consensus	consensus	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
17	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	near	near	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	start	start	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	hundred	hundred	NUM	CD	NumType=Card	_	_	_	_
36	bases	base	NOUN	NNS	Number=Plur	_	_	_	_
37	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
40	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2798
# text = However, analysis of deletion mutants localized nearly all of the promoter activity to a short region (-73 to -16) that did not include the cluster of c-Myb sites.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	nearly	nearly	ADV	RB	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
19	73	73	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2799
# text = A 4-bp mutation of the core Sp1 consensus element (GC box) (-20) reduced overall promoter activity of the 1-kb fragment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
14	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
17	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
28	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2800
# text = Mutation of the PU.1 site did not significantly affect promoter activity.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2801
# text = Only a small region (-35 to +22) including the Sp1 element and transcription start site, but not the PU.1 site was footprinted.
1	Only	only	ADV	RB	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	-35	-35	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
9	22	22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	footprinted	footprint	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2802
# text = The 4-bp mutation of the core Sp1 consensus element abolished footprinting at the site and an antibody super-shift reaction showed that Sp1 is one of the factors binding the consensus site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
20	super	super	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	shift	shift	ADJ	JJ	Degree=Pos	_	_	_	_
23	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	one	one	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2803
# text = The Sp1 site also co-localizes with a DNase I hypersensitive site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	co-localizes	co-localize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2804
# text = The results indicate that DNA methylation, chromatin structure, and transactivation at an Sp1 site contribute to the highly restricted expression of this myelomonocytic lineage specific gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
9	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	highly	highly	ADV	RB	_	_	_	_	_
21	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2805
# text = Document 003001171 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001171	003001171	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2806
# text = The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	19	19	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	target	target	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2807
# text = The CD19 protein is expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells and has been implicated as a signal-transducing receptor in the control of proliferation and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	19	19	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	terminally	terminally	ADV	RB	_	_	_	_	_
21	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	transducing	transducing	VERB	VBG	VerbForm=Ger	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	control	control	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2808
# text = Here we demonstrate complete correlation between the expression pattern of the CD19 gene and the B-cell-specific transcription factor BSAP in a large panel of B-lymphoid cell lines.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
5	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	19	19	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
27	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2809
# text = The human CD19 gene has been cloned, and several BSAP-binding sites have been mapped by in vitro protein-DNA binding studies.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	19	19	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2810
# text = In particular, a high-affinity BSAP-binding site instead of a TATA sequence is located in the -30 promoter region upstream of a cluster of heterogeneous transcription start sites.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
8	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	instead	instead	ADV	RB	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	TATA	TATA	NOUN	NN	Number=Sing	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	30	30	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	start	start	NOUN	NN	Number=Sing	_	_	_	_
33	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2811
# text = Moreover, this site is occupied by BSAP in vivo in a CD19-expressing B-cell line but not in plasma or HeLa cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	CD19	CD19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-expressing	-expressing	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	HeLa	Hela	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2812
# text = This high-affinity site has been conserved in the promoters of both human and mouse CD19 genes and was furthermore shown to confer B-cell specificity to a beta-globin reporter gene in transient transfection experiments.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	human	human	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
17	CD	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	19	19	NUM	CD	NumType=Card	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	furthermore	furthermore	ADV	RB	_	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
35	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
39	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
40	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2813
# text = In addition, BSAP was found to be the only abundant DNA-binding activity of B-cell nuclear extracts that interacts with the CD19 promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
11	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	19	19	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2814
# text = Together, this evidence strongly implicates BSAP in the regulation of the CD19 gene.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	strongly	strongly	ADV	RB	_	_	_	_	_
6	implicates	implicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	19	19	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2815
# text = Document 003001172 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001172	003001172	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2816
# text = Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.
1	Simple	simple	ADJ	JJ	Degree=Pos	_	_	_	_
2	derivation	derivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TFIID	TFIID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
8	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	Schizosaccharomyces	Schizosaccharomyce	NOUN	NNS	Number=Plur	_	_	_	_
14	pombe	pombe	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2817
# text = Resolution of whole cell extract through two chromatographic steps yields a single protein fraction requiring only the addition of TFIID for the initiation of transcription at RNA polymerase II promoters.
1	Resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	chromatographic	chromatographic	ADJ	JJ	Degree=Pos	_	_	_	_
9	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
10	yields	yield	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
15	requiring	require	VERB	VBG	VerbForm=Ger	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	TFIID	tFIId	PROPN	NNP	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
28	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2818
# text = This approach allows the convenient generation of RNA polymerase II transcription systems from Saccharomyces cerevisiae, human lymphocytes, and Schizosaccharomyces pombe.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
3	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	convenient	convenient	ADJ	JJ	Degree=Pos	_	_	_	_
6	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
9	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	Saccharomyces	Saccharomyce	NOUN	NNS	Number=Plur	_	_	_	_
15	cerevisiae	cerevisia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Schizosaccharomyces	Schizosaccharomyce	NOUN	NNS	Number=Plur	_	_	_	_
22	pombe	pombe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2819
# text = TFIIDs from all three organisms are interchangeable among all three systems.
1	TFIIDs	TFIid	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	interchangeable	interchangeable	ADJ	JJ	Degree=Pos	_	_	_	_
8	among	among	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2820
# text = The S. cerevisiae and Sch. pombe systems support effects of acidic activator proteins, provided a further protein fraction from S. cerevisiae is supplied.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
3	cerevisiae	cerevisia	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Sch	Sch	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_
7	pombe	pombe	ADJ	JJ	Degree=Pos	_	_	_	_
8	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
9	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	provided	provide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
23	cerevisiae	cerevisiae	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	supplied	supply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2821
# text = This further fraction is distinct from the mediator of transcriptional activation described previously and represents a second component in addition to general initiation factors that may facilitate a response to acidic activators.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
23	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
32	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2822
# text = Document 003001173 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001173	003001173	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2823
# text = I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	masks	mask	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2824
# text = The active nuclear form of the NF-kappa B transcription factor complex is composed of two DNA binding subunits, NF-kappa B p65 and NF-kappa B p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	form	form	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	both	both	CCONJ	CC	_	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	which	which	DET	WDT	PronType=Int	_	_	_	_
37	share	share	NOUN	NN	Number=Sing	_	_	_	_
38	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
39	N-	N-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
41	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
42	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
47	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
48	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2825
# text = The NF-kappa B p65 subunit provides the transactivation activity in this complex and serves as an intracellular receptor for a cytoplasmic inhibitor of NF-kappa B, termed I kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	p65	p65	NUM	CD	NumType=Card	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
24	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2826
# text = In contrast, NF-kappa B p50 alone fails to stimulate kappa B-directed transcription, and based on prior in vitro studies, is not directly regulated by I kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	p50	p50	NUM	CD	NumType=Card	_	_	_	_
9	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
10	fails	fail	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
25	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	directly	directly	ADV	RB	_	_	_	_	_
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2827
# text = To investigate the molecular basis for the critical regulatory interaction between NF-kappa B and I kappa B/MAD-3, a series of human NF-kappa B p65 mutants was identified that functionally segregated DNA binding, I kappa B-mediated inhibition, and I kappa B-induced nuclear exclusion of this transcription factor.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	series	series	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	_
34	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	functionally	functionally	ADV	RB	_	_	_	_	_
39	segregated	segregate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
41	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
51	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
52	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
56	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
59	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
60	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2828
# text = Results from in vivo expression studies performed with these NF-kappa B p65 mutants revealed the following:
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	p65	p65	NUM	CD	NumType=Card	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2829
# text = 1) I kappa B/MAD-3 completely inhibits NF-kappa B p65-dependent transcriptional activation mediated through the human immunodeficiency virus type 1 kappa
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/MAD	/MAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	completely	completely	ADV	RB	_	_	_	_	_
10	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2830
# text = B enhancer in human T lymphocytes, 2) the binding of I kappa B/MAD-3 to NF-kappa B p65 is sufficient to retarget NF-kappa B p65 from the nucleus to the cytoplasm, 3) selective deletion of the functional nuclear localization signal present in the Rel homology domain of NF-kappa B p65 disrupts its ability to engage I kappa B/MAD-3, and 4) the unique C-terminus of NF-kappa B p65 attenuates its own nuclear localization and contains sequences that are required for I kappa B-mediated inhibition of NF-kappa B p65 DNA binding activity.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	2	2	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/MAD	/MAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	retarget	retarget	VERB	VB	VerbForm=Inf	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	3	3	X	LS	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
44	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
48	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
49	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
50	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
51	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
55	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
56	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
61	B	b	NOUN	NN	Number=Sing	_	_	_	_
62	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
63	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
64	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
65	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
66	to	to	PART	TO	_	_	_	_	_
67	engage	engage	VERB	VB	VerbForm=Inf	_	_	_	_
68	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
69	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
70	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
72	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	4	4	X	LS	_	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
80	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
82	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
87	B	b	NOUN	NN	Number=Sing	_	_	_	_
88	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
89	attenuates	attenuate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
90	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
91	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
92	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
93	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
94	and	and	CCONJ	CC	_	_	_	_	_
95	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
96	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
97	that	that	PRON	WDT	PronType=Rel	_	_	_	_
98	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
99	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
100	for	for	SCONJ	IN	_	_	_	_	_
101	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
102	kappa	kappa	ADV	RB	_	_	_	_	_
103	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
104	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
105	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
106	of	of	ADP	IN	_	_	_	_	_
107	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
108	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
109	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
110	B	b	NOUN	NN	Number=Sing	_	_	_	_
111	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
112	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
113	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
114	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
115	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2831
# text = Together, these findings suggest that the nuclear localization signal and transactivation domain of NF-kappa B p65 constitute a bipartite system that is critically involved in the inhibitory function of I kappa B/MAD-3.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	constitute	constitute	NOUN	NN	Number=Sing	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	bipartite	bipartite	ADJ	JJ	Degree=Pos	_	_	_	_
23	system	system	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	critically	critically	ADV	RB	_	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
31	function	function	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2832
# text = Unexpectedly, our in vivo studies also demonstrate that I kappa B/MAD-3 binds directly to NF-kappa B p50.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/MAD	/mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	_
16	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
17	directly	directly	ADV	RB	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2833
# text = This interaction is functional as it leads to retargeting of NF-kappa B p50 from the nucleus to the cytoplasm.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	SCONJ	IN	_	_	_	_	_
9	retargeting	retarget	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2834
# text = However, no loss of DNA binding activity is observed, presumably reflecting the unique C-terminal domain that is distinct from that present in NF-kappa B p65.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	presumably	presumably	ADV	RB	_	_	_	_	_
13	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
16	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	present	present	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2835
# text = Document 003001174 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001174	003001174	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2836
# text = Evaluation of the role of ligand and thermal activation of specific DNA binding by in vitro synthesized human glucocorticoid receptor.
1	Evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	thermal	thermal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
17	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2837
# text = We have used a DNA-binding/immunoprecipitation assay to analyze the capacity of human glucocorticoid receptor (hGR), generated in rabbit reticulocyte lysates, to bind DNA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	DNA-	Dna-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
9	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
25	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
26	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2838
# text = In vitro translated hGR was indistinguishable from native hGR, as determined by migration on sodium dodecyl sulfate-polyacrylamide gels, sedimentation on sucrose density gradients, and reactivity with antipeptide antibodies generated against hGR.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
9	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
17	dodecyl	dodecyl	NOUN	NN	Number=Sing	_	_	_	_
18	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
21	gels	gel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	sedimentation	sedimentation	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	sucrose	sucrose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	density	density	NOUN	NN	Number=Sing	_	_	_	_
27	gradients	gradient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	antipeptide	antipeptide	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
34	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	against	against	ADP	IN	_	_	_	_	_
36	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2839
# text = In addition, cell-free synthesized hGR was capable of specific binding to glucocorticoid response element (GRE)-containing DNA fragments.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	synthesized	synthesized	ADJ	JJ	Degree=Pos	_	_	_	_
8	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2840
# text = Using this assay system, we have evaluated the contributions of ligand binding and heat activation to DNA binding by these glucocorticoid receptors.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	contributions	contribution	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2841
# text = In vitro translated hGR was capable of selective DNA binding even in the absence of glucocorticoid.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	even	even	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2842
# text = Treatment with dexamethasone or the antiglucocorticoid RU486 had no additional effect on the DNA-binding capacity when receptor preparations were maintained at 0 C (no activation).
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	RU486	Ru486	PROPN	NNP	Number=Sing	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	receptor	receptor	ADJ	JJ	Degree=Pos	_	_	_	_
20	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	0	0	NUM	CD	NumType=Card	_	_	_	_
25	C	C	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	no	no	DET	DT	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2843
# text = In contrast, addition of either ligand or antagonist in combination with a heat activation step promoted DNA binding by approximately 3-fold over that of heat-activated unliganded receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	step	step	NOUN	NN	Number=Sing	_	_	_	_
17	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	approximately	approximately	ADV	RB	_	_	_	_	_
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	over	over	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	unliganded	unliganded	ADJ	JJ	Degree=Pos	_	_	_	_
32	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2844
# text = Agonist (dexamethasone) was slightly more effective in supporting specific DNA binding than antagonist (RU486).
1	Agonist	Agonist	ADJ	JJS	Degree=Sup	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	slightly	slightly	ADV	RB	_	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RU486	RU486	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2845
# text = DNA binding by in vitro synthesized GR was blocked by the addition of sodium molybdate to the receptor preparations before steroid addition and thermal activation.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
6	synthesized	synthesized	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
15	molybdate	molybdate	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
20	before	before	ADP	IN	_	_	_	_	_
21	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	thermal	thermal	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2846
# text = Addition of KCl resulted in less DNA binding either due to blockage of DNA-receptor complex formation or disruption of the complexes.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	KCl	KCl	PROPN	NNP	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	due	due	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	blockage	blockage	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2847
# text = The specificity of DNA binding by cell-free synthesized hGR was analyzed further by examining the abilities of various DNAs to compete for binding to a naturally occurring GRE found in the mouse mammary tumor virus-long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
10	synthesized	synthesized	ADJ	JJ	Degree=Pos	_	_	_	_
11	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	further	further	ADV	RB	_	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	examining	examine	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	abilities	abilitie	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	DNAs	Dna	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	naturally	naturally	ADV	RB	_	_	_	_	_
29	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
30	GRE	Gre	PROPN	NNP	Number=Sing	_	_	_	_
31	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
35	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
40	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
41	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2848
# text = Oligonucleotides containing the consensus GRE were the most efficient competitors, and fragments containing regulatory sequences from glucocorticoid-repressible genes were somewhat competitive, whereas single stranded oligonucleotides were unable to compete for mouse mammary tumor virus-long terminal repeat DNA binding, except when competitor was present at extremely high concentrations.
1	Oligonucleotides	Oligonucleotides	SCONJ	IN	_	_	_	_	_
2	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
5	GRE	GRE	ADV	RB	PronType=Dem	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	most	most	ADV	RBS	_	_	_	_	_
9	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
10	competitors	competitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	repressible	repressible	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	somewhat	somewhat	ADV	RB	_	_	_	_	_
24	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
28	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
36	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
37	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
38	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
41	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
42	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
43	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
44	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	except	except	ADP	IN	_	_	_	_	_
47	when	when	ADV	WRB	PronType=Int	_	_	_	_
48	competitor	competitor	NOUN	NN	Number=Sing	_	_	_	_
49	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
50	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
51	at	at	ADP	IN	_	_	_	_	_
52	extremely	extremely	ADV	RB	_	_	_	_	_
53	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
54	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2849
# text = Together these studies indicate that hGR synthesized in rabbit reticulocyte lysates displays many of the same properties, including GRE-specific DNA binding, observed for glucocorticoid receptor present in cytosolic extracts of mammalian cells and tissues.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	_
7	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
10	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
11	lysates	lysate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	GRE	Gre	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2850
# text = Similarities between the effects of dexamethasone and RU486 suggest that the antiglucocorticoid properties of RU486 do not occur at the level of specific DNA binding.
1	Similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	_
9	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	RU486	Ru486	NUM	CD	NumType=Card	_	_	_	_
16	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2851
# text = Document 003001175 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001175	003001175	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2852
# text = Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.
1	Thrombin-	Thrombin-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	p65	p65	NUM	CD	NumType=Card	_	_	_	_
4	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
18	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2853
# text = We investigated the mechanisms by which proinflammatory mediator, thrombin, released during intravascular coagulation and tissue injury, induces ICAM-1 (CD54) expression in endothelial cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	DET	WDT	PronType=Int	_	_	_	_
7	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	intravascular	intravascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
18	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
21	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CD54	CD54	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2854
# text = Stimulation of HUVEC with thrombin resulted in dose- and time-dependent increases in ICAM-1 mRNA and cell surface expression and in ICAM-1-dependent endothelial adhesivity toward polymorphonuclear leukocytes.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	thrombin	thrombin	ADP	IN	_	_	_	_	_
6	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
32	adhesivity	adhesivity	NOUN	NN	Number=Sing	_	_	_	_
33	toward	toward	ADP	IN	_	_	_	_	_
34	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2855
# text = Transient transfection of endothelial cells with ICAM-1 promoter luciferase reporter gene (ICAM-1LUC) constructs indicated that deletion of upstream NF-kappa B site (-533 bases from translation start site) had no effect on thrombin responsiveness, whereas mutation/deletion of downstream NF-kappa B site (-223 bases from the translation start site) prevented the activation of ICAM-1 promoter, indicating that the downstream NF-kappa B site is critical for thrombin inducibility.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-1LUC	-1luc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
19	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
30	533	533	NUM	CD	NumType=Card	_	_	_	_
31	bases	base	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
34	start	start	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	no	no	DET	DT	_	_	_	_	_
39	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
42	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	whereas	whereas	SCONJ	IN	_	_	_	_	_
45	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
50	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
53	B	b	NOUN	NN	Number=Sing	_	_	_	_
54	site	site	NOUN	NN	Number=Sing	_	_	_	_
55	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
56	223	223	NUM	CD	NumType=Card	_	_	_	_
57	bases	base	NOUN	NNS	Number=Plur	_	_	_	_
58	from	from	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
61	start	start	NOUN	NN	Number=Sing	_	_	_	_
62	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	)	)	PUNCT	-RRB-	_	_	_	_	_
64	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	1	1	NUM	CD	NumType=Card	_	_	_	_
71	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
74	that	that	SCONJ	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
77	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
79	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
80	B	b	NOUN	NN	Number=Sing	_	_	_	_
81	site	site	NOUN	NN	Number=Sing	_	_	_	_
82	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
83	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
84	for	for	ADP	IN	_	_	_	_	_
85	thrombin	thrombin	ADP	IN	_	_	_	_	_
86	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
87	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2856
# text = NF-kappa B-directed luciferase activity increased approximately 3-fold when cells transfected with the plasmid pNF-kappa BLUC containing five copies of consensus NF-kappa B site linked to a minimal adenovirus E1B promoter-luciferase gene were exposed to thrombin, indicating that activation of NF-kappa B was essential for thrombin response.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
20	pNF	pNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	BLUC	BLUC	NOUN	NN	Number=Sing	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	five	five	NUM	CD	NumType=Card	_	_	_	_
26	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
38	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
39	E1B	E1b	NOUN	NN	Number=Sing	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
50	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
51	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
56	B	b	PROPN	NNP	Number=Sing	_	_	_	_
57	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
58	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
59	for	for	ADP	IN	_	_	_	_	_
60	thrombin	thrombin	ADP	IN	_	_	_	_	_
61	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2857
# text = Gel supershift assays demonstrated that thrombin induced binding of NF-kappa Bp65 (Rel A) to downstream NF-kappa B site of the ICAM-1 promoter.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	supershift	supershift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	thrombin	thrombin	ADP	IN	_	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	Bp65	Bp65	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
16	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2858
# text = Thrombin receptor activation peptide, a 14-amino-acid peptide representing the new NH2 terminus of proteolytically activated receptor-1, mimicked thrombin's action in inducing ICAM-1 expression.
1	Thrombin	Thrombin	ADP	IN	_	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
16	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	_
17	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	proteolytically	proteolytically	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	's	's	PART	POS	_	_	_	_	_
28	action	action	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	SCONJ	IN	_	_	_	_	_
30	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
31	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2859
# text = These data indicate that thrombin activates endothelial ICAM-1 expression and polymorphonuclear leukocyte adhesion by NF-kappa Bp65 binding to the downstream NF-kappa B site of ICAM-1 promoter after proteolytically activated receptor-1 activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	Bp65	Bp65	PROPN	NNP	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	proteolytically	proteolytically	ADV	RB	_	_	_	_	_
37	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-1	-1	NUM	CD	NumType=Card	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2860
# text = Document 003001176 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001176	003001176	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2861
# text = Constitutive expression c-fos, c-jun, and NF kappa B mRNA is in nucleated fetal blood cells and up-regulation of c-fos and c-jun with anti-CD3 stimulation.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	B	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	nucleated	nucleated	ADJ	JJ	Degree=Pos	_	_	_	_
17	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2862
# text = Fetal and neonatal lymphocytes are relatively resistant to activation and cytokine production when stimulated either via their T-cell antigen receptors or lectins.
1	Fetal	Fetal	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	relatively	relatively	ADV	RB	_	_	_	_	_
7	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	when	when	ADV	WRB	PronType=Int	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	either	either	ADV	RB	_	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2863
# text = The molecular mechanism(s) responsible for this phenomenon have not been clearly elucidated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	s	s	X	AFX	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	clearly	clearly	ADV	RB	_	_	_	_	_
15	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2864
# text = We have hypothesized that such defects in fetal/neonatal T-cell activation may be due to lack of expression of the transcriptional regulatory elements required for T-cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2865
# text = We used reverse transcriptase-polymerase chain reaction to examine both fetal and term neonatal cord bloods for mRNA expression of three transcription factors implicated in T-cell activation:
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
4	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	examine	examine	NOUN	NN	Number=Sing	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	fetal	fetal	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	term	term	NOUN	NN	Number=Sing	_	_	_	_
15	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
17	bloods	blood	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	three	three	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2866
# text = c-jun, c-fos, and NF kappa B (p50 subunit).
1	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2867
# text = We demonstrate that mRNAs for all three of these regulatory factors are expressed in fetal blood cells by the 27th week of gestation and in term cord bloods.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	27th	27th	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
21	week	week	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	gestation	gestation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	term	term	NOUN	NN	Number=Sing	_	_	_	_
27	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
28	bloods	bloods	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2868
# text = Activation of term infant cord blood mononuclear cells with anti-CD3 monoclonal antibodies resulted in up-regulation of both c-jun and c-fos mRNAs within 15 min of stimulation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	term	term	NOUN	NN	Number=Sing	_	_	_	_
4	infant	infant	NOUN	NN	Number=Sing	_	_	_	_
5	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
26	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
27	within	within	ADP	IN	_	_	_	_	_
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	min	min	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2869
# text = However, secretion of IL-2 by anti-CD3-stimulated cord blood mononuclear cells was still blunted compared with control cells from adults.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-stimulated	-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
11	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	still	still	ADV	RB	_	_	_	_	_
17	blunted	blunt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2870
# text = We conclude that fetal nucleated blood cells constitutively express important genes for cytokine regulation and are able to increase intracellular accumulation of the mRNAs for these factors in response to anti-CD3 stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
5	nucleated	nucleate	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2871
# text = Thus, qualitative differences in the capacity to regulate these factors could not be shown in fetal blood cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	qualitative	qualitative	ADJ	JJ	Degree=Pos	_	_	_	_
4	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2872
# text = Quantitative experiments comparing binding of these transcription factors to the IL-2 promoter are currently under investigation.
1	Quantitative	Quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	currently	currently	ADV	RB	_	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2873
# text = Document 003001177 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001177	003001177	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2874
# text = The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor necrosis factor-alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD36	CD36	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	density	density	NOUN	NN	Number=Sing	_	_	_	_
16	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
17	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2875
# text = The binding of oxidized low-density lipoprotein (Ox LDL) by monocyte-macrophages causes pleiotropic effects, including changes in gene expression, and is thought to represent an early event in atherogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	oxidized	oxidize	ADJ	JJ	Degree=Pos	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	density	density	NOUN	NN	Number=Sing	_	_	_	_
8	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
11	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
17	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	event	event	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2876
# text = The integral membrane glycoprotein CD36 appears to play a physiological role in binding and uptake of Ox LDL by monocyte-macrophages, although the molecular events associated with CD36-Ox LDL interaction are unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
5	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	36	36	NUM	CD	NumType=Card	_	_	_	_
7	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
19	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	although	although	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	events	event	NOUN	NNS	Number=Plur	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
33	LDL	Ldl	PROPN	NNP	Number=Sing	_	_	_	_
34	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2877
# text = To approach this issue, we used CD36 transfected Chinese hampster ovary (CHO) cells, exposed them to Ox LDL, and determined changes in the activity of the transcription factor NF-kappaB.
1	To	to	PART	TO	_	_	_	_	_
2	approach	approach	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	issue	issue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	36	36	NUM	CD	NumType=Card	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
12	hampster	hampster	NOUN	NN	Number=Sing	_	_	_	_
13	ovary	ovary	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CHO	cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
23	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2878
# text = We report here that Ox LDL enhanced DNA binding activity of nuclear extracts to an NF-kappaB sequence following activation of CD36-producing CHO cells with the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
6	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
7	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	CD36	CD36	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-producing	-produce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	CHO	Chough	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
31	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2879
# text = This enhanced DNA binding activity was inhibited by coincubation of CD36 transfected cells with the human CD36-specific antibody OKM5.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	coincubation	coincubation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD36	CD36	NUM	CD	NumType=Card	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
20	OKM5	Okm5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2880
# text = We also determined that activation of NF-kappaB
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2881
# text = DNA binding activity required an intact carboxyl-terminal cytoplasmic segment on CD36.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
7	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
11	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2882
# text = Our results support the idea that human CD36 mediates signal transduction events in response to Ox LDL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	_
9	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
17	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2883
# text = Document 003001178 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001178	003001178	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2884
# text = One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	base	base	NOUN	NN	Number=Sing	_	_	_	_
3	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
4	change	change	NOUN	NN	Number=Sing	_	_	_	_
5	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	kB	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-enhancer	-enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2885
# text = The inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-like sequence GGGATTTCACC as an essential cis-acting enhancer motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Il	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	GGGATTTCACC	Gggatttcacc	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
31	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
35	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2886
# text = When cloned in multiple copies this so-called TCEd (distal T cell element) acts as an inducible proto-enhancer element in E14
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
6	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	E14	E14	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2887
# text = T lymphoma cells, but not in HeLa cells.
1	T	t	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2888
# text = In extracts of induced, Il-2 secreting El4 cells three individual protein factors bind to TCEd DNA.
1	In	in	ADP	IN	_	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Il	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	secreting	secreting	NOUN	NN	Number=Sing	_	_	_	_
10	El4	El4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	three	three	NUM	CD	NumType=Card	_	_	_	_
13	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	TCEd	TCEd	VERB	VB	VerbForm=Inf	_	_	_	_
19	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2889
# text = The binding of the most prominent factor, named TCF-1 (T cell factor
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	most	most	ADV	RBS	_	_	_	_	_
6	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2890
# text = 1), is correlated with the proto-enhancer activity of TCEd.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-enhancer	-enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2891
# text = TCF-1 consists of two polypeptides of about 50 kD and 105 kD; the former seems to be related to the 50 kD polypeptide of NF-kB.
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	about	about	ADP	IN	_	_	_	_	_
10	50	50	NUM	CD	NumType=Card	_	_	_	_
11	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	105	105	NUM	CD	NumType=Card	_	_	_	_
14	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
18	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	50	50	NUM	CD	NumType=Card	_	_	_	_
25	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
26	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2892
# text = Purified NF-kB is also able to bind to the TCEd, but TCF-1 binds stronger than NF-kB to TCEd DNA.
1	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
19	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	TCEd	TCEd	VERB	VB	VerbForm=Inf	_	_	_	_
26	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2893
# text = The conversion of the TCEd to a 'perfect' NF-kB binding site leads to a tighter binding of NF-kB to TCEd DNA and, as a functional consequence, to the activity of the 'converted' TCEd motifs in HeLa cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	conversion	conversion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
9	perfect	perfect	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	tighter	tighter	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	_
27	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
33	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
41	converted	converted	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	'	'	PUNCT	''	_	_	_	_	_
43	TCEd	Tce	NOUN	NN	Number=Sing	_	_	_	_
44	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2894
# text = Thus, the substitution of the underlined A residue to a C within the GGGATTTCACC motif abolishes its T cell-restricted activity and leads to its functioning in both El4 cells and HeLa cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	underlined	underlin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GGGATTTCACC	GGGATTTCACC	PROPN	NNP	Number=Sing	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
17	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	functioning	functioning	VERB	VBG	VerbForm=Ger	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	El4	El4	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2895
# text = These results indicate that lymphocyte-specific factors binding to the TCEd are involved in the control of T cell specific-transcription of the Il-2 gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TCEd	tced	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Il	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2896
# text = Document 003001179 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001179	003001179	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2897
# text = CD2 signalling induces phosphorylation of CREB in primary lymphocytes.
1	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
2	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2898
# text = Promoter sequences responsive to cyclic AMP (cAMP) are found in a number of cellular genes, and bind transcription factors of the cAMP response element binding protein (CREB)/activating transcription factor-1 (ATF-1) family.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
3	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
6	AMP	Amp	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	element	element	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-1	-1	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ATF	Atf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2899
# text = We have used a human T-lymphotropic virus type 1 (HTLV-1) model of cAMP response element (CRE) transcription to investigate the influence of lymphocyte activation on transcription from homologous regions in the viral promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	model	model	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
36	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2900
# text = We previously demonstrated increased HTLV-1 transcription following CD2 but not CD3 receptor cross-linking.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2901
# text = We hypothesized that this increased viral transcription was mediated, in part, through the phosphorylation of CREB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2902
# text = Therefore, we investigated CD2 and CD3 receptor-mediated signalling in primary human peripheral blood mononuclear cells (PBMC).
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2903
# text = CD2, but not CD3, cross-linking increased cAMP detected by competitive enzyme-linked immunosorbent assay (ELISA) approximately fourfold.
1	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	not	not	ADV	RB	_	_	_	_	_
5	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
8	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
18	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	approximately	approximately	ADV	RB	_	_	_	_	_
23	fourfold	fourfold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2904
# text = CD2 cross-linking concurrently increased phosphorylation of CREB detected by immunoblot assay eightfold.
1	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	concurrently	concurrently	ADV	RB	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
13	eightfold	eightfold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2905
# text = Consistent with post-translational regulation, no change in total level of CREB protein was observed.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	post	post	X	AFX	_	_	_	_	SpaceAfter=No
4	-translational	-translational	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	change	change	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2906
# text = Phosphorylation of CREB occurred through a herbimycin A and Rp-cAMP- sensitive pathway, suggesting phosphorylation required antecedent activation of both protein tyrosine kinases (PTK) and protein kinase A (PKA).
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
4	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Rp-cAMP	Rp-camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	antecedent	antecedent	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	A	A	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2907
# text = Both CD2 and CD3 cross-linking increased binding of nuclear proteins to a radiolabelled CRE oligonucleotide probe in electrophoretic mobility shift assays suggesting that lymphocyte activation enhances binding independently of phosphorylation of CREB at serine 133.
1	Both	both	DET	DT	_	_	_	_	_
2	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
5	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	radiolabelled	radiolabell	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
16	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
17	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	independently	independently	ADV	RB	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
36	133	133	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2908
# text = These data indicate specific modulation of the CREB/ATF-1 family of transcription factors by the CD2 signalling pathway and suggest CD2 receptor modulation of CRE-mediated transcription following ligand engagement (e.g. cell-to-cell contact).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
20	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
24	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
33	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
34	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	e.g.	e.g.	X	FW	_	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	contact	contact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2909
# text = Document 003001180 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001180	003001180	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2910
# text = Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
16	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2911
# text = Human immunodeficiency virus type-1 (HIV-1) transcription is dependent on the interaction of host-cell transcription factors with cis-regulatory DNA elements within the viral long terminal repeat (LTR).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	within	within	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
32	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
33	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
34	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2912
# text = Much attention has focused on the series of sequence elements upstream of the transcriptional initiation site in the U3 region of the LTR including the Sp1 and NF-kappaB binding sites.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	attention	attention	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	series	series	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	U3	U3	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2913
# text = Recent studies, however, demonstrate that the transcribed 5'-untranslated leader region (5'-UTR) also contains important transcriptional elements.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcribed	transcribe	NOUN	NN	Number=Sing	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
12	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
13	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
18	UTR	Utr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2914
# text = These regulatory elements situated downstream of transcription interact with constitutive and inducible transcription factors, mediate transmission of cellular activation signals, and are important for efficient HIV-1 transcription and replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	situated	situate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2915
# text = The 5'-UTR contains binding sites for the transcription factors AP-1, NF-kappaB, NF-AT, IRF, and Sp1. Mutations in these binding sites can interfere with the viral response to cell activation signals, decrease LTR transcription, and inhibit viral replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	UTR	UTR	PROPN	NNP	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_
30	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
36	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
47	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
53	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2916
# text = The 5'-UTR also interacts with a specific nucleosome that is rapidly displaced during transcriptional activation of the latent provirus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	UTR	UTR	PROPN	NNP	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	nucleosome	nucleosome	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	displaced	displace	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
22	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2917
# text = We propose that the inducible transcription factor binding sites in the 5'-UTR comprise a downstream enhancer domain that can function independent of, or in concert with, the LTR promoter to rapidly increase latent proviral transcription in response to cell activation signals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	UTR	UTR	ADV	RB	_	_	_	_	_
16	comprise	comprise	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	LTR	LTR	ADJ	JJ	Degree=Pos	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	rapidly	rapidly	ADV	RB	_	_	_	_	_
37	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
38	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
39	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	response	response	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2918
# text = In this review, we describe the host-cell transcription factors that interact with the 5'-UTR and discuss their role in the transcriptional regulation of HIV-1 gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	's	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	UTR	UTR	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2919
# text = Document 003001181 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001181	003001181	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2920
# text = T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	non-lineage	non-lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2921
# text = The GATA-3 transcription factor is required for development of the T-cell lineage and Th2 cytokine gene expression in CD4 T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
23	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2922
# text = We have mapped the DNase-I-hypersensitive (HS) regions of the human GATA-3 gene in T-cells and non-T-cells and studied their transcriptional activities.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HS	h	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	non-T-	non-t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2923
# text = HS I-III, located 5' from the transcriptional initiation site, were found in hematopoietic and non-hematopoietic cells, whereas HS IV-VII, located 3' from the transcriptional start site, were exclusively observed in T-cells.
1	HS	h	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	III	Iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	non-hematopoietic	non-hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
25	IV	IV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	VII	VII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	'	'	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	start	start	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	exclusively	exclusively	ADV	RB	_	_	_	_	_
40	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2924
# text = Among these hypersensitive sites, two transcriptional control elements were found, one in the first intron of the GATA-3 gene and the other between 8.3 and 5.9 kilobases 5' from the GATA-3 transcriptional initiation site.
1	Among	among	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
17	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	between	between	ADP	IN	_	_	_	_	_
28	8.3	8.3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	5.9	5.9	NUM	CD	NumType=Card	_	_	_	_
31	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
32	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	NOUN	NNS	Number=Plur	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	3	3	NUM	CD	NumType=Card	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2925
# text = The first intron acted as a strong transcriptional activator in a position-dependent manner and with no cell-type specificity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
4	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2926
# text = The upstream regulatory element could confer T-cell specificity to the GATA-3 promoter activity, and analysis of this region revealed a 707-base pair silencer that drastically inhibited GATA-3 promoter activity in non-T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
7	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	707	707	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-base	-base	NOUN	NN	Number=Sing	_	_	_	_
27	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
28	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	drastically	drastically	ADV	RB	_	_	_	_	_
31	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	3	3	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	non-T-	non-t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2927
# text = Two CAGGTG E-boxes, located at the 5'- and 3'-ends of the silencer, were necessary for this silencer activity.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	CAGGTG	Caggtg	ADJ	JJ	Degree=Pos	_	_	_	_
3	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	ends	end	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2928
# text = The 3'-CAGGTG E-box could bind USF proteins, the ubiquitous repressor ZEB, or the basic helix-loop-helix proteins E2A and HEB, and we showed that a competition between ZEB and E2A/HEB proteins is involved in the silencer activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	CAGGTG	CAGGTG	NOUN	NN	Number=Sing	_	_	_	_
6	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	USF	USF	ADP	RP	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
21	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	HEB	HEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
31	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
35	between	between	ADP	IN	_	_	_	_	_
36	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
40	HEB	Heb	PROPN	NNP	Number=Sing	_	_	_	_
41	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2929
# text = Document 003001182 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001182	003001182	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2930
# text = Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
11	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2931
# text = Three subtypes of retinoic acid receptors (RAR), termed RAR alpha, RAR beta, and RAR gamma, have been described.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	RAR	RAR	ADP	IN	_	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
16	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
20	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2932
# text = They are composed of different structural domains, including distinct domains for DNA and ligand binding.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
7	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2933
# text = RARs specifically bind all-trans-retinoic acid (RA), 9-cis-RA, and retinoid analogs.
1	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	_
2	specifically	specifically	ADV	RB	_	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	all	all	DET	DT	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	9-	9-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	analogs	analog	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2934
# text = In this study, we examined the functional role of cysteine and arginine residues in the ligand-binding domain of hRAR alpha (hRAR alpha-LBD, amino acids 154 to 462).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	arginine	arginine	NUM	CD	NumType=Card	_	_	_	_
14	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	hRAR	hRAR	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	hRAR	hRAR	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	LBD	lbd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	amino	amino	DET	DT	_	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
32	154	154	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	462	462	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2935
# text = All conserved cysteine and arginine residues in this domain were mutated by site-directed mutagenesis, and the mutant proteins were characterized by blocking reactions, ligand-binding experiments, transactivation assays, and protease mapping.
1	All	all	DET	DT	_	_	_	_	_
2	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
6	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	SCONJ	IN	_	_	_	_	_
25	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
26	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
34	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
38	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2936
# text = Changes of any cysteine residue of the hRAR alpha-LBD had no significant influence on the binding of all-trans RA or 9-cis RA.
1	Changes	change	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
5	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hRAR	hRAR	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	LBD	LBD	PROPN	NNP	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
15	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	all	all	DET	DT	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
23	RA	RA	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
28	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2937
# text = Interestingly, residue C-235 is specifically important in antagonist binding.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	residue	residue	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	235	235	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	antagonist	antagonist	ADJ	JJ	Degree=Pos	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2938
# text = With respect to arginine residues, only the two single mutations of R-276 and R-394 to alanine showed a dramatic decrease of agonist and antagonist binding whereas the R272A mutation showed only a slight effect.
1	With	with	ADP	IN	_	_	_	_	_
2	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	arginine	arginine	VERB	VB	VerbForm=Inf	_	_	_	_
5	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
11	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	R-	R-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	276	276	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	R-	R-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	394	394	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	whereas	whereas	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	R272	R272	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
34	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	only	only	ADV	RB	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
38	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2939
# text = For all other arginine mutations, no differences in affinity were detectable.
1	For	for	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2940
# text = The two mutations R217A and R294A caused an increased binding efficiency for antagonists but no change in agonist binding.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	R217A	R217A	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	R294	R294	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	A	A	PROPN	NNP	Number=Sing	_	_	_	_
8	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	change	change	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
20	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2941
# text = From these results, we can conclude that electrostatic interactions of retinoids with the RAR alpha-LBD play a significant role in ligand binding.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	conclude	conclude	VERB	VB	VerbForm=Inf	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	electrostatic	electrostatic	ADJ	JJ	Degree=Pos	_	_	_	_
10	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	LBD	lbd	PROPN	NNP	Number=Sing	_	_	_	_
19	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2942
# text = In addition, antagonists show distinctly different requirements for efficient binding, which may contribute to their interference in the ligand-inducible transactivation function of RAR alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	distinctly	distinctly	ADV	RB	_	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Int	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2943
# text = Document 003001183 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001183	003001183	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2944
# text = Abundant expression of erythroid transcription factor P45 NF-E2 mRNA in human peripheral granurocytes.
1	Abundant	Abundant	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	P45	P45	PROPN	NNP	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	E2	E2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	granurocytes	granurocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2945
# text = Transcription factor NF-E2 is crucial for regulation of erythroid-specific gene expression.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2946
# text = p45 subunit of NF-E2 contains a basic-leucine zipper domain and dimerizes with the small Maf family protein to form functional NF-E2 complex.
1	p45	p45	NUM	CD	NumType=Card	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
12	zipper	zipper	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dimerizes	dimerize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
19	Maf	Maf	NOUN	NN	Number=Sing	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
24	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2947
# text = While p45 expression was shown to be restricted to erythroid cells, megakaryocytes and mast cells in hematopoietic lineage, we found in this study that p45 mRNA is abundantly transcribed in the granulocyte fraction of human peripheral blood cells.
1	While	while	SCONJ	IN	_	_	_	_	_
2	p45	p45	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	erythroid	erythroid	VERB	VB	VerbForm=Inf	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	study	study	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	p45	p45	NUM	CD	NumType=Card	_	_	_	_
28	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	abundantly	abundantly	ADV	RB	_	_	_	_	_
31	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
39	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2948
# text = As neutrophils occupy approximately 92% of the cells in granulocyte fraction of human peripheral blood cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	occupy	occupy	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
12	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2949
# text = As neutrophils occupy approximately 92% of the cells in this fraction, the cells expressing p45 is most likely to be neutrophils.
1	As	as	SCONJ	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	occupy	occupy	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	p45	p45	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2950
# text = p45 mRNA is also expressed in HL-60 promyelocytes, albeit the expression level is much lower than that of the granulocyte fraction.
1	p45	p45	NUM	CD	NumType=Card	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	albeit	albeit	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	much	much	ADV	RB	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2951
# text = HL-60 cells were found to express mafK mRNA, indicating the presence of genuine NF-E2 complex in the cells.
1	HL	Hl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	60	60	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
9	mafK	mafK	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	genuine	genuine	PROPN	NNP	Number=Sing	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	E2	e2	NUM	CD	NumType=Card	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2952
# text = Although p45 mRNA is transcribed from two different promoters, aNF-E2 promoter and fNF-E2 promoter, in erythroid and megakaryocytic lineage cells, p45 mRNA is transcribed only from aNF-E2 promoter.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	p45	p45	PROPN	NNP	Number=Sing	_	_	_	_
3	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	aNF	anf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	E2	e2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	fNF	fnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	E2	e2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	p45	p45	NUM	CD	NumType=Card	_	_	_	_
29	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	only	only	ADV	RB	_	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	aNF	aNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	E2	E2	NUM	CD	NumType=Card	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2953
# text = The expression of p45 megakaryocytic lineage cells, p45 mRNA is transcribed only from aNF-E2 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p45	p45	NUM	CD	NumType=Card	_	_	_	_
5	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p45	p45	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	aNF	aNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	E2	E2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2954
# text = The expression of p45 mRNA in the neutrophils declined rapidly after transfer of the cells to in vitro culture and G-CSF could not sustain the expression from the down-regulation, suggesting the E2 may also participate in the regulation of neutrophil-specific gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p45	p45	NUM	CD	NumType=Card	_	_	_	_
5	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
9	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
19	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
23	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	sustain	sustain	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	also	also	ADV	RB	_	_	_	_	_
39	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	neutrophil	neutrophil	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2955
# text = Document 003001184 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001184	003001184	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2956
# text = Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2957
# text = Stimulation of mature peripheral T cells by TCR engagement results in activation of signals that drive induction of cytokine gene expression and clonal expansion.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
9	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	drive	drive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2958
# text = However, under some conditions, engagement of the TCR leads instead to apoptosis.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	under	under	ADP	IN	_	_	_	_	_
4	some	some	DET	DT	_	_	_	_	_
5	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
11	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	instead	instead	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2959
# text = Recent studies demonstrate that TCR-stimulated apoptosis requires expression of CD95 ligand on activated T cells followed by an interaction between CD95 ligand and the CD95 receptor also expressed on this population.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	CD95	Cd95	NUM	CD	NumType=Card	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CD95	Cd95	PROPN	NNP	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	also	also	ADV	RB	_	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2960
# text = The experiments reported in this study were designed to address the signaling events triggered by TCR engagement that are important for regulating CD95 ligand gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	events	event	NOUN	NNS	Number=Plur	_	_	_	_
14	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
17	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	SCONJ	IN	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2961
# text = To approach this, we generated a luciferase reporter construct containing elements of the CD95 ligand promoter.
1	To	to	PART	TO	_	_	_	_	_
2	approach	approach	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	_
16	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2962
# text = Using a previously described mutant of the Jurkat T cell line, we show that proximal signaling events dependent on the presence of the CD45 tyrosine phosphatase are required for TCR-stimulated CD95 ligand expression.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	_
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	CD95	Cd95	NUM	CD	NumType=Card	_	_	_	_
35	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2963
# text = Transient transfection studies demonstrate further that TCR-stimulated activation of the Ras signaling pathway is required for optimal activation of CD95 ligand.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	further	further	SCONJ	IN	_	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2964
# text = Next, in an effort to determine critical transcription factors that regulate CD95 ligand expression, we demonstrate a cyclosporin A-sensitive nuclear factor-AT response element in the promoter region of this gene that is critical for optimal CD95 ligand reporter activity in stimulated T cells.
1	Next	next	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	effort	effort	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	at	NOUN	NN	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
42	CD95	Cd95	NUM	CD	NumType=Card	_	_	_	_
43	ligand	ligand	NUM	CD	NumType=Card	_	_	_	_
44	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	T	t	PROPN	NNP	Number=Sing	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2965
# text = Together, these studies begin a dissection of the biochemical events that lead to expression of CD95 ligand, a required step for TCR-induced apoptosis.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	begin	begin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
11	events	event	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
18	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	step	step	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	apoptosis.	apoptosis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2966
# text = Document 003001185 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001185	003001185	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2967
# text = Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7.
1	Dependence	Dependence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	erythropoietin	erythropoietin	VERB	VB	VerbForm=Inf	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	program	program	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2968
# text = Erythroid differentiation involves the activation of a number of erythroid-specific genes, most of which, including the globin genes and the erythropoietin receptor (Epo-R) gene, are, at least in part, regulated by the transcription factor GATA-1.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	at	at	ADV	RB	_	_	_	_	_
37	least	least	ADV	RBS	Degree=Sup	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
46	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2969
# text = In order to understand the relationship, if any, between expression of GATA-1, response to Epo and erythroid differentiation, we analyzed the expression of GATA-1, Epo-R and globin genes in an Epo-dependent human cell line, UT-7 Epo.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	if	if	SCONJ	IN	_	_	_	_	_
9	any	any	DET	DT	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-R	-r	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	Epo-dependent	Epo-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	7	7	NUM	CD	NumType=Card	_	_	_	_
49	Epo	Epo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2970
# text = The results were compared to those obtained with the parental granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent cell line, UT-7, which has a predominantly megakaryoblastic phenotype and is unable to proliferate continuously in the presence of Epo. UT-7 Epo and UT-7 expressed similar levels of GATA-1 mRNA and binding activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GM-CSF	GM-CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	predominantly	predominantly	ADV	RB	_	_	_	_	_
34	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
35	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
41	continuously	continuously	ADV	RB	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	Epo.	Epo.	PROPN	NNP	Number=Sing	_	_	_	_
47	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-7	-7	NUM	CD	NumType=Card	_	_	_	_
49	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	UT	ut	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	7	7	NUM	CD	NumType=Card	_	_	_	_
54	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
56	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	_
61	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
62	and	and	CCONJ	CC	_	_	_	_	_
63	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
64	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2971
# text = The two lines also expressed comparable levels of Epo-R mRNA while the number of Epo-binding sites on UT-7
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-R	-R	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	while	while	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Epo-	Epo-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2972
# text = Epo cells was one-sixth the number of UT-7 cells (2400 +/- 3 vs. 13,800 +/- 300).
1	Epo	Epo	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	sixth	sixth	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	7	7	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	2400	2400	NUM	CD	NumType=Card	_	_	_	_
16	+/-	+/-	SYM	SYM	_	_	_	_	_
17	3	3	NUM	CD	NumType=Card	_	_	_	_
18	vs.	vs.	NOUN	NNS	Number=Plur	_	_	_	_
19	13,800	13,800	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2973
# text = This difference in the number of binding sites could be due to differences in cell surface (UT-7 cells are 20% smaller than the parental UT-7 cells) or in receptor turnover.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	number	number	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	due	due	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	_
25	smaller	smaller	ADJ	JJR	Degree=Cmp	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
29	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2974
# text = By Northern analysis, UT-7 cells expressed detectable levels of beta- and gamma-globin but not alpha-globin.
1	By	by	ADP	IN	_	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2975
# text = In comparison, UT-7
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2976
# text = Epo cells expressed alpha-globin and higher levels of gamma-globin (5-fold) and beta-globin (from barely to clearly detectable).
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	higher	higher	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	from	from	ADP	IN	_	_	_	_	_
25	barely	barely	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	clearly	clearly	ADV	RB	_	_	_	_	_
28	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2977
# text = Globin chains (alpha, beta and gamma) were clearly detectable by affinity chromatography in UT-7
1	Globin	Globin	ADJ	JJ	Degree=Pos	_	_	_	_
2	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	clearly	clearly	ADV	RB	_	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
15	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2978
# text = Epo but not in UT-7 cells.
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	but	but	CCONJ	CC	_	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2979
# text = The frequency of the cells which expressed beta- and gamma- globin genes in the two cell populations was measured by immunofluorescence with beta- and gamma-specific antibodies.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2980
# text = The number of gamma-positive cells and their fluorescence intensity were higher in UT-7
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
11	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2981
# text = Epo than in UT-7 cells (0 to 17% barely positive cells and 23 to 40% clearly positive cells, respectively), indicating that the increase in globin mRNA observed in UT-7
1	Epo	Epo	ADV	RB	_	_	_	_	_
2	than	than	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	0	0	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	%	%	SYM	NN	Number=Sing	_	_	_	_
13	barely	barely	ADV	RB	_	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	23	23	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	clearly	clearly	ADV	RB	_	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	globin	globin	PROPN	NNP	Number=Sing	_	_	_	_
34	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
35	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2982
# text = Epo is due to both an increase of gene expression per cell and an increase in numbers of cells containing gamma-globin.
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	per	per	ADP	IN	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2983
# text = The levels of GATA-1, Epo-R and globin mRNA expressed were not affected by a 24-hour incubation of either cell line with Epo, GM-CSF or interleukin-3 (IL-3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-R	-R	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	globin	globin	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
22	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	either	either	DET	DT	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	3	3	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2984
# text = (ABSTRACT TRUNCATED AT 400 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	400	400	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2985
# text = Document 003001186 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001186	003001186	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2986
# text = Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	BRLF1	Brlf1	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2987
# text = Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, is a human herpesvirus associated with epithelial cell malignancies (nasopharyngeal carcinoma) as well as B-cell malignancies.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	causative	causative	ADJ	JJ	Degree=Pos	_	_	_	_
11	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
14	mononucleosis	mononucleosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
27	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2988
# text = Understanding how viral latency is disrupted is a central issue in herpesvirus biology.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	how	how	ADV	WRB	PronType=Int	_	_	_	_
3	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
4	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
10	issue	issue	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
13	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2989
# text = Epithelial cells are the major site of lytic EBV replication within the human host, and viral reactivation occurs in EBV-associated nasopharyngeal carcinomas.
1	Epithelial	Epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
18	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
19	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
25	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2990
# text = It is known that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiate the switch from latent to lytic infection in B cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	latent	latent	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2991
# text = Cellular regulation of BZLF1 transcription is therefore thought to play a key role in regulating the stringency of viral latency.
1	Cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BZLF1	BZLF1	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	therefore	therefore	ADV	RB	_	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	stringency	stringency	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2992
# text = Here we show that, unexpectedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latency in an epithelial cell-specific fashion.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	another	another	DET	DT	_	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	BRLF1	BRLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2993
# text = Therefore, the mechanisms leading to disruption of EBV latency appear to be cell-type specific.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
10	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
11	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2994
# text = Document 003001187 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001187	003001187	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2995
# text = Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation [published erratum appears in Biochim Biophys Acta 1995 Dec 27;1264(3):409]
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	hydroxyurea	hydroxyurea	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	K562	K562	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
19	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Biochim	Biochim	PROPN	NNP	Number=Sing	_	_	_	_
22	Biophys	Biophys	PROPN	NNP	Number=Sing	_	_	_	_
23	Acta	Acta	PROPN	NNP	Number=Sing	_	_	_	_
24	1995	1995	NUM	CD	NumType=Card	_	_	_	_
25	Dec	Dec	PROPN	NNP	Number=Sing	_	_	_	_
26	27;1264	27;1264	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	:409	:409	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2996
# text = Hydroxyurea (HU) is an antitumor agent which also induces hemoglobinization during erythroid differentiation.
1	Hydroxyurea	Hydroxyurea	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	antitumor	antitumor	ADJ	JJ	Degree=Pos	_	_	_	_
8	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	hemoglobinization	hemoglobinization	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2997
# text = In addition, HU stimulates the synthesis of fetal hemoglobin in sickle cell anemia patients.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HU	Hu	PRON	PRP	Case=Nom|Person=2|PronType=Prs	_	_	_	_
5	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
10	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	anemia	anemia	ADP	IN	_	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2998
# text = To further understand its mechanism of action, we investigated the effects of HU on regulation of c-jun expression prior to the onset of erythroid differentiation of K562 cells.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HU	Hu	PRON	PRP	Case=Acc|Person=2|PronType=Prs	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	K562	K562	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2999
# text = HU induced a dose-dependent stimulation of c-jun synthesis.
1	HU	Hu	PRON	PRP	Case=Nom|Person=2|PronType=Prs	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3000
# text = The levels of c-jun mRNA was elevated 4 to 7.5-fold by HU within 2 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	7.5	7.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3001
# text = This was followed by a gradual decline to the basal level by 24 h.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	gradual	gradual	ADJ	JJ	Degree=Pos	_	_	_	_
7	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	24	24	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3002
# text = Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the c-jun mRNA.
1	Both	both	DET	DT	_	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	on	on	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	actinomycin	actinomycin	ADJ	JJ	Degree=Pos	_	_	_	_
8	D	D	NOUN	NN	Number=Sing	_	_	_	_
9	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	_
10	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
11	strongly	strongly	ADV	RB	_	_	_	_	_
12	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
15	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	jun	jun	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	ADV	RB	_	_	_	_	_
27	well	well	ADV	RB	Degree=Pos	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	stabilizing	stabilize	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
33	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3003
# text = In addition, the level of jun protein was elevated by 2 to 5-fold within 4 h in HU treated cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
22	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3004
# text = Furthermore, concentrations of HU below 250 microM slightly increased the 5X AP-1/CAT activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
6	below	below	ADV	RB	_	_	_	_	_
7	250	250	NUM	CD	NumType=Card	_	_	_	_
8	microM	microm	PROPN	NNP	Number=Sing	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	5X	5X	PROPN	NNP	Number=Sing	_	_	_	_
13	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3005
# text = These results strongly suggest that HU induces both transcriptional and post-transcription regulation of c-jun during erythroid differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	post	post	X	AFX	_	_	_	_	SpaceAfter=No
12	-transcription	-transcription	NOUN	NN	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3006
# text = Document 003001188 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001188	003001188	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3007
# text = Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
6	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
7	receptors	receptor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3008
# text = Elevation of the levels of circulating immune complexes frequently accompanies HIV-1 infection and is a prognostic indicator of clinical progression from asymptomatic infection to AIDS.
1	Elevation	Elevation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	SCONJ	IN	_	_	_	_	_
6	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	immune	immune	PRON	NN	Number=Sing	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	frequently	frequently	ADV	RB	_	_	_	_	_
10	accompanies	accompany	NOUN	NNS	Number=Plur	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	prognostic	prognostic	ADJ	JJ	Degree=Pos	_	_	_	_
19	indicator	indicator	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
22	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	AIDS	Aid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3009
# text = Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
9	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
10	RI	RI	PROPN	NNP	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
13	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
14	RII	RII	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	IgG	Igg	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
23	-Fc	-Fc	X	GW	_	_	_	_	_
24	gamma	gamma	X	GW	_	_	_	_	_
25	R	R	X	GW	_	_	_	_	_
26	mAb	mAb	X	GW	_	_	_	_	_
27	activates	activate	X	GW	_	_	_	_	_
28	HIV	HIV	X	GW	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	line	line	NOUN	NN	Number=Sing	_	_	_	_
39	BF24	BF24	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
43	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
47	from	from	ADP	IN	_	_	_	_	_
48	HIV	haHive	PROPN	NNP	Number=Sing	_	_	_	_
49	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
51	as	as	SCONJ	IN	_	_	_	_	_
52	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
55	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3010
# text = In THP-1 cells, Fc gamma R cross-linking induced NF-kappa B, which is known to bind to the regulatory region of the long terminal repeat (LTR) of HIV-1 and to activate HIV-1 transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	R	R	PROPN	NNP	Number=Sing	_	_	_	_
10	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
30	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
31	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
42	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3011
# text = Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1-LTR-driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking.
1	Anti-TNF	Anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	anti-IL	anti-il	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
36	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
37	R	R	PROPN	NNP	Number=Sing	_	_	_	_
38	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3012
# text = These results indicate that Fc gamma R can mediate a TNF-alpha-dependent induction of HIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
6	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
7	R	be	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
27	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
38	by	by	SCONJ	IN	_	_	_	_	_
39	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
40	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
41	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3013
# text = Document 003001189 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001189	003001189	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3014
# text = Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA.
1	Adherence	Adherence	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	EGR2	EGR2	NUM	CD	NumType=Card	_	_	_	_
26	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3015
# text = Adherence is an important initial step in the transition of a circulating monocyte to a tissue macrophage.
1	Adherence	Adherence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
6	step	step	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
17	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3016
# text = This differentiation is accompanied by an augmented capacity to generate growth factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3017
# text = We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit (PDGF[B]) and transforming growth factor-beta (TGF-beta).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
5	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	culminating	culminat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
24	profibrotic	profibrotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
44	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-beta	-beta	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3018
# text = After in vitro adherence, human monocytes had a biphasic increase in PDGF(B) mRNA with peaks at 6 h and 13 d.
1	After	after	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	13	13	NUM	CD	NumType=Card	_	_	_	_
25	d	would	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3019
# text = No increase in TGF-beta mRNA was observed.
1	No	no	DET	DT	_	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3020
# text = The 6-h increase in PDGF(B) mRNA was adherence dependent, and in addition, was abrogated when the cytoskeletal integrity was compromised by cytochalasin D.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	h	h	NOUN	NN	Number=Sing	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	when	when	ADV	WRB	PronType=Int	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytoskeletal	cytoskeletal	ADJ	JJ	Degree=Pos	_	_	_	_
25	integrity	integrity	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	compromised	compromise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	cytochalasin	cytochalasin	PROPN	NNP	Number=Sing	_	_	_	_
30	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3021
# text = The 6-h increase in PDGF(B) mRNA was unaltered by adherence in the presence of the monocyte stimulus lipopolysaccharide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	h	h	NOUN	NN	Number=Sing	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	unaltered	unalter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
23	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3022
# text = Adherence to either fibronectin or collagen-coated plastic had little consistent effect on PDGF(B) mRNA accumulation.
1	Adherence	Adherence	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	either	either	CCONJ	CC	_	_	_	_	_
4	fibronectin	fibronectin	VERB	VB	VerbForm=Inf	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	collagen	collagen	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	coated	coate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
12	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3023
# text = The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PDGF	Pdgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	20	20	NUM	CD	NumType=Card	_	_	_	_
30	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
40	at	at	ADP	IN	_	_	_	_	_
41	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	24	24	NUM	CD	NumType=Card	_	_	_	_
44	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3024
# text = The increase in c-jun and EGR2, but not c-fos, mRNA was also abrogated by cytochalasin D.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	cytochalasin	cytochalasin	PROPN	NNP	Number=Sing	_	_	_	_
20	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3025
# text = These observations suggest that adherence results in increases of c-fos, c-jun, EGR2, and PDGF(B) mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	PDGF	Pdgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3026
# text = In addition, the increases in c-jun, EGR2, and PDGF(B) may depend on cytoskeletal rearrangement.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	cytoskeletal	cytoskeletal	ADJ	JJ	Degree=Pos	_	_	_	_
21	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3027
# text = Modulation of these events at the time of adherence offers a mechanism by which differential priming of the cells may be accomplished.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	time	time	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
10	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
16	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	accomplished	accomplish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3028
# text = Document 003001190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001190	003001190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3029
# text = NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB-	kappaB-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	x	x	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Bfl	Bfl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-1/A1	-1/A1	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
19	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
20	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3030
# text = Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	thymus	thymus	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	humoral	humoral	ADJ	JJ	Degree=Pos	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	rescuing	rescue	VERB	VBG	VerbForm=Ger	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3031
# text = Many of the effects of CD40 are believed to be achieved through altered gene expression.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3032
# text = In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	x	x	SYM	SYM	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	A1/	A1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
24	Bfl	Bfl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3033
# text = Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Bfl	Bfl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-1	-1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	x	x	NOUN	NN	Number=Sing	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	also	also	ADV	RB	_	_	_	_	_
38	eliminated	eliminate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	rescue	rescue	VERB	VB	VerbForm=Inf	_	_	_	_
45	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3034
# text = Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation.
1	Within	within	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	x	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3035
# text = Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	x	x	SYM	SYM	_	_	_	_	_
11	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3036
# text = Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
12	proceeds	proceed	NOUN	NNS	Number=Plur	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3037
# text = Document 003001191 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001191	003001191	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3038
# text = Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
5	flow	flow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	HAEC	Haec	PROPN	NNP	Number=Sing	_	_	_	_
9	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3039
# text = We recently reported that prolonged exposure of human aortic endothelial cells (HAEC) to low shear stress flow patterns is associated with a sustained increase in the activated form of the transcriptional regulator nuclear factor-kappaB (NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	prolonged	prolonge	ADJ	JJ	Degree=Pos	_	_	_	_
6	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	HAEC	HAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
20	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	form	form	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
35	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3040
# text = Here we investigate the hypothesis that low shear-induced activation of NF-kappaB is responsible for enhanced expression of vascular cell adhesion molecule (VCAM-1) resulting in augmented endothelial cell-monocyte (EC-Mn) adhesion and that this activation is dependent on intracellular oxidant activity.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
25	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	augmented	augment	ADJ	JJ	Degree=Pos	_	_	_	_
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	that	that	SCONJ	IN	_	_	_	_	_
46	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
52	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3041
# text = Before exposure to low shear (2 dyn/cm2) for 6 h, HAEC were preincubated with or without the antioxidants pyrrolidine dithiocarbamate (PDTC) or N-acetyl-L-cysteine (NAC).
1	Before	before	ADP	IN	_	_	_	_	_
2	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	dyn/	dyn/	SYM	SYM	_	_	_	_	SpaceAfter=No
9	cm2	cm2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	HAEC	Haec	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	without	without	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
23	pyrrolidine	pyrrolidine	PRON	PRP	_	_	_	_	_
24	dithiocarbamate	dithiocarbamate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-L-	-l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3042
# text = PDTC strongly inhibited low shear-induced activation of NF-kappaB, expression of VCAM-1, and EC-Mn adhesion.
1	PDTC	Pdtc	PROPN	NNP	Number=Sing	_	_	_	_
2	strongly	strongly	ADV	RB	_	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3043
# text = Paradoxically, NAC exerted a positive effect on low shear-induced VCAM-1 expression and EC-Mn adhesion and only slightly downregulated NF-kappaB activation.
1	Paradoxically	paradoxically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
4	exerted	exert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
10	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
21	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	only	only	ADV	RB	_	_	_	_	_
24	slightly	slightly	ADV	RB	_	_	_	_	_
25	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3044
# text = However, cytokine-induced NF-kappaB activation and VCAM-1 expression are blocked by both PDTC and NAC.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3045
# text = These data suggest that NF-kappaB plays a key role in low shear-induced VCAM-1 expression and that pathways mediating low shear- and cytokine-induced EC-Mn adhesion may be differentially regulated.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
24	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
26	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	differentially	differentially	ADV	RB	_	_	_	_	_
39	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3046
# text = Document 003001192 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001192	003001192	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3047
# text = The small GTP-binding protein Rho potentiates AP-1 transcription in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	GTP-	Gtp-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
7	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3048
# text = The Rho family of small GTP-binding proteins is involved in the regulation of cytoskeletal structure, gene transcription, specific cell fate development, and transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	GTP-	Gtp-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytoskeletal	cytoskeletal	ADJ	JJ	Degree=Pos	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
24	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3049
# text = We demonstrate in this report that overexpression of an activated form of Rho enhances AP-1 activity in Jurkat T cells in the presence of phorbol myristate acetate (PMA), but activated Rho (V14Rho) has little or no effect on NFAT, Oct-1, and NF-kappaB enhancer element activities under similar conditions.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	form	form	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
14	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
28	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
29	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	no	no	DET	DT	_	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
46	on	on	ADP	IN	_	_	_	_	_
47	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
56	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
57	element	element	NOUN	NN	Number=Sing	_	_	_	_
58	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
59	under	under	ADP	IN	_	_	_	_	_
60	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
61	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3050
# text = Overexpression of a V14Rho construct incapable of membrane localization (CAAX deleted) abolishes PMA-induced AP-1 transcriptional activation.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
6	construct	construct	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	incapable	incapable	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CAAX	CAAX	NOUN	NN	Number=Sing	_	_	_	_
13	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3051
# text = The effect of Rho on AP-1 is independent of the mitogen-activated protein kinase pathway, as a dominant-negative MEK and a MEK inhibitor (PD98059) did not affect Rho-induced AP-1 activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	MEK	Mek	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	MEK	Mek	PROPN	NNP	Number=Sing	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
36	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3052
# text = V14Rho binds strongly to protein kinase Calpha (PKCalpha) in vivo; however, deletion of the CAAX site on V14Rho severely diminished this association.
1	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
3	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	Calpha	Calpha	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PKCalpha	PKCalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CAAX	CAAX	PROPN	NNP	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
25	severely	severely	ADV	RB	_	_	_	_	_
26	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	association	association	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3053
# text = Evidence for a role for PKCalpha as an effector of Rho was obtained by the observation that coexpression of the N-terminal domain of PKCalpha blocked the effects of activated Rho plus PMA on AP-1 transcriptional activity.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	PKCalpha	PKCalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PKCalpha	PKCalpha	PROPN	NNP	Number=Sing	_	_	_	_
26	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
32	plus	plus	CCONJ	CC	_	_	_	_	_
33	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3054
# text = These data suggest that Rho potentiates AP-1 transcription during T-cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rho	Rho	PRON	WP	PronType=Int	_	_	_	_
6	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3055
# text = Document 003001193 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001193	003001193	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3056
# text = Fibrinogen activates NF-kappa B transcription factors in mononuclear phagocytes.
1	Fibrinogen	Fibrinogen	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3057
# text = Adhesion to extracellular matrices is known to modulate leukocyte activation, although the mechanisms are not fully understood.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	matrices	matrice	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	although	although	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	fully	fully	ADV	RB	_	_	_	_	_
18	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3058
# text = Mononuclear phagocytes are exposed to fibrinous provisional matrix throughout migration into inflammatory foci, so this study was undertaken to determine whether fibrinogen triggers activation of NF-kappa B transcription factors.
1	Mononuclear	Mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	fibrinous	fibrinous	VERB	VB	VerbForm=Inf	_	_	_	_
7	provisional	provisional	ADJ	JJ	Degree=Pos	_	_	_	_
8	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
9	throughout	throughout	ADP	IN	_	_	_	_	_
10	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	foci	foci	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	so	so	ADV	RB	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	study	study	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	undertaken	undertake	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
22	whether	whether	SCONJ	IN	_	_	_	_	_
23	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	_
24	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3059
# text = U937 cells differentiated with PMA in nonadherent culture were shown to express two fibrinogen-binding integrins, predominately CD11b/CD18, and to a lesser extent, CD11c/CD18. Cells stimulated with fibrinogen (10-100 microg/ml)/Mn2+ (50 microM) for 2 h were examined by electrophoretic mobility shift assay.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	nonadherent	nonadherent	ADJ	JJ	Degree=Pos	_	_	_	_
8	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	predominately	predominately	ADV	RB	_	_	_	_	_
20	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
26	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD11c/CD18	CD11c/CD18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_
30	Cells	cells	PROPN	NNPS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	100	100	NUM	CD	NumType=Card	_	_	_	_
38	microg/ml)/Mn2+	microg/ml)/mn2+	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	50	50	NUM	CD	NumType=Card	_	_	_	_
41	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	h	h	NOUN	NN	Number=Sing	_	_	_	_
46	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
50	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
51	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
52	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3060
# text = NF-kappa B activation, minimal in unstimulated cells, was substantially up-regulated by fibrinogen.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	substantially	substantially	ADV	RB	_	_	_	_	_
14	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3061
# text = Fibrinogen also caused activation of AP-1, but not SP1 or cAMP response element-binding protein (CREB) factors.
1	Fibrinogen	Fibrinogen	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3062
# text = Blocking mAbs against CD18 and CD11b abrogated fibrinogen-induced NF-kappa B activation.
1	Blocking	Blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
2	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
3	against	against	ADP	IN	_	_	_	_	_
4	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	18	18	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	CD11	CD11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	b	b	NOUN	NN	Number=Sing	_	_	_	_
9	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	fibrinogen	fibrinogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3063
# text = To determine the effects on transcriptional regulation, U937 cells were transfected with a plasmid containing the HIV-1 enhancer (bearing two NF-kappa B sites) coupled to a chloramphenicol acetyltransferase (CAT) reporter.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	U937	U937	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
35	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3064
# text = Cells were subsequently stimulated with 1) PMA for 24 h, inducing CAT activity by 2.6-fold, 2) fibrinogen/Mn2+ for 2 h, inducing CAT activity by 3.2-fold, or 3) costimulation with fibrinogen and PMA, inducing 5.7-fold the CAT activity induced by PMA alone.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	subsequently	subsequently	ADV	RB	_	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	PMA	Pma	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	24	24	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
14	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	2.6	2.6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	Mn2	Mn2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
32	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	3.2	3.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	3	3	X	LS	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
49	5.7	5.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
54	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	by	by	ADP	IN	_	_	_	_	_
57	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
58	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3065
# text = We conclude that contact with fibrinogen-derived proteins may contribute to mononuclear phagocyte activation by signaling through CD11b/CD18, resulting in selective activation of transcriptional regulatory factors, including NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	fibrinogen	fibrinogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	mononuclear	mononuclear	VERB	VB	VerbForm=Inf	_	_	_	_
14	phagocyte	phagocyte	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	CD11b/CD18	CD11b/CD18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3066
# text = Document 003001194 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001194	003001194	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3067
# text = Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
1	Alteration	Alteration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
5	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	separates	separate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3068
# text = The ZEBRA protein from Epstein-Barr virus (EBV) activates a switch from the latent to the lytic expression program of the virus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	latent	latent	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	program	program	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3069
# text = ZEBRA, a member of the bZIP family of DNA-binding proteins, is a transcriptional activator capable of inducing expression from viral lytic cycle promoters.
1	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	member	member	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	bZIP	bZIP	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
25	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3070
# text = It had previously been thought that ZEBRA's capacity to disrupt EBV latency resided primarily in its ability to activate transcription of genes that encode products required for lytic replication.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
13	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
14	resided	reside	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	primarily	primarily	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3071
# text = We generated a point mutant of ZEBRA, Z(S186A), that was not impaired in its ability to activate transcription; however, this mutation abolished its ability to initiate the viral lytic cascade.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	point	point	NOUN	NN	Number=Sing	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	S	s	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	186A	186A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
30	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
37	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3072
# text = The mutant, containing a serine-to-alanine substitution in the DNA-binding domain of the protein, bound to several known ZEBRA-binding sites and activated transcription from reporters bearing known ZEBRA-responsive promoters but did not disrupt latency in EBV-infected cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alanine	alanine	NOUN	NN	Number=Sing	_	_	_	_
11	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	ZEBRA	zebra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	reporters	reporter	NOUN	NNS	Number=Plur	_	_	_	_
35	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
36	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
45	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3073
# text = Therefore, initiation of the EBV lytic cycle by the ZEBRA protein requires a function in addition to transcriptional activation; a change of serine 186 to alanine in the DNA-binding domain of ZEBRA abolished this additional function and uncovered a new role for the ZEBRA protein in disruption of EBV latency.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
7	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	change	change	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
26	186	186	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
37	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
39	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	uncovered	uncover	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
45	role	role	NOUN	NN	Number=Sing	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
49	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
54	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3074
# text = The additional function that is required for initiation of the lytic viral life cycle is likely to require phosphorylation of serine 186 of the ZEBRA protein, which may influence either DNA recognition or transcriptional activation of lytic viral promoters in a chromatinized viral episome.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
13	life	life	NOUN	NN	Number=Sing	_	_	_	_
14	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
22	186	186	NUM	CD	NumType=Card	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
31	either	either	CCONJ	CC	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	chromatinized	chromatinize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
45	episome	episome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3075
# text = Document 003001195 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001195	003001195	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3076
# text = Erythropoietin-dependent induction of hemoglobin synthesis in a cytokine-dependent cell line M-TAT.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hemoglobin	hemoglobin	ADJ	JJ	Degree=Pos	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	M-	M-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	TAT	TAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3077
# text = M-TAT is a cytokine-dependent cell line with the potential to differentiate along the erythroid and megakaryocytic lineages.
1	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3078
# text = We cultured M-TAT cells long term (>
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	term	term	NOUN	NN	Number=Sing	_	_	_	_
9	(>	(>	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3079
# text = 1 year) in the continuous presence of erythropoietin (EPO), granulocyte-macrophage colony-stimulating factor (GM-CSF), or stem cell factor (SCF).
1	1	1	NUM	CD	NumType=Card	_	_	_	_
2	year	year	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	erythropoietin	erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
17	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	SCF	SCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3080
# text = These long term cultures are referred to as M-TAT/EPO, M-TAT/GM-CSF, and M-TAT/SCF cells, respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
3	term	term	NOUN	NN	Number=Sing	_	_	_	_
4	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	TAT	TAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	M-	M-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	TAT/GM	TAT/GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	SCF	Scf	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3081
# text = Hemoglobin concentration and gamma-globin and erythroid delta-aminolevulinate synthase mRNA levels were significantly higher in M-TAT/EPO cells than in M-TAT/GM-CSF cells.
1	Hemoglobin	Hemoglobin	ADP	IN	_	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	delta-	delta-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	aminolevulinate	aminolevulinate	ADJ	JJ	Degree=Pos	_	_	_	_
11	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	TAT	TAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	TAT/GM	TAT/GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3082
# text = When the supplemented cytokine was switched from GM-CSF to EPO, hemoglobin synthesis in M-TAT/GM-CSF cells increased rapidly (within 5 h), and the level of GATA-1 mRNA increased.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	switched	switch	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	hemoglobin	hemoglobin	ADP	IN	_	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	TAT/GM	TAT/GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	rapidly	rapidly	ADV	RB	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	within	within	ADP	IN	_	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
38	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3083
# text = In contrast, the addition of GM-CSF to the M-TAT/EPO cell culture decreased the amount of hemoglobin, even in the presence of EPO, indicating that the EPO signal for erythroid differentiation is suppressed by GM-CSF.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	M-	m-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	TAT	TAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
18	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
35	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3084
# text = Thus, erythroid development of M-TAT cells is promoted by EPO and suppressed by GM-CSF.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3085
# text = These results support the hypothesis that EPO actively influences the programming of gene expression required for erythroid progenitor cell differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
8	actively	actively	ADV	RB	_	_	_	_	_
9	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	programming	programming	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3086
# text = Document 003001196 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001196	003001196	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3087
# text = Transcription factor NF-kappaB regulation of renal fibrosis during ureteral obstruction.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
9	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	ureteral	ureteral	ADJ	JJ	Degree=Pos	_	_	_	_
12	obstruction	obstruction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3088
# text = Irrespective of the etiology, many kidney diseases result in inflammation and fibrosis of the tubulointerstitium, with the subsequent loss of renal function.
1	Irrespective	irrespective	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
7	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
8	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
9	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	tubulointerstitium	tubulointerstitium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
21	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3089
# text = To initiate any disease process or for any disease process to progress, there must be changes in the transcription of genes within the affected tissue.
1	To	to	PART	TO	_	_	_	_	_
2	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
5	process	process	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	any	any	DET	DT	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
10	process	process	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	progress	progress	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	there	there	PRON	EX	_	_	_	_	_
15	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	VERB	VB	VerbForm=Inf	_	_	_	_
17	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3090
# text = The nuclear factor-kappa B (NF-kappaB) family of transcription factors regulates genes involved in inflammation, cell proliferation, and cell differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3091
# text = This review discusses the NF-kappaB transcription factor family in general and the association of NF-kappaB activation with cellular/molecular events of renal inflammation and fibrosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	review	review	NOUN	NN	Number=Sing	_	_	_	_
3	discusses	discuss	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
25	events	event	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
28	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3092
# text = Document 003001197 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001197	003001197	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3093
# text = Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3094
# text = Erythropoietin (Epo), the primary regulator of the production of erythroid cells, acts by binding to a cell surface receptor (EpoR) on erythroid progenitors.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
29	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3095
# text = We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5' flanking region of the human EpoR gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
7	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	_
22	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	EpoR	Epor	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3096
# text = In erythroid cells most of the transcription activity was contained in a 150 bp promoter fragment with binding sites for transcription factors AP2, Sp1 and the erythroid-specific GATA-1.
1	In	in	ADP	IN	_	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	150	150	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	SCONJ	IN	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	AP2	AP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3097
# text = The 150 bp hEpoR promoter exhibited high and low activity in erythroid OCIM1 and K562 cells, respectively, reflecting the high and low levels of constitutive hEpoR expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	150	150	NUM	CD	NumType=Card	_	_	_	_
3	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
4	hEpoR	hepor	CCONJ	CC	_	_	_	_	_
5	promoter	promoter	ADV	RB	_	_	_	_	_
6	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroid	erythroid	PROPN	NNP	Number=Sing	_	_	_	_
13	OCIM1	OCIM1	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	K562	K562	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
28	hEpoR	hepor	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3098
# text = The GATA-1 and Sp1 binding sites in this promoter lacking a TATA sequence were necessary for a high level of transcription activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3099
# text = Protein-DNA binding studies suggested that Sp1 and two other CCGCCC binding proteins from erythroid and non-erythroid cells could bind to the Sp1 binding motif.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	CCGCCC	Ccgccc	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
21	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3100
# text = By increasing GATA-1 levels via co-transfection, we were able to transactivate the hEpoR promoter in K562 cells and non-erythroid cells, but not in the highly active OCIM1 cells, although GATA-1 mRNA levels were comparable in OCIM1 and K562.
1	By	by	SCONJ	IN	_	_	_	_	_
2	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	via	via	ADP	IN	_	_	_	_	_
8	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	hEpoR	hepor	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	K562	K562	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	highly	highly	ADV	RB	_	_	_	_	_
30	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
31	OCIM1	Ocim1	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	although	although	SCONJ	IN	_	_	_	_	_
35	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	OCIM1	Ocim1	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	K562	k562	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3101
# text = Interestingly, when we mutated the Sp1 site, resulting in a marked decrease in hEpoR promoter activity, we could restore transactivation by increasing GATA-1 levels in OCIM1 cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	mutated	mutate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	hEpoR	hepor	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
22	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
23	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	SCONJ	IN	_	_	_	_	_
25	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
26	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	OCIM1	OCIM1	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3102
# text = These data suggest that while GATA-1 can transactivate the EpoR promoter, the level of hEpoR gene expression does not depend on GATA-1 alone.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	while	while	SCONJ	IN	_	_	_	_	_
6	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	hEpoR	hepor	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3103
# text = Rather, hEpoR transcription activity depends on coordination between Sp1 and GATA-1 with other cell-specific factors, including possibly other Sp1-like binding proteins, to provide high level, tissue-specific expression.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hEpoR	hepor	CCONJ	CC	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	possibly	possibly	ADV	RB	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	like	like	SCONJ	IN	_	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
33	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3104
# text = Document 003001198 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001198	003001198	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3105
# text = Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes.
1	Alcohol	alcohol	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3106
# text = Acute ethanol exposure has the capacity to modulate immune functions, particularly, to down regulate monocyte production of inflammatory cytokines.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
3	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	particularly	particularly	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	down	down	ADV	RB	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3107
# text = However, the intracellular mechanisms for these effects of ethanol are yet to be understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ethanol	ethanol	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	yet	yet	ADV	RB	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3108
# text = Considering that nuclear regulatory factor-kappa beta (NF-kappa B)/Rel is a common regulatory element of the promoter region of the inflammatory cytokine genes, herein, we tested the hypothesis that acute ethanol affects NF-kappa B activation in human monocytes.
1	Considering	consider	VERB	VBG	VerbForm=Ger	_	_	_	_
2	that	that	SCONJ	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	herein	herein	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
35	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	acute	acute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
41	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
42	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
49	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3109
# text = Adherence-isolated monocytes showed constitutive DNA binding activity of NF-kappa B.
1	Adherence	Adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3110
# text = A clinically relevant dose (25 mM) of acute ethanol treatment in vitro increased NF-kappa B binding activity in monocytes with a preferential induction of the inhibitory, p50/p50, NF-kappa B/Rel homodimer, and resulted in no induction of the p65/p50 heterodimer.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	clinically	clinically	ADV	RB	_	_	_	_	_
3	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	25	25	NUM	CD	NumType=Card	_	_	_	_
7	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	preferential	preferential	ADJ	JJ	Degree=Pos	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
42	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	no	no	DET	DT	_	_	_	_	_
48	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	p65/	p65/	SYM	SYM	_	_	_	_	SpaceAfter=No
52	p50	p50	NUM	CD	NumType=Card	_	_	_	_
53	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3111
# text = In contrast, lipopolysaccharide stimulation primarily induced the p65/p50 heterodimer that has been shown to result in gene activation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	primarily	primarily	ADV	RB	_	_	_	_	_
7	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	_
12	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3112
# text = Thus, such unique activation of the inhibitory p50/p50 homodimer by acute ethanol treatment may result in inhibition rather than activation of NF-kappa B-regulated inflammatory cytokine genes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
4	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
9	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3113
# text = Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	physiologically	physiologically	ADV	RB	_	_	_	_	_
8	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	ethanol	ethanol	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	by	by	SCONJ	IN	_	_	_	_	_
36	disrupting	disrupting	VERB	VBG	VerbForm=Ger	_	_	_	_
37	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3114
# text = Document 003001199 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001199	003001199	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3115
# text = Signal transduction pathways triggered by the FcepsilonRIIb receptor (CD23) in human monocytes lead to nuclear factor-kappaB activation.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	FcepsilonRIIb	FcepsilonRIIb	PROPN	NNP	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3116
# text = BACKGROUND:
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3117
# text = Alveolar macrophages play a key role in the initiation of the inflammatory reaction of allergic asthma.
1	Alveolar	Alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
16	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3118
# text = Alveolar macrophages and peripheral blood monocytes are activated when IgE/allergen immune complexes bind to the CD23 receptor, which leads to the production of inflammatory cytokines.
1	Alveolar	Alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	allergen	allergen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	immune	immune	PRON	PRP	_	_	_	_	_
14	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3119
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3120
# text = We sought to investigate the molecular mechanisms regulating this early inflammatory response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3121
# text = We have focused on the study of the signal transduction pathways triggered by CD23 in human monocytes and the promonocytic cell line U937.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
12	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3122
# text = METHODS: CD23 was cross-linked in human monocytes and U937 cells with IgE immune complexes.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	cross	cross	ADV	RB	_	_	_	_	SpaceAfter=No
6	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
15	immune	immune	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3123
# text = Surface expression of CD23 was determined by FACS analysis.
1	Surface	surface	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	FACS	FACS	ADJ	JJ	Degree=Pos	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3124
# text = Transcription factor activation and gene transcription were studied by gel-shift assays and Northern blot analysis, respectively.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
13	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
16	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3125
# text = IkappaBalpha phosphorylation and degradation was analyzed by Western blot.
1	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
9	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3126
# text = RESULTS: Nuclear factor (NF)-kappaB is the main transcription factor involved in the gene activation that follows CD23 cross-linking in monocytes.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	follows	follow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
23	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3127
# text = CD23-induced NF-kappaB is a heterodimer composed of p65/p50 subunits.
1	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
9	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p65/	p65/	SYM	SYM	_	_	_	_	SpaceAfter=No
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3128
# text = NF-kappaB nuclear translocation is secondary to the phosphorylation and subsequent degradation of the NF-kappaB inhibitory molecule IkappaBalpha.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
20	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
21	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3129
# text = Tyrosine kinase-dependent, and not protein kinase C-dependent, pathways mediate CD23-triggered NF-kappaB activation but do not participate in the direct phosphorylation of IkappaBalpha.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	CD23	CD23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3130
# text = IkappaBalpha degradation and NF-kappaB nuclear translocation correlate with transcriptional activation of the inflammatory cytokines TNF-alpha and IL-1beta.
1	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
17	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3131
# text = CONCLUSIONS: NF-kappaB is the main transcription factor involved in the signal transduction pathway of CD23 in monocytes.
1	CONCLUSIONS	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3132
# text = Document 003001200 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001200	003001200	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3133
# text = Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
19	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
22	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	gld	gld	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3134
# text = We previously identified a Fas ligand regulatory element (FLRE) in the Fas ligand (fasL) promoter that binds
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Fas	Fas	PROPN	NNPS	Number=Plur	_	_	_	_
6	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FLRE	FLRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Fas	Fas	PROPN	NNPS	Number=Plur	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_

# sent_id = 3135
# text = Egr family proteins and demonstrated that Egr-3 (PILOT) but not Egr-1 (NGFI-A, Krox-24, Tis-8, and Zif-268) induces transcription of fasL.
1	Egr	Egr	ADJ	JJ	Degree=Pos	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-3	-3	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PILOT	Pilot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	Egr	Egr	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NGFI	Ngfi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Krox	Krox	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	24	24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Tis	tis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Zif	Zif	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	268	268	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3136
# text = The aberrant CD4(-)CD8(-)
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aberrant	aberrant	NOUN	NN	Number=Sing	_	_	_	_
3	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
6	CD8	Cd8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(-)	(-)	PUNCT	.	_	_	_	_	_

# sent_id = 3137
# text = T cells from lpr/lpr and gld/gld mice, which have mutations in the genes encoding Fas and FasL, respectively, have an activated phenotype and constitutively express high levels of fasL mRNA, prompting us to ask what role if any the FLRE and Egr family proteins have in this aberrant expression of fasL.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	lpr/	lpr/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
5	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	gld	gld	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	gld	gld	NOUN	NN	Number=Sing	_	_	_	_
10	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	constitutively	constitutively	ADV	RB	_	_	_	_	_
31	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	fasL	fasL	PROPN	NNP	Number=Sing	_	_	_	_
36	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	prompting	prompt	VERB	VBG	VerbForm=Ger	_	_	_	_
39	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	ask	ask	VERB	VB	VerbForm=Inf	_	_	_	_
42	what	what	DET	WDT	PronType=Int	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	if	if	SCONJ	IN	_	_	_	_	_
45	any	any	DET	DT	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	FLRE	Flre	ADJ	JJ	Degree=Pos	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Egr	Egr	ADJ	JJ	Degree=Pos	_	_	_	_
50	family	family	NOUN	NN	Number=Sing	_	_	_	_
51	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
52	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
55	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3138
# text = Unstimulated MRL-lpr/lpr and C3H-gld/gld CD4(-)CD8(-)
1	Unstimulated	Unstimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	MRL	Mrl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	C3H-gld/gld	C3H-gld/gld	PROPN	NNP	Number=Sing	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
11	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(-)	(-)	PUNCT	.	_	_	_	_	_

# sent_id = 3139
# text = T cells constitutively contained high levels of two proteins that bound to the FLRE.
1	T	t	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	FLRE	Flre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3140
# text = Supershift analysis revealed these proteins to be Egr-1 and Egr-2 (Krox-20); Egr-3 was not detected.
1	Supershift	Supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	analysis	analysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-2	-2	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Krox	Krox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-3	-3	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3141
# text = Activation of normal lymph node cells resulted in increased expression of Egr-1, -2, and -3.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
5	node	node	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3142
# text = As with egr-3, expression of egr-2 was blocked by cyclosporin A.
1	As	as	ADP	IN	_	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-2	-2	NUM	CD	NumType=Card	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3143
# text = Although overexpressed Egr-1 was ineffective, overexpressed Egr-2 was as potent as Egr-3 in inducing fasL promoter-dependent reporter constructs in T cell hybridomas and HeLa cells, and both up-regulated endogenous fasL mRNA in HeLa cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	overexpressed	overexpress	ADJ	JJ	Degree=Pos	_	_	_	_
9	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-3	-3	NUM	CD	NumType=Card	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
20	fasL	fasl	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
25	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
29	hybridomas	hybridoma	PROPN	NNPS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	both	both	ADV	RB	_	_	_	_	_
36	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
40	fasL	fasL	PROPN	NNP	Number=Sing	_	_	_	_
41	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3144
# text = FasL-dependent reporter constructs in MRL-lpr/lpr and C3H-gld/gld CD4(-)CD8(-)
1	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	MRL	MRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lpr/lpr	lpr/lpr	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	C3H-gld/	C3H-gld/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	gld	gld	NOUN	NN	Number=Sing	_	_	_	_
13	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
15	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(-)	(-)	PUNCT	.	_	_	_	_	_

# sent_id = 3145
# text = T cells were constitutively active, and this activity was largely prevented by mutation of the critical Egr family binding element.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	largely	largely	ADV	RB	_	_	_	_	_
12	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3146
# text = Thus, Egr-2, in addition to Egr-3, regulates FasL expression in activated normal T cells, and Egr-2 is likely to play a direct role in aberrant fasL up-regulation in lpr/lpr and gld/gld CD4(-)CD8(-) T cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
34	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	_
35	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	lpr/lpr	lpr/lpr	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	gld/gld	gld/gld	ADJ	JJ	Degree=Pos	_	_	_	_
42	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
44	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	-)	-)	PUNCT	.	_	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3147
# text = Document 003001201 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001201	003001201	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3148
# text = Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	messenger	messenger	ADV	RBR	_	_	_	_	_
8	ribonucleic	ribonucleic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemic	leukemic	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3149
# text = Cortivazol is a phenylpyrazolo glucocorticoid of high potency and unusual structure.
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	phenylpyrazolo	phenylpyrazolo	NOUN	NN	Number=Sing	_	_	_	_
5	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
11	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3150
# text = In both wild-type and highly dexamethasone(dex)-resistant clones of the human leukemic cell line CEM, exposure to cortivazol leads to cell death.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	highly	highly	ADV	RB	_	_	_	_	_
8	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	dex	dex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	cortivazol	cortivazol	VERB	VB	VerbForm=Inf	_	_	_	_
26	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
29	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3151
# text = It has been shown recently that in wild-type CEM cells but not in a dex-resistant, glucocorticoid receptor(GR)-defective clone ICR-27 TK-3, dex induces GR mRNA.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	recently	recently	ADV	RB	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	dex	dex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-resistant	-resistant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
27	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
28	ICR	Icr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	27	27	NUM	CD	NumType=Card	_	_	_	_
31	TK	TK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	dex	dex	NOUN	NN	Number=Sing	_	_	_	_
36	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
37	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
38	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3152
# text = To test the hypothesis that cortivazol acts in dex-resistant cells by making use of the residual GR found there, wild-type and dex-resistant clones were treated with various concentrations of cortivazol and induction of GR mRNA was studied.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	cortivazol	cortivazol	ADJ	JJ	Degree=Pos	_	_	_	_
7	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
13	use	use	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	residual	residual	ADJ	JJ	Degree=Pos	_	_	_	_
17	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
18	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	there	there	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
26	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
31	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cortivazol	cortivazol	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
38	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3153
# text = Cortivazol significantly induced GR mRNA in the normal CEM-C7 as well as in two classes of dex-resistant clones, although the dex-resistant clones needed at least 10 times more cortivazol than the normal cells for significant GR mRNA induction.
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	significantly	significantly	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	CEM	cem	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	C7	C7	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
20	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	although	although	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
25	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
26	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADV	RB	_	_	_	_	_
28	least	least	ADV	RBS	Degree=Sup	_	_	_	_
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	times	time	NOUN	NNS	Number=Plur	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	cortivazol	cortivazol	NOUN	NN	Number=Sing	_	_	_	_
33	than	than	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
39	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
40	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3154
# text = Increased levels of GR mRNA were noticed as early as 3 h after treatment.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	noticed	notice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	as	as	ADV	RB	_	_	_	_	_
9	early	early	ADV	RB	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3155
# text = A general correlation between induction of GR mRNA and lysis of the normal and dex-resistant cells was found.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dex	dex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3156
# text = Positive induction of GR mRNA might be one of the earliest crucial steps in the lysis of normal and dex-resistant CEM cells, or might serve as a marker for the process.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
12	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
13	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
21	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
26	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3157
# text = However, the lysis pathway in the dex-resistant cells is defective in that dex-resistant clones needed significantly more cortivazol than the normal cells for lysis of the cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	dex-	dex-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	dex-	dex-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
17	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
18	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	cortivazol	cortivazol	ADJ	JJ	Degree=Pos	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3158
# text = Document 003001202 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001202	003001202	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3159
# text = Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PILOT	Pilot	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	cyclosporin	cyclosporin	VERB	VB	VerbForm=Inf	_	_	_	_
16	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	sensitive	sensitive	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3160
# text = Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).
1	Few	few	ADJ	JJ	Degree=Pos	_	_	_	_
2	known	know	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
33	myristic	myristic	ADJ	JJ	Degree=Pos	_	_	_	_
34	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	only	only	ADV	RB	_	_	_	_	_
51	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
52	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
53	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
54	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
55	fully	fully	ADV	RB	_	_	_	_	_
56	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
59	A	A	PROPN	NNP	Number=Sing	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3161
# text = We have identified a putative transcription factor, designated PILOT, with an identical dual signal requirement for expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	PILOT	Pilot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
15	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3162
# text = Induction of the PILOT gene is detectable in human T cells 20 min following activation in the presence of cycloheximide and is fully suppressed by CyA.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PI	PI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	LOT	lot	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	20	20	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	fully	fully	ADV	RB	_	_	_	_	_
25	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3163
# text = The PILOT protein has a calculated M(r) of 42.6 kDa and contains three zinc fingers of the C2H2-type at the carboxyl-terminus which are highly homologous to the zinc finger regions of the transcription factors EGR1, EGR2, and pAT 133.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PI	pi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	LOT	Lot	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	calculated	calculate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	42.6	42.6	NUM	CD	NumType=Card	_	_	_	_
14	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	three	three	NUM	CD	NumType=Card	_	_	_	_
18	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
19	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	C2	C2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	highly	highly	ADV	RB	_	_	_	_	_
34	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
38	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
39	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
43	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
44	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	EGR2	EGR2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	pAT	pAT	NOUN	NN	Number=Sing	_	_	_	_
50	133	133	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3164
# text = In contrast to T cells, in fibroblasts PILOT gene expression requires only one signal (PMA) and is not affected by CyA.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
9	PI	PI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	LOT	LOT	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3165
# text = This observation directly demonstrates the existence of a Ca2+ signal-dependent regulatory element obligatory for expression of some genes in T cells but not in fibroblasts.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	directly	directly	ADV	RB	_	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	obligatory	obligatory	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3166
# text = This differential expression model will be valuable in the dissection of the dual signal pathway in T cells and the effects of CyA upon it.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	valuable	valuable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3167
# text = Document 003001203 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001203	003001203	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3168
# text = ras protein activity is essential for T-cell antigen receptor signal transduction.
1	ras	ra	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3169
# text = In a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with the lymphokine interleukin-1.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	agonism	agonism	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3170
# text = Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbol esters in combination with calcium mobilization by an ionophore.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	suboptimal	suboptimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
24	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3171
# text = In cotransfection experiments, oncogenic rats obviated the need for PKC stimulation but did not replace either the calcium signal or interleukin-1.
1	In	in	ADP	IN	_	_	_	_	_
2	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
7	obviated	obviate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	need	need	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	replace	replace	VERB	VB	VerbForm=Inf	_	_	_	_
17	either	either	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3172
# text = Activated ras expression also replaced the requirement for PKC stimulation in activation of the T-cell transcription factor NF-AT.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	replaced	replace	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3173
# text = A dominant inhibitory ras mutant specifically blocked antigen receptor agonism, indicating that ras activity is required for antigen receptor signaling.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
4	ras	ra	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
6	specifically	specifically	ADV	RB	_	_	_	_	_
7	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	agonism	agonism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	ras	ras	NOUN	NNS	Number=Plur	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	antigen	antigen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3174
# text = In addition, an inhibitor of PKC blocked both activated ras and phorbol ester stimulation, suggesting a role for ras upstream of PKC.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
8	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
14	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
22	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3175
# text = Document 003001204 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001204	003001204	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3176
# text = Differential induction of interferon (IFN)-inducible protein 10 following differentiation of a monocyte, macrophage cell lineage is related to the changes of nuclear proteins bound to IFN stimulus response element and kappaB sites.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	10	10	NUM	CD	NumType=Card	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
29	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	IFN	IFN	VERB	VB	VerbForm=Inf	_	_	_	_
32	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	element	element	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
37	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3177
# text = We examined chemokine gene expression following the differentiation of a monocyte, macrophage cell lineage.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3178
# text = The human monoblastic cell line, U937 was differentiated to macrophages by the treatment with either phorbol 12-myristate 13-acetate (PMA), retinoic acid (RA), or vitamin D3 (VitD3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	either	either	DET	DT	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
29	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
36	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3179
# text = The gene expression of interferon (IFN)-inducible protein 10 (IP-10) (a CXC chemokine) was markedly augmented by the IFNgamma treatment in PMA- or RA-differentiated U937 cells, but only marginally in undifferentiated or VitD3-treated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	CXC	Cxc	NOUN	NN	Number=Sing	_	_	_	_
21	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	markedly	markedly	ADV	RB	_	_	_	_	_
25	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
29	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	only	only	ADV	RB	_	_	_	_	_
42	marginally	marginally	ADV	RB	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3180
# text = In contrast, another inducible gene expression of monocyte chemotactic protein-1 (a CC chemokine) and the activation of the transcriptional factor (FcRFgamma) bound to the gamma response region were similarly or less abundantly induced by IFNgamma treatment in PMA- or RA-differentiated U937 cells, indicating that increased IP-10 mRNA induction was not due to the augmented ability of the cells to respond to the presence of IFNgamma.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	another	another	DET	DT	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
10	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	CC	cc	NOUN	NN	Number=Sing	_	_	_	_
17	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	FcRFgamma	FcRFgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	region	region	NOUN	NN	Number=Sing	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	similarly	similarly	ADV	RB	_	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
39	abundantly	abundantly	ADV	RB	_	_	_	_	_
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
43	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
55	that	that	SCONJ	IN	_	_	_	_	_
56	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	10	10	NUM	CD	NumType=Card	_	_	_	_
60	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
61	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
62	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
63	not	not	PART	RB	_	_	_	_	_
64	due	due	ADP	IN	_	_	_	_	_
65	to	to	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	augmented	augmented	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
72	to	to	PART	TO	_	_	_	_	_
73	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
74	to	to	ADP	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
77	of	of	ADP	IN	_	_	_	_	_
78	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3181
# text = Increased expression of IFNgamma-induced IP-10 mRNA following the differentiation of U937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to IFN stimulus response element (ISRE) and kB sites, suggesting that these nuclear proteins may determine the IP-10 mRNA inducibility by IFNgamma.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	U937	U937	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	largely	largely	ADV	RB	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	IFN	Ifn	VERB	VB	VerbForm=Inf	_	_	_	_
41	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	_
42	response	response	NOUN	NN	Number=Sing	_	_	_	_
43	element	element	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	ISRE	ISRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	kB	kb	NOUN	NN	Number=Sing	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
52	that	that	SCONJ	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
55	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
56	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
57	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
61	10	10	NUM	CD	NumType=Card	_	_	_	_
62	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
63	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
64	by	by	ADP	IN	_	_	_	_	_
65	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3182
# text = Document 003001205 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001205	003001205	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3183
# text = Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.
1	Cloning	Cloning	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
29	polymerases	polymerase	NOUN	NNS	Number=Plur	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3184
# text = The proximal sequence element (PSE)-binding transcription factor (PTF), which binds the PSE of both RNA polymerase II- and RNA polymerase III-transcribed mammalian small nuclear RNA (snRNA) genes, is essential for their transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PSE	PSE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	PSE	Pse	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
23	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
28	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
29	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
33	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	snRNA	snRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3185
# text = We previously reported the purification of human PTF, a complex of four subunits, and the molecular cloning and characterization of PTF gamma and delta subunits.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	PTF	PTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	four	four	NUM	CD	NumType=Card	_	_	_	_
14	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	PTF	PTF	NOUN	NN	Number=Sing	_	_	_	_
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
27	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3186
# text = Here we describe the isolation and expression of a cDNA encoding PTF beta, as well as functional studies using anti-PTF beta antibodies.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
11	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	PTF	Ptf	PROPN	NNP	Number=Sing	_	_	_	_
13	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	anti-PTF	anti-ptf	ADJ	JJ	Degree=Pos	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3187
# text = Native PTF beta, in either protein fractions or a PTF-Oct-1-DNA complex, can be recognized by polyclonal antibodies raised against recombinant PTF beta.
1	Native	native	ADJ	JJ	Degree=Pos	_	_	_	_
2	PTF	PTF	NOUN	NN	Number=Sing	_	_	_	_
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	either	either	DET	DT	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	PTF-	Ptf-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
23	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
24	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	against	against	ADP	IN	_	_	_	_	_
26	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
27	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
28	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3188
# text = Immunodepletion studies show that PTF beta is required for transcription of both classes of snRNA genes in vitro.
1	Immunodepletion	Immunodepletion	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
6	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	classes	classe	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3189
# text = In addition, immunoprecipitation analyses demonstrate that substantial and similar molar amounts of TATA-binding protein (TBP) and TFIIIB90 can weakly associate with PTF at low salt conditions, but this association is dramatically reduced at high salt concentrations.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	molar	molar	ADJ	JJ	Degree=Pos	_	_	_	_
12	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TBP	TBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	TFIIIB90	TFIIIB90	PROPN	NNP	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	weakly	weakly	ADV	RB	_	_	_	_	_
25	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	PTF	Ptf	NOUN	NN	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
30	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
31	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	association	association	NOUN	NN	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	dramatically	dramatically	ADV	RB	_	_	_	_	_
38	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	at	at	ADP	IN	_	_	_	_	_
40	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
41	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
42	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3190
# text = Along with our previous demonstration of both physical interactions between PTF gamma/PTF delta and TBP and the involvement of TFIIIB90 in the transcription of class III snRNA genes, these results are consistent with the notion that a TBP-containing complex related to TFIIIB is required for the transcription of class III snRNA genes, and acts through weak interaction with the four-subunit PTF.
1	Along	along	ADP	IN	_	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
5	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
9	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
12	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
15	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TFIIIB90	TFIIIB90	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	class	class	NOUN	NN	Number=Sing	_	_	_	_
28	III	Iii	NUM	CD	NumType=Card	_	_	_	_
29	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	results	result	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
44	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
45	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	TFIIIB	TFIIIB	PROPN	NNP	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	for	for	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	class	class	NOUN	NN	Number=Sing	_	_	_	_
55	III	iii	NUM	CD	NumType=Card	_	_	_	_
56	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
57	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	through	through	ADP	IN	_	_	_	_	_
62	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
63	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
64	with	with	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	four-subunit	four-subunit	ADJ	JJ	Degree=Pos	_	_	_	_
67	PTF	Ptf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3191
# text = Document 003001206 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001206	003001206	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3192
# text = Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.
1	Tandem	tandem	PROPN	NNP	Number=Sing	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3193
# text = A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
14	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	11	11	NUM	CD	NumType=Card	_	_	_	_
16	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3194
# text = 5' to the human epsilon-globin gene within the dominant control or locus-activating region.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3195
# text = This enhancer is inducible in K562 human erythroleukemia cells, increasing linked gamma-globin promoter/luciferase gene expression to 170-fold over an enhancerless construct.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	K562	K562	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
12	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	170	170	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	over	over	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	enhancerless	enhancerless	ADJ	JJ	Degree=Pos	_	_	_	_
28	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3196
# text = The enhancer consists of tandem AP-1-binding sites, phased 10 bp apart, which are both required for full activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	phased	phase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	apart	apart	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	both	both	ADV	RB	_	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3197
# text = DNA-protein binding assays with nuclear extracts from induced cells demonstrate a high molecular weight complex on the enhancer.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	molecular	molecular	NOUN	NN	Number=Sing	_	_	_	_
15	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3198
# text = The formation of this complex also requires both AP-1 sites and correlates with maximal enhancer activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3199
# text = Induction of the enhancer may have a role in the increase in globin gene transcription that characterizes erythroid maturation.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	characterizes	characterize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3200
# text = Enhancer activity appears to be mediated by the binding of a complex of proteins from the jun and fos families to tandem AP-1 consensus sequences.
1	Enhancer	Enhancer	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	families	family	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	tandem	tandem	VERB	VB	VerbForm=Inf	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
27	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3201
# text = Document 003001207 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001207	003001207	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3202
# text = Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
10	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	ADV	RB	_	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
20	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3203
# text = Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
11	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	although	although	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
29	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
30	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3204
# text = In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
12	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
19	B	B	X	LS	_	_	_	_	_
20	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3205
# text = Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calyculin	calyculin	NOUN	NN	Number=Sing	_	_	_	_
22	A	a	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
25	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
28	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	PP	pp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	X	LS	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	type	type	NOUN	NN	Number=Sing	_	_	_	_
41	2A	2a	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PP	pp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
54	kappa	kappa	X	GW	_	_	_	_	_
55	B	benefit	X	GW	_	_	_	_	_
56	alpha	alpha	X	GW	_	_	_	_	_
57	even	even	ADV	RB	_	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	any	any	DET	DT	_	_	_	_	_
63	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
64	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3206
# text = This action of the phosphatase inhibitors, which is associated with the activation of the RelA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	action	action	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	RelA.	RelA.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 3207
# text = p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha).
1	p50	p50	NUM	CD	NumType=Card	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	X	GW	_	_	_	_	_
20	B	b	X	GW	_	_	_	_	_
21	alpha	alpha	X	GW	_	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3208
# text = Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	calyculin	calyculin	PROPN	NNP	Number=Sing	_	_	_	_
11	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	that	that	ADV	WRB	PronType=Dem	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	PP	pp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	A	a	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
42	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
48	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
49	B	b	PROPN	NNP	Number=Sing	_	_	_	_
50	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
51	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	by	by	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	two	two	NUM	CD	NumType=Card	_	_	_	_
55	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
56	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3209
# text = However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	B	X	LS	_	_	_	_	_
8	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3210
# text = We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	calyculin	calyculin	NOUN	NN	Number=Sing	_	_	_	_
11	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
19	exhibits	exhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
24	sensitivities	sensitivity	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
28	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3211
# text = Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	both	both	DET	PDT	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	PP	pp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	opposing	opposing	NOUN	NN	Number=Sing	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	kappa	kappa	X	GW	_	_	_	_	_
38	B	b	X	GW	_	_	_	_	_
39	alpha	alpha	X	GW	_	_	_	_	_
40	for	for	X	GW	_	_	_	_	_
41	proteasome	proteasome	X	GW	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3212
# text = Document 003001208 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001208	003001208	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3213
# text = LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent.
1	LPS	Lps	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	release	release	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	protein	protein	ADJ	JJ	Degree=Pos	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	c	X	GW	_	_	_	_	_
25	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3214
# text = BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is an important mediator of septic shock.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Tumor	tumor	PROPN	NNP	Number=Sing	_	_	_	_
4	necrosis	necrosis	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
18	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3215
# text = Endotoxin (LPS) signal transduction in human monocytes leads to activation of nuclear factor-kappa B (NF-kappaB) and TNF-alpha release.
1	Endotoxin	Endotoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
6	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3216
# text = Previous studies have implicated activation of both protein kinase C (PKC) and protein tyrosine kinases (PTK) in LPS-induced NF-kappaB activation and TNF-alpha production.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3217
# text = We hypothesized that inhibition of either PKC or PTK would decrease LPS-induced NF-kappaB DNA binding and TNF-alpha release in human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	_
10	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
11	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
12	LPS	LPS	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3218
# text = MATERIALS AND METHODS: Human monocytes were stimulated with PMA (50 ng/ml) alone or LPS (100 ng/ml) with and without a nonspecific serine/threonine protein kinase inhibitor staurosporine (Stauro), a specific pan-PKC inhibitor bisindolylmaleimide (Bis), or an inhibitor of PTK genistein (Gen).
1	MATERIALS	material	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	50	50	NUM	CD	NumType=Card	_	_	_	_
13	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	100	100	NUM	CD	NumType=Card	_	_	_	_
22	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	without	without	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
30	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
35	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
36	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	Stauro	Stauro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
43	pan	pan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
46	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
47	bisindolylmaleimide	bisindolylmaleimide	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	Bis	Bis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	or	or	CCONJ	CC	_	_	_	_	_
53	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	_
57	genistein	genistein	PROPN	NNP	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	Gen	Gen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3219
# text = TNF-alpha release in culture supernatants was measured by an ELISA.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	release	release	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
7	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	ELISA	ELISa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3220
# text = NF-kappaB DNA binding was evaluated by electrophoretic mobility shift assay.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
11	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3221
# text = RESULTS: LPS increased NF-kappaB DNA binding and TNF-alpha release in human monocytes.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	release	release	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3222
# text = Nonspecific protein kinase inhibition inhibited NF-kappaB activation and TNF-alpha release, while specific PKC inhibition with Bis had no effect on LPS-induced NF-kappaB DNA binding or TNF-alpha release.
1	Nonspecific	Nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
19	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	Bis	Bis	PROPN	NNP	Number=Sing	_	_	_	_
22	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3223
# text = PTK inhibition with Gen attenuated both LPS-induced NF-kappaB DNA binding and TNF-alpha production in human monocytes.
1	PTK	Ptk	NOUN	NN	Number=Sing	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	Gen	Gen	PROPN	NNP	Number=Sing	_	_	_	_
5	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3224
# text = Direct activation of PKC with PMA induced both NF-kappaB activation and TNF-alpha production by human monocytes.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3225
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3226
# text = These results suggest that LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes are independent of PKC activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	release	release	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	PKC	PKC	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3227
# text = Furthermore, our results provide evidence that PTK plays a role in LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	thus	thus	ADV	RB	_	_	_	_	_
30	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
34	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	target	target	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	states	state	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3228
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3229
# text = Document 003001209 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001209	003001209	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3230
# text = Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	AZT	AZT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3231
# text = The small molecule S9a was derived from an established tumor necrosis factor-alpha (TNF-alpha) inhibitor (Canventol) by replacement of the isopropylidine group with a phenyl ring.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	S9	s9	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Canventol	Canventol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	isopropylidine	isopropylidine	NOUN	NN	Number=Sing	_	_	_	_
30	group	group	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	phenyl	phenyl	NOUN	NN	Number=Sing	_	_	_	_
34	ring	ring	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3232
# text = S9a at 10 to 100 nM inhibited HIV production as potently as 3'-azido-3'-deoxythymidine (AZT), an inhibitor of viral reverse transcriptase.
1	S9	S9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	100	100	NUM	CD	NumType=Card	_	_	_	_
7	nM	nm	PROPN	NNP	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	potently	potently	ADV	RB	_	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	azido	azido	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	deoxythymidine	deoxythymidine	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	AZT	AZT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
32	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3233
# text = Furthermore, S9a and AZT in combination, at noncytoxic concentrations strongly inhibited HIV-1 replication that was more than additive and substantially prolonged the appearance of virus both in acutely infected CD4+ lymphocytes (SupT) in culture and in peripheral blood mononuclear cells (PBMCs) infected with a primary HIV-1 isolate.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	S9	S9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	a	a	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	AZT	AZT	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	noncytoxic	noncytoxic	ADJ	JJ	Degree=Pos	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	additive	additive	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	substantially	substantially	ADV	RB	_	_	_	_	_
26	prolonged	prolonge	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	both	both	CCONJ	CC	_	_	_	_	_
32	in	in	ADV	RB	_	_	_	_	_
33	acutely	acutely	ADV	RB	_	_	_	_	_
34	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	SupT	SupT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
46	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
47	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
55	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
56	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	_
59	isolate	isolate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3234
# text = S9a inhibited TNF-alpha promoter-driven reporter gene activity.
1	S9	S9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3235
# text = It was proposed that the mechanism of antiviral action of S9a was on the host cell, by blocking TNF-alpha transcription via a Tat-induced tar-independent loop, which decreases downstream NF-kappaB activation of HIV-1 long terminal repeat (LTR).
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	S9	s9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	host	host	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	tar	tar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
33	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
47	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
48	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3236
# text = S9a was superior to the first generation compound Canventol, which was superior to the natural compound sarcophytol A, demonstrating that further structure-based enhancement of potency of these compounds is feasible.
1	S9	S9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	superior	superior	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
9	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
10	Canventol	Canventol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	superior	superior	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
18	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
19	sarcophytol	sarcophytol	NOUN	NN	Number=Sing	_	_	_	_
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	demonstrating	demonstrate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
25	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	feasible	feasible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3237
# text = This study suggests a therapeutic approach against AIDS by application of two drugs, one against a cellular and the other a viral target, which may provide an approach to the problem of frequent emergence of resistant variants to combinations of drugs that target only HIV genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
6	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
7	against	against	ADP	IN	_	_	_	_	_
8	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	application	application	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
36	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
39	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	target	target	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	only	only	ADV	RB	_	_	_	_	_
47	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
48	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3238
# text = Document 003001210 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001210	003001210	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3239
# text = Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity.
1	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	remote	remote	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	position	position	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3240
# text = Previous cotransfection experiments had demonstrated that ectopic expression of the lymphocyte-specific transcription factor Oct2 could efficiently activate a promoter containing an octamer motif.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	Oct2	oct2	NOUN	NN	Number=Sing	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	efficiently	efficiently	ADV	RB	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
25	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3241
# text = Oct2 expression was unable to stimulate a multimerized octamer enhancer element in HeLa cells, however.
1	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3242
# text = We have tested a variety of Oct2 isoforms generated by alternative splicing for the capability to activate an octamer enhancer in nonlymphoid cells and a B-cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
8	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
9	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
12	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	capability	capability	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
20	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3243
# text = Our analyses show that several Oct2 isoforms can stimulate from a remote position but that this stimulation is restricted to B cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
7	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	remote	remote	ADJ	JJ	Degree=Pos	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3244
# text = This result indicates the involvement of either a B-cell-specific cofactor or a specific modification of a cofactor or the Oct2 protein in Oct2-mediated enhancer activation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	either	either	CCONJ	CC	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3245
# text = Mutational analyses indicate that the carboxy-terminal domain of Oct2 is critical for enhancer activation.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3246
# text = Moreover, this domain conferred enhancing activity when fused to the Oct1 protein, which by itself was unable to stimulate from a remote position.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	fused	fuse	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Oct1	Oct1	PROPN	NNP	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	remote	remote	ADJ	JJ	Degree=Pos	_	_	_	_
25	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3247
# text = The glutamine-rich activation domain present in the amino-terminal portion of Oct2 and the POU domain contribute only marginally to the transactivation function from a distal position.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glutamine	glutamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	POU	POU	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	marginally	marginally	ADV	RB	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
30	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3248
# text = Document 003001211 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001211	003001211	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3249
# text = Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3250
# text = We have cloned a group of cDNAs representing mRNAs that are rapidly induced following adherence of human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	group	group	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
8	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
9	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	rapidly	rapidly	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3251
# text = One of the induced transcripts (MAD-3) encodes a protein of 317 amino acids with one domain containing five tandem repeats of the cdc10/ankyrin motif, which is 60% similar (46% identical) to the ankyrin repeat region of the precursor of NF-kappa B/KBF1 p50.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	317	317	NUM	CD	NumType=Card	_	_	_	_
16	amino	amino	DET	DT	_	_	_	_	_
17	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	one	one	NUM	CD	NumType=Card	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	five	five	NUM	CD	NumType=Card	_	_	_	_
23	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
24	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cdc10	cdc10	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
30	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	%	%	SYM	NN	Number=Sing	_	_	_	_
36	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	46	46	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	%	%	SYM	NN	Number=Sing	_	_	_	_
40	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
45	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	region	region	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
54	B/KBF1	B/kbf1	PROPN	NNP	Number=Sing	_	_	_	_
55	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3252
# text = The C-terminus has a putative protein kinase C phosphorylation site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	c	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3253
# text = In vitro translated MAD-3 protein was found to specifically inhibit the DNA-binding activity of the p50/p65 NF-kappa B complex but not that of the p50/p50 KBF1 factor or of other DNA-binding proteins.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	specifically	specifically	ADV	RB	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	p50	p50	NUM	CD	NumType=Card	_	_	_	_
36	KBF1	KBF1	NUM	CD	NumType=Card	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3254
# text = The MAD-3 cDNA encodes an I kappa B-like protein that is likely to be involved in regulation of transcriptional responses to NF-kappa B, including adhesion-dependent pathways of monocyte activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3255
# text = Document 003001212 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001212	003001212	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3256
# text = Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	anetholdithiolthione	anetholdithiolthione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3257
# text = Nuclear factor (NF)-kappa B is a redox sensitive cytosolic transcription factor.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3258
# text = Redox regulation of NF-kappa B has been implicated in the activation of the human immuno-deficiency virus (HIV).
1	Redox	Redox	NOUN	NN	Number=Sing	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immuno	immuno	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-deficiency	-deficiency	NOUN	NN	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3259
# text = Therefore, inhibition of NF-kappa B activation may be an effective strategy for acquired immunodeficiency syndrome therapy.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
14	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	acquired	acquire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
19	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3260
# text = Anetholdithiolthione (ADT, 5-[p-methoxyphenyl]-3H-1,2-dithiol-3-thione) is an antioxidant which has been used to protect against acetaminophen- and CCl4-induced hepatotoxicity, lipid peroxidation, radiation injury, and also has been used clinically as an anti-choleretic agent.
1	Anetholdithiolthione	Anetholdithiolthione	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	5-[	5-[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	p-methoxyphenyl]-3H-1,2-dithiol	p-methoxyphenyl]-3H-1,2-dithiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	thione	thione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
20	against	against	ADP	IN	_	_	_	_	_
21	acetaminophen	acetaminophe	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	CCl4	Ccl4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	hepatotoxicity	hepatotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
30	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	_
33	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	also	also	ADV	RB	_	_	_	_	_
37	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	clinically	clinically	ADV	RB	_	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	anti-choleretic	anti-choleretic	ADJ	JJ	Degree=Pos	_	_	_	_
44	agent	agent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3261
# text = The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ADT	Adt	ADJ	JJ	Degree=Pos	_	_	_	_
9	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
29	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
30	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
36	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3262
# text = PMA and TNF alpha induced activation of (NF)-kappa B in human Jurkat T-cells was partially inhibited by ADT (0.1 mM) pretreatment.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	T-	t-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	partially	partially	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_
26	mM	mm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3263
# text = ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells.
1	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_
4	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
18	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	Wurzburg	Wurzburg	NOUN	NN	Number=Sing	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3264
# text = Furthermore, ADT treated Wurzburg cells had significantly higher glutathione levels as compared with untreated cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	_
4	treated	treat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
10	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3265
# text = H2O2 induced lipid peroxidation in Wurzburg cells was remarkably inhibited by ADT pretreatment.
1	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
4	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	remarkably	remarkably	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	ADT	Adt	ADJ	JJ	Degree=Pos	_	_	_	_
13	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3266
# text = ADT, a pro-glutathione antioxidant, was observed to be capable of modulating NF-kappa B activation.
1	ADT	ADT	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	pro-glutathione	pro-glutathione	ADJ	JJ	Degree=Pos	_	_	_	_
5	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	SCONJ	IN	_	_	_	_	_
13	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3267
# text = Document 003001213 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001213	003001213	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3268
# text = A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-like	-like	ADP	IN	_	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	preferentially	preferentially	ADV	RB	_	_	_	_	_
14	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
22	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
23	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
24	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3269
# text = The proto-oncoprotein c-Rel is a member of the nuclear factor kappa B transcription factor family, which includes the p50 and p65 subunits of nuclear factor kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proto-oncoprotein	proto-oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
3	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	member	member	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	p65	p65	NUM	CD	NumType=Card	_	_	_	_
25	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3270
# text = We show here that c-Rel binds to kappa B sites as homodimers as well as heterodimers with p50.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
8	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3271
# text = These homodimers and heterodimers show distinct DNA-binding specificities and affinities for various kappa B motifs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3272
# text = In particular, the c-Rel homodimer has a high affinity for interleukin-6 (IL-6) and beta interferon kappa B sites.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
8	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3273
# text = In spite of its association with p50 in vitro, however, we found a lymphoid cell-specific nuclear factor in vivo that contains c-Rel but not p50 epitopes; this factor, termed IL-6 kappa B binding factor
1	In	in	ADP	IN	_	_	_	_	_
2	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	association	association	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	p50	p50	NUM	CD	NumType=Card	_	_	_	_
32	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	6	6	NUM	CD	NumType=Card	_	_	_	_
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	_
43	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3274
# text = II, appears to contain the c-Rel homodimer and preferentially recognizes several IL-6 kappa B-related kappa B motifs.
1	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	preferentially	preferentially	ADV	RB	_	_	_	_	_
13	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3275
# text = Although it has been previously shown that the IL-6 kappa B motif functions as a potent IL-1/tumor necrosis factor-responsive element in nonlymphoid cells, its activity was found to be repressed in lymphoid cells such as a Jurkat T-cell line.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-responsive	-responsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	element	element	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
43	as	as	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
46	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3276
# text = We also present evidence that IL-6 kappa B binding factor II functions as a repressor specific for IL-6 kappa B-related kappa B motifs in lymphoid cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3277
# text = Document 003001214 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001214	003001214	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3278
# text = The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
11	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3279
# text = PU.1 is a hematopoietic transcription factor belonging to the Ets-family.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Ets-	ets-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3280
# text = It is identical to the Spi-1 oncogene, which is implicated in spleen focus-forming virus-induced murine erythroleukemias.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	spleen	spleen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	focus	focus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
22	erythroleukemias	erythroleukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3281
# text = PU.1 seems to be required for early development of multiple hematopoietic lineages, but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage-differentiation lineage.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	preferentially	preferentially	ADV	RB	_	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	and	and	CCONJ	CC	_	_	_	_	_
31	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	macrophage-differentiation	macrophage-differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3282
# text = It binds the so-called Pu box, an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Pu	Pu	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	number	number	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3283
# text = We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to differentiated plasma cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
32	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	differentiated	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
35	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3284
# text = PU.1 mRNA expression and PU.1 DNA binding activity, as measured by Northern blot analysis and electrophoretic mobility shift assay, respectively, were evident in cell lines representing pro-B, pre-B, and mature B cells.
1	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	PU.1	PU.1	NOUN	NN	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
14	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
15	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
20	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
30	pro	pro	ADP	IN	Typo=Yes	_	_	_	SpaceAfter=No
31	-B	-b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
34	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3285
# text = We could also show Pu box-dependent transactivation of a reporter gene in transient transfections in these cell lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	Pu	Pu	PROPN	NNP	Number=Sing	_	_	_	_
6	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3286
# text = In contrast, in a number of multiple myeloma cell lines, representing differentiated, plasma cell-like B cells, PU.1 DNA binding activity, mRNA expression, and Pu box-dependent transactivation were absent or detectable at a very low level.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	number	number	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
14	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Pu	Pu	PROPN	NNP	Number=Sing	_	_	_	_
33	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	very	very	ADV	RB	_	_	_	_	_
44	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
45	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3287
# text = In lymphoblastoid cell lines, which exemplify an intermediate stage of B-cell differentiation, a reduced expression and activity were observed.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	exemplify	exemplify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
10	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3288
# text = The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	examples	example	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	apparently	apparently	ADV	RB	_	_	_	_	_
23	contradict	contradict	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3289
# text = At present, it is unclear whether the lack of PU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells.
1	At	at	ADP	IN	_	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	exemplifies	exemplify	NOUN	NNS	Number=Plur	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
34	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	terminally	terminally	ADV	RB	_	_	_	_	_
38	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3290
# text = Document 003001215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001215	003001215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3291
# text = Expression of v-src in T cells correlates with nuclear expression of NF-kappa B. NF-kappa B is a rapidly inducible transcriptional activator that responds to a variety of signals and influences the expression of many genes involved in the immune response.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	src	src	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	rapidly	rapidly	ADV	RB	_	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
41	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
42	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3292
# text = Protein tyrosine kinases transmit signals from cytokine and immune receptors.
1	Protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
2	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	transmit	transmit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3293
# text = Very little information exists linking these two important classes of signaling molecules.
1	Very	very	ADV	RB	_	_	_	_	_
2	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
3	information	information	NOUN	NN	Number=Sing	_	_	_	_
4	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3294
# text = We now demonstrate that v-src expression correlates with nuclear expression of a kappa B binding complex similar to that induced by phorbol ester and ionomycin, as detected by electrophoretic mobility shift assay using a variety of kappa B sites.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	src	src	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
17	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
24	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
34	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
35	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3295
# text = This complex was blocked by the tyrosine kinase inhibitor, herbimycin A.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3296
# text = The v-src-induced complex comprised the p50 and p65 components of NF-kappa B, as determined by supershift and immunoblot analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	src-induced	src-induce	ADJ	JJ	Degree=Pos	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
5	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
10	components	component	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
23	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3297
# text = As a functional correlate of this finding, transient co-transfection of HIV-1 LTR reporter constructs in a different T cell line demonstrated that v-src activated this promoter in a kappa B-dependent manner.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	finding	finding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	ADJ	JJR	Degree=Cmp	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	constructs	construct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	src	src	NOUN	NN	Number=Sing	_	_	_	_
28	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3298
# text = We found that transactivation of the HIV-1 LTR by v-src was more sensitive to mutations of the proximal, rather than the distal, kappa B element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	src	src	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	rather	rather	ADV	RB	_	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	kappa	kappa	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3299
# text = The implications for T cell receptor signaling and HIV-1 gene expression are considered.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3300
# text = Document 003001216 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001216	003001216	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3301
# text = Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3302
# text = The kappa B sequence (GGGACTTTCC) binds a factor, NF-kappa B, that is constitutively found in its functional, DNA binding form only in B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	GGGACTTTCC	GGGACTTTCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	form	from	NOUN	NN	Number=Sing	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3303
# text = A factor with apparently indistinguishable sequence specificity can be induced in many other cell types, where it is used to regulate inducible gene expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	apparently	apparently	ADV	RB	_	_	_	_	_
5	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3304
# text = For example, kappa B-related sequences have been shown to be important for the transcription of a few inducible genes, such as the interleukin 2 receptor alpha-chain gene and the beta-interferon gene.
1	For	for	ADP	IN	_	_	_	_	_
2	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3305
# text = However, these genes are not constitutively active in B lymphocytes, suggesting that other regulatory mechanisms must play a role in determining the patterns of expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
19	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3306
# text = We have investigated the constitutive and inducible transcriptional activity mediated by five kappa B-related sequence elements in two different cell types.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3307
# text = We show that in S194 plasma cells the activity of each element correlates well with the relative affinity of B-cell-derived NF-kappa B for that element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	S194	S194	NUM	CD	NumType=Card	_	_	_	_
6	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	each	each	DET	DT	_	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
18	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3308
# text = This leads to significantly lower transcription enhancement by sites derived from the interleukin 2 receptor or T-cell receptor genes in S194 cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	lower	lower	VERB	VB	VerbForm=Inf	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	S194	S194	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3309
# text = However, in either EL-4 (T) cells or S194 cells, both lower-affinity sites can be significantly induced by the tax gene product of human T-cell leukemia virus type I, showing that NF-kappa B activity can be modulated even in a B-cell line that constitutively expresses this factor.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	either	either	DET	DT	_	_	_	_	_
5	EL	EL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	T	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	S194	S194	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	significantly	significantly	ADV	RB	_	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	product	product	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
35	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
36	type	type	NOUN	NN	Number=Sing	_	_	_	_
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
46	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
47	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
48	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	even	even	ADV	RB	_	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
55	line	line	NOUN	NN	Number=Sing	_	_	_	_
56	that	that	PRON	WDT	PronType=Rel	_	_	_	_
57	constitutively	constitutively	ADV	RB	_	_	_	_	_
58	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
59	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
60	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3310
# text = Document 003001217 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001217	003001217	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3311
# text = Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	interferon	interferon	ADP	IN	_	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3312
# text = Three aspects of the involvement of tumor necrosis factor in human immunodeficiency virus (HIV) pathogenesis were examined.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3313
# text = Tumor necrosis factor alpha (TNF-alpha) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line (U9-IIIB).
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
18	amplification	amplification	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	U937	U937	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	chronically	chronically	ADV	RB	_	_	_	_	_
27	HIV	haHive	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	U937	U937	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	U9-	u9-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3314
# text = TNF-alpha RNA was undetectable in U937 cells, whereas a low constitutive level was detected in U9-IIIB cells.
1	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U9-	U9-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	IIIB	Iiib	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3315
# text = Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells, suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection.
1	Paramyxovirus	Paramyxovirus	NOUN	NN	Number=Sing	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	state	state	NOUN	NN	Number=Sing	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	U9	U9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	IIIB	IIIB	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
46	than	than	ADP	IN	_	_	_	_	_
47	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	after	after	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
53	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
54	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3316
# text = The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat (LTR) and the beta interferon promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
19	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
20	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
21	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
28	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
29	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
30	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
37	interferon	interferon	ADP	IN	_	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3317
# text = In U937 and Jurkat T lymphoid cells, the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B-containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	U937	U937	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
22	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
23	varied	vary	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
48	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
49	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	directly	directly	ADV	RB	_	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
57	B	b	PROPN	NNP	Number=Sing	_	_	_	_
58	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3318
# text = Although the intact beta interferon promoter was only weakly stimulated by phorbol ester or TNF-alpha, multimers of the PRDII NF-kappa B-binding domain were inducible by both agents.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	weakly	weakly	ADV	RB	_	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	multimers	multimer	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	PRDII	PRDII	PROPN	NNP	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3319
# text = TNF-alpha was able to increase expression of the HIV LTR in T cells, but in monocytic cells, TNF-alpha did not induce the HIV LTR above a constitutive level of activity.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
30	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
31	above	above	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3320
# text = This level of NF-kappa B-independent activity appears to be sufficient for virus multiplication, since TNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 (HIV-1) infection and viral RNA production in U937 cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	multiplication	multiplication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	since	since	SCONJ	IN	_	_	_	_	_
20	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	no	no	DET	DT	_	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	de	de	PROPN	NNP	Number=Sing	_	_	_	_
32	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
44	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
45	production	production	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	U937	U937	NUM	CD	NumType=Card	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3321
# text = However, in Jurkat cells, TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis, indicating that in T cells HIV-1 multiplication was stimulated by TNF-alpha treatment.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	dramatically	dramatically	ADV	RB	_	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	spread	spread	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
25	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	multiplication	multiplication	NOUN	NN	Number=Sing	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	alpha	alpha	ADP	IN	_	_	_	_	_
43	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3322
# text = Document 003001218 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001218	003001218	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3323
# text = Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene.
1	Polymorphic	Polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
2	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
3	within	within	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	mediate	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3324
# text = Atopy, which predisposes individuals to develop asthma, severe systemic anaphylaxis, and atopic dermatitis, is usually associated with dramatically elevated total serum IgE levels and is thought to be controlled by a major susceptibility gene and multiple minor susceptibility genes.
1	Atopy	Atopy	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	predisposes	predispose	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
8	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
11	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
12	anaphylaxis	anaphylaxis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
16	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	usually	usually	ADV	RB	_	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	dramatically	dramatically	ADV	RB	_	_	_	_	_
23	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
25	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
26	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
37	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
41	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
42	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
43	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3325
# text = A recent sib-pair analysis revealed a tight linkage between markers on 5q31.1 and a major susceptibility gene controlling total serum IgE levels.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	sib-pair	sib-pair	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
8	linkage	linkage	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	5q31.1	5q31.1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
16	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
21	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3326
# text = Due to its location within this cluster and its biologic role in Ig class switching and Th2 cell differentiation, the IL-4 gene has emerged as one major candidate for the atopy gene.
1	Due	due	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	location	location	NOUN	NN	Number=Sing	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	switching	switching	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	emerged	emerge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	one	one	NUM	CD	NumType=Card	_	_	_	_
30	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
31	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	atopy	atopy	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3327
# text = In one model, polymorphisms within IL-4 regulatory elements might result in overexpression of the gene, amplifying Th2 cell differentiation and class switching to IgE.
1	In	in	ADP	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	amplifying	amplify	VERB	VBG	VerbForm=Ger	_	_	_	_
21	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3328
# text = In support of this model, we report that the human IL-4 promoter exists in multiple allelic forms that exhibit distinct transcriptional activities in IL-4-positive T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	support	support	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
20	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	exhibit	exhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3329
# text = A particular allele has an unusually high transcriptional activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
3	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	unusually	unusually	ADV	RB	_	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3330
# text = A nucleotide substitution within a recently described OAP40 element located just upstream of an NF-AT site (P sequence) appears to be largely responsible for the increased promotor strength of this particular allelic form of the IL-4 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
3	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	recently	recently	ADV	RB	_	_	_	_	_
7	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	OAP40	OAP40	NUM	CD	NumType=Card	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	just	just	ADV	RB	_	_	_	_	_
12	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	P	p	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	largely	largely	ADV	RB	_	_	_	_	_
27	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promotor	promotor	NOUN	NN	Number=Sing	_	_	_	_
32	strength	strength	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
36	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
37	form	form	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3331
# text = In EMSAs, this substitution results in a markedly enhanced affinity for sequence-specific complexes exhibiting an AP-1 specificity.
1	In	in	ADP	IN	_	_	_	_	_
2	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	exhibiting	exhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3332
# text = The identification of allelic nucleotides, which results in overexpression of the IL-4 gene, provides specific targets for a comprehensive screening of atopic and nonatopic individuals and may provide a clue for genetic predisposition for atopy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
5	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	DET	WDT	PronType=Int	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	comprehensive	comprehensive	ADJ	JJ	Degree=Pos	_	_	_	_
24	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
29	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	clue	clue	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
37	predisposition	predisposition	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	atopy	atopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3333
# text = Document 003001219 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001219	003001219	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3334
# text = Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3335
# text = Nuclear factor of activated T cells (NFAT) is a transcriptional activator that binds to sequences in the interleukin-2 (IL-2) promoter and is thought to be largely responsible for the T cell-specific inducibility of IL-2 expression.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	largely	largely	ADV	RB	_	_	_	_	_
35	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	T	T	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3336
# text = Electrophoretic mobility shift assays (EMSA) showed that specific NFAT binding activity could also be induced in human B cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3337
# text = The B cell NFAT complex, however, was not functional, since it failed to activate transcription from an NFAT-driven chloramphenicol acetyltransferase (CAT) construct.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
25	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3338
# text = Competition with an AP-1 motif or with anti-Jun and anti-Fos antibodies abolished binding to the NFAT motif in both T and B cells, indicating that Jun and Fos are critical for NFAT complex formation in both cell types.
1	Competition	competition	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anti-Jun	anti-Jun	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	anti-Fos	anti-Fos	ADJ	JJ	Degree=Pos	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
19	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
36	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
37	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	both	both	DET	DT	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3339
# text = Purified recombinant Jun and Fos proteins failed to bind directly to the NFAT motif.
1	Purified	Purify	ADJ	JJ	Degree=Pos	_	_	_	_
2	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
3	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	directly	directly	ADV	RB	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3340
# text = However, when combined with unstimulated B or T cell extracts, full-length, but not truncated, Jun/Fos heterodimers were able to form an NFAT complex, indicating the presence of a constitutively expressed nuclear factor(s) in B and T cells necessary for the formation of the NFAT complex in both cell types.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	length	length	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Jun/	Jun/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
23	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
30	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	constitutively	constitutively	ADV	RB	_	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	s	s	X	AFX	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	B	b	PROPN	NNP	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
50	for	for	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
56	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	both	both	DET	DT	_	_	_	_	_
59	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
60	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3341
# text = An NFAT oligonucleotide carrying mutations in the 5' purine-rich part of the NFAT sequence failed to form a complex and to compete with the wild type motif for NFAT complex formation in both T and B cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
3	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
4	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	's	PUNCT	``	_	_	_	_	_
10	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
13	part	part	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	wild	wild	NOUN	NN	Number=Sing	_	_	_	_
29	type	type	NOUN	NN	Number=Sing	_	_	_	_
30	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
33	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
34	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	both	both	CCONJ	CC	_	_	_	_	_
37	T	T	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3342
# text = We therefore propose a model whereby a core NFAT complex consisting of Jun, Fos, and a constitutive nuclear factor is formed in both T and B cells, but an additional factor and/or post-translational modification of a factor, missing in B cells, might be required for transactivation by NFAT.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	whereby	whereby	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	or	or	CCONJ	CC	_	_	_	_	_
38	post-translational	post-translational	ADJ	JJ	Degree=Pos	_	_	_	_
39	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	missing	missing	VERB	VBG	VerbForm=Ger	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
50	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
51	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	for	for	ADP	IN	_	_	_	_	_
53	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3343
# text = Document 003001220 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001220	003001220	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3344
# text = Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.
1	Distinctive	Distinctive	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
8	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
12	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3345
# text = cDNA microarrays and a clustering algorithm were used to identify patterns of gene expression in human mammary epithelial cells growing in culture and in primary human breast tumors.
1	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
2	microarrays	microarray	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	clustering	clustering	NOUN	NN	Number=Sing	_	_	_	_
6	algorithm	algorithm	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
11	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
18	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
28	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3346
# text = Clusters of coexpressed genes identified through manipulations of mammary epithelial cells in vitro also showed consistent patterns of variation in expression among breast tumor samples.
1	Clusters	Cluster	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	manipulations	manipulation	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
10	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
17	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	among	among	ADP	IN	_	_	_	_	_
23	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3347
# text = By using immunohistochemistry with antibodies against proteins encoded by a particular gene in a cluster, the identity of the cell type within the tumor specimen that contributed the observed gene expression pattern could be determined.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	specimen	speciman	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	contributed	contribute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
34	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3348
# text = Clusters of genes with coherent expression patterns in cultured cells and in the breast tumors samples could be related to specific features of biological variation among the samples.
1	Clusters	Cluster	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	coherent	coherent	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
15	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
16	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
25	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
26	among	among	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3349
# text = Two such clusters were found to have patterns that correlated with variation in cell proliferation rates and with activation of the IFN-regulated signal transduction pathway, respectively.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
8	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3350
# text = Clusters of genes expressed by stromal cells and lymphocytes in the breast tumors also were identified in this analysis.
1	Clusters	Cluster	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
13	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3351
# text = These results support the feasibility and usefulness of this systematic approach to studying variation in gene expression patterns in human cancers as a means to dissect and classify solid tumors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	feasibility	feasibility	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	usefulness	usefulness	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	systematic	systematic	ADJ	JJ	Degree=Pos	_	_	_	_
11	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	SCONJ	IN	_	_	_	_	_
13	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
14	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	means	means	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	dissect	dissect	VERB	VB	VerbForm=Inf	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	classify	classify	VERB	VB	VerbForm=Inf	_	_	_	_
29	solid	solid	ADJ	JJ	Degree=Pos	_	_	_	_
30	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3352
# text = Document 003001221 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001221	003001221	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3353
# text = Association between expression of intercellular adhesion molecule-1 and integration of human T-cell-leukemia virus type 1 in adult T-cell leukemia cells.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-leukemia	-leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
22	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3354
# text = It is known that the expression levels of intercellular adhesion molecule-1 (ICAM-1) in adult T cell leukemia(ATL) cells are high, whereas those in T-lymphoid cells are not.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
23	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3355
# text = In order to investigate the factors that influence the induction of ICAM-1 molecules, Northern blot analysis to measure the expression level of ICAM-1 mRNAs and Southern blot hybridization to analyze the integration of human T-cell-leukemia virus type 1 (HTLV-1) provirus were done.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	influence	influence	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
18	blot	blot	ADJ	JJ	Degree=Pos	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	measure	measure	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Southern	Southern	ADJ	JJ	Degree=Pos	_	_	_	_
32	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
33	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	T-cell	T-cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
43	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
44	type	type	NOUN	NN	Number=Sing	_	_	_	_
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	done	do	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3356
# text = The levels of ICAM-1 mRNA expression of ATL cells were generally higher than those of T-lymphoid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	generally	generally	ADV	RB	_	_	_	_	_
14	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
15	than	than	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3357
# text = However, ILT-mat cells and ATL16T(-) cells, although they were ATL cells, showed rather low surface ICAM-1 expression and ICAM-1 mRNA expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ILT	ILT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mat	mat	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	ATL16T	Atl16t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	-)	-)	PUNCT	.	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	although	although	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	rather	rather	ADV	RB	_	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3358
# text = Southern blot hybridization showed that only two and four bands were found in ILT-mat and ATL16T(-) cells, respectively, whereas > 10 bands were detected in other ATL cells.
1	Southern	southern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	four	four	NUM	CD	NumType=Card	_	_	_	_
10	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	ILT	ILT	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mat	mat	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	ATL16T	Atl16t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	-)	-)	PUNCT	.	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	NOUN	NNS	Number=Plur	_	_	_	_
26	>	>	PUNCT	,	_	_	_	_	_
27	10	10	NUM	CD	NumType=Card	_	_	_	_
28	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3359
# text = These results suggest that monoclonal integration of HTLV-1 provirus to the genome of T cell, especially the number of integration sites, is one of the factors for induction of ICAM-1 molecules.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	especially	especially	ADV	RB	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	number	number	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	one	one	NUM	CD	NumType=Card	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3360
# text = Document 003001222 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001222	003001222	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3361
# text = Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	anti-HLA	anti-hla	ADJ	JJ	Degree=Pos	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
22	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3362
# text = Monoclonal antibodies against either monomorphic or polymorphic determinants of class I antigen induced in PBMC and highly purified T lymphocytes the nuclear activity of NF-kappa B/Rel complexes.
1	Monoclonal	Monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
2	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
3	against	against	ADP	IN	_	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	monomorphic	monomorphic	ADJ	JJ	Degree=Pos	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
8	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	highly	highly	ADV	RB	_	_	_	_	_
18	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
31	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3363
# text = These included both p50/p50 and p50/p65 dimers, recognized by specific antibodies in EMSA.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	p50/p50	p50/p50	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
9	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3364
# text = The induced complexes were detectable in extracts of cells incubated with anti-class I monoclonal antibody (mAb) for 1.5 h; the induction was maximal at 5 h, persistent at 16 h and no longer observed at 40 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induced	induced	ADJ	JJ	Degree=Pos	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	anti-class	anti-class	NOUN	NN	Number=Sing	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
15	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	1.5	1.5	NUM	CD	NumType=Card	_	_	_	_
21	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	5	5	NUM	CD	NumType=Card	_	_	_	_
29	h	h	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	16	16	NUM	CD	NumType=Card	_	_	_	_
34	h	h	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	no	no	ADV	RB	_	_	_	_	_
37	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
38	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	at	at	ADP	IN	_	_	_	_	_
40	40	40	NUM	CD	NumType=Card	_	_	_	_
41	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3365
# text = The mAb failed to induce NF-kappa B/Rel nuclear activity in cells incubated in the presence of 3,4-dichloroisocoumarin, an inhibitor of I kappa B-alpha degradation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
3	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	3,4	3,4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-dichloroisocoumarin	-dichloroisocoumarin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3366
# text = Together, these results suggest that class I triggering can induce the activity of NF-kappa
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3367
# text = B/Rel nuclear activity in peripheral blood T lymphocytes, thereby modulating the expression of genes regulated by these transcription factors.
1	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	T	t	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	thereby	thereby	ADV	RB	_	_	_	_	_
13	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3368
# text = Document 003001223 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001223	003001223	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3369
# text = Regulation of gene expression at early stages of B-cell and T-cell differentiation.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3370
# text = The expression of distinct sets of genes at different stages of B-lymphocyte and T-lymphocyte differentiation is controlled at the level of transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3371
# text = A number of recent studies have described interactions between transcription factors in lymphocytes that provide new insights into mechanisms regulating gene expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
17	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3372
# text = These mechanisms include the assembly of higher order nucleoprotein complexes and other protein-protein interactions that enhance the functional specificity of transcriptional regulators in lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
8	order	order	NOUN	NN	Number=Sing	_	_	_	_
9	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3373
# text = Document 003001224 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001224	003001224	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3374
# text = Oleic acid inhibits endothelial activation :
1	Oleic	Oleic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3375
# text = A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
4	antiatherogenic	antiatherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	nutritional	nutritional	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mediterranean	mediterranean	ADJ	JJ	Degree=Pos	_	_	_	_
13	diet	diet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3376
# text = Because oleic acid is implicated in the antiatherogenic effects attributed to the Mediterranean diet, we investigated whether this fatty acid can modulate endothelial activation, ie, the concerted expression of gene products involved in leukocyte recruitment and early atherogenesis.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	oleic	oleic	ADJ	JJ	Degree=Pos	_	_	_	_
3	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	antiatherogenic	antiatherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Mediterranean	Mediterranean	PROPN	NNP	Number=Sing	_	_	_	_
14	diet	diet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	whether	whether	SCONJ	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
21	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	concerted	concerted	ADJ	JJ	Degree=Pos	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	products	product	NOUN	NNS	Number=Plur	_	_	_	_
35	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
38	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
41	atherogenesis	atherogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3377
# text = We incubated sodium oleate with human umbilical vein endothelial cells for 0 to 72 hours, followed by coincubation of oleate with human recombinant tumor necrosis factor, interleukin (IL)-1alpha, IL-1beta, IL-4, Escherichia coli lipopolysaccharide (LPS), or phorbol 12-myristate 13-acetate for a further 6 to 24 hours.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	incubated	incubate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
4	oleate	oleate	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
8	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	0	0	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	72	72	NUM	CD	NumType=Card	_	_	_	_
15	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	coincubation	coincubation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
46	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
47	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	or	or	CCONJ	CC	_	_	_	_	_
53	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
54	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
57	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
60	for	for	ADP	IN	_	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
63	6	6	NUM	CD	NumType=Card	_	_	_	_
64	to	to	ADP	IN	_	_	_	_	_
65	24	24	NUM	CD	NumType=Card	_	_	_	_
66	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3378
# text = The endothelial expression of vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and intercellular adhesion molecule-1 was monitored by cell surface enzyme immunoassays or flow cytometry, and steady-state levels of VCAM-1 mRNA were assessed by Northern blot analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	E-	E-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
32	immunoassays	immunoassay	NOUN	NNS	Number=Plur	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
35	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	state	state	NOUN	NN	Number=Sing	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
51	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
52	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3379
# text = At 10 to 100 micromol/L for >24 hours, oleate inhibited the expression of all adhesion molecules tested.
1	At	at	ADP	IN	_	_	_	_	_
2	10	10	NUM	CD	NumType=Card	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	100	100	NUM	CD	NumType=Card	_	_	_	_
5	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
8	24	24	NUM	CD	NumType=Card	_	_	_	_
9	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	oleate	oleate	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3380
# text = After a 72-hour incubation with oleate and a further 16-hour incubation with oleate plus 1 microg/mL LPS, VCAM-1 expression was reduced by >40% compared with control.
1	After	after	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
6	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
12	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
15	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
18	plus	plus	CCONJ	CC	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	mL	mL	PROPN	NNP	Number=Sing	_	_	_	_
23	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	>	>	SYM	$	_	_	_	_	SpaceAfter=No
33	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	%	%	SYM	NN	Number=Sing	_	_	_	_
35	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3381
# text = Adhesion of monocytoid U937 cells to LPS-treated endothelial cells was reduced concomitantly.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	concomitantly	concomitantly	ADV	RB	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3382
# text = Oleate also produced a quantitatively similar reduction of VCAM-1 mRNA levels on Northern blot analysis and inhibited nuclear factor-kappaB activation on electrophoretic mobility shift assays.
1	Oleate	Oleate	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	quantitatively	quantitatively	ADV	RB	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
16	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
27	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
28	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
29	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3383
# text = Incubation of endothelial cells with oleate for 72 hours decreased the relative proportions of saturated (palmitic and stearic) acids in total cell lipids and increased the proportions of oleate in total cell lipids without significantly changing the relative proportions of polyunsaturated fatty acids.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	72	72	NUM	CD	NumType=Card	_	_	_	_
9	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
13	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	saturated	saturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	palmitic	palmitic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	stearic	stearic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lipids	lipid	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lipids	lipid	NOUN	NNS	Number=Plur	_	_	_	_
36	without	without	SCONJ	IN	_	_	_	_	_
37	significantly	significantly	ADV	RB	_	_	_	_	_
38	changing	change	VERB	VBG	VerbForm=Ger	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
41	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	polyunsaturated	polyunsaturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
45	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3384
# text = Although less potent than polyunsaturated fatty acids in inhibiting endothelial activation, oleic acid may contribute to the prevention of atherogenesis through selective displacement of saturated fatty acids in cell membrane phospholipids and a consequent modulation of gene expression for molecules involved in monocyte recruitment.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	less	less	ADJ	JJS	Degree=Sup	_	_	_	_
3	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
4	than	than	ADP	IN	_	_	_	_	_
5	polyunsaturated	polyunsaturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
7	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	oleic	oleic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	displacement	displacement	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	saturated	saturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
28	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
32	phospholipids	phospholipid	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
36	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
42	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
45	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3385
# text = Document 003001225 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001225	003001225	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3386
# text = Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	3q21	3q21	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	intergenic	intergenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
13	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	ecotropic	ecotropic	ADJ	JJ	Degree=Pos	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3387
# text = We have identified a novel gene, GR6, located within the leukemia breakpoint region of 3q21, that is normally expressed in early fetal development but not in adult peripheral blood.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	GR6	Gr6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	breakpoint	breakpoint	NOUN	NN	Number=Sing	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	3q21	3q21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	normally	normally	ADV	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
25	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
31	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
32	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3388
# text = GR6 is activated in the UCSD-AML1 cell line and in a leukemic sample, both of which carry a t(3;3)(q21;q26).
1	GR6	Gr6	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	UCSD	Ucsd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	AML1	Aml1	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	sample	sample	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	carry	carry	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	3;3	3;3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	q21;q26	q21;q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3389
# text = In UCSD-AML1, we have also identified fusion transcripts between the ecotropic viral insertion site I (EVI1) gene in 3q26 and GR6 and between EVI1 and Ribophorin I that maps 30 kb telomeric to GR6 in 3q21.
1	In	in	ADP	IN	_	_	_	_	_
2	UCSD	UCSD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ecotropic	ecotropic	ADJ	JJ	Degree=Pos	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	EVI1	EVI1	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	3q26	3q26	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	GR6	GR6	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Ribophorin	Ribophorin	PROPN	NNP	Number=Sing	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	maps	map	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	30	30	NUM	CD	NumType=Card	_	_	_	_
36	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
37	telomeric	telomeric	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	GR6	GR6	NUM	CD	NumType=Card	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	3q21	3q21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3390
# text = All fusions splice the 5' ends of the 3q21 genes into exon 2 of the EVI1 gene, an event that is similar to the normal intergenic splicing of MDS1-EVI1 and to those previously documented in leukemias with t(3;21) and t(3;12), in which acute myelogenous leukemia 1-EVI1 fusions and ETV6-EVI1 fusions, respectively, occur.
1	All	all	DET	DT	_	_	_	_	_
2	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
3	splice	splice	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	's	PUNCT	``	_	_	_	_	_
7	ends	end	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	3q21	3q21	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	event	event	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	intergenic	intergenic	ADJ	JJ	Degree=Pos	_	_	_	_
29	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	MDS	Md	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	EVI1	EVI1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
38	previously	previously	ADV	RB	_	_	_	_	_
39	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	leukemias	leukemias	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	t(	t(	SYM	NFP	_	_	_	_	SpaceAfter=No
44	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	3;12	3;12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	which	which	PRON	WDT	PronType=Rel	_	_	_	_
54	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
55	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
56	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
57	1-	1-	SYM	SYM	_	_	_	_	SpaceAfter=No
58	EVI1	Evi1	NUM	CD	NumType=Card	_	_	_	_
59	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	ETV6	ETV6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	-EVI1	-evi1	NOUN	NN	Number=Sing	_	_	_	_
63	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	occur	occur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3391
# text = The Ribophorin I-EVI1 fusion in particular may be a common occurrence in t(3;3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ribophorin	Ribophorin	PROPN	NNP	Number=Sing	_	_	_	_
3	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3392
# text = Document 003001226 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001226	003001226	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3393
# text = Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	repeat	repeat	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	quasispecies	quasispecy	NOUN	NNS	Number=Plur	_	_	_	_
10	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3394
# text = The generation of genomic diversity during the course of infection has the potential to affect all aspects of HIV-1 replication, including expression of the proviral genome.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
5	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	course	course	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
29	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3395
# text = To gain a better understanding of the impact of long terminal repeat (LTR) sequence diversity on LTR-directed gene expression in cells of the central nervous system (CNS) and immune system, we amplified and cloned LTRs from proviral DNA in HIV-1-infected peripheral blood.
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	LTR-	LTR-	X	AFX	_	_	_	_	SpaceAfter=No
20	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
28	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CNS	Cn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
35	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
38	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
42	from	from	ADP	IN	_	_	_	_	_
43	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
52	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3396
# text = Sequence analysis of nineteen LTRs cloned from 2 adult and 3 pediatric patients revealed an average of 33 nucleotide changes (with respect to the sequence of the LAI LTR) within the 455-bp U3 region.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nineteen	nineteen	NUM	CD	NumType=Card	_	_	_	_
5	LTRs	LTRs	NOUN	NNS	Number=Plur	_	_	_	_
6	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	pediatric	pediatric	ADJ	JJ	Degree=Pos	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	average	average	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	33	33	NUM	CD	NumType=Card	_	_	_	_
19	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
20	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	with	with	ADP	IN	_	_	_	_	_
23	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
30	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	455	455	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
37	U3	U3	NUM	CD	NumType=Card	_	_	_	_
38	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3397
# text = Transient expression analyses in cells of neuroglial and lymphocytic origin demonstrated that some of these LTRs had activities which varied significantly from the LAI LTR in U-373 MG cells (an astrocytoma cell line) as well as in Jurkat cells (a CD4-positive lymphocyte cell line).
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	neuroglial	neuroglial	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	some	some	DET	DT	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
17	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	varied	vary	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
25	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	373	373	NUM	CD	NumType=Card	_	_	_	_
30	MG	Mg	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	astrocytoma	astrocytoma	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	as	as	ADV	RB	_	_	_	_	_
39	well	well	ADV	RB	Degree=Pos	_	_	_	_
40	as	as	ADP	IN	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
49	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3398
# text = While LTRs which demonstrated the highest activities in U-373 MG cells also yielded high activities in Jurkat cells, the LTRs were generally more active in Jurkat cells when compared to the LAI LTR.
1	While	while	SCONJ	IN	_	_	_	_	_
2	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	373	373	NUM	CD	NumType=Card	_	_	_	_
12	MG	Mg	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTRs	LTRs	PROPN	NNPS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	generally	generally	ADV	RB	_	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	when	when	ADV	WRB	PronType=Int	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
36	LTR.	LTR.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3399
# text = Differences in LTR sequence also resulted in differences in transcription factor recruitment to cis-acting sites within the U3 region of the LTR, as demonstrated by electrophoretic mobility shift assays.
1	Differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	U3	U3	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
29	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
30	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
31	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3400
# text = In particular, naturally occurring sequence variation impacted transcription factor binding to an activating transcription factor/cAMP response element binding (ATF/CREB) binding site (located between the LEF-1 and distal NF-kappaB transcription factor binding sites) that we identified in previous studies of the HIV-1 LTR.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	naturally	naturally	ADV	RB	_	_	_	_	_
5	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
8	impacted	impact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	LEF	LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	that	that	PRON	WDT	PronType=Rel	_	_	_	_
47	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
48	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
51	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	1	1	NUM	CD	NumType=Card	_	_	_	_
57	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3401
# text = These findings suggest that LTR sequence changes can significantly affect basal LTR function and transcription factor recruitment, which may, in turn, alter the course of viral replication in cells of CNS and immune system origin.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	significantly	significantly	ADV	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	course	course	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	CNS	Cn	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
37	system	system	NOUN	NN	Number=Sing	_	_	_	_
38	origin	origin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3402
# text = Document 003001227 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001227	003001227	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3403
# text = Inhibition of NF-kappa B by sodium salicylate and aspirin [see comments]
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
9	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3404
# text = The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
23	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
32	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
48	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3405
# text = The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	further	further	ADV	RB	_	_	_	_	_
19	explains	explain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	action	action	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3406
# text = This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	therefore	therefore	ADV	RB	_	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3407
# text = Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
1	Sodium	sodium	PROPN	NNP	Number=Sing	_	_	_	_
2	salicylate	salicylate	VERB	VB	VerbForm=Inf	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	aspirin	aspirin	VERB	VB	VerbForm=Inf	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	transfected	transfect	ADJ	JJ	Degree=Pos	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3408
# text = Document 003001228 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001228	003001228	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3409
# text = Costimulation of peripheral blood T cell activation by human endothelial cells.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3410
# text = Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1.
1	Enhanced	enhance	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
16	content	content	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3411
# text = Endothelial cells (EC) act as APC for resting PBL in vitro, and may have important roles in vivo in the pathogenesis of allograft rejection and delayed hypersensitivity.
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	act	act	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	APC	APC	PROPN	NNP	Number=Sing	_	_	_	_
9	for	for	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	_
27	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
30	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3412
# text = We previously reported that human umbilical vein EC provide costimulatory signals to PHA-stimulated PBL via CD2:lymphocyte function-associated Ag-3 and an unidentified ligand pair, resulting in a three- to eight-fold enhancement of IL-2 production.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
7	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
9	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
10	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	CD2	CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
20	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ag	ag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
30	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
31	pair	pair	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	eight	eight	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
42	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3413
# text = The physiologic relevance of this increase was demonstrated by the proliferative advantage provided by EC to PBL suboptimally stimulated with mAb OKT3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
3	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
13	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
18	suboptimally	suboptimally	ADV	RB	_	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
22	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3414
# text = We now report that EC costimulation causes increased levels of IL-2 mRNA as a result of increased IL-2 transcription in PBL.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
7	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	result	result	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3415
# text = We therefore examined the effects of EC on T cell nuclear factors known to regulate IL-2 transcription, including c-jun and c-fos-two components of the transcription factor AP-1, NFAT, and others.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	components	component	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3416
# text = PBL constitutively express c-jun transcripts, and the level of c-jun mRNA is not altered by PHA activation in the absence or presence of EC.
1	PBL	pBl	AUX	MD	VerbForm=Fin	_	_	_	_
2	constitutively	constitutively	ADV	RB	_	_	_	_	_
3	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	PHA	PHa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3417
# text = In contrast, c-fos mRNA is absent from resting T cells and is induced on PHA activation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	PHA	PHa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3418
# text = EC alone do not induce c-fos mRNA but augment the level of c-fos mRNA in PHA-activated
1	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
2	alone	alone	ADV	RB	_	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	augment	augment	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
17	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 3419
# text = T cells by 3- to 10-fold.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3420
# text = This effect is largely independent of the CD2:lymphocyte function-associated Ag-3 pathway.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	largely	largely	ADV	RB	_	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	Ag	ag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3421
# text = Gel-shift analysis reveals the constitutive presence of nuclear factors in resting PBL that bind to the proximal AP-1 site of the IL-2 promoter and that contain immunoreactive c-Jun but not c-Fos protein.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
34	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	c	class	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	Fos	Fos	ADJ	JJ	Degree=Pos	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3422
# text = In contrast, AP-1 from PHA-activated cells contains c-Jun and low levels of c-Fos.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3423
# text = Strikingly, costimulation with EC results in a dramatic increase (up to 15-fold) in the c-Fos content of AP-1.
1	Strikingly	strikingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	up	up	ADP	IN	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
23	content	content	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3424
# text = Levels of other nuclear factors involved in IL-2 regulation were not altered by EC, although NFAT-DNA complexes migrated at a slightly different mobility.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
23	migrated	migrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	slightly	slightly	ADV	RB	_	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3425
# text = In summary, our data suggest that changes in the composition of transcription factor AP-1 is a key molecular mechanism for increasing IL-2 transcription and may underlie the phenomenon of costimulation by EC.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	SCONJ	IN	_	_	_	_	_
24	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3426
# text = Document 003001229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001229	003001229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3427
# text = Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	interferon	interferon	ADP	IN	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3428
# text = We have examined the feasibility of using interferon (IFN) gene transfer as a novel approach to anti-human immunodeficiency virus type 1 (HIV-1) therapy in this study.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	feasibility	feasibility	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3429
# text = To limit expression of a transduced HIV-1 long terminal repeat (LTR)-IFNA2 (the new approved nomenclature for IFN genes is used throughout this article) hybrid gene to the HIV-1-infected cells, HIV-1 LTR was modified.
1	To	to	PART	TO	_	_	_	_	_
2	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	IFNA2	Ifna2	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
21	approved	approve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	nomenclature	nomenclature	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	throughout	throughout	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	article	article	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3430
# text = Deletion of the NF-kappa B elements of the HIV-1 LTR significantly inhibited Tat-mediated transactivation in T-cell lines, as well as in a monocyte line, U937.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	as	as	ADV	RB	_	_	_	_	_
27	well	well	ADV	RB	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
32	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3431
# text = Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 (ISG15), containing the IFN-stimulated response element, partially restored Tat-mediated activation of LTR in T cells as well as in monocytes.
1	Replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	15	15	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ISG15	ISG15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	response	response	NOUN	NN	Number=Sing	_	_	_	_
43	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	partially	partially	ADV	RB	_	_	_	_	_
46	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
56	as	as	ADV	RB	_	_	_	_	_
57	well	well	ADV	RB	Degree=Pos	_	_	_	_
58	as	as	ADP	IN	_	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3432
# text = Insertion of this chimeric promoter (ISG15 LTR) upstream of the human IFNA2 gene directed high levels of IFN synthesis in Tat-expressing cells, while this promoter was not responsive to tumor necrosis factor alpha-mediated activation.
1	Insertion	Insertion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	chimeric	chimeric	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ISG15	ISG15	NUM	CD	NumType=Card	_	_	_	_
8	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	IFNA2	Ifna2	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	PRON	NN	Number=Sing	_	_	_	_
16	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
36	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3433
# text = ISG15-LTR-IFN hybrid gene inserted into the retrovirus vector was transduced into Jurkat and U937 cells.
1	ISG15	ISG15	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
6	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	inserted	insert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	_
12	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3434
# text = Selected transfected clones produced low levels of IFN A (IFNA) constitutively, and their abilities to express interleukin-2 and interleukin-2 receptor upon stimulation with phytohemagglutinin and phorbol myristate acetate were retained.
1	Selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
9	A	a	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	constitutively	constitutively	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	abilities	ability	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	upon	upon	ADP	IN	_	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
34	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
35	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3435
# text = Enhancement of IFNA synthesis observed upon HIV-1 infection resulted in significant inhibition of HIV-1 replication for a period of at least 30 days.
1	Enhancement	Enhancement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	_
4	synthesis	synthesis	PROPN	NNP	Number=Sing	_	_	_	_
5	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	upon	upon	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	period	period	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	at	at	ADV	RB	_	_	_	_	_
25	least	least	ADV	RBS	Degree=Sup	_	_	_	_
26	30	30	NUM	CD	NumType=Card	_	_	_	_
27	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3436
# text = Virus isolated from IFNA-producing cells was able to replicate in the U937 cells but did not replicate efficiently in U937 cells transduced with the IFNA gene.
1	Virus	virus	PROPN	NNP	Number=Sing	_	_	_	_
2	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
20	efficiently	efficiently	ADV	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	_
28	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3437
# text = These results suggest that targeting IFN synthesis to HIV-1-infected cells is an attainable goal and that autocrine IFN synthesis results in a long-lasting and permanent suppression of HIV-1 replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	targeting	targete	VERB	VBG	VerbForm=Ger	_	_	_	_
6	IFN	Ifn	ADP	RP	_	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-infected	-infect	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	attainable	attainable	ADJ	JJ	Degree=Pos	_	_	_	_
17	goal	goal	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
21	IFN	Ifn	ADP	IN	_	_	_	_	_
22	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
23	results	result	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	lasting	lasting	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
31	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3438
# text = Document 003001230 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001230	003001230	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3439
# text = Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-zeta	-zeta	PROPN	NNP	Number=Sing	_	_	_	_
5	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3440
# text = The molecular mechanisms regulating human immunodeficiency virus (HIV) persistence in a major cell reservoir such as the macrophage remain unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3441
# text = NF-kappa B is a transcription factor involved in the regulation of the HIV long terminal repeat and is selectively activated following HIV infection of human macrophages.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	selectively	selectively	ADV	RB	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
24	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3442
# text = Although little information as to what signal transduction pathways mediate NF-kappa B activation in monocytes-macrophages is available, our previous work indicated that classical protein kinase C (PKC) isoenzymes were not involved in the HIV-mediated NF-kappa B activation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
3	information	information	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	to	to	SCONJ	IN	_	_	_	_	_
6	what	what	PRON	WP	PronType=Int	_	_	_	_
7	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	available	available	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
24	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
25	work	work	NOUN	NN	Number=Sing	_	_	_	_
26	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	C	C	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	HIV-	Hiv-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B	b	NOUN	NN	Number=Sing	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3443
# text = In this study, we have focused on atypical PKC isoenzymes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	atypical	atypical	ADJ	JJ	Degree=Pos	_	_	_	_
10	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
11	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3444
# text = PKC-zeta belongs to this family and is known to be an important step in NF-kappa B activation in other cell systems.
1	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
4	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	step	step	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3445
# text = Immunoblotting experiments with U937 cells demonstrate that PKC-zeta is present in these cells, and its expression can be downmodulated by antisense oligonucleotides (AO).
1	Immunoblotting	Immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
25	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	AO	AO	INTJ	UH	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3446
# text = The HIV-mediated NF-kappa B activation is selectively reduced by AO to PKC-zeta.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV-	Hiv-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	AO	AO	PROPN	NNP	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	zeta	zeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3447
# text = In addition, cotransfection of a negative dominant molecule of PKC-zeta (PKC-zeta mut) with NF-kappa B-dependent reporter genes selectively inhibits the HIV- but not phorbol myristate acetate- or lipopolysaccharide-mediated activation of NF-kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
18	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	selectively	selectively	ADV	RB	_	_	_	_	_
30	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	ADV	RB	_	_	_	_	_
36	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
37	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
38	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
49	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3448
# text = That PKC-zeta is specific in regulating NF-kappa B is concluded from the inability of PKC-zeta(mut) to interfere with the basal or phorbol myristate acetate-inducible CREB- or AP1-dependent transcriptional activity.
1	That	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	PKC-zeta	PKC-zeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
30	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
31	acetate	acetate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
32	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
33	CREB	Creb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3449
# text = Lastly, we demonstrate a selective inhibition of p24 production by HIV-infected human macrophages when treated with AO to PKC-zeta.
1	Lastly	Lastly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p24	p24	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	HIV-	HIV-	X	GW	_	_	_	_	SpaceAfter=No
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	AO	AO	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	zeta	zeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3450
# text = Altogether, these results suggest that atypical PKC isoenzymes, including PKC-zeta, participate in the signal transduction pathways by which HIV infection results in the activation of NF-kappa B in human monocytic cells and macrophages.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	atypical	atypical	ADJ	JJ	Degree=Pos	_	_	_	_
8	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
9	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
20	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
21	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	HIV	Hiv	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	results	result	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3451
# text = Document 003001231 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001231	003001231	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3452
# text = Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	persistently	persistently	ADV	RB	_	_	_	_	_
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3453
# text = The mechanisms regulating human immunodeficiency virus (HIV) persistence in human monocytes/macrophages are partially understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3454
# text = Persistent HIV infection of U937 monocytic cells results in NF-kappa B activation.
1	Persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
3	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3455
# text = Whether virus-induced NF-kappa B activation is a mechanism that favors continuous viral replication in macrophages remains unknown.
1	Whether	whether	SCONJ	IN	_	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	favors	favor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3456
# text = To further delineate the molecular mechanisms involved in the activation of NF-kappa B in HIV-infected monocytes and macrophages, we have focused on the regulation of the I kappa B molecules.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
33	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
34	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3457
# text = First, we show that persistent HIV infection results in the activation of NF-kappa
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3458
# text = B not only in monocytic cells but also in macrophages.
1	B	b	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	not	not	ADV	RB	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3459
# text = In HIV-infected cells, I kappa B alpha protein levels are decreased secondary to enhanced protein degradation.
1	In	in	ADP	IN	_	_	_	_	_
2	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3460
# text = This parallels the increased I kappa B alpha synthesis secondary to increased I kappa B alpha gene transcription, i.e., increased RNA and transcriptional activity of its promoter-enhancer.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	parallels	parallel	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	ADV	RB	_	_	_	_	_
9	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3461
# text = Another protein with I kappa B function, p105, is also modified in HIV-infected cells: p105 and p50 steady-state protein levels are increased as a result of increased synthesis and proteolytic processing of p105.
1	Another	another	DET	DT	_	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	p105	p105	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	p50	p50	NUM	CD	NumType=Card	_	_	_	_
22	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	state	state	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	result	result	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3462
# text = Transcriptional activity of p105 is also increased in infected cells and is also mediated by NF-kappa B through a specific kappa B motif.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3463
# text = These results demonstrate the existence of a triple autoregulatory loop in monocytes and macrophages involving HIV, p105 and p50, and MAD3, with the end result of persistent NF-kappa B activation and viral persistence.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	triple	triple	ADJ	JJ	Degree=Pos	_	_	_	_
9	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
15	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p105	p105	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	end	end	NOUN	NN	Number=Sing	_	_	_	_
28	result	result	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
38	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3464
# text = Furthermore, persistent HIV infection of monocytes and macrophages provides a useful model with which to study concomitant modifications of different I kappa B molecules.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
4	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
10	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
13	model	model	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
18	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
19	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3465
# text = Document 003001232 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001232	003001232	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3466
# text = Characterization of 5' end of human thromboxane receptor gene.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	``	_	_	_	_	_
5	end	end	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3467
# text = Organizational analysis and mapping of protein kinase C--responsive elements regulating expression in platelets.
1	Organizational	organizational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
10	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3468
# text = Platelet thromboxane receptors are acutely and reversibly upregulated after acute myocardial infarction.
1	Platelet	Platelet	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	acutely	acutely	ADV	RB	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	reversibly	reversibly	ADV	RB	_	_	_	_	_
8	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
12	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3469
# text = To determine if platelet thromboxane receptors are under transcriptional control, we isolated and characterized human genomic DNA clones containing the 5' flanking region of the thromboxane receptor gene.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	if	if	SCONJ	IN	_	_	_	_	_
4	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
5	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	under	under	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	_
24	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3470
# text = The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	exon	exon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
5	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	's	PUNCT	``	_	_	_	_	_
10	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	thromboxane	thromboxane	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	initially	initially	ADV	RB	_	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	PUNCT	``	_	_	_	_	_
28	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
29	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
30	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
38	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
39	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
40	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
41	that	that	PRON	WDT	PronType=Rel	_	_	_	_
42	extended	extend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
45	141	141	NUM	CD	NumType=Card	_	_	_	_
46	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
47	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
48	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
49	than	than	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	previously	previously	ADV	RB	_	_	_	_	_
52	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
54	placental	placental	NOUN	NN	Number=Sing	_	_	_	_
55	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3471
# text = A major transcription initiation site was located in three human tissues approximately 560 bp upstream from the translation initiation codon and 380 bp upstream from any previously identified transcription initiation site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	560	560	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
19	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
20	codon	codon	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	380	380	NUM	CD	NumType=Card	_	_	_	_
23	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
24	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	any	any	DET	DT	_	_	_	_	_
27	previously	previously	ADV	RB	_	_	_	_	_
28	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3472
# text = The thromboxane receptor gene has neither a TATA nor a CAAT consensus site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	neither	neither	CCONJ	CC	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3473
# text = Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/chloramphenicol acetyltransferase (CAT) chimera plasmids into platelet-like K562 cells.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	_
7	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
25	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
30	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
31	into	into	ADP	IN	_	_	_	_	_
32	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	like	like	INTJ	UH	_	_	_	_	_
35	K562	K562	NUM	CD	NumType=Card	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3474
# text = Thromboxane receptor promoter activity, as assessed by CAT expression, was relatively weak but was significantly enhanced by phorbol ester treatment.
1	Thromboxane	Thromboxane	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	as	as	SCONJ	IN	_	_	_	_	_
7	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	relatively	relatively	ADV	RB	_	_	_	_	_
14	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3475
# text = Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester-responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 (AP-2) binding consensus sites located approximately 1.8 kb
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	PUNCT	``	_	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	K562	K562	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
14	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
15	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
16	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
45	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
46	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	approximately	approximately	ADV	RB	_	_	_	_	_
48	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
49	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3476
# text = 5' from the transcription initiation site.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3477
# text = These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2-like nuclear factor binding to upstream promoter elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	_
16	end	end	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	C	c	NOUN	NN	Number=Sing	_	_	_	_
38	via	via	ADP	IN	_	_	_	_	_
39	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	like	like	ADP	IN	_	_	_	_	_
47	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
49	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
53	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3478
# text = These findings strongly suggest that the mechanism for previously described upregulation of platelet thromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in platelet-progenitor cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
14	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
15	receptors	receptor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
18	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
19	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	thromboxane	thromboxane	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3479
# text = Document 003001233 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001233	003001233	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3480
# text = The effect of Toremifene on the expression of some genes in human mononuclear cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Toremifene	Toremifene	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3481
# text = Toremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells.
1	Toremifene	Toremifene	PRON	PRP	_	_	_	_	_
2	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	varied	varied	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3482
# text = After short-term, in vitro exposure to therapeutical levels, distinct changes in P-glycoprotein, steroid receptors, p53 and Bcl-2 expression take place.
1	After	after	ADP	IN	_	_	_	_	_
2	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	term	term	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	therapeutical	therapeutical	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
20	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p53	p53	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	take	take	NOUN	NN	Number=Sing	_	_	_	_
29	place	place	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3483
# text = In view of the increasing use of antiestrogens in cancer therapy and prevention, there is obvious merit in long-term in vivo studies to be conducted.
1	In	in	ADP	IN	_	_	_	_	_
2	view	view	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	antiestrogens	antiestrogen	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
11	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	there	there	PRON	EX	_	_	_	_	_
16	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
18	merit	merit	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	term	term	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
25	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3484
# text = Document 003001234 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001234	003001234	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3485
# text = Role of HIV-1 Nef expression in activation pathways in CD4+ T cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	Nef	Nef	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3486
# text = The role of the human immunodeficiency virus (HIV-1) Nef protein in T cell activation pathways was investigated using a Jurkat CD4+ cell line stably transfected with a Nef expression vector.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	stably	stably	ADV	RB	_	_	_	_	_
30	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3487
# text = Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA-binding activity of NF-kappa B and AP-1 (Fos/Jun) complex in response to phorbol myristate acetate, TNF-alpha, or immobilized antibodies to CD3 were monitored.
1	Secretion	Secretion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
42	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
43	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	or	or	CCONJ	CC	_	_	_	_	_
50	immobilized	immobilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
54	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3488
# text = These parameters were not modified by Nef expression in Jurkat cells, whereas stimulation with the same stimuli resulted in partial inhibition of LTR activation in Nef+ Jurkat cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
19	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	+	+	SYM	SYM	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3489
# text = This inhibition was not mediated through Nef phosphorylation on Thr-15 or GTP-binding activity because mutations in critical sites did not alter this inhibition.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	Thr	Thr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-15	-15	NUM	CD	NumType=Card	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	GTP	Gtp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	because	because	SCONJ	IN	_	_	_	_	_
18	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	alter	alter	ADV	RB	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3490
# text = Analysis of truncated LTRs confirmed that inhibition of LTR activation was not mediated through NF-kappa B-binding activity but through the region containing the negative responding elements (NREs).
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	LTRs	LTRs	NOUN	NNS	Number=Plur	_	_	_	_
5	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	responding	responding	NOUN	NN	Number=Sing	_	_	_	_
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NREs	NREs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3491
# text = These results suggest that Nef downmodulates LTR activation without significantly inhibiting the capacity of T cells to respond to immunological activations.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
6	downmodulates	downmodulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LTR	LTR	ADJ	JJR	Degree=Cmp	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	without	without	SCONJ	IN	_	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
21	activations	activation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3492
# text = Document 003001235 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001235	003001235	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3493
# text = Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3494
# text = Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells.
1	Recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	extravasation	extravasation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
12	barrier	barrier	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	favored	favore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	SCONJ	IN	_	_	_	_	_
22	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3495
# text = Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T lymphocytes into various organs, we have looked for the profile of adhesion molecules expressed by HTLV-1-transformed T cells.
1	Since	since	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
4	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
5	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	X	LS	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	into	into	ADP	IN	_	_	_	_	_
33	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
34	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
37	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	looked	look	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
45	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	T	t	PROPN	NNP	Number=Sing	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3496
# text = Flow cytometry analysis indicated that these cells were expressing high levels of vascular cell adhesion molecule 1 (VCAM-1 [CD106]), a 110-kDa member of the immunoglobulin gene superfamily, first identified on endothelial cells stimulated with inflammatory cytokines.
1	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	expressing	expresse	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
16	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CD106	CD106	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	110	110	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-kDa	-kDa	NOUN	NN	Number=Sing	_	_	_	_
30	member	member	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	first	first	ADV	RB	_	_	_	_	_
38	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
45	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3497
# text = This adhesion molecule was also expressed by T cells obtained from one patient with HTLV-1-associated myelopathy/tropical spastic paraparesis but not by activated T cells isolated from one normal blood donor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	myelopathy	myelopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	tropical	tropical	ADJ	JJ	Degree=Pos	_	_	_	_
23	spastic	spastic	ADJ	JJ	Degree=Pos	_	_	_	_
24	paraparesis	paraparesis	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3498
# text = The role of the viral trans-activator Tax protein in the induction of VCAM-1 was first indicated by the detection of this adhesion molecule on Jurkat T-cell clones stably expressing the tax gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	first	first	ADV	RB	_	_	_	_	_
20	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
33	stably	stably	ADV	RB	_	_	_	_	_
34	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3499
# text = The effect of Tax on VCAM-1 gene transcription was next confirmed in JPX-9 cells, a subclone of Jurkat cells, carrying the tax sequences under the control of an inducible promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	next	next	ADV	RB	_	_	_	_	_
13	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	JPX	JPX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	9	9	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
30	under	under	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3500
# text = Furthermore, deletion and mutation analyses of the VCAM-1 promoter performed with chloramphenicol acetyltransferase constructs revealed that Tax was trans activating the VCAM-1 promoter via two NF-kappaB sites present at bp -72 and -57 in the VCAM-1 gene promoter, with both of them being required for the Tax-induced expression of this adhesion molecule.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
16	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
17	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
18	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
23	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	via	via	ADP	IN	_	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	72	72	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	57	57	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	both	both	DET	DT	_	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
55	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
56	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
65	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
66	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3501
# text = Finally, gel mobility shift assays demonstrated the nuclear translocation of proteins specifically bound to these two NF-kappaB motifs, confirming that VCAM-1 was induced on Tax-expressing cells in a kappaB-dependent manner.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3502
# text = Collectively, these results therefore suggest that the exclusive Tax-induced expression of VCAM-1 on T cells may represent a pivotal event in the progression of HTLV-1-associated diseases.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	_
6	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
10	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
25	event	event	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3503
# text = Document 003001236 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001236	003001236	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3504
# text = Rel/NF-kappa B transcription factors and the control of apoptosis.
1	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3505
# text = The process of apoptosis is used to eliminate unwanted cells from a wide variety of organisms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	eliminate	eliminate	VERB	VB	VerbForm=Inf	_	_	_	_
9	unwanted	unwanted	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
14	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3506
# text = Various extracellular signals, often converging in common intracellular pathways, can induce apoptosis in a cell-type-specific fashion.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	often	often	ADV	RB	_	_	_	_	_
6	converging	converge	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	type-	type-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3507
# text = Recent work from several laboratories has demonstrated that Rel/NF-kappa B transcription factors regulate apoptosis in many cell types.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	laboratories	laboratory	NOUN	NNS	Number=Plur	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3508
# text = In most cells, Rel/NF-kappa B transcription factors appear to mediate survival signals that protect cells from apoptosis; however, under some circumstances, activation of these factors may also promote apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	protect	protect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	some	some	DET	DT	_	_	_	_	_
28	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
37	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3509
# text = Document 003001237 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001237	003001237	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3510
# text = Reactive oxygen species and antioxidants in inflammatory diseases.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
3	species	species	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3511
# text = This paper aims to review the role of free radical-induced tissue damage and antioxidant defence mechanisms in inflammatory diseases that involve pathogenic processes similar to the periodontal diseases.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
3	aims	aim	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	review	review	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
10	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
14	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
17	defence	defence	NOUN	NN	Number=Sing	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
25	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
26	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	periodontal	periodontal	ADJ	JJ	Degree=Pos	_	_	_	_
30	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3512
# text = There is a clearly defined and substantial role for free radicals or reactive oxygen species (ROS) in periodontitis, but little research has been performed in this area.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	clearly	clearly	ADV	RB	_	_	_	_	_
5	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
11	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	periodontitis	periodontitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	research	research	NOUN	NN	Number=Sing	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3513
# text = This paper reviews the considerable data available relating ROS activity and antioxidant defence to inflammatory diseases and attempts to draw parallels with periodontitis, in an effort to stimulate more periodontal research in this important area.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
3	reviews	review	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
6	data	data	NOUN	NN	Number=Sing	_	_	_	_
7	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
8	relating	relat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	ROS	Ros	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
13	defence	defence	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	attempts	attempt	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	draw	draw	VERB	VB	VerbForm=Inf	_	_	_	_
21	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	periodontitis	periodontitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	effort	effort	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
30	more	more	ADV	RBR	_	_	_	_	_
31	periodontal	periodontal	ADJ	JJ	Degree=Pos	_	_	_	_
32	research	research	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
36	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3514
# text = The recent discovery of the transcription factor nuclear factor kappa B (NF-kappa B) is reviewed and several potential pathways for cytokine-induced periodontal tissue damage, mediated by NF-kappa B1 are discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	discovery	discovery	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	reviewed	review	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	periodontal	periodontal	ADJ	JJ	Degree=Pos	_	_	_	_
29	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
30	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3515
# text = Emphasis is placed on cytokines that have been studied in periodontitis, principally TNF-alpha, IL-1, IL-6, IL-8 and beta-interferon.
1	Emphasis	Emphasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	placed	place	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	periodontitis	periodontitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	principally	principally	ADV	RB	_	_	_	_	_
14	TNF	Tnf	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	IL	il	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3516
# text = The link between cellular production of such important mediators of inflammation and the antioxidant (AO) thiols, cysteine and reduced glutathione (GSH), is discussed and it is hypothesised that NF-kappa B antagonists may offer important therapeutic benefits.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	link	link	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	AO	AO	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	thiols	thiol	INTJ	UH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	cysteine	cysteine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	discussed	discussed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	hypothesised	hypothesise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
40	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
41	offer	offer	VERB	VB	VerbForm=Inf	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
44	benefits	benefit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3517
# text = Document 003001238 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001238	003001238	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3518
# text = A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	p50/p105	p50/p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3519
# text = A Rel-related, mitogen-inducible, kappa B-binding protein has been cloned as an immediate-early activation gene of human peripheral blood T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	Rel-related	Rel-related	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mitogen	mitogen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3520
# text = The cDNA has an open reading frame of 900 amino acids capable of encoding a 97-kDa protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
6	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
7	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	900	900	NUM	CD	NumType=Card	_	_	_	_
10	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
11	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
12	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	97	97	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3521
# text = This protein is most similar to the 105-kDa precursor polypeptide of p50-NF-kappa B.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
12	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3522
# text = Like the 105-kDa precursor, it contains an amino-terminal Rel-related domain of about 300 amino acids and a carboxy-terminal domain containing six full cell cycle or ankyrin repeats.
1	Like	like	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
6	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	Rel-	rel-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	about	about	ADV	RB	_	_	_	_	_
19	300	300	NUM	CD	NumType=Card	_	_	_	_
20	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
21	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	six	six	NUM	CD	NumType=Card	_	_	_	_
30	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
35	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3523
# text = In vitro-translated proteins, truncated downstream of the Rel domain and excluding the repeats, bind kappa B sites.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	excluding	exclude	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3524
# text = We refer to the kappa B-binding, truncated protein as p50B by analogy with p50-NF-kappa B and to the full-length protein as p97.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	refer	refer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	p50B	p50b	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	analogy	analogy	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	length	length	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	p97.	p97.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3525
# text = p50B is able to form heteromeric kappa B-binding complexes with RelB, as well as with p65 and p50, the two subunits of NF-kappa B. Transient-transfection experiments in embryonal carcinoma cells demonstrate a functional cooperation between p50B and RelB or p65 in transactivation of a reporter plasmid dependent on a kappa B site.
1	p50B	p50b	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
6	heteromeric	heteromeric	ADJ	JJ	Degree=Pos	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	RelB	Relb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
31	Transient	Transient	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
34	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	embryonal	embryonal	ADJ	JJ	Degree=Pos	_	_	_	_
37	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
42	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
43	between	between	ADP	IN	_	_	_	_	_
44	p50B	p50b	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
54	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	on	on	ADP	IN	_	_	_	_	_
57	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3526
# text = The data imply the existence of a complex family of NF-kappa B-like transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3527
# text = Document 003001239 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001239	003001239	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3528
# text = MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells.
1	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3529
# text = TCR engagement stimulates the activation of the protein kinase Raf-1.
1	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
2	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3530
# text = Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases, ERK1 and ERK2.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	phosphorylates	phosphorylate	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
32	phosphorylates	phosphorylate	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
37	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
41	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	ERK1	Erk1	PROPN	NNP	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	ERK2	Erk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3531
# text = Raf-1 activity promotes IL-2 production in activated T lymphocytes.
1	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3532
# text = Therefore, we sought to determine whether MEK1 and ERK activities also stimulate IL-2 gene transcription.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	ERK	Erk	PROPN	NNP	Number=Sing	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3533
# text = Expression of constitutively active Raf-1 or MEK1 in Jurkat T cells enhanced the stimulation of IL-2 promoter-driven transcription stimulated by a calcium ionophore and PMA, and together with a calcium ionophore the expression of each protein was sufficient to stimulate NF-AT activity.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	MEK1	MEK1	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
29	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	together	together	ADV	RB	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
38	ionophore	ionophore	SCONJ	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	each	each	DET	DT	_	_	_	_	_
43	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
48	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
51	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3534
# text = Expression of MEK1-interfering mutants inhibited the stimulation of IL-2 promoter-driven transcription and blocked the ability of constitutively active Ras and Raf-1 to costimulate NF-AT activity with a calcium ionophore.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MEK1	MEK1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	constitutively	constitutively	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	Ras	Ras	PROPN	NNPS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	costimulate	costimulate	VERB	VB	VerbForm=Inf	_	_	_	_
32	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
39	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3535
# text = Expression of the MAP kinase-specific phosphatase, MKP-1, which blocks ERK activation, inhibited IL-2 promoter and NF-AT-driven transcription stimulated by a calcium ionophore and PMA, and in addition, MKP-1 neutralized the transcriptional enhancement caused by active Raf-1 and MEK1 expression.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	MKP	MKP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
35	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	MKP	MKP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	neutralized	neutralize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
50	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
53	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	MEK1	MEK1	NUM	CD	NumType=Card	_	_	_	_
58	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3536
# text = We conclude that the MAP kinase signal transduction pathway consisting of Raf-1, MEK1, and ERK1 and ERK2 functions in the stimulation IL-2 gene transcription in activated T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ERK1	ERK1	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	ERK2	ERK2	NUM	CD	NumType=Card	_	_	_	_
22	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3537
# text = Document 003001240 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001240	003001240	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3538
# text = Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB.
1	Tpl	Tpl	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-2	-2	NUM	CD	NumType=Card	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3539
# text = The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tpl	Tpl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3540
# text = Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
39	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
47	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
48	that	that	PRON	WDT	PronType=Rel	_	_	_	_
49	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
51	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3541
# text = We, therefore, conclude that signals generated by the convergence of the MAPK and the calcineurin/NFAT pathway are necessary and sufficient for the activation of the IL-2 promoter by Tpl-2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	conclude	conclude	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	convergence	convergence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3542
# text = The activation of both the IL-2 promoter and an NFAT-driven minimal promoter were shown to depend on signals transduced by Raf1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
23	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	Raf1	Raf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3543
# text = However, it was only the IL-2 promoter whose activation by Tpl-2 was fully blocked by the dominant negative mutant MEK1S218/222A and the MEK1/MEK2 inhibitor PD098059.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	fully	fully	ADV	RB	_	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
24	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
25	MEK1S218/222A	MEK1S218/222a	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	MEK1	Mek1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	MEK2	MEK2	NUM	CD	NumType=Card	_	_	_	_
31	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
32	PD098059	PD098059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3544
# text = Since the activation of NFAT is MAPK-dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
12	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	either	either	CCONJ	CC	_	_	_	_	_
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	partially	partially	ADV	RB	_	_	_	_	_
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	MEK1	Mek1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	MEK2	Mek2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3545
# text = In addition, they suggested that the activation of the IL-2 promoter is under the control of not only NFAT but also a second factor whose activation is MEK-dependent.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	NFAT	Nfat	ADV	RB	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	MEK	Mek	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3546
# text = Experiments in COS-1 and EL-4 cells confirmed both hypotheses and revealed that the second factor activated by Tpl-2 is NF-kappaB.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	EL	EL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	hypotheses	hypothese	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3547
# text = While the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418, it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2-mediated NFAT activation is under the control of a combination of calcineurin-dependent and independent pathways.
1	While	while	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	fully	fully	ADV	RB	_	_	_	_	_
23	blocked	blocked	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
29	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	_
30	delta418	delta418	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	partially	partially	ADV	RB	_	_	_	_	_
36	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
40	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
41	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
42	A	a	NOUN	NN	Number=Sing	_	_	_	_
43	suggesting	suggesting	VERB	VBG	VerbForm=Ger	_	_	_	_
44	that	that	SCONJ	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	Tpl	Tpl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
52	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
53	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	under	under	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	control	control	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
66	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3548
# text = Both pathways were fully blocked by Bcl-2 or Bcl-X(L).
1	Both	both	DET	DT	_	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	fully	fully	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3549
# text = Document 003001241 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001241	003001241	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3550
# text = Regulation of cytokine and cytokine receptor expression by glucocorticoids.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3551
# text = Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttranscriptional levels.
1	Glucocorticoids	Glucocorticoid	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	GCS	GCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	profoundly	profoundly	ADV	RB	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
13	largely	largely	ADV	RB	_	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3552
# text = GCS were also reported to act indirectly by inducing transforming growth factor-beta expression, which in turn blocks T cell immunity.
1	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
7	indirectly	indirectly	ADV	RB	_	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
20	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3553
# text = In exerting their antiproliferative effects, GCS diffuse into target cells where they bind their cytoplasmic receptor, which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements (GRE), which are located in the promoter region of cytokine genes or, alternatively, through antagonism of the action of transcription factors required for optimal transcriptional activation.
1	In	in	SCONJ	IN	_	_	_	_	_
2	exerting	exert	VERB	VBG	VerbForm=Ger	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	_
8	diffuse	diffuse	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	target	target	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	where	where	ADV	WRB	PronType=Int	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
22	translocates	translocate	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
26	where	where	ADV	WRB	PronType=Rel	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
28	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
51	region	region	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
55	or	or	CCONJ	CC	_	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	alternatively	alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	through	through	ADP	IN	_	_	_	_	_
60	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	action	action	NOUN	NN	Number=Sing	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
66	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
67	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	for	for	ADP	IN	_	_	_	_	_
69	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
70	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
71	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3554
# text = In contrast to their inhibitory effects on cytokine expression, GCS up-regulate cytokine receptor expression that correlates with enhanced cytokine effects on target cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GCS	GCS	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	target	target	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3555
# text = In this review, we summarize the current state of knowledge of the mechanism of action of GCS, including the phenomenon of steroid-induced rebound, which ensues upon GCS withdrawal.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	summarize	summarize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
9	state	state	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	action	action	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GCS	GCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	rebound	rebound	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	ensues	ensue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	upon	upon	ADP	IN	_	_	_	_	_
32	GCS	GCS	PROPN	NNP	Number=Sing	_	_	_	_
33	withdrawal	withdrawal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3556
# text = Document 003001242 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001242	003001242	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3557
# text = Selenium-mediated inhibition of transcription factor NF-kappa B and HIV-1 LTR promoter activity.
1	Selenium-	Selenium-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3558
# text = The eukaryotic transcription factor NF-kappa B is involved in the inducible expression of various inflammatory genes as well as in HIV-1 replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	well	well	ADV	RB	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3559
# text = Activation of NF-kappa B is induced by prooxidants and several stimuli eliciting oxidative stress, such as cytokines, lipopolysaccharide, UV irradiation and other mediators.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	prooxidants	prooxidant	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
14	eliciting	elicit	VERB	VBG	VerbForm=Ger	_	_	_	_
15	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
16	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
25	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3560
# text = Various antioxidants inhibit NF-kappa B activation in response to these stimuli.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3561
# text = In this study, we have investigated the effects of selenium, an integral component of glutathione peroxidase (GPX), on NF-kappa B activation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
18	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GPX	GPX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3562
# text = In selenium-deprived Jurkat and ESb-L
1	In	in	ADP	IN	_	_	_	_	_
2	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	deprived	deprive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	ESb	ESb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	L	L	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3563
# text = T lymphocytes, supplementation of selenium led to a substantial increase of GPX activity.
1	T	t	NOUN	NN	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	_
7	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GPX	GPX	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3564
# text = Analysis of DNA binding revealed that NF-kappa B activation in response to TNF was significantly inhibited under these conditions.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	under	under	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3565
# text = Likewise, reporter gene assays using luciferase constructs driven by the HIV-1 long terminal repeat showed a dose-dependent inhibition of NF-kappa B controlled gene expression by selenium.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
9	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	controlled	control	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3566
# text = The effects of selenium were specific for NF-kappa B, since the activity of the transcription factor AP-1 was not suppressed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3567
# text = These data suggest that selenium supplementation may be used to modulate the expression of NF-kappa B target genes and HIV-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	_
6	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3568
# text = Document 003001243 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001243	003001243	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3569
# text = Soluble factors secreted by activated T-lymphocytes modulate the transcription of the immunosuppressive cytokine TGF-beta 2 in glial cells.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3570
# text = Coordination of the immune response to injury or disease in the brain is postulated to involve bi-directional discourse between the immune system and the central nervous system.
1	Coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
17	bi-directional	bi-directional	ADJ	JJ	Degree=Pos	_	_	_	_
18	discourse	discourse	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
26	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3571
# text = This cross communication involves soluble mediators, including various growth factors, cytokines, and neuropeptides.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	_
3	communication	communication	NOUN	NN	Number=Sing	_	_	_	_
4	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	neuropeptides	neuropeptide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3572
# text = In this report, we demonstrate that the supernatant from activated T-lymphocytes is able to induce the transcription of a potent cytokine, TGF-beta 2 in glial cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3573
# text = The activating stimulus invokes signaling mechanisms distinct from known kinase or protease pathways.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
3	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
4	invokes	invoke	NOUN	NNS	Number=Plur	_	_	_	_
5	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3574
# text = Activation of TGF-beta 2 transcription correlates with the loss of binding activity for an 80 kDA glial labile repressor protein, GLRP, to a responsive region within the TFG-beta 2 promoter.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	80	80	NUM	CD	NumType=Card	_	_	_	_
18	kDA	kDa	NOUN	NN	Number=Sing	_	_	_	_
19	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
20	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
21	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	GLRP	GLRP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	_
30	within	within	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	TFG	Tfg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3575
# text = Although GLRP shares some characteristics with the inducible transcription factor AP-1, it appears to be distinct from known AP-1 family members.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	GLRP	GLRP	PROPN	NNP	Number=Sing	_	_	_	_
3	shares	share	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	some	some	DET	DT	_	_	_	_	_
5	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3576
# text = These data along with previous observations demonstrating the potent immunosuppressive activity of TGF-beta 2, support a model for a feedback mechanism between the activated T-lymphocytes and astrocytes via TGF-beta 2 to regulate the immune response.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	along	along	ADV	RB	_	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
6	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrating	demonstrate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
10	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	model	model	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	between	between	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	via	via	ADP	IN	_	_	_	_	_
33	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
41	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3577
# text = Document 003001244 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001244	003001244	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3578
# text = Distinct DNase-I hypersensitive sites are associated with TAL-1 transcription in erythroid and T-cell lines.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	TAL	Tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3579
# text = The tal-1 gene, frequently activated in human T-cell acute lymphoblastic leukemia (T-ALL), is expressed in the erythroid, megakaryocytic, and mast cell lineages during normal hematopoiesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	frequently	frequently	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	ALL	All	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	mast	mast	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
34	during	during	ADP	IN	_	_	_	_	_
35	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
36	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3580
# text = To gain further insight into the molecular mechanisms that control tal-1 expression, we investigated tal-1 chromatin structure in erythroid/megakaryocytic cell lines and in T-cell lines either with or without tal-1 rearrangements.
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	insight	insight	ADV	RB	_	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
22	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
34	either	either	CCONJ	CC	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	without	without	ADP	IN	_	_	_	_	_
38	tal	tal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3581
# text = Tal-1 transcription was shown to be monoallelic in Jurkat, a T-cell line that expresses tal-1 in the absence of apparent genomic alteration of the locus.
1	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	expresses	express	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	tal	tal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
27	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
28	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3582
# text = Methylation studies indicated that the tal-15' GC-rich region behaves like a CpG island, hypomethylated in normal cells, and methylated de novo on transcriptionally inactive alleles in established cell lines.
1	Methylation	Methylation	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tal	tal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-15	-15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	``	_	_	_	_	_
9	GC	Gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	behaves	behave	NOUN	NNS	Number=Plur	_	_	_	_
14	like	like	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
17	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	hypomethylated	hypomethylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	methylated	methylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	de	de	X	FW	Foreign=Yes	_	_	_	_
27	novo	novo	ADV	RB	_	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
30	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
31	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3583
# text = Five major DNase-I hypersensitive sites (HS) were mapped in the tal-1 locus.
1	Five	five	NUM	CD	NumType=Card	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HS	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3584
# text = HS I, IV, and V were exclusively observed in the erythroid/megakaryocytic cell lines that express tal-1 from the promoters 1a and 1b.
1	HS	h	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IV	iv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	V	V	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	exclusively	exclusively	ADV	RB	_	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	a	a	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3585
# text = HS II was weak in hematopoietic cell lines, absent in Hela, and greatly enhanced in Jurkat, suggesting that this region might be implicated in the cis-activation of tal-1 promoter 1b in this cell line.
1	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
2	II	II	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Hela	Hela	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	greatly	greatly	ADV	RB	_	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cis-activation	cis-activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	b	b	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3586
# text = HS III was weak in HEL and Jurkat, and greatly enhanced in DU528, a T-cell line that bears a t (1;14) and initiates tal-1 transcription within exon 4.
1	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
2	III	III	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HEL	HEL	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	greatly	greatly	ADV	RB	_	_	_	_	_
12	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DU528	DU528	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	bears	bear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	t	t	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1;14	1;14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
35	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3587
# text = These results suggest that distinct regulatory elements are associated with the use of the different tal-1 promoters.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	use	use	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3588
# text = Document 003001245 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001245	003001245	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3589
# text = The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	sis/	sisith	SYM	SYM	_	_	_	_	SpaceAfter=No
19	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
32	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3590
# text = Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as one possible mechanism of cellular transformation by human T-cell leukemia virus type 1.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	sis/	sis/	SYM	NFP	_	_	_	_	SpaceAfter=No
9	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PDGF	Pdgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	proto	proto	PART	TO	_	_	_	_	SpaceAfter=No
22	-oncogene	-oncogene	VERB	VB	VerbForm=Inf	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
33	type	type	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	one	one	NUM	CD	NumType=Card	_	_	_	_
40	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
41	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
44	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
50	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
51	type	type	NOUN	NN	Number=Sing	_	_	_	_
52	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3591
# text = In previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive element 1 (TRE1), necessary for transactivation by Tax.
1	In	in	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	c-sis/PDGF	c-sis/pdgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TRE1	TRE1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3592
# text = We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Sp3	Sp3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	TRE1	TRE1	PROPN	NNP	Number=Sing	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
27	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
28	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3593
# text = In the present work, we have investigated the mechanism(s) whereby Tax transactivates the c-sis/PDGF-B proto-oncogene.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	s	s	X	AFX	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	whereby	whereby	ADJ	JJ	Degree=Pos	_	_	_	_
15	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
16	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	c-sis/PDGF	c-sis/pdgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	proto-oncogene	proto-oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3594
# text = In vitro transcription assays showed that Tax was able to significantly increase the transcriptional activity of a template containing the -257 to +74 region of the c-sis/PDGF-B promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	template	template	NOUN	NN	Number=Sing	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	257	257	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
25	74	74	NUM	CD	NumType=Card	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	c-sis/PDGF-B	c-sis/pdgf-b	ADJ	JJ	Degree=Pos	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3595
# text = Electrophoretic mobility shift assay analysis showed that Tax increased the DNA binding activity of both Sp1 and NGFI-A/Egr-1 using a TRE1 probe.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	TRE1	tRE1	NUM	CD	NumType=Card	_	_	_	_
28	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3596
# text = Analysis of Tax mutants showed that two mutants, IEXC29S and IEXL320G, were unable to significantly transactivate the c-sis/PDGF-B promoter.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IEXC29	IEXC29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	S	S	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IEXL320G	IEXL320G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	c-sis/PDGF	c-sis/pdgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3597
# text = Finally, co-immunoprecipitation analysis revealed that Tax is able to stably bind to both Sp1 and NGFI-A/Egr-1.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	co-immunoprecipitation	co-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	stably	stably	ADV	RB	_	_	_	_	_
12	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3598
# text = Interestingly, co-immunoprecipitation analysis also revealed that Tax mutant IEXC29S is unable to interact with NGFI-A/Egr-1, whereas Tax mutant IEXL320G is able to interact with NGFI-A/Egr-1.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	co-immunoprecipitation	co-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
9	mutant	mutant	PROPN	NNP	Number=Sing	_	_	_	_
10	IEXC29	IEXC29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	S	S	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
27	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
28	IEXL320G	Iexl320g	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3599
# text = Document 003001246 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001246	003001246	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3600
# text = Effects of CD45 on NF-kappa B.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3601
# text = Implications for replication of HIV-1.
1	Implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3602
# text = Increased levels of replication of the HIV type 1 are observed after the activation of infected T cells through the TCR.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3603
# text = However, anti-CD45 antibodies inhibit these effects in cells from infected individuals.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-CD45	anti-CD45	NUM	CD	NumType=Card	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3604
# text = In this study, we examined interrelationships between CD45 and HIV-1 further.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	interrelationships	interrelationship	NOUN	NNS	Number=Plur	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	further	further	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3605
# text = We measured effects on the HIV-1 LTR in T cell lines that were stimulated with antibodies against CD45 and in those that lacked the expression of CD45 on their surfaces.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
19	against	against	ADP	IN	_	_	_	_	_
20	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3606
# text = First, anti-CD45 antibodies did not affect basal but decreased activated levels of expression from the HIV-1 LTR.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-CD45	anti-CD45	NUM	CD	NumType=Card	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
8	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	LTR.	LTR.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3607
# text = Second, T cells, which lack CD45 and cannot signal via the TCR, supported higher levels of viral replication and gene expression.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	CD45	Cd45	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
11	not	not	PART	RB	_	_	_	_	_
12	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3608
# text = This was due to the presence of active NF-kappa B complexes in the nucleus of CD45- T cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3609
# text = Additionally, infected T cells displayed lower levels of CD45 on their surfaces.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3610
# text = Thus, CD45 plays an active role in the physiology of T cells and in the replication of HIV-1.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3611
# text = Document 003001247 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001247	003001247	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3612
# text = Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.
1	Astrocytes	Astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	glioblastoma	glioblastoma	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3613
# text = The 'octamer' sequence, ATGCAAAT or its complement ATTTGCAT, is a key element for the transcriptional regulation of immunoglobulin genes in B-lymphocytes as well as a number of housekeeping genes in all cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
3	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	'	'	PUNCT	''	_	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ATGCAAAT	Atgcaaat	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
11	ATTTGCAT	Atttgcat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	as	as	ADV	RB	_	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	number	number	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	housekeeping	housekeeping	NOUN	NN	Number=Sing	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	all	all	DET	DT	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3614
# text = In lymphocytes, the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression, while the ubiquitous protein Oct-1 seems to control general octamer site-dependent transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	octamer-binding	octamer-binding	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	Oct-2	Oct-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
11	thereof	thereof	CCONJ	CC	Typo=Yes	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	while	while	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
35	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
36	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3615
# text = Various other genes, for example interleukin-1 and MHC class II genes, contain an octamer sequence in the promoter and are expressed in cells of both the immune and nervous systems.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	example	example	NOUN	NN	Number=Sing	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	both	both	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
34	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3616
# text = This prompted us to analyze the octamer-binding proteins in the latter cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3617
# text = Using the electrophoretic mobility shift assay, at least six novel octamer binding proteins were detected in nuclear extracts of cultured mouse astrocytes.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	at	at	ADV	RB	_	_	_	_	_
9	least	least	ADV	RBS	Degree=Sup	_	_	_	_
10	six	six	NUM	CD	NumType=Card	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3618
# text = These proteins are differentially expressed in human glioblastoma and neuroblastoma cell lines.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	differentially	differentially	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	glioblastoma	glioblastoma	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3619
# text = The nervous system-derived (N-Oct) proteins bound to the octamer DNA sequence in a manner which is indistinguishable from the Oct-1 and Oct-2A proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3620
# text = The relationship of the N-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and Oct-2A proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	clipping	clipping	NOUN	NN	Number=Sing	_	_	_	_
20	bandshift	bandshift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
26	towards	towards	ADP	IN	_	_	_	_	_
27	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	_
28	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	against	against	ADP	IN	_	_	_	_	_
30	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-1	-1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3621
# text = On the basis of these assays, all N-Oct-factors were found to be distinct from the ubiquitous Oct-1 and the lymphoid-specific Oct-2A proteins.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
22	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	A	a	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3622
# text = In melanoma cells that contain the N-Oct-3 factor, a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an Oct-2A expression vector.
1	In	in	ADP	IN	_	_	_	_	_
2	melanoma	melanoma	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	neither	neither	ADV	RB	_	_	_	_	_
21	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	nor	nor	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	upon	upon	ADP	IN	_	_	_	_	_
27	contransfection	contransfection	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3623
# text = We therefore speculate that N-Oct-3 and other N-Oct factors have a specific role in gene expression in cells of the nervous system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3624
# text = Document 003001248 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001248	003001248	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3625
# text = CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3626
# text = CD40 is an important signaling and activation
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3627
# text = Ag found on certain bone marrow-derived cells.
1	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
5	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
6	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3628
# text = Recently, CD40 also has been shown to be expressed by mesenchymal cells, including human fibroblasts.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	mesenchymal	mesenchymal	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3629
# text = Little is known about the role of CD40 in fibroblasts.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	about	about	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3630
# text = The current study investigates the hypothesis that CD40 expressed on lung fibroblasts is an activation structure and mechanism for interaction with hemopoietic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	investigates	investigate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3631
# text = Communication between resident tissue fibroblasts and T cells is necessary for normal wound healing, and can be pathologic, resulting in tissue fibrosis.
1	Communication	communication	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	resident	resident	ADJ	JJ	Degree=Pos	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	T	t	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	wound	wound	NOUN	NN	Number=Sing	_	_	_	_
14	healing	healing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	pathologic	pathologic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
24	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3632
# text = Signaling through CD40 with soluble CD40 ligand stimulated fibroblast activation, as evidenced by mobilization of nuclear factor-kappaB and by induction of the proinflammatory and chemoattractant cytokines IL-6 and IL-8. IFN-gamma-primed lung fibroblasts costimulate T lymphocyte proliferation utilizing CD40, but not the well-studied costimulatory molecules B7-1 and B7-2.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor-kappaB	factor-kappab	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	chemoattractant	chemoattractant	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	6	6	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_
36	IFN-gamma	IFN-gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
40	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
41	costimulate	costimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	T	t	NUM	CD	NumType=Card	_	_	_	_
43	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
44	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
45	utilizing	utilize	VERB	VBG	VerbForm=Ger	_	_	_	_
46	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	not	not	ADV	RB	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
55	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
56	B	benefit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
57	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	B7	B7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3633
# text = Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	herein	herein	ADV	RB	_	_	_	_	_
4	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	cognate	cognate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CD40/CD40L	Cd40/cd40l	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
24	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
28	fibrogenesis	fibrogenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3634
# text = Document 003001249 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001249	003001249	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3635
# text = A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	DPA	DPA	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	member	member	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	subfamily	subfamily	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
21	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
27	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3636
# text = A novel DNA sequence element termed the J element involved in the regulated expression of class II major histocompatibility complex genes was recently described.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	termed	term	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	J	j	PROPN	NNP	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	class	class	NOUN	NN	Number=Sing	_	_	_	_
17	II	ii	NUM	CD	NumType=Card	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	recently	recently	ADV	RB	_	_	_	_	_
24	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3637
# text = To study this element and its role in class II gene regulation further, a cDNA library was screened with oligonucleotide probes containing both the S element and the nearby J element of the human DPA gene.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
7	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	further	further	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
18	library	library	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	screened	screen	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
23	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	S	s	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nearby	nearby	ADJ	JJ	Degree=Pos	_	_	_	_
32	J	j	NOUN	NN	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	DPA	DPA	PROPN	NNP	Number=Sing	_	_	_	_
38	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3638
# text = Several DNA clones were obtained by this procedure, one of which, clone 18, is reported and characterized here.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	one	one	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
15	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3639
# text = It encodes a protein predicted to contain 688 amino acid residues, including 11 zinc finger motifs of the C2H2 type in the C-terminal region, that are Kruppel-like in the conservation of the H/C link sequence connecting them.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
8	688	688	NUM	CD	NumType=Card	_	_	_	_
9	amino	amino	DET	DT	_	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
16	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	C2H2	C2h2	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	like	like	ADP	IN	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	H/	h/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	C	c	NOUN	NN	Number=Sing	_	_	_	_
40	link	link	NOUN	NN	Number=Sing	_	_	_	_
41	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
42	connecting	connect	VERB	VBG	VerbForm=Ger	_	_	_	_
43	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3640
# text = The 160 N-terminal amino acids in the nonfinger region of clone 18 are highly homologous with similar regions of several other human, mouse, and Drosophila sequences, defining a subfamily of Kruppel-like zinc finger proteins termed TAB (tramtrack [ttk]-associated box) here.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	160	160	NUM	CD	NumType=Card	_	_	_	_
3	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	amino	amino	DET	DT	_	_	_	_	_
6	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nonfinger	nonfinger	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
13	18	18	NUM	CD	NumType=Card	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	human	human	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	subfamily	subfamily	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
38	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
39	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
41	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	TAB	Tab	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	tramtrack	tramtrack	NOUN	NN	Number=Sing	_	_	_	_
45	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	ttk	ttk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3641
# text = One of the Drosophila sequences, ttk, is a developmental control gene, while a second does not contain a zinc finger region but encodes a structure important in oocyte development.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ttk	ttk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
23	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
29	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	oocyte	oocyte	ADJ	JJ	Degree=Pos	_	_	_	_
32	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3642
# text = An acidic activation domain is located between the N-terminal conserved region of clone 18 and its zinc fingers.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
15	18	18	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
19	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3643
# text = This protein appears to require both the S and J elements, which are separated by 10 bp for optimal binding.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	S	s	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	J	j	NOUN	NN	Number=Sing	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
21	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3644
# text = Antisense cDNA to clone 18 inhibited the expression of a reporter construct containing the DPA promoter, indicating its functional importance in the expression of this class II gene.
1	Antisense	Antisense	ADJ	JJ	Degree=Pos	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	clone	clone	VERB	VB	VerbForm=Inf	_	_	_	_
5	18	18	NUM	CD	NumType=Card	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DPA	DPA	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	class	class	NOUN	NN	Number=Sing	_	_	_	_
28	II	ii	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3645
# text = Document 003001250 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001250	003001250	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3646
# text = Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	amyloid	amyloid	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
19	microglia	microglia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3647
# text = An increasing body of evidence suggests that amyloid-beta (A beta) peptides and microglia are crucially involved in the pathogenesis of Alzheimer's disease.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
3	body	body	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	amyloid	amyloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	microglia	microglion	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	crucially	crucially	ADV	RB	_	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Alzheimer	Alzheimer	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	's	's	PART	POS	_	_	_	_	_
27	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3648
# text = In an effort to further elucidate the biological effects of A beta towards microglia, we investigated the ability of A beta peptides to activate nuclear factor (NF)-kappa B in the N9 murine microglial cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	effort	effort	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	further	further	ADV	RB	_	_	_	_	_
6	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	towards	towards	ADP	IN	_	_	_	_	_
14	microglia	microglion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	peptides	peptide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	N9	N9	PROPN	NNP	Number=Sing	_	_	_	_
37	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
38	microglial	microglial	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3649
# text = Co-stimulation of microglia with suboptimal concentrations of A beta(25-35) and 100 U/ml IFN gamma resulted in the detection of a specific NF-kappa B DNA-binding activity in nuclear extracts, as determined in gel mobility shift assays.
1	Co-stimulation	Co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	microglia	microglia	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	suboptimal	suboptimal	ADJ	JJ	Degree=Pos	_	_	_	_
6	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-35	-35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	100	100	NUM	CD	NumType=Card	_	_	_	_
16	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
18	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
19	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
20	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	as	as	SCONJ	IN	_	_	_	_	_
40	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
43	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
44	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
45	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3650
# text = This response required at least 120 min to be evident and supershift experiments revealed that the NF-kappa B complex contains both RelA and p50.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADV	RB	_	_	_	_	_
5	least	least	ADV	RBS	Degree=Sup	_	_	_	_
6	120	120	NUM	CD	NumType=Card	_	_	_	_
7	min	min	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
13	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
14	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	contains	contain	NOUN	NNS	Number=Plur	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3651
# text = Accordingly, immunoblot experiments showed that amongst NF-kappa B/Rel proteins, RelA and p50 are mobilized to the nucleus following microglial cell stimulation with A beta(25-35) plus IFN gamma.
1	Accordingly	accordingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	amongst	amongst	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	RelA	Rela	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mobilized	mobilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
24	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
25	microglial	microglial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	plus	plus	CCONJ	CC	_	_	_	_	_
37	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
38	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3652
# text = Higher concentrations of A beta(25-35) were effective by themselves in inducing NF-kappa B activation, both in the N9 microglial cell line and in rat primary microglia, as well as in human monocytes.
1	Higher	Higher	DET	DT	_	_	_	_	_
2	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	themselves	themselves	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	N9	N9	PROPN	NNP	Number=Sing	_	_	_	_
27	microglial	microglial	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
33	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
34	microglia	microglia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	as	as	ADV	RB	_	_	_	_	_
37	well	well	ADV	RB	Degree=Pos	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3653
# text = For purposes of comparison, microglia were also stimulated with bacterial LPS, a known NF-kappa B inducer.
1	For	for	ADP	IN	_	_	_	_	_
2	purposes	purpose	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	microglia	microglia	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3654
# text = As expected, LPS strongly induced the formation of two NF-kappa B DNA-binding activities, one of which was identified as RelA/p50.
1	As	as	ADP	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	strongly	strongly	ADV	RB	_	_	_	_	_
6	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3655
# text = The LPS response was also more rapid, as it was already evident by 40 min and remained sustained for up to 3 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	more	more	ADV	RBR	_	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	already	already	ADV	RB	_	_	_	_	_
13	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	40	40	NUM	CD	NumType=Card	_	_	_	_
16	min	min	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	up	up	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3656
# text = Collectively, these findings indicate that NF-kappa B activation might constitute one of the mechanisms underlying the inducible expression of kappa B-dependent genes in microglia stimulated by A beta peptides and IFN gamma, or by LPS.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	microglia	microglion	NOUN	NNS	Number=Plur	_	_	_	_
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
37	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3657
# text = Document 003001251 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001251	003001251	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3658
# text = Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells.
1	Potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	alkaloid	alkaloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	chronically	chronically	ADV	RB	_	_	_	_	_
17	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3659
# text = Cepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata and has been shown to have antiinflammatory, antiallergic, and immunomodulatory activities in vivo.
1	Cepharanthine	Cepharanthine	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	biscoclaurine	biscoclaurine	NOUN	NN	Number=Sing	_	_	_	_
5	alkaloid	alkaloid	NOUN	NN	Number=Sing	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	Stephania	Stephania	PROPN	NNP	Number=Sing	_	_	_	_
9	cepharantha	cepharantha	PROPN	NNP	Number=Sing	_	_	_	_
10	Hayata	Hayata	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
17	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	antiallergic	antiallergic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3660
# text = As several inflammatory cytokines and oxidative stresses are involved in the pathogenesis of HIV-1 infection, we investigated the inhibitory effects of cepharanthine on tumor necrosis factor alpha (TNF-alpha)- and phorbol 12-myristate 13-acetate (PMA)-induced HIV-1 replication in chronically infected cell lines.
1	As	as	ADP	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	stresses	stress	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
28	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	-	-	PUNCT	:	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
42	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	chronically	chronically	ADV	RB	_	_	_	_	_
56	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
58	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3661
# text = Two chronically HIV-1-infected cell lines, U1 (monocytic) and ACH-2 (T lymphocytic), were stimulated with TNF-alpha or PMA and cultured in the presence of various concentrations of the compound.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	chronically	chronically	NOUN	NN	Number=Sing	_	_	_	_
3	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	T	t	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytic	lymphocytic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
39	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	compound	compound	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3662
# text = HIV-1 replication was determined by p24 antigen level.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	p24	p24	NUM	CD	NumType=Card	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3663
# text = The inhibitory effects of cepharanthine on HIV-1 long terminal repeat (LTR)-driven gene expression and nuclear factor kappaB (NF-kappaB) activation were also examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	also	also	ADV	RB	_	_	_	_	_
32	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3664
# text = Cepharanthine dose dependently inhibited HIV-1 replication in TNF-alpha- and PMA-stimulated U1 cells but not in ACH-2 cells.
1	Cepharanthine	Cepharanthine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	dose	dose	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
3	dependently	dependently	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	U1	u1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	ACH	ACH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3665
# text = Its 50% effective and cytotoxic concentrations were 0.016 and 2.2 microg/ml in PMA-stimulated U1 cells, respectively.
1	Its	it	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	%	%	SYM	NN	Number=Sing	_	_	_	_
4	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	0.016	0.016	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	2.2	2.2	NUM	CD	NumType=Card	_	_	_	_
12	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	U1	u1	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3666
# text = Cepharanthine was found to suppress HIV-1 LTR-driven gene expression through the inhibition of NF-kappaB activation.
1	Cepharanthine	Cepharanthine	PRON	PRP	_	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
6	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3667
# text = These results indicate that cepharanthine is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	cepharanthine	cepharanthine	PRON	PRP	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	highly	highly	ADV	RB	_	_	_	_	_
9	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3668
# text = Since biscoclaurine alkaloids, containing cepharanthine as a major component, are widely used for the treatment of patients with various inflammatory diseases in Japan, cepharanthine should be further pursued for its chemotherapeutic potential in HIV-1-infected patients.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	biscoclaurine	biscoclaurine	NOUN	NN	Number=Sing	_	_	_	_
3	alkaloids	alkaloid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	widely	widely	ADV	RB	_	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Japan	Japan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	cepharanthine	cepharanthine	PRON	PRP	_	_	_	_	_
28	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	further	further	ADV	RB	_	_	_	_	_
31	pursued	pursue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	chemotherapeutic	chemotherapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3669
# text = Document 003001252 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001252	003001252	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3670
# text = Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	b	b	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
9	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
17	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3671
# text = Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation.
1	Self	self	NOUN	NN	Number=Sing	_	_	_	_
2	renewal	renewal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
6	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ErbB	ErbB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	Kit	Kit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3672
# text = To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family.
1	To	to	PART	TO	_	_	_	_	_
2	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3673
# text = Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts.
1	Ligand	Ligand	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	b	b	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3674
# text = In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	ligand	ligand	NUM	CD	NumType=Card	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Kit	Kit	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
14	any	any	DET	DT	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3675
# text = Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3676
# text = These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
4	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	perfectly	perfectly	ADV	RB	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
15	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	self	self	NOUN	NN	Number=Sing	_	_	_	_
17	renewal	renewal	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3677
# text = Document 003001253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001253	003001253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3678
# text = Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721]
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
5	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	40	40	NUM	CD	NumType=Card	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	J	j	PROPN	NNP	Number=Sing	_	_	_	_
28	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
29	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
30	1995	1995	NUM	CD	NumType=Card	_	_	_	_
31	Nov	Nov	PROPN	NNP	Number=Sing	_	_	_	_
32	3;270	3;270	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	44)	44)	SYM	NFP	_	_	_	_	SpaceAfter=No
35	:26721	:26721	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3679
# text = A DNA response element (TR2RE-SV40) for the TR2 orphan receptor, a member of the steroid-thyroid hormone receptor superfamily, has been identified in the simian virus 40 (SV40) +55 region (nucleotide numbers 368-389, 5'-GTTAAGGTTCGTAGGTCATGGA-3').
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
13	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	member	member	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
23	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
33	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
34	40	40	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	SV40	SV40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	+55	+55	NUM	CD	NumType=Card	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
42	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
43	368-389	368-389	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
47	-GTTAAGGTTCGTAGGTCATGGA	-GTTAAGGTTCGTAGGTCATGGa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3680
# text = Electrophoretic mobility shift assay, using in vitro translated TR2 orphan receptor with a molecular mass of 67 kilodaltons, showed a specific binding with high affinity (dissociation constant = 9 nM) for this DNA sequence.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
9	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TR2	TR2	NUM	CD	NumType=Card	_	_	_	_
11	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	67	67	NUM	CD	NumType=Card	_	_	_	_
19	kilodaltons	kilodalton	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
30	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
31	=	=	SYM	SYM	_	_	_	_	_
32	9	9	NUM	CD	NumType=Card	_	_	_	_
33	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
38	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3681
# text = DNA-swap experiments using chloramphenicol acetyl-transferase assay demonstrated that androgen can suppress the transcriptional activities of SV40 early promoter via the interaction between this TR2RE-SV40 and the chimeric receptor AR/TR2/AR with the DNA-binding domain of the TR2 orphan receptor flanked by the N-terminal and androgen-binding domains of the androgen receptor.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	swap	swap	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
6	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
9	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
10	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
20	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
25	between	between	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	AR/TR2/	AR/TR2/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AR	be	NOUN	NN	Number=Sing	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
45	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
47	flanked	flank	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-binding	-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
55	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
59	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3682
# text = In addition, this TR2RE-SV40 can function as a repressor to suppress the transcriptional activities of both SV40 early and late promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3683
# text = Together, these data suggest the TR2RE-SV40 may represent the first identified natural DNA response element for the TR2 orphan receptor that may function as a repressor for the SV40 gene expression.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	first	first	ADV	RBS	_	_	_	_	_
14	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
15	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
22	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3684
# text = Document 003001254 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001254	003001254	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3685
# text = T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells.
1	T	t	NOUN	NN	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
4	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3686
# text = The repetitive activation of T cells (priming) enhances the expression of many cytokines, such as IL-4, but not others, such as IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	repetitive	repetitive	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	priming	priming	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3687
# text = Molecular mechanisms underlying selective expression of cytokines by T cells remain poorly understood.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
4	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
13	understood	understand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3688
# text = Here we show that priming of CD4 T cells selectively enhances IL-4 expression relative to IL-2 expression by a transcriptional mechanism involving nuclear factor of activated T cells (NFAT) proteins.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	relative	relative	ADV	RB	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
26	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3689
# text = As detected by in vivo footprinting, priming markedly increases the activation-dependent engagement of the P0 and P1 NFAT-binding elements of the IL-4 promoter.
1	As	as	SCONJ	IN	_	_	_	_	_
2	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	P0	P0	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	P1	P1	PROPN	NNP	Number=Sing	_	_	_	_
21	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3690
# text = Moreover, each proximal P element is essential for optimal IL-4 promoter activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	each	each	DET	DT	_	_	_	_	_
4	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	P	p	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3691
# text = Activated primed CD4 T cells contain more NFAT1 and support greater NFAT-directed transcription than unprimed CD4 T cells, while activator protein 1 binding and activator protein 1-mediated transcription by both cell types is similar.
1	Activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
8	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
12	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	types	type	NOUN	NNS	Number=Plur	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3692
# text = Increased expression of wild-type NFAT1 substantially increases IL-4 promoter activity in unprimed CD4 T cells, suggesting NFAT1 may be limiting for IL-4 gene expression in this cell type.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	NFAT1	nfat1	PROPN	NNP	Number=Sing	_	_	_	_
8	substantially	substantially	ADV	RB	_	_	_	_	_
9	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggesting	VERB	VBG	VerbForm=Ger	_	_	_	_
22	NFAT1	nfat1	PROPN	NNP	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	limiting	limit	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3693
# text = Furthermore, a truncated form of NFAT1 acts as a dominant-negative, reducing IL-4 promoter activity in primed CD4 T cells and confirming the importance of endogenous NFAT to increased IL-4 gene expression by effector T cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	form	form	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
8	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	negative	negative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
32	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	4	4	NUM	CD	NumType=Card	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3694
# text = NFAT1 appears to be the major NFAT family member responsible for the initial increased expression of IL-4 by primed CD4 T cells.
1	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	member	member	NOUN	NN	Number=Sing	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3695
# text = Document 003001255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001255	003001255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3696
# text = Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
1	Host	host	ADJ	JJ	Degree=Pos	_	_	_	_
2	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3697
# text = The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
10	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-12	-12	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	innate	innate	ADJ	JJ	Degree=Pos	_	_	_	_
30	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
31	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3698
# text = Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	12	12	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
23	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	so	so	ADV	RB	_	_	_	_	_
25	remain	remain	VERB	VB	VerbForm=Inf	_	_	_	_
26	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3699
# text = Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimulators	stimulator	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	like	like	ADP	IN	_	_	_	_	_
29	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	TLRs	TLRs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3700
# text = Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TLR	Tlr	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
11	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
12	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
22	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
23	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3701
# text = Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TLRs	TLR	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
6	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
9	innate	innate	ADJ	JJ	Degree=Pos	_	_	_	_
10	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	against	against	ADP	IN	_	_	_	_	_
13	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3702
# text = Document 003001256 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001256	003001256	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3703
# text = Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3704
# text = IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3705
# text = Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines, IL-1 beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha by blocking gene transcription.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
43	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	alpha	alpha	ADV	RB	_	_	_	_	_
50	by	by	SCONJ	IN	_	_	_	_	_
51	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
52	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
53	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3706
# text = Using electrophoretic mobility shift assays (EMSA), we now show that, in monocytes stimulated with LPS or TNF alpha, IL-10 inhibits nuclear stimulation of nuclear factor kappa B (NF kappa
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	now	now	ADV	RB	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3707
# text = B), a transcription factor involved in the expression of inflammatory cytokine genes.
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3708
# text = Several other transcription factors including NF-IL-6, AP-1, AP-2, GR, CREB, Oct-1, and Sp-1 are not affected by IL-10.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Sp	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-1	-1	NUM	CD	NumType=Card	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3709
# text = This selective inhibition by IL-10 of NF kappa B activation occurs rapidly and in a dose-dependent manner and correlates well with IL-10's cytokine synthesis inhibitory activity in terms of both kinetics and dose responsiveness.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	well	well	ADV	RB	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	10's	10'	NOUN	NNS	Number=Plur	_	_	_	_
29	cytokine	cytokine	PRON	PRP	_	_	_	_	_
30	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	both	both	DET	DT	_	_	_	_	_
37	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	dose	dose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
40	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3710
# text = Furthermore, compounds such as tosylphenylalanyl chloromethyl ketone and pyrrolidinedithiocarbamate that are known to selectively inhibit NF kappa B activation block cytokine gene transcription in LPS-stimulated monocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	tosylphenylalanyl	tosylphenylalanyl	ADJ	JJ	Degree=Pos	_	_	_	_
7	chloromethyl	chloromethyl	NOUN	NN	Number=Sing	_	_	_	_
8	ketone	ketone	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	selectively	selectively	ADV	RB	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	block	block	NOUN	NN	Number=Sing	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3711
# text = Taken together, these results suggest that inhibition of NF kappa B activation may be an important mechanism for IL-10 suppression of cytokine gene transcription in human monocytes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3712
# text = IL-4, another cytokine that inhibits cytokine mRNA accumulation in monocytes, shows little inhibitory effect on LPS-induced NF kappa B activation.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	another	another	DET	DT	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cytokine	cytokine	PRON	PRP	_	_	_	_	_
10	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
17	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3713
# text = Further examination reveals that, unlike IL-10, IL-4 enhances mRNA degradation and does not suppress cytokine gene transcription.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	examination	examination	NOUN	NN	Number=Sing	_	_	_	_
3	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	unlike	unlike	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
15	mRNA	mRNa	SYM	SYM	_	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
21	cytokine	cytokine	PRON	PRP	_	_	_	_	_
22	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3714
# text = These data indicate that IL-10 and IL-4 inhibit cytokine production by different mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3715
# text = Document 003001257 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001257	003001257	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3716
# text = Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
13	necrosis	necrosis	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3717
# text = The first product of ascorbate oxidation, the ascorbate free radical (AFR), acts in biological systems mainly as an oxidant, and through its role in the plasma membrane redox system exerts different effects on the cell.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	product	product	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	ascorbate	ascorbate	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
10	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
11	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	AFR	AFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
19	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
20	mainly	mainly	ADV	RB	_	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	oxidant	oxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
32	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
33	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
34	system	system	NOUN	NN	Number=Sing	_	_	_	_
35	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
36	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
37	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3718
# text = We have investigated the role of ascorbate, AFR and dehydroascorbate (DHA) in the activation of the NF-kappaB transcription factor in Jurkat T-cells stimulated by tumour necrosis factor-alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	AFR	Afr	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	dehydroascorbate	dehydroascorbate	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	DHA	DHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
27	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3719
# text = Here we show, by electrophoretic mobility shift assays, that ascorbate increases the binding of NF-kappaB to DNA in TNF-alpha-stimulated Jurkat cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
7	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
8	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
9	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
13	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3720
# text = The ability of ascorbate to enhance cytoplasmic inhibitory IkBalpha protein degradation correlates completely with its capacity to induce NF-kappaB binding to DNA and to potentiate NF-kappaB-mediated transactivation of the HIV-1 long terminal repeat promoter in TNF-alpha-stimulated Jurkat cells but not in cells stimulated with PMA plus ionomycin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
7	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
9	IkBalpha	IkBalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
40	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
41	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	but	but	CCONJ	CC	_	_	_	_	_
52	not	not	PART	RB	_	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
55	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	with	with	ADP	IN	_	_	_	_	_
57	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
58	plus	plus	CCONJ	CC	_	_	_	_	_
59	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3721
# text = AFR behaves like ascorbate, while DHA and ascorbate phosphate do not affect TNF-alpha-mediated NF-kappaB activation.
1	AFR	Afr	ADJ	JJR	Degree=Cmp	_	_	_	_
2	behaves	behave	NOUN	NNS	Number=Plur	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	DHA	DHA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ascorbate	ascorbate	ADJ	JJ	Degree=Pos	_	_	_	_
10	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3722
# text = These results provide new evidence for a possible relationship between the activation of the electron-transport system at the plasma membrane by ascorbate or its free radical and redox-dependent gene transcription in T-cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
9	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	electron	electron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	transport	transport	NOUN	NN	Number=Sing	_	_	_	_
18	system	system	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
22	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
28	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	redox	redox	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3723
# text = Document 003001258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001258	003001258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3724
# text = Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	rapidly	rapidly	ADV	RB	_	_	_	_	_
9	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-kappa	-kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3725
# text = B.
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3726
# text = The B cell-associated surface molecule CD40 functions to regulate B cell responses.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B	B	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3727
# text = Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production, and, in combination with cytokines, to Ig isotype switching.
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	homotypic	homotypic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	Ig	ig	VERB	VB	VerbForm=Inf	_	_	_	_
29	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
30	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3728
# text = Tyrosine kinase activity is increased shortly after engagement of this receptor.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	shortly	shortly	ADV	RB	_	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3729
# text = Little is known about how the very early events induced by CD40 cross-linking link to cellular responses.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	about	about	SCONJ	IN	_	_	_	_	_
5	how	how	ADV	WRB	PronType=Int	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
13	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
15	link	link	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3730
# text = In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	after	after	SCONJ	IN	_	_	_	_	_
28	cross-linking	cross-link	VERB	VBG	VerbForm=Ger	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
30	on	on	SCONJ	IN	_	_	_	_	_
31	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	tonsillar	tonsillar	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3731
# text = The activation is rapid and is mediated through a tyrosine kinase-dependent pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3732
# text = The complexes detected in electrophoretic mobility shift assays contain p50, p65 (RelA), c-Rel, and most likely other components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
6	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
9	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	p65	p65	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3733
# text = By using transient transfection assays, we found that cross-linking CD40 supports NF-kappa B-dependent gene expression.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
4	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
12	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
13	supports	support	NOUN	NNS	Number=Plur	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3734
# text = Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	event	event	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
16	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3735
# text = Document 003001259 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001259	003001259	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3736
# text = A negative regulatory region containing a glucocorticosteroid response element (nGRE) in the human interleukin-1beta gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	glucocorticosteroid	glucocorticosteroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	nGRE	nGRE	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	gene.	gene.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 3737
# text = Interleukin-1 beta (IL-1beta) is one of the most important inflammatory mediators in human inflammatory and immunological diseases.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	most	most	ADV	RBS	_	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
24	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3738
# text = The regulation of human IL-1beta gene expression has been studied for several years, and a few regulatory elements have been discovered in the promoter region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3739
# text = However, little is known about negative regulation of IL-1beta expression at the transcriptional level, which may play an important role in anti-inflammatory and immunosuppressive effects.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	about	about	ADP	IN	_	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
30	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3740
# text = We have identified a negative regulatory element located in the region between -685 and -395.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	-685	-685	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	395	395	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3741
# text = Within this region, a 19-bp nuclear factor binding site (-570 to -552) was characterized by DNase I footprinting and electromobility shift assay.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	(-570	(-570	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	552	552	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	electromobility	electromobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3742
# text = A consensus sequence for a negative glucocorticoid response element (nGRE) and a transcription activator protein-2 binding site were noted within this footprint.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	nGRE	nGRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	within	within	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3743
# text = Functional studies showed a 2.5-fold increase in promoter activity when this 19-bp binding site was deleted in the reporter constructs IL-1beta/CAT and IL-1beta/SV40 promoter/CAT.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	constructs	construct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
40	CAT.	CAT.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3744
# text = Dexamethasone (10(-8) M) repressed chloramphenicol acetyltransferase (CAT) production by 75% in the wild-type fragment but not in a deletion mutant lacking the 19-bp site.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
5	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	M	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
30	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
31	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3745
# text = A protein of about 150 kD that bound to this negative regulatory sequence was identified by UV cross-linking.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	about	about	ADV	RB	_	_	_	_	_
5	150	150	NUM	CD	NumType=Card	_	_	_	_
6	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	ADV	WRB	PronType=Rel	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
18	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-linking	-linking	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3746
# text = This is the first description of a negative regulatory region responsive to glucocorticoids in a cytokine gene.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	description	description	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3747
# text = Document 003001260 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001260	003001260	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3748
# text = Differences in transcriptional enhancers of HIV-1 and HIV-2.
1	Differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3749
# text = Response to T cell activation signals.
1	Response	response	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3750
# text = T cell activation results in high levels of HIV replication and is thought to be one mechanism leading to the conversion from latent to active viral infection.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	conversion	conversion	NOUN	NN	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	latent	latent	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3751
# text = In HIV-1, the sequences that respond to these signaling events are found in the long terminal repeat (LTR) and comprise the transcriptional enhancer, which contains two conserved binding sites for the nuclear factor kappa B (NF kappa
1	In	in	ADP	IN	_	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	events	event	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
19	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
20	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	comprise	comprise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	two	two	NUM	CD	NumType=Card	_	_	_	_
33	conserved	conserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3752
# text = B).
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3753
# text = The corresponding region in the second AIDS retrovirus, HIV-2, contains a conserved and a divergent NF kappa B binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
8	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3754
# text = We demonstrate that the HIV-1 LTR responds better than the HIV-2 LTR to T cell activation signals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
9	responds	respond	NOUN	NNS	Number=Plur	_	_	_	_
10	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3755
# text = These qualitative differences in the response to T cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a heterologous promoter but also when these enhancers are switched between their respective LTR.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	qualitative	qualitative	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	reproduced	reproduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	placed	place	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	when	when	ADV	WRB	PronType=Int	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
36	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	switched	switch	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	between	between	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
41	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3756
# text = In electrophoretic mobility shift assays, NF kappa B binds to both conserved sites in the HIV-1 transcriptional enhancer and only to the single conserved site in the HIV-2 transcriptional enhancer.
1	In	in	ADP	IN	_	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	only	only	ADV	RB	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
27	conserved	conserve	ADJ	JJ	Degree=Pos	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3757
# text = Instead of NF kappa B, the activator protein 3 binds to the divergent site in HIV-2.
1	Instead	instead	ADV	RB	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3758
# text = In conclusion, HIV-1 and HIV-2 are differentially regulated by T cell activation signals, and this difference may account for the longer period of viral latency observed with HIV-2 than with HIV-1 infection.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	differentially	differentially	ADV	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	longer	longer	ADJ	JJ	Degree=Pos	_	_	_	_
28	period	period	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
32	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	than	than	ADP	IN	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3759
# text = Document 003001261 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001261	003001261	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3760
# text = Defining therapeutic targets by using adenovirus:
1	Defining	defining	VERB	VBG	VerbForm=Ger	_	_	_	_
2	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
3	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	SCONJ	IN	_	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3761
# text = blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
1	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	destructive	destructive	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	synovium	synovium	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	spares	spare	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3762
# text = The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	long	long	ADV	RB	Degree=Pos	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	subject	subject	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	controversy	controversy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3763
# text = We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
5	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	diseased	diseased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
32	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
36	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	%	%	SYM	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
41	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3764
# text = We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
24	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
25	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
32	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	like	like	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	10	10	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-11	-11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3765
# text = Of even more interest, IkappaBalpha overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor.
1	Of	of	ADP	IN	_	_	_	_	_
2	even	even	ADV	RB	_	_	_	_	_
3	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
4	interest	interest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	matrix	matrix	NUM	CD	NumType=Card	_	_	_	_
13	metalloproteinases	metalloproteinase	NOUN	NNS	Number=Plur	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	while	while	SCONJ	IN	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3766
# text = Blocking NF-kappaB in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction.
1	Blocking	Blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	joint	joint	NOUN	NN	Number=Sing	_	_	_	_
9	thus	thus	ADV	RB	_	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	very	very	ADV	RB	_	_	_	_	_
13	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
14	profile	profile	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
24	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3767
# text = The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
3	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	here	here	ADV	RB	PronType=Dem	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
8	applicability	applicability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
11	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
12	testing	testing	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
20	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
21	target	target	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	either	either	DET	DT	_	_	_	_	_
24	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	diseased	disease	ADJ	JJ	Degree=Pos	_	_	_	_
32	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
33	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3768
# text = Document 003001262 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001262	003001262	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3769
# text = The control of lytic replication of Epstein-Barr virus in B lymphocytes (Review).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Review	Review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3770
# text = Uncontrolled replication of a virus, which is harmful to the host is also disadvantageous to the virus.
1	Uncontrolled	Uncontroll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	harmful	harmful	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	host	host	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	disadvantageous	disadvantageous	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3771
# text = Most viruses cannot compete with the various immune mechanisms and become eliminated in the course of infection.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
4	not	not	PART	RB	_	_	_	_	_
5	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
13	eliminated	eliminated	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	course	course	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3772
# text = Therefore, only the time between infection and eradication remains for these viruses to proliferate.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	time	time	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	eradication	eradication	NOUN	NN	Number=Sing	_	_	_	_
10	remains	remain	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3773
# text = A few viruses, like the Herpesviruses or the papillomaviruses, however, have developed a sophisticated strategy for persisting lifelong, usually asymptomatically in the host, hiding from the immune system and producing infectious progeny at the same time.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
3	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	like	like	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Herpesviruses	Herpesviruse	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	papillomaviruses	papillomaviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	sophisticated	sophisticate	ADJ	JJ	Degree=Pos	_	_	_	_
18	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	persisting	persist	VERB	VBG	VerbForm=Ger	_	_	_	_
21	lifelong	lifelong	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	usually	usually	ADV	RB	_	_	_	_	_
24	asymptomatically	asymptomatically	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	hiding	hide	VERB	VBG	VerbForm=Ger	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
33	system	system	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
36	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
37	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
38	at	at	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
41	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3774
# text = This strategy depends on a separation of latency and the lytic replication, either by time due to differentiation-dependent mechanisms or by spatial separation as the result of different host cell types.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
3	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	spatial	spatial	ADJ	JJ	Degree=Pos	_	_	_	_
26	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	result	result	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
32	host	host	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3775
# text = Both are true for the Epstein-Barr virus (EBV).
1	Both	both	DET	DT	_	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3776
# text = B cells and epithelial cells have a pivotal role in the life cycle of the virus.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	life	life	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3777
# text = The former can become latently infected and are thought to be the virus reservoir in vivo, whereas the latter were shown to be permissive for lytic replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	former	former	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
5	latently	latently	ADV	RB	_	_	_	_	_
6	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3778
# text = However, replication of EBV in vivo is controlled primarily by host immune mechanisms selecting for cells that are not permissive for viral replication as the result of a particular set of transcription factors.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	primarily	primarily	ADV	RB	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	host	host	NOUN	NN	Number=Sing	_	_	_	_
13	immune	immune	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	selecting	selecte	VERB	VBG	VerbForm=Ger	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	result	result	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
31	set	set	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3779
# text = These factors control the activity of the regulatory immediate-early genes and, in addition, lytic and latent cycle regulatory genes negatively interfere with each other and thus link cellular and viral gene regulatory mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	negatively	negatively	ADV	RB	_	_	_	_	_
25	interfere	interfere	ADV	RB	PronType=Dem	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	thus	thus	ADV	RB	_	_	_	_	_
31	link	link	NOUN	NN	Number=Sing	_	_	_	_
32	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3780
# text = Disturbance of both the immune surveillance as well as viral gene regulation may result in EBV-associated disease.
1	Disturbance	Disturbance	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
6	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3781
# text = Document 003001263 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001263	003001263	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3782
# text = Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
28	PEBP2/	PEBP2/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
29	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3783
# text = The receptor for the macrophage colony-stimulating factor (or colony-stimulating factor 1 [CSF-1]) is expressed from different promoters in monocytic cells and placental trophoblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	or	or	CCONJ	CC	_	_	_	_	_
12	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	placental	placental	ADJ	JJ	Degree=Pos	_	_	_	_
33	trophoblasts	trophoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3784
# text = We have demonstrated that the monocyte-specific expression of the CSF-1 receptor is regulated at the level of transcription by a tissue-specific promoter whose activity is stimulated by the monocyte/B-cell-specific transcription factor PU.1 (D.-E.Zhang, C.J.Hetherington, H.-M.Chen, and D.G.Tenen, Mol.Cell.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	monocyte/B-cell	monocyte/B-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	D.	D.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	E.Zhang	E.Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	C.J.Hetherington	C.J.Hetherington	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	H.-M.	H.-M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	Chen	Chen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	D.G.Tenen	D.G.Tenen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	Mol.Cell	Mol.Cell	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3785
# text = Biol.14:373-381, 1994).
1	Biol.14:373-381	Biol.14:373-381	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1994	1994	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3786
# text = Here we report that the tissue specificity of this promoter is also mediated by sequences in a region II (bp -88 to - 59), which lies 10 bp upstream from the PU.1-binding site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
7	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	88	88	NUM	CD	NumType=Card	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	_
26	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	10	10	NUM	CD	NumType=Card	_	_	_	_
32	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
33	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3787
# text = When analyzed by DNase footprinting, region II was protected preferentially in monocytic cells.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
5	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	PRON	PRP	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	preferentially	preferentially	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3788
# text = Electrophoretic mobility shift assays confirmed that region II interacts specifically with nuclear proteins from monocytic cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3789
# text = Two gel shift complexes (Mono A and Mono B) were formed with separate sequence elements within this region.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
7	A	A	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3790
# text = Competition and supershift experiments indicate that Mono B contains a member of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family, which includes the AML1 gene product, while Mono A is a distinct complex preferentially expressed in monocytic cells.
1	Competition	competition	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	core	core	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PEBP2/	PEBP2ith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	while	while	SCONJ	IN	_	_	_	_	_
39	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	no	no	DET	DT	_	_	_	_	_
41	A	a	NOUN	NN	Number=Sing	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
45	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
46	preferentially	preferentially	ADV	RB	_	_	_	_	_
47	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3791
# text = Promoter constructs with mutations in these sequence elements were no longer expressed specifically in monocytes.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	constructs	construct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	no	no	ADV	RB	_	_	_	_	_
11	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3792
# text = Furthermore, multimerized region II sequence elements enhanced the activity of a heterologous thymidine kinase promoter in monocytic cells but not other cell types tested.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	types	type	NOUN	NNS	Number=Plur	_	_	_	_
25	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3793
# text = These results indicate that the monocyte/B-cell-specific transcription factor PU.1 and the Mono A and Mono B protein complexes act in concert to regulate monocyte-specific transcription of the CSF-1 receptor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocyte/B-cell	monocyte/B-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
15	A	a	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
21	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3794
# text = Document 003001264 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001264	003001264	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3795
# text = Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
11	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3796
# text = T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor mRNA levels.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
3	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
11	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
24	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
42	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
48	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
52	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
53	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3797
# text = We report here that 1,25(OH)2D3-mediated repression in Jurkat cells is cycloheximide resistant, suggesting that it is a direct transcriptional repressive effect on IL-2 expression by the vitamin D3 receptor (VDR).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
37	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3798
# text = We therefore examined vitamin D3-mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
5	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	cotransfecting	cotransfect	VERB	VBG	VerbForm=Ger	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	VDR	VDR	ADJ	JJR	Degree=Cmp	_	_	_	_
30	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
31	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	by	by	SCONJ	IN	_	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3799
# text = We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3-mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element, NF-AT-1, which is bound by a T-cell-specific transcription factor, NFATp, as well as by AP-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	delineated	delineate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
28	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	as	as	ADV	RB	_	_	_	_	_
60	well	well	ADV	RB	Degree=Pos	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	by	by	ADP	IN	_	_	_	_	_
63	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3800
# text = VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression.
1	VDR	VDR	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	bind	bind	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	repress	repress	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
27	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	bound	bound	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3801
# text = These results indicate that DNA binding by VDR is necessary but not sufficient to mediate IL-2 repression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3802
# text = By combining partially purified proteins in vitro, we observed the loss of the bound NFATp/AP-1-DNA complex upon inclusion of VDR or VDR-retinoid X receptor.
1	By	by	SCONJ	IN	_	_	_	_	_
2	combining	combi	VERB	VBG	VerbForm=Ger	_	_	_	_
3	partially	partially	ADV	RB	_	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	inclusion	inclusion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	X	x	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3803
# text = Order of addition and off-rate experiments indicate that the VDR-retinoid X receptor heterodimer blocks NFATp/AP-1 complex formation and then stably associates with the NF-AT-1 element.
1	Order	order	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	off	off	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
15	X	x	ADP	IN	_	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
18	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
19	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	then	then	ADV	RB	PronType=Dem	_	_	_	_
28	stably	stably	ADV	RB	_	_	_	_	_
29	associates	associate	VERB	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	AT	at	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3804
# text = This direct inhibition by a nuclear hormone receptor of transcriptional activators of the IL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	mechanistic	mechanistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	how	how	ADV	WRB	PronType=Int	_	_	_	_
25	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
26	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
31	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
32	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3805
# text = Document 003001265 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001265	003001265	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3806
# text = Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
3	intermediates	intermediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	apparently	apparently	ADV	RB	_	_	_	_	_
6	widely	widely	ADV	RB	_	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3807
# text = Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes.
1	Hydrogen	Hydrogen	ADJ	JJ	Degree=Pos	_	_	_	_
2	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
5	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
8	commonly	commonly	ADV	RB	_	_	_	_	_
9	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3808
# text = In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3809
# text = The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	potently	potently	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
29	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3810
# text = N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2.
1	N-acetyl	N-acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-L-	-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	well	well	ADV	RB	Degree=Pos	_	_	_	_
10	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	counteracts	counteract	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
19	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ROI	Roi	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	living	living	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3811
# text = NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
5	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
24	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
31	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
32	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3812
# text = This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
5	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
6	thought	think	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	all	all	ADV	RB	_	_	_	_	_
19	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3813
# text = ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B.
1	ROI	ROI	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
7	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	indirectly	indirectly	ADV	RB	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	release	release	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3814
# text = Document 003001266 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001266	003001266	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3815
# text = Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection.
1	Processing	processing	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3816
# text = Transcription of the human immunodeficiency virus type-1 (HIV-1) genome is regulated in part by cellular factors and is stimulated by activation of latently infected T cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	part	part	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	latently	latently	ADV	RB	_	_	_	_	_
30	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3817
# text = T-cell activation also correlates with the induction of the factor NF-kappa B which binds to two adjacent sites in the HIV-1 long terminal repeat.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3818
# text = This factor consists of two DNA-binding subunits of relative molecular mass 50,000 (50K) associated with two 65K subunits.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
14	50,000	50,000	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	K	k	NUM	CD	NumType=Card	_	_	_	_
24	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3819
# text = It is located in the nucleus in mature B cells, but is present in other cell types as an inactive cytoplasmic complex.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3820
# text = External stimuli, including those that activate T cells, result in nuclear translocation of active NF-kappa B.
1	External	external	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
5	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	result	result	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3821
# text = The cloning of the complementary DNA for the 50K subunit helped to identify an exclusively cytoplasmic 105K precursor (p105) (V.B., P.K. and A.I., manuscript submitted).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	K	k	NUM	CD	NumType=Card	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	helped	help	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	exclusively	exclusively	ADV	RB	_	_	_	_	_
17	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
18	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	K	k	NUM	CD	NumType=Card	_	_	_	_
20	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	V.B.	V.B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	P.K.	P.K.	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	A.I.	A.I.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	manuscript	manuscript	NOUN	NN	Number=Sing	_	_	_	_
32	submitted	submit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3822
# text = The expression of active NF-kappa B might therefore also be regulated by the extent of processing of p105.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
10	therefore	therefore	ADV	RB	_	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3823
# text = Because HIV-1 requires active NF-kappa B for efficient transcription, we tested the effect of HIV-1 infection on the processing of the human 105K precursor.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	K	k	NUM	CD	NumType=Card	_	_	_	_
32	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3824
# text = We show here that the HIV-1 protease can process p105 and increases levels of active nuclear NF-kappa B complex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	process	process	VERB	VB	VerbForm=Inf	_	_	_	_
12	p105	p105	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3825
# text = Document 003001267 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001267	003001267	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3826
# text = Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
3	display	display	NOUN	NN	Number=Sing	_	_	_	_
4	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
11	D	d	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3827
# text = To characterize further the function of the intracellular vitamin D receptor (VDR), we have developed stable transfectant variants of a vitamin D-responsive cell line (U937) which express either decreased or increased numbers of VDR.
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D	d	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
20	transfectant	transfectant	ADJ	JJ	Degree=Pos	_	_	_	_
21	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
25	D-	D-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
34	either	either	CCONJ	CC	_	_	_	_	_
35	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3828
# text = In this study we have analyzed changes in gene expression associated with this variable VDR expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
15	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3829
# text = Initial experiments indicated that a 50% decrease in VDR levels was associated with a 2-fold increase in cell proliferation and a similar rise in c-myc mRNA expression.
1	Initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	VDR	Vdr	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3830
# text = Further studies were carried out using differential RNA display (DD).
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	out	out	ADP	RP	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
8	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
9	display	display	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	DD	D	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3831
# text = Sequence analysis of DD products revealed two cDNAs with identity to known gene products: the catalytic sub-unit of DNA-protein kinase (DNA-PK(CS)), and the peroxisomal enzyme 17beta-hydroxysteroid dehydrogenase type IV (17beta-HSD IV).
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DD	DD	PROPN	NNP	Number=Sing	_	_	_	_
5	products	product	NOUN	NNS	Number=Plur	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	sub-unit	sub-unit	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	PK	PK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CS	CS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	peroxisomal	peroxisomal	ADJ	JJ	Degree=Pos	_	_	_	_
36	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
37	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	hydroxysteroid	hydroxysteroid	NOUN	NN	Number=Sing	_	_	_	_
40	dehydrogenase	dehydrogenase	NOUN	NN	Number=Sing	_	_	_	_
41	type	type	NOUN	NN	Number=Sing	_	_	_	_
42	IV	iv	PROPN	NNP	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	17beta	17beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	HSD	Hsd	PROPN	NNP	Number=Sing	_	_	_	_
47	IV	iv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3832
# text = Northern analysis confirmed that expression of both mRNAs was reduced in cells with decreased numbers of VDR.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3833
# text = Down-regulation of 17beta-HSD IV mRNA expression was associated with enhanced estradiol inactivation by U937 cells, suggesting a link between estrogenic pathways and cell proliferation.
1	Down	down	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	HSD	Hsd	NOUN	NN	Number=Sing	_	_	_	_
8	IV	iv	NOUN	NN	Number=Sing	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	_
16	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	link	link	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	estrogenic	estrogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3834
# text = Further Northern analyses indicated that there was no significant change in 17beta-HSD IV or DNA-PK(CS) mRNA levels following treatment with 1,25(OH)2D3, although expression of both genes varied with changes in cell proliferation.
1	Further	further	ADV	RB	_	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	there	there	PRON	EX	_	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	change	change	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	HSD	Hsd	NOUN	NN	Number=Sing	_	_	_	_
15	IV	iv	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	PK	Pk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CS	CS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	although	although	SCONJ	IN	_	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	both	both	DET	DT	_	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	varied	varied	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3835
# text = These data suggest that, in addition to its established role as a hormone-dependent trans-activator, VDR may influence gene expression by ligand-independent mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
24	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
30	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3836
# text = Document 003001268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001268	003001268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3837
# text = Mapping of the transcriptional repression domain of the lymphoid-specific transcription factor oct-2A.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	oct	oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3838
# text = The lymphoid-specific transcription factor Oct-2a is implicated in B cell-specific transcriptional activity via the octamer motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	via	via	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
23	motif.	motif.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3839
# text = Structure/function analysis of various Oct-2a effector regions in the context of the GAL4 DNA-binding domain revealed that Oct-2a contains two functionally different activation domains at the N and the C termini.
1	Structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
12	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	context	context	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	contains	contain	NOUN	NN	Number=Sing	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	functionally	functionally	ADV	RB	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	N	N	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	C	C	NOUN	NN	Number=Sing	_	_	_	_
41	termini	termini	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3840
# text = The transcriptional activity of both domains is strongly potentiated by interactions with distinct B cell-specific coactivators.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	coactivators	coactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3841
# text = Recently, we have identified a repression domain located within the N terminus of Oct-2a (amino acids 2-99).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	N	N	PROPN	NNP	Number=Sing	_	_	_	_
13	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
20	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	99	99	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3842
# text = When this domain was transferred to a potent activator, transcription was strongly inhibited.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	transferred	transfer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3843
# text = In this study we present a deletion analysis of the N-terminal region of Oct-2a to determine the minimal repression domain.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2a	2a	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3844
# text = We identified a stretch of 23 amino acids, rich in serine and threonine residues, which was responsible for most of the repression activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	stretch	stretch	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	23	23	NUM	CD	NumType=Card	_	_	_	_
7	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
8	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3845
# text = We show that repression is strongly dependent on the type of enhancer present in the reporter plasmid as well as on the cell line tested.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	strongly	strongly	ADV	RB	_	_	_	_	_
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3846
# text = The possibility that Oct-2a can act as an activator and/or a repressor may have important consequences for the function of Oct-2a in B cell differentiation and other developmental processes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	a	a	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	or	or	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
36	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
37	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3847
# text = Document 003001269 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001269	003001269	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3848
# text = Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	type-	type-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
21	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	family	family	NOUN	NN	Number=Sing	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3849
# text = The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	potently	potently	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3850
# text = Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified.
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	299	299	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	228	228	NUM	CD	NumType=Card	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	CArG	Carg	NOUN	NN	Number=Sing	_	_	_	_
21	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3851
# text = We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	essential	essential	NOUN	NN	Number=Sing	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	137	137	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	64	64	NUM	CD	NumType=Card	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3852
# text = This element had maximal activity in lymphoid cells, paralleling the cell type specificity of Elf-1 expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	paralleling	parallel	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3853
# text = Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3854
# text = Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	137	137	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	64	64	NUM	CD	NumType=Card	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	7	7	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3855
# text = Elf-1 physically associated with HMG-I and with NF-kappa B p50 and c-Rel in vitro, suggesting that protein-protein interactions might functionally coordinate the actions of the upstream and downstream positive regulatory elements.
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	physically	physically	ADV	RB	_	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
29	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
30	functionally	functionally	ADV	RB	_	_	_	_	_
31	coordinate	coordinate	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
39	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
41	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3856
# text = This is the first report of a physical interaction between an Ets family member and NF-kappa B family proteins.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3857
# text = These findings provide significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression and also have implications for other genes regulated by Elf-1 and NF-kappa B family proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-type-specific	-type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	X	LS	_	_	_	_	SpaceAfter=No
25	R	r	X	GW	_	_	_	_	_
26	alpha	alpha	X	GW	_	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	family	family	NOUN	NN	Number=Sing	_	_	_	_
47	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3858
# text = Document 003001270 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001270	003001270	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3859
# text = LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha.
1	LMP	Lmp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
13	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha.	alpha.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 3860
# text = LMP-1, an Epstein-Barr virus membrane protein expressed during latent infection, has oncogenic properties, as judged from its ability to transform B lymphocytes and rodent fibroblasts.
1	LMP	Lmp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
19	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	judged	judged	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	transform	transform	VERB	VB	VerbForm=Inf	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
32	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3861
# text = LMP-1 induces the expression of bcl2, an oncogene which protects cells from apoptosis, as well as of genes encoding other proteins involved in cell regulation and growth control.
1	LMP	Lmp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	bcl2	bcl2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3862
# text = The mechanisms by which LMP-1 upregulates these proteins is unknown, but it is plausible that LMP-1 modifies signal transduction pathways that result in the activation of one or more transcription factors that ultimately regulate transcription of oncogenic genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	upregulates	upregulate	NOUN	NNS	Number=Plur	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	plausible	plausible	ADJ	JJ	Degree=Pos	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	modifies	modify	NOUN	NNS	Number=Plur	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
25	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	result	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	one	one	NUM	CD	NumType=Card	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	ultimately	ultimately	ADV	RB	_	_	_	_	_
39	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
43	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3863
# text = NF-kappa B, a transcription factor controlling the expression of genes involved in cell activation and growth control, has been shown to be activated by LMP-1.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3864
# text = The mechanism(s) regulating this activation remains unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3865
# text = Our data indicate that increased NF-kappa B DNA binding and functional activity are present in B-lymphoid cells stably or transiently expressing LMP-1.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	stably	stably	ADV	RB	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	transiently	transiently	ADV	RB	_	_	_	_	_
25	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
26	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3866
# text = I kappa B alpha is selectively modified in LMP-1-expressing B cells.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	selectively	selectively	ADV	RB	_	_	_	_	_
7	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3867
# text = A phosphorylated form of I kappa B alpha and increased protein turnover-degradation correlate with increased NF-kappa B nuclear translocation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
15	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3868
# text = This results in increased transcription of NF-kappa B-dependent-genes, including those encoding p105 and I kappa B alpha (MAD3).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
19	p105	p105	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	B	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3869
# text = These results indicate that LMP-1 activates NF-kappa B in B-cell lines by targeting I kappa B alpha.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	targeting	targete	VERB	VBG	VerbForm=Ger	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3870
# text = Identification of the pathways activated by LMP-1 to result in posttranslational modifications of I kappa B alpha will aid in determining the role of this virus-host cell protein interaction in Epstein-Barr virus-mediated oncogenesis.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
14	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
21	aid	aid	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	host	host	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
38	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	oncogenesis	oncogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3871
# text = Document 003001271 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001271	003001271	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3872
# text = Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-stimulating	-stimulat	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
10	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3873
# text = Granulocyte colony-stimulating factor (G-CSF) signaling involves activation of STATs, proteins that serve the dual function of signal transduction and activation of transcription.
1	Granulocyte	Granulocyte	PROPN	NNP	Number=Sing	_	_	_	_
2	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
11	involves	involve	NOUN	NNS	Number=Plur	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3874
# text = We previously demonstrated that G-CSF activated a distinct Stat3-like protein in immature and mature normal myeloid cells, StatG.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	G-	G-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	StatG	StatG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3875
# text = StatG in normal immature human myeloid cells, i.e. adult CD34+ bone marrow cells, was composed of Stat3beta.
1	StatG	Statg	PRON	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	i.e.	i.e.	X	FW	_	_	_	_	_
10	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD34	CD34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
14	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3876
# text = This investigation was undertaken to determine the composition of StatG in mature normal human myeloid cells, i.e. polymorphonuclear neutrophilic granulocytes (PMN).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	StatG	Statg	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	i.e.	i.e.	X	FW	_	_	_	_	_
19	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	neutrophilic	neutrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	PMN	Pmn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3877
# text = These studies revealed that the major protein in extracts of PMN activated by G-CSF to bind the high-affinity serum-inducible element (hSIE) is a 72-kDa protein that cross-reacts with Stat3 monoclonal antibody, which we have designated Stat3gamma.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PMN	PMN	PROPN	NNP	Number=Sing	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	element	element	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	hSIE	hsie	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	cross-reacts	cross-react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
39	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
40	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
44	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3878
# text = Stat3gamma is derived from Stat3alpha by limited proteolysis and lacks the carboxyl-terminal portion of Stat3alpha.
1	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
17	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3879
# text = Because this region of Stat3alpha is involved in transcriptional activation, our findings suggest the possibility that Stat3gamma may be transcriptionally inactive and may compete with Stat3alpha for Stat3 binding sites in these terminally differentiated myeloid cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
14	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
15	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
24	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	terminally	terminally	ADV	RB	_	_	_	_	_
38	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3880
# text = Document 003001272 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001272	003001272	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3881
# text = NF-kappa B-independent suppression of HIV expression by ascorbic acid.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	ascorbic	ascorbic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3882
# text = Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha).
1	Ascorbic	Ascorbic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	latently	latently	ADV	RB	_	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3883
# text = To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF-kappa B, we carried out gel shift analysis on nuclear extracts prepared under different conditions of cell stimulation in the presence or absence of ascorbate, N-acetylcysteine (NAC), or zidovudine (AZT).
1	To	to	PART	TO	_	_	_	_	_
2	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	out	out	ADP	RP	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
30	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	under	under	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	or	or	CCONJ	CC	_	_	_	_	_
52	zidovudine	zidovudine	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	AZT	AZT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3884
# text = Pretreatment of ACH-2 T cells by NAC followed by stimulation with PMA, TNF-alpha, or hydrogen peroxide (H2O2) resulted in strong suppression of NF-kappa B activation.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ACH	ACH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
10	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	hydrogen	hydrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
30	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3885
# text = In contrast, neither ascorbate nor AZT affected NF-kappa B activity under all three induction conditions in the ACH-2 cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	neither	neither	CCONJ	CC	_	_	_	_	_
5	ascorbate	ascorbate	ADJ	JJ	Degree=Pos	_	_	_	_
6	nor	nor	CCONJ	CC	_	_	_	_	_
7	AZT	Azt	ADV	RB	_	_	_	_	_
8	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	under	under	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3886
# text = Ascorbate and AZT also had no effect on NF-kappa B activation following TNF-alpha- or PMA-induced stimulation of U1 promonocytic cells.
1	Ascorbate	Ascorbate	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	AZT	AZT	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	U1	U1	NUM	CD	NumType=Card	_	_	_	_
26	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3887
# text = These results suggest that the molecular mechanism of HIV inhibition by ascorbate is not mediated via NF-kappa B inhibition, unlike that seen with other antioxidants.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	unlike	unlike	ADP	IN	_	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	seen	see	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3888
# text = Document 003001273 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001273	003001273	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3889
# text = Paradoxical priming effects of IL-10 on cytokine production.
1	Paradoxical	Paradoxical	ADJ	JJ	Degree=Pos	_	_	_	_
2	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3890
# text = IL-10 is a well-known immunosuppressive and/or anti-inflammatory cytokine.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	or	or	CCONJ	CC	_	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3891
# text = However, we report in vitro experimental studies in which IL-10 primed leukocytes and led to an enhanced production of tumor necrosis factor (TNF) upon further stimulation by lipopolysaccharide (LPS).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
7	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	upon	upon	ADP	IN	_	_	_	_	_
30	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3892
# text = Monocytes and peripheral blood mononuclear cells (PBMC) prepared from whole blood maintained for 20
1	Monocytes	Monocyte	PROPN	NNPS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	prepared	prepare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	20	20	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 3893
# text = h at 37 degrees C in the presence of recombinant human IL-10 had an enhanced capacity to produce TNF in response to LPS.
1	h	h	INTJ	UH	_	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	37	37	NUM	CD	NumType=Card	_	_	_	_
4	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
21	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3894
# text = In addition to TNF, LPS-induced IL-6 and spontaneous IL-1ra production were also enhanced.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	ra	ra	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3895
# text = When isolated PBMC were first cultured for 20 h in the presence of IL-10 on Teflon to prevent adherence, washed to remove IL-10 and then further cultured in plastic dishes for an additional 20 h in the presence of LPS or IL-1beta, an enhanced release of TNF was observed.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	first	first	ADV	RB	_	_	_	_	_
6	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	_
9	h	h	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
21	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	washed	wash	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	remove	remove	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	then	then	ADV	RB	PronType=Dem	_	_	_	_
31	further	further	ADV	RB	_	_	_	_	_
32	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
35	dishes	dish	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
39	20	20	NUM	CD	NumType=Card	_	_	_	_
40	h	h	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
46	or	or	CCONJ	CC	_	_	_	_	_
47	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	release	release	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
56	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
57	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3896
# text = This was not the case when PBMC were pre-cultured in plastic multidishes in the presence of IL-10.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	case	case	NOUN	NN	Number=Sing	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	pre-cultured	pre-culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
12	multidishes	multidish	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3897
# text = TNF mRNA expression induced by LPS was decreased when the pre-treatment of PBMC with IL-10 was performed on plastic, whereas this was not the case when cells were pre-cultured with IL-10 on Teflon.
1	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	case	case	NOUN	NN	Number=Sing	_	_	_	_
29	when	when	ADV	WRB	PronType=Int	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	pre-cultured	pre-culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	10	10	NUM	CD	NumType=Card	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3898
# text = Furthermore, NFkappaB translocation following LPS activation was higher after IL-10 pre-treatment on Teflon than on plastic.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3899
# text = Interestingly, an enhanced frequency of CD16 and CD68(+) cells among the CD14(+) cells was observed in the presence of IL-10, independently of the pre-culture conditions of the PBMC.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD68	Cd68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	+)	+)	PUNCT	-RRB-	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	among	among	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD14	Cd14	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	+)	+)	PUNCT	-RRB-	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	independently	independently	ADV	RB	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	pre-culture	pre-culture	ADJ	JJ	Degree=Pos	_	_	_	_
33	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3900
# text = Altogether, these results indicate that the IL-10-induced up-regulation of cytokine production depends on the prevention of monocyte adherence by red cells in the whole blood assays or by cultures of PBMC on Teflon.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
25	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
32	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
33	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3901
# text = In contrast, the adherence parameter has no effect on the IL-10-induced modulation of some monocyte surface markers.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
6	parameter	parameter	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3902
# text = Document 003001274 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001274	003001274	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3903
# text = Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	FOSB	Fosb	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	G0S3	G0S3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3904
# text = G0S3 is a member of a set of putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from human blood mononuclear cells cultured for 2 hr with lectin and cycloheximide.
1	G0S3	G0S3	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	member	member	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	set	set	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	G0/G1	G0/G1	PROPN	NNP	Number=Sing	_	_	_	_
11	switch	switch	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	G0	G0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	S	S	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	screening	scree	VERB	VBG	VerbForm=Ger	_	_	_	_
22	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
23	libraries	library	NOUN	NNS	Number=Plur	_	_	_	_
24	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
28	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3905
# text = The sequence shows high homology with the murine FOSB gene, which encodes a component of the AP1 transcriptional regulator.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
9	FOSB	Fosb	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3906
# text = Comparison of cDNA and genomic sequences reveals a 4-exon structure characteristic of the FOS family of genes.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
7	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
12	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
13	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	FOS	FOS	ADJ	JJ	Degree=Pos	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3907
# text = Freshly isolated cells show high levels of FOSB/G0S3 and FOS/G0S7 mRNAs, which decline rapidly during incubation in culture medium.
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/G0S3	/G0S3	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	FOS	FOS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	/G0S7	/G0S7	NOUN	NN	Number=Sing	_	_	_	_
13	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	decline	decline	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
22	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3908
# text = The kinetics of expression suggest that the high initial levels are caused by the isolation procedure, and do not reflect constitutive expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
16	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	reflect	reflect	VERB	VB	VerbForm=Inf	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3909
# text = In cells preincubated for a day, levels of FOS mRNA reach a maximum 20 min after the addition of lectin and decline to control levels over the next 3 hr.
1	In	in	ADP	IN	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	day	day	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
15	20	20	NUM	CD	NumType=Card	_	_	_	_
16	min	min	NOUN	NNS	Number=Plur	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	over	over	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	next	next	ADJ	JJ	Degree=Pos	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3910
# text = Levels of FOSB mRNA reach a maximum 40 min after the addition of lectin and decline to control levels over the next 6 hr.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
8	40	40	NUM	CD	NumType=Card	_	_	_	_
9	min	min	NOUN	NNS	Number=Plur	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	over	over	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	next	next	ADJ	JJ	Degree=Pos	_	_	_	_
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3911
# text = In freshly isolated cells, both FOS and FOSB mRNAs increase dramatically in response to the protein synthesis inhibitor cycloheximide.
1	In	in	ADP	IN	_	_	_	_	_
2	freshly	freshly	ADV	RB	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNAs	mRNAs	PROPN	NNP	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	dramatically	dramatically	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3912
# text = In preincubated cells, the cycloheximide response is decreased, especially in the case of FOSB.
1	In	in	ADP	IN	_	_	_	_	_
2	preincubated	preincubate	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	especially	especially	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	case	case	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3913
# text = These differences in expression of FOS and FOSB suggest different roles and regulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
9	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3914
# text = Regions of low base order-dependent stem-loop potential in the region of the gene are defined.
1	Regions	region	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	base	base	NOUN	NN	Number=Sing	_	_	_	_
5	order	order	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	stem	stem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
11	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3915
# text = These indicate where base order has been adapted for purposes other than stem-loop stability (e.g., encoding proteins or gene regulation).
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	where	where	ADV	WRB	PronType=Int	_	_	_	_
4	base	base	NOUN	NN	Number=Sing	_	_	_	_
5	order	order	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	adapted	adapt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	purposes	purpose	NOUN	NNS	Number=Plur	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	stem	stem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
16	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3916
# text = Regions of low potential in a 68.5-kb genomic segment containing the FOSB gene suggest that the potential may help locate genes in uncharted DNA sequences.
1	Regions	region	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	68.5	68.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
10	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
11	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
22	locate	locate	VERB	VB	VerbForm=Inf	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	uncharted	uncharted	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3917
# text = Document 003001275 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001275	003001275	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3918
# text = Biphasic control of NF-kappa B activation induced by the triggering of HLA-DR antigens expressed on B cells.
1	Biphasic	Biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
17	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3919
# text = The regulation of NF-kappa B activation following the triggering of HLA-DR antigens by mAb L243 has been studied at various times in Raji cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
16	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
19	L243	L243	NOUN	NN	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
25	times	time	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3920
# text = Electrophoretic mobility shift assays demonstrated a strong increase of NF-kappa B DNA binding after triggering of HLA-DR antigens.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	ADV	RB	_	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	after	after	SCONJ	IN	_	_	_	_	_
17	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
22	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3921
# text = Using TNF-alpha-activity neutralizing antibodies, the authors demonstrated that the upregulation of NF-kappa B was found to depend, at later time point, on an autocrine effect of TNF-alpha secreted following triggering of HLA-DR antigens.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	alpha-activity	alpha-activity	NOUN	NN	Number=Sing	_	_	_	_
5	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
6	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	authors	author	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	later	later	ADV	RB	_	_	_	_	_
26	time	time	NOUN	NN	Number=Sing	_	_	_	_
27	point	point	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	autocrine	autocrine	ADJ	JJ	Degree=Pos	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	alpha	alpha	ADV	RB	_	_	_	_	_
37	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
39	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
44	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3922
# text = In contrast, it was found to be TNF-alpha independent in the early time point.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	alpha	alpha	ADV	RB	_	_	_	_	_
12	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	point	point	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3923
# text = Moreover, the upregulation of NF-kappa B binding activity is regulated by the triggering of selected epitopes of HLA-DR antigens.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
24	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3924
# text = In fact, mAb L243 but not the staphylococcal superantigens, staphylococcal exotoxin toxic shock syndrome toxin-I or staphylococcal enterotoxin B, regulate the NF-kappa B binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
5	L243	L243	NUM	CD	NumType=Card	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
10	superantigens	superantigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
13	exotoxin	exotoxin	ADP	IN	_	_	_	_	_
14	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
17	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
22	enterotoxin	enterotoxin	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3925
# text = Document 003001276 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001276	003001276	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3926
# text = Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc [published erratum appears in J Biol Chem 1996 Dec 27;271(52):33705]
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	member	member	NOUN	NN	Number=Sing	_	_	_	_
20	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
24	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	J	j	PROPN	NNP	Number=Sing	_	_	_	_
27	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
28	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
29	1996	1996	NUM	CD	NumType=Card	_	_	_	_
30	Dec	Dec	PROPN	NNP	Number=Sing	_	_	_	_
31	27;271	27;271	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	52)	52)	SYM	NFP	_	_	_	_	SpaceAfter=No
34	:33705	:33705	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3927
# text = The cyclosporin A (CsA)/FK506-sensitive nuclear factor of activated T cells (NFAT) plays a key role in the inducible expression of cytokine genes in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
3	A	a	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	/FK506	/FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-sensitive	-sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3928
# text = Although NFAT has been recently shown to be inducible in several non-T immune cells, the NFAT gene family members characterized to date have been isolated only from T cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	recently	recently	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	non-T	non-t	ADJ	JJ	Degree=Pos	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	date	date	NOUN	NN	Number=Sing	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	T	T	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3929
# text = To further characterize NFAT function in human B cells and to demonstrate cytokine gene specificity of NFAT proteins, we report here the isolation and characterization of a cDNA clone from the Raji B cell line.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	here	here	ADV	RB	PronType=Dem	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
30	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3930
# text = The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	member	member	NOUN	NN	Number=Sing	_	_	_	_
17	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	here	here	ADV	RB	PronType=Dem	_	_	_	_
21	NFATc.alpha	NFATc.alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3931
# text = The amino acid sequence of NFATc.beta differs from that of NFATc.alpha in the first NH2-terminal 29 residues and contains an additional region of 142 residues at the COOH terminus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amino	amino	DET	DT	_	_	_	_	_
3	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	_
7	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFATc.alpha	NFATc.alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
15	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	29	29	NUM	CD	NumType=Card	_	_	_	_
19	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	142	142	NUM	CD	NumType=Card	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	COOH	COOH	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
31	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3932
# text = Northern analysis using a probe encompassing a common region of both isoforms showed two mRNA species of 2.7 and 4.5 kilobase pairs, while an NFATc.beta-specific probe detected only the 4.5-kilobase pair mRNA which was preferentially expressed in the spleen.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
6	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	species	species	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	2.7	2.7	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	4.5	4.5	NUM	CD	NumType=Card	_	_	_	_
21	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
22	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
29	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	4.5	4.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
35	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
36	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
37	which	which	PRON	WDT	PronType=Rel	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	preferentially	preferentially	ADV	RB	_	_	_	_	_
40	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3933
# text = Transient expression of NFATc.beta was capable of activating an interleukin-2 NFAT-driven reporter gene in stimulated Jurkat cells in a CsA-sensitive manner.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	stimulated	stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3934
# text = However, NFATc.beta neither bound to the kappa3 element ( an NFAT-binding site ) in the tumor necrosis factor-alpha promoter nor activated the tumor necrosis factor-alpha promoter in cotransfection assays.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	_
4	neither	neither	DET	DT	_	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	kappa3	kappa3	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	nor	nor	CCONJ	CC	_	_	_	_	_
26	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
36	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3935
# text = These data suggest that different members or isoforms of NFAT gene family may regulate inducible expression of different cytokine genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	members	member	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3936
# text = Document 003001277 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001277	003001277	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3937
# text = Activation of nuclear factor kappa B in human neuroblastoma cell lines.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3938
# text = The nuclear factor kappa B (NF-kappa B) is a eukaryotic transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3939
# text = In B cells and macrophages it is constitutively present in cell nuclei, whereas in many other cell types, NF-kappa B translocates from cytosol to nucleus as a result of transduction by tumor necrosis factor alpha (TNF alpha), phorbol ester, and other polyclonal signals.
1	In	in	ADP	IN	_	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	translocates	translocate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	nucleus	nucleus	VERB	VB	VerbForm=Inf	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	result	result	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
46	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
50	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
51	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3940
# text = Using neuroblastoma cell lines as models, we have shown that in neural cells NF-kappa B was present in the cytosol and translocated into nuclei as a result of TNF alpha treatment.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	neural	neural	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	into	into	ADP	IN	_	_	_	_	_
27	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	result	result	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
33	alpha	alpha	ADP	IN	_	_	_	_	_
34	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3941
# text = The TNF alpha-activated NF-kappa B was transcriptionally functional.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
3	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3942
# text = NF-kappa B activation by TNF alpha was not correlated with cell differentiation or proliferation.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3943
# text = However, reagents such as nerve growth factor (NGF) and the phorbol ester phorbol 12-myristate 13-acetate (PMA), which induce phenotypical differentiation of the SH-SY5Y neuroblastoma cell line, activated NF-kappa B, but only in that particular cell line.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	reagents	reagent	NOUN	NNS	Number=Plur	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	nerve	nerve	ADJ	JJ	Degree=Pos	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
20	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
22	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	phenotypical	phenotypical	ADJ	JJ	Degree=Pos	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	SH	Sh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	SY5Y	SY5y	NOUN	NN	Number=Sing	_	_	_	_
36	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	but	but	CCONJ	CC	_	_	_	_	_
47	only	only	ADV	RB	_	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
50	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3944
# text = In a NGF-responsive rat pheochromocytoma cell line, PC12, PMA activated NF-kappa B, whereas NGF did not.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	pheochromocytoma	pheochromocytoma	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	PC12	Pc12	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	whereas	whereas	SCONJ	IN	_	_	_	_	_
21	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3945
# text = In other neuroblastoma cell lines, such as SK-N-Be(2), the lack of PMA induction of differentiation was correlated with the lack of NF-kappa B activation.
1	In	in	ADP	IN	_	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	SK	SK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Be	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3946
# text = We found, moreover, that in SK-N-Be(2) cells protein kinase C (PKC) enzymatic activity was much lower compared with that in a control cell line and that the low PKC enzymatic activity was due to low PKC protein expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	SK	SK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Be	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	much	much	ADV	RB	_	_	_	_	_
27	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	control	control	NOUN	NN	Number=Sing	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
40	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
41	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	due	due	ADP	IN	_	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
47	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3947
# text = NF-kappa B was not activated by retinoic acid, which induced morphological differentiation of all the neuroblastoma cell lines used in the present study.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	all	all	DET	PDT	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
22	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3948
# text = Thus, NF-kappa B activation was not required for neuroblastoma cell differentiation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3949
# text = Furthermore, the results obtained with TNF alpha proved that NF-kappa B activation was not sufficient for induction of neuroblastoma differentiation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	ADV	RB	_	_	_	_	_
9	proved	prove	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3950
# text = Document 003001278 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001278	003001278	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3951
# text = Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.
1	Tap	tap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	tip	tip	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
13	saimiri	saimirus	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
16	lymphocyte	lymphocyte	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3952
# text = Tip of herpesvirus saimiri associates with Lck and down-regulates Lck-mediated activation.
1	Tip	tip	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
4	saimiri	saimiri	NOUN	NN	Number=Sing	_	_	_	_
5	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	Lck-mediated	Lck-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3953
# text = We identified a novel cellular Tip-associated protein (Tap) by a yeast two-hybrid screen.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
6	Tip	tip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Tap	tap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
18	screen	screen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3954
# text = Tap associated with Tip following transient expression in COS-1 cells and stable expression in human Jurkat-T cells.
1	Tap	tap	NOUN	NN	Number=Sing	_	_	_	_
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	Tip	tip	PROPN	NNP	Number=Sing	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3955
# text = Expression of Tip and Tap in Jurkat-T cells induced dramatic cell aggregation.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Tip	tip	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Tap	tap	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3956
# text = Aggregation was likely caused by the up-regulated surface expression of adhesion molecules including integrin alpha, L-selectin, ICAM-3, and H-CAM.
1	Aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	likely	likely	ADV	RB	_	_	_	_	_
4	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	integrin	integrin	ADP	IN	_	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	L-selectin	L-selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CAM	CAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3957
# text = Furthermore, NF-kappaB transcriptional factor of aggregated cells had approximately 40-fold higher activity than that of parental cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	aggregated	aggregated	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3958
# text = Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tap	tap	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tip	tip	NOUN	NN	Number=Sing	_	_	_	_
14	function	function	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
21	saimiri	saimiri	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3959
# text = Document 003001279 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001279	003001279	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3960
# text = Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	ADP	IN	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	JUN	JUN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3961
# text = The human tumor necrosis factor alpha (TNF-alpha) gene is one of the earliest genes transcribed after the stimulation of a B cell through its antigen receptor or via the CD-40 pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	via	via	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	40	40	NUM	CD	NumType=Card	_	_	_	_
37	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3962
# text = In both cases, induction of TNF-alpha gene transcription can be blocked by the immunosuppressants cyclosporin A and FK506, which suggested a role for the NFAT family of proteins in the regulation of the gene in B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
18	cyclosporin	cyclosporin	ADP	IN	_	_	_	_	_
19	A	a	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3963
# text = Furthermore, in T cells, two molecules of NFATp bind to the TNF-alpha promoter element kappa 3 in association with ATF-2 and Jun proteins bound to an immediately adjacent cyclic AMP response element (CRE) site.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
11	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	association	association	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	immediately	immediately	ADV	RB	_	_	_	_	_
34	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
35	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
36	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	element	element	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3964
# text = Here, using the murine B-cell lymphoma cell line A20, we show that the TNF-alpha gene is regulated in a cell-type-specific manner.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	A20	A20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3965
# text = In A20 B cells, the TNF-alpha gene is not regulated by NFATp bound to the kappa 3 element.
1	In	in	ADP	IN	_	_	_	_	_
2	A20	A20	NUM	CD	NumType=Card	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3966
# text = Instead, ATF-2 and Jun proteins bind to the composite kappa 3/CRE site and NFATp binds to a newly identified second NFAT site centered at -76 nucleotides relative to the TNF-alpha transcription start site.
1	Instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	composite	composite	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	3/CRE	3/cre	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	_
18	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	newly	newly	ADV	RB	_	_	_	_	_
22	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
24	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	76	76	NUM	CD	NumType=Card	_	_	_	_
30	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
31	relative	relative	ADV	RB	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	start	start	NOUN	NN	Number=Sing	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3967
# text = This new site plays a critical role in the calcium-mediated, cyclosporin A-sensitive induction of TNF-alpha in both A20 B cells and Ar-5 cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	calcium-	calcium-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	A20	A20	NUM	CD	NumType=Card	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ar	ar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	5	5	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3968
# text = Consistent with these results, quantitative DNase footprinting of the TNF-alpha promoter using increasing amounts of recombinant NFATp demonstrated that the -76 site binds to NFATp with a higher affinity than the kappa 3 site.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
8	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
17	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
20	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
21	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	76	76	NUM	CD	NumType=Card	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	_
27	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	NFATp	NFATp	VERB	VB	VerbForm=Inf	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
33	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
34	than	than	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	3	3	NUM	CD	NumType=Card	_	_	_	_
38	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3969
# text = Two other previously unrecognized NFATp-binding sites in the proximal TNF-alpha promoter were also identified by this analysis.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	unrecognized	unrecognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3970
# text = Thus, through the differential use of the same promoter element, the composite kappa 3/CRE site, the TNF-alpha gene is regulated in a cell-type-specific manner in response to the same extracellular signal.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	3/CRE	3/cre	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
37	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
38	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3971
# text = Document 003001280 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001280	003001280	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3972
# text = Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
25	method	method	NOUN	NN	Number=Sing	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
27	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	assay	assay	VERB	VB	VerbForm=Inf	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3973
# text = Nuclear factor of activated T-cells (NFAT-1) is a transcription factor which is considered to be an important regulator in early T-cell activation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3974
# text = We have developed a system to monitor the transcriptional activity of NFAT-1 at the single cell level in whole animals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	system	system	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
22	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3975
# text = The system is based on the use of an oligomerized NFAT-1 binding motif that directs transcription of SV40 T-antigen in transgenic mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	system	system	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	oligomerized	oligomerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
21	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3976
# text = This report represents the first demonstration that a multimerized short binding motif can function appropriately in transgenic mice.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	report	report	NOUN	NN	Number=Sing	_	_	_	_
3	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
15	appropriately	appropriately	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3977
# text = NFAT-1 activity had previously been thought to be confined to activated T-lymphocytes upon release of intracellular calcium.
1	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	previously	previously	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	release	release	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3978
# text = By targeting NFAT-1-dependent gene expression in transgenic mice we discovered new sites of NFAT-1 activity.
1	By	by	SCONJ	IN	_	_	_	_	_
2	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
3	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	discovered	discover	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3979
# text = Besides in T-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C.
1	Besides	besides	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	spleen	spleen	NOUN	NNS	Number=Plur	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	release	release	NOUN	NN	Number=Sing	_	_	_	_
31	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3980
# text = A difference in the time course of appearance of NFAT-1 activity between T-lymphocytes and non-T-lymphocytes was revealed.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	time	time	NOUN	NN	Number=Sing	_	_	_	_
6	course	course	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	non-T-	non-t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3981
# text = Constitutive expression was observed in a small population of cells in the dermis and some mice have developed skin lesions.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
8	population	population	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	dermis	dermis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	skin	skin	ADJ	JJ	Degree=Pos	_	_	_	_
20	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3982
# text = Interestingly, the tissue pattern of expression of the NFAT-1 activity resembles the expression pattern described for HIV-LTR/tat transgenic mice (Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., and Jay, G. (1988) Nature 335, 606-611).
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
5	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	resembles	resemble	NOUN	NNS	Number=Plur	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
18	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
25	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Vogel	Vogel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	J.	J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	Hinrichs	Hinrichs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
35	H.	H.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	Reynolds	Reynolds	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	R.	R.	PROPN	NNP	Number=Sing	_	_	_	_
40	K.	K.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	Luciw	Luciw	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	P.	P.	PROPN	NNP	Number=Sing	_	_	_	_
45	A.	A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	Jay	Jay	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	1988	1988	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	Nature	nature	NOUN	NN	Number=Sing	_	_	_	_
55	335	335	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	606-611	606-611	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3983
# text = This similarity in expression and the fact that NFAT-1 has been shown to bind functional sequences in HIV-LTR suggest a role for NFAT-1 in dermal activation of the HIV-LTR.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	ADV	WRB	PronType=Rel	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
17	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
23	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	dermal	dermal	ADJ	JJ	Degree=Pos	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3984
# text = Document 003001281 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001281	003001281	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3985
# text = The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
3	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3986
# text = All immunoglobulin genes contain a conserved octanucleotide promoter element, ATGCAAAT, which has been shown to be required for their normal B-cell-specific transcription.
1	All	all	DET	DT	_	_	_	_	_
2	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	octanucleotide	octanucleotide	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	ATGCAAAT	ATGCAAAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3987
# text = Proteins that bind this octamer have been purified, and cDNAs encoding octamer-binding proteins have been cloned.
1	Proteins	Protein	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cDNAs	cDNAs	SCONJ	IN	_	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3988
# text = Some of these proteins (referred to as OTF-2) are lymphoid specific, whereas at least one other, and possibly more (referred to as OTF-1), is found ubiquitously in all cell types.
1	Some	some	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	ADV	RB	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	possibly	possibly	ADV	RB	_	_	_	_	_
25	more	more	ADV	RBR	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	all	all	DET	DT	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3989
# text = The exact role of these different proteins in directing the tissue-specific expression of immunoglobulin genes is unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3990
# text = We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	pre-B	pre-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	extremely	extremely	ADV	RB	_	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	yet	yet	CCONJ	CC	_	_	_	_	_
20	still	still	ADV	RB	_	_	_	_	_
21	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	state	state	NOUN	NN	Number=Sing	_	_	_	_
28	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
29	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-chain	-chain	ADJ	JJ	Degree=Pos	_	_	_	_
31	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	efficiently	efficiently	ADV	RB	_	_	_	_	_
36	transcribe	transcribe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3991
# text = Addition of a highly enriched preparation of OTF-1 made from one of these pre-B cells or from HeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	highly	highly	ADV	RB	_	_	_	_	_
5	enriched	enriched	ADJ	JJ	Degree=Pos	_	_	_	_
6	preparation	preparation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	made	make	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
17	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3992
# text = Furthermore, OFT-1 appeared to have approximately the same transactivation ability as OTF-2 when normalized for binding activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	OFT	OFT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
9	approximately	approximately	ADV	RB	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	normalized	normalized	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3993
# text = These results suggest that OTF-1, without OTF-2, is sufficient for transcription of immunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	without	without	ADP	IN	_	_	_	_	_
10	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	OTF	Otf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	alone	alone	ADV	RB	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3994
# text = Document 003001282 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001282	003001282	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3995
# text = alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization.
1	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Tocopheryl	Tocopheryl	PROPN	NNP	Number=Sing	_	_	_	_
4	succinate	succinate	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3996
# text = The adherence of monocytes to activated endothelium is an early event in atherogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	event	event	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3997
# text = Because antioxidants have been considered to be of antiatherosclerotic potential, we investigated the effects of alpha-tocopherol (TCP) and its acetate and succinate esters on monocyte adhesion to cytokine-stimulated human umbilical vein endothelial cells (HUVEC).
1	Because	because	SCONJ	IN	_	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	antiatherosclerotic	antiatherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	succinate	succinate	ADJ	JJ	Degree=Pos	_	_	_	_
28	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
38	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
39	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3998
# text = Endothelial cells were treated with TCP, alpha-tocopherol acetate (TCP acetate), or alpha-tocopheryl succinate (TCP succinate) before stimulation with tumor necrosis factor-alpha (TNF-alpha; 10 U/ml, 6 h) or interleukin-1 beta (IL-1 beta; 10 U/ml, 6 h).
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
11	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
14	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	tocopheryl	tocopheryl	NOUN	NN	Number=Sing	_	_	_	_
21	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	_
24	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	before	before	ADP	IN	_	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
30	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	;	;	PUNCT	,	_	_	_	_	_
39	10	10	NUM	CD	NumType=Card	_	_	_	_
40	U/ml	u/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	;	;	PUNCT	,	_	_	_	_	_
56	10	10	NUM	CD	NumType=Card	_	_	_	_
57	U/ml	u/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	6	6	NUM	CD	NumType=Card	_	_	_	_
60	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3999
# text = Cytokine-stimulated cell surface expression of vascular cell adhesion molecule-1 (VCAM-1, CD106) and E-selectin (ELAM-1, CD62E), but not of intercellular adhesion molecule-1 (ICAM-1, CD54), was time- and dose-dependently inhibited by TCP succinate but not by TCP or TCP acetate.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	CD106	CD106	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ELAM	ELAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD62E	CD62E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	not	not	ADV	RB	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	CD54	CD54	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	dependently	dependently	ADV	RB	_	_	_	_	_
54	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
57	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
58	but	but	CCONJ	CC	_	_	_	_	_
59	not	not	ADV	RB	_	_	_	_	_
60	by	by	ADP	IN	_	_	_	_	_
61	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
62	or	or	CCONJ	CC	_	_	_	_	_
63	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
64	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4000
# text = TCP succinate (200 microM, 24 h) reduced TNF-induced VCAM-1 and E-selectin expression from a specific mean fluorescence intensity of 151 +/- 28 to 12 +/- 4 channels and from 225 +/- 38 to 79 +/- 21 channels, respectively.
1	TCP	TCp	SYM	NFP	_	_	_	_	_
2	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	200	200	NUM	CD	NumType=Card	_	_	_	_
5	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	24	24	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	mean	mean	NOUN	NN	Number=Sing	_	_	_	_
25	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
26	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	151	151	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	28	28	NUM	CD	NumType=Card	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	12	12	NUM	CD	NumType=Card	_	_	_	_
33	+/-	+/-	SYM	SYM	_	_	_	_	_
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	225	225	NUM	CD	NumType=Card	_	_	_	_
39	+/-	+/-	SYM	SYM	_	_	_	_	_
40	38	38	NUM	CD	NumType=Card	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	79	79	NUM	CD	NumType=Card	_	_	_	_
43	+/-	+/-	SYM	SYM	_	_	_	_	_
44	21	21	NUM	CD	NumType=Card	_	_	_	_
45	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4001
# text = Succinate alone had no effect.
1	Succinate	Succinate	PROPN	NNP	Number=Sing	_	_	_	_
2	alone	alone	ADV	RB	_	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4002
# text = Decreased adhesion molecule expression was associated with a reduction of monocytic cell adhesion.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4003
# text = TCP succinate (20 microM, 72 h), but not TCP (200 microM, 72 h), reduced U-937 cell adhesion to TNF-alpha-stimulated (10 U/ml, 6 h) HUVEC by 30% (P < 0.025) and to IL-1 beta-stimulated HUVEC by 56% (P < 0.010).
1	TCP	TCp	SYM	NFP	_	_	_	_	_
2	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	20	20	NUM	CD	NumType=Card	_	_	_	_
5	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	72	72	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	200	200	NUM	CD	NumType=Card	_	_	_	_
16	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	72	72	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	937	937	NUM	CD	NumType=Card	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	6	6	NUM	CD	NumType=Card	_	_	_	_
40	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	HUVEC	HUVEC	NOUN	NN	Number=Sing	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	%	%	SYM	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	P	p	NOUN	NN	Number=Sing	_	_	_	_
48	<	<	PUNCT	-LRB-	_	_	_	_	_
49	0.025	0.025	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	HUVEC	Huvec	PROPN	NNP	Number=Sing	_	_	_	_
60	by	by	ADP	IN	_	_	_	_	_
61	56	56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	%	%	SYM	NN	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	P	p	NOUN	NN	Number=Sing	_	_	_	_
65	<	<	PUNCT	-LRB-	_	_	_	_	_
66	0.010	0.010	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4004
# text = Electrophoretic mobility-shift assays of HUVEC nuclear proteins revealed a decrease in TNF-alpha-stimulated nuclear factor-kappa B (NF-kappa B) activation after pretreatment of HUVEC with TCP succinate but not with TCP, TCP acetate, or succinate alone.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HUVEC	Huvec	ADJ	JJ	Degree=Pos	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
37	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
38	but	but	CCONJ	CC	_	_	_	_	_
39	not	not	ADV	RB	_	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	TCP	TCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	TCP	TCP	PROPN	NNP	Number=Sing	_	_	_	_
44	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	or	or	CCONJ	CC	_	_	_	_	_
47	succinate	succinate	VERB	VB	VerbForm=Inf	_	_	_	_
48	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4005
# text = In conclusion, we demonstrate that the vitamin E derivative TCP succinate prevents monocytic cell adhesion to cytokine-stimulated endothelial cells by inhibiting the activation of NF-kappa B, further emphasizing the antiatherosclerotic potential of lipid soluble antioxidants.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
9	E	e	NOUN	NN	Number=Sing	_	_	_	_
10	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
11	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	_
12	succinate	succinate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	further	further	SCONJ	IN	_	_	_	_	_
34	emphasizing	emphasize	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	antiatherosclerotic	antiatherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
37	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
40	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
41	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4006
# text = Document 003001283 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001283	003001283	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4007
# text = Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
18	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
19	A2	a2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4008
# text = In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2.
1	In	in	ADP	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	cytosolic	cytosolic	NOUN	NN	Number=Sing	_	_	_	_
15	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
16	A2	A2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4009
# text = This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
3	releases	release	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	lyso	lyso	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-phospholipids	-phospholipid	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	metabolized	metabolize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	eicosanoids	eicosanoid	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-activating	-activat	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	-factor	-factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4010
# text = These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
3	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
19	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
20	A2	a2	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
23	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4011
# text = We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	trifluoromethylketone	trifluoromethylketone	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
10	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4012
# text = A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.
1	A2	A2	PART	TO	Abbr=Yes	_	_	_	_
2	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	state	state	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4013
# text = In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Int	_	_	_	_
12	trifluoromethylketones	trifluoromethylketones	NOUN	NNS	Number=Plur	_	_	_	_
13	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4014
# text = We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNa	SYM	SYM	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4015
# text = Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4016
# text = Trifluoromethylketones ameliorate chronic inflammation in vivo.
1	Trifluoromethylketones	Trifluoromethylketone	NOUN	NNS	Number=Plur	_	_	_	_
2	ameliorate	ameliorate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
4	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4017
# text = Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
5	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	reside	reside	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
19	thereby	thereby	ADV	RB	_	_	_	_	_
20	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	interleukin	interleukin	ADV	RB	_	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4018
# text = Document 003001284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001284	003001284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4019
# text = The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4020
# text = The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	host	host	VERB	VB	VerbForm=Inf	_	_	_	_
7	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
32	component	component	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	development	development	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4021
# text = To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein.
1	To	to	PART	TO	_	_	_	_	_
2	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	protect	protect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
15	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	early	early	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-lytic	-lytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	distant	distant	ADJ	JJ	Degree=Pos	_	_	_	_
35	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	anti-apoptosis	anti-apoptosis	ADJ	JJ	Degree=Pos	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4022
# text = Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	MCF	MCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	nearly	nearly	ADV	RB	_	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	against	against	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	anti-Fas	anti-Fas	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4023
# text = In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	BHRF1	BHRF1	NUM	CD	NumType=Card	_	_	_	_
5	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	killing	kille	VERB	VBG	VerbForm=Ger	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
16	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	killing	kill	NOUN	NN	Number=Sing	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4024
# text = The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
7	MCF	MCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	xL	xL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4025
# text = Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	action	action	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
9	resembled	resemble	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	xL	xL	NOUN	NN	Number=Sing	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	anti-Fas-induced	anti-Fas-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
30	participating	participate	VERB	VBG	VerbForm=Ger	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
37	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4026
# text = A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors.
1	A2	A2	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	caspase-3/CPP32	caspase-3/CPP32	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4027
# text = A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	or	or	CCONJ	CC	_	_	_	_	_
26	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
27	-Fas	-Fas	ADV	RB	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	death	death	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	order	order	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	maximize	maximize	VERB	VB	VerbForm=Inf	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4028
# text = Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	neither	neither	DET	DT	_	_	_	_	_
6	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	CCONJ	CC	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	BJAB	BJAB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	protected	protect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	anti-Fas-	anti-Fas-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	even	even	ADV	RB	_	_	_	_	_
28	though	though	SCONJ	IN	_	_	_	_	_
29	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
30	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	starved	starve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4029
# text = Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	BHRF1	BHRF1	NUM	CD	NumType=Card	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	apoptosis	apoptosis	ADJ	JJ	Degree=Pos	_	_	_	_
10	resembles	resemble	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	ADV	WRB	PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	being	being	AUX	VBG	VerbForm=Ger	_	_	_	_
18	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
26	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4030
# text = Document 003001285 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001285	003001285	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4031
# text = In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	metalloproteinases	metalloproteinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4032
# text = Cellular pathways for induction of programmed cell death (PCD) have been identified, but little is known about specific extracellular matrix processes that may affect apoptosis along those pathways.
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PCD	pCd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	about	about	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
24	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
28	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	along	along	ADP	IN	_	_	_	_	_
30	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4033
# text = In this study, a series of Burkitt's lymphoma (BL) cell lines were assayed for their expression of tissue inhibitor of metalloproteinases (TIMP)-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	series	series	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
23	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	metalloproteinases	metalloproteinase	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TIMP	TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4034
# text = Results indicate that TIMP-1-positive BL lines show resistance to cold-shock-induced apoptosis.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
9	BL	Bl	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	cold	cold	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4035
# text = Furthermore, recombinant TIMP-1, but not TIMP-2 or a synthetic metalloproteinase inhibitor (BB-94), confers resistance to apoptosis induced by both CD95-dependent and -independent (cold shock, serum deprivation, and gamma-radiation) pathways in TIMP-1-negative BL lines.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
4	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
16	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	BB	bb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	94	94	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
25	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	CD95	Cd95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	cold	cold	ADJ	JJ	Degree=Pos	_	_	_	_
39	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
42	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	TIMP	TIMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
56	BL	Bl	NOUN	NN	Number=Sing	_	_	_	_
57	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4036
# text = TIMP-1 suppression of PCD is not due to metalloproteinase inhibition, as reduction and alkylation of the TIMP-1 did not abolish this activity.
1	TIMP	Timp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PCD	PCD	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	due	due	ADP	IN	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	alkylation	alkylation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	abolish	abolish	VERB	VB	VerbForm=Inf	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4037
# text = Retroviral induction of TIMP-1 not only resulted in cell survival but also in continued DNA synthesis for up to 5 d in the absence of serum, while controls underwent apoptosis.
1	Retroviral	Retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TIMP	TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	continued	continue	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	up	up	ADP	RP	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	_
23	d	d	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	while	while	SCONJ	IN	_	_	_	_	_
31	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
32	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4038
# text = This resistance to apoptosis is reversed by anti-TIMP-1 antibodies, demonstrating that secreted TIMP-1 is active in blocking apoptosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	anti-TIMP	anti-TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
23	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4039
# text = Furthermore, TIMP-1 upregulation induced expression of Bcl-XL but not Bcl-2 as well as decreased NF-kappaB activity as compared with controls.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TIMP	TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	XL	XL	PROPN	NNP	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4040
# text = These results demonstrate that TIMP-1 suppresses apoptosis in B cells and suggests a novel activity for TIMP-1 in tissue homeostasis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	TIMP	TIMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
24	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4041
# text = Document 003001286 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001286	003001286	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4042
# text = Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
1	Cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	core	core	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4043
# text = Tissue-specific expression of interleukin-3 (IL-3) is mediated via cis-acting elements located within 315 base pairs of the transcription start.
1	Tissue	Tissue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	3	3	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
18	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	315	315	NUM	CD	NumType=Card	_	_	_	_
23	base	base	NOUN	NN	Number=Sing	_	_	_	_
24	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	start	start	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4044
# text = This is achieved in part through the positive activities of the AP-1 and Elf-1 sites in the IL-3 promoter.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	part	part	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4045
# text = The contribution to T cell-specific expression by other promoter sites was assessed in a transient expression assay with IL-3 promoter constructs linked to a luciferase gene, focusing initially on the core binding factor (CBF) site, which is footprinted in vivo upon T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
26	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	focusing	focus	VERB	VBG	VerbForm=Ger	_	_	_	_
33	initially	initially	ADV	RB	_	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	core	core	NOUN	NN	Number=Sing	_	_	_	_
37	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	which	which	PRON	WDT	PronType=Rel	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	footprinted	footprint	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
49	upon	upon	ADP	IN	_	_	_	_	_
50	T	t	PROPN	NNP	Number=Sing	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4046
# text = Activity of the CBF site is shown to be critically dependent on the adjacent activator site Act-1.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	critically	critically	ADV	RB	_	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	Act	act	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4047
# text = Together the Act-1 and CBF sites form a functional unit (AC unit) with dual activity.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Act	act	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	form	form	ADP	IN	Typo=Yes	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	AC	Ac	NOUN	NN	Number=Sing	_	_	_	_
15	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4048
# text = The AC unit is demonstrated to enhance basal activity of promoters both in fibroblasts and T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AC	Ac	NOUN	NN	Number=Sing	_	_	_	_
3	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
8	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4049
# text = This activity is further inducible in activated T cells, but not in fibroblasts.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4050
# text = In addition to the already identified NIP repressor site, evidence is presented for a second repressor region that restricts promoter activity in fibroblasts.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	already	already	ADV	RB	_	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NIP	Nip	NOUN	NN	Number=Sing	_	_	_	_
8	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	restricts	restrict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4051
# text = Finally, a novel positive regulatory element has been mapped in the IL-3 promoter between nucleotide -180 and -210 that leads to increased expression in T cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	180	180	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	210	210	NUM	CD	NumType=Card	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	increased	increase	VERB	VB	VerbForm=Inf	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4052
# text = Together these results demonstrate that T cell expression of IL-3 is not specified by the activity of a single tissue-specific element, but instead involves multiple interacting elements that provide both specific positive regulation in T cells and specific negative regulation in fibroblasts.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	specified	specify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	instead	instead	ADV	RB	_	_	_	_	_
29	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
31	interacting	interacting	ADJ	JJ	Degree=Pos	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
38	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
44	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
45	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4053
# text = Document 003001287 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001287	003001287	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4054
# text = Relief of cyclin
1	Relief	relief	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4055
# text = A gene transcriptional inhibition during activation of human primary T lymphocytes via CD2 and CD28 adhesion molecules.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	NOUN	NN	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4056
# text = Cyclin
1	Cyclin	Cyclin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4057
# text = A transcription is cell cycle regulated and induced by cell proliferative signals.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4058
# text = To understand the mechanisms underlined in this regulation in normal human cells, we have analysed in vivo protein-DNA interactions at the Cyclin A locus in primary T lymphocytes.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	underlined	underlin	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Cyclin	Cyclin	PROPN	NNP	Number=Sing	_	_	_	_
26	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4059
# text = Stimulation of purified T lymphocytes by a combination of monoclonal antibodies directed at CD2 and CD28 adhesion molecules gives rise to a long lasting proliferation in the absence of accessory cells.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
12	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	gives	give	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	rise	rise	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	lasting	lasting	NOUN	NN	Number=Sing	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4060
# text = Cyclin
1	Cyclin	Cyclin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4061
# text = A was observed after 4 days of costimulation with anti CD2 + CD28 whereas stimulation by anti CD2 or anti CD28 alone was not effective.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	days	day	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anti	anti	X	AFX	_	_	_	_	_
11	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
12	+	+	SYM	SYM	_	_	_	_	_
13	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
14	whereas	whereas	NOUN	NNS	Number=Plur	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	anti	anti	X	AFX	_	_	_	_	_
18	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	anti	anti	X	AFX	_	_	_	_	_
21	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
22	alone	alone	ADV	RB	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4062
# text = In vivo genomic DMS footprinting revealed upstream of the major transcription initiation sites, the presence of at least three protein binding sites, two of which were constitutively occupied.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
4	DMS	Dm	NOUN	NNS	Number=Plur	_	_	_	_
5	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
6	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	three	three	NUM	CD	NumType=Card	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	constitutively	constitutively	ADV	RB	_	_	_	_	_
30	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4063
# text = They bind in vitro respectively ATF-1 and NF-Y proteins.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
5	respectively	respectively	ADV	RB	_	_	_	_	_
6	ATF	Atf	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Y	y	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4064
# text = The third site was occupied in quiescent cells or in cells stimulated by anti CD2 or anti CD28 alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	anti	anti	X	AFX	_	_	_	_	_
15	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	anti	anti	X	AFX	_	_	_	_	_
18	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
19	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4065
# text = The mitogenic combination of anti CD2 + anti CD28 released the footprint as cells were committed to proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
3	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	anti	anto	X	AFX	_	_	_	_	_
6	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
7	+	+	SYM	SYM	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4066
# text = Consistent with theses results, nuclear extracts prepared from quiescent cells formed a specific complex with this element, whereas extracts prepared from cells treated with anti CD2 + anti CD28 failed to do so after cells entered a proliferative state.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
4	s	's	PART	POS	_	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
23	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	anti	anti	X	AFX	_	_	_	_	_
29	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
30	+	+	SYM	SYM	_	_	_	_	_
31	anti	anti	X	AFX	_	_	_	_	_
32	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
33	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	do	do	VERB	VB	VerbForm=Inf	_	_	_	_
36	so	so	ADV	RB	_	_	_	_	_
37	after	after	SCONJ	IN	_	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	entered	enter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
42	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4067
# text = Document 003001288 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001288	003001288	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4068
# text = A factor known to bind to endogenous
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	endogenous	endogenous	X	ADD	_	_	_	_	_

# sent_id = 4069
# text = Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphocytes	lymphocytes	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4070
# text = The transcriptional enhancer located in the first intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4071
# text = Like other enhancers, the Ig heavy chain enhancer contains several short sequence motifs that bind specific transcription factors.
1	Like	like	ADP	IN	_	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
7	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4072
# text = Each binding site contributes to the overall activity of the enhancer, however no single element seems absolutely required for activity.
1	Each	each	DET	DT	_	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	absolutely	absolutely	ADV	RB	_	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4073
# text = For a better understanding of the
1	For	for	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
4	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_

# sent_id = 4074
# text = Ig heavy chain enhancer components, we have cloned and analyzed individual sequence elements.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4075
# text = We find that the factor that binds to the E3 enhancer motif, CATGTGGC, is a ubiquitous transcription factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CATGTGGC	CATGTGGC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4076
# text = It is present in an active form in both B cells and non-B cells, where it can mediate transcriptional activation in vitro and in vivo.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	non	non	X	AFX	_	_	_	_	SpaceAfter=No
14	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4077
# text = However, despite its ability to activate transcription of a transfected reporter gene, the factor is apparently unable to bind to the endogenous
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	despite	despite	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	apparently	apparently	ADV	RB	_	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	endogenous	endogenous	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4078
# text = Ig heavy chain enhancer in non-lymphoid cells:
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	non-lymphoid	non-lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4079
# text = In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3, was detected in B cells but not in non-B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
11	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	muE3	muE3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	non	non	X	AFX	_	_	_	_	SpaceAfter=No
30	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4080
# text = From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes: (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa
1	From	from	ADP	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	picture	picture	NOUN	NN	Number=Sing	_	_	_	_
8	emerges	emerge	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	there	there	PRON	EX	_	_	_	_	_
11	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	three	three	NUM	CD	NumType=Card	_	_	_	_
15	categories	category	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	a	a	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2B	2b	NOUN	NN	Number=Sing	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	not	not	PART	RB	_	_	_	_	_
47	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
50	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	:	:	PUNCT	:	_	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	b	b	X	LS	_	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
58	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
59	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
60	as	as	ADP	IN	_	_	_	_	_
61	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4081
# text = B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors, exemplified by the one binding to the E3 sequence motif.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
15	form	form	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	c	c	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	exemplified	exemplify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	one	one	NOUN	NN	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
35	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
36	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4082
# text = This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	form	form	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	types	type	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	apparently	apparently	ADV	RB	_	_	_	_	_
18	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	endogenous	endogenous	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4083
# text = Ig heavy chain enhancer in non-B cells, perhaps due to a non-permissive chromatin structure of the Ig heavy chain locus.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	non	non	X	AFX	_	_	_	_	SpaceAfter=No
7	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	perhaps	perhaps	ADV	RB	_	_	_	_	_
11	due	due	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	non-permissive	non-permissive	ADJ	JJ	Degree=Pos	_	_	_	_
15	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
20	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4084
# text = Document 003001289 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001289	003001289	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4085
# text = Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4086
# text = Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood.
1	Malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
2	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
3	usually	usually	ADV	RB	_	_	_	_	_
4	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4087
# text = PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	some	some	DET	DT	_	_	_	_	_
18	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4088
# text = PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
18	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	transgenesis	transgenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	erythroleukemias	erythroleukemia	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4089
# text = Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation.
1	Restoration	restoration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
8	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	MEL	MEL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PU.1	PU.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4090
# text = Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
9	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4091
# text = We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
5	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
14	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4092
# text = Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
9	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4093
# text = PU.1 represses GATA-1-mediated transcriptional activation.
1	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
2	represses	represse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4094
# text = Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	needed	need	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
22	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	MEL	Mel	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4095
# text = We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Xenopus	Xenopus	PROPN	NNP	Number=Sing	_	_	_	_
11	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
16	erythropoiesis	erythropoiesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4096
# text = Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
6	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	MEL	Mel	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Xenopus	Xenopus	ADJ	JJ	Degree=Pos	_	_	_	_
14	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	explants	explant	NOUN	NNS	Number=Plur	_	_	_	_
17	relieves	relieve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	block	block	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	erythroid	erythroid	VERB	VB	VerbForm=Inf	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	imposed	impose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4097
# text = Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	stoichiometry	stoichiometry	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	_
9	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	opposing	oppos	VERB	VBG	VerbForm=Ger	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
18	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
19	governing	govern	VERB	VBG	VerbForm=Ger	_	_	_	_
20	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
26	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4098
# text = Document 003001290 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001290	003001290	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4099
# text = Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Chlamydia	Chlamydia	PROPN	NNP	Number=Sing	_	_	_	_
12	pneumoniae	pneumonia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4100
# text = Chlamydia pneumoniae is an important respiratory pathogen.
1	Chlamydia	Chlamydia	PROPN	NNP	Number=Sing	_	_	_	_
2	pneumoniae	pneumoniae	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
7	pathogen	pathogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4101
# text = Recently, its presence has been demonstrated in atherosclerotic lesions.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4102
# text = In this study, we characterized C. pneumoniae-mediated activation of endothelial cells and demonstrated an enhanced expression of endothelial adhesion molecules followed by subsequent rolling, adhesion, and transmigration of leukocytes (monocytes, granulocytes).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
8	pneumoniae	pneumoniae	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
27	rolling	rolling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	transmigration	transmigration	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4103
# text = These effects were blocked by mAbs against endothelial and/or leukocyte adhesion molecules (beta1 and beta2 integrins).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
7	against	against	ADP	IN	_	_	_	_	_
8	endothelial	endothelial	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	or	or	CCONJ	CC	_	_	_	_	_
12	leukocyte	leukocyte	VERB	VB	VerbForm=Inf	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
19	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4104
# text = Additionally, activation of different signal transduction pathways in C. pneumoniae-infected endothelial cells was shown: protein tyrosine phosphorylation, up-regulation of phosphorylated p42/p44 mitogen-activated protein kinase, and NF-kappaB activation/translocation occurred within 10-15 min.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
11	pneumoniae	pneumonia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	p42	p42	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	p44	p44	NUM	CD	NumType=Card	_	_	_	_
31	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	-activated	-activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
42	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
43	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	within	within	ADP	IN	_	_	_	_	_
45	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	15	15	NUM	CD	NumType=Card	_	_	_	_
48	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4105
# text = Increased mRNA and surface expression of E-selectin, ICAM-1, and VCAM-1 were noted within hours.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4106
# text = Thus, C. pneumoniae triggers a cascade of events that could lead to endothelial activation, inflammation, and thrombosis, which in turn may result in or may promote atherosclerosis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
4	pneumoniae	pneumoniae	NOUN	NN	Number=Sing	_	_	_	_
5	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	thrombosis	thrombosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
31	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4107
# text = Document 003001291 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001291	003001291	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4108
# text = A functional T-cell receptor signaling pathway is required for p95vav activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4109
# text = Stimulation of the T-cell antigen receptor (TCR) induces activation of multiple tyrosine kinases, resulting in phosphorylation of numerous intracellular substrates.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4110
# text = One substrate is p95vav, which is expressed exclusively in hematopoietic and trophoblast cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	exclusively	exclusively	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	trophoblast	trophoblast	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4111
# text = It contains a number of structural motifs, including Src homology 2, Src homology 3, and pleckstrin homology domains and a putative guanine nucleotide exchange domain.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	number	number	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
11	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
15	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	pleckstrin	pleckstrin	ADJ	JJ	Degree=Pos	_	_	_	_
20	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
25	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
26	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
27	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
28	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4112
# text = The role of p95vav in TCR-mediated signaling processes is unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4113
# text = Here, we show that overexpression of p95vav alone in Jurkat T cells leads to activation of the nuclear factors, including NFAT, involved in interleukin-2 expression.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
9	alone	alone	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4114
# text = Furthermore, p95vav synergizes with TCR stimulation in inducing NFAT- and interleukin-2-dependent transcription.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p95vav	p95vave	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	synergizes	synergize	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4115
# text = In contrast, NFAT activation by a G-protein-coupled receptor is not modulated by p95vav overexpression, suggesting that the effect is specific to the TCR signaling pathways.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
17	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4116
# text = Although removal of the first 67 amino acids of p95vav activates its transforming potential in NIH 3T3 cells, this region appears to be required for its function in T cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	67	67	NUM	CD	NumType=Card	_	_	_	_
7	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
8	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
11	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
14	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	NIH	Nih	PROPN	NNP	Number=Sing	_	_	_	_
17	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4117
# text = We further demonstrate that the p95vav-induced NFAT activation is not mimicked by Ras activation, though its function is dependent upon Ras and Raf.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	though	though	SCONJ	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	upon	upon	ADP	IN	_	_	_	_	_
24	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4118
# text = Furthermore, the activating function of p95vav is blocked by FK506, suggesting that its activity also depends on calcineurin.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p95vav	p95vav	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4119
# text = To further dissect p95vav involvement in TCR signaling, we analyzed various Jurkat mutants deficient in TCR signaling function or TCR expression and showed that an intact TCR signaling pathway is required for p95vav to function.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	dissect	dissect	NOUN	NN	Number=Sing	_	_	_	_
4	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
15	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
28	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
29	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	function	function	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4120
# text = However, overexpression of p95vav does not appear to influence TCR-induced protein tyrosine phosphorylation or increases in cytoplasmic free calcium.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p95vav	p95vav	NOUN	NN	Number=Sing	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
11	TCR	Tcr	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
21	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
22	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4121
# text = Taken together, our data suggest that p95vav plays an important role at an yet unidentified proximal position in the TCR signaling cascade.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	yet	yet	ADV	RB	_	_	_	_	_
16	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	position	position	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
23	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4122
# text = Document 003001292 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001292	003001292	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4123
# text = Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
1	Separation	separation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	redox	redox	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4124
# text = Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	begins	begin	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
17	series	series	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stimuli-specific	stimuli-specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
34	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	mitomycin	mitomycin	NOUN	NN	Number=Sing	_	_	_	_
37	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
42	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
45	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
47	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
48	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
50	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	individually	individually	ADV	RB	_	_	_	_	_
53	initiate	initiate	ADJ	JJ	Degree=Pos	_	_	_	_
54	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4125
# text = These initial pathways culminate in a common pathway through which all of the stimulating agents ultimately signal NF-kappa B activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	culminate	culminate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
16	ultimately	ultimately	ADV	RB	_	_	_	_	_
17	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4126
# text = We distinguish the stimuli-specific pathways by showing that the oxidative stimuli trigger NF-kappa B activation in only one of two human T-cell lines (Wurzburg but not Jurkat), whereas tumor necrosis factor alpha and phorbol 12-myristate 13-acetate readily stimulate in both lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	distinguish	distinguish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	stimuli-specific	stimuli-specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
12	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	whereas	whereas	SCONJ	IN	_	_	_	_	_
35	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
36	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
41	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
43	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
44	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
47	readily	readily	ADV	RB	_	_	_	_	_
48	stimulate	stimulate	ADV	RB	Degree=Pos	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	both	both	DET	DT	_	_	_	_	_
51	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4127
# text = We propose the common pathway as the simplest way of accounting for the common requirements and properties of the signaling pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	simplest	simplest	ADJ	JJS	Degree=Sup	_	_	_	_
9	way	way	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	accounting	accounte	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
15	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4128
# text = We include a redox-regulatory mechanism(s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don't activate NF-kappa B); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47) is required for NF-kappa B activation by all stimuli tested in both cell lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	redox	redox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s	s	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	previously	previously	ADV	RB	_	_	_	_	_
20	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	in	in	ADP	IN	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
36	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
37	n't	not	PART	RB	_	_	_	_	_
38	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
39	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	;	;	PUNCT	,	_	_	_	_	_
45	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
46	put	put	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
48	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
52	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
53	by	by	SCONJ	IN	_	_	_	_	_
54	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
55	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
60	by	by	ADP	IN	_	_	_	_	_
61	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
62	A	a	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	tyrphostin	tyrphostin	NOUN	NN	Number=Sing	_	_	_	_
65	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	)	)	PUNCT	-RRB-	_	_	_	_	_
67	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
68	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
69	for	for	ADP	IN	_	_	_	_	_
70	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
72	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
73	B	b	NOUN	NN	Number=Sing	_	_	_	_
74	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
75	by	by	ADP	IN	_	_	_	_	_
76	all	all	DET	DT	_	_	_	_	_
77	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
78	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
79	in	in	ADP	IN	_	_	_	_	_
80	both	both	DET	DT	_	_	_	_	_
81	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
82	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4129
# text = Since internal sites of oxidant production have been shown to play a key role in the cytokine-stimulated activation of NF-kappa B, and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway.
1	Since	since	ADP	IN	_	_	_	_	_
2	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	since	since	SCONJ	IN	_	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
33	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
44	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	that	that	SCONJ	IN	_	_	_	_	_
46	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
47	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
48	status	status	NOUN	NN	Number=Sing	_	_	_	_
49	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
50	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
53	B	b	NOUN	NN	Number=Sing	_	_	_	_
54	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
55	by	by	SCONJ	IN	_	_	_	_	_
56	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
57	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
58	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
59	event	event	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	s	s	X	AFX	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	within	within	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
66	step	step	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
72	B	b	NOUN	NN	Number=Sing	_	_	_	_
73	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
74	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
75	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4130
# text = Document 003001293 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001293	003001293	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4131
# text = CD30 ligation induces nuclear factor-kappa B activation in human T cell lines.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4132
# text = CD30 is a recently described member of the tumor necrosis factor/nerve growth factor receptor superfamily.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	member	member	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	nerve	nerve	NOUN	NN	Number=Sing	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4133
# text = In this report, we show that following incubation of L540 cells (Hodgkin's disease-derived, T cell-like, CD30+ cells) with the agonistic anti-CD30 monoclonal antibodies (mAb) M44 and M67, two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts, as determined in gel retardation assays.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	L540	L540	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	like	like	INTJ	UH	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	agonistic	agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
32	anti-CD30	anti-CD30	NUM	CD	NumType=Card	_	_	_	_
33	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
34	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	M44	m44	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	M67	M67	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	two	two	NUM	CD	NumType=Card	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
50	B	b	NOUN	NN	Number=Sing	_	_	_	_
51	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
52	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
53	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
54	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
58	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	as	as	SCONJ	IN	_	_	_	_	_
61	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
64	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
65	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4134
# text = The effect of the mAb towards NF-kappa B activation was rapid, as it occurred within 20 min, and was sustained for up to 6 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
6	towards	towards	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	20	20	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	up	up	ADV	RB	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4135
# text = By comparison, an isotype-matched antibody had no effect on NF-kappa B activation.
1	By	by	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	isotype-matched	isotype-matched	ADJ	JJ	Degree=Pos	_	_	_	_
6	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4136
# text = Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30-mediated NF-kappa B activation correlated with the proportion of CD30+ cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Th	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
11	functionally	functionally	ADV	RB	_	_	_	_	_
12	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	28	28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	<	<	PUNCT	-LRB-	_	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	_
32	und	und	ADJ	JJ	Degree=Pos	_	_	_	_
33	93	93	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	%	%	SYM	NN	Number=Sing	_	_	_	_
35	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
50	B	b	NOUN	NN	Number=Sing	_	_	_	_
51	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
52	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	+	+	SYM	SYM	_	_	_	_	_
59	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4137
# text = In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1, p65 RelA, and possibly other transcription factors.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
16	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
21	p50	p50	NUM	CD	NumType=Card	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B1	b1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	possibly	possibly	ADV	RB	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4138
# text = Collectively, our results demonstrate that nuclear translocation and activation of NF-kappa B rank among the short-term cellular responses elicited following CD30 ligation.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	rank	rank	NOUN	NN	Number=Sing	_	_	_	_
17	among	among	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	term	term	NOUN	NN	Number=Sing	_	_	_	_
22	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
23	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
24	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
27	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4139
# text = Document 003001294 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001294	003001294	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4140
# text = Downregulation of Wilms' tumor gene (WT1) is not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562.
1	Downregulation	Downregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Wilms	Wilm	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
4	'	's	PART	POS	_	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WT1	WT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	K562	k562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4141
# text = The Wilms' tumor gene (WT1) encodes a transcription factor of the zinc finger type.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Wilms	Wilm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	'	's	PART	POS	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	WT1	wt1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
16	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4142
# text = A high expression of WT1 has been detected in a range of acute leukemias, and WT1 is downregulated during induced differentiation of some leukemic cell lines.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	range	range	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	some	some	DET	DT	_	_	_	_	_
25	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4143
# text = Overexpression of WT1 in some myeloid cell lines confers resistance to differentiation induction.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	some	some	DET	DT	_	_	_	_	_
6	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
10	resistance	resistance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4144
# text = These observations suggest that a high WT1 expression in hematopoietic cells is incompatible with differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	WT1	wt1	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	incompatible	incompatible	ADJ	JJ	Degree=Pos	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4145
# text = In this study, each of the four different isoforms of WT1 was constitutively overexpressed in the leukemic cell line K562.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	each	each	DET	DT	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	four	four	NUM	CD	NumType=Card	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	constitutively	constitutively	ADV	RB	_	_	_	_	_
15	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	K562	K562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4146
# text = K562 cells express endogenous WT1, which is downregulated as a response to induced differentiation along the erythroid and megakaryocytic pathways.
1	K562	K562	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	WT1	wt1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4147
# text = We now demonstrate that a forced exogenous expression of the four different isoforms of WT1 in K562 does not affect the differentiation response, as judged by accumulation of hemoglobin in response to hemin or the expression of megakaryocytic cell surface markers in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	forced	force	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	four	four	NUM	CD	NumType=Card	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	K562	K562	NUM	CD	NumType=Card	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	hemin	hemin	VERB	VB	VerbForm=Inf	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
42	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	response	response	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	12-O-	12-O-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4148
# text = We conclude that downregulation of WT1 during induced differentiation of K562 cells is not a prerequisite for erythroid or megakaryocytic differentiation of these cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	WT1	WT1	NUM	CD	NumType=Card	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	K562	K562	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4149
# text = Document 003001295 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001295	003001295	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4150
# text = A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4151
# text = Interleukin-3 (IL-3) is a cytokine that is expressed primarily in activated T cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	primarily	primarily	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4152
# text = Here we identified an inducible T cell-specific enhancer 14 kb upstream of the IL-3 gene that responded to activation of T cell receptor signaling pathways.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	14	14	NUM	CD	NumType=Card	_	_	_	_
12	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
13	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4153
# text = The IL-3 enhancer spanned an inducible cyclosporin A-sensitive DNase I-hypersensitive site found only in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	spanned	span	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
10	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4154
# text = Four NFAT-like elements exist within the enhancer.
1	Four	Four	PROPN	NNP	Number=Sing	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	like	like	SCONJ	IN	_	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4155
# text = The two most active NFAT-like elements were located at the center of the DNase I-hypersensitive site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	most	most	ADV	RBS	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	like	like	SCONJ	IN	_	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	center	center	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4156
# text = One of these NFAT-like elements encompassed overlapping Oct- and NFATp/c-binding sites, which functioned in a highly synergistic manner.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	like	like	SCONJ	IN	_	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	encompassed	encompass	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NFATp/c	NFATp/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-binding	-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	functioned	function	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	highly	highly	ADV	RB	_	_	_	_	_
22	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4157
# text = We suggest that the T cell-specific expression of the IL-3 gene is partly controlled through the enhancer by cooperation between Oct and NFAT family proteins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	partly	partly	ADV	RB	_	_	_	_	_
18	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4158
# text = Document 003001296 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001296	003001296	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4159
# text = Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	stabilizes	stabilize	NOUN	NNS	Number=Plur	_	_	_	_
5	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4160
# text = Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-10	-10	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	lethal	lethal	ADJ	JJ	Degree=Pos	_	_	_	_
12	endotoxemia	endotoxemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4161
# text = This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
19	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4162
# text = Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-kappaB	-kappaB	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4163
# text = NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
18	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
21	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IkappaB-	Ikappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4164
# text = We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	resultant	resultant	NOUN	NN	Number=Sing	_	_	_	_
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IkappaB-	Ikappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4165
# text = The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4166
# text = Monocytes were isolated from human donors.
1	Monocytes	Monocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4167
# text = Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	100	100	NUM	CD	NumType=Card	_	_	_	_
10	ng/	ng/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
11	mL	mL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	IL-10	IL-10	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4168
# text = Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
21	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
22	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
23	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
32	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4169
# text = We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	798+/-67	798+/-67	NUM	CD	NumType=Card	_	_	_	_
17	pg/mL	pg/mL	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	p	p	NOUN	NN	Number=Sing	_	_	_	_
20	<	<	PUNCT	-LRB-	_	_	_	_	_
21	.001	.001	NUM	CD	NumType=Card	_	_	_	_
22	versus	versus	ADJ	JJ	Degree=Pos	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4170
# text = IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	297+/-54	297+/-54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	p	p	NOUN	NN	Number=Sing	_	_	_	_
16	<	<	PUNCT	-LRB-	_	_	_	_	_
17	.001	.001	NUM	CD	NumType=Card	_	_	_	_
18	versus	versus	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
20	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4171
# text = After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
1	After	after	ADP	IN	_	_	_	_	_
2	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4172
# text = IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
5	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4173
# text = IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	preserving	preserve	VERB	VBG	VerbForm=Ger	_	_	_	_
14	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	alpha	alpha	ADP	IN	_	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4174
# text = Document 003001297 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001297	003001297	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4175
# text = Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
3	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	markedly	markedly	ADV	RB	_	_	_	_	_
6	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4176
# text = Although many functions of human alveolar macrophages are altered compared with their precursor cell, the blood monocyte (monocyte), the reason(s) for these functional changes have not been determined.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	reason	reason	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	s	s	X	AFX	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
31	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
32	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	determined	determin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4177
# text = We recently reported that human alveolar macrophages do not express AP-1 DNA binding activity (Monick, M. M., Carter, A. B., Gudmundsson, G., Geist, L. J., and Hunninghake, G. W. (1998)
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Monick	Monick	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
21	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Carter	Carter	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	A.	A.	PROPN	NNP	Number=Sing	_	_	_	_
26	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Gudmundsson	Gudmundsson	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	G.	G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	Geist	Geist	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
35	J.	J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	Hunninghake	Hunninghake	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
41	W.	W.	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	1998	1998	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 4178
# text = Am.
1	Am	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4179
# text = J. Physiol. 275, L389-L397).
1	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
2	Physiol	Physiol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_
4	275	275	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	L389-	l389-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	L397	L397	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4180
# text = To determine why alveolar macrophages do not express AP-1 DNA binding activity, we first showed that there was not a decrease in expression of the FOS and JUN proteins that make up the AP-1 complex.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	why	why	ADV	WRB	PronType=Int	_	_	_	_
4	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
5	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
6	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	first	first	ADV	RB	_	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	there	there	PRON	EX	_	_	_	_	_
21	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	FOS	Fo	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	JUN	Jun	ADJ	JJ	Degree=Pos	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	up	up	ADP	RP	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4181
# text = There was, however, a significant difference in the amounts of the nuclear protein, REF-1 (which regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins), in alveolar macrophages compared with monocytes.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
8	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	by	by	SCONJ	IN	_	_	_	_	_
29	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
32	status	status	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	JUN	JUN	PROPN	NNP	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
42	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
43	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4182
# text = In addition, in vitro differentiation of monocytes to a macrophage-like cell resulted in decreased amounts of REF-1.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4183
# text = Finally, addition of REF-1 from activated monocytes to alveolar macrophage nuclear proteins resulted in a marked increase in AP-1 DNA binding.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	alveolar	alveolar	VERB	VB	VerbForm=Inf	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4184
# text = These studies strongly suggest that the process of differentiation of monocytes into alveolar macrophages is associated with a loss of REF-1 and AP-1 activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	process	process	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4185
# text = This observation may explain, in part, some of the functional differences observed for alveolar macrophages compared with monocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4186
# text = Document 003001298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001298	003001298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4187
# text = Induction of immediate early response genes by macrophage colony-stimulating factor in normal human monocytes.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
4	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4188
# text = A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes have been termed immediate early response genes, and their induction has been associated with growth factor-stimulated cell proliferation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	group	group	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	coordinately	coordinately	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	protooncogenes	protooncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	cytoskeletal	cytoskeletal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
18	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4189
# text = We have investigated the induction of these genes by macrophage-CSF (M-CSF) in human monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4190
# text = Normal human monocytes were isolated, carefully washed, and incubated for 36 to 48 h in fetal bovine serum-containing medium.
1	Normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	carefully	carefully	ADV	RB	_	_	_	_	_
8	washed	wash	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	36	36	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	48	48	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
19	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
20	serum-	serum-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4191
# text = At the end of this incubation the resting cells were stimulated with M-CSF, and RNA was isolated for analysis by Northern blotting.
1	At	at	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	end	end	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	resting	resting	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
25	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4192
# text = RNA from control resting cells contained low to undetectable levels of c-jun, fibronectin receptor, and actin mRNA.
1	RNA	RNa	ADP	IN	_	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	control	control	NOUN	NN	Number=Sing	_	_	_	_
4	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	low	low	ADV	RB	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	actin	actin	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4193
# text = Within 15 to 30 min of addition of M-CSF, however, there was a dramatic coordinate induction of these genes.
1	Within	within	ADP	IN	_	_	_	_	_
2	15	15	NUM	CD	NumType=Card	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	30	30	NUM	CD	NumType=Card	_	_	_	_
5	min	min	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	there	there	PRON	EX	_	_	_	_	_
16	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
19	coordinate	coordinate	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4194
# text = The c-jun gene expression was very transient and was not detectable by 60 min after M-CSF addition.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	60	60	NUM	CD	NumType=Card	_	_	_	_
15	min	min	NOUN	NNS	Number=Plur	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4195
# text = In contrast, the expression of actin and fibronectin receptor mRNA was more sustained, and the expression of these genes remained elevated at 24 to 48 h after M-CSF addition.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	actin	actin	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	more	more	ADV	RBR	_	_	_	_	_
14	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	24	24	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	48	48	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
32	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4196
# text = We also observed the induction of the myelomonocytic specific tyrosine kinase hck gene simultaneously with the other immediate early response genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	hck	hck	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4197
# text = The protein synthesis inhibitor cycloheximide did not block the induction of any of these genes, and in fact, super-induced the expression of c-jun and hck.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
5	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	any	any	DET	DT	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	super	super	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	hck	hck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4198
# text = Nuclear run on transcription of the c-jun, hck, and actin genes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	hck	hck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	actin	actin	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4199
# text = Therefore, in normal human monocytes M-CSF induces immediate early response genes without inducing cell proliferation.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	without	without	SCONJ	IN	_	_	_	_	_
16	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4200
# text = These genes may then play a role in altering the physiologic status of the cells in response to CSF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
12	status	status	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4201
# text = Document 003001299 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001299	003001299	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4202
# text = Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.
1	Cloning	Cloning	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	myeloid-cell	myeloid-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4203
# text = Chicken NF-M transcription factor, in cooperation with either c-Myb or v-Myb, is active in the combinatorial activation of myeloid-cell-specific genes in heterologous cell types, such as embryonic fibroblasts.
1	Chicken	Chicken	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	M	M	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	combinatorial	combinatorial	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	myeloid-cell	myeloid-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
38	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4204
# text = In humans, similar effects were observed with homologous members of the CCAAT/enhancer-binding protein (C/EBP) family of transcriptional regulators, especially the human homolog of chicken NF-M, C/EBP-beta (NF-IL6).
1	In	in	ADP	IN	_	_	_	_	_
2	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	especially	especially	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	chicken	chicken	NOUN	NN	Number=Sing	_	_	_	_
34	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	C/EBP-	C/EBP-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4205
# text = However, the NF-IL6 gene is expressed in a variety of nonmyeloid cell types and is strongly inducible in response to inflammatory stimuli, making it an unlikely candidate to have an exclusive role as a combinatorial differentiation switch during myelopoiesis in human cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	strongly	strongly	ADV	RB	_	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
28	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	unlikely	unlikely	ADJ	JJ	Degree=Pos	_	_	_	_
31	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	combinatorial	combinatorial	ADJ	JJ	Degree=Pos	_	_	_	_
40	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
41	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
42	during	during	ADP	IN	_	_	_	_	_
43	myelopoiesis	myelopoiesis	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4206
# text = By using a reverse transcription-PCR-based approach and a set of primers specific for the DNA-binding domains of highly homologous members of the C/EBP family of transcriptional regulators, we have cloned a novel human gene encoding a member of the C/EBP gene family, identified as the human homolog of CRP1, C/EBP-epsilon.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	set	set	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	primers	primer	NOUN	NNS	Number=Plur	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	highly	highly	ADV	RB	_	_	_	_	_
25	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	member	member	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
51	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
52	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
53	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	as	as	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
59	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	CRP1	CRP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4207
# text = A 1.2-kb cDNA encoding full-length human C/EBP-epsilon was cloned from a promyelocyte-late myeloblast-derived lambda gt11 library.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	1.2	1.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	length	length	NOUN	NN	Number=Sing	_	_	_	_
10	human	human	NOUN	NN	Number=Sing	_	_	_	_
11	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	EBP-	EBP-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
22	myeloblast	myeloblast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
26	gt11	gt11	NUM	CD	NumType=Card	_	_	_	_
27	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4208
# text = Molecular analysis of the cDNA and genomic clones indicated the presence of two exons encoding a protein with an apparent molecular mass of 32 kDa and a pI of 9.5.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cDNA	cDNa	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
15	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	32	32	NUM	CD	NumType=Card	_	_	_	_
25	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	pI	pi	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	9.5	9.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4209
# text = Primer extension analysis of C/EBP-epsilon mRNA detected a single major transcription start site approximately 200 bp upstream of the start codon.
1	Primer	Primer	NOUN	NN	Number=Sing	_	_	_	_
2	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	start	start	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	approximately	approximately	ADV	RB	_	_	_	_	_
19	200	200	NUM	CD	NumType=Card	_	_	_	_
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	start	start	NOUN	NN	Number=Sing	_	_	_	_
25	codon	codon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4210
# text = The putative promoter area is similar to those of several other myeloid-cell-specific genes in that it contains no TATAAA box but has a number of purine-rich stretches with multiple sites for the factors of the Ets family of transcriptional regulators.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	area	area	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	no	no	DET	DT	_	_	_	_	_
23	TATAAA	TATAAa	NOUN	NN	Number=Sing	_	_	_	_
24	box	box	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	number	number	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
33	stretches	stretch	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
43	family	family	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
46	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4211
# text = Northern blot analyses indicated a highly restricted mRNA expression pattern, with the strongest expression occurring in promyelocyte and late-myeloblast-like cell lines.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	strongest	strongest	ADJ	JJS	Degree=Sup	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	myeloblast	myeloblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4212
# text = Western blot and immunoprecipitation studies using rabbit anti-C/EBP-epsilon antibodies raised against the N-terminal portion of C/EBP-epsilon (amino acids 1 to 115) showed that C/EBP-epsilon is a 32-kDa nuclear phosphoprotein.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
8	anti-C	anti-c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	against	against	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	amino	amino	DET	DT	_	_	_	_	_
28	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	115	115	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	EBP-	EBP-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
44	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
45	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4213
# text = The human C/EBP-epsilon protein exhibited strong and specific binding to double-stranded DNA containing consensus C/EBP sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stranded	stranded	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
21	C/	C/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4214
# text = Cotransfection of the C/EBP-epsilon sense and antisense expression constructs together with chloramphenicol acetyltransferase reporter vectors containing myeloid-cell-specific c-mim and human myeloperoxidase promoters suggested a role for C/EBP-epsilon transcription factor in the regulation of a subset of myeloid-cell-specific genes.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
9	sense	sense	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
14	together	together	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
17	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	myeloid-cell	myeloid-cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	c-mim	c-mim	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	_
28	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
29	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
52	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4215
# text = Transient tranfection of a promyelocyte cell line (NB4) with a C/EBP-epsilon expression plasmid increased cell growth by sevenfold, while antisense C/EBP-epsilon caused a fivefold decrease in clonal growth of these cells.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	tranfection	tranfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NB4	NB4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	X	FW	Foreign=Yes	_	_	_	_
18	expression	expression	X	GW	_	_	_	_	_
19	plasmid	plasmid	X	AFX	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	sevenfold	sevenfold	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
28	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	EBP-	EBP-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
32	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	fivefold	fivefold	ADJ	JJ	Degree=Pos	_	_	_	_
35	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
38	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4216
# text = Document 003001300 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001300	003001300	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4217
# text = Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Ets-	Ets-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4218
# text = The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
16	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4219
# text = Elf-1 is a lymphoid-specific Ets transcription factor that regulates inducible gene expression during T cell activation.
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4220
# text = In this report, it is demonstrated that Elf-1 contains a sequence motif that is highly related to the Rb binding sites of several viral oncoproteins and binds to the pocket region of Rb both in vitro and in vivo.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	highly	highly	ADV	RB	_	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Rb	Rb	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	pocket	pocket	NOUN	NN	Number=Sing	_	_	_	_
34	region	region	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
37	both	both	CCONJ	CC	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4221
# text = Elf-1 binds exclusively to the underphosphorylated form of Rb and fails to bind to Rb mutants derived from patients with retinoblastoma.
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
5	exclusively	exclusively	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	underphosphorylated	underphosphorylated	ADJ	JJ	Degree=Pos	_	_	_	_
9	form	form	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
18	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4222
# text = Co-immunoprecipitation experiments demonstrated an association between Elf-1 and Rb in resting normal human T cells.
1	Co	co	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-immunoprecipitation	-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4223
# text = After T cell activation, the phosphorylation of Rb results in the release of Elf-1, which is correlated temporally with the activation of Elf-1-mediated transcription.
1	After	after	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	temporally	temporally	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4224
# text = Overexpression of a phosphorylation-defective form of Rb inhibited Elf-1-dependent transcription during T cell activation.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4225
# text = These results demonstrate that Rb interacts specifically with a lineage-restricted Ets transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4226
# text = This regulated interaction may be important for the coordination of lineage-specific effector functions such as lymphokine production with cell cycle progression in activated T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	regulated	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
3	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	lymphokine	lymphokine	ADJ	JJ	Degree=Pos	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
23	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4227
# text = Document 003001301 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001301	003001301	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4228
# text = Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	8	8	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	through	through	SCONJ	IN	_	_	_	_	_
20	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
21	concurrently	concurrently	ADV	RB	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	kappaB-	kappaB-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	8	8	NUM	CD	NumType=Card	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4229
# text = Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	8	8	NUM	CD	NumType=Card	_	_	_	_
34	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4230
# text = The functional analysis of the IL-8 gene revealed that both AP-1- and NF-kappaB factor-binding elements were involved in conferring the responsiveness to CMV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	8	8	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	SCONJ	IN	_	_	_	_	_
28	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4231
# text = Moreover, electrophoretic mobility shift assays demonstrated that CMV induced the formation of NF-kappaB and AP-1 complexes.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4232
# text = These results suggest that CMV activates these transcriptional factors, resulting in IL-8 gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4233
# text = Document 003001302 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001302	003001302	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4234
# text = The NF kappa B independent cis-acting sequences in HIV-1 LTR responsive to T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	B	PROPN	NNP	Number=Sing	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	T-	t-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4235
# text = The rate of transcription initiation directed by the long terminal repeat (LTR) of HIV-1 increases in response to mitogenic stimuli of T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4236
# text = Here we show that the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	governed	govern	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4237
# text = The rate of LTR-directed gene expression increased in response to treatment with either a phorbol ester or tumor necrosis factor alpha if either the NFAT-1 or NF kappa B binding sites were deleted, but failed to respond to these mitogenic stimuli if both sequences were absent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	treatment	treatment	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	if	if	SCONJ	IN	_	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	failed	fail	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
46	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
47	if	if	SCONJ	IN	_	_	_	_	_
48	both	both	DET	DT	_	_	_	_	_
49	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
50	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4238
# text = The HIV-1 mutant virus containing both NF kappa B and NFAT-1 deletion was able to replicate although at a much decreased growth rate, while the deletion of NFAT-1 alone increased the viral growth rate in Jurkat cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
21	although	although	SCONJ	IN	_	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
25	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	alone	alone	ADV	RB	_	_	_	_	_
37	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
41	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4239
# text = Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester.
1	Neither	neither	DET	DT	_	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	ADJ	JJ	Degree=Pos	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4240
# text = Document 003001303 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001303	003001303	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4241
# text = Control of NF-kappa B activity by the I kappa B beta inhibitor.
1	Control	Control	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4242
# text = The transcription factor NF-kappa B is maintained in an inactive cytoplasmic state by I kappa B inhibitors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	state	state	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4243
# text = In mammalian cells, I kappa B alpha and I kappa B beta proteins have been purified and shown to be the inhibitors of NF-kappa B through their association with the p65 or c-Rel subunits.
1	In	in	ADP	IN	_	_	_	_	_
2	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	association	association	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
39	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4244
# text = In addition, we have isolated a third NF-kappa B inhibitor, I kappa B epsilon (1).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4245
# text = Upon treatment with a large variety of inducers, I kappa B alpha, I kappa B beta are proteolytically degraded, resulting in NF-kappa B translocation into the nucleus.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
6	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	proteolytically	proteolytically	ADV	RB	_	_	_	_	_
21	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4246
# text = Here we show that in E29.1
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	E29.1	E29.1	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4247
# text = T cell hybridoma
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4248
# text = I kappa B alpha and I kappa B beta are equally associated with p65 and that I kappa B beta is degraded in response to TNF alpha in contrast to what has been originally published.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	b	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	equally	equally	ADV	RB	_	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	SCONJ	IN	_	_	_	_	_
31	what	what	PRON	WP	PronType=Int	_	_	_	_
32	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	originally	originally	ADV	RB	_	_	_	_	_
35	published	publish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4249
# text = Our data also suggest that, unlike I kappa B alpha, I kappa B beta is constitutively phosphorylated and resynthesized as a hypophosphorylated form.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	unlike	unlike	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	constitutively	constitutively	ADV	RB	_	_	_	_	_
19	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	resynthesized	resynthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	hypophosphorylated	hypophosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4250
# text = The absence of slow migrating forms of I kappa B beta following stimulation suggests that the phosphorylation does not necessarily constitute the signal-induced event which targets the molecule for proteolysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
5	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
6	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	necessarily	necessarily	ADV	RB	_	_	_	_	_
21	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	event	event	NOUN	NN	Number=Sing	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	targets	target	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	proteolysis.	proteolysis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4251
# text = Document 003001304 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001304	003001304	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4252
# text = Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4253
# text = NF-IL6 is an important transcriptional regulator of genes induced in activated monocytes/macrophages, and NF-IL6 is the only CCAAT/enhancer-binding protein (C/EBP) family member whose steady-state mRNA levels increase upon activation of monocytes (1).
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
25	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	member	member	NOUN	NN	Number=Sing	_	_	_	_
37	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
38	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	state	state	NOUN	NN	Number=Sing	_	_	_	_
41	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
42	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
43	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
44	upon	upon	ADP	IN	_	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4254
# text = We show that increased transcription of the NF-IL6 gene is responsible, at least in part, for induction of NF-IL6 mRNA following activation of U937 promonocytic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
26	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4255
# text = We have identified a 104-bp minimal promoter region of the NF-IL6 gene that is sufficient for basal and activation-dependent induction of transcription in U937 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	104	104	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4256
# text = This region contains binding sites for the cAMP response element-binding protein/activation transcription factor (CREB/ATF) and Sp1 families of transcription factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
25	families	family	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4257
# text = Each site is functionally important and contributes independently to transcription of the NF-IL6 gene in U937 cells.
1	Each	each	DET	DT	_	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	independently	independently	ADV	RB	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4258
# text = Document 003001305 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001305	003001305	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4259
# text = Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	MCF	Mcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	13	13	NUM	CD	NumType=Card	_	_	_	_
12	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	long	long	ADV	RB	Degree=Pos	_	_	_	_
16	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4260
# text = The region downstream of the enhancer (DEN) of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for viral pathogenicity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	DEN	DEN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mink	mink	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	focus	focus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
22	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathogenicity	pathogenicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4261
# text = Another important activity of DEN is its control of transcription in activated T cells, and we have determined that an NF-kappaB site is critical for this activity.
1	Another	another	DET	DT	_	_	_	_	_
2	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	DEN	DEN	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4262
# text = Document 003001306 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001306	003001306	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4263
# text = Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by NF-kappa B binding motifs.
1	Lymphoid	Lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	adenovirus	adenovirus	ADJ	JJ	Degree=Pos	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4264
# text = A primary site of infection by human adenoviruses is lymphoid cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	adenoviruses	adenoviruse	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4265
# text = However, analysis of the viral control elements and the cellular factors that regulate adenoviral gene expression in lymphocytes has not been reported.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4266
# text = The adenovirus early region 3 (ES) gene products are involved in the maintenance of viral persistence by complexing with the class I MHC antigens, thus preventing their cell surface expression with a resultant decrease in host immunologic destruction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adenovirus	adenovirus	ADJ	JJ	Degree=Pos	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ES	ES	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	products	product	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
18	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	complexing	complex	VERB	VBG	VerbForm=Ger	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
26	antigens	antigens	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	thus	thus	ADV	RB	_	_	_	_	_
29	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	resultant	resultant	ADJ	JJ	Degree=Pos	_	_	_	_
37	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	host	host	NOUN	NN	Number=Sing	_	_	_	_
40	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
41	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4267
# text = To determine whether different cellular factors were involved in E3 regulation in lymphocytes as compared with HeLa cells, both DNA binding and transfection analysis with the E3 promoter in both cell types were performed.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	E3	E3	NUM	CD	NumType=Card	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4268
# text = These studies detected two novel domains referred to as L1 and L2 with a variety of lymphoid but not HeLa extracts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
7	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	L1	L1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	L2	L2	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
21	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4269
# text = Each of these domains possessed strong homology to motifs previously found to bind the cellular factor NF-kappa B.
1	Each	each	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
5	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
7	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
10	previously	previously	ADV	RB	_	_	_	_	_
11	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4270
# text = Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif (L2) had minimal effects on promoter expression in HeLa cells, but resulted in dramatic decreases in expression by lymphoid cells.
1	Transfections	Transfection	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	E3	E3	NUM	CD	NumType=Card	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
9	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	L2	l2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
39	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4271
# text = In contrast, mutagenesis of proximal NF-kappa B motif (L1) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	L1	L1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	small	small	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	reproducible	reproducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	when	when	ADV	WRB	PronType=Int	_	_	_	_
45	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	L2	l2	NOUN	NN	Number=Sing	_	_	_	_
49	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4272
# text = Reversing the position and subsequent mutagenesis of the L1 and L2 domains indicated that the primary sequence of these motifs rather than their position in the E3 promoter was critical for regulating gene expression.
1	Reversing	Reverse	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	position	position	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	L1	L1	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	L2	L2	NUM	CD	NumType=Card	_	_	_	_
12	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	position	position	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	SCONJ	IN	_	_	_	_	_
32	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4273
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4274
# text = Document 003001307 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001307	003001307	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4275
# text = The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Megakaryocyte	Megakaryocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
4	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
12	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
17	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
27	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4276
# text = The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
4	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	collagen	collagen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4277
# text = Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
6	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
11	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	core	core	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
19	-30	-30	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	92	92	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	351	351	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	''	_	_	_	_	_
42	flank	flank	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4278
# text = We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	229	229	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	''	_	_	_	_	_
15	flank	flank	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
19	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	level	level	NOUN	NN	Number=Sing	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	features	feature	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4279
# text = Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
3	AP1	AP1	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	dyad	dyad	NOUN	NN	Number=Sing	_	_	_	_
8	symmetry	symmetry	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	enhancer	enhancer	ADJ	JJR	Degree=Cmp	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	members	member	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	fos/c	fos/c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-jun	-jun	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4280
# text = The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mitogen	mitogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
24	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4281
# text = Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
24	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
25	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4282
# text = We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin enhancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	alpha2	alpha2	NOUN	NN	Number=Sing	_	_	_	_
14	integrin	integrin	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
17	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
27	AP1	AP1	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	alpha2	alpha2	NOUN	NN	Number=Sing	_	_	_	_
33	integrin	integrin	ADP	IN	_	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4283
# text = Document 003001308 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001308	003001308	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4284
# text = The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	evolutionarily	evolutionarily	ADV	RB	Degree=Pos	_	_	_	_
3	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
10	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
11	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
12	S	's	PART	POS	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
25	ligand	ligand	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	via	via	ADP	IN	_	_	_	_	_
31	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	6	6	NUM	CD	NumType=Card	_	_	_	_
40	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4285
# text = Germline C gamma gene transcription is a crucial event in the process that leads to switch DNA recombination to IgG, but its regulation in the human is poorly understood.
1	Germline	Germline	PROPN	NNP	Number=Sing	_	_	_	_
2	C	C	PROPN	NNP	Number=Sing	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	event	event	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	process	process	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	switch	switch	VERB	VB	VerbForm=Inf	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	human	human	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	poorly	poorly	ADV	RB	_	_	_	_	_
30	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4286
# text = We took advantage of our monoclonal model of germinal center B cell differentiation, IgM+ IgD+ CL-01 cells, to define the role of the I gamma 3 evolutionarily conserved sequence (ECS) in the germline transcriptional activation of the human C gamma 3 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	took	take	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
10	center	center	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IgM	IgM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	IgD	IgD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	CL	CL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	01	01	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	I	I	PROPN	NNP	Number=Sing	_	_	_	_
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	evolutionarily	evolutionarily	ADV	RB	_	_	_	_	_
34	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	C	C	PROPN	NNP	Number=Sing	_	_	_	_
48	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
49	3	3	NUM	CD	NumType=Card	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4287
# text = The I gamma 3 ECS lies upstream of the major I gamma 3 transcription initiation site and displays more than 90% identity with the corresponding human I gamma 1, I gamma 2, and I gamma 4 regions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	_
6	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
27	human	human	AUX	MD	VerbForm=Fin	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
38	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
39	4	4	NUM	CD	NumType=Card	_	_	_	_
40	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4288
# text = Reporter luciferase gene vectors containing the human gamma 3 ECS were used to transfect CL-01 cells, which have been shown to undergo Smu-->S gamma 3 DNA recombination, upon engagement of CD40 by CD40 ligand (CD40L) and exposure to IL-4.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	ECS	Ec	PROPN	NNP	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transfect	transfect	VERB	VB	VerbForm=Inf	_	_	_	_
15	CL	Cl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	01	01	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	undergo	undergo	PROPN	NNP	Number=Sing	_	_	_	_
26	Smu	Smu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-->	-->	PUNCT	,	_	_	_	_	SpaceAfter=No
28	S	s	PROPN	NNP	Number=Sing	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	upon	upon	ADP	IN	_	_	_	_	_
35	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
40	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	CD40L	CD40L	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4289
# text = In these transfected CL-01 cells, CD40:CD40L engagement and exposure to IL-4 synergistically induced gamma 3 ECS-dependent luciferase reporter gene activation.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CL	CL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	01	01	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	CD40:CD40L	Cd40:cd40l	PROPN	NNP	Number=Sing	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	4	for	NUM	CD	NumType=Card	_	_	_	_
17	synergistically	synergistically	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4290
# text = Targeted mutational analysis demonstrated that a tandem NF-kappa B/Rel binding motif is critical for the gamma 3 ECS responsiveness to both CD40L and IL-4, while a STAT-6-binding site is additionally required for IL-4 inducibility.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	mutational	mutational	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	_
23	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	CD40L	CD40L	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	while	while	SCONJ	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	additionally	additionally	ADV	RB	_	_	_	_	_
42	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	4	4	NUM	CD	NumType=Card	_	_	_	_
47	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4291
# text = Electrophoretic mobility shift assays showed that p50/p65/c-Rel and STAT-6 are effectively induced by CD40L and IL-4, respectively, and bind to specific DNA motifs within the ECS.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	ADV	RB	_	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	p50/p65/c	p50/p65/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	effectively	effectively	ADV	RB	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	CD40L	Cd40l	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4292
# text = These partially overlapping CD40L and IL-4 responsive elements are functionally cooperative as the disruption of one of them prevents synergistic promoter activation.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	partially	partially	ADV	RB	_	_	_	_	_
3	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD40L	Cd40l	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	functionally	functionally	ADV	RB	_	_	_	_	_
13	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	one	one	NUM	CD	NumType=Card	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
22	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4293
# text = Thus, the gamma 3 ECS is an inducible promoter containing cis elements that critically mediate CD40L and IL-4-triggered transcriptional activation of the human C gamma 3 gene.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	critically	critically	ADV	RB	_	_	_	_	_
16	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	3	3	NUM	CD	NumType=Card	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4294
# text = Document 003001309 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001309	003001309	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4295
# text = Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	independently	independently	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4296
# text = BACKGROUND: IL-5 is fundamentally involved in eosinophilic inflammation.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	fundamentally	fundamentally	ADV	RB	_	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4297
# text = Control of IL-5 production may be effective for the management of allergic diseases.
1	Control	Control	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	management	management	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
15	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4298
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4299
# text = We aimed to find the transcriptional mechanisms that regulate the IL-5 gene to selectively control IL-5 synthesis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	aimed	aim	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	selectively	selectively	ADV	RB	_	_	_	_	_
17	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	5	5	NUM	CD	NumType=Card	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4300
# text = METHODS: Allergen-specific T-cell clones and T-cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the transcriptional regulation of the IL-5 gene was investigated with transient transfection and electrophoretic mobility shift analysis.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Allergen	Allergen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	5	5	NUM	CD	NumType=Card	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
39	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
42	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
43	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
44	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4301
# text = RESULTS: A human IL-5 promoter/enhancer-luciferase gene construct, pIL-5(-511)Luc, was transcribed on activation of IL-5-producing T-cell clones, but not IL-5-nonproducing clones.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	pIL	pil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	(-511	(-511	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	Luc	Luc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	nonproducing	nonproducing	VERB	VBG	VerbForm=Ger	_	_	_	_
44	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4302
# text = pIL-5(-511)Luc was transcribed by T-cell hybridomas derived from fusion between IL-5-producing T-cell clones and an IL-5 gene-nonexpressing T-cell line, but not by hybridomas derived from IL-5-nonproducing T-cell clones.
1	pIL	pil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(-511	(-511	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	Luc	Luc	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	hybridomas	hybridoma	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	nonexpressing	nonexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
41	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	from	from	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	nonproducing	nonproducing	NOUN	NN	Number=Sing	_	_	_	_
48	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4303
# text = IL-5 synthesis was not only induced by T-cell receptor stimulation but also by IL-2 receptor stimulation.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4304
# text = Binding of NF-AT, NF-kappaB, and AP-1 was induced by T-cell receptor (TcR) stimulation, although there was no significant upregulation of binding by IL-2 stimulation.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	although	although	SCONJ	IN	_	_	_	_	_
27	there	there	PRON	EX	_	_	_	_	_
28	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	no	no	DET	DT	_	_	_	_	_
30	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
31	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	SCONJ	IN	_	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4305
# text = CONCLUSION: IL-5 synthesis by human helper
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4306
# text = T cells is regulated at the transcriptional level.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4307
# text = A unique transcriptional mechanism distinct from those regulating the IL-2 or IL-4 genes seems to control the IL-5 gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4308
# text = Selective regulation of IL-5 gene transcription may be useful for treating eosinophlic inflammation.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	eosinophlic	eosinophlic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4309
# text = Document 003001310 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001310	003001310	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4310
# text = Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
12	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4311
# text = Previous studies have implicated a role for intracellular thiols in the activation of nuclear factor-kappaB and transcriptional regulation of endothelial cell adhesion molecules.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4312
# text = This study was designed to determine whether changes in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesivity and to define the molecular mechanism that underlies this GSSG/GSH-induced adhesion response.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GSH	GSH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
24	neutrophil	neutrophil	ADP	IN	_	_	_	_	_
25	adhesivity	adhesivity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
31	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	underlies	underly	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	GSSG/GSH	GSSG/GSh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4313
# text = Treatment of human umbilical vein endothelial cell (HUVEC) monolayers for 6 hours with 0.2 mmol/L diamide and 1 mmol/L buthionine sulfoximine (BSO) decreased GSH levels and increased the ratio of GSSG to GSH without cell toxicity.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
5	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HUVEC	HUVEC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
17	mmol/L	mmol/l	NOUN	NN	Number=Sing	_	_	_	_
18	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	mmol/L	mmol/l	NOUN	NN	Number=Sing	_	_	_	_
22	buthionine	buthionine	NUM	CD	NumType=Card	_	_	_	_
23	sulfoximine	sulfoximine	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	BSO	BSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	GSH	Gsh	ADJ	JJ	Degree=Pos	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	GSH	Gsh	VERB	VB	VerbForm=Inf	_	_	_	_
38	without	without	ADP	IN	_	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4314
# text = These redox changes are similar to those observed with anoxia/reoxygenation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anoxia	anoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4315
# text = Diamide plus BSO-induced thiol/disulfide imbalance was associated with a biphasic increase in neutrophil adhesion to HUVECs with peak responses observed at 15 minutes (phase 1) and 240 minutes (phase 2).
1	Diamide	Diamide	PROPN	NNP	Number=Sing	_	_	_	_
2	plus	plus	CCONJ	CC	_	_	_	_	_
3	BSO	Bso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
9	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
23	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
24	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	15	15	NUM	CD	NumType=Card	_	_	_	_
27	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	240	240	NUM	CD	NumType=Card	_	_	_	_
34	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4316
# text = N-Acetylcysteine treatment attenuated neutrophil adhesion in both phases, which indicated a role for GSH in the adhesion responses.
1	N	not	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Acetylcysteine	Acetylcysteine	ADJ	JJ	Degree=Pos	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	neutrophil	neutrophil	ADP	IN	_	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4317
# text = Interestingly, phase 1 adhesion was inversely correlated with GSH levels but not with the GSSG/GSH ratio, whereas phase 2 neutrophil adhesion was positively correlated with GSSG/GSH ratio but not with GSH levels.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inversely	inversely	ADV	RB	_	_	_	_	_
8	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	GSH	Gsh	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GSSG	Gssg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	GSH	Gsh	PROPN	NNP	Number=Sing	_	_	_	_
19	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	positively	positively	ADV	RB	_	_	_	_	_
28	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	GSH	Gsh	PROPN	NNP	Number=Sing	_	_	_	_
33	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	GSH	Gsh	DET	DT	_	_	_	_	_
38	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4318
# text = Intercellular adhesion molecule-1 and P-selectin-specific monoclonal antibodies attenuated the increased neutrophil adhesion during both phases, whereas an anti-E-selectin monoclonal antibody also attenuated the phase 2 response.
1	Intercellular	Intercelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	P-selectin-specific	P-selectin-specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	anti-E-	anti-E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4319
# text = Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides that contained nuclear factor-kappaB or activator protein-1 cognate DNA sequences significantly attenuated the phase 2 response, which implicated a role for de novo protein synthesis.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	_
4	D	d	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	with	with	SCONJ	IN	_	_	_	_	_
9	competing	compete	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ds	d	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	cognate	cognate	NOUN	NN	Number=Sing	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
27	significantly	significantly	ADV	RB	_	_	_	_	_
28	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	implicated	implicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	role	role	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	de	de	PROPN	NNP	Number=Sing	_	_	_	_
40	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
42	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4320
# text = Surface expression of intercellular adhesion molecule-1, P-selectin, and E-selectin on HUVECs correlated with the phase 1 and 2 neutrophil adhesion responses.
1	Surface	surface	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	P-selectin	P-selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
17	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4321
# text = This study demonstrates that changes in endothelial cell GSSG/GSH cause transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules, which leads to a 2-phase neutrophil-endothelial adhesion response.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	GSH	Gsh	ADJ	JJ	Degree=Pos	_	_	_	_
12	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
36	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
39	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4322
# text = Document 003001311 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001311	003001311	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4323
# text = Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	P	p	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	5'-CGAAAATTTCC	5'-cgaaaatttcc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	:	:	PUNCT	:	_	_	_	_	_
32	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4324
# text = The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
26	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
29	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
34	ionophore	ionophore	ADV	RB	_	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	A23187	A23187	X	LS	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4325
# text = T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	AT	AT	SCONJ	IN	_	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4326
# text = We examined whether NF(P), a nuclear factor specific for the P sequence, is related to NF-kappa B and NF-AT.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	P	P	NOUN	NN	Number=Sing	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4327
# text = NF-kappa B (P65 or P65/P50 heterodimer) bound to the P sequence in electrophoretic mobility shift assays (EMSA) and activated transcription through the P sequence when expression plasmids were cotransfected with P sequence-driven reporter plasmids in Jurkat T cells.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P65	P65	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	P65	P65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	P50	P50	NUM	CD	NumType=Card	_	_	_	_
11	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	P	p	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	P	P	NOUN	NN	Number=Sing	_	_	_	_
32	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
33	when	when	ADV	WRB	PronType=Int	_	_	_	_
34	expression	expression	NUM	CD	NumType=Card	_	_	_	_
35	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	P	p	NOUN	NN	Number=Sing	_	_	_	_
40	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
44	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
47	T	T	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4328
# text = In EMSAs, NF(P) binding was inhibited by the unlabeled NF-AT binding site but not by the unlabeled AP1 binding site and purified NF-AT contained an activity that bound to the P sequence.
1	In	in	ADP	IN	_	_	_	_	_
2	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
14	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	AT	at	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
24	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AT	at	ADV	RB	_	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	P	P	NOUN	NN	Number=Sing	_	_	_	_
40	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4329
# text = Both mobility shift and sequence specificity of NF-AT were similar to those of NF(P) and only a small amount of P65 was detected in NF(P) in crude nuclear extracts.
1	Both	both	DET	DT	_	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	AT	AT	PRON	WDT	PronType=Rel	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	P65	P65	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	crude	crude	ADJ	JJ	Degree=Pos	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4330
# text = These results indicate that the component(s) of NF-AT has the potential to reconstitute NF(P) whereas NF-kappa B alone cannot account for NF(P) in crude extracts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
30	not	not	PART	RB	_	_	_	_	_
31	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	crude	crude	ADJ	JJ	Degree=Pos	_	_	_	_
39	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4331
# text = Unlike NF-AT, NF(P) does not contain AP1 as its DNA binding component.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
13	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4332
# text = Document 003001312 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001312	003001312	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4333
# text = Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4334
# text = The present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression during monocytic differentiation of U-937 myeloid leukemia cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	937	937	NUM	CD	NumType=Card	_	_	_	_
29	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4335
# text = Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threonine protein kinase C, was associated with transcriptional activation of EGR-1 promoter-reporter constructs.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	937	937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
38	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4336
# text = The EGR-1 promoter contains six CC(A/T)6GG (CArG) motifs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	six	six	NUM	CD	NumType=Card	_	_	_	_
8	CC	cc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	A/T	A/T	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	6GG	6gg	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CArG	CArG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4337
# text = The two 5'-most distal CArG sequences conferred TPA inducibility.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	most	most	ADV	RBS	_	_	_	_	_
7	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
8	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4338
# text = In contrast, there was little effect of TPA on EGR-1 transcription in a TPA-resistant U-937 cell variant, designated TUR.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	there	there	PRON	EX	_	_	_	_	_
5	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
20	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	937	937	NUM	CD	NumType=Card	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	variant	variant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	TUR	Tur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4339
# text = Treatment of both U-937 and TUR cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases 1 and 2A, was associated with induction of monocytic differentiation and EGR-1 transcription through the 5'-most CArG element.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	937	937	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	TUR	Tur	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	through	through	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
44	CArG	Carg	NOUN	NN	Number=Sing	_	_	_	_
45	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4340
# text = Since these findings supported the involvement of serine/threonine protein phosphorylation in the regulation of EGR-1 expression, we studied activation of the 40S ribosomal protein S6 serine/threonine kinases, pp70S6K and pp90rsk.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
4	supported	support	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	S	s	NOUN	NN	Number=Sing	_	_	_	_
29	ribosomal	ribosomal	ADJ	JJ	Degree=Pos	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	S6	S6	NUM	CD	NumType=Card	_	_	_	_
32	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
35	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	pp70S6	pp70S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	K	k	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4341
# text = Although both kinases participate in regulating cell growth, there was no detectable activation of pp70S6K during TPA- or okadaic acid-induced monocytic differentiation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	there	there	PRON	EX	_	_	_	_	_
11	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	no	no	DET	DT	_	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	pp70S6	pp70S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	K	k	NUM	CD	NumType=Card	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4342
# text = Moreover, rapamycin, an inhibitor of pp70S6K activation, had no effect on induction of EGR-1 expression.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	pp70S6	pp70S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	K	k	NUM	CD	NumType=Card	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4343
# text = In contrast, analysis of pp90rsk activity by phosphorylation of a peptide derived from S6 protein demonstrated stimulation of this kinase in TPA-treated U-937, and not TUR, cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	S6	S6	NUM	CD	NumType=Card	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	TUR	Tur	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4344
# text = Okadaic acid treatment of both cell types was associated with activation of pp90rsk.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	types	type	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4345
# text = Document 003001313 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001313	003001313	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4346
# text = Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.
1	Pyrrolidine	Pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
2	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
21	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	60	60	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4347
# text = We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	potently	potently	ADV	RB	_	_	_	_	_
14	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4348
# text = Treatment of a human promyelocytic leukemia cell line, HL-60, with 10 micrograms/mL etoposide or 2 microM 1-beta-D-arabinofuranosylcytosine induced NF-kappa B activation within 1 hr and subsequently caused apoptosis within 3-4 hr.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	micrograms	microgram	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	mL	mL	ADJ	JJ	Degree=Pos	_	_	_	_
19	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
23	1-beta	1-beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	D-	D-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	arabinofuranosylcytosine	arabinofuranosylcytosine	NOUN	NN	Number=Sing	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	subsequently	subsequently	ADV	RB	_	_	_	_	_
38	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	within	within	ADP	IN	_	_	_	_	_
41	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	4	4	NUM	CD	NumType=Card	_	_	_	_
44	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4349
# text = The simultaneous addition of 50-500 microM PDTC with these agents blocked NF-kappa B activation and completely abrogated both morphologically apoptotic changes and internucleosomal DNA fragmentation for up to 6 hr.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	500	500	NUM	CD	NumType=Card	_	_	_	_
8	microM	microm	NUM	CD	NumType=Card	_	_	_	_
9	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	completely	completely	ADV	RB	_	_	_	_	_
21	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	morphologically	morphologically	ADV	RB	_	_	_	_	_
24	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	internucleosomal	internucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	up	up	ADV	RB	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	6	6	NUM	CD	NumType=Card	_	_	_	_
34	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4350
# text = However, PDTC failed to inhibit the endonuclease activity contained in the whole cell lysates.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
4	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	endonuclease	endonuclease	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4351
# text = The inhibitory effect of PDTC was also observed in etoposide- and dexamethasone-induced apoptosis in human thymocytes at a concentration of 1-10 microM.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4352
# text = Since PDTC has both antioxidant and metal-ion chelating activities, we tested the effects of N-acetyl-L-cysteine (NAC) (antioxidant) or o-phenanthroline (OP) (metal-ion chelator) on the induction of apoptosis.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	metal	metal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	ion	ion	NOUN	NN	Number=Sing	_	_	_	_
10	chelating	chelating	NOUN	NN	Number=Sing	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-L	-l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	o-phenanthroline	o-phenanthroline	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	OP	op	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	metal	metal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-ion	-ion	NOUN	NN	Number=Sing	_	_	_	_
37	chelator	chelator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4353
# text = Pretreatment of HL-60 cells or thymocytes with 100-500 microM OP for 2 hr, but not 10-60 mM
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	500	500	NUM	CD	NumType=Card	_	_	_	_
13	microM	microm	PROPN	NNP	Number=Sing	_	_	_	_
14	OP	op	PROPN	NNP	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-60	-60	NUM	CD	NumType=Card	_	_	_	_
23	mM	mm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4354
# text = NAC, suppressed subsequent occurrence of apoptosis induced by etoposide.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
5	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4355
# text = These results suggest that the activation of NF-kappa B plays an important role in the apoptotic process of human hematopoietic cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
19	process	process	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4356
# text = Document 003001314 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001314	003001314	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4357
# text = LPS tolerance in monocytes/macrophages: three 3' cytosins are required in the DNA binding motif for detection of upregulated NF-kappa B p50 homodimers.
1	LPS	Lp	ADJ	JJ	Degree=Pos	_	_	_	_
2	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	cytosins	cytosin	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	upregulated	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	p50	p50	NUM	CD	NumType=Card	_	_	_	_
28	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4358
# text = When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	repeatedly	repeatedly	ADV	RB	_	_	_	_	_
11	then	then	ADV	RB	PronType=Dem	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initially	initially	ADV	RB	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	very	very	ADV	RB	_	_	_	_	_
28	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	i.e.	i.e.	X	FW	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4359
# text = Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus.
1	Tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	still	still	ADV	RB	_	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	still	still	ADV	RB	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	mobilize	mobilize	VERB	VB	VerbForm=Inf	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4360
# text = Analysis of the binding proteins employing the -605 motif of the human TNF promoter (GGGGCTGTCCC) revealed that in tolerant cells of the human monocytic cell line Mono Mac 6 there is a predominance of p50p50 of NF-kappa B.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	employing	employ	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	605	605	NUM	CD	NumType=Card	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GGGGCTGTCCC	GGGGCTGTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
31	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	there	there	PRON	EX	_	_	_	_	_
34	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p50p50	p50p50	NUM	CD	NumType=Card	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4361
# text = We now show that a mutant motif that exchanges the terminal 3' C for a G fails to bind the p50 homodimer that is upregulated in LPS toler ant human Mono Mac 6 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	exchanges	exchange	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	C	c	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	G	g	NOUN	NN	Number=Sing	_	_	_	_
18	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
29	toler	toler	ADV	RB	_	_	_	_	_
30	ant	ant	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
33	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4362
# text = The same is true for nuclear extracts taken from the murine P388D1 macrophage cell line when tested with the -516 motif of the murine TNF promoter (GGGGGCTTTCCC).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
12	P388D1	P388d1	NOUN	NN	Number=Sing	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	tested	tested	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	516	516	NUM	CD	NumType=Card	_	_	_	_
22	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
26	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	GGGGGCTTTCCC	GGGGGCTTTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4363
# text = Here the wild type motif gives efficient binding of p50p50 that again is upregulated in tolerant cells whereas a mutant with a 3' G shows hardly any binding of p50p50.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
6	gives	give	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p50p50	p50p50	NUM	CD	NumType=Card	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	again	again	ADV	RB	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	'	'	PUNCT	``	_	_	_	_	_
25	G	g	NOUN	NN	Number=Sing	_	_	_	_
26	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
27	hardly	hardly	ADV	RB	_	_	_	_	_
28	any	any	DET	DT	_	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	p50p50	p50p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4364
# text = Conversely, the murine kappa light chain enhancer motif (GGGGACTTTCCG) does not efficiently bind the nuclear p50p50 from tolerant murine P388 macrophages.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	light	light	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GGGGACTTTCCG	GGGGACTTTCCG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	p50p50	p50p50	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	tolerant	tolerant	NOUN	NN	Number=Sing	_	_	_	_
22	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
23	P388	P388	NOUN	NN	Number=Sing	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4365
# text = Binding is, however, readily detected when the 3' G is replaced by a C.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	readily	readily	ADV	RB	_	_	_	_	_
7	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	``	_	_	_	_	_
12	G	g	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4366
# text = These data show that the detection of upregulated p50 homodimers in LPS tolerant cells is dependent on subtle differences in the sequence of the DNA binding motif.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	upregulated	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
13	tolerant	tolerant	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
19	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	motif.	motif.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4367
# text = Document 003001315 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001315	003001315	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4368
# text = Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
4	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	without	without	ADP	IN	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
15	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4369
# text = Endotoxin selectively induces monocyte
1	Endotoxin	Endotoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	selectively	selectively	ADV	RB	_	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4370
# text = Mn superoxide dismutase (SOD) without affecting levels of Cu,Zn SOD, catalase, or glutathione peroxidase.
1	Mn	Mn	ADJ	JJ	Degree=Pos	_	_	_	_
2	superoxide	superoxide	NOUN	NN	Number=Sing	_	_	_	_
3	dismutase	dismutase	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SOD	Sod	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	without	without	SCONJ	IN	_	_	_	_	_
8	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Cu	Cu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Zn	Zn	PROPN	NNP	Number=Sing	_	_	_	_
14	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	glutathione	glutathione	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4371
# text = However, little is known about the structure-activity relationship and the mechanism by which endotoxin induces Mn SOD.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	about	about	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	endotoxin	endotoxin	ADP	IN	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
20	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4372
# text = In this study we demonstrated that a mutant Escherichia coli endotoxin lacking myristoyl fatty acid at the 3' R-3-hydroxymyristate position of the lipid A moiety retained its full capacity to coagulate Limulus amoebocyte lysate compared with the wild-type E. coli endotoxin and markedly stimulated the activation of human monocyte nuclear factor-kappaB and the induction of Mn SOD mRNA and enzyme activity.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
10	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
11	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
12	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
13	myristoyl	myristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
14	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
15	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	_
20	R-	R-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	hydroxymyristate	hydroxymyristate	NOUN	NN	Number=Sing	_	_	_	_
24	position	position	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	_
28	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	moiety	moiety	NOUN	NN	Number=Sing	_	_	_	_
30	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
32	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
34	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	coagulate	coagulate	VERB	VB	VerbForm=Inf	_	_	_	_
37	Limulus	Limulus	PROPN	NNP	Number=Sing	_	_	_	_
38	amoebocyte	amoebocyte	NOUN	NN	Number=Sing	_	_	_	_
39	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
40	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	type	type	NOUN	NN	Number=Sing	_	_	_	_
46	E.	E.	NOUN	NN	Number=Sing	_	_	_	_
47	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
48	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	markedly	markedly	ADV	RB	_	_	_	_	_
51	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
56	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
57	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
58	factor-kappaB	factor-kappab	NOUN	NN	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
64	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
65	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
68	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4373
# text = However, in contrast to the wild-type endotoxin, it failed to induce significant production of tumor necrosis factor-alpha and macrophage inflammatory protein-1alpha by monocytes and did not induce the phosphorylation and nuclear translocation of mitogen-activated protein kinase.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4374
# text = These results suggest that 1) lipid A myristoyl fatty acid, although it is important for the induction of inflammatory cytokine production by human monocytes, is not necessary for the induction of Mn SOD, 2) endotoxin-mediated induction of Mn SOD and inflammatory cytokines are regulated, at least in part, through different signal transduction pathways, and 3) failure of the mutant endotoxin to induce tumor necrosis factor-alpha production is, at least in part, due to its inability to activate mitogen-activated protein kinase.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	1	1	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	lipid	lipid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	myristoyl	myristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
10	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
11	acid	acid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	although	although	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
36	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	2	2	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	endotoxin-	endotoxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
41	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
45	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
48	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
49	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	at	at	ADV	RB	_	_	_	_	_
53	least	least	ADV	RBS	Degree=Sup	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	through	through	ADP	IN	_	_	_	_	_
58	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
59	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
60	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
61	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	3	3	X	LS	_	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
70	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
71	to	to	PART	TO	_	_	_	_	_
72	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
73	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
74	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
75	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
77	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
78	production	production	NOUN	NN	Number=Sing	_	_	_	_
79	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
80	,	,	PUNCT	,	_	_	_	_	_
81	at	at	ADV	RB	_	_	_	_	_
82	least	least	ADV	RBS	Degree=Sup	_	_	_	_
83	in	in	ADP	IN	_	_	_	_	_
84	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	due	due	ADP	IN	_	_	_	_	_
87	to	to	ADP	IN	_	_	_	_	_
88	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
89	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
90	to	to	PART	TO	_	_	_	_	_
91	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
92	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
93	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
94	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
95	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
96	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4375
# text = Document 003001316 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001316	003001316	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4376
# text = Of the GATA-binding proteins, only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	selectively	selectively	ADV	RB	_	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	producing	producing	VERB	VBG	VerbForm=Ger	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
30	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4377
# text = Interleukin-5 (IL-5) is produced by T lymphocytes and known to support B cell growth and eosinophilic differentiation of the progenitor cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	support	support	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
20	growth	growth	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	progenitor	progenitor	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4378
# text = Using ATL-16T cells which express IL-5 mRNA, we have identified a region, within the human IL-5 gene promoter, that regulates IL-5 gene transcription.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	ATL	Atl	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	16T	16t	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	5	5	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	5	5	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4379
# text = This cis-acting sequence contains the core binding motif, (A/T)GATA(A/G), for GATA-binding family proteins and thus suggests the involvement of these family members.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	A/T	Aetween	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	A/G	A/G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	thus	thus	ADV	RB	_	_	_	_	_
28	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4380
# text = In this report, we describe the cloning of human GATA-4 (hGATA-4) and show that hGATA-4 selectively interacts with the -70 GATA site within the IL-5 proximal promoter region.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	hGATA	hGATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	selectively	selectively	ADV	RB	_	_	_	_	_
26	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	70	70	NUM	CD	NumType=Card	_	_	_	_
31	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	5	5	NUM	CD	NumType=Card	_	_	_	_
38	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4381
# text = By promoter deletion and mutation analyses, we established this region as a positive regulatory element.
1	By	by	ADP	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4382
# text = Cotransfection experiments revealed that both hGATA-4 and PMA/A23187 stimulation are necessary for the IL-5 promoter activation.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	A23187	A23187	NUM	CD	NumType=Card	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	5	5	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4383
# text = The requirement of another regulatory element called CLE0, which lies downstream of the -70 GATA site, was also demonstrated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	another	another	DET	DT	_	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	-70	-70	NUM	CD	NumType=Card	_	_	_	_
16	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4384
# text = ATL-16T cells express mRNA of three GATA-binding proteins, hGATA-2, hGATA-3 and hGATA-4, and each of them has a potential to bind to the consensus (A/T)GATA(G/ A) motif.
1	ATL	Atl	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	16T	16t	ADJ	JJS	Degree=Sup	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	hGATA	hGATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
30	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	A/T	A/T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	G/	G/	X	ADD	_	_	_	_	_
44	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4385
# text = However, using ATL-16T nuclear extract, we demonstrated that GATA-4 is the only GATA-binding protein that forms specific DNA-protein complex with the -70 GATA site.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	16T	16T	PROPN	NNP	Number=Sing	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extract	extract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
19	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	forms	form	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	70	70	NUM	CD	NumType=Card	_	_	_	_
34	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4386
# text = The electrophoretic mobility shift assay with extracts of COS cells expressing GATA-binding proteins showed that GATA-4 has the highest binding affinity to the -70 GATA site among the three GATA-binding proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	COS	Cos	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
12	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	70	70	NUM	CD	NumType=Card	_	_	_	_
30	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	among	among	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	three	three	NUM	CD	NumType=Card	_	_	_	_
35	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4387
# text = When the transactivation ability was compared among the three, GATA-4 showed the highest activity.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	among	among	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4388
# text = These results demonstrate the selective role of GATA-4 in the transcriptional regulation of the IL-5 gene in a circumstance where multiple members of the GATA-binding proteins are expressed.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	circumstance	circumstance	NOUN	NN	Number=Sing	_	_	_	_
24	where	where	ADV	WRB	PronType=Rel	_	_	_	_
25	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4389
# text = Document 003001317 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001317	003001317	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4390
# text = Expression of erythroid-specific genes in megakaryoblastic disorders.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
9	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4391
# text = Currently available data indicate that erythroid and megakaryocytic differentiation pathways are closely related to each other, and there may exist progenitor cells common to those two lineages may exist.
1	Currently	currently	ADV	RB	_	_	_	_	_
2	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	closely	closely	ADV	RB	_	_	_	_	_
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	each	each	DET	DT	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	there	there	PRON	EX	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	_
22	progenitor	progenitor	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4392
# text = Acute megakaryoblastic leukemia (AML-M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AML	aml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	M7	M7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
11	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Down	Down	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
24	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
27	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4393
# text = These blast cells express lineage-specific transcription factors such as GATA-1 common to these lineages and frequently express erythroid-specific mRNAs such as gamma-globin and erythroid delta-aminolevulinate synthase (ALAS-E), indicating that most of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	common	common	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	frequently	frequently	ADV	RB	_	_	_	_	_
21	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
33	delta-	delta-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	aminolevulinate	aminolevulinate	ADJ	JJ	Degree=Pos	_	_	_	_
35	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ALAS	Alas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
43	that	that	SCONJ	IN	_	_	_	_	_
44	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
52	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
53	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
54	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
57	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4394
# text = These results suggest that blasts in M7 and TMD may correspond to progenitors of both erythroid and megakaryocytic lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	correspond	correspond	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4395
# text = Document 003001318 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001318	003001318	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4396
# text = Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation.
1	Replication	Replication	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	control	control	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4397
# text = Tumor necrosis factor (TNF)-alpha controls T-cell activation and is a major inducer of human immunodeficiency virus (HIV)-1 replication in chronically infected cells.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
10	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	chronically	chronically	ADV	RB	_	_	_	_	_
30	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4398
# text = Therefore, we have investigated its role in primary cultures of HIV-infected human T lymphocytes by using neutralizing anti-TNF-alpha antibodies or TNF-alpha.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
7	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
21	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4399
# text = Primary resting
1	Primary	primary	X	GW	_	_	_	_	_
2	resting	resting	X	ADD	_	_	_	_	_

# sent_id = 4400
# text = T lymphocytes produced TNF-alpha and supported HIV replication after T-cell receptor activation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4401
# text = Addition of neutralizing anti-TNF-alpha antibodies drastically reduced p24 antigen release and prevented CD4+ cell depletion associated with infection.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
4	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
8	drastically	drastically	ADV	RB	_	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	p24	p24	NUM	CD	NumType=Card	_	_	_	_
11	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
12	release	release	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4402
# text = Anti-TNF-alpha also prevented nuclear factor-kappa B (NF-kappa B) activation, and a good correlation between this inhibition and inhibition of HIV replication was observed.
1	Anti-TNF	Anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	good	good	ADJ	JJ	Degree=Pos	_	_	_	_
22	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4403
# text = Moreover, supplementing the cultures with high doses of IL-2 reverted anti-TNF-alpha inhibition of cell proliferation but did not affect the inhibition of HIV p24 antigen release or NF-kappa B activation in the same cultures.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	supplementing	supplement	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	reverted	revert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
29	p24	p24	NUM	CD	NumType=Card	_	_	_	_
30	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
31	release	release	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
41	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4404
# text = Moreover, anti-TNF-alpha inhibited HIV-1 long terminal repeat (LTR)-driven transcription of a reporter gene in primary T cells in response to activation, either in the presence or the absence of HIV-1 Tat.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	alpha	alpha	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4405
# text = Our results support an important role for autocrine TNF-alpha secretion in controlling HIV replication in primary T cells because of its ability to maintain NF-kappa B elevated in the nucleus of T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	because	because	ADP	IN	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4406
# text = Document 003001319 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001319	003001319	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4407
# text = A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
25	assignment	assignment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4408
# text = Lipopolysaccharide (LPS) is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor alpha (TNF-alpha) and other inflammatory mediators.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
8	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
15	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4409
# text = Given the deleterious effects to the host of TNF-alpha, it has been postulated that TNF-alpha gene expression must be tightly regulated.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	deleterious	deleterious	ADJ	JJ	Degree=Pos	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	host	host	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	tightly	tightly	ADV	RB	_	_	_	_	_
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4410
# text = The nature of the nuclear factor(s) that control TNF-alpha gene transcription in humans remains obscure, although NF-kappaB has been suggested.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
19	remains	remains	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	obscure	obscure	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	although	although	SCONJ	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4411
# text = Our previous studies pertaining to macrophage response to LPS identified a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity, but lacks any known NF-kappaB-binding sites.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	pertaining	pertai	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	macrophage	macrophage	VERB	VB	VerbForm=Inf	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
10	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	550	550	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	487	487	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	any	any	DET	DT	_	_	_	_	_
39	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4412
# text = We have used this DNA fragment to isolate and purify a 60-kDa protein binding to this fragment and obtained its amino-terminal sequence, which was used to design degenerate probes to screen a cDNA library from THP-1 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	purify	purify	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	design	design	VERB	VB	VerbForm=Inf	_	_	_	_
33	degenerate	degenerate	ADJ	JJ	Degree=Pos	_	_	_	_
34	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
39	library	library	NOUN	NN	Number=Sing	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4413
# text = A novel cDNA clone (1.8 kb) was isolated and fully sequenced.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
7	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	fully	fully	ADV	RB	_	_	_	_	_
13	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4414
# text = Characterization of this cDNA clone revealed that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF).
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	clone	clone	PRON	NN	Number=Sing	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	name	name	NOUN	NN	Number=Sing	_	_	_	_
25	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4415
# text = Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4416
# text = In addition, high level of expression of LITAF mRNA was observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes, and the spleen.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	predominantly	predominantly	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	placenta	placenta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
23	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4417
# text = Finally, chromosomal localization using fluorescence in situ hybridization revealed that LITAF mapped to chromosome 16p12-16p13.3.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
4	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
9	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
13	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	chromosome	chromosome	VERB	VB	VerbForm=Inf	_	_	_	_
16	16p12-16p13.3	16p12-16p13.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4418
# text = Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	proposes	propose	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4419
# text = Document 003001320 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001320	003001320	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4420
# text = Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	molecule/CD69	molecule/cd69	NOUN	NN	Number=Sing	_	_	_	_
11	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4421
# text = The induction of the AP-1 transcription factor has been ascribed to the early events leading to T cell differentiation and activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	ascribed	ascribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	events	event	NOUN	NNS	Number=Plur	_	_	_	_
17	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4422
# text = We have studied the regulation of AP-1 activity in human peripheral blood T lymphocytes stimulated through the activation inducer molecule (AIM)/CD69 activation pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
22	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	AIM	aim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	/CD69	/CD69	NUM	CD	NumType=Card	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4423
# text = Phorbol esters are required to induce AIM/CD69 cell-surface expression as well as for triggering the proliferation of T cells in conjunction with anti-AIM mAb.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	AIM/CD69	AIM/CD69	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	for	for	SCONJ	IN	_	_	_	_	_
16	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
26	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
27	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4424
# text = Mobility shift assays showed that addition of anti-AIM mAb to PMA-treated T lymphocytes markedly enhanced the binding activity of AP-1 to its cognate sequence, the phorbol ester response element.
1	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	ADV	RB	_	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	markedly	markedly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	cognate	cognate	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
33	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4425
# text = In contrast, anti-AIM mAb did not induce any change in the binding activity of NF-kappa B, a transcription factor whose activity is also regulated by protein kinase C.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
5	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	any	any	DET	DT	_	_	_	_	_
11	change	change	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4426
# text = The increase in AP-1-binding activity was accompanied by the marked stimulation of the transcription of c-fos but not that of c-jun.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4427
# text = Blockade of the DNA-binding complexes with an anti-Fos mAb demonstrated a direct participation of c-Fos in the AP-1 complexes induced by anti-AIM mAb.
1	Blockade	Blockade	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
11	-Fos	-Fos	PROPN	NNP	Number=Sing	_	_	_	_
12	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
16	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	AIM	aim	PROPN	NNP	Number=Sing	_	_	_	_
32	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4428
# text = Most of the AP-1 activity could be eliminated when the anti-AIM mAb was added to the culture medium in the presence of cycloheximide, suggesting that de novo protein synthesis is crucial for the induction of AP-1-binding activity.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
14	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
15	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
21	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	de	de	PROPN	NNP	Number=Sing	_	_	_	_
31	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4429
# text = These data provide the evidence that activation of human peripheral blood T cells through the AIM activation pathway regulate the activity of AP-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	AIM	aim	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4430
# text = Therefore, this pathway appears as a crucial step in the initiation of early T cell activation events.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	step	step	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4431
# text = Document 003001321 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001321	003001321	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4432
# text = A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Ets-	Ets-	X	GW	_	_	_	_	SpaceAfter=No
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	CTL	CTL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
21	perforin	perforin	ADP	IN	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4433
# text = This study was designed to determine the potential cis-elements involved in transcriptional regulation of the mouse perforin gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
19	perforin	perforin	ADP	IN	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4434
# text = DNase I hypersensitive site (DHS) mapping revealed that the perforin locus contained six DHS within 7.0 kb of the 5' upstream sequence (-7.0 kb) and two DHS in intron 2.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	DHS	DHS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	perforin	perforin	NOUN	NN	Number=Sing	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	six	six	NUM	CD	NumType=Card	_	_	_	_
16	DHS	D	NOUN	NNS	Number=Plur	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	7.0	7.0	NUM	CD	NumType=Card	_	_	_	_
19	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	_
24	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
25	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	7.0	7.0	NUM	CD	NumType=Card	_	_	_	_
29	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	two	two	NUM	CD	NumType=Card	_	_	_	_
33	DHS	D	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4435
# text = The six 5' upstream and one intronic DHS were detected in only perforin-expressing lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	six	six	NUM	CD	NumType=Card	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	''	_	_	_	_	_
5	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
9	DHS	D	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	perforin	perforin	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4436
# text = Chloramphenicol acetyltransferase (CAT) activities directed by 5' upstream promoter were detected preferentially in perforin-expressing cell lines.
1	Chloramphenicol	Chloramphenicol	PROPN	NNP	Number=Sing	_	_	_	_
2	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	preferentially	preferentially	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	perforin	perforin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4437
# text = A construct termed PFP5a containing -795 bp exhibited the highest CAT activity, and PFP9a20 containing only -73 bp also produced significantly high CAT activity in CTLL-R8 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
3	termed	term	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	PFP5	PFP5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	795	795	NUM	CD	NumType=Card	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
10	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
13	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	PFP9a20	PFP9a20	PROPN	NNP	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	73	73	NUM	CD	NumType=Card	_	_	_	_
22	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	R8	R8	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4438
# text = The proximal region in PFP9a20 contained two potential Sp1 binding sites (GC box and GT box) and one Ets binding site (EBS).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	PFP9a20	PFP9a20	NUM	CD	NumType=Card	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
9	Sp1	Sp1	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
14	box	box	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
17	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4439
# text = Electrophoretic mobility shift assay showed that each of the cis-elements bound specific protein factors.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-elements	-element	NOUN	NNS	Number=Plur	_	_	_	_
12	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4440
# text = When single-point mutation was introduced to each GC box, EBS, and GT box in PFP9a20, at least 3-fold less CAT activity was observed in CTLL-R8 cells.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	point	point	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	each	each	DET	DT	_	_	_	_	_
10	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
11	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	PFP9a20	PFP9a20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	at	at	ADV	RB	_	_	_	_	_
22	least	least	ADV	RBS	Degree=Sup	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
27	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	R8	R8	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4441
# text = To confirm the importance of the three cis-acting elements in the perforin gene expression, point mutation was introduced again to each proximal GC box, EBS, and GT box of PFP5a.
1	To	to	PART	TO	_	_	_	_	_
2	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-acting	-acting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	perforin	perforin	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	point	point	NOUN	NN	Number=Sing	_	_	_	_
18	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	again	again	ADV	RB	_	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	each	each	DET	DT	_	_	_	_	_
24	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
25	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
26	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	GT	gt	NOUN	NN	Number=Sing	_	_	_	_
32	box	box	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PFP5	PFP5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4442
# text = The point mutations resulted in a 2.5- to 3-fold reduction of CAT activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	point	point	NOUN	NN	Number=Sing	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4443
# text = The results suggest that a combination of the three proximal cis-acting elements may constitute a minimal region responsible for CTL-specific expression of perforin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	CTL	CTL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	perforin	perforin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4444
# text = Document 003001322 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001322	003001322	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4445
# text = Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	downmodulates	downmodulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA1	Gata1	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	adult	adult	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4446
# text = All-trans retinoic acid (RA) is an important morphogen in vertebrate development, a normal constituent in human adult blood and is also involved in the control of cell growth and differentiation in acute promyelocytic leukemia.
1	All	all	DET	DT	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
4	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	morphogen	morphogen	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	constituent	constituent	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	also	also	ADV	RB	_	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
38	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4447
# text = We have examined the effects of RA on normal hematopoiesis by using early hematopoietic progenitor cells (HPC) stringently purified from adult peripheral blood.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	early	early	ADV	RB	Degree=Pos	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	stringently	stringently	ADV	RB	_	_	_	_	_
21	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4448
# text = In clonogenetic fetal calf serum-supplemented (FCS+) or -nonsupplemented (FCS-) culture treated with saturating levels of interleukin-3 (IL-3) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Ep) (combined with c-kit ligand in FCS(-)-culture conditions), RA induces a dramatic dose-dependent shift from erythroid to granulomonocytic colony formation, the latter colonies being essentially represented by granulocytic clones.
1	In	in	ADP	IN	_	_	_	_	_
2	clonogenetic	clonogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
4	calf	calf	NOUN	NN	Number=Sing	_	_	_	_
5	serum-	serum-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	FCS	FCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	nonsupplemented	nonsupplemented	ADJ	JJ	Degree=Pos	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	FCS	Fcs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	saturating	saturating	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	Ep	Ep	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
53	kit	kit	NOUN	NN	Number=Sing	_	_	_	_
54	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	FCS	FCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
61	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
65	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
66	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
67	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
68	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
71	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
72	from	from	ADP	IN	_	_	_	_	_
73	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
74	to	to	ADP	IN	_	_	_	_	_
75	granulomonocytic	granulomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
76	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
77	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	,	,	PUNCT	,	_	_	_	_	_
79	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
80	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
81	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
82	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
83	essentially	essentially	ADV	RB	_	_	_	_	_
84	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
85	by	by	ADP	IN	_	_	_	_	_
86	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
87	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
88	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4449
# text = This shift is apparently not caused by a recruitment phenomenon, because in FCS+ culture, the total number of colonies is not significantly modified by RA addition.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	apparently	apparently	ADV	RB	_	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
10	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	because	because	SCONJ	IN	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	FCS	FCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
29	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4450
# text = In FCS- liquid-suspension culture supplemented with saturating Ep level and low-dose IL-3/GM-CSF, adult HPC undergo unilineage erythropoietic differentiation:
1	In	in	ADP	IN	_	_	_	_	_
2	FCS	FCS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	_
4	liquid	liquid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	suspension	suspension	NOUN	NN	Number=Sing	_	_	_	_
7	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
8	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	SCONJ	IN	_	_	_	_	_
10	saturating	saturat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	Ep	Ep	PROPN	NNP	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
17	IL-3/GM	IL-3/Gm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
22	HPC	Hpc	NOUN	NN	Number=Sing	_	_	_	_
23	undergo	undergo	NOUN	NN	Number=Sing	_	_	_	_
24	unilineage	unilineage	NOUN	NN	Number=Sing	_	_	_	_
25	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4451
# text = Here again, treatment with high-dose RA induces a shift from the erythroid to granulocytic differentiation pathway.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	again	again	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
9	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4452
# text = Studies on RA time-response or pulse treatment in semisolid or liquid culture show that early RA addition is most effective, thus indicating that early but not late HPC are sensitive to its action.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
4	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	semisolid	semisolid	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	liquid	liquid	ADJ	JJ	Degree=Pos	_	_	_	_
14	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	RA	RA	NOUN	NN	Number=Sing	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	thus	thus	ADV	RB	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
31	HPC	Hpc	PROPN	NNPS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4453
# text = We then analyzed the expression of the master GATA1 gene, which encodes a finger transcription factor required for normal erythroid development; addition of RA to HPC stimulated into unilineage erythropoietic differentiation in liquid culture caused a virtually complete inhibition of GATA1 mRNA induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	then	then	ADV	RB	PronType=Dem	_	_	_	_
3	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	master	master	NOUN	NN	Number=Sing	_	_	_	_
9	GATA1	GATA1	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	unilineage	unilineage	ADJ	JJ	Degree=Pos	_	_	_	_
32	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	liquid	liquid	ADJ	JJ	Degree=Pos	_	_	_	_
36	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
37	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	virtually	virtually	ADV	RB	_	_	_	_	_
40	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
41	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	GATA1	GATA1	PROPN	NNP	Number=Sing	_	_	_	_
44	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4454
# text = These results indicate that RA directly inhibits the erythroid differentiation program at the level of early adult HPC, and may lead to a shift from the erythroid to granulocytic differentiation pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	program	program	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	level	level	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
17	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
18	HPC	Hpc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
32	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4455
# text = This phenomenon is correlated with inhibition of GATA1 induction in the early stages of erythropoietic differentiation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA1	GATA1	NUM	CD	NumType=Card	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4456
# text = Document 003001323 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001323	003001323	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4457
# text = STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.
1	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4458
# text = A signal transduction pathway activated by many cytokines has recently been elaborated.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	recently	recently	ADV	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	elaborated	elaborate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4459
# text = The JAK kinases and the signal transducers and activators of transcription (STAT) factors have been found to be essential components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4460
# text = In this report, we describe the presence of constitutively activated
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 4461
# text = STAT factors in peripheral blood cells from patients with acute leukemia.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4462
# text = We used oligonucleotide probes from the beta-casein and IRF-1 gene promoters and the ISRE probe to detect STAT proteins in nuclear extracts from acute leukemia cells in bandshift assays.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ISRE	Isre	ADJ	JJ	Degree=Pos	_	_	_	_
19	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
22	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	bandshift	bandshift	ADJ	JJ	Degree=Pos	_	_	_	_
33	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4463
# text = Specific DNA protein complex formation was observed with the probes from the beta-casein and IRF-1 gene promoters, but not with the ISRE oligonucleotide probe, when cell extracts from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were investigated.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
5	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ISRE	Isre	NOUN	NN	Number=Sing	_	_	_	_
28	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
29	probe	probe	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	when	when	ADV	WRB	PronType=Int	_	_	_	_
32	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
36	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
37	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	acute	acute	VERB	VB	VerbForm=Inf	_	_	_	_
43	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	AML	aml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4464
# text = We used nonradioactive oligonucleotides as competitors to show the specificity of the complex formation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	nonradioactive	nonradioactive	ADJ	JJ	Degree=Pos	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	competitors	competitor	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
14	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4465
# text = Specific antibodies directed against the individual STAT proteins were used in supershift experiments.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	against	against	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
13	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4466
# text = STAT5- and STAT1-related factors were detected in ALL and STAT1-, STAT3-, and STAT5-related proteins were present in nuclear cell extracts from AML.
1	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	ALL	all	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	AML	AML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4467
# text = Since the cells were not treated with cytokines before the nuclear proteins were extracted, we conclude that these factors are constitutively activated in vivo.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	constitutively	constitutively	ADV	RB	_	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4468
# text = It is likely that the constitutive activation of
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_

# sent_id = 4469
# text = STAT proteins is a part of the events of leukemogenesis.
1	STAT	Stat	PRON	WP	PronType=Int	_	_	_	_
2	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	part	part	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	leukemogenesis	leukemogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4470
# text = Document 003001324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001324	003001324	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4471
# text = Functional antagonism between vitamin D3 and retinoic acid in the regulation of CD14 and CD23 expression during monocytic differentiation of U-937 cells.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
5	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	14	14	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	937	937	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4472
# text = 1,25 alpha-Dihydroxicholecalciferol (VitD3) and retinoic acid (RA) are important regulators of the proliferation and differentiation of several cell types.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	Dihydroxicholecalciferol	Dihydroxicholecalciferol	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	VitD3	VitD3	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4473
# text = This paper describes how the expression of the monocyte-macrophage
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
3	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	how	how	ADV	WRB	PronType=Int	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	monocyte-	monocyte-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4474
# text = Ag, CD14, and the low affinity Fc receptor for IgE, CD23, were inversely regulated during VitD3- and RA-induced monocytic differentiation of human U-937 monoblasts.
1	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
9	Fc	Fc	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	inversely	inversely	ADV	RB	_	_	_	_	_
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	937	937	NUM	CD	NumType=Card	_	_	_	_
33	monoblasts	monoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4475
# text = PMA induced the expression of both CD14 and CD23 mRNA and protein.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	14	14	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4476
# text = Exposure to VitD3 rapidly induced the de novo expression of CD14 mRNA and protein.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
4	rapidly	rapidly	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	de	de	PROPN	NNP	Number=Sing	_	_	_	_
8	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4477
# text = The addition of cycloheximide completely blocked the VitD3 induction of CD14 mRNA expression, indicating that the induction was dependent on ongoing protein synthesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
5	completely	completely	ADV	RB	_	_	_	_	_
6	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	VitD3	VitD3	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4478
# text = While inducing CD14 expression, VitD3 concomitantly suppressed the basal, PMA-, and RA-inducible CD23 expression in a dose-dependent manner.
1	While	while	SCONJ	IN	_	_	_	_	_
2	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
3	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
8	concomitantly	concomitantly	ADV	RB	_	_	_	_	_
9	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	basal	basal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4479
# text = In contrast, U-937 cells induced by RA strongly increased their expression of CD23 mRNA and protein, whereas they completely lacked detectable CD14 cell surface or mRNA expression.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	937	937	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
11	strongly	strongly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
23	completely	completely	ADV	RB	_	_	_	_	_
24	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
26	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	14	14	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4480
# text = Furthermore, the VitD3- and the PMA-induced CD14 expression was inhibited as a temporal consequence of the RA-induced differentiation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	VitD3	VitD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
19	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4481
# text = The results suggest that there exists a functional antagonism between VitD3 and RA that may have important implications for the regulation of certain immune and inflammatory responses through their inverse effects on CD14 and CD23 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
24	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	inverse	inverse	NOUN	NN	Number=Sing	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	14	14	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4482
# text = Document 003001325 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001325	003001325	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4483
# text = Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	nephropathy	nephropathy	ADJ	JJ	Degree=Pos	_	_	_	_
11	show	show	NOUN	NN	Number=Sing	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4484
# text = Increased oxidative stress and subsequent activation of the transcription factor NF-kappaB has been linked to the development of late diabetic complications.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
3	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
22	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	complications	complication	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4485
# text = To determine whether oxidative stress dependent NF-kappaB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kappaB activation in ex vivo isolated peripheral blood mononuclear cells.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
5	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
17	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	Electrophoretic	Electrophoretic	PROPN	NNP	Number=Sing	_	_	_	_
22	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
23	Shift	shift	PROPN	NNP	Number=Sing	_	_	_	_
24	Assay	assay	PROPN	NNP	Number=Sing	_	_	_	_
25	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
27	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	enabled	enable	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
40	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
41	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
43	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
44	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4486
# text = We examined 33 patients with diabetes mellitus (Type I and
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	33	33	NUM	CD	NumType=Card	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
7	mellitus	mellitus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	Type	type	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_

# sent_id = 4487
# text = Type II).
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4488
# text = Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
4	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Electrophoretic	Electrophoretic	PROPN	NNP	Number=Sing	_	_	_	_
14	Mobility	Mobility	PROPN	NNP	Number=Sing	_	_	_	_
15	Shift	shift	PROPN	NNP	Number=Sing	_	_	_	_
16	Assays	Assays	PROPN	NNPS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
19	immunohistological	immunohistological	ADJ	JJ	Degree=Pos	_	_	_	_
20	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaBp65	kappaBp65	PROPN	NNP	Number=Sing	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	without	without	ADP	IN	_	_	_	_	_
29	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
30	complications	complication	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4489
# text = NF-kappaB binding activity correlated with the degree of albuminuria (r = 0.316) and with thrombomodulin plasma concentrations (r = 0.33), indicative for albuminuria associated endothelial dysfunction.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	albuminuria	albuminuria	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	r	be	NOUN	NN	Number=Sing	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	0.316	0.316	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	thrombomodulin	thrombomodulin	NOUN	NN	Number=Sing	_	_	_	_
20	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	r	be	NOUN	NN	Number=Sing	_	_	_	_
24	=	=	SYM	SYM	_	_	_	_	_
25	0.33	0.33	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicative	indicative	ADJ	JJ	Degree=Pos	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	albuminuria	albuminurion	X	GW	_	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
33	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4490
# text = In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (alpha-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48% and NF-kappaB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38%.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	day	day	NOUN	NN	Number=Sing	_	_	_	_
5	intervention	intervention	NOUN	NN	Number=Sing	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	600	600	NUM	CD	NumType=Card	_	_	_	_
10	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
14	thioctic	thioctic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
20	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	per	per	ADP	IN	_	_	_	_	_
23	day	day	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	given	give	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	nine	nine	NUM	CD	NumType=Card	_	_	_	_
28	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	_
32	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
33	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
36	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	%	%	SYM	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
50	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
51	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
53	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
54	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
56	by	by	ADP	IN	_	_	_	_	_
57	38%	38%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4491
# text = In conclusion, activation of the transcription factor NF-kappaB in ex vivo isolated peripheral blood mononuclear cells of patients with diabetes mellitus correlates with the degree of diabetic nephropathy.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	ex	ex	NUM	CD	NumType=Card	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
24	mellitus	mellitus	CCONJ	CC	_	_	_	_	_
25	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4492
# text = NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	at	at	ADV	RB	_	_	_	_	_
7	least	least	ADV	RBS	Degree=Sup	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	part	part	ADJ	JJ	Degree=Pos	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
13	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
14	since	since	ADP	IN	_	_	_	_	_
15	thioctic	thioctic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4493
# text = Document 003001326 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001326	003001326	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4494
# text = Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4495
# text = Cells of the monocyte-macrophage lineage are important targets of HIV infection.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
7	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4496
# text = We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor alpha (TNF alpha) is associated with expression of nuclear factor kappa B (NF-kappa B).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4497
# text = In parallel with such differentiation, HIV transcription, monitored using an HIV long terminal repeat reporter gene construct, is activated in such cells under the influence of enhanced NF-kappa B expression.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
14	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
15	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
16	repeat	repeat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4498
# text = Also, in a promonocyte cell line chronically infected with HIV, NF-kappa B expression and HIV transcription were enhanced on stimulation with phorbol ester or TNF alpha.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promonocyte	promonocyte	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	chronically	chronically	ADV	RB	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
27	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
30	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4499
# text = Thus, stimulation of monocyte cell lines by phorbol esters or TNF alpha induces cell differentiation and activates HIV transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
10	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha	alpha	ADV	RB	_	_	_	_	_
14	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4500
# text = Such a process may have fundamental implications in AIDS pathogenesis in vivo and may be important in disease progression induced by opportunistic infections directly or indirectly involving macrophages.
1	Such	such	DET	PDT	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	process	process	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
6	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
7	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
10	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
19	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	opportunistic	opportunistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
24	directly	directly	ADV	RB	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	indirectly	indirectly	ADV	RB	_	_	_	_	_
27	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4501
# text = Document 003001327 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001327	003001327	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4502
# text = Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.
1	Hypoxia	Hypoxia	PROPN	NNP	Number=Sing	_	_	_	_
2	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
16	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4503
# text = The response of mammalian cells to stress is controlled by transcriptional regulatory proteins such as nuclear factor kappa B (NF-kappa B) to induce a wide variety of early response genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
30	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4504
# text = In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	0.02	0.02	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	_
16	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	results	result	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	X	GW	_	_	_	_	_
22	B	b	X	GW	_	_	_	_	_
23	alpha	alpha	X	GW	_	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
42	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
43	two	two	NUM	CD	NumType=Card	_	_	_	_
44	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
49	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
50	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4505
# text = Pretreatment of cells with protein tyrosine kinase inhibitors and the dominant negative allele of c-Raf-1 (Raf 301) inhibited I kappa B alpha degradation, NF-kappa B binding, and transactivation of kappa B reporter constructs by hypoxia.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	_
22	301	301	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	_
42	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
43	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4506
# text = To demonstrate a direct link between changes in the phosphorylation pattern of I kappa B alpha with NF-kappa B activation, we immunoprecipitated I kappa B alpha after varying times of hypoxic exposure and found that its tyrosine phosphorylation status increased during hypoxic exposure.
1	To	to	PART	TO	_	_	_	_	_
2	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	link	link	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	immunoprecipitated	immunoprecipitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	alpha	alpha	ADV	RB	_	_	_	_	_
30	after	after	SCONJ	IN	_	_	_	_	_
31	varying	vary	VERB	VBG	VerbForm=Ger	_	_	_	_
32	times	time	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
35	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
41	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
42	status	status	NOUN	NN	Number=Sing	_	_	_	_
43	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	during	during	ADP	IN	_	_	_	_	_
45	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
46	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4507
# text = Inhibition of the transfer of tyrosine phosphoryl groups onto I kappa B alpha prevented I kappa B alpha degradation and NF-kappa B binding.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphoryl	phosphoryl	NOUN	NN	Number=Sing	_	_	_	_
8	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
9	onto	onto	ADP	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	B	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha	alpha	ADV	RB	_	_	_	_	_
14	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	ADP	IN	_	_	_	_	_
19	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4508
# text = In comparison to other activators of NF-kappa B such as phorbol myristate acetate or tumor necrosis factor, we did not detect changes in the tyrosine phosphorylation status of I kappa B alpha following treatment with either of these agents.
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
14	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
15	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
25	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
29	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
30	status	status	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
37	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	either	either	CCONJ	CC	_	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4509
# text = These results suggest that tyrosine phosphorylation of I kappa B alpha during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	step	step	NOUN	NN	Number=Sing	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	precedes	precede	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4510
# text = Document 003001328 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001328	003001328	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4511
# text = NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4512
# text = C5a, a potent peptide chemoattractant, stimulates interleukin-8 (IL-8) secretion from peripheral blood mononuclear cells (PBMC).
1	C5a	C5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
6	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	8	8	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4513
# text = Experiments were conducted to understand the mechanisms for C5a-induced IL-8 production, which was 14-fold greater than that in unstimulated cells by 2 hours.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	a-	a-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
22	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4514
# text = IL-8 secretion was accompanied by accumulation of IL-8 mRNA in the cytosol and by nuclear expression of a kappaB DNA binding activity within 30 minutes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	8	8	NUM	CD	NumType=Card	_	_	_	_
4	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	within	within	ADP	IN	_	_	_	_	_
28	30	30	NUM	CD	NumType=Card	_	_	_	_
29	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4515
# text = AP-1 but not NF-IL-6 DNA binding activity was also detected in C5a-stimulated PBMC; however, its delayed expression (maximal at 4 hours) suggested a less important role in the rapid production of IL-8.
1	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
26	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	delayed	delay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
38	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
43	production	production	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4516
# text = The correlation between C5a-induced kappaB binding activity and IL-8 gene expression was examined in the RAW264.7 macrophage cells using reporter genes directed by the kappaB sequence from IkappaBalpha and IL-8 promoter regions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	8	8	NUM	CD	NumType=Card	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4517
# text = C5a-induced reporter gene expression was abolished by introducing mutations into the kappaB sites and by coexpression of a dominant negative IkappaBalpha construct resistant to agonist-induced phosphorylation.
1	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	introducing	introduce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
24	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
25	construct	construct	ADJ	JJ	Degree=Pos	_	_	_	_
26	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	agonist	agonist	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
29	-induced	-induce	ADJ	JJ	Degree=Pos	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4518
# text = Pertussis toxin, which ADP-ribosylates the Gi proteins known to couple to the C5a receptor, produced minimal inhibition of C5a-induced IL-8 expression and had little effect on C5a-induced calcium mobilization in RAW264.7 cells.
1	Pertussis	Pertussis	PROPN	NNP	Number=Sing	_	_	_	_
2	toxin	toxin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	ADP	ADP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	ribosylates	ribosylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	couple	couple	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	a-	a-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	8	8	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
34	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
40	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4519
# text = These results suggest that NF-kappaB activation is required for C5a-induced IL-8 gene expression and that this response is mediated primarily through a pertussis toxin-insensitive pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	primarily	primarily	ADV	RB	_	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	pertussis	pertussis	NOUN	NN	Number=Sing	_	_	_	_
30	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
33	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4520
# text = Document 003001329 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001329	003001329	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4521
# text = CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes.
1	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
15	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
21	multi-protein	multi-protein	NOUN	NN	Number=Sing	_	_	_	_
22	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4522
# text = Precise regulation of MHC class II expression plays a crucial role in the control of the immune response.
1	Precise	precise	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4523
# text = The transactivator CIITA behaves as a master controller of constitutive and inducible MHC class II gene activation, but its exact mechanism of action is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
3	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
4	behaves	behave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	master	master	NOUN	NN	Number=Sing	_	_	_	_
8	controller	controller	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	exact	exact	ADV	RB	_	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	action	action	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4524
# text = Activation of MHC class II promoters requires binding of at least three distinct multi-protein complexes (RFX, X2BP and NF-Y).
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	at	at	ADV	RB	_	_	_	_	_
11	least	least	ADV	RBS	Degree=Sup	_	_	_	_
12	three	three	NUM	CD	NumType=Card	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	multi-protein	multi-protein	NOUN	NN	Number=Sing	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	X2BP	X2BP	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4525
# text = It is known that the stability of this binding results from cooperative interactions between these proteins.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4526
# text = We show here that expression of CIITA in MHC class II- cells triggers occupation of the promoters by these complexes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
15	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4527
# text = This observation raised the possibility that the effect of CIITA on promoter occupation is mediated by an effect on the cooperative stabilization of the DNA-bound multi-protein complexes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	raised	raise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
22	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
28	multi-protein	multi-protein	NOUN	NN	Number=Sing	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4528
# text = We show, however, that the presence of CIITA does not affect the stability of the higher-order protein complex formed on DNA by RFX, X2BP and NF-Y.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	order	order	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	X2BP	X2BP	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4529
# text = This suggests other mechanisms for CIITA-induced promoter occupancy, such as an effect on chromatin structure leading to increased accessibility of MHC class II promoters.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
18	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
19	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	accessibility	accessibility	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4530
# text = This ability of CIITA to facilitate promoter occupation is undissociable from its transactivation potential.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	undissociable	undissociable	ADJ	JJ	Degree=Pos	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
14	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4531
# text = Finally, we conclude that this effect of CIITA is cell-type specific, since expression of CIITA is not required for normal occupation of MHC class II promoters in B lymphocytes.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	since	since	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4532
# text = Document 003001330 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001330	003001330	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4533
# text = Activation of distinct transcription factors in neutrophils by bacterial LPS, interferon-gamma, and GM-CSF and the necessity to overcome the action of endogenous proteases.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	necessity	necessity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4534
# text = Human neutrophils can be induced to actively transcribe a number of early-response genes, in particular those encoding cytokines, chemokines, and the high-affinity surface receptor for IgG, FcgammaRI.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	actively	actively	ADV	RB	_	_	_	_	_
8	transcribe	transcribe	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	number	number	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
19	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	FcgammaRI	FcgammaRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4535
# text = Although little is known to date about the regulation of gene transcription in neutrophils, several indications point to a role for distinct transcription factors, such as members of the NF-kappaB and STAT families.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	date	date	NOUN	NN	Number=Sing	_	_	_	_
7	about	about	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	indications	indication	NOUN	NNS	Number=Plur	_	_	_	_
18	point	point	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	members	member	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
37	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4536
# text = In this study, we investigated whether these transcription factors become activated under stimulatory conditions which are known to induce gene transcription in neutrophils.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	under	under	ADP	IN	_	_	_	_	_
14	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4537
# text = Unexpectedly, we found that conventional procedures employed to prepare cellular extracts cause the release of proteolytic activities that are normally stored in intracellular granules, resulting in the degradation of various NF-kappaB/Rel and STAT proteins.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
7	procedures	procedure	NOUN	NNS	Number=Plur	_	_	_	_
8	employed	employ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	prepare	prepare	VERB	VB	VerbForm=Inf	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	cause	cause	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	release	release	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	normally	normally	ADV	RB	_	_	_	_	_
22	stored	store	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4538
# text = To circumvent this problem, we developed an alternative procedure which allowed us to show that in neutrophils, LPS and TNFalpha induce a NF-kappaB DNA-binding activity which essentially consists of p50/RelA dimers, and that IFNgamma promotes the binding of STAT1 homodimers to the IFNgamma response region of the FcgammaRI promoter.
1	To	to	PART	TO	_	_	_	_	_
2	circumvent	circumvent	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	problem	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
10	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	essentially	essentially	ADV	RB	_	_	_	_	_
34	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
37	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	_
38	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
43	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
48	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
52	response	response	NOUN	NN	Number=Sing	_	_	_	_
53	region	region	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	FcgammaRI	FcgammaRI	PROPN	NNP	Number=Sing	_	_	_	_
57	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4539
# text = Moreover, we report that neutrophil stimulation with GM-CSF results in the formation of a STAT5-containing DNA-binding activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	results	result	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4540
# text = Collectively, the current findings open new perspectives about mechanisms that are likely to regulate gene transcription in neutrophils.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	perspectives	perspective	NOUN	NNS	Number=Plur	_	_	_	_
9	about	about	ADP	IN	_	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4541
# text = In addition, the procedure described herein could prove useful in other cell types that express high levels of endogenous proteases.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	herein	herein	ADV	RB	_	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
10	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	types	type	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4542
# text = Document 003001331 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001331	003001331	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4543
# text = Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.
1	Low	low	ADV	RB	Degree=Pos	_	_	_	_
2	CD3+CD28-induced	CD3+CD28-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
11	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
12	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4544
# text = The capacity of neonatal T cells to secrete interleukin-2 (IL-2) has been reported to be variable.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	secrete	secrete	VERB	VB	VerbForm=Inf	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4545
# text = We analysed IL-2 production in purified neonatal and adult T cells using polyclonal activator phorbol ester + calcium ionophore (PDBu + iono) or receptor-mediated anti-CD3/anti-CD3+ anti-CD28 stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analysed	analyse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
9	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
19	+	+	SYM	SYM	_	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
21	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	PDBu	PDBu	NOUN	NN	Number=Sing	_	_	_	_
24	+	+	SYM	SYM	_	_	_	_	_
25	iono	iono	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	receptor-	receptor-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	anti-CD3/anti-CD3	anti-CD3/anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	+	+	SYM	SYM	_	_	_	_	_
32	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4546
# text = PDBu + iono induced equally high IL-2 levels in both groups and, when stimulated with plate-bound anti-CD3 monoclonal antibody (mAb), the IL-2 secretion by neonatal cells was undetectable and adult cells produced low amounts of IL-2 (mean 331 +/- 86 pg/ml).
1	PDBu	PDBu	PROPN	NNP	Number=Sing	_	_	_	_
2	+	+	SYM	SYM	_	_	_	_	_
3	iono	iono	ADV	RB	_	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	equally	equally	ADV	RB	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	plate	plate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
23	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
44	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	2	2	NUM	CD	NumType=Card	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	mean	mean	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
51	331	331	NUM	CD	NumType=Card	_	_	_	_
52	+/-	+/-	SYM	SYM	_	_	_	_	_
53	86	86	NUM	CD	NumType=Card	_	_	_	_
54	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4547
# text = The addition of anti-CD28 mAb to anti-CD3-stimulated cells markedly increased IL-2 production in both cell types, but levels of IL-2 in neonatal T cells remained clearly lower than those of adult T cells (respective mean values: 385 +/- 109 pg/ml and 4494 +/- 1199 pg/ml).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-stimulated	-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	markedly	markedly	ADV	RB	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	T	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	clearly	clearly	ADV	RB	_	_	_	_	_
33	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
34	than	than	ADP	IN	_	_	_	_	_
35	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
42	mean	mean	NOUN	NN	Number=Sing	_	_	_	_
43	values	value	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	:	:	PUNCT	:	_	_	_	_	_
45	385	385	NUM	CD	NumType=Card	_	_	_	_
46	+/-	+/-	SYM	SYM	_	_	_	_	_
47	109	109	NUM	CD	NumType=Card	_	_	_	_
48	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	4494	4494	NUM	CD	NumType=Card	_	_	_	_
51	+/-	+/-	SYM	SYM	_	_	_	_	_
52	1199	1199	NUM	CD	NumType=Card	_	_	_	_
53	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4548
# text = As NF-kappa B is a critical transcription factor in the control of IL-2 expression, we next analysed its nuclear translocation in neonatal and adult T cells using the electrophoretic mobility shift assay and, because induction of reactive oxygen intermediates (ROI) is required for the activation of NF-kappa B, we also analysed levels of intracellular ROI in these cells using the ROI-reactive fluorochrome DCFH-DA and flow cytometry.
1	As	as	ADP	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	next	next	ADV	RB	_	_	_	_	_
22	analysed	analyse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
35	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
36	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
37	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	because	because	SCONJ	IN	_	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
44	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
45	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
58	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
61	also	also	ADV	RB	_	_	_	_	_
62	analysed	analyse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
63	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
66	ROI	ROI	NOUN	NNS	Number=Plur	_	_	_	_
67	in	in	ADP	IN	_	_	_	_	_
68	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
70	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
71	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
72	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
74	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
75	fluorochrome	fluorochrome	NOUN	NN	Number=Sing	_	_	_	_
76	DCFH	DCFh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	DA	da	NOUN	NN	Number=Sing	_	_	_	_
79	and	and	CCONJ	CC	_	_	_	_	_
80	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
81	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4549
# text = In neonatal T cells NF-kappa B activation and ROI formation after anti-CD3 stimulation were low compared with adult T cells and, although addition of anti-CD28 mAb increased induction of NF-kappa B and ROI formation, levels similar to those of adults were not achieved.
1	In	in	ADP	IN	_	_	_	_	_
2	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	_
12	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	although	although	SCONJ	IN	_	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
29	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
30	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	ROI	Roi	PROPN	NNP	Number=Sing	_	_	_	_
39	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	adults	adult	NOUN	NNS	Number=Plur	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4550
# text = After PDBu + iono stimulation, the cells showed similar ROI formation and IL-2 secretion.
1	After	after	SCONJ	IN	_	_	_	_	_
2	PDBu	PDBu	PROPN	NNP	Number=Sing	_	_	_	_
3	+	+	SYM	SYM	_	_	_	_	_
4	iono	iono	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	_
12	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4551
# text = Our results suggest that reduced IL-2 production by neonatal T cells is specific for anti-CD3 and anti-CD3+ anti-CD28-mediated stimulation and that these activators cannot effectively activate the ROI-NF-kappa B signalling pathway in neonatal T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
29	not	not	PART	RB	_	_	_	_	_
30	effectively	effectively	ADV	RB	_	_	_	_	_
31	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
40	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4552
# text = Document 003001332 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001332	003001332	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4553
# text = Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells.
1	Aspirin	aspirin	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	stimulated	stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4554
# text = BACKGROUND: The induction of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin by tumor necrosis factor-alpha (TNF) is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B).
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	E-	E-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4555
# text = Since salicylates have been reported to inhibit NF-kappa B activation by preventing the degradation of its inhibitor
1	Since	since	SCONJ	IN	_	_	_	_	_
2	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4556
# text = I kappa B, we studied a potential inhibition of this pathway by acetylsalicylate (aspirin) in human umbilical vein endothelial cells (HUVECs).
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	acetylsalicylate	acetylsalicylate	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
21	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4557
# text = METHODS AND RESULTS: Gel-shift analyses demonstrated dose-dependent inhibition of TNF-induced NF-kappa B mobilization by aspirin at concentrations ranging from 1 to 10 mmol/L.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Gel-	Gel-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	shift	shift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
26	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	10	10	NUM	CD	NumType=Card	_	_	_	_
31	mmol/	mmol/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
32	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4558
# text = Induction of VCAM-1 and E-selectin surface expression by TNF was dose-dependently reduced by aspirin over the same range, while induction of intercellular adhesion molecule-1 (ICAM-1) was hardly affected.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	dependently	dependently	ADV	RB	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
20	over	over	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
23	range	range	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	while	while	SCONJ	IN	_	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
30	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	X	LS	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	hardly	hardly	ADV	RB	_	_	_	_	_
40	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4559
# text = Aspirin appeared to prevent VCAM-1 transcription, since it dose-dependently inhibited induction of VCAM-1 mRNA by TNF.
1	Aspirin	aspirin	PROPN	NNP	Number=Sing	_	_	_	_
2	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
5	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	since	since	SCONJ	IN	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	dose	dose	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependently	dependently	ADV	RB	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4560
# text = As a functional consequence, adhesion of U937 monocytes to TNF-stimulated HUVECs was markedly reduced by aspirin due to suppression of VCAM-1 and E-selectin upregulation.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
20	due	due	ADP	IN	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	VCAM	VCAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
30	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4561
# text = These effects of aspirin were not related to the inhibition of cyclooxygenase activity, since indomethacin was ineffective.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	since	since	SCONJ	IN	_	_	_	_	_
16	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4562
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4563
# text = Our data suggest that aspirin inhibits NF-kappa B mobilization, induction of VCAM-1 and E-selectin, and subsequent monocyte adhesion in endothelial cells stimulated by TNF, thereby providing an additional mechanism for therapeutic effects of aspirin.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	VCAM	VCAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	thereby	thereby	ADV	RB	_	_	_	_	_
33	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
36	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
39	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4564
# text = Document 003001333 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001333	003001333	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4565
# text = T-cell functional regions of the human IL-3 proximal promoter.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4566
# text = The human interleukin-3 (IL-3) gene is expressed almost exclusively in activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	almost	almost	ADV	RB	_	_	_	_	_
15	exclusively	exclusively	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4567
# text = Its expression is regulated at both the transcriptional and post-transcriptional level.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	post	post	X	AFX	_	_	_	_	SpaceAfter=No
11	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4568
# text = We have previously shown that treatment of Jurkat T cells with phytohemaglutinin (PHA) and the phorbol ester, PMA, activated transcription initiation from the IL-3 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	phytohemaglutinin	phytohemaglutinin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4569
# text = To define the regions of the gene required for transcription activation, we generated a series of reporter constructs containing different regions of the IL-3 gene 5' and 3' flanking sequences.
1	To	to	PART	TO	_	_	_	_	_
2	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	series	series	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	'	'	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	PUNCT	``	_	_	_	_	_
34	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4570
# text = Both positive and negative regulatory elements were identified in the proximal 5' flanking region of the IL-3 gene.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4571
# text = The promoter region between -173 and -60 contained the strongest activating elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	173	173	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	strongest	strongest	ADJ	JJS	Degree=Sup	_	_	_	_
13	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4572
# text = The transcription factor AP-1 could bind to this positive activator region of the promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4573
# text = We also examined the function of the IL-3 CK-1/CK-2 elements that are present in many cytokine genes and found that they acted as a repressor of basal level expression when cloned upstream of a heterologous promoter but were also inducible by PMA/PHA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1/CK	-1/ck	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
27	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	when	when	ADV	WRB	PronType=Int	_	_	_	_
36	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	but	but	CCONJ	CC	_	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	also	also	ADV	RB	_	_	_	_	_
45	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	PHA.	PHA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4574
# text = Document 003001334 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001334	003001334	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4575
# text = Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.
1	Negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
19	plus	plus	CCONJ	CC	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4576
# text = Although monocytic cells can provide a reservoir for viral production in vivo, their regulation of human immunodeficiency virus type 1 (HIV-1) transcription can be either latent, restricted, or productive.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	either	either	ADV	RB	_	_	_	_	_
31	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4577
# text = These differences in gene expression have not been molecularly defined.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	molecularly	molecularly	ADV	RB	_	_	_	_	_
10	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4578
# text = In THP-1 cells with restricted HIV expression, there is an absence of DNA-protein binding complex formation with the HIV-1 promoter-enhancer associated with markedly less viral RNA production.
1	In	in	ADP	IN	_	_	_	_	_
2	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	there	there	PRON	EX	_	_	_	_	_
12	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
21	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	markedly	markedly	ADV	RB	_	_	_	_	_
33	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4579
# text = This absence of binding was localized to the NF-kappa B region of the HIV-1 enhancer; the 65-kDa plus 50-kDa NF-kappa B heterodimer was preferentially lost.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
25	plus	plus	CCONJ	CC	_	_	_	_	_
26	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	preferentially	preferentially	ADV	RB	_	_	_	_	_
36	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4580
# text = Adding purified NF-kappa B protein to nuclear extracts from cells with restricted expression overcomes this lack of binding.
1	Adding	add	AUX	VBG	VerbForm=Ger	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	overcomes	overcome	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4581
# text = In addition, treatment of these nuclear extracts with sodium deoxycholate restored their ability to form the heterodimer, suggesting the presence of an inhibitor of NF-kappa B activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
11	deoxycholate	deoxycholate	NOUN	NN	Number=Sing	_	_	_	_
12	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4582
# text = Furthermore, treatment of nuclear extracts from these cells that had restricted expression with lipopolysaccharide increased viral production and NF-kappa B activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4583
# text = Antiserum specific for NF-kappa B binding proteins, but not c-rel-specific antiserum, disrupted heterodimer complex formation.
1	Antiserum	Antiserum	PROPN	NNP	Number=Sing	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	rel-specific	rel-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4584
# text = Thus, both NF-kappa B-binding complexes are needed for optimal viral transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4585
# text = Binding of the 65-kDa plus 50-kDa heterodimer to the HIV-1 enhancer can be negatively regulated in monocytes, providing one mechanism restricting HIV-1 gene expression.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
7	plus	plus	CCONJ	CC	_	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	negatively	negatively	ADV	RB	_	_	_	_	_
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	providing	provid	VERB	VBG	VerbForm=Ger	_	_	_	_
26	one	one	NUM	CD	NumType=Card	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
28	restricting	restrict	VERB	VBG	VerbForm=Ger	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4586
# text = Document 003001335 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001335	003001335	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4587
# text = Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter.
1	Cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
27	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4588
# text = Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
14	CH	Ch	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4589
# text = Subsequently, such primed cells can undergo switch recombination to express the selected new isotype.
1	Subsequently	subsequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
4	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	undergo	undergo	ADV	RB	_	_	_	_	_
8	switch	switch	VERB	VB	VerbForm=Inf	_	_	_	_
9	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
15	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4590
# text = In the case of IgE class switching, IL-4 activates the IgE germline promoter by inducing the interaction of the transcription factor STAT6 (IL-4STAT) with a responsive DNA element in the proximal region of the promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	case	case	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
15	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	ADV	RB	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4STAT	4stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4591
# text = This study describes the characterization of two additional cis-acting elements that interact with members of the NF kappa B/rel transcription factor family in an IL-4-independent fashion.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	members	member	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
33	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4592
# text = Electrophoretic mobility shift assays show that the nucleoprotein complex formed on the upstream site (NF kappa B1) contains the classical p50/p65 heterodimer.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B1	B1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	p65	p65	NUM	CD	NumType=Card	_	_	_	_
26	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4593
# text = The complex on the proximal site (NF kappa B2) appears to be composed of p50 and relB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B2	b2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	relB	relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4594
# text = IgE germline promoter reporter gene constructs carrying point mutations in the NF kappa B2 site were largely unresponsive to IL-4 stimulation in transient transfection experiments, while plasmids with similar mutations in the NF kappa B1 site responded to cytokine stimulation better than the wild-type promoter.
1	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
2	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
8	point	point	NOUN	NN	Number=Sing	_	_	_	_
9	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B2	B2	NUM	CD	NumType=Card	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	largely	largely	ADV	RB	_	_	_	_	_
18	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
26	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
27	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
33	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	_
40	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
43	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
44	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	type	type	NOUN	NN	Number=Sing	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4595
# text = The NF kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4596
# text = B2 effect was dependent on the presence of the STAT6 binding site, demonstrating that the NF kappa B2 motif is necessary but not sufficient for mediating cytokine up-regulation.
1	B2	B2	NUM	CD	NumType=Card	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B2	b2	NUM	CD	NumType=Card	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	cytokine	cytokine	PRON	PRP	_	_	_	_	_
29	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4597
# text = In addition, the combination of a NF kappa B/rel binding site and the STAT6 response element conferred IL-4 inducibility to a heterologous minimal promoter, while the individual sites had no effect.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	rel	rel	X	FW	Foreign=Yes	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
28	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	while	while	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	no	no	DET	DT	_	_	_	_	_
37	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4598
# text = The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA-bound STAT6 to achieve IL-4-dependent activation of the human IgE germline gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B2	B2	NUM	CD	NumType=Card	_	_	_	_
10	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
18	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	achieve	achieve	VERB	VB	VerbForm=Inf	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
31	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4599
# text = Document 003001336 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001336	003001336	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4600
# text = Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	interleukin	interleukin	ADV	RB	_	_	_	_	_
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
14	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4601
# text = Interferons (IFNs) inhibit induction by IL-4 of multiple genes in human monocytes.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IFNs	IFNs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4602
# text = However, the mechanism by which IFNs mediate this inhibition has not been defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	_
8	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4603
# text = IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6 (signal transducer and activator of transcription-6).
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
5	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	homodimerization	homodimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	STAT6	Stat6	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4604
# text = STAT6-responsive elements are characteristically present in the promoters of IL-4-inducible genes.
1	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-responsive	-responsive	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	characteristically	characteristically	ADV	RB	_	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4605
# text = Because STAT6 activation is essential for IL-4-induced gene expression, we examined the ability of type I and type II IFNs to regulate activation of STAT6 by IL-4 in primary human monocytes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4606
# text = Pretreatment of monocytes with IFN-beta or IFN-gamma, but not IL-1, IL-2, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor, IL-6, or transforming growth factor beta suppressed activation of STAT6 by IL-4.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
32	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
43	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
46	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4607
# text = This inhibition was associated with decreased tyrosine phosphorylation and nuclear translocation of STAT6 and was not evident unless the cells were preincubated with IFN for at least 1 hr before IL-4 stimulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
18	unless	unless	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	at	at	ADV	RB	_	_	_	_	_
27	least	least	ADV	RBS	Degree=Sup	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
30	before	before	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4608
# text = Furthermore, inhibition by IFN could be blocked by cotreatment with actinomycin D and correlated temporally with induction of the JAK/STAT inhibitory gene, SOCS-1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing|Typo=Yes	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cotreatment	cotreatment	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	_
13	D	d	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	temporally	temporally	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
24	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	SOCS	SOCS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4609
# text = Forced expression of SOCS-1 in a macrophage cell line, RAW264, markedly suppressed trans-activation of an IL-4-inducible reporter as well as IL-6- and IFN-gamma-induced reporter gene activity.
1	Forced	forced	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	RAW264	RAW264	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-gamma	-gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4610
# text = These findings demonstrate that IFNs inhibit IL-4-induced activation of STAT6 and STAT6-dependent gene expression, at least in part, by inducing expression of SOCS-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	_
6	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT6	Stat6	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	STAT6	Stat6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	at	at	ADV	RB	_	_	_	_	_
22	least	least	ADV	RBS	Degree=Sup	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	by	by	SCONJ	IN	_	_	_	_	_
27	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4611
# text = Document 003001337 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001337	003001337	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4612
# text = Protein kinase C is not a downstream effector of p21ras in activated T cells.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4613
# text = The aim of this present study was to investigate the role of protein kinase C (PKC), downstream of p21ras, in activating interleukin-2 (IL-2) gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	in	in	SCONJ	IN	_	_	_	_	_
25	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4614
# text = It has been reported that PKC is an effector of p21ras in T cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4615
# text = Data is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
10	PKC	Pkc	PROPN	NNP	Number=Sing	_	_	_	_
11	inhibitor	inhibitor	ADP	IN	_	_	_	_	_
12	Ro	Ro	PROPN	NNP	Number=Sing	_	_	_	_
13	31-	31-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	8425	8425	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	constitutively	constitutively	ADV	RB	_	_	_	_	_
21	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
22	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
23	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	clearly	clearly	ADV	RB	_	_	_	_	_
27	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	2	2	NUM	CD	NumType=Card	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
58	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
59	T	t	PROPN	NNP	Number=Sing	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4616
# text = Reporter gene experiments demonstrated that NF-kappa B transcriptional activity is not affected by expression of activated p21ras.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4617
# text = The signaling pathways involving PKC activation, calcium mobilization and ras activation combine to provide the necessary components for production of IL-2 during T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
5	PKC	Pkc	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
9	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ras	ras	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	combine	combine	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
18	components	component	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	T	t	NUM	CD	NumType=Card	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4618
# text = Document 003001338 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001338	003001338	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4619
# text = Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.
1	Non-steroidal	Non-steroidal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
11	HSP70	HSP70	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4620
# text = Recent studies have shown that the non-steroidal anti-inflammatory drugs (NSAIDs) activate heat shock transcription factor (HSF1) from a latent cytoplasmic form to a nuclear, DNA binding state.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	non-steroidal	non-steroidal	ADJ	JJ	Degree=Pos	_	_	_	_
8	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
14	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HSF1	Hsf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4621
# text = As HSF1 can function as both an activator of heat shock genes and a repressor of non-heat shock genes such as IL1B and c- fos, we have examined the potential role of HSF1 in the effects of NSAIDs on gene expression in a human monocytic cell line THP-1.
1	As	as	SCONJ	IN	_	_	_	_	_
2	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	non	non	X	AFX	_	_	_	_	SpaceAfter=No
18	-heat	-heat	ADJ	JJ	Degree=Pos	_	_	_	_
19	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	IL1B	Il1b	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	_
27	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	HSF1	HSF1	NUM	CD	NumType=Card	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	line	line	NOUN	NN	Number=Sing	_	_	_	_
51	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4622
# text = We found that two members of the NSAIDs, sodium salicylate and sulindac repress the IL1B promoter to similar degree to heat shock or HSF1 overexpression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	members	member	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NSAIDs	Nsaids	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	sodium	sodium	ADJ	JJ	Degree=Pos	_	_	_	_
11	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	sulindac	sulindac	NOUN	NN	Number=Sing	_	_	_	_
14	repress	repress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL1B	Il1b	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
20	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
23	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	HSF1	Hsf1	NUM	CD	NumType=Card	_	_	_	_
26	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4623
# text = In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
8	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	activate	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
55	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4624
# text = At least in the case of the IL1B promoter, repression did not seem to involve another factor whose activity is affected by the NSAIDs, NFkappaB as the IL1B promoter fragment used in our studies is not NFkappaB responsive and binds specifically to HSF1.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	case	case	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL1B	IL1B	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	seem	seem	VERB	VB	VerbForm=Inf	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
17	another	another	DET	DT	_	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NSAIDs	Nsaids	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL1B	Il1b	PROPN	NNP	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
33	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
36	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
40	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
43	specifically	specifically	ADV	RB	_	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4625
# text = Exposure to NSAIDs had a complex effect on HSP gene expression and while sulindac activated the stress responsive HSP70B promoter, sodium salicylate did not.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	NSAIDs	Nsaids	PROPN	NNP	Number=Sing	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	HSP	Hsp	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	while	while	SCONJ	IN	_	_	_	_	_
14	sulindac	sulindac	NOUN	NN	Number=Sing	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
18	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	HSP70B	Hsp70b	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
23	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
24	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4626
# text = In addition, only a subset of the NSAIDs induced HSP70 mRNA species.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NSAIDs	Nsaids	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	HSP70	HSP70	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4627
# text = These findings reflect the properties of HSF1 which can be activated to at least two DNA binding forms only one of which activates heat shock promoters and suggest that individual NSAID family members may differentially induce one or other of these forms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	reflect	reflect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	at	at	ADV	RB	_	_	_	_	_
14	least	least	ADV	RBS	Degree=Sup	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
25	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
31	NSAID	nsaid	NOUN	NN	Number=Sing	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	members	member	NOUN	NNS	Number=Plur	_	_	_	_
34	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
35	differentially	differentially	ADV	RB	_	_	_	_	_
36	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
37	one	one	NUM	CD	NumType=Card	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4628
# text = Overall therefore, exposure to NSAIDs leads to a profound switch in gene expression in monocytic cells, with suppression of genes involved in macrophage activation and induction of stress genes and HSF1 appears to play a regulatory role in these effects.
1	Overall	overall	ADV	RB	_	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	exposure	exposure	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	NSAIDs	NSAid	PROPN	NNP	Number=Sing	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
11	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	HSF1	Hsf1	NOUN	NN	Number=Sing	_	_	_	_
34	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4629
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4630
# text = Document 003001339 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001339	003001339	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4631
# text = Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
12	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
22	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4632
# text = Human C/EBP epsilon is a newly cloned gene coding for a CCAAT/enhancer binding protein that may be involved in the regulation of myeloid differentiation.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
4	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
5	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	newly	newly	ADV	RB	_	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	coding	cod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4633
# text = Our studies showed that levels of C/EBP epsilon mRNA were markedly increased in NB4 cells (promyelocytic leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards granulocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
10	epsilon	epsilon	ADP	IN	_	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	markedly	markedly	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	because	because	SCONJ	IN	_	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
32	retinoic	retinoic	NOUN	NN	Number=Sing	_	_	_	_
33	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
38	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
42	towards	towards	ADP	IN	_	_	_	_	_
43	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4634
# text = Accumulation of C/EBP epsilon mRNA occurred as early as 1 hour after exposure of NB4 cells to 9-cis RA (5 x 10(-7) mol/L); and at 48 hours, levels were increased by 5.1-fold.
1	Accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
6	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	as	as	ADV	RB	_	_	_	_	_
10	early	early	ADV	RB	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
23	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	x	x	SYM	SYM	_	_	_	_	_
27	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
29	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	48	48	NUM	CD	NumType=Card	_	_	_	_
37	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	5.1	5.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4635
# text = Dose-response studies showed that 10(-7) to 10(-6) mol/L 9-cis RA (12 hours) resulted in peak levels of C/EBP epsilon mRNA; but even 10(-10) mol/L 9-cis RA increased levels of these transcripts.
1	Dose	Dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
9	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
17	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
20	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	12	12	NUM	CD	NumType=Card	_	_	_	_
23	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
33	epsilon	epsilon	ADP	IN	_	_	_	_	_
34	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	even	even	ADV	RB	_	_	_	_	_
38	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
40	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
43	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
46	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
47	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
51	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4636
# text = NB4 cells pulse-exposed (30 minutes) to all-trans retinoic acid (ATRA), washed, and cultured (3 days) with either dimethylsulfoxide (DMSO) or hexamethylene bisacetamide (HMBA) had a prominent increase in levels of C/EBP epsilon mRNA and an increase in granulocytic differentiation, but exposure to either DMSO or HMBA alone had no effect on base levels of C/EBP epsilon and did not induce differentiation.
1	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	pulse	pulse	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	exposed	exposed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	30	30	NUM	CD	NumType=Card	_	_	_	_
8	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	trans	tran	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	washed	wash	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	either	either	CCONJ	CC	_	_	_	_	_
30	dimethylsulfoxide	dimethylsulfoxide	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	hexamethylene	hexamethylene	NOUN	NN	Number=Sing	_	_	_	_
36	bisacetamide	bisacetamide	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	HMBA	HMBA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
43	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
50	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
51	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
57	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	but	but	CCONJ	CC	_	_	_	_	_
60	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
61	to	to	ADP	IN	_	_	_	_	_
62	either	either	CCONJ	CC	_	_	_	_	_
63	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	_
64	or	or	CCONJ	CC	_	_	_	_	_
65	HMBA	HMBA	PROPN	NNP	Number=Sing	_	_	_	_
66	alone	alone	ADV	RB	_	_	_	_	_
67	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
68	no	no	DET	DT	_	_	_	_	_
69	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
70	on	on	ADP	IN	_	_	_	_	_
71	base	base	NOUN	NN	Number=Sing	_	_	_	_
72	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
76	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
77	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
78	and	and	CCONJ	CC	_	_	_	_	_
79	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
80	not	not	PART	RB	_	_	_	_	_
81	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
82	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4637
# text = Macrophage-differentiation of NB4 reduced levels of C/EBP epsilon mRNA.
1	Macrophage	Macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
12	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4638
# text = Nuclear run-off assays and half-life studies showed that accumulation of C/EBP epsilon mRNA by 9-cis RA was due to enhanced transcription.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-off	-off	ADJ	JJ	Degree=Pos	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	life	life	NOUN	NN	Number=Sing	_	_	_	_
9	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
17	epsilon	epsilon	ADP	IN	_	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
22	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
23	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4639
# text = Furthermore, this C/EBP epsilon mRNA accumulation did not require synthesis of new protein factors because 9-cis RA induced C/EBP epsilon mRNA accumulation in the absence of new protein synthesis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
10	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
22	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	C/	Cith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
25	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
26	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
27	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
28	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4640
# text = ATRA also induced expression of C/EBP epsilon protein in NB4 cells, as shown by Western blotting.
1	ATRA	ATRA	ADV	RB	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
9	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
19	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4641
# text = In contrast to the increase of C/EBP epsilon in 9-cis RA-mediated granulocytic differentiation, the DMSO-induced differentiation of HL-60 cells down the granulocytic pathway was associated with an initial reduction of C/EBP epsilon mRNA levels.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
10	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
15	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	60	60	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	down	down	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
40	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
45	epsilon	epsilon	ADP	IN	_	_	_	_	_
46	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
47	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4642
# text = In summary, we have discovered that expression of C/EBP epsilon mRNA is markedly enhanced as the NB4 promyelocytes are induced by retinoids to differentiate towards granulocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
13	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NB4	Nb4	NOUN	NN	Number=Sing	_	_	_	_
21	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
28	towards	towards	ADP	IN	_	_	_	_	_
29	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4643
# text = This induction of C/EBP epsilon mRNA expression is transcriptionally mediated and occurs in the absence of synthesis of additional protein factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4644
# text = We suspect that the C/EBP epsilon promoter/enhancer contains a retinoic acid-response element that is directly stimulated by retinoids.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suspect	suspect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	_
7	epsilon	epsilon	ADP	IN	_	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	directly	directly	ADV	RB	_	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4645
# text = Document 003001340 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001340	003001340	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4646
# text = Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
1	Ubiquitin-	Ubiquitin-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
11	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
12	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4647
# text = Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
1	Reconstitution	Reconstitution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ubiquitin-	ubiquitin-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	carrier	carrier	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
21	ubiquitin-	ubiquitin-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4648
# text = In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family.
1	In	in	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
15	consisting	consisting	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	p50	p50	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4649
# text = p50 is translated as a precursor of 105 kDa.
1	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	105	105	NUM	CD	NumType=Card	_	_	_	_
9	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4650
# text = The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	rapidly	rapidly	ADV	RB	_	_	_	_	_
10	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4651
# text = The mechanism of generation of p50 is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p50	p50	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4652
# text = It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ubiquitin-	ubiquitin-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
21	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
27	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	half	half	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	spared	spare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	obscure	obscure	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4653
# text = Palombella and colleagues (Palombella, V.J., Rando, O.J., Goldberg, A.L., and Maniatis, T.(1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
1	Palombella	Palombella	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	colleagues	colleague	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Palombella	Palombella	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	V.J.	V.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Rando	Rando	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	O.J.	O.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Goldberg	Goldberg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	A.L.	A.L.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Maniatis	Maniatis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T.	T.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	1994	1994	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	78	78	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	773-785	773-785	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	ubiquitin	ubiquitin	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
43	system	system	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	truncated	truncated	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	artificially	artificially	ADV	RB	_	_	_	_	_
49	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
54	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4654
# text = They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	proteasome	proteasome	DET	DT	_	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4655
# text = In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
13	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
14	system	system	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	directly	directly	ADV	RB	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	a	a	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	ubiquitin-	ubiquitin-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
26	system	system	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
35	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	b	b	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	ubiquitin	ubiquitin	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
46	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
49	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
50	step	step	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	processing	processing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	c	c	X	LS	_	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	recently	recently	ADV	RB	_	_	_	_	_
60	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
62	species	species	NOUN	NNS	Number=Plur	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	ubiquitin-	ubiquitin-	SYM	NFP	_	_	_	_	SpaceAfter=No
66	carrier	carrier	NOUN	NN	Number=Sing	_	_	_	_
67	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	E2-	e2-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	F1	F1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	_
72	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
73	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
74	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
75	in	in	ADP	IN	_	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
78	and	and	CCONJ	CC	_	_	_	_	_
79	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
80	of	of	ADP	IN	_	_	_	_	_
81	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
84	also	also	ADV	RB	_	_	_	_	_
85	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
86	for	for	ADP	IN	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
89	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
90	of	of	ADP	IN	_	_	_	_	_
91	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
92	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
93	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
94	,	,	PUNCT	,	_	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
97	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
98	)	)	PUNCT	-RRB-	_	_	_	_	_
99	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
100	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
101	,	,	PUNCT	,	_	_	_	_	_
102	approximately	approximately	ADV	RB	_	_	_	_	_
103	320	320	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
104	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
105	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
106	species	species	NOUN	NNS	Number=Plur	_	_	_	_
107	of	of	ADP	IN	_	_	_	_	_
108	ubiquitin-protein	ubiquitin-protein	ADJ	JJ	Degree=Pos	_	_	_	_
109	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
110	,	,	PUNCT	,	_	_	_	_	_
111	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
112	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
113	in	in	ADP	IN	_	_	_	_	_
114	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
115	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
116	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4656
# text = This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	E6	e6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-conjugating	-conjugat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
23	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	end	end	NOUN	NN	Number=Sing	_	_	_	_
26	rule	rule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	"	"	PUNCT	''	_	_	_	_	_
28	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4657
# text = Document 003001341 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001341	003001341	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4658
# text = The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
3	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	females	female	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
8	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
9	X	x	SYM	SYM	_	_	_	_	_
10	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	undergo	undergo	VERB	VB	VerbForm=Inf	_	_	_	_
20	X	x	ADP	IN	_	_	_	_	_
21	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4659
# text = Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype.
1	Mental	mental	ADJ	JJ	Degree=Pos	_	_	_	_
2	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	constellation	constellation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	congenital	congenital	ADJ	JJ	Degree=Pos	_	_	_	_
8	malformations	malformation	NOUN	NNS	Number=Plur	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	usually	usually	ADV	RB	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Turner	Turner	NOUN	NN	Number=Sing	_	_	_	_
14	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	females	female	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mosaic	mosaic	NOUN	NN	Number=Sing	_	_	_	_
23	45,X	45,X	ADP	IN	_	_	_	_	SpaceAfter=No
24	/46,X	/46,X	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,r	,r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	X	x	SYM	SYM	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	karyotype	karyotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4660
# text = Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	females	female	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	XIST	Xist	NOUN	NN	Number=Sing	_	_	_	_
9	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
13	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
14	X	x	SYM	SYM	_	_	_	_	_
15	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	either	either	ADV	RB	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4661
# text = As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active.
1	As	as	ADP	IN	_	_	_	_	_
2	XIST	Xist	ADJ	JJS	Degree=Sup	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	X	x	PROPN	NNP	Number=Sing	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
15	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	spermatogonia	spermatogonia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	nonexpression	nonexpression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
27	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
29	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
35	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4662
# text = We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ring	re	NOUN	NN	Number=Sing	_	_	_	_
8	X	X	SYM	SYM	_	_	_	_	_
9	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
10	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
11	XIST	Xist	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	XISTE	Xiste	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	three	three	NUM	CD	NumType=Card	_	_	_	_
20	females	female	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
23	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4663
# text = The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
4	ring	re	NOUN	NN	Number=Sing	_	_	_	_
5	X	x	SYM	SYM	_	_	_	_	_
6	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
7	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	acetylated	acetylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
18	H4	H4	NOUN	NN	Number=Sing	_	_	_	_
19	marking	marking	NOUN	NN	Number=Sing	_	_	_	_
20	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	level	level	NOUN	NN	Number=Sing	_	_	_	_
28	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
32	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4664
# text = We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	tow	tow	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	XISTE	XISTE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	ring	re	NOUN	NN	Number=Sing	_	_	_	_
10	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
13	whether	whether	SCONJ	IN	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	normally	normally	ADV	RB	_	_	_	_	_
18	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	X	x	NOUN	NN	Number=Sing	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4665
# text = Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hybrid	hybrid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	TIMP	TIMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	ZXDA	ZXDA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ZXDB	ZXDB	PROPN	NNP	Number=Sing	_	_	_	_
13	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
18	arm	arm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	AR	be	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	PHKA1	PHKA1	NUM	CD	NumType=Card	_	_	_	_
24	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	arm	arm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
36	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
37	X	x	SYM	SYM	_	_	_	_	_
38	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
39	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
40	XIST	Xist	ADJ	JJ	Degree=Pos	_	_	_	_
41	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4666
# text = Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
5	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	XIST	Xist	NOUN	NN	Number=Sing	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	transcribe	transcribe	VERB	VB	VerbForm=Inf	_	_	_	_
14	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	AR	ar	NOUN	NN	Number=Sing	_	_	_	_
19	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	along	along	ADP	IN	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	one	one	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	X	x	NOUN	NN	Number=Sing	_	_	_	_
30	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4667
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4668
# text = Document 003001342 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001342	003001342	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4669
# text = Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4670
# text = The Th2-type cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), induce expression of a distinct subset of genes in human monocytes, including FcepsilonRIIb (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and type I and type II IL-1 receptors (IL-1R).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-type	-type	NOUN	NN	Number=Sing	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-13	-13	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	induce	induce	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
28	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
36	FcepsilonRIIb	FcepsilonRIIb	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD23	CD23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
49	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1ra	1ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	type	type	NOUN	NN	Number=Sing	_	_	_	_
58	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
61	II	ii	NUM	CD	NumType=Card	_	_	_	_
62	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
64	1	1	NUM	CD	NumType=Card	_	_	_	_
65	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	1R	1r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4671
# text = Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) inhibit induction of these genes by IL-4 and IL-13.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	type	type	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4672
# text = However, the mechanism by which IFNs mediate this inhibition has not been defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	_
8	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4673
# text = In this overview, we discuss the role of the transcription factor, STAT6 (signal transducer and activator of transcription-6) in mediating IL-4- and IL-13-induced gene expression in monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	overview	overview	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	in	in	SCONJ	IN	_	_	_	_	_
26	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4674
# text = We also discuss our recent findings that type I and type II IFNs suppress IL-4/IL-13-inducible gene expression by inhibiting tyrosine phosphorylation and nuclear translocation of STAT6.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
6	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
14	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
15	IL-4/IL	Il-4/il	ADP	IN	_	_	_	_	SpaceAfter=No
16	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4675
# text = The ability of type I and type II IFNs to inhibit IL-4/IL-13-induced STAT6 activity is dose- and time-dependent, and is not unique to monocytes because IFNs induce the same effects in fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	IL-4/IL-13	IL-4/IL-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	because	because	SCONJ	IN	_	_	_	_	_
31	IFNs	IFN	PROPN	NNPS	Number=Plur	_	_	_	_
32	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
35	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4676
# text = Inhibition of STAT6 activity is not evident unless cells are preincubated with IFN for at least 1 h before IL-4 stimulation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
8	unless	unless	SCONJ	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	before	before	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4677
# text = Furthermore, inhibition can be blocked by actinomycin D, indicating a requirement for de novo transcription.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	actinomycin	actinomycin	ADP	IN	_	_	_	_	_
9	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	de	de	PROPN	NNP	Number=Sing	_	_	_	_
16	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4678
# text = We propose a model in which stimulation of monocytes by IFN activates de novo synthesis of an inhibitory factor, possibly one or more members of the SOCS/ SSI/CIS gene family, capable of suppressing activation of STAT6 by IL-4 and IL-13.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
12	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
13	de	de	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	possibly	possibly	ADV	RB	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
25	members	member	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	SOCS	SOCS	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	_
30	SSI	SSI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	CIS	CIS	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
37	of	of	SCONJ	IN	_	_	_	_	_
38	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	4	4	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4679
# text = Because STAT6 activation plays an essential role in IL-4/IL-13-induced gene expression, the ability of IFN-beta and IFN-gamma to inhibit STAT6 activity provides an explanation for how IFNs can suppress IL-4/IL-13-inducible gene expression.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IL-4/IL-13	IL-4/IL-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
26	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	SCONJ	IN	_	_	_	_	_
32	how	how	ADV	WRB	PronType=Int	_	_	_	_
33	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
36	IL-4/IL	Il-4/il	ADP	IN	_	_	_	_	SpaceAfter=No
37	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4680
# text = Document 003001343 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001343	003001343	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4681
# text = Positive and negative regulation of IL-2 gene expression: role of multiple regulatory sites.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4682
# text = Interleukin 2 (IL-2) is an important lymphokine required in the process of T cell activation, proliferation, clonal expansion and differentiation.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	process	process	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4683
# text = The IL-2 gene displays both T cell specific and inducible expression: it is only expressed in CD4+ T cells after antigenic or mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	T	t	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4684
# text = Several cis-acting regulatory sites are required for induction of the IL-2 gene after stimulation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4685
# text = In this study, we have analysed the function of these cis-acting regulatory sites in the context of the native IL-2 enhancer and promoter sequence.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	context	context	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4686
# text = The results of this study suggest that the NFAT (-276 to -261), the distal octamer (-256 to -248) and the proximal octamer (-75 to -66) sites not only act as enhancers of IL-2 gene transcription in the presence of cellular stimulation, but also have a silencing effect on IL-2 gene expression in resting cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
10	(-276	(-276	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	261	261	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
18	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	256	256	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	248	248	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
29	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
30	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
31	75	75	NUM	CD	NumType=Card	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	66	66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	not	not	ADV	RB	_	_	_	_	_
38	only	only	ADV	RB	_	_	_	_	_
39	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	as	as	SCONJ	IN	_	_	_	_	_
41	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
53	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	but	but	CCONJ	CC	_	_	_	_	_
56	also	also	ADV	RB	_	_	_	_	_
57	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	silencing	silence	NOUN	NN	Number=Sing	_	_	_	_
60	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
61	on	on	ADP	IN	_	_	_	_	_
62	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	2	2	NUM	CD	NumType=Card	_	_	_	_
65	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
66	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
67	in	in	ADP	IN	_	_	_	_	_
68	resting	rest	ADJ	JJ	Degree=Pos	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4687
# text = Two other sites display disparate effects on IL-2 gene expression in different T leukemia cell lines: the distal purine box (-291 to -277) and the proximal purine box sites (-145 to -128).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	disparate	disparate	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
22	purine	purine	NOUN	NN	Number=Sing	_	_	_	_
23	box	box	NOUN	NN	Number=Sing	_	_	_	_
24	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
25	291	291	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	277	277	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
33	purine	purine	NOUN	NN	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	145	145	NUM	CD	NumType=Card	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	128	128	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4688
# text = Finally, the AP-1 (-186 to -176) and the kappa B sites (-206 to -195) respond to different cellular activation in EL4 cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	-186	-186	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	176	176	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
19	206	206	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	195	195	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4689
# text = The AP-1 site mediated the response to PMA stimulation while the kappa B site responded to IL-1 stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	while	while	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4690
# text = These data suggest that the regulation of IL-2 gene expression is a complex process and multiple cis-acting regulatory sites interact to exert different effects in T cells representative of alternative stages of differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
16	process	process	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	representative	representative	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
35	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4691
# text = Document 003001344 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001344	003001344	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4692
# text = Nuclear transcription factors that bind to elements of the IL-2 promoter.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4693
# text = Induction requirements in primary human T cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4694
# text = Prior studies have identified several elements that contribute to the activity of the IL-2 promoter in the stimulated T cell line, Jurkat.
1	Prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4695
# text = The sites and their corresponding nuclear binding factors include: NF-kappa B, AP-1, AP-3, OCT-1, and NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	corresponding	correspond	NOUN	NN	Number=Sing	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	OCT	Oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4696
# text = The latter "nuclear factor for activated T cells" likely contributes to the tissue specificity of IL-2 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
3	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	"	"	PUNCT	``	_	_	_	_	_
11	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
12	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
16	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4697
# text = Using electrophoretic mobility shift assays, we have studied these transcription factors in primary T cells from human blood to verify their presence in a physiologic setting and to identify the signals that stimulate factor activity.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	verify	verify	VERB	VB	VerbForm=Inf	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
27	setting	set	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4698
# text = All factors are induced in the nuclei of T cells upon activation with mitogens but not with exogenous IL-2 growth factor.
1	All	all	DET	DT	_	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4699
# text = However, the signaling requirements and sensitivity to protein synthesis inhibitors differ considerably.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
10	synthesis	synthesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	considerably	considerably	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4700
# text = Only the activities for NF-AT and AP-1 sites require two signals for optimal induction, i.e., PMA plus either lectin or antibody to the CD3 or CD28 surface molecules.
1	Only	only	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
23	plus	plus	CCONJ	CC	_	_	_	_	_
24	either	either	CCONJ	CC	_	_	_	_	_
25	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4701
# text = Other factors are induced by lectin, antibody, and/or PMA alone.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	antibody	antibody	PRON	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	or	or	CCONJ	CC	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
14	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4702
# text = After appropriate stimulation, both NF-AT and AP-1 are peculiarly sensitive to the protein synthesis inhibitor anisomycin.
1	After	after	ADP	IN	_	_	_	_	_
2	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	peculiarly	peculiarly	ADV	RB	_	_	_	_	_
15	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	anisomycin	anisomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4703
# text = Our data correlate the activity of NF-AT and AP-1 in gel shift assays with the two signals requirements for IL-2 gene expression.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
22	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4704
# text = Document 003001345 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001345	003001345	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4705
# text = Expression of transcription factor genes after influenza A virus infection.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	influenza	influenza	NOUN	NN	Number=Sing	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4706
# text = Infection of human monocytes with influenza
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	influenza	influenza	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4707
# text = A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
6	range	range	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	attracting	attract	VERB	VBG	VerbForm=Ger	_	_	_	_
14	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
15	before	before	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
20	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4708
# text = The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorly understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
11	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	still	still	ADV	RB	_	_	_	_	_
17	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
18	understood	understand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4709
# text = Activation of NF-kappa B seems to play an important role in the regulation of many proinflammatory cytokine genes, but cannot be the only mechanism, since several cytokine genes lack respective binding sites in their promoter regions.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
18	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
24	not	not	PART	RB	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
28	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	since	since	SCONJ	IN	_	_	_	_	_
31	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
34	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
35	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
41	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4710
# text = Therefore, we additionally investigated other transcription factors of possible importance such as CREB, CTF, OTF-1, and OTF-2.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	additionally	additionally	ADV	RB	_	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
11	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CTF	CTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4711
# text = To explore long-term regulatory mechanisms, we investigated the induction of transcription factors on the gene expression level which may be important to substitute for metabolized transcription factor proteins after their activation.
1	To	to	PART	TO	_	_	_	_	_
2	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
3	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	term	term	NOUN	NN	Number=Sing	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	substitute	substitute	VERB	VB	VerbForm=Inf	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	metabolized	metabolize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	after	after	ADP	IN	_	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4712
# text = We identified a cell-type-specific differential response: CREB, CTF, OTF-1, OFT-2, and NF-kappa B genes were strongly induced 1 to 4 hours after influenza
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CTF	CTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	OFT	OFT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	strongly	strongly	ADV	RB	_	_	_	_	_
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	4	4	NUM	CD	NumType=Card	_	_	_	_
36	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
37	after	after	ADP	IN	_	_	_	_	_
38	influenza	influenza	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4713
# text = A virus infection in the monocytic cell line Mono Mac 6, while in freshly prepared human monocytes no significant changes were detected.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
10	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	while	while	SCONJ	IN	_	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	freshly	freshly	ADV	RB	_	_	_	_	_
16	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	no	no	DET	DT	_	_	_	_	_
20	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4714
# text = In infected monocytes, which die by apoptosis, the expression of CREB, CTF, and OTF-2 was rather suppressed 8 hours after infection.
1	In	in	ADP	IN	_	_	_	_	_
2	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	die	die	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	apoptosis	apoptosis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	CTF	CTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	rather	rather	ADV	RB	_	_	_	_	_
23	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	8	8	NUM	CD	NumType=Card	_	_	_	_
25	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4715
# text = In conclusion, the long-term regulation of transcription factor gene expression in non-proliferating cells seems to be of minor importance after influenza infection since in apoptosisprone cells an immediate availability of transcription factor proteins is required.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	term	term	NOUN	NN	Number=Sing	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	non-proliferating	non-proliferat	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
22	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	influenza	influenza	ADJ	JJ	Degree=Pos	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	since	since	SCONJ	IN	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	apoptosisprone	apoptosisprone	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
32	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4716
# text = Document 003001346 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001346	003001346	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4717
# text = Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4718
# text = The E2A gene encodes transcription factors of the helix-loop-helix family that are implicated in cell-specific gene expression as part of dimeric complexes that interact with E box enhancer elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
3	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	part	part	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	dimeric	dimeric	ADJ	JJ	Degree=Pos	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	E	e	NOUN	NN	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4719
# text = It has previously been shown that transcripts of the E2A gene can be detected in a wide range of cell types.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
18	range	range	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4720
# text = We have now examined expression of the mouse E2A gene at the protein level using polyclonal antisera directed against distinct portions of the E2A protein to probe blots of cellular extracts.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	_
19	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	against	against	ADP	IN	_	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	portions	portion	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	probe	probe	VERB	VB	VerbForm=Inf	_	_	_	_
29	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4721
# text = A 73 kDa protein was identified by this analysis: this protein is highly enriched in cell lines of B lymphoid origin as compared to pancreatic beta-cells and fibroblast cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	73	73	NUM	CD	NumType=Card	_	_	_	_
3	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	highly	highly	ADV	RB	_	_	_	_	_
15	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4722
# text = The detection of this protein selectively in extracts of lymphoid cells correlates with the presence of the E box-binding activity LEF1/BCF1 in these cells; this binding activity was previously shown to be efficiently recognized by antiserum directed against E2A gene products.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	selectively	selectively	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	E	e	NOUN	NN	Number=Sing	_	_	_	_
19	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	LEF1/BCF1	Lef1/bcf1	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	previously	previously	ADV	RB	_	_	_	_	_
33	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	efficiently	efficiently	ADV	RB	_	_	_	_	_
37	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
40	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	against	against	ADP	IN	_	_	_	_	_
42	E2A	E2a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
44	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4723
# text = Transfection of cells with full length E2A cDNA leads to appearance of protein co-migrating with the 73 kDa protein on SDS gel electrophoresis and co-migrating with LEF1/BCF1 on mobility shift analysis.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
6	length	length	NOUN	NN	Number=Sing	_	_	_	_
7	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	co-migrating	co-migrat	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	73	73	NUM	CD	NumType=Card	_	_	_	_
19	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	SDS	SDS	NOUN	NN	Number=Sing	_	_	_	_
23	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
24	electrophoresis	electrophoresis	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	co-migrating	co-migrat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	LEF1/BCF1	LEF1/BCF1	PROPN	NNP	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
31	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
32	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4724
# text = Our results are consistent with the view that the DNA-binding activity LEF1/BCF1 is a homodimer of E2A proteins; the selective appearance of this putative cell-specific transcription factor in B lymphoid cells seems to be attributable, at least in part, to the elevated E2A protein concentrations in these cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	view	view	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	LEF1/	Lef1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	BCF1	Bcf1	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
25	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	at	at	ADV	RB	_	_	_	_	_
44	least	least	ADV	RBS	Degree=Sup	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
53	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4725
# text = Document 003001347 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001347	003001347	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4726
# text = Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
3	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4727
# text = Inducible nitric oxide (iNO) is produced at sites of vascular inflammation by resident and nonresident vascular wall cells, but its role in the inflammatory process is not known.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
3	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	iNO	iNO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
13	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	resident	resident	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nonresident	nonresident	ADJ	JJ	Degree=Pos	_	_	_	_
18	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
19	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
24	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	process	process	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4728
# text = In this study, we show that a novel function of iNO is to terminate inflammatory processes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	iNO	iNO	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	terminate	terminate	VERB	VB	VerbForm=Inf	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4729
# text = We find that iNO produced by murine macrophage-like cells, RAW264.7, can inhibit cytokine-induced endothelial cell activation in a separated and mixed endothelial-RAW264.7 coculture system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	iNO	ino	PROPN	NNP	Number=Sing	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	264.7	264.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	RAW264.7	RAW264.7	NOUN	NN	Number=Sing	_	_	_	_
32	coculture	coculture	NOUN	NN	Number=Sing	_	_	_	_
33	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4730
# text = Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma.
1	Both	both	DET	DT	_	_	_	_	_
2	iNO	ino	ADJ	JJ	Degree=Pos	_	_	_	_
3	production	production	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	murine	murine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4731
# text = Inhibition of iNO synthase (iNOS) activity with N omega-monomethyl-L-arginine in endothelial-RAW264.7 cocultures, stimulated with murine-specific IFN-gamma and LPS, decreased iNO production by 86%, augmented VCAM-1 and iNOS expression in endothelial and RAW264.7 cells, respectively, and increased monocyte adhesion to the endothelial cell surface.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	iNO	ino	DET	DT	_	_	_	_	_
4	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	iNOS	iNOS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	N	N	PROPN	NNP	Number=Sing	_	_	_	_
11	omega	omega	X	AFX	_	_	_	_	SpaceAfter=No
12	-monomethyl	-monomethyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	L	l	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-RAW264.7	-RAW264.7	NUM	CD	NumType=Card	_	_	_	_
20	cocultures	coculture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	murine	murine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	iNO	ino	DET	DT	_	_	_	_	_
35	production	production	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	iNOS	inos	ADJ	JJ	Degree=Pos	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	RAW	raw	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
59	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
60	to	to	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
63	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
64	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4732
# text = Transient transfection studies using various VCAM-1 promoter constructs demonstrated that inhibitory effects of iNO on VCAM-1 gene transcription were mediated, in part, by inhibitory effects of iNO on kappa B cis-acting elements.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
14	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	iNO	iNO	PROPN	NNP	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	iNO	iNO	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4733
# text = Immunofluorescence studies using an Ab to the RelA (p65) subunit of nuclear factor-kappa B revealed that iNO inhibited the activation of nuclear factor-kappa B.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	iNO	iNO	PROPN	NNP	Number=Sing	_	_	_	_
22	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4734
# text = These studies indicate that iNO attenuates iNOS expression in macrophages and inhibits monocyte adhesion to endothelial cells, and suggest that endogenously derived iNO may be an important autoregulatory inhibitor of vascular inflammation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	iNO	iNO	X	GW	_	_	_	_	_
6	attenuates	attenuate	X	GW	_	_	_	_	_
7	iNOS	inos	X	GW	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	endogenously	endogenously	ADV	RB	_	_	_	_	_
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	iNO	ino	PROPN	NNP	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
33	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4735
# text = Document 003001348 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001348	003001348	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4736
# text = Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.
1	Evidence	evidence	SCONJ	IN	_	_	_	_	_
2	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	limiting	limiting	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4737
# text = Cyclosporine (CsA) is both a clinical immunosuppressive drug and a probe to dissect intracellular signaling pathways.
1	Cyclosporine	Cyclosporine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	both	both	DET	PDT	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	dissect	dissect	VERB	VB	VerbForm=Inf	_	_	_	_
16	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4738
# text = In vitro, CsA inhibits lymphocyte gene activation by inhibiting the phosphatase activity of calcineurin (CN).
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
6	lymphocyte	lymphocyte	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CN	CN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4739
# text = In clinical use, CsA treatment inhibits 50-75% of CN activity in circulating leukocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	use	use	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CN	Cn	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4740
# text = We modeled this degree of CN inhibition in primary human leukocytes in vitro in order to study the effect of partial CN inhibition on the downstream signaling events that lead to gene activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	modeled	model	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	order	order	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
27	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
28	events	event	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4741
# text = In CsA-treated leukocytes stimulated by calcium ionophore, the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested: dephosphorylation of nuclear factor of activated T cell proteins, nuclear DNA binding, activation of a transfected reporter gene construct, IFN-gamma and IL-2 mRNA accumulation, and IFN-gamma production.
1	In	in	ADP	IN	_	_	_	_	_
2	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
9	ionophore	ionophore	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	CN	CN	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
23	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	event	event	NOUN	NN	Number=Sing	_	_	_	_
29	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
30	:	:	PUNCT	:	_	_	_	_	_
31	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
51	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	2	2	NUM	CD	NumType=Card	_	_	_	_
60	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
61	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
67	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4742
# text = Furthermore, the degree of CN inhibition was reflected by a similar degree of reduction in lymphocyte proliferation and IFN-gamma production in the allogeneic mixed lymphocyte cultures.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	allogeneic	allogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
27	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
29	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4743
# text = These data support the conclusion that CN activity is rate-limiting for the activation of primary human T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CN	Cn	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	limiting	limiting	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	NOUN	NN	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4744
# text = Thus, the reduction of CN activity observed in CsA-treated patients is accompanied by a similar degree of reduction in lymphocyte gene activation, and accounts for the immunosuppression observed.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	CN	PROPN	NNP	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	accounts	account	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
32	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4745
# text = Document 003001349 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001349	003001349	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4746
# text = Identification of upstream regulatory elements that repress expression of adult beta-like globin genes in a primitive erythroid environment.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	repress	repress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4747
# text = Our investigations have focused on localizing cis-elements responsible for the down regulation of the adult beta-like globin genes (delta and beta) in immature, or primitive erythroid tissues.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	investigations	investigation	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	SCONJ	IN	_	_	_	_	_
6	localizing	localizing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	down	down	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4748
# text = We studied their activity after transfection into K562 cells, an erythroleukemia cell line with an embryonic-fetal phenotype.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	K562	K562	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	erythroleukemia	erythroleukemia	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4749
# text = Analyzed DNA sequences included delta and beta 5' flanking regions extending from approximately -500 to +50bp (promoter regions), truncated delta and beta 5' flanking regions extending from approximately -250 to +50 bp, and chimeric promoter constructions, which consisted of a distal delta or beta fragment fused to a proximal beta or delta sequence.
1	Analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
4	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	500	500	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
19	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	truncated	truncated	ADJ	JJ	Degree=Pos	_	_	_	_
27	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
30	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	'	'	PUNCT	``	_	_	_	_	_
32	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
33	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
34	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	approximately	approximately	ADV	RB	_	_	_	_	_
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	250	250	NUM	CD	NumType=Card	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	+50	+50	NUM	CD	NumType=Card	_	_	_	_
41	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
45	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
46	constructions	construction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	which	which	PRON	WDT	PronType=Rel	_	_	_	_
49	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
53	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
54	or	or	CCONJ	CC	_	_	_	_	_
55	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
56	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
57	fused	fuse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
58	to	to	ADP	IN	_	_	_	_	_
59	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
61	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
62	or	or	CCONJ	CC	_	_	_	_	_
63	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
64	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4750
# text = In CAT reporter constructions no appreciable level of CAT activity was supported by the beta globin promoter, and only low level activity by the delta promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
3	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
4	constructions	construction	NOUN	NNS	Number=Plur	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	appreciable	appreciable	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	supported	support	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	globin	globin	ADP	IN	_	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4751
# text = Truncation of the beta globin promoter led to a 2-3 fold increase in promoter activity.
1	Truncation	Truncation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4752
# text = In contrast, deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4753
# text = Coupling of the upstream beta globin sequence from approximately -500 to -250 bp to the truncated delta promoter fragment led to complete extinction of transcription activity, consistent with a negative regulatory effect of the beta globin gene upstream element(s).
1	Coupling	Coupling	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	approximately	approximately	ADV	RB	_	_	_	_	_
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	500	500	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	250	250	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
22	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
25	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
39	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
42	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	s	s	X	AFX	_	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4754
# text = Fusion of the upstream portion of the delta promoter to the truncated beta globin promoter yielded a modest increase in promoter strength relative to the truncated beta gene promoter, indicating the presence of a positive transcriptional element(s) in the upstream delta globin regulatory region.
1	Fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	modest	modest	ADJ	JJ	Degree=Pos	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	strength	strength	NOUN	NN	Number=Sing	_	_	_	_
23	relative	relative	ADV	RB	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
38	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	s	s	X	AFX	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
45	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
46	globin	globin	ADP	IN	_	_	_	_	_
47	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
48	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4755
# text = Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	SCONJ	IN	_	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	BP1	BP1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	BP2	BP2	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
18	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	_
32	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
33	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4756
# text = DNase I footprinting of the upstream delta-globin region revealed protected sequences corresponding to consensus binding sites for GATA-1 and BP2.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
7	delta	delta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
14	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	consensus	consensus	VERB	VB	VerbForm=Inf	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	BP2	BP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4757
# text = These results confirm that sequences in the upstream promoter region of the adult beta globin gene contribute to its factor-mediated suppression early in development and then may modulate its expression at a later stage.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	globin	globin	ADP	IN	_	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
24	early	early	ADV	RB	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	then	then	ADV	RB	PronType=Dem	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
36	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4758
# text = Document 003001350 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001350	003001350	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4759
# text = Characterization of the human immunodeficiency virus type 1 enhancer-binding proteins from the human T-cell line Jurkat.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4760
# text = The transcription of the human immunodeficiency virus type 1 (HIV-1) is under the control of cellular proteins that bind to the viral long terminal repeat (LTR).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4761
# text = Among the protein-binding regions of the HIV-1 LTR is the transcription-enhancer region.
1	Among	among	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4762
# text = We show that at least one inducible, C1, and one constitutive, C2, protein can bind to the HIV enhancer in Jurkat cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	at	at	ADV	RB	_	_	_	_	_
5	least	least	ADV	RBS	Degree=Sup	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	C1	C1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	C2	c2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4763
# text = The two proteins differ in their surface charge, since they are separable by anion-exchange chromatography.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
8	charge	charge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	since	since	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	separable	separable	ADJ	JJ	Degree=Pos	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	anion	anion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
18	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4764
# text = Bivalent cations such as Mg2+ and Zn2+ differentially affect their binding to oligonucleotides which contain the HIV-enhancer domain.
1	Bivalent	Bivalent	ADJ	JJ	Degree=Pos	_	_	_	_
2	cations	cation	NOUN	NNS	Number=Plur	_	_	_	_
3	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	Mg2	Mg2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Zn2	Zn2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	differentially	differentially	ADV	RB	_	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4765
# text = Both C1 and C2 proteins also bind to a similar sequence found in the interleukin-2-receptor alpha-subunit enhancer.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	C1	c1	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	C2	C2	NUM	CD	NumType=Card	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4766
# text = The inducible C1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a 47 kDa protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	C1	C1	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	partially	partially	ADV	RB	_	_	_	_	_
7	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	chromatographic	chromatographic	ADJ	JJ	Degree=Pos	_	_	_	_
11	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	u.v.	u.v.	NOUN	NN	Number=Sing	_	_	_	_
16	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	47	47	NUM	CD	NumType=Card	_	_	_	_
21	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4767
# text = Document 003001351 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001351	003001351	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4768
# text = Mechanisms of transactivation by nuclear factor of activated T cells-1.
1	Mechanisms	Mechanism	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4769
# text = Nuclear factor of activated T cells-family proteins (NFAT1/NFATp, NFATc, NFAT3, and NFAT4/NFATx/NFATc3) play a key role in the transcription of cytokine genes and other genes during the immune response.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	NFAT3	NFAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NFAT4/NFATx	NFAT4/NFATx	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	NFATc3	NFATc3	X	LS	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4770
# text = We have defined the mechanisms of transactivation by NFAT1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4771
# text = NFAT1 possesses two transactivation domains whose sequences are not conserved in the other NFAT-family proteins, and a conserved DNA-binding domain that mediates the recruitment of cooperating nuclear transcription factors even when it is expressed in the absence of other regions of the protein.
1	NFAT1	NFAT1	NUM	CD	NumType=Card	_	_	_	_
2	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
6	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	cooperating	cooperate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	even	even	ADV	RB	_	_	_	_	_
36	when	when	ADV	WRB	PronType=Int	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
45	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4772
# text = The activity of the NH2-terminal transactivation domain is modulated by an adjacent regulatory region that contains several conserved sequence motifs represented only in the NFAT family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
8	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
23	represented	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NFAT	NFAT	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4773
# text = Our results emphasize the multiple levels at which NFAT-dependent transactivation is regulated, and predict significant differences in the architecture of cooperative transcription complexes containing different NFAT-family proteins.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	NFAT	NFAT	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	predict	predict	VERB	VB	VerbForm=Inf	_	_	_	_
18	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
19	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	architecture	architecture	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
28	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
29	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	family	family	NOUN	NN	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4774
# text = Document 003001352 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001352	003001352	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4775
# text = Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	+/	+/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	IV	iv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4776
# text = The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CaMK	CaMK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	IV	iv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	selectively	selectively	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	after	after	SCONJ	IN	_	_	_	_	_
24	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	T	T	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	some	some	DET	DT	_	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	events	event	NOUN	NNS	Number=Plur	_	_	_	_
50	that	that	PRON	WDT	PronType=Rel	_	_	_	_
51	follow	follow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
52	TCR	Tcr	ADJ	JJ	Degree=Pos	_	_	_	_
53	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4777
# text = Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
8	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
32	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4778
# text = CaMKIV/
1	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	_

# sent_id = 4779
# text = Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin.
1	Gr	Gr	NOUN	NN	Number=Sing	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4780
# text = AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells.
1	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
7	component	component	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	interleukin	interleukin	ADV	RB	_	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4781
# text = We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
7	reconstitutes	reconstitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
13	component	component	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	direct	direct	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	no	no	DET	DT	_	_	_	_	SpaceAfter=No
24	n-T	n-t	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4782
# text = These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4783
# text = Document 003001353 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001353	003001353	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4784
# text = Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4785
# text = Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-1alpha (IL-1alpha).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	constitutively	constitutively	ADV	RB	_	_	_	_	_
19	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
20	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4786
# text = To analyze the mechanisms that lead to the expression of IL-1alpha in HTLV-I-infected cell lines, we studied regulatory regions of the human IL-1alpha promoter involved in activation of the IL-1alpha gene.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4787
# text = IL-1alpha promoter constructs drive transcription of the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells, which constitutively produce IL-1alpha.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
6	drive	drive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	MT	mt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	constitutively	constitutively	ADV	RB	_	_	_	_	_
30	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	IL	il	ADV	RB	_	_	_	_	SpaceAfter=No
32	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4788
# text = In a cotransfection assay, the Tax protein of both HTLV-I and HTLV-II specifically activated transcription from the IL-1alpha promoter in an uninfected Jurkat cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	II	II	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	specifically	specifically	ADV	RB	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4789
# text = A mutant Tax protein deficient in transactivation of genes by the nuclear factor (NF)-kappaB pathway was unable to induce transcriptional activity of IL-1alpha promoter-CAT constructs, but was rescued by exogenous provision of p65/p50 NF-kappaB.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
3	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-1alpha	-1alpha	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
32	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
39	provision	provision	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	p65/p50	p65/p50	NUM	CD	NumType=Card	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4790
# text = We found that two IL-1alpha kappaB-like sites (positions -1,065 to -1,056 and +646 to +655) specifically formed a complex with NF-kappaB-containing nuclear extract from MT-2 cells and that NF-kappaB bound with higher affinity to the 3' NF-kappaB binding site than to the 5' NF-kappaB site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	like	like	SCONJ	IN	_	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1,065	1,065	NUM	CD	NumType=Card	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	-1,056	-1,056	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	+646	+646	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	+655	+655	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
45	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
48	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	'	'	PUNCT	``	_	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
56	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
57	site	site	NOUN	NN	Number=Sing	_	_	_	_
58	than	than	ADP	IN	_	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	'	's	NOUN	NN	Number=Sing	_	_	_	_
63	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
66	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4791
# text = Moreover, deletion of either 5' or 3' NF-kappaB sites reduced IL-1alpha promoter activity in MT-2 cells and transactivation of the IL-1alpha promoter by exogenous NF-kappaB and Tax in Jurkat cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	either	either	CCONJ	CC	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4792
# text = These data suggest a general role for Tax induction of IL-1alpha gene transcription by the NF-kappaB pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4793
# text = Expression of IL-1alpha by HTLV-I productively infected cells may be important in the hypercalcemia, osteolytic bone lesions, neutrophilia, elevation of C-reactive protein, and fever frequently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	productively	productively	ADV	RB	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	hypercalcemia	hypercalcemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	osteolytic	osteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
22	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	neutrophilia	neutrophilia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	fever	fever	ADV	RB	_	_	_	_	_
34	frequently	frequently	ADV	RB	_	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
45	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4794
# text = Document 003001354 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001354	003001354	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4795
# text = USF-related transcription factor, HIV-TF1, stimulates transcription of human immunodeficiency virus-1.
1	USF	USF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	TF1	tF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4796
# text = The transcription factor HIV-TF1, which binds to a region about 60 bp upstream from the enhancer of the human immunodeficiency virus-1 (HIV-1), was purified from human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	TF1	tF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	about	about	ADP	IN	_	_	_	_	_
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4797
# text = HIV-TF1 had a molecular weight of 39,000.
1	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	TF1	tF1	PROPN	NNP	Number=Sing	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	39,000	39,000	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4798
# text = Binding of HIV-TF1 to the HIV long terminal repeat (LTR) activated transcription from the HIV promoter in vitro.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4799
# text = The HIV-TF1-binding site in HIV LTR was similar to the site recognized by upstream stimulatory factor (USF) in the adenovirus major late promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	TF1	tF1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
10	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
27	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
28	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4800
# text = DNA-binding properties of HIV-TF1 suggested that HIV-TF1 might be identical or related to USF.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
9	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
14	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4801
# text = Interestingly, treatment of purified HIV-TF1 by phosphatase greatly reduced its DNA-binding activity, suggesting that phosphorylation of HIV-TF1 was essential for DNA binding.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	TF1	tF1	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
11	greatly	greatly	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	DNA	DNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	SCONJ	IN	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4802
# text = The disruption of HIV-TF1-binding site induced a 60% decrease in the level of transcription from the HIV promoter in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	TF1	tF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	%	%	SYM	NN	Number=Sing	_	_	_	_
14	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4803
# text = These results suggest that HIV-TF1 is involved in transcriptional regulation of HIV-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	TF1	tF1	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4804
# text = Document 003001355 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001355	003001355	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4805
# text = An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
15	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4806
# text = The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	SCONJ	IN	_	_	_	_	_
31	alternatively	alternatively	ADV	RB	_	_	_	_	_
32	mediating	mediating	VERB	VBG	VerbForm=Ger	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	protecting	protect	VERB	VBG	VerbForm=Ger	_	_	_	_
35	against	against	ADP	IN	_	_	_	_	_
36	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4807
# text = However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	+)	+)	SYM	NFP	_	_	_	_	_
14	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4808
# text = We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	virtually	virtually	ADV	RB	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	+)	+)	PUNCT	-RRB-	_	_	_	_	_
12	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
13	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
27	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
30	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	eg	eg	X	FW	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
42	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
54	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
57	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4809
# text = In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	+)	+)	SYM	NFP	_	_	_	_	_
18	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	clonogenic	clonogenic	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4810
# text = These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	offer	offer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	insight	insight	ADV	RB	_	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
29	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
30	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	adjunct	adjunct	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
41	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	_
42	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
43	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
44	approached	approach	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	caution	caution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4811
# text = Document 003001356 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001356	003001356	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4812
# text = Interleukin-2 promoter activity in Epstein-Barr virus-transformed
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-transformed	-transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 4813
# text = B lymphocytes is controlled by nuclear factor-chi B.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4814
# text = The regulation of interleukin (IL)-2 gene expression has been investigated mainly in T lymphocytes, the predominant producers of IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	mainly	mainly	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
22	producers	producer	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4815
# text = However, B cells can also synthesize IL-2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	synthesize	synthesize	VERB	VB	VerbForm=Inf	_	_	_	_
8	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4816
# text = In the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
31	of	of	SCONJ	IN	_	_	_	_	_
32	secreting	secret	VERB	VBG	VerbForm=Ger	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	_
40	after	after	ADP	IN	_	_	_	_	_
41	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
44	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
47	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	+	+	SYM	SYM	_	_	_	_	_
54	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
55	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4817
# text = Transient transfections using reporter constructs with multiples of transcription factor binding sites from the IL-2 promoter [distal nuclear factor (NF)-AT, proximal NF-AT, AP-1/Octamer (UPS) or NF-chi B (TCEd) sites] were performed.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	multiples	multiple	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	AT	at	ADV	RB	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	UPS	ups	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
46	B	b	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	]	]	PUNCT	-RRB-	_	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4818
# text = In EBV-transformed B clones, the chi B site exerted the strongest inducible activity; the NF-AT binding sites showed either no or only weak activity compared to Jurkat T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	exerted	exert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	strongest	strongest	ADJ	JJS	Degree=Sup	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	AT	at	SCONJ	IN	_	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	no	no	DET	DT	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4819
# text = An IL-2 promoter bearing a defective NF-chi B site was completely inactive in EBV-transformed B cells, while it still had activity in Jurkat T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	completely	completely	ADV	RB	_	_	_	_	_
16	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	still	still	ADV	RB	_	_	_	_	_
27	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4820
# text = In seven EBV-B cell clones or lines differing in their capacity to secrete IL-2, the activity of the IL-2 promoter correlated well with the status of IL-2 secretion.
1	In	in	ADP	IN	_	_	_	_	_
2	seven	seven	NUM	CD	NumType=Card	_	_	_	_
3	EBV	Ebv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	differing	differ	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	secrete	secrete	VERB	VB	VerbForm=Inf	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	status	status	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4821
# text = Similarly, a human immunodeficiency virus promoter, whose activity is controlled through chi B factors, was found to be active in the IL-2 producing EBV-B cells, but inactive in the non-IL-2-producing cells.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
29	EBV	Ebv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	non-IL	non-il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4822
# text = Electrophoretic mobility shift assays using protein extracts from EBV-B cells and the IL-2 NF-chi B probe revealed the constitutive generation of chi B complexes in IL-2-secreting cells consisting mainly of heterodimeric p50/p65 complexes.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	probe	probe	ADV	RB	_	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	chi	chi	ADJ	JJ	Degree=Pos	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	secreting	secreting	VERB	VBG	VerbForm=Ger	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	consisting	consist	VERB	VBG	VerbForm=Ger	_	_	_	_
39	mainly	mainly	ADV	RB	_	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
42	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
45	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4823
# text = A weaker chi B complex formation and faster-migrating complexes were detected in non-IL-2-secreting cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	weaker	weaker	NOUN	NN	Number=Sing	_	_	_	_
3	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	non-IL	non-il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	secreting	secreting	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4824
# text = These results demonstrate that the IL-2 NF-chi B site is indispensable for the activity of the IL-2 promoter in EBV-transformed B cells, whereas other transcription factors appear to be less important for IL-2 expression in these cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	indispensable	indispensable	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	whereas	whereas	SCONJ	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
39	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
40	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4825
# text = Document 003001357 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001357	003001357	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4826
# text = Prostaglandin E2
1	Prostaglandin	Prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
2	E2	E2	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4827
# text = Up-regulates HIV-1 long terminal repeat-driven gene activity in T cells via NF-kappaB-dependent and -independent signaling pathways.
1	Up-	Up-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4828
# text = Replication of human immunodeficiency virus type-1 (HIV-1) is highly dependent on the state of activation of the infected cells and is modulated by interactions between viral and host cellular factors.
1	Replication	Replication	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	state	state	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	host	host	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4829
# text = Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, is observed at elevated levels during HIV-1 infection as well as during the course of other pathogenic infections.
1	Prostaglandin	Prostaglandin	PROPN	NNP	Number=Sing	_	_	_	_
2	E2	E2	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	course	course	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
31	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4830
# text = In 1G5, a Jurkat-derived T cell line stably transfected with a luciferase gene driven by HIV-1 long terminal repeat (LTR), we found that PGE2 markedly enhanced HIV-1 LTR-mediated reporter gene activity.
1	In	in	ADP	IN	_	_	_	_	_
2	1G5	1G5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	stably	stably	ADV	RB	_	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	_
33	markedly	markedly	ADV	RB	_	_	_	_	_
34	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4831
# text = Experiments have been conducted to identify second messengers involved in this PGE2-dependent up-regulating effect on the regulatory element of HIV-1.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
7	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4832
# text = In this study, we present evidence indicating that signal transduction pathways induced by PGE2 necessitate the participation of cyclic AMP, protein kinase A, and Ca2+.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	PGE2	Pge2	NUM	CD	NumType=Card	_	_	_	_
16	necessitate	necessitate	NOUN	NN	Number=Sing	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
21	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4833
# text = Experiments conducted with different HIV-1 LTR-based vectors suggested that PGE2-mediated activation effect on HIV-1 transcription was transduced via both NF-kappaB-dependent and -independent signaling pathways.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
12	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	PGE2	Pge2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	via	via	ADP	IN	_	_	_	_	_
27	both	both	DET	DT	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
36	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
37	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4834
# text = The involvement of NF-kappaB in the PGE2-dependent activating effect on HIV-1 transcription was further confirmed using a kappaB-regulated luciferase encoding vector and by electrophoretic mobility shift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	activating	activate	NOUN	NN	Number=Sing	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	further	further	ADV	RB	_	_	_	_	_
21	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
28	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
29	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
33	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
34	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
35	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4835
# text = Results from Northern blot and flow cytometric analyses, as well as the use of a selective antagonist indicated that PGE2 modulation of HIV-1 LTR-driven reporter gene activity in studied T lymphoid cells is transduced via the EP4 receptor subtype.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
4	blot	blot	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
7	cytometric	cytometric	ADJ	JJ	Degree=Pos	_	_	_	_
8	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	use	use	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
18	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
19	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
22	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	via	via	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	EP4	EP4	PROPN	NNP	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	subtype	subtype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4836
# text = These results suggest that secretion of PGE2 by macrophages in response to infection or inflammatory activators could induce signaling events resulting in activation of proviral DNA present into T cells latently infected with HIV-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
20	events	event	NOUN	NNS	Number=Plur	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	latently	latently	ADV	RB	_	_	_	_	_
32	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4837
# text = Document 003001358 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001358	003001358	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4838
# text = Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
17	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4839
# text = HIV-1 proviral DNA contains two binding sites for the transcription factor NF-kappa B. HIV-1-infected individuals have, on average, abnormally high levels of tumour necrosis factor alpha (TNF alpha) and abnormally low plasma cysteine levels.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-infected	-infected	ADJ	JJ	Degree=Pos	_	_	_	_
23	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
24	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	average	average	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	abnormally	abnormally	ADV	RB	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
34	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	abnormally	abnormally	ADV	RB	_	_	_	_	_
43	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
44	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
45	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
46	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4840
# text = We therefore investigated the effects of cysteine and related thiols on HIV-1 replication and NF-kappa B expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4841
# text = The experiments in this report show that cysteine or N-acetylcysteine (NAC) raise the intracellular glutathione (GSH) level and inhibit HIV-1 replication in persistently infected Molt-4 and U937 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GSH	GSH	INTJ	UH	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	persistently	persistently	ADV	RB	_	_	_	_	_
31	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	Molt	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	U937	U937	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4842
# text = However, inhibition of HIV-1 replication appears not to be directly correlated with GSH levels.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	directly	directly	ADV	RB	_	_	_	_	_
14	correlated	correlated	ADJ	JJ	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	GSH	Gsh	DET	DT	_	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4843
# text = Cysteine and NAC also inhibit NF-kappa B activity as determined by electrophoretic mobility shift assays and chloramphenicol acetyl-transferase (CAT) gene expression under control of NF-kappa B binding sites in uninfected cells.
1	Cysteine	Cysteine	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
15	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
20	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	under	under	ADP	IN	_	_	_	_	_
29	control	control	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4844
# text = This suggests that the cysteine deficiency in HIV-1-infected individuals may cause an over-expression of NF-kappa B-dependent genes and enhance HIV-1 replication.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
6	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-infected	-infect	ADJ	JJ	Degree=Pos	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	over-expression	over-expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4845
# text = NAC may be considered for the treatment of HIV-1-infected individuals.
1	NAC	Nac	PROPN	NNP	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4846
# text = Document 003001359 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001359	003001359	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4847
# text = Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4848
# text = This study examined the effects of leukemia inhibitory factor (LIF) on human immunodeficiency virus (HIV) replication in mononuclear phagocytes (MNP).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LIF	LIF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	MNP	MNP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4849
# text = LIF induced a dose-dependent increase in p24 antigen production in the chronically infected promonocytic cell line U1. The magnitude and time kinetics of the LIF effects were similar to interleukin 1 (IL-1), IL-6, and tumor necrosis factor (TNF), other cytokines known to induce HIV replication in this cell line.
1	LIF	LIF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	p24	p24	NUM	CD	NumType=Card	_	_	_	_
10	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	chronically	chronically	ADV	RB	_	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	U1	u1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_
21	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LIF	Lif	PROPN	NNP	Number=Sing	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
47	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
54	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
55	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	induce	induce	PROPN	NNP	Number=Sing	_	_	_	_
58	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
59	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
60	in	in	ADP	IN	_	_	_	_	_
61	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
62	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
63	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4850
# text = To characterize mechanisms responsible for these LIF effects, levels of HIV mRNA, activation of the DNA binding protein nuclear factor (NF)-kB, signal transduction pathways, and potential interactions with other cytokines were analyzed.
1	To	to	ADP	IN	_	_	_	_	_
2	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	LIF	Lif	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	protein	protein	ADV	RB	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	kB	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
35	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4851
# text = LIF increased steady-state levels of HIV mRNA at 2.0, 4.3, and 9.2 kB.
1	LIF	Lif	AUX	VB	VerbForm=Inf	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	state	state	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	2.0	2.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	4.3	4.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	9.2	9.2	NUM	CD	NumType=Card	_	_	_	_
17	kB	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4852
# text = This was detectable by 24 h and persisted until 72 h.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	24	24	NUM	CD	NumType=Card	_	_	_	_
6	h	h	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	persisted	persist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	until	until	ADP	IN	_	_	_	_	_
10	72	72	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4853
# text = The DNA binding protein NF-kB is a central mediator in cytokine activation of HIV transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4854
# text = NF-kB
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4855
# text = levels were higher in unstimulated U1 cells as compared to the parent cell line U937.
1	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
6	U1	U1	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	parent	parent	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4856
# text = In both cell lines LIF increased NF-kB activity.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	LIF	Lif	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4857
# text = Induction of NF-kB and HIV replication by cytokines are at least in part dependent on reactive oxygen intermediates.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	part	part	ADJ	JJ	Degree=Pos	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
20	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4858
# text = The oxygen radical scavenger N-acetyl-L-cysteine, but not an inhibitor of nitric oxide synthase, inhibited LIF-induced HIV replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
3	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
4	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
5	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-L	-l	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
17	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
18	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	LIF	LIF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
25	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4859
# text = LIF induces the production of other cytokines in monocytes but its effects on HIV replication were not inhibited by antibodies to IL-1, TNF, or IL-6.
1	LIF	LIF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	effects	effect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4860
# text = These results identify LIF as a stimulus of HIV replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	LIF	LIF	ADP	RP	_	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4861
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4862
# text = Document 003001360 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001360	003001360	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4863
# text = Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
5	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4864
# text = The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in regulating cell-cycle progression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4865
# text = p27Kip1
1	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4866
# text = directly inhibits the catalytic activity of cyclin/cdks (cyclin-dependent kinase) complexes and/or interferes physically with cyclin/cdks activation by CAK.
1	directly	directly	ADV	RB	_	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	cdks	cdk	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	or	or	CCONJ	CC	_	_	_	_	_
20	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	physically	physically	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	cdks	cdk	NOUN	NNS	Number=Plur	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	CAK	CAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4867
# text = Interestingly, the expression level of p27Kip1 mRNA was maximal in resting Go T-cells and rapidly declined following anti-CD3 activation.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p27Kip1	p27Kip1	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Go	go	PROPN	NNP	Number=Sing	_	_	_	_
14	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
20	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4868
# text = We report here the cloning of p27Kip1 gene from murine genomic DNA and the functional analysis of the promoter of the p27Kip1 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p27Kip1	p27Kip1	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	murine	murine	PRON	PRP	_	_	_	_	_
11	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4869
# text = The gene consists of at least three exons and spans more than 5.6 kb of DNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	spans	span	NOUN	NNS	Number=Plur	_	_	_	_
11	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	5.6	5.6	NUM	CD	NumType=Card	_	_	_	_
14	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4870
# text = Primer extension and nuclease S1 protection analysis revealed two major transcription initiation sites.
1	Primer	Primer	NOUN	NN	Number=Sing	_	_	_	_
2	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	_
5	S1	s1	NOUN	NN	Number=Sing	_	_	_	_
6	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4871
# text = The promoter region lacked a TATA box but contained potential binding sites for the transcriptional factors including two Sp1, CRE, Myb and NFkB located at positions -153, -178, -286, -875, and -1011, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NFkB	NFkB	PROPN	NNP	Number=Sing	_	_	_	_
26	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
29	-153	-153	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	178	178	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	-286	-286	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	875	875	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	1011	1011	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4872
# text = To analyze the regulatory mechanisms controlling p27Kip1 gene expression, we characterized the 5'-flanking region from nt -1609 to +178. The -326 to -615 region contained positive regulatory elements.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
7	p27Kip1	p27kip1	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	nt	not	PART	RB	_	_	_	_	_
21	-1609	-1609	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
24	178	178	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_
26	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	-326	-326	NUM	CD	NumType=Card	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	615	615	NUM	CD	NumType=Card	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4873
# text = Document 003001361 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001361	003001361	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4874
# text = Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
23	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RE	re	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4875
# text = IL-2 gene transcription in T cells requires both TCR and costimulatory signals.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	TCR	Tcr	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4876
# text = IL-2 promoter activation in Jurkat T cells stimulated with superantigen presented by Raji B cells requires CD28 activation.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	superantigen	superantigen	NOUN	NNS	Number=Plur	_	_	_	_
13	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4877
# text = The addition of rCTLA4
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	rCTLA4	rCTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 4878
# text = Ig, which blocks CD28 binding to its ligand, to the cultures decreased IL-2 promoter activation by >80%. Interestingly, CTLA4Ig did not significantly inhibit the activation of either NF of activated T cells (NFAT) or AP-1 reporters.
1	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	>	>	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	80%	80%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_
24	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	CTLA4	CTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	significantly	significantly	ADV	RB	_	_	_	_	_
31	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	either	either	CCONJ	CC	_	_	_	_	_
36	NF	Nf	ADP	IN	_	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	reporters	reporter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4879
# text = Therefore, activation of NFAT and AP-1 is insufficient for IL-2 promoter activation.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4880
# text = In contrast, an RE/AP reporter was blocked by CTLA4Ig by >90%.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	RE	re	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	CTLA4	CTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	>90%	>90%	X	XX	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4881
# text = Thus, the requirement for CD28 in IL-2 promoter activation appears to be due to RE/AP and not the NFAT or AP-1 sites.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	RE	re	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4882
# text = In addition, these data suggest that transcriptional activation of RE/AP is not mediated by NFAT, because activation of a NFAT reporter is not affected by the addition of CTLA4Ig.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	RE	re	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	NFAT	NFAT	ADJ	JJ	Degree=Pos	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	CTLA4	CTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4883
# text = Document 003001362 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001362	003001362	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4884
# text = Anoxia/reoxygenation-induced tolerance with respect to polymorphonuclear leukocyte adhesion to cultured endothelial cells.
1	Anoxia/	Anoxia/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	polymorphonuclear	polymorphonuclear	VERB	VB	VerbForm=Inf	_	_	_	_
10	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	cultured	cultured	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4885
# text = A nuclear factor-kappaB-mediated phenomenon.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4886
# text = Exposing human umbilical vein endothelial cells (HUVECs) to anoxia/reoxygenation (A/R) results in an increase in polymorphonuclear leukocyte (PMN) adhesion to HUVECs.
1	Exposing	Expose	VERB	VBG	VerbForm=Ger	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
4	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	anoxia	anoxia	ADP	IN	_	_	_	_	SpaceAfter=No
12	/reoxygenation	/reoxygenation	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	A/	Aith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	R	R	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMN	PMN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4887
# text = This A/R-induced hyperadhesion is completely prevented by a previous (24 hours earlier) exposure of HUVECs to A/R.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	A/R-induced	A/R-induced	ADJ	JJ	Degree=Pos	_	_	_	_
3	hyperadhesion	hyperadhesion	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	completely	completely	ADV	RB	_	_	_	_	_
6	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	24	24	NUM	CD	NumType=Card	_	_	_	_
12	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
13	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	A/R.	A/R.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4888
# text = This phenomenon has been termed "A/R tolerance."
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
7	A/R	A/r	ADJ	JJ	Degree=Pos	_	_	_	_
8	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpaceAfter=No
10	"	"	PUNCT	''	_	_	_	_	_

# sent_id = 4889
# text = Exposing HUVECs to A/R induces an increase in nuclear factor kappaB (NF-kappaB) in HUVEC nuclei within 4 hours.
1	Exposing	Expose	VERB	VBG	VerbForm=Ger	_	_	_	_
2	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	A/R	A/R	PROPN	NNP	Number=Sing	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HUVEC	Huvec	PROPN	NNP	Number=Sing	_	_	_	_
19	nuclei	nuclei	PROPN	NNP	Number=Sing	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4890
# text = Interfering with either NF-kappaB activation (proteasome inhibitor) or translocation (double-stranded oligonucleotides containing NF-kappaB binding sequence) prevents the development of A/R tolerance (ie, the increase in A/R-induced PMN adhesion to HUVECs is the same after the first and second A/R challenges).
1	Interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	either	either	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stranded	stranded	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	oligonucleotides	oligonucleotides	NOUN	NNS	Number=Plur	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
31	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	A/R-	A/R-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	PMN	Pmn	ADP	IN	_	_	_	_	_
41	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
47	after	after	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
52	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
53	challenges	challenge	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4891
# text = NO production by HUVECs is increased after the second A/R challenge, but not after the first A/R challenge.
1	NO	no	DET	DT	_	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
11	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
19	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4892
# text = Inhibition of NO synthase (NOS) during the second A/R challenge prevents the development of A/R tolerance with respect to PMN adhesion.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NO	no	DET	DT	_	_	_	_	_
4	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NOS	NOS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
12	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	_
13	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	A/R	A/r	ADJ	JJ	Degree=Pos	_	_	_	_
18	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	PMN	Pmn	VERB	VB	VerbForm=Inf	_	_	_	_
23	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4893
# text = However, while HUVECs contained endothelial NOS protein, no inducible NOS was detected in either tolerant or nontolerant cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	HUVECs	Huvecs	NOUN	NNS	Number=Plur	_	_	_	_
5	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	NOS	no	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	NOS	Nos	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	nontolerant	nontolerant	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4894
# text = Further studies indicated that inhibition of GTP-cyclohydrolase I (an enzyme involved in de novo synthesis of an important cofactor for NOS activity, tetrahydrobiopterin) prevented the generation of NO in A/R-tolerant cells.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cyclohydrolase	cyclohydrolase	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
14	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	de	de	PROPN	NNP	Number=Sing	_	_	_	_
17	novo	novo	ADV	RB	_	_	_	_	_
18	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	NOS	NOS	PROPN	NNP	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	tetrahydrobiopterin	tetrahydrobiopterin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NO	no	DET	DT	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	A/R-	A/R-	X	AFX	_	_	_	_	SpaceAfter=No
36	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4895
# text = Extracellular generation of NO (NO donor) did not effect the hyperadhesion response induced by the initial A/R challenge.
1	Extracellular	Extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NO	no	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NO	no	DET	DT	_	_	_	_	_
7	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	effect	effect	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	hyperadhesion	hyperadhesion	NOUN	NN	Number=Sing	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
19	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
20	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4896
# text = A/R also induced an oxidant stress in naive HUVECs, but not in A/R-tolerant HUVECs.
1	A/R	A/R	ADV	RB	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
6	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
9	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	A/R-	A/R-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
16	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4897
# text = Inhibition of NOS during the second A/R insult results in the generation of an oxidant stress similar to that observed after the first A/R challenge.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NOS	no	PROPN	NNP	Number=Sing	_	_	_	_
4	during	during	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
8	insult	insult	NOUN	NN	Number=Sing	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
16	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
24	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
25	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4898
# text = Taken together, the findings of the present study are consistent with a role for NF-kappaB in the development of A/R tolerance (with respect to PMN adhesion), perhaps by transcriptional regulation of GTP-cyclohydrolase.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	study	study	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	A/R	A/r	PROPN	NNP	Number=Sing	_	_	_	_
24	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	with	with	ADP	IN	_	_	_	_	_
27	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	PMN	Pmn	X	GW	_	_	_	_	_
30	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	perhaps	perhaps	ADV	RB	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	cyclohydrolase	cyclohydrolase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4899
# text = The increased NO production during the second A/R insult reduces PMN adhesion most likely by reducing the intracellular oxidant stress induced by A/R.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NO	no	DET	DT	_	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
9	insult	insult	NOUN	NN	Number=Sing	_	_	_	_
10	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	PMN	PMN	X	GW	_	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	most	most	ADV	RBS	_	_	_	_	_
14	likely	likely	ADV	RB	_	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
20	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	A/	A/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
24	R.	R.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4900
# text = Document 003001363 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001363	003001363	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4901
# text = Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor.kappa	factor.kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C	C	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4902
# text = Autocrine role of tumor necrosis factor alpha.
1	Autocrine	Autocrine	PROPN	NNP	Number=Sing	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4903
# text = The regulation of interleukin-2 receptor alpha chain (IL-2R alpha) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	C	C	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4904
# text = Treatment of human resting T cells with phorbol esters strongly induced the expression of IL-2R alpha and the activation of NF.kappa B.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
10	strongly	strongly	ADV	RB	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4905
# text = This activation was due to the translocation of p65 and c-Rel NF.kappa B proteins from cytoplasmic stores to the nucleus, where they bound the kappa B sequence of the IL-2R alpha promoter either as p50.p65 or as p50.c-Rel heterodimers.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	due	due	ADP	IN	_	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	stores	store	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	where	where	ADV	WRB	PronType=Rel	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	either	either	CCONJ	CC	_	_	_	_	_
39	as	as	ADP	IN	_	_	_	_	_
40	p50.p65	p50.p65	NUM	CD	NumType=Card	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	p50.c	p50.c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
46	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4906
# text = Interestingly, all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor alpha (TNF alpha), as they were strongly inhibited by a neutralizing anti-TNF alpha monoclonal antibody.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	events	event	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	largely	largely	ADV	RB	_	_	_	_	_
9	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	endogenously	endogenously	ADV	RB	_	_	_	_	_
14	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
16	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	strongly	strongly	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	neutralizing	neutralizing	ADJ	JJ	Degree=Pos	_	_	_	_
32	anti-TNF	anti-tnf	NOUN	NN	Number=Sing	_	_	_	_
33	alpha	alpha	ADP	IN	_	_	_	_	_
34	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
35	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4907
# text = Furthermore, cyclosporin A, which blocked TNF alpha production induced by PKC, strongly inhibited IL-2R alpha and NF.kappa B activation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclosporin	cyclosporin	ADP	IN	_	_	_	_	_
4	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	strongly	strongly	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	B	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4908
# text = The addition of either TNF alpha or IL-2 partially recovered cyclosporin A-induced IL-2R alpha inhibition, but only TNF alpha completely recovered NF.kappa B activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	partially	partially	ADV	RB	_	_	_	_	_
12	recovered	recover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	completely	completely	ADV	RB	_	_	_	_	_
28	recovered	recover	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4909
# text = Those results indicate that, in resting T cells, PKC activation has only a triggering role, whereas the endogenously secreted TNF alpha plays an essential role in the quantitative control of the expression of IL-2R alpha chain or NF.kappa B activation.
1	Those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	endogenously	endogenously	ADV	RB	_	_	_	_	_
22	secreted	secret	ADJ	JJ	Degree=Pos	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
41	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	b	PROPN	NNP	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4910
# text = Document 003001364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001364	003001364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4911
# text = Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
1	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
11	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	spi	spi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4912
# text = PU.1 (spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid and B cells, activates many B cell and myeloid genes, and is critical for development of both of these lineages.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	spi	spi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	member	member	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	predominantly	predominantly	ADV	RB	_	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	development	development	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	both	both	DET	DT	_	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4913
# text = Our previous studies (Chen, H.M., Ray-Gallet, D., Zhang, P., Hetherington, C.J., Gonzalez, D.A., Zhang, D.-E., Moreau-Gachelin, F., and Tenen, D.G.(1995) Oncogene 11, 1549-1560) demonstrate that the PU.1 promoter directs cell type-specific reporter gene expression in myeloid cell lines, and that PU.1 activates its own promoter in an autoregulatory loop.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Chen	Chen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	H.M.	H.M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Ray	Ray	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Gallet	Gallet	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	D.	D.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Zhang	Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	P.	P.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Hetherington	Hetherington	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	C.J.	C.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Gonzalez	Gonzalez	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	D.A.	D.A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Zhang	Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	D.-E.	D.-E.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	Moreau-Gachelin	Moreau-Gachelin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	F.	F.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Tenen	Tenen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	D.G.	D.G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	1995	1995	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	Oncogene	Oncogene	NOUN	NN	Number=Sing	_	_	_	_
43	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	1549	1549	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	1560	1560	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	that	that	SCONJ	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
53	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
54	directs	directs	NOUN	NNS	Number=Plur	_	_	_	_
55	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
59	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
60	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
64	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
65	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	and	and	CCONJ	CC	_	_	_	_	_
68	that	that	SCONJ	IN	_	_	_	_	_
69	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
70	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
71	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
72	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
73	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
74	in	in	ADP	IN	_	_	_	_	_
75	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
76	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
77	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4914
# text = Here we show that the murine PU.1 promoter is also specifically and highly functional in B cell lines as well. Oct-1 and Oct-2 can bind specifically to a site at base pair -55 in vitro, and this site is specifically protected in B cells in vivo.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	specifically	specifically	ADV	RB	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_
22	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-1	-1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
30	specifically	specifically	ADV	RB	_	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	base	base	NOUN	NN	Number=Sing	_	_	_	_
36	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	55	55	NUM	CD	NumType=Card	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	site	site	NOUN	NN	Number=Sing	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	specifically	specifically	ADV	RB	_	_	_	_	_
47	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4915
# text = We also demonstrate that two other sites contribute to promoter activity in B cells; an Sp1 binding site adjacent to the octamer site, and the PU.1 autoregulatory site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	adjacent	adjacent	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
29	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4916
# text = Finally, we show that the B cell coactivator OBF-1/Bob1/OCA-B is only expressed in B cells and not in myeloid cells, and that OBF-1/Bob1/OCA-B can transactivate the PU.1 promoter in HeLa and myeloid cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
10	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-1/Bob1/	-1/Bob1ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	OCA	Oca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-1/	-1ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	Bob1/OCA	Bob1/OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4917
# text = This B cell restricted coactivator may be responsible for the B cell specific expression of PU.1 mediated by the octamer site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4918
# text = Document 003001365 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001365	003001365	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4919
# text = Central nervous system-derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR-independent transactivation by Tat.
1	Central	Central	ADJ	JJ	Degree=Pos	_	_	_	_
2	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	facilitates	facilitate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	TAR	Tar	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4920
# text = The
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_

# sent_id = 4921
# text = Tat protein of human immunodeficiency virus type 1 (HIV-1) is a potent activator of long terminal repeat-directed transcription.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
17	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
21	repeat	repeat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4922
# text = While in most cell types, activation requires interaction of Tat with the unusual transcription element TAR, astrocytic glial cells support TAR-independent transactivation of HIV-1 transcription by Tat.
1	While	while	SCONJ	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	astrocytic	astrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	TAR	Tar	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
26	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4923
# text = This alternative pathway of Tat activation is mediated by the viral enhancer, a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B (NF-kappa B) present in many cell types, including T lymphocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
23	form	form	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4924
# text = Tat transactivation mediated by the kappa B domain is sufficient to allow replication of TAR-deleted mutant HIV-1 in astrocytes.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
13	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TAR	TAR	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
19	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4925
# text = The present study demonstrates the existence of kappa B-specific binding factors present in human glial astrocytes that differ from prototypical NF-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
17	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4926
# text = The novel astrocyte-derived kappa B-binding activity is retained on an HIV-1
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	astrocyte	astrocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 4927
# text = Tat affinity column, while prototypical NF-kappa B from Jurkat T cells is not.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
3	column	column	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	while	while	SCONJ	IN	_	_	_	_	_
6	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4928
# text = In vitro transcription studies demonstrate that astrocyte-derived kappa B-binding factors activate transcription of the HIV-1 long terminal repeat and that this activation is dependent on the kappa B domain.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	astrocyte	astrocyte	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
22	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
23	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4929
# text = Moreover, TAR-independent transactivation of HIV-1 transcription is reproduced in vitro in an astrocyte factor-dependent manner which correlates with kappa B-binding activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TAR	TAR	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	reproduced	reproduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	astrocyte	astrocyte	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4930
# text = The importance of the central nervous system-enriched kappa B transcription factor in the regulation of HIV-1 expression is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4931
# text = Document 003001366 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001366	003001366	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4932
# text = Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	downregulates	downregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4933
# text = BACKGROUND: IL-5 controls development of eosinophilia and has been shown to be involved in the pathogenesis of allergic diseases.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
7	development	development	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
22	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4934
# text = In both atopic and nonatopic asthma, elevated IL-5 has been detected in peripheral blood and the airways.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	airways	airway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4935
# text = IL-5 is produced mainly by activated T cells, and its expression is regulated at the transcriptional level.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	mainly	mainly	ADV	RB	_	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4936
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4937
# text = This study focuses on the functional analysis of the human IL-5 (hIL-5) promoter and characterization of cis -regulatory elements and transcription factors involved in the suppression of IL-5 transcription in T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	focuses	focus	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	5	5	NUM	CD	NumType=Card	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4938
# text = METHODS: Methods used in this study include DNase I footprint assays, electrophoretic mobility shift assays, and functional analysis by mammalian cell transfection involving deletion analysis and site-directed mutagenesis.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Methods	method	NOUN	NNS	Number=Plur	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	study	study	NOUN	NN	Number=Sing	_	_	_	_
8	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	footprint	footprint	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
15	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
26	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
27	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
28	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4939
# text = RESULTS: We identified 5 protein binding regions (BRs) located within the proximal hIL-5 promoter.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	BRs	BRs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4940
# text = Functional analysis indicates that the BRs are involved in control of hIL-5 promoter activity.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	BRs	BR	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	hIL	hIL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4941
# text = Two of these regions, BR3 and BR4 located at positions -102 to -73, have not previously been described as regulators of IL-5 expression in T cells.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	BR3	BR3	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	BR4	BR4	NUM	CD	NumType=Card	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	102	102	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	73	73	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	5	5	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4942
# text = We show that the BR3 sequence contains a novel negative regulatory element located at positions -90 to -79 of the hIL-5 promoter, which binds Oct1, octamer-like, and YY1 nuclear factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BR3	BR3	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	90	90	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	79	79	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	like	like	INTJ	UH	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4943
# text = Substitution mutations, which abolished binding of these proteins to the BR3 sequence, significantly increased hIL-5 promoter activity in activated T cells.
1	Substitution	Substitution	NOUN	NN	Number=Sing	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	BR3	BR3	NOUN	NN	Number=Sing	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4944
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4945
# text = We suggest that Oct1, YY1, and octamer-like factors binding to the -90/-79 sequence within the proximal IL-5 promoter are involved in suppression of IL-5 transcription in T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Oct1	oct1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	YY1	yy1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	SCONJ	IN	_	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	90/-79	90/-79	NUM	CD	NumType=Card	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	5	5	NUM	CD	NumType=Card	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4946
# text = Document 003001367 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001367	003001367	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4947
# text = The role of BSAP (Pax-5) in B-cell development.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Pax	Pax	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4948
# text = The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	hierarchy	hierarchy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	control	control	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4949
# text = In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	paired	paire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
34	lymphopoiesis	lymphopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4950
# text = Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
3	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
15	switching	switching	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
21	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
27	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4951
# text = Document 003001368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001368	003001368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4952
# text = Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene [published erratum appears in Mol Cell Biol 1997 Apr;17(4):2351]
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
6	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
27	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Mol	Mol	PROPN	NNP	Number=Sing	_	_	_	_
30	Cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
31	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
32	1997	1997	NUM	CD	NumType=Card	_	_	_	_
33	Apr;17	Apr;17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	:2351	:2351	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4953
# text = The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is a key regulator of lymphocyte proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4954
# text = IL-2R alpha is rapidly and potently induced in T cells in response to mitogenic stimuli.
1	IL	Il	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	rapidly	rapidly	ADV	RB	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	potently	potently	ADV	RB	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4955
# text = Interleukin 2 (IL-2) stimulates IL-2R alpha transcription, thereby amplifying expression of its own high-affinity receptor.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	R	r	X	GW	_	_	_	_	_
13	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	thereby	thereby	ADV	RB	_	_	_	_	_
17	amplifying	amplify	VERB	VBG	VerbForm=Ger	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4956
# text = IL-2R alpha transcription is at least in part controlled by two positive regulatory regions, PRRI and PRRII.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2R	2r	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	part	part	NOUN	NN	Number=Sing	_	_	_	_
11	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	PRRI	PRRI	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	PRRII	PRRII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4957
# text = PRRI is an inducible proximal enhancer, located between nucleotides -276 and -244, which contains NF-kappaB and SRE/CArG motifs.
1	PRRI	PRRI	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	276	276	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	244	244	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
26	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4958
# text = PRRII is a T-cell-specific enhancer, located between nucleotides -137 and -64, which binds the T-cell-specific Ets protein Elf-1 and HMG-I(Y) proteins.
1	PRRII	pRRIi	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	137	137	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	64	64	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
27	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
28	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	Y	y	ADV	WRB	PronType=Int	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4959
# text = However, none of these proximal regions account for the induction of IL-2R alpha transcription by IL-2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	none	none	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
8	account	account	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4960
# text = To find new regulatory regions of the IL-2R alpha gene, 8.5 kb of the 5' end noncoding sequence of the IL-2R alpha gene have been sequenced.
1	To	to	PART	TO	_	_	_	_	_
2	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
3	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	8.5	8.5	NUM	CD	NumType=Card	_	_	_	_
15	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	_
20	end	end	NOUN	NN	Number=Sing	_	_	_	_
21	noncoding	noncoding	NOUN	NN	Number=Sing	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4961
# text = We identified an 86-nucleotide fragment that is 90% identical to the recently characterized murine IL-2-responsive element (mIL-2rE).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
7	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	recently	recently	ADV	RB	_	_	_	_	_
16	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	mIL	mil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2rE	2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4962
# text = This putative human IL-2rE, designated PRRIII, confers IL-2 responsiveness on a heterologous promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2rE	2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	PRRIII	pRRIIi	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4963
# text = PRRIII contains a Stat protein binding site that overlaps with an EBS motif (GASd/EBSd).
1	PRRIII	Prriii	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GASd/EBSd	GASd/EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4964
# text = These are essential for IL-2 inducibility of PRRIII/CAT reporter constructs.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	PRRIII	PRRIII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4965
# text = IL-2 induced the binding of Stat5a and b proteins to the human GASd element.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	b	b	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	GASd	Gasd	PROPN	NNP	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4966
# text = To confirm the physiological relevance of these findings, we carried out in vivo footprinting experiments which showed that stimulation of IL-2R alpha expression correlated with occupancy of the GASd element.
1	To	to	PART	TO	_	_	_	_	_
2	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
5	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	out	out	ADP	RP	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
16	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GASd	GAS	PROPN	NNP	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4967
# text = Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GASd/EBSd	GASd/EBSd	PROPN	NNP	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4968
# text = Document 003001369 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001369	003001369	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4969
# text = Identification of an inducible regulator of c-myb expression during T-cell activation.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4970
# text = Resting T cells express very low levels of c-Myb protein.
1	Resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	NOUN	NNS	Number=Plur	_	_	_	_
5	very	very	ADV	RB	_	_	_	_	_
6	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4971
# text = During T-cell activation, c-myb expression is induced and much of the increase in expression occurs at the transcriptional level.
1	During	during	ADP	IN	_	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induced	induced	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4972
# text = We identified a region of the c-myb 5' flanking sequence that increased c-myb expression during T-cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4973
# text = In vivo footprinting by ligation-mediated PCR was performed to correlate in vivo protein binding with functional activity.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	footprinting	footprinting	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	PCR	Pcr	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4974
# text = A protein footprint was visible over this region of the c-myb 5' flanking sequence in activated T cells but not in unactivated T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	visible	visible	ADJ	JJ	Degree=Pos	_	_	_	_
6	over	over	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4975
# text = An electrophoretic mobility shift assay (EMSA) with nuclear extract from activated T cells and an oligonucleotide of this binding site demonstrated a new protein-DNA complex, referred to as CMAT for c-myb in activated T cells; this complex was not present in unactivated T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	CMAT	CMAT	PROPN	NNP	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
40	T	T	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
45	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
46	not	not	PART	RB	_	_	_	_	_
47	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
50	T	T	PROPN	NNP	Number=Sing	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4976
# text = Because the binding site showed some sequence similarity with the nuclear factor of activated T cells (NFAT) binding site, we compared the kinetics of induction of the two binding complexes and the molecular masses of the two proteins.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	some	some	DET	DT	_	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
37	masses	mass	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	two	two	NUM	CD	NumType=Card	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4977
# text = Studies of the kinetics of induction showed that the NFAT EMSA binding complex appeared earlier than the CMAT complex.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
11	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	complex	complex	NUM	CD	NumType=Card	_	_	_	_
14	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CMAT	Cmat	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4978
# text = The NFAT protein migrated more slowly in a sodium dodecyl sulfate-polyacrylamide gel than the CMAT protein did.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	migrated	migrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	more	more	ADV	RBR	_	_	_	_	_
6	slowly	slowly	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
10	dodecyl	dodecyl	NOUN	NN	Number=Sing	_	_	_	_
11	sulfate-	sulfate-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
13	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CMAT	CMAT	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4979
# text = In addition, an antibody against NFAT did not cross-react with the CMAT protein.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	cross-react	cross-react	VERB	VB	VerbForm=Inf	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CMAT	Cmat	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4980
# text = The appearance of the CMAT binding complex was inhibited by both cyclosporin A and rapamycin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CMAT	CMAT	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
13	A	a	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4981
# text = The CMAT protein appears to be a novel inducible protein involved in the regulation of c-myb expression during T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CMAT	Cmat	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4982
# text = Document 003001370 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001370	003001370	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4983
# text = Unicellular-unilineage erythropoietic cultures: molecular analysis of regulatory gene expression at sibling cell level.
1	Unicellular	Unicelular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	unilineage	unilineage	ADJ	JJ	Degree=Pos	_	_	_	_
4	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	SCONJ	IN	_	_	_	_	_
14	sibling	sibl	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4984
# text = In vitro studies on hematopoietic control mechanisms have been hampered by the heterogeneity of the analyzed cell populations, ie, lack of lineage specificity and developmental stage homogeneity of progenitor/precursor cells growing in culture.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
6	control	control	NOUN	NN	Number=Sing	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	hampered	hamper	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterogeneity	heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
25	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
28	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
29	homogeneity	homogeneity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4985
# text = We developed unicellular culture systems for unilineage differentiation of purified hematopoietic progenitor cells followed by daughter cell analysis at cellular and molecular level.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	unicellular	unicellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
5	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	unilineage	unilineage	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	daughter	daughter	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4986
# text = In the culture system reported here, (1) the growth factor (GF) stimulus induces cord blood (CB) progenitor cells to proliferate and differentiate/mature exclusively along the erythroid lineage; (2) this erythropoietic wave is characterized by less than 4% apoptotic cells; (3) asymmetric divisions are virtually absent, ie, nonresponsive hematopoietic progenitors with no erythropoietic potential are forced into apoptosis; (4) the system is cell division controlled (cdc), ie, the number of divisions performed by each cell is monitored.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GF	gf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CB	CB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	differentiate	differentiate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
32	exclusively	exclusively	ADV	RB	_	_	_	_	_
33	along	along	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
36	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
43	wave	wave	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
48	than	than	ADP	IN	_	_	_	_	_
49	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	%	%	SYM	NN	Number=Sing	_	_	_	_
51	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	;	;	PUNCT	,	_	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	3	3	X	LS	_	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	asymmetric	asymmetric	ADJ	JJ	Degree=Pos	_	_	_	_
58	divisions	division	NOUN	NNS	Number=Plur	_	_	_	_
59	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
60	virtually	virtually	ADV	RB	_	_	_	_	_
61	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	nonresponsive	nonresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
66	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
67	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
68	with	with	ADP	IN	_	_	_	_	_
69	no	no	DET	DT	_	_	_	_	_
70	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
71	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
72	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
73	forced	force	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
74	into	into	ADP	IN	_	_	_	_	_
75	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	;	;	PUNCT	,	_	_	_	_	_
77	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
78	4	4	X	LS	_	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	_
80	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
81	system	system	NOUN	NN	Number=Sing	_	_	_	_
82	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
83	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
84	division	division	NOUN	NN	Number=Sing	_	_	_	_
85	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
86	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
87	cdc	cdc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
89	,	,	PUNCT	,	_	_	_	_	_
90	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
91	,	,	PUNCT	,	_	_	_	_	_
92	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
93	number	number	NOUN	NN	Number=Sing	_	_	_	_
94	of	of	ADP	IN	_	_	_	_	_
95	divisions	division	NOUN	NNS	Number=Plur	_	_	_	_
96	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
97	by	by	ADP	IN	_	_	_	_	_
98	each	each	DET	DT	_	_	_	_	_
99	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
100	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
101	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
102	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4987
# text = Single-cell reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was applied to this culture system to investigate gene expression of diverse receptors, markers of differentiation, and transcription factors (EKLF, GATA-1, GATA-2, p45 NF-E2, PU.1, and SCL/Tal1) at discrete stages of erythropoietic development.
1	Single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
5	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RT-PCR	RT-PCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
19	system	system	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	p45	p45	NUM	CD	NumType=Card	_	_	_	_
47	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
56	Tal1	Tal1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	_
58	at	at	ADP	IN	_	_	_	_	_
59	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
60	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
63	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4988
# text = Freshly isolated CD34(+) cells expressed CD34, c-kit, PU.1, and GATA-2 but did not express CD36, erythropoietin receptor (EpoR), SCL/Tal1, EKLF, NF-E2, GATA-1, or glyocophorin A (GPA).
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	+)	+)	PUNCT	-RRB-	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	CD34	Cd34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	kit	kit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
23	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/Tal1	/Tal1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	glyocophorin	glyocophorin	NOUN	NN	Number=Sing	_	_	_	_
46	A	A	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	GPA	gpa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4989
# text = In early to intermediate stages of erythroid differentiation we monitored the induction of CD36, Tal1, EKLF, NF-E2, and GATA-1 that preceeded expression of EpoR.
1	In	in	ADP	IN	_	_	_	_	_
2	early	early	ADV	RB	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Tal1	Tal1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	preceeded	proceeed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4990
# text = In late stages of erythroid maturation, GPA was upregulated, whereas CD34, c-kit, PU.1, and GATA-2 were barely or not detected.
1	In	in	ADP	IN	_	_	_	_	_
2	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
3	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	GPA	gpa	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	kit	kit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	barely	barely	ADV	RB	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4991
# text = In addition, competitive single-cell RT-PCR was used to assay CD34 mRNA transcripts in sibling CD34(+) CD38(-) cells differentiating in unilineage erythroid cultures: this analysis allowed us to semiquantitate the gradual downmodulation of CD34 mRNA from progenitor cells through their differentiating erythroid progeny.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
5	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	assay	assay	VERB	VB	VerbForm=Inf	_	_	_	_
15	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	34	34	NUM	CD	NumType=Card	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	SCONJ	IN	_	_	_	_	_
20	sibling	sibl	VERB	VBG	VerbForm=Ger	_	_	_	_
21	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	+)	+)	SYM	NFP	_	_	_	_	_
24	CD38	CD38	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(-)	(-)	PUNCT	.	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	unilineage	unilineage	ADJ	JJ	Degree=Pos	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	:	:	PUNCT	:	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
35	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	semiquantitate	semiquantitate	VERB	VB	VerbForm=Inf	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	gradual	gradual	ADJ	JJ	Degree=Pos	_	_	_	_
41	downmodulation	downmodulation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	34	34	NUM	CD	NumType=Card	_	_	_	_
45	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
46	from	from	ADP	IN	_	_	_	_	_
47	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	through	through	ADP	IN	_	_	_	_	_
50	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
51	differentiating	differentiat	NOUN	NN	Number=Sing	_	_	_	_
52	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
53	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4992
# text = It is concluded that this novel culture system, coupled with single-cell RT-PCR analysis, may eliminate the ambiguities intrinsic to molecular studies on heterogeneous populations of hematopoietic progenitors/precursors growing in culture, particularly in the initial stages of development.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	eliminate	eliminate	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ambiguities	ambiguity	NOUN	NNS	Number=Plur	_	_	_	_
24	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
30	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
33	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
36	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	particularly	particularly	ADV	RB	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
44	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4993
# text = Document 003001371 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001371	003001371	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4994
# text = Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha:
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor-kappaB	factor-kappab	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	8	8	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
13	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4995
# text = evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
1	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
5	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	activating	activate	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4996
# text = Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pluripotent	pluripotent	ADJ	JJ	Degree=Pos	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4997
# text = This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CXC	CXC	PROPN	NNP	Number=Sing	_	_	_	_
15	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4998
# text = In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ROS	Ros	X	ADD	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	INTJ	UH	_	_	_	_	SpaceAfter=No
29	"	"	PUNCT	``	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	histiocytic	histiocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4999
# text = TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5000
# text = In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
26	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	8	8	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5001
# text = TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
6	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	65	65	NUM	CD	NumType=Card	_	_	_	_
10	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5002
# text = A, whose binding in the nucleus occurs before changes in intracellular ROS.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	ADJ	JJ	Degree=Pos	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5003
# text = Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	or	or	CCONJ	CC	_	_	_	_	_
4	up	up	ADV	RB	_	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	15	15	NUM	CD	NumType=Card	_	_	_	_
7	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
8	posttreatment	posttreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	relative	relative	ADV	RB	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
16	dimethyl	dimethyl	NOUN	NN	Number=Sing	_	_	_	_
17	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	vol	vol	INTJ	UH	_	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	vol	vol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
31	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	%	%	SYM	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5004
# text = Surprisingly, however, DMSO has no effect on inducible Rel A binding.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5005
# text = Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	unrelated	unrelated	ADJ	JJ	Degree=Pos	_	_	_	_
14	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	vitamin	vitamin	PROPN	NNP	Number=Sing	_	_	_	_
23	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5006
# text = These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
9	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	separable	separable	ADJ	JJ	Degree=Pos	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5007
# text = Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
7	yield	yield	VERB	VB	VerbForm=Inf	_	_	_	_
8	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
9	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
12	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
15	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5008
# text = Document 003001372 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001372	003001372	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5009
# text = Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
1	Epithelial	Epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
6	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
13	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	amebic	amebic	ADJ	JJ	Degree=Pos	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	intestine	intestine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5010
# text = BACKGROUND & AIMS: Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
1	BACKGROUND	background	PROPN	NNP	Number=Sing	_	_	_	_
2	&	&	CCONJ	CC	_	_	_	_	_
3	AIMS	aim	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Entamoeba	Entamoeba	PROPN	NNP	Number=Sing	_	_	_	_
6	histolytica	histolytica	NOUN	NN	Number=Sing	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	intestine	intestine	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
14	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
15	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5011
# text = The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aims	aim	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	were	be	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	host	host	ADV	RBS	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	amebiasis	amebiasis	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
29	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	initiating	initiat	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5012
# text = METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
4	histolytica	histolytican	NOUN	NN	Number=Sing	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
11	xenografts	xenograft	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
14	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	immunodeficient	immunodeficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	SCID	Scid	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	INT	INT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5013
# text = Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	amebic	amebic	ADJ	JJ	Degree=Pos	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	intraluminal	intraluminal	ADJ	JJ	Degree=Pos	_	_	_	_
15	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
19	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
24	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
37	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
38	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	amebiasis	amebiasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	by	by	SCONJ	IN	_	_	_	_	_
44	depleting	deplet	VERB	VBG	VerbForm=Ger	_	_	_	_
45	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
46	from	from	ADP	IN	_	_	_	_	_
47	SCID	SCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	INT	Int	ADJ	JJ	Degree=Pos	_	_	_	_
52	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5014
# text = RESULTS:
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5015
# text = Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
5	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
6	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
16	8	8	NUM	CD	NumType=Card	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
19	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
24	influx	influx	NOUN	NN	Number=Sing	_	_	_	_
25	into	into	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5016
# text = histolytica-infected intestinal xenografts.
1	histolytica	histolytican	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
2	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
4	xenografts	xenograft	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5017
# text = Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU- INT mice blocked the increase in intestinal permeability observed with amebic infection.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	gut	gut	ADJ	JJ	Degree=Pos	_	_	_	_
5	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
10	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	SCID	SCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	_
21	INT	Int	PROPN	NNP	Number=Sing	_	_	_	_
22	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
23	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
28	permeability	permeability	NOUN	NN	Number=Sing	_	_	_	_
29	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	amebic	amebic	ADJ	JJ	Degree=Pos	_	_	_	_
32	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5018
# text = CONCLUSIONS: Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Intestinal	Intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
4	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	initiate	initiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	SCONJ	IN	_	_	_	_	_
11	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
12	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
16	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
21	histolytica	histolytica	PROPN	NNP	Number=Sing	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	SCONJ	IN	_	_	_	_	_
31	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5019
# text = Document 003001373 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001373	003001373	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5020
# text = A novel heterodimerization partner for thyroid hormone receptor.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	_
4	partner	partner	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5021
# text = Peroxisome proliferator-activated receptor.
1	Peroxisome	Peroxisome	NOUN	NN	Number=Sing	_	_	_	_
2	proliferator-	proliferator-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5022
# text = Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors.
1	Retinoid	Retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
5	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
14	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5023
# text = In this study we have identified the peroxisome proliferator-activated receptor (PPAR) as a new thyroid hormone receptor (THR) auxiliary nuclear protein, heterodimerizing with THR in solution.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	peroxisome	peroxisome	ADJ	JJ	Degree=Pos	_	_	_	_
9	proliferator-	proliferator-	X	AFX	_	_	_	_	SpaceAfter=No
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PPAR	PPAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
18	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
19	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	THR	Thr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	auxiliary	auxiliary	ADJ	JJ	Degree=Pos	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	heterodimerizing	heterodimerize	VERB	VBG	VerbForm=Ger	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	solution	solution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5024
# text = Although these heterodimers do not recognize a classical thyroid hormone response element (TRE) characterized by direct repeat separated by four nucleotides (DR+4), PPAR behaves as a dominant negative regulator of thyroid hormone (TH) action.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
4	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	recognize	recognize	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
9	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
10	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
19	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
20	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	four	four	NUM	CD	NumType=Card	_	_	_	_
23	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	PPAR	PPAR	PROPN	NNP	Number=Sing	_	_	_	_
31	behaves	behave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
35	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
39	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TH	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5025
# text = However, a TH-dependent positive effect is elicited by selective interaction of the THR beta-PPAR but not the THR alpha-PPAR heterodimer with a novel TRE (DR+2).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	TH	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	THR	Thr	PROPN	NNP	Number=Sing	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	PPAR	Ppar	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	PPAR	Ppar	NOUN	NN	Number=Sing	_	_	_	_
27	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
31	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	DR	dr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5026
# text = The critical region of THR beta was mapped to 3 amino acids in the distal box of the DNA binding domain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	amino	amino	DET	DT	_	_	_	_	_
12	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
16	box	box	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5027
# text = Hence, PPAR can positively or negatively influence TH action depending on TRE structure and THR isotype.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PPAR	PPAR	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	positively	positively	ADV	RB	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	negatively	negatively	ADV	RB	_	_	_	_	_
8	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
9	TH	th	NOUN	NN	Number=Sing	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
17	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5028
# text = Document 003001374 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001374	003001374	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5029
# text = Induction of CIITA and modification of in vivo HLA-DR promoter occupancy in normal thymic epithelial cells treated with IFN-gamma: similarities and distinctions with respect to HLA-DR-constitutive B cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
9	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
17	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	:	:	PUNCT	:	_	_	_	_	_
25	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	distinctions	distinction	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	DR-	DR-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5030
# text = In this study, the IFN-gamma induction of MHC class II gene expression in primary cultures of thymic epithelial cells (TEC) was analyzed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
18	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
21	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TEC	TEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5031
# text = This cellular system offers the advantage that MHC class II induction is studied in a "physiologic" cell lineage that, as a result of this expression within the thymus, is thought to participate to the selection and maturation of the T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	_
4	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
17	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	"	"	PUNCT	''	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	result	result	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	within	within	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5032
# text = It was found that the MHC class II gene expression was associated with the de novo transcription of the gene encoding the CIITA trans-activator, a crucial MHC class II gene regulatory factor.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	de	de	NOUN	NN	Number=Sing	_	_	_	_
16	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
24	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
30	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5033
# text = Furthermore, the anatomy of interaction between the MHC class II DRA promoter and corresponding binding factors was analyzed by in vivo DNAse I footprint.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	anatomy	anatomy	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	corresponding	correspond	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
23	DNAse	DNAse	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	footprint	footprint	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5034
# text = It was found that treatment with IFN-gamma induces changes in the occupancy of the DRA gene regulatory sequences by nuclear factors.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
19	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5035
# text = The resulting occupancy displays strong similarities with the one observed in the MHC class II-constitutive B cells, represented by both the Burkitt lymphoma line Raji and normal tonsil- derived B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
3	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
4	displays	display	NOUN	NNS	Number=Plur	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	one	one	NOUN	NN	Number=Sing	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	_
28	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	tonsil	tonsil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5036
# text = However, some peculiar differences were observed between the TEC, either IFN-gamma-induced or not, and the constitutive B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	some	some	DET	DT	_	_	_	_	_
4	peculiar	peculiar	ADJ	JJ	Degree=Pos	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TEC	Tec	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	IFN-gamma	IFN-gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	not	not	PART	RB	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5037
# text = These results suggest that both common mechanisms, such as the one mediated by the CIITA trans-activator, and distinct tissue-specific constraints contribute to the transcriptional control of constitutive and IFN-gamma-induced MHC class II gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	one	one	NOUN	NN	Number=Sing	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
17	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	tissue-	tissue-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	constraints	constraint	NOUN	NNS	Number=Plur	_	_	_	_
26	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	IFN-	IFN-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
39	class	class	NOUN	NN	Number=Sing	_	_	_	_
40	II	ii	NUM	CD	NumType=Card	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5038
# text = Document 003001375 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001375	003001375	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5039
# text = Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	_
14	chimeras	chimera	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5040
# text = Giant cell arteritis (GCA) is a vasculitic syndrome that preferentially affects medium and large-sized arteries.
1	Giant	giant	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GCA	GCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	vasculitic	vasculitic	ADJ	JJ	Degree=Pos	_	_	_	_
10	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	preferentially	preferentially	ADV	RB	_	_	_	_	_
13	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	large	large	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sized	size	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	arteries	artery	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5041
# text = Glucocorticoid therapy resolves clinical symptoms within hours to days, but therapy has to be continued over several years to prevent disease relapses.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
3	resolves	resolf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	continued	continue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	over	over	ADP	IN	_	_	_	_	_
18	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
19	years	year	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
23	relapses	relaps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5042
# text = It is not known whether and how glucocorticoids affect the function of the inflammatory infiltrate or why the disease persists subclinically despite chronic treatment.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
9	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	infiltrate	infiltrate	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	why	why	ADV	WRB	PronType=Int	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
20	persists	persist	NOUN	NNS	Number=Plur	_	_	_	_
21	subclinically	subclinically	ADV	RB	_	_	_	_	_
22	despite	despite	ADP	IN	_	_	_	_	_
23	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5043
# text = GCA is self-sustained in temporal arteries engrafted into SCID mice, providing a model in which the mechanisms of action and limitations of glucocorticoid therapy can be examined in vivo.
1	GCA	GCa	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
8	arteries	arteries	NOUN	NNS	Number=Plur	_	_	_	_
9	engrafted	engraft	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	_
12	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	model	model	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	action	action	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	limitations	limitation	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5044
# text = Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
6	artery	artery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	_
9	chimeras	chimera	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	wk	wk	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
16	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
29	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	_
44	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	diminished	diminished	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
53	NO	no	ADJ	JJ	Degree=Pos	_	_	_	_
54	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5045
# text = In contrast, synthesis of IFN-gamma mRNA was only slightly decreased, and expression of TGF-beta1 was unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	slightly	slightly	ADV	RB	_	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5046
# text = These findings correlated with activation of the IkappaBalpha gene and blockade of the nuclear translocation of NFkappaB in the xenotransplanted tissue.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	xenotransplanted	xenotransplant	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5047
# text = Dose-response experiments suggested that steroid doses currently used in clinical medicine are suboptimal in repressing NFkappaB-mediated cytokine production in the inflammatory lesions.
1	Dose	Dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
9	currently	currently	ADV	RB	_	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
13	medicine	medicine	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	suboptimal	suboptimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	repressing	repress	VERB	VBG	VerbForm=Ger	_	_	_	_
18	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5048
# text = Chronic steroid therapy was able to deplete the T cell products IL-2 and IFN-gamma, whereas the activation of tissue-infiltrating macrophages was only partially affected.
1	Chronic	Chronic	PROPN	NNP	Number=Sing	_	_	_	_
2	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	deplete	deplete	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	products	product	NOUN	NNS	Number=Plur	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	partially	partially	ADV	RB	_	_	_	_	_
30	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5049
# text = IL-1beta transcription was abrogated; in contrast, TGF-beta1 mRNA synthesis was steroid resistant.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	;	;	PUNCT	,	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5050
# text = The persistence of TGF-beta1-transcribing macrophages, despite paralysis of T cell function, may provide an explanation for the chronicity of the disease, and may identify a novel therapeutic target in this inflammatory vasculopathy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta1	beta1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	transcribing	transcribing	VERB	VBG	VerbForm=Ger	_	_	_	_
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	despite	despite	ADP	IN	_	_	_	_	_
12	paralysis	paralysis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	chronicity	chronicity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
34	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	target	target	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5051
# text = Document 003001376 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001376	003001376	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5052
# text = Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
3	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	alpha	alpha	ADP	IN	_	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
10	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5053
# text = The minimal region of the human tumor necrosis factor alpha (TNF-alpha) gene promoter necessary for its transcriptional induction by phorbol esters (PMA) in human T and B lymphocyte cell lines has been localized between -52 and +89 nucleotides (nt) relative to the gene's transcriptional start site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
25	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
34	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
37	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	between	between	ADP	IN	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	52	52	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
45	89	89	NUM	CD	NumType=Card	_	_	_	_
46	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	nt	not	PART	RB	_	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	relative	relative	ADV	RB	_	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	's	's	PART	POS	_	_	_	_	_
55	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
56	start	start	NOUN	NN	Number=Sing	_	_	_	_
57	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5054
# text = Comparison of these sequences to those required to mediate virus or lipopolysaccharide (LPS) induction of the gene reveal significant differences, and thus, the sequence requirements for PMA induction are distinct from those that mediate induction by virus or LPS.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	differences	difference	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
32	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
37	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
39	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5055
# text = Although three sites in the TNF-alpha promoter (kappa 1, kappa 2, and kappa 3) specifically bind the transcription factor NF-kappa B in lymphoid nuclear extracts, TNF-alpha mRNA induction by PMA does not correlate with NF-kappa B binding activities displayed by different T and B cell lines.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	3	3	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	specifically	specifically	ADV	RB	_	_	_	_	_
22	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
39	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
42	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
49	B	b	NOUN	NN	Number=Sing	_	_	_	_
50	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
51	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
52	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
55	T	T	PROPN	NNP	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5056
# text = Moreover, kappa 1-kappa 3 can each be deleted from the TNF-alpha promoter with little effect on the gene's inducibility by PMA.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	each	each	DET	DT	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5057
# text = Therefore, TNF-alpha mRNA induction by PMA, like its induction by virus and LPS, is not primarily mediated by NF-kappa B, but rather is mediated through other sequences and protein factors.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
6	mRNA	mRNA	X	GW	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	like	like	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	primarily	primarily	ADV	RB	_	_	_	_	_
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	rather	rather	ADV	RB	_	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5058
# text = Surprisingly, multimers of kappa 1-kappa 3 can confer PMA inducibility on a heterologous promoter in a B (Raji), but not a T (HUT78) cell line.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	multimers	multimer	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	T	T	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	HUT78	HUT78	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5059
# text = However they are not functional on a truncated TNF-alpha promoter, indicating that promoter context and cell type specificity influence the PMA inducible function of these NF-kappa B binding sites.
1	However	however	ADV	RB	_	_	_	_	_
2	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	context	context	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
22	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5060
# text = Document 003001377 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001377	003001377	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5061
# text = Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5062
# text = CTCF is a transcriptional repressor of the c-myc gene.
1	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5063
# text = Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	some	some	DET	DT	_	_	_	_	_
8	detail	detail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	there	there	PRON	EX	_	_	_	_	_
11	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	very	very	ADV	RB	_	_	_	_	_
13	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
14	information	information	NOUN	NN	Number=Sing	_	_	_	_
15	about	about	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CTCF	CTCF	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5064
# text = Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5065
# text = We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	i	i	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	CTCF	CTCF	ADP	IN	_	_	_	_	_
30	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	retarded	retarded	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
37	pronounced	pronounce	ADJ	JJ	Degree=Pos	_	_	_	_
38	than	than	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	CTCF	Ctcf	NOUN	NN	Number=Sing	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	differentially	differentially	ADV	RB	_	_	_	_	_
50	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
54	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
55	depend	depend	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	on	on	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
59	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5066
# text = We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	concluded	conclude	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	post-transcriptional	post-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5067
# text = Document 003001378 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001378	003001378	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5068
# text = Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	class	class	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
16	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
18	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-13	-13	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	divergent	divergent	NOUN	NN	Number=Sing	_	_	_	_
26	X2	x2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5069
# text = We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Clone	Clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	DP.	DP.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5070
# text = Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	criteria	criterion	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5071
# text = Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
4	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	operates	operate	NOUN	NNS	Number=Plur	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	141	141	NUM	CD	NumType=Card	_	_	_	_
27	base	base	NOUN	NN	Number=Sing	_	_	_	_
28	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5072
# text = A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	series	series	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
5	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	DQB	Dqb	PROPN	NNP	Number=Sing	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	further	further	ADV	RB	_	_	_	_	_
14	map	map	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
17	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5073
# text = Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
1	Insertion	Insertion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	oligonucleotides	oligonucleotides	NOUN	NNS	Number=Plur	_	_	_	_
4	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
7	X	x	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DQB	DQB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	W	W	ADJ	JJ	Degree=Pos	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
21	Y-	y-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	141	141	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
31	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
32	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
33	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	nearly	nearly	ADV	RB	_	_	_	_	_
37	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	type	type	NOUN	NN	Number=Sing	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5074
# text = Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
1	Substitution	Substitution	NOUN	NN	Number=Sing	_	_	_	_
2	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	where	where	ADV	WRB	PronType=Int	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
9	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	X1	X1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	boxes	boxe	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
31	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5075
# text = The DQB X2-box was able to restore expression to the silent DRA reporter construct.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DQB	DQB	NOUN	NN	Number=Sing	_	_	_	_
3	X2	x2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
14	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5076
# text = Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
7	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
13	X2	X2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	box	box	NOUN	NN	Number=Sing	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5077
# text = None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
1	None	none	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hybrid	hybrid	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DR/-	Dr/-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
21	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
22	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Jijoye	Jijoye	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5078
# text = These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
7	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
18	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
24	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	isotypes	isotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5079
# text = Document 003001379 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001379	003001379	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5080
# text = Multiple transcription factors are required for activation of human interleukin 9 gene in T cells.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5081
# text = The genetic elements and regulatory mechanisms responsible for human interleukin 9 (IL-9) gene expression in a human T cell leukemia virus type I-transformed human T cell line, C5MJ2, were investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	type	type	NOUN	NN	Number=Sing	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
28	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
29	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	C5MJ2	C5mj2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5082
# text = We demonstrated that IL-9 gene expression is controlled, at least in part, by transcriptional activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	9	9	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5083
# text = Transient expression of the luciferase reporter gene linked to serially deleted sequences of the 5'-flanking region of the IL-9 gene has revealed several positive and negative regulatory elements involved in the basal and inducible expression of the IL-9 gene in C5MJ2 cells.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	luciferase	luciferase	ADJ	JJ	Degree=Pos	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	serially	serially	ADV	RB	_	_	_	_	_
11	deleted	delete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
19	region	region	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	9	9	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
34	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	9	9	NUM	CD	NumType=Card	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	C5MJ2	C5MJ2	NUM	CD	NumType=Card	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5084
# text = An AP-1 site at -146 to -140 was shown to be involved in the expression of the IL-9 gene.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	146	146	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	140	140	NUM	CD	NumType=Card	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	9	9	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5085
# text = A proximal region between -46 and -80 was identified as the minimum sequence for the basal and inducible expression of the IL-9 gene in C5MJ2 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	-46	-46	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	80	80	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	minimum	minimum	ADJ	JJ	Degree=Pos	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	9	9	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	C5MJ2	C5MJ2	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5086
# text = Within this region, an NF-kappaB site at -59 to -50 and its adjacent 20-base pair upstream sequence were demonstrated to play a critical role for the IL-9 promoter activity.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	59	59	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	50	50	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
19	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	base	base	NOUN	NN	Number=Sing	_	_	_	_
22	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
23	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	9	9	NUM	CD	NumType=Card	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5087
# text = DNA-protein binding studies indicated that NF-kappaB, c-Jun, and potentially novel proteins (around 35 kDa) can bind to this important sequence.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	potentially	potentially	ADV	RB	_	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	around	around	ADV	RB	_	_	_	_	_
21	35	35	NUM	CD	NumType=Card	_	_	_	_
22	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5088
# text = Mutations at different sites within this proximal promoter region abolished the promoter activity as well as the DNA binding.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5089
# text = Taken together, these results suggest that the cooperation of different transcription factors is essential for IL-9 gene expression in T cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	9	9	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5090
# text = Document 003001380 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001380	003001380	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5091
# text = AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.
1	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CB	Cb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	Falpha2	falpha2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	PAX5	PAX5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	BLK	Blk	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5092
# text = AML1 plays a critical role during hematopoiesis and chromosomal translocations involving AML1 are commonly associated with different forms of leukemia, including pre-B acute lymphoblastic leukemia.
1	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
2	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
10	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
11	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
12	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	commonly	commonly	ADV	RB	_	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
24	-B	-b	X	GW	_	_	_	_	_
25	acute	acute	X	ADD	_	_	_	_	_
26	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5093
# text = To understand the function of AML1 during B cell differentiation, we analyzed regulatory regions of B cell-specific genes for potential AML1-binding sites and have identified a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
24	AML1	Aml1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
33	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	blk	blk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5094
# text = Gel mobility shift assays and transient transfection assays demonstrate that AML1 binds specifically to this site in the blk promoter and this binding site is important for blk promoter activity.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
7	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	AML1	AML1	NUM	CD	NumType=Card	_	_	_	_
12	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	blk	blk	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	blk	blk	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5095
# text = Furthermore, in vitro binding analysis revealed that the AML1 runt DNA-binding domain physically interacts with the paired DNA-binding domain of BSAP, a B cell-specific transcription factor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
11	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	physically	physically	ADV	RB	_	_	_	_	_
17	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	paired	paire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5096
# text = BSAP has been shown previously to be important for B cell-specific regulation of the blk gene.
1	BSAP	Bsap	SYM	NFP	_	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	blk	blk	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5097
# text = Physical interaction of AML1 with BSAP correlates with functional cooperativity in transfection studies where AML1 and BSAP synergistically activate blk promoter transcription by more than 50-fold.
1	Physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
7	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
13	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
14	where	where	ADV	WRB	PronType=Rel	_	_	_	_
15	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	_
18	synergistically	synergistically	ADV	RB	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	blk	blk	NOUN	NN	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5098
# text = These results demonstrate physical and functional interactions between AML1 and BSAP and suggest that AML1 is an important factor for regulating a critical B cell-specific gene, blk.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	blk	blk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5099
# text = Document 003001381 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001381	003001381	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5100
# text = A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	shortened	shortened	ADJ	JJ	Degree=Pos	_	_	_	_
3	life	life	NOUN	NN	Number=Sing	_	_	_	_
4	span	span	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-/-	-/-	PUNCT	.	_	_	_	_	_
8	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
9	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	due	due	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	ameliorated	ameliorate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
28	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5101
# text = Using homologous recombination, both EKLF alleles in murine embryonic stem (ES) cells were inactivated.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
3	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	EKLF	Eklf	NOUN	NN	Number=Sing	_	_	_	_
7	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
10	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	ES	E	INTJ	UH	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	inactivated	inactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5102
# text = These EKLF-/- ES cells were capable of undergoing in vitro differentiation to form definitive erythroid colonies that were similar in size and number to those formed by wild-type ES cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	EKLF	EKLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-/-	-/-	PUNCT	.	_	_	_	_	_
4	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	SCONJ	IN	_	_	_	_	_
9	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
15	definitive	definitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	size	size	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	number	number	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
27	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	ES	e	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5103
# text = However, the EKLF-/- colonies were poorly hemoglobinized and enucleated erythrocytes in these colonies contained numerous Heinz bodies.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	EKLF	Eklf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-/-	-/-	PUNCT	.	_	_	_	_	_
6	colonies	coloney	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	poorly	poorly	ADV	RB	_	_	_	_	_
9	hemoglobinized	hemoglobinize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	enucleated	enucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
16	contained	containe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
18	Heinz	Heinz	NOUN	NN	Number=Sing	_	_	_	_
19	bodies	body	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5104
# text = Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that adult and embryonic globin genes were appropriately regulated, with the exception of beta h1-globin, which continued to be expressed at a very low level.
1	Reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
2	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
5	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
6	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RT-PCR	Rt-pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	appropriately	appropriately	ADV	RB	_	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
27	h1	h1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-globin	-globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	continued	continue	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	very	very	ADV	RB	_	_	_	_	_
38	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5105
# text = The ratio of adult beta-globin/alpha-globin mRNA in the mutant ES cells was 1/15 of that in wild-type ES cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-globin/	-globin/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	alpha-globin	alpha-globin	ADJ	JJ	Degree=Pos	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
12	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	1/15	1/15	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5106
# text = When the EKLF-/- cells were injected into blastocysts, they did not contribute at a detectable level to the mature erythrocyte compartment of the chimeric animals, based on analysis of glucose phosphate isomerase-1 (GPI-1) isozymes and hemoglobins that distinguish ES cell-derived erythrocytes from host blastocyst-derived erythrocytes.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	EKLF	EKLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-/-	-/-	PUNCT	.	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	injected	inject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	blastocysts	blastocyst	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
22	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
23	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
27	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	_
34	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
35	isomerase	isomerase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	GPI	GPI	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	isozymes	isozyme	NOUN	NNS	Number=Plur	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	hemoglobins	hemoglobin	NOUN	NNS	Number=Plur	_	_	_	_
46	that	that	PRON	WDT	PronType=Rel	_	_	_	_
47	distinguish	distinguish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	ES	ES	ADV	RB	_	_	_	_	_
49	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
53	from	from	ADP	IN	_	_	_	_	_
54	host	host	NOUN	NN	Number=Sing	_	_	_	_
55	blastocyst	blastocyst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5107
# text = In contrast, semiquantitative RT-PCR analysis of RNA from reticulocytes of the same chimeric animals suggested that the ES cell-derived reticulocytes were present at a level of 6% to 8%.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
5	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
17	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
18	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ES	ES	PROPN	NNPS	Number=Plur	_	_	_	_
22	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	8%	8%	X	XX	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5108
# text = This indicated that the EKLF-/- erythrocytes in adult animals must be short-lived, apparently due to the imbalance of beta- versus alpha-globin chains, leading to the precipitation of excess alpha-globin chains to form Heinz bodies.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	EKLF	EKLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	/-	/-	PUNCT	.	_	_	_	_	_
8	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
11	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
12	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-lived	-live	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	apparently	apparently	ADV	RB	_	_	_	_	_
18	due	due	ADP	IN	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	_
25	versus	versus	CCONJ	CC	_	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
29	chains	chains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	precipitation	precipitation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
40	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
43	Heinz	Heinz	PROPN	NNP	Number=Sing	_	_	_	_
44	bodies	body	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5109
# text = Consistent with this hypothesis, the short life span was ameliorated by introduction into the EKLF-/- ES cells of a human LCR/gamma-globin gene, as evidenced by the presence of ES cell-derived reticulocytes as well as mature erythrocytes in the blood of the chimeric animals.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
8	life	life	NOUN	NN	Number=Sing	_	_	_	_
9	span	span	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	ameliorated	ameliorate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	EKLF	Eklf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-/-	-/-	PUNCT	.	_	_	_	_	_
18	ES	E	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	LCR/	Lcr/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	ES	ES	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	as	as	ADV	RB	_	_	_	_	_
41	well	well	ADV	RB	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
44	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
51	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5110
# text = Document 003001382 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001382	003001382	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5111
# text = Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5112
# text = Two different proteins which independently bound to neighboring sequences within the negative regulatory element (NRE) of human immunodeficiency virus type 1 (HIV-1) were detected in the nuclear extract of a virus-infected human T cell line.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	independently	independently	ADV	RB	_	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	neighboring	neighbore	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	T	t	PROPN	NNP	Number=Sing	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5113
# text = One of the factors bound to a novel dyad symmetrical sequence.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	dyad	dyad	NOUN	NN	Number=Sing	_	_	_	_
10	symmetrical	symmetrical	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5114
# text = This sequence is well conserved in various HIV-1 isolates and partial homology was found with the promoter region of the human retinoblastoma gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
14	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5115
# text = Similar DNA binding activity was detected in a variety of virus-uninfected human T cell lines and HeLa cells by means of a gel mobility shift assay.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	uninfected	uninfect	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	means	means	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5116
# text = The other factor bound to a putative AP-1 recognition sequence predicted for the HIV-1 NRE.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	NRE	Nre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5117
# text = However, this factor did not bind to a typical AP-1 site.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5118
# text = The insertion of multiple copies of the binding site for the former or latter factor into a heterologous promoter reduced the promoter activity to one-tenth or one-third, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	tenth	tenth	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	third	third	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5119
# text = Thus, each factor may function as a novel negative regulator of transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	each	each	DET	DT	_	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5120
# text = Document 003001383 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001383	003001383	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5121
# text = E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.
1	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	_
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5122
# text = Retinoic acid (RA)-induced maturation mediated by the retinoic acid receptor alpha (RAR alpha) has been implicated in myeloid development.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
25	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5123
# text = We have used differential hybridization analysis of a cDNA library constructed from the murine RA-inducible MPRO promyelocyte cell line to identify immediate-early genes induced by RA during granulocytic differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
10	library	library	NOUN	NN	Number=Sing	_	_	_	_
11	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
15	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	MPRO	Mpro	NOUN	NN	Number=Sing	_	_	_	_
19	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
24	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
31	during	during	ADP	IN	_	_	_	_	_
32	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5124
# text = E3, one of nine sequences identified, was upregulated in an immediate-early manner, with transcript levels peaking after 60 minutes exposure to RA.
1	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nine	nine	NUM	CD	NumType=Card	_	_	_	_
6	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
25	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	RA.	RA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5125
# text = E3 transcripts were RA-inducible in HL60 cells, but not in an RA-resistant subclone, HL60R, that harbors a mutated RAR alpha gene.
1	E3	E3	NUM	CD	NumType=Card	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	RA	RA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
18	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	HL60R	Hl60r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	harbors	harbor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	ADP	IN	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5126
# text = However, when HL60R cells were transduced with a functional copy of the RAR alpha gene, RA induced a 10-fold increase in E3 mRNA levels.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	HL60R	Hl60r	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	ADP	IN	_	_	_	_	_
16	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
24	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	E3	E3	NUM	CD	NumType=Card	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5127
# text = E3 transcripts are present in the myeloid, B-lymphoid, and erythroid lineages, absent in nonhematopoietic cells, and encode a highly hydrophobic, potentially phosphorylated polypeptide of unknown function with significant homology to a putative protein expressed in myeloid cells.
1	E3	E3	NUM	CD	NumType=Card	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	absent	absent	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	encode	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	highly	highly	ADV	RB	_	_	_	_	_
26	hydrophobic	hydrophobic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	potentially	potentially	ADV	RB	_	_	_	_	_
29	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
33	function	function	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
36	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5128
# text = The murine E3 promoter harbors a single bipartite retinoic acid response element which in transient transfection assays conferred RA sensitivity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	E3	E3	NUM	CD	NumType=Card	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	harbors	harbor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
8	bipartite	bipartite	NOUN	NN	Number=Sing	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	conferred	confer	ADJ	JJ	Degree=Pos	_	_	_	_
19	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5129
# text = These results indicate that E3 is a hematopoietic-specific gene that is an immediate target for the activated RAR alpha during myelopoiesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
16	target	target	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	myelopoiesis.	myelopoiesis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5130
# text = Document 003001384 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001384	003001384	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5131
# text = Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
13	alone	alone	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	soluble	soluble	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-bound	-bound	ADP	IN	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5132
# text = The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	individual	individual	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5133
# text = Among host immune factors, the cytokine TNF-alpha has previously been shown to increase HIV-1 replication in various monocyte and T cell model systems.
1	Among	among	ADV	RB	Degree=Pos	_	_	_	_
2	host	host	ADV	RBS	_	_	_	_	_
3	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
17	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
27	model	model	NOUN	NN	Number=Sing	_	_	_	_
28	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5134
# text = Here, we demonstrate that signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR), also regulates HIV-1 replication.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	lymphotoxin-	lymphotoxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	betaR	betaR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	also	also	ADV	RB	_	_	_	_	_
30	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5135
# text = Furthermore, HIV-1 replication is cooperatively stimulated when the distinct LT-betaR and TNF receptor systems are simultaneously engaged by their specific ligands.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	betaR	betaR	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	TNF	TNF	SCONJ	IN	_	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
22	engaged	engage	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5136
# text = Moreover, in a physiological coculture cellular assay system, we show that membrane-bound TNF-alpha and LT-alpha1beta2 act virtually identically to their soluble forms in the regulation of HIV-1 replication.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	coculture	coculture	NOUN	NN	Number=Sing	_	_	_	_
7	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
8	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	LT-alpha1	LT-alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
23	act	act	NOUN	NN	Number=Sing	_	_	_	_
24	virtually	virtually	ADV	RB	_	_	_	_	_
25	identically	identically	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
29	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5137
# text = Thus, cosignaling via the LT-beta and TNF-alpha receptors is probably involved in the modulation of HIV-1 replication and the subsequent determination of HIV-1 viral burden in monocytes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cosignaling	cosignal	VERB	VBG	VerbForm=Ger	_	_	_	_
4	via	via	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	LT-	Lt-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	probably	probably	ADV	RB	_	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
27	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	burden	burden	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5138
# text = Intriguingly, surface expression of LT-alpha1beta2 is up-regulated on a T cell line acutely infected with HIV-1, suggesting a positive feedback loop between HIV-1 infection, LT-alpha1beta2 expression, and HIV-1 replication.
1	Intriguingly	Intriguingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	surface	surface	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	LT-	Lt-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	acutely	acutely	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
29	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	LT-	LT-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5139
# text = Given the critical role that LT-alpha1beta2 plays in lymphoid architecture, we speculate that LT-alpha1beta2 may be involved in HIV-associated abnormalities of the lymphoid organs.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	LT-alpha1	LT-alpha1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	beta2	beta2	PART	TO	Abbr=Yes	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	architecture	architecture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	LT-alpha1	LT-alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	beta2	beta2	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
28	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5140
# text = Document 003001385 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001385	003001385	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5141
# text = Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.
1	Calcium/calmodulin	Calcium/calmodulin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	downregulates	downregulate	NOUN	NNS	Number=Plur	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5142
# text = Engagement of the T cell receptor for antigen activates phospholipase C resulting in an increase in intracellular free calcium concentration ([Ca2+]i) and activation of protein kinase C (PKC).
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
10	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
11	C	class	PROPN	NNP	Number=Sing	_	_	_	_
12	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5143
# text = Increased [Ca2+]i activates Ca2+/calmodulin-dependent kinases including the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaM-K II), as well as calcineurin, a type 2B protein phosphatase.
1	Increased	increase	PROPN	NNP	Number=Sing	_	_	_	_
2	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
5	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	Ca2+/calmodulin	Ca2+/calmodulin	ADP	IN	_	_	_	_	SpaceAfter=No
9	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	multifunctional	multifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
14	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	K	k	NUM	CD	NumType=Card	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	calcineurin	calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	type	type	NOUN	NN	Number=Sing	_	_	_	_
34	2B	2b	NOUN	NN	Number=Sing	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5144
# text = Recent studies have identified calcineurin as a key enzyme for interleukin (IL)-2 and IL-4 promoter activation.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
9	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5145
# text = However, the role of CaM-K II remains unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	K	K	PROPN	NNP	Number=Sing	_	_	_	_
9	II	II	PROPN	NNP	Number=Sing	_	_	_	_
10	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5146
# text = We have used mutants of these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively) to explore their relative role in cytokine gene transcription and their interactions with PKC-dependent signaling systems.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
14	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	K	K	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
19	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AI	ai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
27	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
42	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5147
# text = gamma B*CaM-K and delta CaM-AI, known to exhibit constitutive Ca(2+)-independent activity, were cotransfected (alone or in combination) in Jurkat T cells with a plasmid containing the intact IL-2 promoter driving the expression of the chloramphenicol acetyltransferase reporter gene.
1	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
4	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	K	K	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	AI	ai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
16	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	_
17	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
40	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
43	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
47	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
53	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
54	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
55	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5148
# text = Cotransfection of gamma B*CaM-K with the IL-2 promoter construct downregulated its transcription in response to stimulation with ionomycin and phorbol myristate acetate (PMA).
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
6	CaM	CaM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	K	K	NUM	CD	NumType=Card	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
16	downregulated	downregulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
27	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
28	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5149
# text = The inhibitory effect of CaM-K II on IL-2 promoter was associated with decreased transcription of its AP-1 and NF-AT transactivating pathways.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	K	K	NUM	CD	NumType=Card	_	_	_	_
8	II	II	NUM	CD	NumType=Card	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	AT	at	SCONJ	IN	_	_	_	_	_
28	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5150
# text = Under the same conditions, delta CaM-AI superinduced IL-2 promoter activity (approximately twofold increase).
1	Under	under	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
7	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AI	be	PROPN	NNP	Number=Sing	_	_	_	_
10	superinduced	superinduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	twofold	twofold	ADJ	JJ	Degree=Pos	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5151
# text = When both mutants were used in combination, gamma B*CaM-K inhibited the induction of the IL-2 promoter by delta CaM-AI.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
12	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	K	K	NUM	CD	NumType=Card	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
26	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	AI	ai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5152
# text = Similar results were obtained when a construct containing the IL-4 promoter also was used.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5153
# text = gamma B*CaM-K also downregulated the activation of AP-1 in response to transfection with a constitutively active mutant of PKC or stimulation with PMA.
1	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
4	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	K	K	PROPN	NNP	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	downregulated	downregulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	transfection	transfection	VERB	VB	VerbForm=Inf	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	constitutively	constitutively	ADV	RB	_	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5154
# text = These results suggest that CaM-K II may exert negative influences on cytokine gene transcription in human T cells, and provide preliminary evidence for negative cross-talk with the calcineurin- and PKC- dependent signaling systems.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	K	K	NUM	CD	NumType=Card	_	_	_	_
8	II	II	NUM	CD	NumType=Card	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	influences	influence	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
24	preliminary	preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
25	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	_
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
38	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5155
# text = Document 003001386 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001386	003001386	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5156
# text = HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.
1	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CD3/CD28	CD3/CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5157
# text = In this report, we demonstrate that the T cell tropic strain of HIV, LAI, does not replicate in naive CD4 T cells stimulated by cross-linking CD3 and CD28.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	tropic	tropic	ADJ	JJ	Degree=Pos	_	_	_	_
12	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	SCONJ	IN	_	_	_	_	_
28	cross-linking	cross-link	VERB	VBG	VerbForm=Ger	_	_	_	_
29	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5158
# text = In contrast, LAI replicates well in memory CD4 T cells stimulated in the same way.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LAI	LAI	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	replicates	replicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	way	way	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5159
# text = Unlike this physiologically relevant stimulation, PHA stimulates productive LAI replication in both naive and memory T cells.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	physiologically	physiologically	ADV	RB	_	_	_	_	_
4	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
10	LAI	Lai	NOUN	NN	Number=Sing	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	memory	memory	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5160
# text = These studies were conducted with highly purified (FACS-isolated) subsets of CD4 T cells identified by expression of both CD45RA and CD62L.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	FACS	Fac	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	CD45RA	CD45RA	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	CD62L	CD62L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5161
# text = Remixing of purified T cells showed that naive T cells do not suppress LAI replication in memory T cells and that memory T cells do not restore LAI expression in naive T cells.
1	Remixing	Remixing	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
14	LAI	Lai	ADJ	JJ	Degree=Pos	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
28	LAI	Lai	PROPN	NNP	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5162
# text = The suppression of productive LAI replication in naive T cells is not due to differential expression of viral coreceptors, nor is it due to inhibition of activation of the important HIV transcription factors, nuclear factor-kappaB and activator protein-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
5	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	due	due	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	coreceptors	coreceptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	nor	nor	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	due	due	ADP	IN	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5163
# text = The inherent resistance of naive T cells to productive HIV infection, coupled with their proliferative advantage as demonstrated here, provides a sound basis for proposed clinical therapies using ex vivo expansion and reinfusion of CD4 T cells from HIV-infected adults.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inherent	inherent	ADJ	JJ	Degree=Pos	_	_	_	_
3	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	productive	productive	VERB	VB	VerbForm=Inf	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
17	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	sound	sound	NOUN	NN	Number=Sing	_	_	_	_
25	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
29	therapies	therapy	NOUN	NNS	Number=Plur	_	_	_	_
30	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
31	ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
33	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	reinfusion	reinfusion	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5164
# text = Document 003001387 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001387	003001387	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5165
# text = Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5166
# text = Critical role for IL-6.
1	Critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5167
# text = The T cell activation is initiated by interaction of specific Ags with TCR, followed by activation of intracellular biochemical events leading to activation of several genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ags	ag	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	TCR	Tcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
21	events	event	NOUN	NNS	Number=Plur	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5168
# text = The activation of signal transducer and activator of transcription (STAT) proteins in a primary TCR-mediated activation of T cells have been explored.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5169
# text = In purified human peripheral blood T cells, nuclear
1	In	in	ADP	IN	_	_	_	_	_
2	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 5170
# text = STAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	approximately	approximately	ADV	RB	_	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	h	h	NOUN	NN	Number=Sing	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-CD3	anti-CD3	X	ADD	_	_	_	_	_

# sent_id = 5171
# text = Abs.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5172
# text = These STAT proteins were detected by using the IFN-gamma-activated sequence (GAS) and related oligonucleotides as probes in electrophoretic mobility shift assay.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5173
# text = Analysis of the nuclear extracts with anti-STAT Abs indicated that they contained STAT-3 and additional proteins crossreactive with the STAT family.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	anti-STAT	anti-stat	ADJ	JJ	Degree=Pos	_	_	_	_
8	Abs	Abs	NOUN	NNS	Number=Plur	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	crossreactive	crossreactive	ADJ	JJ	Degree=Pos	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5174
# text = The induction of STAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A, thus indicating that the induction was due to a secondary factor produced by the activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
16	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	thus	thus	ADV	RB	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	due	due	ADP	IN	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5175
# text = As neutralizing anti-IL-6
1	As	as	SCONJ	IN	_	_	_	_	_
2	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
3	anti-IL	anti-IL	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5176
# text = Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR-mediated bindings, it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response.
1	Abs	Ab	ADV	RB	_	_	_	_	_
2	effectively	effectively	ADV	RB	_	_	_	_	_
3	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	exogenously	exogenously	ADV	RB	_	_	_	_	_
15	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	rapidly	rapidly	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	bindings	bindings	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	6	6	NUM	CD	NumType=Card	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
47	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5177
# text = Document 003001388 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001388	003001388	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5178
# text = Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: identification of a GATA-2 binding element required for optimal transcriptional activity.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5179
# text = Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the Ig gene superfamily that is expressed on platelets, endothelial cells, and certain leukocyte subsets.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	130	130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
19	member	member	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
36	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
37	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5180
# text = To examine the factors controlling vascular-specific expression of PECAM-1, we cloned the 5'-flanking region of the PECAM-1 gene and analyzed its transcriptional activity.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
6	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5181
# text = 5'-Rapid amplification of cDNA ends (5'-RACE) analysis showed that transcription initiation occurred at several closely spaced nearby sites originating approximately 204 bp upstream from the translation start site.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	Rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	amplification	amplification	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
8	ends	end	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
12	RACE	race	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	analysis	analysis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	closely	closely	ADV	RB	_	_	_	_	_
23	spaced	space	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	nearby	nearby	ADJ	JJ	Degree=Pos	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	originating	originat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	approximately	approximately	ADV	RB	_	_	_	_	_
28	204	204	NUM	CD	NumType=Card	_	_	_	_
29	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
30	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
34	start	start	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5182
# text = Analysis of the sequence immediately upstream from the transcription initiation site (TIS) showed no canonical TATA or CAAT elements, however an initiator element commonly found in TATA-less promoters encompassed the TIS.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	immediately	immediately	ADV	RB	_	_	_	_	_
6	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TIS	TIS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
18	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	however	however	ADV	RB	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	initiator	initiator	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	commonly	commonly	ADV	RB	_	_	_	_	_
28	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	TATA	TATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
33	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
34	encompassed	encompass	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	TIS	tis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5183
# text = 5'-serially truncated PECAM-1 promoter segments cloned in front of a luciferase reporter drove transcription in both a lineage- and orientation-specific manner.
1	5	5	X	LS	_	_	_	_	SpaceAfter=No
2	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
3	serially	serially	ADV	RB	_	_	_	_	_
4	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
10	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	front	front	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	drove	drive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5184
# text = Putative cis-acting control elements present within a 300-bp core promoter included two ets sites, an Sp1 site, tandem E-box domains, two GATA-associated sites (CACCC), an AP-2 binding site, and a GATA element at -24.
1	Putative	Putative	ADJ	JJ	Degree=Pos	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
4	control	control	NOUN	NN	Number=Sing	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	core	core	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
24	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	box	box	NOUN	NN	Number=Sing	_	_	_	_
26	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
47	element	element	NOUN	NN	Number=Sing	_	_	_	_
48	at	at	ADP	IN	_	_	_	_	_
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5185
# text = Mutational analysis showed that optimal transcriptional activity required the GATA sequence at position -24, and gel-shift assays further showed that the GATA-2 transcription factor, but not GATA-1, bound to this region of the PECAM-1 promoter.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
22	further	further	ADV	RB	_	_	_	_	_
23	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	ADV	RB	_	_	_	_	_
34	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	region	region	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5186
# text = Understanding the cis- and transacting factors that regulate the tissue-specific expression of PECAM-1 should increase our understanding of the mechanisms by which vascular-specific gene expression is achieved.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transacting	transact	VERB	VBG	VerbForm=Ger	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
20	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
21	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
22	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5187
# text = Document 003001389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001389	003001389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5188
# text = Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
1	Ectopic	Ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
6	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
13	arrests	arrest	NOUN	NNS	Number=Plur	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5189
# text = The GATA factors are a family of transcriptional regulatory proteins in eukaryotes that share extensive homology in their DNA-binding domains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	eukaryotes	eukaryote	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
16	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5190
# text = One enigmatic aspect of GATA factor expression is that several GATA proteins, which ostensibly share the same DNA-binding site specificity, are coexpressed in erythroid cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	enigmatic	enigmatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	aspect	aspect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	ostensibly	ostensibly	ADV	RB	_	_	_	_	_
16	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5191
# text = To elucidate the roles of individual GATA factors in erythropoiesis, conditional alleles of GATA-1, GATA-2, and GATA-3 were prepared by fusing each of the factors to the hormone-binding domain of the human estrogen receptor (ER).
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	erythropoiesis	erythropoiesis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
13	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	fusing	fuse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	each	each	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
44	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
45	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5192
# text = These GATA/ER chimeric factors were shown to be hormone-inducible trans-activating proteins in transient transfection assays.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
4	ER	er	NOUN	NN	Number=Sing	_	_	_	_
5	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	hormone	hormone	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
20	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5193
# text = When stably introduced into primary erythroblasts or conditionally transformed erythroid progenitors cells, exogenous GATA-2/ER promoted proliferation and inhibited terminal differentiation in an estrogen-dependent manner.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	stably	stably	ADV	RB	Degree=Pos	_	_	_	_
3	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	into	into	ADP	IN	_	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	conditionally	conditionally	ADV	RB	_	_	_	_	_
9	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	exogenous	exogenous	CCONJ	CC	_	_	_	_	_
15	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2/ER	2/er	PROPN	NNP	Number=Sing	_	_	_	_
18	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5194
# text = These phenotypic effects are specifically attributable to the action of ectopically expressed GATA-2/ER because erythroblasts expressing exogenous GATA-2 are constitutively arrested in differentiation and because erythroid progenitors expressing either Gal/ER or GATA-3/ER do not display a hormone-responsive block in differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	ectopically	ectopically	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2/ER	2/er	PROPN	NNP	Number=Sing	_	_	_	_
16	because	because	SCONJ	IN	_	_	_	_	_
17	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
18	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	arrested	arrest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	because	because	SCONJ	IN	_	_	_	_	_
30	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
31	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
32	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	either	either	DET	DT	_	_	_	_	_
34	Gal/	Gal/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	ER	er	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-3/ER	-3/er	PROPN	NNP	Number=Sing	_	_	_	_
39	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	not	not	PART	RB	_	_	_	_	_
41	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
46	block	block	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5195
# text = Thus, the GATA-2 transcription factor appears to play a role in regulating the self-renewal capacity of early erythroid progenitor cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	renewal	renewal	ADJ	JJ	Degree=Pos	_	_	_	_
20	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
23	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
24	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5196
# text = Document 003001390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001390	003001390	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5197
# text = Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription.
1	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
6	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
25	ligand	ligand	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5198
# text = Bcl-2 inhibits apoptosis induced by a variety of stimuli, including chemotherapy drugs and glucocorticoids.
1	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	_
15	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5199
# text = It is generally accepted that Bcl-2 exerts its antiapoptotic effects mainly by dimerizing with proapoptotic members of the Bcl-2 family such as Bax and Bad.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	generally	generally	ADV	RB	_	_	_	_	_
4	accepted	accept	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	mainly	mainly	ADV	RB	_	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	dimerizing	dimerize	VERB	VBG	VerbForm=Ger	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	Bax	Bax	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Bad	Bad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5200
# text = However, the mechanism of the antiapoptotic effects is unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5201
# text = Paclitaxel and other drugs that disturb microtubule dynamics kill cells in a Fas/Fas ligand (FasL)-dependent manner; antibody to FasL inhibits paclitaxel-induced apoptosis.
1	Paclitaxel	Paclitaxel	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	disturb	disturb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
8	dynamics	dynamics	NOUN	NNS	Number=Plur	_	_	_	_
9	kill	kill	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
16	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FasL	FasL	INTJ	UH	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
27	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
28	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5202
# text = We have found that Bcl-2 overexpression leads to the prevention of chemotherapy (paclitaxel)-induced expression of FasL and blocks paclitaxel-induced apoptosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
9	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
25	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5203
# text = The mechanism of this effect is that Bcl-2 prevents the nuclear translocation of NFAT (nuclear factor of activated T lymphocytes, a transcription factor activated by microtubule damage) by binding and sequestering calcineurin, a calcium-dependent phosphatase that must dephosphorylate NFAT to move to the nucleus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
31	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	by	by	SCONJ	IN	_	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	sequestering	sequester	VERB	VBG	VerbForm=Ger	_	_	_	_
37	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
43	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
46	dephosphorylate	dephosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
47	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
48	to	to	PART	TO	_	_	_	_	_
49	move	move	VERB	VB	VerbForm=Inf	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5204
# text = Without NFAT nuclear translocation, the FasL gene is not transcribed.
1	Without	without	ADP	IN	_	_	_	_	_
2	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5205
# text = Thus, it appears that paclitaxel and other drugs that disturb microtubule function kill cells at least in part through the induction of FasL.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	disturb	disturb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	kill	kill	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADV	RB	_	_	_	_	_
17	least	least	ADV	RBS	Degree=Sup	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	part	part	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	FasL	FasL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5206
# text = Furthermore, Bcl-2 antagonizes drug-induced apoptosis by inhibiting calcineurin activation, blocking NFAT nuclear translocation, and preventing FasL expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	antagonizes	antagonize	NOUN	NNS	Number=Plur	_	_	_	_
7	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
13	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
17	NFAT	Nfat	PRON	WP	PronType=Int	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
23	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5207
# text = The effects of Bcl-2 can be overcome, at least partially, through phosphorylation of Bcl-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	overcome	overcome	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	at	at	ADV	RB	_	_	_	_	_
12	least	least	ADV	RBS	Degree=Sup	_	_	_	_
13	partially	partially	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5208
# text = Phosphorylated Bcl-2 cannot bind calcineurin, and NFAT activation, FasL expression, and apoptosis can occur after Bcl-2 phosphorylation.
1	Phosphorylated	Phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
6	not	not	PART	RB	_	_	_	_	_
7	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
8	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5209
# text = Document 003001391 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001391	003001391	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5210
# text = NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
12	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5211
# text = During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis before being cleared by phagocytes in a non-phlogistic manner.
1	During	during	ADP	IN	_	_	_	_	_
2	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
3	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	potentially	potentially	ADV	RB	_	_	_	_	_
6	tissue	tissue	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
7	-damaging	-damage	VERB	VBG	VerbForm=Ger	_	_	_	_
8	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	before	before	SCONJ	IN	_	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	cleared	cleare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	non-phlogistic	non-phlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
19	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5212
# text = Here we show that the rate of constitutive apoptosis in human neutrophils and eosinophils is greatly accelerated in both a rapid and concentration-dependent manner by the fungal metabolite gliotoxin, but not by its inactive analog methylthiogliotoxin.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	greatly	greatly	ADV	RB	_	_	_	_	_
17	accelerated	accelerate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	rapid	rapid	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	fungal	fungal	ADJ	JJ	Degree=Pos	_	_	_	_
30	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
31	gliotoxin	gliotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
37	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
38	analog	analog	NOUN	NN	Number=Sing	_	_	_	_
39	methylthiogliotoxin	methylthiogliotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5213
# text = This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	zVAD	zvad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
33	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
38	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
39	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	SN	SN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	;	;	PUNCT	,	_	_	_	_	_
49	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
50	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
53	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	curcumin	curcumin	NOUN	NNS	Number=Plur	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
58	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	;	;	PUNCT	,	_	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
63	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	MG	MG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	132	132	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5214
# text = Gliotoxin also augmented dramatically the early (2-6
1	Gliotoxin	Gliotoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	dramatically	dramatically	ADV	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5215
# text = h) pro-apoptotic effects of tumor necrosis factor-alpha (TNF-alpha) in neutrophils and unmasked the ability of TNF-alpha to induce eosinophil apoptosis.
1	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	pro-apoptotic	pro-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	unmasked	unmask	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	eosinophil	eosinophil	ADP	IN	_	_	_	_	_
29	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5216
# text = In neutrophils, TNF-alpha caused a gliotoxin-inhibitable activation of an inducible form of NF-kappaB, a response that may underlie the ability of TNF-alpha to delay apoptosis at later times (12-24 h) and limit its early killing effect.
1	In	in	ADP	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
7	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	gliotoxin	gliotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	delay	delay	VERB	VB	VerbForm=Inf	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
38	times	time	NOUN	NNS	Number=Plur	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	24	24	NUM	CD	NumType=Card	_	_	_	_
43	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
47	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
48	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	early	early	ADV	RB	Degree=Pos	_	_	_	_
50	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	_
51	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5217
# text = Furthermore, cycloheximide displayed a similar capacity to enhance TNF-alpha induced neutrophil apoptosis even at time points when cycloheximide alone had no pro-apoptotic effect, suggesting that NF-kappaB may regulate the production of protein(s) which protect neutrophils from the cytotoxic effects of TNF-alpha.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
4	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
15	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	even	even	ADV	RB	_	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	time	time	NOUN	NN	Number=Sing	_	_	_	_
19	points	point	NOUN	NNS	Number=Plur	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	cycloheximide	cycloheximide	ADJ	JJ	Degree=Pos	_	_	_	_
22	alone	alone	ADV	RB	_	_	_	_	_
23	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	pro-apoptotic	pro-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	s	s	X	AFX	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
44	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
45	from	from	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
48	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5218
# text = These data shed light on the biochemical and molecular mechanisms regulating human granulocyte apoptosis and, in particular, indicate that the transcription factor NF-kappaB plays a crucial role in regulating the physiological cell death pathway in granulocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	shed	sh	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	light	light	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	indicate	indicate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	SCONJ	IN	_	_	_	_	_
33	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	death	death	NOUN	NN	Number=Sing	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5219
# text = Document 003001392 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001392	003001392	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5220
# text = Downstream activation of a TATA-less promoter by Oct-2, Bob1, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells.
1	Downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	less	less	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Bob1	bob1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	homing	home	VERB	VBG	VerbForm=Ger	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	BLR1	BLR1	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5221
# text = The chemokine receptor, BLR1, is a major regulator of the microenvironmental homing of B cells in lymphoid organs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	BLR1	BLR1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	microenvironmental	microenvironmental	ADJ	JJ	Degree=Pos	_	_	_	_
14	homing	homing	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5222
# text = In vitro studies identify three essential elements of the TATA-less blr1 core promoter that confer cell type- and differentiation-specific expression in the B cells of both humans and mice, a functional promoter region (-36 with respect to the transcription start site), a NF-kappaB motif (+44), and a noncanonical octamer motif (+157).
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	three	three	NUM	CD	NumType=Card	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
13	blr1	blr1	NUM	CD	NumType=Card	_	_	_	_
14	core	core	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	confer	confer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	humans	humans	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	36	36	NUM	CD	NumType=Card	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
48	start	start	NOUN	NN	Number=Sing	_	_	_	_
49	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
56	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	+44	+44	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
63	noncanonical	noncanonical	ADJ	JJ	Degree=Pos	_	_	_	_
64	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
65	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	+157	+157	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5223
# text = The importance of these sites was confirmed by in vivo studies in gene-targeted mice deficient of either Oct-2, Bob1, or both NF-kappaB subunits p50 and p52.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
17	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	either	either	CCONJ	CC	_	_	_	_	_
20	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Bob1	bob1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
31	p50	p50	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5224
# text = In all of these animals, the expression of BLR1 was reduced or absent.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	BLR1	BLR1	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5225
# text = In mice deficient only of p52/NF-kappaB, BLR1 expression was unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	mice	mice	NOUN	NN	Number=Sing	_	_	_	_
3	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p52/	p52ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	BLR1	BLR1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5226
# text = Thus our data demonstrate that BLR1 is a target gene for Oct-2, Bob1, and members of the NF-kappaB/Rel family and provides a link to the impaired B cell functions in mice deficient for these factors.
1	Thus	thus	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	BLR1	BLR1	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	target	target	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Bob1	bob1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	link	link	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
39	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5227
# text = Document 003001393 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001393	003001393	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5228
# text = Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.
1	Defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	anergic	anergic	PROPN	NNP	Number=Sing	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5229
# text = Anergic CD4+
1	Anergic	Anergic	PROPN	NNP	Number=Sing	_	_	_	_
2	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 5230
# text = Th cells do not produce IL-2 when challenged with Ag-pulsed accessory cells because of a transcriptional defect.
1	Th	th	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	challenged	challenge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Ag-	Ag-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	pulsed	pulse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	because	because	ADP	IN	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5231
# text = In this work, we report that these anergic T cells are defective in their ability to up-regulate protein binding and transactivation at two critical IL-2 DNA enhancer elements: NF-AT (nuclear factor of activated T cells; a sequence that binds a heterotrimeric NFATp, Fos, and Jun protein complex) and Activator Protein-1 (AP-1) (that binds Fos and Jun heterodimers).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	:	:	PUNCT	:	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	;	;	PUNCT	,	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
48	that	that	PRON	WDT	PronType=Rel	_	_	_	_
49	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	heterotrimeric	heterotrimeric	ADJ	JJ	Degree=Pos	_	_	_	_
52	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
58	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
59	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	Activator	Activator	PROPN	NNP	Number=Sing	_	_	_	_
63	Protein	protein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	1	1	NUM	CD	NumType=Card	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	_
71	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
72	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
73	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
74	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
77	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
78	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5232
# text = Western blot analysis of nuclear extracts showed that the impaired DNA-protein interactions in anergic T cells were associated with poor expression of the inducible AP-1 family members c-Fos, FosB, and JunB.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	poor	poor	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5233
# text = However, the reduced expression of these proteins was not the result of a global TCR/CD3-signaling defect because CD3 cross-linking induced an equivalent increase in intracellular-free calcium ions, as well as NFATp dephosphorylation, translocation to the nucleus, and DNA binding in both normal and anergic T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	result	result	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	global	global	ADJ	JJ	Degree=Pos	_	_	_	_
16	TCR/CD3	TCR/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-signaling	-signal	NOUN	NN	Number=Sing	_	_	_	_
18	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
21	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
31	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
32	ions	ion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	well	well	ADV	RB	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
38	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
47	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	both	both	CCONJ	CC	_	_	_	_	_
50	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
53	T	t	PROPN	NNP	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5234
# text = Thus, defective IL-2 gene transcription appears to be due, at least in part, to a selective block in the expression of the AP-1 Fos and Jun family members in anergic T cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	due	due	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	at	at	ADV	RB	_	_	_	_	_
15	least	least	ADV	RBS	Degree=Sup	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
22	block	block	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	_
35	members	member	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5235
# text = Document 003001394 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001394	003001394	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5236
# text = Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
10	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5237
# text = Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5238
# text = Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals.
1	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	since	since	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	transforms	transform	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5239
# text = We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	_
26	CTLL	Ctll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5240
# text = Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent.
1	Stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	SCONJ	IN	_	_	_	_	_
13	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5241
# text = Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
11	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5242
# text = The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	segregating	segregat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	while	while	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	unnecessary	unnecessary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5243
# text = However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	another	another	DET	DT	_	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	soft	soft	ADJ	JJ	Degree=Pos	_	_	_	_
18	agar	agar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5244
# text = Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
20	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 5245
# text = T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5246
# text = Document 003001395 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001395	003001395	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5247
# text = Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
3	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	receptors	receptor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	inhibit	inhibit	ADJ	JJ	Degree=Pos	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	U1	U1	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5248
# text = Recombinant human tumor necrosis factor (TNF) binding protein-1 (r-h TBP-1) and recombinant human soluble dimeric TNF receptor (rhu TNFR:Fc) were used to determine the relative contributions of TNF to phorbol myristate acetate (PMA) and cytokine-induced human immunodeficiency virus type 1 (HIV-1) replication in chronically infected cell lines.
1	Recombinant	Recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	r	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
25	dimeric	dimeric	ADJ	JJ	Degree=Pos	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	rhu	rhu	NOUN	NN	Number=Sing	_	_	_	_
30	TNFR:	TNFR:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
39	contributions	contribution	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
44	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
45	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
54	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
55	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
56	type	type	NOUN	NN	Number=Sing	_	_	_	_
57	1	1	NUM	CD	NumType=Card	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	chronically	chronically	ADV	RB	_	_	_	_	_
66	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
67	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
68	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5249
# text = Treatment of HIV-1-infected promonocytic U1 cells with r-h-TBP-1 or rhu TNFR:Fc reduced PMA-induced HIV-1 p24 antigen production in a concentration-dependent manner, with a maximal inhibition of approximately 90%.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	U1	u1	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	r-h	r-h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	rhu	rhu	PROPN	NNP	Number=Sing	_	_	_	_
19	TNFR:Fc	TNFR:Fc	PROPN	NNP	Number=Sing	_	_	_	_
20	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	p24	p24	NUM	CD	NumType=Card	_	_	_	_
28	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
40	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	approximately	approximately	ADV	RB	_	_	_	_	_
43	90%	90%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5250
# text = Maximal inhibition of p24 antigen production in T-lymphocytic ACH-2 cells was 47% with r-hTBP-1 and 42% with rhu TNFR:Fc.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p24	p24	NUM	CD	NumType=Card	_	_	_	_
5	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	r-hTBP	r-hTBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	rhu	rhu	NOUN	NN	Number=Sing	_	_	_	_
26	TNFR:	TNFR:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	Fc.	Fc.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5251
# text = r-hTBP-1 and rhu TNFR:Fc also decreased p24 antigen synthesized by U1 cells in response to other stimuli, including phytohemagglutinin (PHA)-induced supernatant, granulocyte-macrophage colony-stimulating factor, interleukin-6, and TNF.
1	r-hTBP	r-hTBp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	rhu	rhu	NOUN	NN	Number=Sing	_	_	_	_
6	TNFR	Tnfr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
8	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	p24	p24	NUM	CD	NumType=Card	_	_	_	_
12	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
13	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	U1	U1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5252
# text = Addition of r-hTBP-1 to U1 cells during the last 4 h of a 24 h incubation with PMA still inhibited p24 antigen production by 15%. U1 cells stimulated with 10(-7) M PMA released approximately 1 ng/ml endogenous TBP-1 with an initial peak observed at 1 h and a second peak at 24 h after PMA stimulation.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	r-hTBP	r-hTBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	U1	U1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	last	last	ADJ	JJ	Degree=Pos	_	_	_	_
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	_
17	h	h	NOUN	NN	Number=Sing	_	_	_	_
18	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
21	still	still	ADV	RB	_	_	_	_	_
22	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	p24	p24	NUM	CD	NumType=Card	_	_	_	_
24	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	15%	15%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_
29	U1	U1	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
35	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	M	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
39	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	approximately	approximately	ADV	RB	_	_	_	_	_
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	ml	ml	ADJ	JJ	Degree=Pos	_	_	_	_
45	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
46	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
52	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
53	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	at	at	ADP	IN	_	_	_	_	_
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	h	h	NOUN	NN	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
60	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
61	at	at	ADP	IN	_	_	_	_	_
62	24	24	NUM	CD	NumType=Card	_	_	_	_
63	h	h	NOUN	NN	Number=Sing	_	_	_	_
64	after	after	ADP	IN	_	_	_	_	_
65	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
66	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5253
# text = r-hTBP-1 also partially reversed inhibition of U1 cellular proliferation caused by PMA.
1	r-hTBP	r-hTBp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	U1	U1	NUM	CD	NumType=Card	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5254
# text = Both r-hTBP-1 and rhu TNFR:Fc blocked PMA induction of nuclear factor (NK)- kappa B DNA-binding activity in U1 cells in association with decreases in HIV-1 replication.
1	Both	both	DET	DT	_	_	_	_	_
2	r-hTBP	r-htbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	rhu	rhu	PROPN	NNP	Number=Sing	_	_	_	_
7	TNFR:Fc	TNFR:Fc	PROPN	NNP	Number=Sing	_	_	_	_
8	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	U1	U1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	association	association	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5255
# text = We conclude that soluble TNF receptors can inhibit stimuli-induced HIV-1 expression and NK- kappa B DNA-binding activity in chronically infected U1 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
5	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
9	stimuli-induced	stimuli-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U1	U1	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5256
# text = Document 003001396 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001396	003001396	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5257
# text = Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	hyporesponsiveness	hyporesponsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
10	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
11	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	lipopolysaccharide/interferon-gamma	lipopolysaccharide/interferon-gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5258
# text = The work reported here resolves, at the level of gene regulation, the controversy as to whether or not human monocytes/macrophages can produce nitric oxide (NO) when stimulated with lipopolysaccharide (LPS), with or without co-stimulation by interferon-gamma (IFN-gamma).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	resolves	resolf	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	controversy	controversy	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	to	to	SCONJ	IN	_	_	_	_	_
18	whether	whether	SCONJ	IN	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
27	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
28	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	NO	no	INTJ	UH	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	when	when	ADV	WRB	PronType=Int	_	_	_	_
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	without	without	ADP	IN	_	_	_	_	_
43	co-stimulation	co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5259
# text = Studies included structural comparison of the promoters for human and mouse inducible NO synthase (iNOS) genes, transfection and assay of human and mouse iNOS promoter regions in response to LPS +/- IFN-gamma, and electrophoretic mobility shift assays of kappa B response elements.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
4	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	human	human	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	NO	no	DET	DT	_	_	_	_	_
14	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	human	human	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
27	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
34	+/-	+/-	PUNCT	:	_	_	_	_	_
35	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
41	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
42	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
43	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B	b	NOUN	NN	Number=Sing	_	_	_	_
47	response	response	NOUN	NN	Number=Sing	_	_	_	_
48	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5260
# text = Two explanations for hyporesponsiveness of the human iNOS promoter to LPS +/- IFN-gamma were found: (1) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate LPS/IFN-gamma induced expression of the mouse iNOS gene; and (2) and absence of one or more nuclear factors in human macrophages (e.g., an LPS-inducible nuclear factor-kappa
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	explanations	explanation	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	hyporesponsiveness	hyporesponsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
12	+/-	+/-	PUNCT	:	_	_	_	_	_
13	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	1	1	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
23	inactivating	inactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
25	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	LPS/IFN	Lps/ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
48	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	_
49	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	;	;	PUNCT	,	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	2	2	X	LS	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	one	one	NUM	CD	NumType=Card	_	_	_	_
59	or	or	CCONJ	CC	_	_	_	_	_
60	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
61	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
62	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
65	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
70	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
71	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
72	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
73	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
74	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5261
# text = B/Rel complex), that is (are) required for maximal expression of the gene.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5262
# text = The importance of resolution of this controversy is that future research in this area should be directed toward the understanding of alternative mechanisms that can result in the successful production of NO.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	controversy	controversy	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	future	future	ADJ	JJ	Degree=Pos	_	_	_	_
11	research	research	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	area	area	NOUN	NN	Number=Sing	_	_	_	_
15	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	toward	toward	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	successful	successful	ADJ	JJ	Degree=Pos	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NO	no	DET	DT	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5263
# text = Document 003001397 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001397	003001397	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5264
# text = Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular model.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	during	during	ADP	IN	_	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
15	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5265
# text = The regulation of gene expression during lymphocyte differentiation is a complex process involving interactions between multiple positive and negative transcriptional regulatory elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	process	process	NOUN	NN	Number=Sing	_	_	_	_
13	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
14	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5266
# text = In this article, transcriptional regulation of the archetypal T-cell-specific gene, alpha TCR, is discussed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	article	article	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	archetypal	archetypal	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	alpha	alpha	ADP	IN	_	_	_	_	_
17	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5267
# text = Major recent developments, including the identification of novel families of transcription factors that regulate multiple T-cell genes during thymocyte ontogeny and T-cell activation, are described.
1	Major	major	ADJ	JJ	Degree=Pos	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	developments	development	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	families	family	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
22	ontogeny	ontogeny	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5268
# text = Document 003001398 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001398	003001398	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5269
# text = Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937.
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	42	42	NUM	CD	NumType=Card	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
12	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monoblast	monoblast	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	U-	u-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5270
# text = To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development, a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Kruppel-related zinc finger genes from the human monoblast cell line U-937.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	complexity	complexity	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
7	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
19	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
20	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	degenerate	degenerate	NOUN	NN	Number=Sing	_	_	_	_
28	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
29	probe	probe	ADV	RB	_	_	_	_	_
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
34	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
35	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
36	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
37	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
42	63	63	NUM	CD	NumType=Card	_	_	_	_
43	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
44	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
49	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
50	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
51	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
52	from	from	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
55	monoblast	monoblast	NOUN	NN	Number=Sing	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	line	line	NOUN	NN	Number=Sing	_	_	_	_
58	U-	u-	SYM	SYM	_	_	_	_	SpaceAfter=No
59	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5271
# text = By extensive nucleotide sequence and Northern blot analysis, these cDNA clones were found to originate from approximately 42 different genes (HZF 1-42) of which only 8 have previously been described.
1	By	by	ADP	IN	_	_	_	_	_
2	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
3	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cDNA	cDNa	ADJ	JJ	Degree=Pos	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	originate	originate	VERB	VB	VerbForm=Inf	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	approximately	approximately	ADV	RB	_	_	_	_	_
19	42	42	NUM	CD	NumType=Card	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HZF	Hzf	PROPN	NNP	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	8	8	NUM	CD	NumType=Card	_	_	_	_
32	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
33	previously	previously	ADV	RB	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5272
# text = Northern blot analysis showed that a majority of these genes were expressed at comparable levels in U-937 and HeLa cells.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	937	937	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5273
# text = The large number of individual genes represented among the 63 clones and their apparent non-cell-type-specific expression suggest that the majority of the Kruppel-related zinc finger genes are likely to be expressed in most human tissues.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
3	number	number	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	represented	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	among	among	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	63	63	NUM	CD	NumType=Card	_	_	_	_
11	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
15	non-cell	non-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
28	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
29	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5274
# text = In contrast, some of the genes displayed a restricted expression pattern, indicating that they represent potential regulators of monocyte differentiation or proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	some	some	DET	DT	_	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
19	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5275
# text = Detailed structural analysis of the first 12 cDNAs (HZF 1-10) and a partial characterization of HZF 11-42 revealed that a common feature of human Kruppel-related zinc finger proteins is the presence of tandem arrays of zinc fingers ranging in number from 3 to over 20 that are preferentially located in the carboxy-terminal regions of the proteins.
1	Detailed	detailed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	12	12	NUM	CD	NumType=Card	_	_	_	_
8	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HZF	HZF	PROPN	NNP	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
18	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HZF	HZF	PROPN	NNP	Number=Sing	_	_	_	_
21	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	42	42	NUM	CD	NumType=Card	_	_	_	_
24	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
28	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
34	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
35	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
42	arrays	array	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
45	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
46	ranging	rang	VERB	VBG	VerbForm=Ger	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	number	number	NOUN	NN	Number=Sing	_	_	_	_
49	from	from	ADP	IN	_	_	_	_	_
50	3	3	NUM	CD	NumType=Card	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	over	over	ADP	IN	_	_	_	_	_
53	20	20	NUM	CD	NumType=Card	_	_	_	_
54	that	that	PRON	WDT	PronType=Rel	_	_	_	_
55	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	preferentially	preferentially	ADV	RB	_	_	_	_	_
57	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
63	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5276
# text = In addition, several novel KRAB-containing zinc finger genes and a novel conserved sequence element were identified.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	KRAB	krab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
15	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5277
# text = Document 003001399 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001399	003001399	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5278
# text = Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types.
1	Contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
14	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5279
# text = Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1, lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat (LTR), proviruses containing reconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation.
1	Starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	incompetent	incompetent	NOUN	NN	Number=Sing	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
17	all	all	DET	PDT	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
31	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
32	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
33	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	proviruses	proviruse	NOUN	NNS	Number=Plur	_	_	_	_
39	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
40	reconstructed	reconstruct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	individual	individual	NOUN	NN	Number=Sing	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
50	B	b	PROPN	NNP	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
53	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
54	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	for	for	ADP	IN	_	_	_	_	_
59	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
60	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
61	to	to	PART	TO	_	_	_	_	_
62	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
63	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
64	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
65	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
66	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	cocultivation	cocultivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5280
# text = Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human T-cell types depending on which element(s) was present in the LTR.
1	Virus	virus	ADJ	JJ	Degree=Pos	_	_	_	_
2	stocks	stock	NOUN	NNS	Number=Plur	_	_	_	_
3	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
7	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	continuum	continuum	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
12	capacities	capacitie	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	which	which	DET	WDT	PronType=Int	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	s	s	X	AFX	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5281
# text = For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites), a hierarchy of cellular permissivity to virus replication (peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat) was observed.
1	For	for	ADP	IN	_	_	_	_	_
2	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	LTRs	LTRs	PROPN	NNP	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	and	and	CCONJ	CC	_	_	_	_	_
22	no	no	DET	DT	_	_	_	_	_
23	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	hierarchy	hierarchy	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	permissivity	permissivity	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
35	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
38	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
39	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	=	=	PUNCT	,	_	_	_	_	_
41	MT4	MT4	PROPN	NNP	Number=Sing	_	_	_	_
42	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
43	than	than	ADP	IN	_	_	_	_	_
44	H9	H9	NUM	CD	NumType=Card	_	_	_	_
45	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
46	than	than	ADP	IN	_	_	_	_	_
47	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
48	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
49	than	than	ADP	IN	_	_	_	_	_
50	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
53	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5282
# text = Of note was the associated emergence of second-site LTR revertants which involved an alteration of the TATA box.
1	Of	of	ADP	IN	_	_	_	_	_
2	note	note	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	associated	associated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
12	revertants	revertant	NOUN	NNS	Number=Plur	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	involved	involve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
20	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5283
# text = These results suggest that the human immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different T-cell types and is capable of changing depending on the particular combination of transcriptional factors present.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
12	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	redundancy	redundancy	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	ensures	ensure	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	types	type	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
27	of	of	SCONJ	IN	_	_	_	_	_
28	changing	change	VERB	VBG	VerbForm=Ger	_	_	_	_
29	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
33	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5284
# text = Document 003001400 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001400	003001400	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5285
# text = Oxidant-regulation of gene expression in the chronically inflamed intestine.
1	Oxidant	Oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	chronically	chronically	ADV	RB	_	_	_	_	_
10	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	intestine	intestine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5286
# text = It is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's disease) is associated with enhanced production of leukocyte-derived oxidants.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	becoming	become	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	increasingly	increasingly	ADV	RB	_	_	_	_	_
5	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
9	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
10	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
11	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	idiopathic	idiopathic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	e.g.	e.g.	X	FW	_	_	_	_	_
20	ulcerative	ulcerative	ADJ	JJ	Degree=Pos	_	_	_	_
21	colitis	colitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Crohn	Crohn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5287
# text = Oxidants such as hydrogen peroxide are known to activate certain transcription factors such as nuclear transcription factor kappa beta.
1	Oxidants	Oxidant	NOUN	NNS	Number=Plur	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
5	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5288
# text = Nuclear transcription factor kB (NF-kappa B) is a ubiquitous transcription factor and pleiotropic regulator of numerous genes involved in the immune and inflammatory responses.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5289
# text = This transcription factor is activated via the selective phosphorylation, ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules (e.g. ICAM-1, VCAM-1), cytokines (TNF, IL-1, IL-6) and enzymes (iNOS).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	via	via	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	ubiquination	ubiquination	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
21	thereby	thereby	ADV	RB	_	_	_	_	_
22	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
32	where	where	ADV	WRB	PronType=Rel	_	_	_	_
33	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	upregulates	upregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
42	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	e.g.	e.g.	X	FW	_	_	_	_	_
45	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	VCAM	VCAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
63	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
64	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
68	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
69	iNOS	ino	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5290
# text = The proteolytic degradation of the post-translationally modified I-kappa B is known to be mediated by the 26S proteasome complex.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	post	post	X	AFX	_	_	_	_	SpaceAfter=No
7	-translationally	-translationally	ADV	RB	_	_	_	_	_
8	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	S	s	NOUN	NN	Number=Sing	_	_	_	_
22	proteasome	proteasome	DET	DT	_	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5291
# text = Based upon work from our laboratory, we propose that inhibition of NF-kappa B activation produces significant anti inflammatory activity which may be mediated by the inhibition of transcription of certain pro-inflammatory mediators and adhesion molecules.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upon	upon	ADP	IN	_	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	produces	produce	NOUN	NNS	Number=Plur	_	_	_	_
19	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
20	anti	anti	X	AFX	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
34	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
38	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5292
# text = Document 003001401 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001401	003001401	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5293
# text = Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
16	linkage	linkage	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
25	5q23	5q23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	31	31	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5294
# text = Interleukin-13 (IL-13) and IL-4 are cytokines produced by T cells that are encoded by the q23-31 region of human chromosome 5.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-13	-13	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
14	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	q23	q23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-31	-31	NUM	CD	NumType=Card	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5295
# text = To investigate the regulation of IL-13 gene expression by T cells, we isolated and sequenced the human IL-13 gene, analyzed its 5'-flanking region for potential transcriptional activation elements, and examined its expression in nontransformed T-lineage cell populations.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	13	13	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	sequenced	sequence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	13	13	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	nontransformed	nontransform	ADJ	JJ	Degree=Pos	_	_	_	_
46	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5296
# text = The human IL-13 gene was located 12.5-kb upstream of the IL-4 gene and 2-kb downstream of a CpG island.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	13	13	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	12.5	12.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
12	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
23	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
27	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5297
# text = The IL-13 gene 5' flank region included a segment with sequence homology to P elements of the IL-4 promoter involved in transcriptional activation in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	13	13	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	_
8	flank	flank	NOUN	NN	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5298
# text = Mutation of the IL-13
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-13	-13	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5299
# text = P element site significantly reduced IL-13 promoter activity in response to T-cell activation.
1	P	p	SYM	NFP	_	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	13	13	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5300
# text = Oligonucleotides containing the IL-13 or IL-4 P element sites specifically bound the transcriptional activator protein, nuclear factor-activated T cells, preformed (NF-ATp), when incubated with nuclear protein extracts from activated T cells.
1	Oligonucleotides	Oligonucleotides	SCONJ	IN	_	_	_	_	_
2	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	P	p	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	specifically	specifically	ADV	RB	_	_	_	_	_
15	bound	bound	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-activated	-activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	preformed	preform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	when	when	ADV	WRB	PronType=Int	_	_	_	_
35	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
39	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5301
# text = Similar to IL-4, IL-13 mRNA expression was highest in T-cell populations enriched for cells that had previously been primed in vivo or in vitro, indicating that priming increases the expression of the IL-13 and IL-4 genes in a coordinate manner.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
18	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	previously	previously	ADV	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
35	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	13	13	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	4	4	NUM	CD	NumType=Card	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
51	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5302
# text = Because the primed T cells contain higher levels of nuclear NF-ATp, capable of binding to P elements of the IL-4 and IL-13 promoters, than do freshly-isolated T cells, the NF-AT-binding P elements are attractive candidates to mediate the coordinate expression of these two cytokine genes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	P	p	PROPN	NNP	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	13	13	NUM	CD	NumType=Card	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	than	than	SCONJ	IN	_	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	freshly	freshly	ADV	RB	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
46	P	p	NOUN	NN	Number=Sing	_	_	_	_
47	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
48	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
49	attractive	attractive	ADJ	JJ	Degree=Pos	_	_	_	_
50	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
51	to	to	PART	TO	_	_	_	_	_
52	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
55	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
58	two	two	NUM	CD	NumType=Card	_	_	_	_
59	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
60	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5303
# text = Document 003001402 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001402	003001402	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5304
# text = Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B [published erratum appears in Science 1991 Oct 4;254(5028):11]
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rel-	rel-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	potentially	potentially	ADV	RB	_	_	_	_	_
10	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kD	k	NOUN	NN	Number=Sing	_	_	_	_
15	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
24	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	Science	Science	PROPN	NNP	Number=Sing	_	_	_	_
27	1991	1991	NUM	CD	NumType=Card	_	_	_	_
28	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
29	4;254	4;254	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	5028	5028	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	:11	:11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5305
# text = A DNA probe that spanned a domain conserved among the proto-oncogene c-rel, the Drosophila morphogen dorsal, and the p50 DNA binding subunit of NF-kappa B was generated from Jurkat T cell complementary DNA with the polymerase chain reaction (PCR) and degenerate oligonucleotides.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	spanned	span	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	among	among	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
13	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
18	morphogen	morphogen	NOUN	NN	Number=Sing	_	_	_	_
19	dorsal	dorsal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
36	T	T	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
38	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
43	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
44	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	degenerate	degenerate	ADJ	JJ	Degree=Pos	_	_	_	_
50	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5306
# text = This probe was used to identify a rel-related complementary DNA that hybridized to a 2.6-kilobase messenger RNA present in human T and B lymphocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rel-related	rel-relate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	hybridized	hybridize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	2.6	2.6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
18	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
19	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
20	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5307
# text = In vitro transcription and translation of the complementary DNA resulted in the synthesis of a protein with an apparent molecular size of 65 kilodaltons (kD).
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
20	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
21	size	size	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	65	65	NUM	CD	NumType=Card	_	_	_	_
24	kilodaltons	kilodalton	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5308
# text = The translated protein showed weak DNA binding with a specificity for the kappa B binding motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5309
# text = This protein-DNA complex comigrated with the complex obtained with the purified human p65 NF-kappa
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	comigrated	comigrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5310
# text = B subunit and binding was inhibited by I kappa B-alpha and -beta proteins.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5311
# text = In addition, the 65-kD protein associated with the p50 subunit of NF-kappa B and the kappa B probe to form a complex with the same electrophoretic mobility as the NF-kappa B-DNA complex.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kD	k	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
41	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5312
# text = Therefore the rel-related 65-kD protein may represent the p65 subunit of the active NF-kappa B transcription factor complex.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	rel-related	rel-related	ADJ	JJ	Degree=Pos	_	_	_	_
4	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5313
# text = Document 003001403 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001403	003001403	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5314
# text = Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	12	12	NUM	CD	NumType=Card	_	_	_	_
6	p40	p40	NUM	CD	NumType=Card	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
10	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
11	via	via	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 5315
# text = Interleukin-12 is produced in response to infection with bacteria or parasites or to bacterial constituents such as LPS in monocytes/macrophages and dendritic cells, and also generated by the interaction between activated T cells and antigen-presenting cells via CD40-CD40 ligand (CD40L).
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	parasites	parasite	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
17	constituents	constituent	NOUN	NNS	Number=Plur	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
35	between	between	ADP	IN	_	_	_	_	_
36	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T	T	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	via	via	ADP	IN	_	_	_	_	_
45	CD40-	Cd40-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
47	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	CD40L	CD40L	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5316
# text = So far, transcriptional analyses of p40 have been carried out only using bacterial constituents such as LPS as stimuli.
1	So	so	ADV	RB	_	_	_	_	_
2	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	out	out	ADP	RP	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	constituents	constituent	NOUN	NNS	Number=Plur	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5317
# text = In the present study, we have characterized the transcriptional induction of p40 by CD40 ligation in a human B lymphoblastoid cell line, Daudi, and a human acute monocytic leukemia cell line, THP-1.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p40	p40	NUM	CD	NumType=Card	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
16	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5318
# text = These cells, stimulated by an agonistic monoclonal antibody against CD40 or by transfection with a CD40L expression vector, secreted p40 and showed enhanced p40 mRNA expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	agonistic	agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
10	against	against	ADP	IN	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	p40	p40	NUM	CD	NumType=Card	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5319
# text = Sequence analysis of the p40 promoter region identified two potential nuclear factor (NF)-kappaB binding sites conserved between mouse and human.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p40	p40	NUM	CD	NumType=Card	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5320
# text = Electrophoretic mobility shift assay revealed that the potential NF-kappaB binding sequence which is located around 120 bp upstream of the transcription initiation site in murine and human p40 genes formed an NF-kappaB complex with nuclear extract from Daudi cells stimulated by CD40 ligation.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	around	around	ADP	IN	_	_	_	_	_
18	120	120	NUM	CD	NumType=Card	_	_	_	_
19	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	p40	p40	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
47	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5321
# text = Moreover, transfection of Daudi cells with the polymerized NF-kappaB binding sequence ligated to a thymidine kinase/chloramphenicol acetyltransferase (CAT) reporter plasmid greatly induced CAT activity, but transfection with the polymerized mutated NF-kappaB binding sequence did not.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Daudi	Daudi	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	polymerized	polymerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	ligated	ligate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
22	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
28	greatly	greatly	ADV	RB	_	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	polymerized	polymerize	NOUN	NN	Number=Sing	_	_	_	_
38	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
42	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
43	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
44	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5322
# text = These results suggest that the NF-kappaB binding site located around 120 bp upstream of the transcription initiation site in murine and human p40 promoter regions could be important for the p40 induction by CD40 ligation via activation of NF-kappaB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	around	around	ADV	RB	_	_	_	_	_
13	120	120	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
37	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
38	via	via	ADP	IN	_	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5323
# text = Document 003001404 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001404	003001404	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5324
# text = Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB.
1	Inactivation	Inactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5325
# text = In resting T lymphocytes, the transcription factor NF-kappaB is sequestered in the cytoplasm via interactions with members of the I kappa B family of inhibitors, including IkappaBalpha and IkappaBbeta.
1	In	in	SCONJ	IN	_	_	_	_	_
2	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	I	I	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5326
# text = During normal T-cell activation, IkappaBalpha is rapidly phosphorylated, ubiquitinated, and degraded by the 26S proteasome, thus permitting the release of functional NF-kappaB.
1	During	during	ADP	IN	_	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	rapidly	rapidly	ADV	RB	_	_	_	_	_
10	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	ubiquitinated	ubiquitinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	S	be	NOUN	NN	Number=Sing	_	_	_	_
20	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	thus	thus	ADV	RB	_	_	_	_	_
23	permitting	permitt	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	release	release	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5327
# text = In contrast to its transient pattern of nuclear induction during an immune response, NF-kappaB is constitutively activated in cells expressing the Tax transforming protein of human T-cell leukemia virus type I (HTLV-1).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
6	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
33	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5328
# text = Recent studies indicate that HTLV-1 Tax targets IkappaBalpha to the ubiquitin-proteasome pathway.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
10	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ubiquitin-	ubiquitin-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5329
# text = However, it remains unclear how this viral protein induces a persistent rather than transient NF-kappaB response.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	how	how	ADV	WRB	PronType=Int	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	persistent	persistent	NOUN	NN	Number=Sing	_	_	_	_
13	rather	rather	ADV	RB	_	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5330
# text = In this report, we provide evidence that in addition to acting on IkappaBalpha, Tax stimulates the turnover Of IkappaBbeta via a related targeting mechanism.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	SCONJ	IN	_	_	_	_	_
12	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
17	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
20	Of	of	ADP	IN	_	_	_	_	_
21	IkappaBbet	IkappaBbet	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	via	via	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5331
# text = Like IkappaBalpha, Tax-mediated breakdown of IkappaBbeta in transfected T lymphocytes is blocked either by cell-permeable proteasome inhibitors or by mutation Of IkappaBbeta at two serine residues present within its N-terminal region.
1	Like	like	ADP	IN	_	_	_	_	_
2	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	breakdown	breakdown	ADP	IN	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
26	Of	of	ADP	IN	_	_	_	_	_
27	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
31	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
32	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
35	N-	n-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5332
# text = Despite the dual specificity of HTLV-1 Tax for IkappaBalpha and IkappaBbeta at the protein level, Tax selectively stimulates NF-kappaB-directed transcription of the IkappaBalpha gene.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
4	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
20	selectively	selectively	ADV	RB	_	_	_	_	_
21	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5333
# text = Consequently, IkappaBbeta protein expression is chronically downregulated in HTLV-1-infected T lymphocytes.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	chronically	chronically	ADV	RB	_	_	_	_	_
8	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5334
# text = These findings with IkappaBbeta provide a potential mechanism for the constitutive activation of NF-kappaB in Tax-expressing cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
5	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5335
# text = Document 003001405 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001405	003001405	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5336
# text = The role of nuclear factor-kappa B in cytokine gene regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5337
# text = Transcription factors are DNA-binding proteins that regulate gene expression.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5338
# text = Nuclear factor-kappa B (NF-kappa B) is a critical transcription factor for maximal expression of many cytokines that are involved in the pathogenesis of inflammatory diseases, such as adult respiratory distress syndrome (ARDS) and sepsis syndrome.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
36	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
37	distress	distress	NOUN	NN	Number=Sing	_	_	_	_
38	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	sepsis	sepsis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5339
# text = Activation and regulation of NF-kappa B are tightly controlled by a group of inhibitory proteins (I kappa B) that sequester NF-kappa B in the cytoplasm of immune/inflammatory effector cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	tightly	tightly	ADV	RB	_	_	_	_	_
11	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	group	group	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	sequester	sequester	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5340
# text = NF-kappa B activation involves signaled phosphorylation, ubiquitination, and proteolysis of I kappa B.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	ubiquitination	ubiquitination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5341
# text = Liberated NF-kappa B migrates to the nucleus, where it binds to specific promoter sites and activates gene transcription.
1	Liberated	Liberate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	migrates	migrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	where	where	ADV	WRB	PronType=Rel	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5342
# text = The activation of NF-kappa B initiates both extracellular and intracellular regulatory events that result in autoregulation of the inflammatory cascade through modulation of NF-kappa B activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5343
# text = Recently, activation of NF-kappa B has been linked to ARDS and has been shown to be a critical proximal step in the initiation of neutrophilic inflammation in animal models.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
23	step	step	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	neutrophilic	neutrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
29	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
32	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5344
# text = Activation of NF-kappa B can be inhibited in vivo by treatment with antioxidants, corticosteroids, and the induction of endotoxin tolerance.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	corticosteroids	corticosteroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
24	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5345
# text = Identification of more specific and efficacious inhibitors of NF-kappa B activation might prove beneficial for the treatment of cytokine-mediated inflammatory diseases.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	efficacious	efficacious	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
15	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
16	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5346
# text = Document 003001406 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001406	003001406	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5347
# text = OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.
1	OBF	Obf	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	association	association	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5348
# text = Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	components	component	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5349
# text = Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oct-binding factor 1 (OBF-1), a novel protein that specifically associates with Oct-1 and Oct-2.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
4	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	yeast	yeast	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
16	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
17	Oct-	Oct-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	OBF	Obf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	specifically	specifically	ADV	RB	_	_	_	_	_
32	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-1	-1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5350
# text = Biochemical studies demonstrate that OBF-1 has no intrinsic DNA-binding activity and recognizes the POU domains of Oct-1 and Oct-2, but not those of Oct-4 and Oct-6.
1	Biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	OBF	OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	POU	pou	NOUN	NN	Number=Sing	_	_	_	_
19	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5351
# text = The OBF-1 mRNA is expressed in a highly cell-specific manner, being most abundant in B cells and essentially absent in most of the other cells or tissues tested.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	OBF	Obf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	highly	highly	ADV	RB	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	essentially	essentially	ADV	RB	_	_	_	_	_
24	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
33	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5352
# text = Furthermore, expression of OBF-1 in HeLa cells selectively stimulates the activity of a natural immunoglobulin promoter in an octamer site-dependent manner.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	OBF	OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	selectively	selectively	ADV	RB	_	_	_	_	_
12	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
18	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5353
# text = Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	OBF	OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	all	all	DET	PDT	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
10	expected	expect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5354
# text = Document 003001407 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001407	003001407	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5355
# text = T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
11	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	preliminary	preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
24	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5356
# text = Recent data suggest that the poor induction of a T-cell response to human renal cell carcinoma (RCC) may be related to alterations in signal transduction pathways.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	poor	poor	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5357
# text = We report that T cells from RCC patients have two alterations in kappa B motif-specific DNA-binding activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5358
# text = The first alteration involves the constitutive expression of substantial kappa B-binding activity in nuclear extracts, which was observed in the electrophoretic mobility shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
4	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5359
# text = The magnitude of kappa B activity in unstimulated patient T cells was similar to that observed in T cells from normal individuals that had been activated in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
9	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5360
# text = On the basis of Western blotting experiments using antibodies to kappa
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
6	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
7	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5361
# text = B/Rel family proteins, the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 (p50) subunit.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	constitutively	constitutively	ADV	RB	_	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	mostly	mostly	ADV	RB	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5362
# text = The second abnormality in kappa B-binding activity in T cells from these patients is that RelA, a member of the Rel homology family which is part of the normal NF-kappa B complex, was not induced in the nucleus following activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	ADP	IN	Typo=Yes	_	_	_	_
17	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	member	member	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
24	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	part	part	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
44	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5363
# text = Western blotting analysis did not detect any RelA in nuclear extracts either before or after stimulation of T cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
7	any	any	DET	DT	_	_	_	_	_
8	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	before	before	ADV	RB	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5364
# text = The altered kappa B-binding activity in T cells from RCC patients may impair their capacity to respond normally to various stimuli.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	impair	impair	VERB	VB	VerbForm=Inf	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
19	normally	normally	ADV	RB	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5365
# text = Document 003001408 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001408	003001408	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5366
# text = Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
4	E2	E2	NUM	CD	NumType=Card	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	Th0	Th0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5367
# text = The effects of prostaglandin E2 (PGE2) on cytokine production and proliferation of the CD4+ human helper
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
5	E2	E2	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	helper	helper	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5368
# text = T cell clone SP-B21 were investigated.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	B21	b21	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5369
# text = In cells stimulated with anti-CD3 mAb, PGE2 inhibited cell proliferation and the production of all the cytokines examined.
1	In	in	ADP	IN	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	PGE2	PGE2	PART	TO	Abbr=Yes	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	all	all	DET	PDT	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
19	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5370
# text = Addition of rIL-2 fully restored the proliferative response and partially restored the production of IL-4 and IL-5, but not that of other cytokines.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	rIL	rIL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	fully	fully	ADV	RB	_	_	_	_	_
7	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	partially	partially	ADV	RB	_	_	_	_	_
13	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5371
# text = In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
10	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	/A23187	/A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	partially	partially	ADV	RB	_	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	production	production	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5372
# text = Therefore, the effects of PGE2 vary depending on the mode of T cell activation, and the IL-4 and IL-5 are regulated differently from other cytokines.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PGE2	PGE2	NOUN	NN	Number=Sing	_	_	_	_
7	vary	vary	NOUN	NN	Number=Sing	_	_	_	_
8	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	differently	differently	ADV	RB	_	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5373
# text = In a mobility shift assay, only the NF-kappa B (p50/p50) homodimer was observed in a complex formed with the kappa B sequence in unstimulated SP-B21 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
32	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	21	21	NUM	CD	NumType=Card	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5374
# text = When cells were stimulated with anti-CD3 mAb or PMA/A23187, a complex formation of NF-kappa B (p50/p65) heterodimer with the kappa B sequence was induced.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	A23187	A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
24	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5375
# text = Interestingly, PGE2 or di-butyryl (Bt2)cAMP abolished the binding of NF-kappa B (p50/p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA/A23187.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	di-butyryl	di-butyryl	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	Bt2	Bt2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
21	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
34	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	/A	/A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	23187	23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5376
# text = Our results suggest that the target of PGE2 action is a component in the signal transduction pathway leading to the activation of protein kinase C.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	component	component	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5377
# text = However, the inhibition of the T cell activation signals by PGE2 is selective.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5378
# text = PGE2 enhanced the complex formation with NF-AT, AP-1 and CLE0 sequences when the cells were activated by either anti-CD3 mAb or PMA/A23187 stimulation.
1	PGE2	PGE2	X	LS	_	_	_	_	_
2	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
5	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	when	when	ADV	WRB	PronType=Int	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	either	either	CCONJ	CC	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/A23187	/A23187	NUM	CD	NumType=Card	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5379
# text = It seems therefore that PGE2, by elevating cAMP levels, interferes with the activation pathway for NF-kappa B but not for NF-AT, AP-1 or CLE0 binding protein.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	elevating	elevat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5380
# text = Document 003001409 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001409	003001409	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n